Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/01/2006
• Auteurs : Jean-Philippe BoussemartJean-Pierre ButaultNathalie DelameE. MatvejevJean-Marc Rousselle
• Organismes : Groupe de Recherches Modélisation Appliquée à la Recherche en Sciences Sociales Economie Publique Economie Publique Laboratoire d'Economie Forestière

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Résumé : Il existe un vieux débat en économie agricole sur l'existence d'économie d'échelle et la taille optimale des exploitations. Ce débat a été récemment renouvelé, dans la littérature, pour les pays en transition où coexistent de très grandes et petites exploitations. Cette étude s'appuie sur les données du RICA estonien d'où a été extrait un échantillon en panel de 170 exploitations laitières entre 2000 et 2003. Les performances des firmes sont appréciées par quatre approches : l'observation du coût de production du lait en fonction de la taille des exploitations, l'estimation de fonction de coût, l'estimation de fonction de Cobb-Douglas et l'emploi de la méthode DEA. Les résultats sur les économies d'échelles varient selon les méthodes employées. L'hypothèse de rendement d'échelle constant n'est pas rejetée au vue de certains résultats. D'autres résultats conduisent à considérer que les meilleures performances sont atteintes par les exploitations de taille moyenne. L'avenir des exploitations familiales et des sociétés dépend, en Estonie, de nombreux facteurs. Avec l'application de la PAC, le découplage des aides peut notamment encourager le développement de l'agriculture familial au détriment des sociétés.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Anne FaucheuxAnne Chantal Gouget-LaemmelCatherine Henry de VilleneuveRabah BoukherroubFrancois OzanamPhilippe AllongueJean-Noël Chazalviel
• Organismes : Laboratoire de physique de la matière condensée Laboratoire de physique de la matière condensée Institut de Recherche Interdisciplinaire [Villeneuve d'Ascq] Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 Laboratoire de physique de la matière condensée Université Pierre et Marie Curie - Paris 6 Physique de la Matière Condensée
• Publié dans Langmuir le 27/10/2020

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Résumé : This work demonstrates that well-defined mixed carboxyl-terminated/methyl-terminated alkyl monolayers can be prepared in one step on H-terminated Si(111) via direct photochemical hydrosilylation of undecylenic acid and 1-decene mixtures. As evidenced by AFM imaging and IR spectroscopy, a final rinse in hot acetic acid leaves the functionalized surface atomically smooth and perfectly free of physisorbed contaminants while unwanted material remains atop the monolayer with most other common solvents. The compositional surface chemistry was determined from a truly quantitative IR (ATR geometry) study in the range of 900−4000 cm-1. Results prove that neither surface oxidation nor grafting through the carboxyl end groups occurs. Monolayers are fairly dense for such bulky end groups, with a total molecular surface density of ∼2.7 1014 cm-2 corresponding to a surface coverage of 0.35 (maximum theoretical value ∼0.5). Careful analysis of the CH- and COOH-related IR bands reveals that the composition of the grafted layers is richer in acid chains than the starting grafting mixture. A simple model is presented that shows that the grafting kinetics is about twice as fast for undecylenic acid as for 1-decene. Complementary electrochemical impedance measurements indicate the excellent electronic properties of the interface with a very low density of gap states. They also show that the acid terminal groups promote the penetration of water in the outer part of the organic film.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Gabriel ScallietClaire LionnetMickaël Le BechecLaurence DutronJean-Louis MagnardSylvie BaudinoVéronique BergougnouxFrédéric JullienPierre ChambrierPhilippe VergneChristian DumasJ. Mark CockPhilippe Hugueney
• Organismes : Laboratoire de Biotechnologies Végétales appliquées aux Plantes Aromatiques et Médicinales
• Publié dans Plant Physiology le 31/10/2020

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Résumé : Abstract Orcinol O-methyltransferase (OOMT) 1 and 2 catalyze the last two steps of the biosynthetic pathway leading to the phenolic methyl ether 3,5-dimethoxytoluene (DMT), the major scent compound of many rose (Rosa x hybrida) varieties. Modern roses are descended from both European and Chinese species, the latter being producers of phenolic methyl ethers but not the former. Here we investigated why phenolic methyl ether production occurs in some but not all rose varieties. In DMT-producing varieties, OOMTs were shown to be localized specifically in the petal, predominanty in the adaxial epidermal cells. In these cells, OOMTs become increasingly associated with membranes during petal development, suggesting that the scent biosynthesis pathway catalyzed by these enzymes may be directly linked to the cells' secretory machinery. OOMT gene sequences were detected in two non-DMT-producing rose species of European origin, but no mRNA transcripts were detected, and these varieties lacked both OOMT protein and enzyme activity. These data indicate that up-regulation of OOMT gene expression may have been a critical step in the evolution of scent production in roses.

