Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2026
• Auteurs : Haotian LiXianfeng LiuYu FengPhilippe CiaisWigneron J.-P.David MakowskiXiaojun Li
• Organismes : Shaanxi Normal University Shaanxi Normal University Eastern Institute of Technology [Ningbo, China] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Contrôles des cycles biogéochimiques terrestres Interactions Sol Plante Atmosphère Mathématiques et Informatique Appliquées Interactions Sol Plante Atmosphère
• Publié dans Agricultural and Forest Meteorology le 26/10/2020

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Résumé : African woody vegetation plays a crucial role in regulating tropical land carbon flux variability and is important for global climate mitigation. However, our knowledge of its long-term trajectories remains limited. Here, we combine microwave satellite observations from VODCA Vegetation Optical Depth (VOD) and l-VOD products to analyze the long-term trends in African woody cover during 1988–2020, and employ a Random Forest model to uncover the main drivers of woody cover dynamics. The VOD-derived woody cover estimates were evaluated against both multiple satellite-based woody cover products and independent field observations (R² = 0.60–0.83), indicating robust overall agreement. Based on this analysis, we estimate a reversal in the woody cover trend around 2010 over Africa in 40% of African woodland area, with a reduction in woody cover after 2010 offsetting approximately 32% of the gains observed before 2010. This reversal was particularly pronounced in southern Africa where woody cover trend shifted from a significant increases (1.6%·decade-1 (95%CI: 1.1%, 2.2%)) before 2010 to a significant decrease after 2010 (-1.4%·decade-1 (95%CI: -4.1%, 0.3%)). Land cover change is identified as the most influential factor in driving changes in woody cover, contributing 35.1% of the total importance, followed by vapor pressure deficit (VPD, 28.3%) and precipitation (9.2%). Earth system models from CMIP6 largely fail to capture both the temporal reversal point and spatial hotspots of woody cover trend reversal observed in our satellite-based analysis, indicating limited capability in reproducing recent changes in African woody vegetation. These findings provide observational evidence that, although woody plant encroachment and CO₂ fertilization driving increases in some dryland regions, these gains have been offset by significant regional-scale declines in woody cover that emerged around 2010 across parts of Africa. This spatial divergence challenges the previous consensus of a widespread and continuous increase in woody vegetation in this part of the world.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2026
• Auteurs : Aiste LengvenyteWahid BoukouaciChing-Lien WuBruno AouizerateFrank BellivierFabrice BernaDelphine CapdevielleIsabelle ChereauClément DondéCaroline DubertetB EtainEric FakraEmmanuel HaffenDominique JanuelTheo KorchiaAntoine LefrèrePierre-Michel LlorcaDavid MisdrahiMircea PolosanRomain ReyPaul RouxLudovic SamalinFranck SchürhoffRaymund SchwanDavid SzekelyEtienne VeryMichel WalterAntoine YrondiCaroline BarauÉmilie OliéMarion LeboyerPhilippe Courtet
• Organismes : Fondation FondaMental [Créteil] CHU Montpellier = Montpellier University Hospital Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor Institut Mondor de Recherche Biomédicale Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor Institut Mondor de Recherche Biomédicale Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Fondation FondaMental [Créteil] Optimisation thérapeutique en Neuropsychopharmacologie AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Fondation FondaMental [Créteil] Neuroscience et Psychiatrie Translationnelle de Strasbourg Fédération de Médecine Translationnelle de Strasbourg Hôpitaux Universitaires de Strasbourg Fondation FondaMental [Créteil] Hôpital la Colombière [CHU Montpellier] Neuropsychiatrie : recherche épidémiologique et clinique Fondation FondaMental [Créteil] CHU Clermont-Ferrand Institut Pascal Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Universitaire de Grenoble-Alpes [CHU Grenoble] Fondation FondaMental [Créteil] AP-HP - Hôpital Louis Mourier Institut de psychiatrie et neurosciences de Paris Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive Centre d'Investigation Clinique de Besançon Centre Hospitalier Régional Universitaire de Besançon Fondation FondaMental [Créteil] Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Université Sorbonne Paris Nord Fondation FondaMental [Créteil] Hôpital Sainte-Marguerite [CHU - APHM] Fondation FondaMental [Créteil] Assistance Publique - Hôpitaux de Marseille Institut de Neurosciences de la Timone Fondation FondaMental [Créteil] CHU Clermont-Ferrand Institut Pascal Fondation FondaMental [Créteil] Institut de Neurosciences cognitives et intégratives d'Aquitaine Centre hospitalier Charles Perrens [Bordeaux] Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Universitaire de Grenoble-Alpes [CHU Grenoble] Fondation FondaMental [Créteil] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier le Vinatier [Bron] Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Centre de recherche en épidémiologie et santé des populations Fondation FondaMental [Créteil] CHU Clermont-Ferrand Institut Pascal Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor Institut Mondor de Recherche Biomédicale Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Imagerie Adaptative Diagnostique et Interventionnelle Fondation FondaMental [Créteil] Centre Hospitalier Princesse Grace Fondation FondaMental [Créteil] Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs Centre Hospitalier Universitaire de Toulouse Fondation FondaMental [Créteil] Hôpital de Bohars [CHRU Brest] Fondation FondaMental [Créteil] Centre Hospitalier Universitaire de Toulouse Toulouse NeuroImaging Center AP-HP - Hôpital Henri-Mondor Université Paris-Est Créteil Val-de-Marne - Paris 12 Fondation FondaMental [Créteil] CHU Montpellier = Montpellier University Hospital Institut de Génomique Fonctionnelle IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil]
• Publié dans Brain, Behavior, and Immunity le 29/10/2020

