Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Frédéric MarchalDominique EliasPhilippe RauchRasa ZarnegarAgnès LerouxJoseph StinèsJean-Luc VerhaegheFrançois GuilleminJean-Pierre CarteauxJean-Pierre Villemot
• Organismes : Centre Alexis Vautrin Institut Gustave Roussy Centre Alexis Vautrin Institut Gustave Roussy Centre Alexis Vautrin Centre Alexis Vautrin Centre Alexis Vautrin Centre Alexis Vautrin Centre de Recherche en Automatique de Nancy Centre Alexis Vautrin Chirurgie Expérimentale
• Publié dans Annals of Surgery le 26/10/2020

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Résumé : OBJECTIVE: To prevent bile duct injury by using a cold 5% glucose isotonic solution cooling in the bile ducts when radiofrequency (RF) is performed in a porcine model. SUMMARY BACKGROUND DATA: Complications that may arise during liver RF ablation include biliary stenosis and abscesses. METHODS: The RITA 1500 generator was used for the experiments. Two lesions were performed in the left liver. The pigs were killed 1 or 3 weeks after the procedure. An ex vivo cholangiogram was obtained by direct injection into the main bile duct. Samples of RF lesions, of liver parenchyma near and at a distance from the RF lesions, underwent pathologic studies. Two groups of 20 pigs each were treated: one without perfusion of the bile ducts and the other with perfusion of cold 5% glucose isotonic solution into the bile ducts. The Pringle maneuver was used in 50% of the RF procedures. Radiologic lesions were classified as biliary stenosis, complete interruption of the bile duct, or extravasation of the radiologic contrast liquid. RESULTS: Histologic lesions of the bile ducts were observed near the ablated RF lesion site and at a distance from the RF lesions when a Pringle maneuver was performed. Radiologic and histologic lesions of the bile ducts were significantly reduced (P < 0.0001) when the bile ducts were cooled. CONCLUSIONS: Cooling of the bile ducts with a cold 5% glucose isotonic solution significantly protects the intrahepatic bile ducts from damages caused by the heat generated by RF when performed close to the bile ducts.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Stéphane RoudnitzkyPhilippe DruaultPhilippe Guibert
• Organismes : Institut Jean Le Rond d'Alembert Institut Jean Le Rond d'Alembert
• Publié dans Journal of Turbulence le 22/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2006
• Auteurs : Jean-Philippe PerninAnne Lejeune
• Organismes : Modèles et Technologies pour l’Apprentissage Humain Modèles et Technologies pour l’Apprentissage Humain

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Résumé : no abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Fabienne LaugerettePatricia Passilly-DegraceBruno PatrisIsabelle NiotJean-Pierre MontmayeurPhilippe Besnard
• Organismes : Centre des Sciences du Goût Centre des Sciences du Goût Centre des Sciences du Goût Centre des Sciences du Goût Centre des Sciences du Goût Centre des Sciences du Goût
• Publié dans Médecine/Sciences le 25/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2006
• Auteurs : Jean-Philippe PerninAnne Lejeune
• Organismes : Modèles et Technologies pour l’Apprentissage Humain Modèles et Technologies pour l’Apprentissage Humain

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Résumé : no abstract

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Aude PicardPhilippe OgerIsabelle DanielHervé CardonGilles MontagnacJean-Claude Chervin
• Organismes : Laboratoire de Sciences de la Terre Laboratoire de Sciences de la Terre Laboratoire de Sciences de la Terre Laboratoire de Sciences de la Terre Laboratoire de Sciences de la Terre Institut de minéralogie et de physique des milieux condensés
• Publié dans Journal of Applied Physics le 02/11/2020

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Résumé : We present an optical pressure sensor suitable for experiments in diamond anvil cell in the 0.1 MPa–2 GPa pressure range, for temperatures between ambient and 323 K. It is based on the pressure-dependent fluorescence spectrum of FluoSpheres®, which are commercially available fluorescent microspheres commonly used to measure blood flow in experimental biology. The fluorescence of microspheres is excited by the 514.5 nm line of an Ar+ laser, and the resulting spectrum displays three very intense broad bands at 534, 558, and 598 nm, respectively. The reference wavelength and pressure gauge is that of the first inflection point of the spectrum, located at 525.6±0.2 nm at ambient pressure. It is characterized by an instantaneous and large linear pressure shift of 9.93(±0.08) nm/GPa. The fluorescence of the FluoSpheres® has been investigated as a function of pressure (0.1–4 GPa), temperature (295–343 K), pH (3–12), salinity, and pressure transmitting medium. These measurements show that, for pressures comprised between 0.1 MPa and 2 GPa, at temperatures not exceeding 323 K, at any pH, in aqueous pressure transmitting media, pressure can be calculated from the wavelength shift of two to three beads, according to the relation P=0.100 (±0.001) Deltalambdai(P) with Deltalambdai(P)=lambdai(P)–lambdai(0) and lambdai(P) as the wavelength of the first inflection point of the spectrum at the pressure P. This pressure sensor is approximately thirty times more sensitive than the ruby scale and responds instantaneously to pressure variations.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Gaelle DauriatHervé MalGabriel ThabutJean-François MornexMichelle BertocchiFrançois TroncFrançois Leroy-LaduriePhilippe DartevelleMartine Reynaud-GaubertPascal ThomasChristophe PisonDominique BlinMarc SternPierre BonnetteClaire DromerJean-Francois VellyOlivier BrugièreGuy LesècheMichel Fournier
• Organismes : Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Rétrovirus et Pathologie Comparée Hospices Civils de Lyon Hospices Civils de Lyon Hospices Civils de Lyon Centre Chirurgical Marie Lannelongue Centre Chirurgical Marie Lannelongue Assistance Publique - Hôpitaux de Marseille Assistance Publique - Hôpitaux de Marseille CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Hôpital Foch [Suresnes] Hôpital Foch [Suresnes] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP)
• Publié dans Transplantation le 25/10/2020