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• Type de publi. : Autre publication
• Date de publi. : 01/01/2006
• Auteurs : Reiner BraunHeino FalckeR. FenderJean-Mathias GriessmeierP. JonkerM. KrämerSera MarkoffJames C. Miller-JonesR. A. OstenR. A. OstenHanno SpreeuwBenjamin W. StappersRudy WijnandsRalph A. M. J. WijersMichael W. WisePhilippe Zarka
• Organismes : Laboratoire d'études spatiales et d'instrumentation en astrophysique

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Stéphane RoudnitzkyPhilippe DruaultPhilippe Guibert
• Organismes : Institut Jean Le Rond d'Alembert Institut Jean Le Rond d'Alembert
• Publié dans Journal of Turbulence le 22/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : François M. KleinclaussSylvain PerrucheEmeline MassonMarcelo de Carvalho-BittencourtSabeha BiichleJean-Paul Remy-MartinChristophe FerrandMael MartinHugues BittardJean-Marc ChalopinEstelle SeillesPierre TiberghienPhilippe Saas
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
• Publié dans Cell Death and Differentiation le 29/10/2020

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Résumé : Apoptotic leukocytes are endowed with immunomodulatory properties that can be used to enhance hematopoietic engraftment and prevent graft-versus-host disease (GvHD). This apoptotic cell-induced tolerogenic effect is mediated by host macrophages and not recipient dendritic cells or donor phagocytes present in the bone marrow graft as evidenced by selective cell depletion and trafficking experiments. Furthermore, apoptotic cell infusion is associated with TGF-beta-dependent donor CD4+CD25+ T-cell expansion. Such cells have a regulatory phenotype (CD62L(high) and intracellular CTLA-4+), express high levels of forkhead-box transcription factor p3 (Foxp3) mRNA and exert ex vivo suppressive activity through a cell-to-cell contact mechanism. In vivo CD25 depletion after apoptotic cell infusion prevents the apoptotic cell-induced beneficial effects on engraftment and GvHD occurrence. This highlights the role of regulatory T cells in the tolerogenic effect of apoptotic cell infusion. This novel association between apoptosis and regulatory T-cell expansion may also contribute to preventing deleterious autoimmune responses during normal turnover.

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Fichiers liés : F_Kleinclauss_Cell_Death_Differ_200-2.pdf inserm-00473141_edited.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : J.V. BrugniauxLaurent SchmittPaul RobachGérard NicoletJean-Pierre FouillotStéphane MoutereauFrançoise LasneVincent PialouxPhilippe SaasMarie-Claude ChorvotJérémy CornoloNiels V. OlsenJean-Paul Richalet
• Organismes : Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Image et ville Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Centre national de ski nordique et de moyenne montagne [Composante de l'École nationale des sports de montagne (ENSM)] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Service de Biochimie [Mondor] Agence Française de Lutte contre le Dopage Laboratoire de Physiologie-Biologie du Sport Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Department of Pharmacology and Pharmacotherapy [Copenhagen] Réponses Cellulaires et Fonctionnelles à l'Hypoxie
• Publié dans Journal of Applied Physiology le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Aysen TezcanerDavid HicksFouzia BoulmedaisJosé-Alain SahelPierre SchaafJean-Claude VoegelPhilippe Lavalle
• Organismes : Department of Engineering Sciences [Ankara] Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Biomatériaux : Processus biophysiques et biologiques aux interfaces Laboratoire de Physiopathologie Cellulaire et Moleculaire de la Retine Institut de la Vision Institut Charles Sadron Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces
• Publié dans Biomacromolecules le 28/10/2020

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Résumé : Reconstruction of extracellular matrix substrates for delivery of functional photoreceptors is crucial in pathologies such as retinal degeneration and age-related macular degeneration. In this study, we assembled polyelectrolyte films using the layer-by-layer deposition method. The buildup of three different films composed of poly(L-lysine)/chondroitin sulfate (PLL/CSA), poly(L-lysine)/poly(styrenesulfonate) (PLL/PSS), or poly(L-lysine)/hyaluronic acid (PLL/HA) was followed by means of quartz crystal microbalance measurements, optical waveguide light mode spectroscopy, confocal microscopy, and atomic force microscopy. The exponential growth regime and the diffusion of PLL chains from the bulk through the PLL/CSA, PLL/PSS, and PLL/HA films was examined. Evaluation of photoreceptor cell viability was optimal on one layer of PLL (PLL(1)), followed by 10 bilayers of PLL/HA [(PLL/HA)(10)] and 10 bilayers of PLL/CSA [(PLL/CSA)(10)]. The number of bilayers and the type of terminating layer also had a significant influence on the number of photoreceptor cells attached. Functionalized polyelectrolyte multilayer films were obtained by adsorbing basic fibroblastic factor (bFGF) or the insoluble fraction of interphotoreceptor matrix (IPM) on or within polyelectrolyte multilayers. bFGF and IPM adsorption on top of the (PLL/CSA)(10)/PLL polyelectrolyte films increased the number of photoreceptor cells attached and maintained the differentiation of rod and cone cells.