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Résumé : Background: Bipolar disorder (BD) and schizophrenia-spectrum disorders (SZ) are associated with high rates of suicidal ideation (SI) and suicide attempts (SA). Peripheral immune-vascular abnormalities may contribute to suicidal vulnerability in these disorders, but their specificity, temporal meaning, and diagnostic patterning remain unclear. Methods: We quantified 28 peripheral immune-vascular variables (cytokines/chemokines, vascular-injury markers, blood counts, lipids) in 980 French FACE (FondaMental Advanced Centres of Expertise) outpatients with BD (n = 529) or SZ (n = 451). Elastic-net logistic regression and partial least-squares regression for binary outcomes examined associations with SA, baseline SI, and SI over 12 months in pooled and diagnosis-stratified samples. Models adjusted for age, sex, and body mass index, with sensitivity analyses for depression severity, medication classes, smoking, phenotype overlap, attrition, and missing data. Results: In pooled analyses, SA was associated with higher vascular endothelial growth factor; stratified analyses suggested this signal was mainly driven by BD (OR = 1.33, 95% CI 1.08-1.64). In SZ, SA showed weaker platelet/SAA-related associations. Baseline SI showed more consistent multivariate signals than individual analytes; in BD, higher IL-7 and SAA remained associated with SI after adjustment, whereas SZ findings were more medication-sensitive. SI over 12 months showed the least stable associations; in BD, lower IL-7 was associated with follow-up SI (OR = 0.72, 95% CI 0.54-0.96). Internal validation indicated stronger performance for baseline SI than for SA or follow-up SI. Conclusions: We found modest, phenotype-dependent and partly diagnosis-specific peripheral immune-vascular correlates of SI and SA in BD and SZ. Replication and direct biological validation are needed.

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Fichiers liés : NutriNeuro_BrainBehavImmun_2026_Lengvenyte.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2026
• Auteurs : Guillaume ChagnaudPablo FernándezCheikh Modou Noreyni FallThomas FiolleauPaul-Arthur MonerieSidiki SanogoGabrielle SoriniBenjamin SultanMamadou ThiamMassara DiakhatéAlessandra GianniniChristophe LavaysseThéo VischelJean-Pierre ChaboureauBastien DieppoisJuliette MignotMoussa DiakhatéPhilippe Peyrillé
• Organismes : CEH Wallingford Laboratoire de Météorologie Dynamique (UMR 8539) Océan et variabilité du climat Laboratoire de Physique de l'Atmosphère et de l'Océan Siméon Fongang Laboratoire d'études en Géophysique et océanographie spatiales National Centre for Atmospheric Science [Reading] Institut Pierre-Simon-Laplace UMR 228 Espace-Dev, Espace pour le développement Transitions Energétiques et Environnementales Pôle de recherche interdisciplinaire en sciences du management École normale supérieure - Paris Institut des Géosciences de l’Environnement Institut des Géosciences de l’Environnement Laboratoire d'aérologie Coventry University Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques Laboratoire de Physique de l'Atmosphère et de l'Océan Siméon Fongang Université Amadou Mahtar Mbow Groupe de Météorologie à Moyenne Échelle
• Publié dans La Météorologie le 02/11/2020