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Résumé : Background. Lung transplantation (LT) may represent a therapeutic option in case of advanced pulmonary Langerhans' cell histiocytosis (PLCH). Little is known however about the characteristics of the patients considered for LT or its results. Methods. We conducted a retrospective multicenter study by questionnaire on 39 patients who underwent LT for end-stage PLCH at seven centers in France. Results. Of the 39 patients, 15 received single lung transplantation, 15 double lung transplantation and 9 heart-lung transplantation. At evaluation, extrapulmonary involvement was present in 31% of the patients, pulmonary hypertension (PAPm > 25 mm Hg) was observed in 92% of cases and was moderate-to-severe (PAPm >= 35 mm Hg) in 72.5%. The survival was 76.9% at 1 year, 63.6% at 2 years, 57.2% at 5 years, and 53.7% at 10 years. Recurrence of the disease occurred in eight cases (20.5%) with no impact on the survival rate. The sole risk factor for recurrence of the disease was the presence of preoperative extrapulmonary involvement. Conclusion. Severe pulmonary hypertension is a common feature in patients with end-stage PLCH. Given the good postransplant survival rate and despite a recurrence rate of the disease of approximately 20% after LT, we conclude that LT is a therapeutic option in this setting.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Laurence Goux-CapesArianna FiloramoDenis CôteJean-Philippe BourgoinJean-Noël Patillon
• Organismes : Laboratoire d'Electronique Moléculaire Laboratoire d'Electronique Moléculaire Laboratoire Pierre Aigrain Laboratoire d'Electronique Moléculaire Laboratoire d'Electronique Moléculaire
• Publié dans Physica Status Solidi A (applications and materials science) le 25/10/2020

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Résumé : We present a simple and versatile method for linking single wall carbon nanotubes (SWNT) together through DNA by non-covalent chemistry using streptavidin-biotin recognition complex. Streptavidin coated SWNTs are reacted with biotin or bis-biotin ended DNA double strands leading to SWNT-DNA and SWNT-DNA-SWNT adducts in high yield. This method avoids strong acidic treatment of SWNTs prior to functionalization as usually required in covalent routes. Complementary characterizations by gel electrophoresis and AFM demonstrated the efficiency of the present binding method. In addition, SWNTs bound to DNA can be aligned on a substrate using the combing properties of DNA strands, bringing a new tool into the toolkit for self-assembling SWNTs onto surfaces.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2006
• Auteurs : Alice BerthelotIvan FaveroGuillaume CassaboisChristophe VoisinClaude DelalandePhilippe RoussignolRobson FerreiraJ.-M. Gérard
• Organismes : Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Laboratoire Pierre Aigrain Nanophysique et Semiconducteurs
• Publié dans Nature Physics le 01/11/2020

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Résumé : Motional narrowing refers to the striking phenomenon where the resonance line of a system coupled to a reservoir becomes narrower when increasing the reservoir fluctuation. A textbook example is found in nuclear magnetic resonance, where the fluctuating local magnetic fields created by randomly oriented nuclear spins are averaged when the motion of the nuclei is thermally activated. The existence of a motional narrowing effect in the optical response of semiconductor quantum dots remains so far unexplored. This effect may be important in this instance since the decoherence dynamics is a central issue for the implementation of quantum information processing based on quantum dots. Here we report on the experimental evidence of motional narrowing in the optical spectrum of a semiconductor quantum dot broadened by the spectral diffusion phenomenon. Surprisingly, motional narrowing is achieved when decreasing incident power or temperature, in contrast with the standard phenomenology observed for nuclear magnetic resonance.

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Fichiers liés : Cassabois_Nature_old.pdf

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• Type de publi. :
• Date de publi. : 01/01/2006
• Auteurs : Philippe AurierJean-Pierre Couderc
• Organismes : Université Montpellier 2 - Sciences et Techniques Marchés, Organisations, Institutions et Stratégies d'Acteurs

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Résumé : Le résultat majeur, du point de vue des stratégies de marque, est que seulement 40 % des EAA utilisent une stratégie de marque propre en 2002, contre 61% en 1997, ceci au profit d’une forte progression des EAA commercialisant sans marque. Cette évolution s’accompagne d’une hausse du taux d’incorporation de MPA caractérisant une « basification » de la production et une baisse de leur taux de création de valeur ajoutée ainsi qu’un recentrage sur les activités de production, au détriment des activités marketing et commerciale. Les EAA languedociennes, se transformeraient en sous traitants d’entreprises plus importantes, aux centres de décision localisés hors région, et ayant la taille nécessaire permettant de réaliser des économies d’échelle au plan commercial (possession d’une force de vente propre) et marketing (gestion d’une marque forte). Néanmoins, l’utilisation d’une marque propre couplée à un signe d’origine géographique (AOC, autres dénominations telles que les IGP), constitue une voie de développement intéressante. Les meilleures performances sont souvent observées avec l’utilisation de la stratégie conjuguant la présence d’une marque propre et d’un signe géographique.

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