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Fichiers liés : Biomacromolecules_revised_.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Philippe ThomasFabrice LallouéPierre-Marie PreuxCyril Hazif-ThomasSylvie ParielRobcis InscaleJoël BelminJean-Pierre Clément
• Organismes : Centre de Mémoire de Ressources et de Recherches [Limoges] Homéostasie Cellulaire et Pathologies Laboratoire de Biostatistique et d'Informatique Médicale Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] CHRU Brest - Psychiatrie Adulte CHU Charles Foix [AP-HP] CHU Charles Foix [AP-HP] Centre de Mémoire de Ressources et de Recherches [Limoges] Neuroépidémiologie Tropicale et Comparée Service de Psychiatrie [CHU Limoges]
• Publié dans International Journal of Geriatric Psychiatry le 25/10/2020

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Résumé : BACKGROUND: Alzheimer's disease and related syndromes have heavy social and human consequences for the patient and his family. Beyond the neuropsychiatric effects of specific therapies for dementia, one of today's challenges is the quality of life for both patients and their informal caregivers. OBJECTIVES: This survey tends to determine parameters influencing caregivers' quality of life, and its possible link with patients' quality of life. METHODS: A scale measuring caregivers' quality of life, developed from data from previous PIXEL studies was used. It is a questionnaire composed of 20 items. The scale was related to the socio-demographic data of both patients and their main caregivers, to the ADRQL scale (Alzheimer Disease Related Quality Life) of Rabins for the QoL of dementia patients, to the patients medical and therapeutic data, specially a neuropsychological inventory: Folstein's cognition test, Cornell's depression scale, the fast battery of frontal assessment, Katz's dependence index, Cummings' neuropsychiatric inventory for behavioral and psychological symptoms of dementia and to a physician evaluation of caregiver's depression. RESULTS: One hundred patients diagnosed with dementia who live at home with their principal caregivers were recruited for this survey. Patients were 80.2 +/- 6.8 years old and caregivers were 65.7 +/- 12.8 years old. The caregivers' quality of life was correlated to the quality of life of the patients they cared for, the importance of behavioral disorders, and the duration of dementia evolution. Women caregivers had a worse quality of life and were more depressive than men. DISCUSSION: Caregivers' and patients' quality of life are related and both share a community of distress.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : J.V. BrugniauxL. SchmittPaul RobachGérard NicoletJean-Pierre FouillotStéphane MoutereauFrançoise LasneVincent PialouxPhilippe SaasMarie-Claude ChorvotJérémy CornoloNiels V. OlsenJean-Paul Richalet
• Organismes : Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Centre national de ski nordique et de moyenne montagne [Composante de l'École nationale des sports de montagne (ENSM)] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Département Médical Centre national de ski nordique et de moyenne montagne [Composante de l'École nationale des sports de montagne (ENSM)] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Service de Biochimie [Mondor] Laboratoire National de Dépistage du Dopage Laboratoire de Physiologie-Biologie du Sport Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Department of Pharmacology and Pharmacotherapy [Copenhagen] Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire
• Publié dans Journal of Applied Physiology le 02/11/2020

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Résumé : The efficiency of "living high, training low" (LHTL) remains controversial, despite its wide utilization. This study aimed to verify whether maximal and/or submaximal aerobic performance were modified by LHTL and whether these effects persist for 15 days after returning to normoxia. Last, we tried to elucidate whether the mechanisms involved were only related to changes in oxygen-carrying capacity. Eleven elite middle-distance runners were tested before (Pre), at the end (Post1), and 15 days after the end (Post2) of an 18-day LHTL session. Hypoxic group (LHTL, n = 5) spent 14 h/day in hypoxia (6 nights at 2,500 m and 12 nights at 3,000 m), whereas the control group (CON, n = 6) slept in normoxia (1,200 m). Both LHTL and CON trained at 1,200 m. Maximal oxygen uptake and maximal aerobic power were improved at Post1 and Post2 for LHTL only (+7.1 and +3.4% for maximal oxygen uptake, +8.4 and +4.7% for maximal aerobic power, respectively). Similarly oxygen uptake and ventilation at ventilatory threshold increased in LHTL only (+18.1 and +12.2% at Post1, +15.9 and +15.4% at Post2, respectively). Heart rate during a 10-min run at 19.5 km/h decreased for LHTL at Post2 (-4.4%). Despite the stimulation of erythropoiesis in LHTL shown by the 27.4% increase in serum transferrin receptor and the 10.1% increase in total hemoglobin mass, red cell volume was not significantly increased at Post1 (+9.2%, not significant). Therefore, both maximal and submaximal aerobic performance in elite runners were increased by LHTL mainly linked to an improvement in oxygen transport in early return to normoxia and probably to other process at Post2.

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