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Fichiers liés : meteo_2026_134_54.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2026
• Auteurs : Rodrigue GarciaFawzi KerkouriChristelle MarquiéMina Ait SaidFrédéric AnselmeWarda AoudjeghoutNicolas BadencoMarc BadozSergio BarraOlivier BarthezHugues BlangyPierre BordacharLaure Champ-RigotStéphane CombesPascal DefayeJean Claude DeharoEstelle GandjbakhchEdouard GitenayHervé GorkaIsabelle HeurtebiseJérôme HourdainLaurence JeselLila KhrisAlain LebonChristophe LeclercqSophie Le PageAlexis MechulanPierre MondolyJean-Luc PasquiéDavid PerrotBertrand PierreOlivier PiotAnne QuentinEric RenduOlivier VillejoubertVictor WaldmannOrianne WeizmanVincent ProbstSerge BovedaEloi MarijonAlexandre Doucy Alexandre DoucyHassan BarakeAziz KneizehDidier ScarlattiFabien SquaraSok-Sithikun BunPhilippe DurandLara DabiriPhilippe RicardLaurent LiprandiGarret GauthierFolco FrattiniYann Dagher. HayeckAlaa Al AmouraBruno MaillierDenis GatyLilian MartyMohammed Benkaci AliJean Claude DeharoJérome HourdainBaptiste MailleMickael PeyrolJérémie BarraudFlorian BaptisteJerome TaiebJerome BouetGilles MacalusoAlexis MechulanSébastien PrevotAhmed BouharaouaEdouard GitenayClement BarsJulien SeitzLaure Champ RigotPierre OllitraultPaul-Ursmar MilliezArnaud PellissierAlain LebonSophie GomesPamela DamianoAntoine MilhemCecile DuplantierCyril GoujeauIsabelle HeurtebiseLila KhrisCharles GuenanciaGéraldine BertauxGabriel LaurentAudrey SagnardMarie FichotSylvain BodiAnne QuentinJean LitalienMathieu CourtheixPhilippe JarnierMarc BadozBaptiste FavouletGuillaume SerzianHugues ZimmermannAurélien MirallesMarie Pierre ChatelEric RamiaramananaHervé GorkaMaria MoldovanChristophe LaureJacques MansouratiFawzi KerkouriVincent MansouratiHugo HagerPierre WinumJulien RouxPénélope PujadasPierre MondolyPhilippe MauryGuillaume DomainSerge BovedaNicolas CombesStéphane CombesChristèle CardinJean-Paul AlbenqueRomain CassagneauPierre BordacharSylvain PlouxFrédéric SacherNicolas DervalMarc StrikOlivier CesariRim El BouazzaouiAdlane ZemmouraThien-Tri CungFrederic CransacNicolas ClementyJean-Luc PasquiéMathieu GarnierNathalie BeharVincent GalandRaphaël P MartinsDominique PavinFrédéric VictorBertrand PierreLaurent FauchierArnaud BissonCyril ZakineChristophe LooseAkli OtmaniPascal DefayePeggy JaconAdrien CarabelliSandrine VenierLuc PetitXavier DreyfusCorina MoldovanAntoine da CostaCécile Romeyer-BouchardJean-Baptiste GuichardJerome TheveninVincent ProbstJean-Baptiste GourraudMarine ArnaudDamien MinoisDaniel GrasCédric GiraudeauRadu MoiseiRené Gabriel HuguetJulien RischardSoraya AnysBenjamin MonteilSophie Le PageMouna Ben KilaniFrederic TreguerMichel MerhebJean Pierre ChabertFrancois LesaffreMadeline EspinosaNicolas LuconiThibault VilleminRaphael SandrasKarim Bel HadjJerome SchwartzArnaud OlivierDaniel BeurrierPierre-Yves ZinziusNicolas SadoulHugues BlangyLuc FreyszChristian de ChillouStéphane EvainEric RenduPierre KhattarAude ZanuttoMarc MielczarekJulien BertrandMathieu BeckerPierre HouriezYves GuyomardAymeric MenetOlivier BrimontKarine BauleyStephane DennetiereChristelle MarquiéCharlotte PotelleDidier KlugRomain SellierLaura ForelleFrédérique Mizon-GérardArthur VaksmannFrederic ElmkiesThierry ZerahEric VerbruggeAurélie GuiotMarc PoueymidanetteEmilie MarcantClaire VanessonThibault HusRomain EschalierFrederic JeanGrégoire MassoulliéYannick SaludasFrançois PhilippotAntoine RouxMaxime de GuillebonHugues BaderPrune GaillardPhilippe CoudercAurelien HebrardNicolas KlotzJulien LaborderieMichel LerecouvreuxChristian DemaslesSorin PriponMichel VoglimacciDominique CelsePhilippe LagrangeZiad Khoueiry Ziad KhoueiryPierre SultanGeorges NadjiMathieu SteinbachSebastien BufflerinMichel ChauvinAlexandre SchatzLaurence JeselSophie PynnSandrine BellmontJacques LevyRonan Le BouarSerban SchiauLucien DieneFrancis BessiereArnaud DulacPhilippe ChevalierKevin GardeyCyril DurandAlexis Durand DubiefHugo BrahicHervé PotyBenjamin GalJulien PineauSamuel ChauveauOlivier GarrierMichael AttaliSamir FarehMathieu MontoyPierre LantelmePaul CharlesCédric NguyenMathieu AmelotPhilippe PoretJean Christophe AmiraultRaoul BacquelinPierre FreyDidier IrlesAntoine DompnierChrystelle AkretEdouard SiméonOlivier VillejoubertNicolas MignotPierre JorrotYamina MouhoubLionel OvartJacky OllitraultDenis AmetDavid PerrotEmilie VarletPierre BaudinaudThomas LavergneXavier JouvenSéverine PhilibertPauline PinonTej ChalbiaVictor WaldmannEloi MarijonNicolas BadencoEstelle GandjbakhchGuillaume DuthoitMikael LaredoXavier WaintraubAnne MessaliAntoine LeenhardtVincent AlgalarrondoFabrice ExtramianaVictor WaldmannDamien BonnetBenedicte GodinFrederic AnselmeArnaud SavouréCorentin ChaumontNathanael AuquierPopescu ElenaPierre Le FrancFanny BouchinetCyrus MoiniAudrey LefoulonMohamed BelhamecheSana SiouaAbdeslam BouzemanCathy BertrandFranck HalimiThomas ChastreKhadidja BelkirRaphael GdaliaDenis AmetJean Sylvain HermidaAlexis HermidaAkli OtmaniMaciej KubalaSarah TraulleDenis RaguinMarie Blaye-FelicePhilippe RumeauPascal ChavernacMarion PoucheNouredine El HajjajiEmilie BastardIsabelle LecardonnelEssia Lakhal-Ben LarbiGilles CellarierRaphaël DemoulinOlivier BarthezJean Paul FaugierSaida CheggourFrançois Xavier HagerFrédéric OrtunoOlivier BillonRodrigue GarciaBruno DegandFrançois Le GalBenoit Guy MoyatFrançois JourdaStéphane MourotRenaud FouchéJerome HorvilleurLaurent FiorinaJerome LacotteFiorella SalernoSalem YounsiMina Ait SaidVladimir ManentiMohanad MahfoudMonteau JacquesVladimir ManentiDominique BleincChristine AlonsoArnaud LazarusGhassan MoubarakOlivier ThomasArdalan SharifzadehganAlexandre ZhaoChristophe JuinVincent KanczugaHenri BroustetNicolas CombesAlice MaltretAbdelhamid BenounaneXavier CopieOlivier PiotWalid AmaraVanessa AbdouFabien MonselNicolas LelloucheNathalie ElbazSegolene Rouffiac-NoelGuillaume GalidieLaurentiu Dorian NituGabriel LatcuBogdan EnacheNicolas HuguesIsabelle LagrenadeFabrice DemoniereInamo JocelynAndréas MüssigbrodtOlivier GeoffroyGael ClericiFrançois WiartBruno UlmerGuillaume KabaluOlivier AxlerEloi Marijon
• Organismes : Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image CHU Montpellier = Montpellier University Hospital Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Paris-Centre de Recherche Cardiovasculaire Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
• Publié dans JACC: Clinical Electrophysiology le 31/10/2020

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Résumé : Background: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is an established therapy for sudden cardiac death prevention, but sex-specific outcomes remain incompletely characterized. Objectives: This study evaluated sex-related differences in baseline characteristics, appropriate shocks, complications, reinterventions, and mortality among S-ICD recipients. Methods: The nationwide HONEST (S-ICD French Cohort Study) cohort enrolled all patients who received an S-ICD in France between 2012 and 2019. Clinical endpoints were centrally adjudicated. Sex-specific associations with outcomes were assessed by using propensity score-based inverse probability weighting. Results: Among 4,924 S-ICD recipients, 1,148 were women (23.3%). Compared with men, women were younger (47.3 ± 15.6 years vs 50.6 ± 14.7 years; P < 0.001), less frequently received an implant for primary prevention (57.6% vs 65.1%; P < 0.001), less often had coronary artery disease (38.9% vs 56.5%; P < 0.001), and more often had electrical heart disease (26.3% vs 20.4%; P < 0.001). After adjustment, women had a lower 5-year risk of appropriate shocks (HR: 0.85; 95% CI: 0.74-0.98; P = 0.023) and similar overall complication and reintervention rates but a distinct complication profile, with higher risks of chronic pain (HR: 2.63; 95% CI: 1.61-4.29; P < 0.001) and lead dislodgment (HR: 1.79; 95% CI: 1.09-2.95; P = 0.022) and a lower risk of inappropriate shocks (HR: 0.64; 95% CI: 0.50-0.82; P < 0.001). All-cause mortality was lower in women, whereas S-ICD-unresponsive sudden death and device-related mortality were similar. Conclusions: Women receiving an S-ICD experienced fewer appropriate shocks, with similar overall complication and reintervention rates, but a distinct complication profile. These findings support sex-informed S-ICD selection and follow-up. (S-ICD French Cohort Study [HONEST]; NCT05302115).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2026
• Auteurs : Pierre TankeréClaudio RabecAmeline VagnerPierre MouillotDeborah SchenesseStephane MourauxPhilippe BonniaudMarjolaine Georges
• Organismes : Hospices Civils de Lyon Université Grenoble Alpes Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Service of Neurology [CHUV, Lausanne, Switzerland] Université de Lausanne = University of Lausanne Centre de référence maladies rares des maladies pulmonaires rares de l’adulte [CHU Dijon] Centre de référence maladies rares des maladies pulmonaires rares de l’adulte [CHU Dijon] Centre de référence maladies rares des maladies pulmonaires rares de l’adulte [CHU Dijon] Service of Neurology [CHUV, Lausanne, Switzerland] Université de Lausanne = University of Lausanne Centre de référence maladies rares des maladies pulmonaires rares de l’adulte [CHU Dijon] Université Bourgogne Europe Centre de référence maladies rares des maladies pulmonaires rares de l’adulte [CHU Dijon] Centre des Sciences du Goût et de l'Alimentation [Dijon]
• Publié dans Respiratory Medicine le 28/10/2020

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Résumé : BACKGROUND: The rising prevalence of hypercapnic chronic respiratory failure (HCRF) raises questions about how to initiate and adjust noninvasive ventilation (NIV), which is the first-line treatment. The current literature regarding the prevalence of patient ventilator asynchronies (PVA) and their impact on patient gas exchange is limited. METHODS: This single center observational cohort study describes the monitoring of consecutive patients treated with a long-term indication for NIV. Polygraphy was used to assess leaks, upper airway obstruction (UAO), and PVA rate (% of recording time and events per hour of recording). Linear regressions were performed to assess correlations with PaCO(2), TcPCO(2) and SpO(2). RESULTS: 123 patients with varying HCRF etiologies were included, median age 69.0 (59.0,78.0) years, with a slight female predominance. Median morning PaCO(2) was 48.5 (43.1,54.8) mmHg. The main rate asynchrony scored was ineffective effort. In treated patients, morning PaCO(2) was significantly positively correlated with PVA (both as a percentage and an index) and UAO index. Mean TcPCO(2) and mean SpO(2) were significantly correlated (respectively positively and negatively) with PVA as a percentage and an index. Other significant factors correlated with PaCO(2) included disease categories, while UAO was also associated with hypoxemia. Leaks did not reach significance. CONCLUSION: Our findings indicate that asynchronies are associated with impaired gas exchange in patients receiving long-term NIV. Therefore, after adequately adjusting NIV pressure support and interface, close monitoring is required for patients with residual hypoventilation to detect and correct the underlying mechanisms.

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Fichiers liés : Tankere_2026_vol260_108922_resp_med.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2026
• Auteurs : Bao Tran VuongChloé DelépineJacqueline Ratter-RieckElisabetta RinaldiJean-Baptiste JullaEmma CussenotMarc DiedisheimVioletta RaverdyElise LiuJustus FischerMatthias HepprichFawaz AlzaidCamille BleriotEtienne BechtClémence CornuotJoe de KeizerMacine-Bachir AbdelouahabMagali ChiralRebecca PfeilPolina LipaevaDaniel DoerrOana ZahariaThéo JolivetJulie AlbergeCharline PotierKennan KhiderFrédérik OgerJean-Pierre RivelineTiphaine Vidal-TrecanFlorence TubachCandice EstellatJudith AbécassisAymeric SilvinSamy HadjadjGaël VaroquauxRobert WagnerPhillippe FroguelAmelie BonnefondPierre-Jean SaulnierFrançois PattouFlorent GinhouxMichael RodenMaddalena TrombettaLouis PotierChristian HerderJean-François GautierMarc DonathRiccardo BonadonnaNicolas Venteclef
• Organismes : Institut Necker Enfants-Malades Immunité et métabolisme dans le diabète = IMmunity and MEtabolism in DIABetes [CRC] Hôpital Simone Veil [Eaubonne] Institut Necker Enfants-Malades Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] Università degli studi di Verona = University of Verona Azienda Ospedaliera Universitaria Integrata of Verona = Verona University Hospital Trust Service de diabétologie et d'endocrinologie [CHU Lariboisière] Immunité et métabolisme dans le diabète = IMmunity and MEtabolism in DIABetes [CRC] Institut Necker Enfants-Malades CentraleSupélec Institut Necker Enfants-Malades Méthodes computationnelles et mathématiques pour comprendre la société et la santé à partir de données Institut Necker Enfants-Malades Nouvelle Clinique de Tours Saint Gatien-Alliance [Tours] Recherche translationnelle sur le diabète = Translational Research laboratory for Diabetes Service de chirurgie générale et endocrinienne [CHU Lille] Pharmacoépidémiologie et évaluation des soins Institut Necker Enfants-Malades Centre National de la Recherche Scientifique Institut Gustave Roussy Centre de recherche sur l'Inflammation Institut Gustave Roussy CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Institut Necker Enfants-Malades AG Genominformatik Service de diabétologie et d'endocrinologie [CHU Lariboisière] Institut Necker Enfants-Malades UFR Médecine [Santé] - Université Paris Cité Assistance publique - Hôpitaux de Paris Institut Pierre Louis d'Epidémiologie et de Santé Publique Méthodes computationnelles et mathématiques pour comprendre la société et la santé à partir de données Institut Polytechnique de Paris CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) DECLAN : Functional DECLine and multimodal ANalysis [Axe de recherche du CIC de Poitiers – CIC 1042] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 0802)
• Publié dans Cell Metabolism le 29/10/2020

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Résumé : Type 2 diabetes (T2D) is a heterogeneous disease, yet current classifications do not capture its clinico-biological complexity or support precision-based care. We developed an endotyping strategy based on routine blood immune cell counts across more than 1,500 individuals with newly diagnosed T2D from three European cohorts. Unsupervised clustering identified four reproducible immune endotypes: severe inflammatory diabetes (SIND), mild inflammatory diabetes (MIND), lymphocyte-rich diabetes (LYRD), and lymphocyte-deficient diabetes (LYDD). Endotypes were stable, robust to de novo clustering, and independent of age, sex, BMI, and HbA1c. SIND and LYDD were associated with increased cardiovascular, renal, and mortality risk across cohorts. Immune endotyping improved cardiovascular risk prediction beyond SCORE2-Diabetes. Multi-omic profiling revealed immunopathological states, with high-risk endotypes characterized by monocyte-driven inflammation and dysregulated lymphocyte programs. The inflammatory profile of SIND was attenuated by IL-1β antagonism and bariatric surgery. These findings establish immune endotyping as a scalable framework for immunometabolic risk stratification in T2D.

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• Type de publi. : Article dans une revue
• Date de publi. : 30/07/2026
• Auteurs : Timothy DalyDavid C. VaidisJulien BrunierMarion Prud'HommeHélène AckerLucille CazenavePhilippe BihouixRomain Manet
• Organismes : Facultad Latinoamericana de Ciencias Sociales (FLACSO)- Argentina Sciences, Normes, Démocratie Cognition, langues, langage, ergonomie École des Hautes Études en Santé Publique Association The Shifters Collectif d’EcoResponsabilité En Santé Université de Rennes Association The Shifters Association The Shifters Centre for Doctoral Training in AI for Healthcare AREP Group Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
• Publié dans Advances in Clinical and Experimental Medicine le 04/01/2022

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Résumé : Industrial societies have experienced exponential growth in both technological innovation and life expectancy. “High-tech medicine” – the dominant paradigm – assumes that technological innovation is the primary pathway to improving health. However, trade-offs among patient care, environmental impacts, public health, costs, and accessibility are rarely made explicit. In the context of multiple global crises, including climate change, biodiversity loss, rising inequalities, and geopolitical instability, we argue that perpetual and unrestricted technological development in healthcare is unsustainable. As an alternative framework, we explore the concept of “low-tech medicine” and seek to clarify its definition and scope. A standard scoping review methodology proved unsuitable: a literature search using MEDLINE and Web of Science restricted to “low-tech medicine” and related terms yielded very few relevant references, whereas broadening the search retrieved thousands of heterogeneous results across diverse fields. We therefore adopted a hybrid approach combining selected peer-reviewed literature with additional sources (grey literature, web-based resources, and textbooks), structured through an analytical framework derived from the multidisciplinary reflections of the LowTechMed group. Rather than a strict definition, “low-tech medicine” should be understood as a guiding mindset for medical research and practice, based on 3 core criteria: 1) relevance, referring to usefulness within a given context; 2) sustainability, encompassing financial and environmental considerations; and 3) accessibility, including local resilience and the reduction of health inequalities. “High-tech medicine” presents an increasingly unsustainable benefit–harm trade-off. A “low-tech medicine” mindset may offer a pathway toward more effective, equitable, and resilient healthcare systems.

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Fichiers liés : 224445.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 23/07/2026
• Auteurs : Jean-Luc DupoueyLaurent BergèsNathalie LeroyRomain LafiteFrédéric ArchauxVincent AugéRaphaël BecMaxime BellifaJulien BourguignonJérôme BuridantBéatrice BurlinSimon CaubetAlbane ChaléatSandrine ChauchardThomas CordonnierGuillaume DecocqMatthieu DelcampJulien FleurySylvain GaudinAlain GervaiseGrégoire GautierJulien-Pierre GuillouxArnoul HamelWilfried HeintzPhilippe JanssenSophie LabonnePerrine LairThierry LallemantGuy LandmannLaurent LarrieuHilaire MartinClaude MichelSylvain MollierChristophe PanaïotisBenoît RenauxXavier RochelAline SalvaudonMarie ThomasThierry TouzetDaniel Vallauri
• Organismes : SILVA Laboratoire des EcoSystèmes et des Sociétés en Montagne SILVA Environnements, Dynamiques et Territoires de Montagne Ecosystèmes forestiers Parc national de la Vanoise CRPF occitanie Institut National de l'Information Géographique et Forestière [IGN] Institut National de l'Information Géographique et Forestière [IGN] Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 UPJV Institut National de l'Information Géographique et Forestière [IGN] Conservatoire d'Espaces Naturels de Nouvelle-Aquitaine Fédération Départementale des Chasseurs de Savoie IPAMAC SILVA Recherche, développement et innovation Ecologie et Dynamique des Systèmes Anthropisés - UMR CNRS 7058 UPJV Centre de Coopération Internationale en Recherche Agronomique pour le Développement Ecosystèmes forestiers CRPF Champagne ardenne Institut National de l'Information Géographique et Forestière [IGN] Parc national des Cévennes Parc national des Ecrins Parc Naturel Régional du Luberon Dynamiques et écologie des paysages agriforestiers Laboratoire des EcoSystèmes et des Sociétés en Montagne Université Grenoble Alpes Parc naturel régional du Massif des Bauges Institut National de l'Information Géographique et Forestière [IGN] Groupement d'Interêt Public Ecosystèmes Forestiers GIP ECOFOR Dynamiques et écologie des paysages agriforestiers Centre National de la Propriété Forestière Ecosystèmes forestiers Parc naturel régional des Ballons des Vosges Institut National de l'Information Géographique et Forestière [IGN] Office de l'environnement de la Corse Conservatoire Botanique National du Massif Central Université de Lorraine Parc national des Cévennes Office français de la biodiversité Institut National de l'Information Géographique et Forestière [IGN] World Wide Fund for Nature
• Publié dans BioRxiv le 18/10/2021

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Résumé : Integrating environmental history is essential for understanding present-day ecosystem dynamics and guiding modern conservation strategies, particularly under the EU Biodiversity Strategy for 2030. This data paper presents the nationwide digitisation and vectorisation of the French General Ordnance survey map (1818–1866), capturing the country’s forest cover at its historical minimum (a pivotal moment known as the “forest transition”). The original manuscript sheets surveyed at a 1:40,000 scale (976 sheets) were scanned, georeferenced and vectorised. They offer higher thematic accuracy than the older Cassini map and are far more feasible for nationwide vectorisation than the highly detailed Napoleonic cadastre. The area-weighted mean survey date is 1843, and the dataset covers 99.6% of modern mainland France. To correct for paper deformation, historical surveying errors and coordinate system transformations, a rigorous workflow was established. This shifted from a global 6-parameter affine transformation (root mean square error of 60 m) to a local elastic transformation based on thousands of control points, for 21% of the territory, which reduced the positioning error to 34 m. We assessed data quality by comparing the General Ordnance Survey maps with the Napoleonic cadastre—the standard reference for 19 th -century land-use data—across more than 600 municipalities. The correlation between the two sources regarding forest cover percentages was exceptionally high (r>0.9). Because forests formed large, compact blocks of significant strategic interest to military engineers, they were mapped with high precision. Localised inaccuracies were primarily found in remote areas, most notably in the mountains. The resulting historical vector layer was intersected with contemporary forest data (BD Forêt® v2, 2005–2019). Historical polygons smaller than 0.5 ha were filtered out to comply with modern FAO forest definitions. This spatial overlay generated a new dataset detailing four distinct land-use trajectories: . ancient forests (44.8% of present day forest): land classified as forest in both the 19 th century and the present day (indicating maximum temporal continuity). . recent forests (55.2% of present day forest): land that was non-forested in the 19 th century but has since undergone reforestation. . deforested areas (18.9% of 19 th -century forest): land recorded as forest in the 19 th century but subsequently converted to other land uses. . stable non-forest areas: land that has remained unforested across both periods. Our results suggest that the forest area of mainland France at its historical minimum should be revised upward to 9.9 million ha. A preliminary analysis further indicates that current spatial variation in forest cover is explained more by land-use dynamics occurring since the forest transition than by the initial extent of forest cover. These two open-access national datasets (the 19 th -century forest layer and the land-use transition map) open the door to a better understanding of present-day forests : e.g. their biodiversity, soil quality, tree growth and belowground water quality. Furthermore, they provide decision-support tools for conservation planning. Key message In this data paper, we provide a map of 19 th -century forests in France based on the digitisation of the military topographic map (1818-1866). By overlaying this historical source with the present-day forest map, we built a second map which allows the identification of ancient forests, recent forests, and deforestation. These maps offer avenues for historical ecology and the design of conservation strategies.

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Fichiers liés : 2026.07.22.Larrieu.pdf

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 23/07/2026
• Auteurs : Arzunik GevorgyanAram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamLisa BenatoThomas BergauerMarko DragicevicStefan GundackerAli Kaan GuvenPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark Nicholas MatthewmanJochen SchieckRobert SchoefbeckMaryam ShooshtariMangesh SonawaneNiels van den BosscheWolfgang WaltenbergerClaudia WulzTahys JanssenDaniel Ocampo HenaoThomas van LaerPierre van MechelenDonya AhmadiJas BierkensNordin BreugelmansSoumya DansanaAlexandre de MoorMartin DelcourtStef DuponcheelChirayu GuptaFelix Johannes HeyenYanwen HongKai KangPavlo KashkoSteven LowetteInna MakarenkoSaranya NandakumarStefaan TavernierMichael TytgatGerrit van OnsemSenne van PutteTiepolo WybouwAya BeshrBugra BilinFranco Caviglia RomanBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerEliott DucarmeHugues EvardLaurent FavartIlia KalaitzidouAli KhalilzadehAndrea MalaraAndris PotrebkoMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerChaochen YuanFengwangdong ZhangAmber Kristin CauwelsMaarten de CoenDidar DoburCristina GiordanoGul GokbulutKaram KasparDavid KavtaradzeDavid Marcus E MarckxAnkita MehtaKirill SkovpenAdina Maria TomaruJan van der LindenJules VandenbroeckHenriette Aarup PetersenAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome Paul E de Favereau de JeneretChristophe DelaereFrancisco CasalinhoAndrea GiammancoOguz GuzelMajid HussainZak LawrenceVincent LemaitreJindrich LidrychPaul MalekSemra TurkcaparGilvan Augusto AlvesMapse Barroso Ferreira FilhoEduardo Alves CoelhoMarcos Venicio Goncalves SalesCarsten HenselDiego FigueiredoThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson Jose Tonelli ManganoteAntonio Vilela PereiraWalter AldaHelena Brandao MalbouissonWagner de Paula CarvalhoJose Augusto ChinellatoGilson Correia SilvaMatheus Costa ReisEliza MeloDalmo da Silva DaltoGustavo Gil da SilveiraDilson de Jesus DamiaoSandro FonsecaRaphael Gomes de SouzaSilas Santos de JesusTulio Laux KuhnKatherine Maslova Gioseffi DefanteKevin Mota AmariloLuiz MundimHelio NogimaJoao PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe SilvaDiego Torres MachadoCesar BernardesLuigi CalligarisJulia Carvalho LeiteFlorian DamasEduardo de Moraes GregoresBruno LopesIsabela Maietto SilverioPedro Galli MercadanteSergio Ferraz NovaesSandra PadulaMatheus Pereira CoelhoValerie ScheurerThiago Tomei FernandezAleksandar AleksandrovGueorgui AntchevPetar Mladenov DanevRoumyana Mileva HadjiiskaPlamen Stoianov IaydjievMariana ShopovaGueorgui SoultanovAnton DimitrovLeandar LitovBorislav PavlovPeicho PetkovAnton PetrovDuccio AbbaneoChiara AmendolaRocco ArdinoEtiennette Auffray HillemannsJoachim BaechlerDavid BarneyJosh BendavidIoannis BestintzanosMichele BiancoAndrea BocciLisa BorgonoviCristina BottaAlberto BragagnoloChristopher Edward BrownCecile CaillolGianluca CerminaraPatrick Louis S ConnorKyle CormierDavid d'Enterria AdanAnne 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QinClaudio QuarantaXiaohu SunDayong WangJin WangTianyi YangMingtao ZhangMingxuan ZhangYuzhe ZhaoChen ZhouXueli HuaShuai YangZhengyun YouNan LuGerry BauerLiangliang ChenZhipeng CuiBolin LiHui WangKai YiJingqing ZhangFeng ZhuChenyan LiYuji LiZirui WangYilin ZhouZhen LinChenfeng LuMeng XiaoCarlos Avila BernalAndres Leonardo Cabrera MoraCarlos Andres Florez BustosJose Antonio Reyes VegaCesar Rendon HinestrozaManuel Alejandro Rodriguez GiraldoAnderson Alexis Ruales BarbosaJose RuizNikola GodinovicDamir LelasIvica PuljakAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisSotiroulla KonstantinouChristos LeonidouLeonidas PaizanosFotios PtochosPanos RazisHalil SakaAnton StepennovMichael FingerAntonin KvetonEliana Maribel AcurioEdgar Fernando Carrera JarrinHassan AbdallaYasser AssranBasma ElmahdyAhmed AbdallahMohammed Mahmoud MohammedHemida MohammedMuhammad MuhammadKhawla JaffelMario 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ChatterjeeLucia Ximena Coll SaraviaGuenter EckerlinDoris EcksteinElisabetta GalloAchim GeiserMoritz GuthoffAndreas HinzmannUlrich HusemannMatthias KasemannClaus Heinz KleinwortRoman KoglerMatthias KommDirk KruckerFinn Jonathan LabeWolfgang LangeDaina Leyva PerniaJia-Hao LiKuan-Yu LinEkaterina LipkaWolfgang LohmannJacopo MalvasoRainer MankelIsabell Melzer-PellmannMikel Mendizabal MorentinAndreas MeyerGabriele MilellaKeila Moral FigueroaAndreas MussgillerLakshmi Priya NairJeremi NiedzielaAndreas Matthias NurnbergJiwon ParkEvan Altair RankenAliaksei RaspiarezaDaniil RastorguevLovisa RygaardMoritz SchamSimon SchnakeChristian SchwanenbergerDennis SchwarzPaul Jean SchutzeDaria SelivanovaKonstantin SharkoMykyta ShchedrolosievAnurag SritharanDominic William StaffordMatin TorkianSoumyaa VashishthaAna Ventura BarrosoRoberval WalshDi WangQun WangKatarzyna WichmannLucas WiensChristoph WissingYewon YangStepan ZakharovAndre ZimermmaneAna AndradeMassimiliano AntonelloSven BollwegMatteo BonanomiLukas 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Résumé : A search for nonresonant triple Higgs boson (HHH) production in the final state with six bottom quarks is performed using proton-proton collisions at $\sqrt{s}$ = 13 TeV corresponding to an integrated luminosity of 138 fb$^{-1}$ recorded by the CMS experiment. No significant excess of events over the background prediction is seen. Observed (expected) 95% confidence level upper limits on the signal cross section are set at 44 (43) fb, corresponding to 588 (572) times the standard model expectation. The observed (expected) constraint on the trilinear coupling modifier $κ_3$ is $-$7.4 $\lt$ $κ_3$ $\lt$ 12.4 ($-$6.4 $\lt$ κ_3 $\lt$ 11.2), assuming the quartic coupling modifier $κ_4$ = 1. The corresponding constraint on $κ_4$ is $-$177 $\lt$ $κ_4$ $\lt$ 185 ($-$180 $\lt$ $κ_4$ $\lt$ 190), assuming $κ_3$ = 1. This analysis provides the most stringent constraint to date on nonresonant HHH production and excludes, for the first time, part of the $(κ_3,κ_4)$ space allowed by the perturbative unitarity bound.

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