Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2005
• Auteurs : Elisabeth GiacobinoJean-Philippe KarrAugustin BaasGaëtan MessinMarco RomanelliAlberto Bramati
• Organismes : Laboratoire Kastler Brossel Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Institute of Condensed Matter Physics [Lausanne] Laboratoire Charles Fabry de l'Institut d'Optique / Optique quantique Institut de Physique de Rennes Laboratoire Kastler Brossel
• Publié dans Solid State Communications le 31/10/2020

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Résumé : The non-linear emission from semiconductor microcavities in the strong coupling regime exhibits specific coherence properties that can be interpreted by parametric polariton four-wave mixing. In a geometry corresponding to degenerate four-wave mixing, we predict and observe a phase dependence of the amplification which is a signature of a coherent polariton wave mixing process. This process is also expected to lead to bistability and squeezed light generation. Spatial effects in the non-linear regime are evidenced, and spatial filtering is required in order to optimize the measured squeezing which is observed close to the bistability turning point. Moreover, the presence of strong coupling inside the microcavity allows to produce a new type of squeezing involving a part-light, part-matter field, the polariton.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2005
• Auteurs : Philippe DussartGaëlle CartetPierre HuguetNicolas LévêqueChristian HajjarJacques MorvanJulie VanderkerckhoveKarine FerretBruno LinaJean-Jacques ChomelHelene Norder
• Organismes : Institut Pasteur de la Guyane Centre National de Référence des Entérovirus Service d'Ophtalmologie Centre National de Référence des Entérovirus Service d'Ophtalmologie Institut Pasteur de la Guyane Institut Pasteur de la Guyane Service de Santé des Armées Centre National de Référence des Entérovirus Centre National de Référence des Entérovirus Centre National de Référence des Entérovirus
• Publié dans Journal of Medical Virology le 25/10/2020

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Résumé : An outbreak of acute hemorrhagic conjunctivitis occurred in French Guiana between April and July 2003, with approximately 6,000 cases in the two major cities Kourou and Cayenne. Since acute hemorrhagic conjunctivitis is not a notifiable disease in France, there was no registration of the number of cases. Therefore, these were estimated by comparing the consumption of antibiotic eye drops and ophthalmic ointments during 2002 and 2003. The outbreak rapidly spread into the Caribbean Islands, causing an outbreak in Guadeloupe in October. Viral isolates from conjunctival swabs of 16 patients were confirmed to be enterovirus by PCR directed to the 5' UTR of the genome. The isolates could not be neutralized by the Melnick intersecting pools, but were shown to be CV-A24 variant by limited sequencing within the VP1 and 3C regions of 12 strains. Phylogenetic analysis revealed that they were similar to the genotype III strains causing outbreaks in Korea 2002 and Malaysia 2003. The previous outbreak of conjunctivitis caused by CV-A24 in the Caribbean in the 1980s was also introduced from Asia, and disappeared after 3 years. This new introduction from Asia and its rapid spread into the Caribbean, where the infection disappeared after a few months, indicates that the CV-A24 variant has a different epidemiological pattern in this region compared to South East Asia, since it has not established an endemic infection. It had to be reintroduced from Asia, where it has been circulating since the 1970s.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2005
• Auteurs : Louis-Philippe Corbeil-GirardArnaud F. KleinA. Marie-Josée SassevilleHugo LavoieMarie-Josée DicaireAnik Saint-DenisMartin PagéAndré DuranceauFrançois CodèreJean-Pierre BouchardGeorge KarpatiGuy A RouleauBernard MassieYves LangelierBernard Brais
• Organismes : Laboratoire de Neurogénétique Laboratoire de Neurogénétique Laboratoire de Neurogénétique Laboratoire de Neurogénétique Laboratoire de Neurogénétique Laboratoire de Neurogénétique Laboratoire de Neurogénétique McGill University Health Center [Montreal] McGill University Health Center [Montreal] McGill University Health Center [Montreal] CRCHUM-Notre-Dame Hospital Laboratoire de Neurogénétique
• Publié dans Neurobiology of Disease le 23/10/2020

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Résumé : Oculopharyngeal muscular dystrophy (OPMD) is an adult-onset disease caused by expanded (GCN) 12-17 stretches encoding the Nterminal polyalanine domain of the poly(A) binding protein nuclear 1 (PABPN1). OPMD is characterized by intranuclear inclusions (INIs) in skeletal muscle fibers, which contain PABPN1, molecular chaperones, ubiquitin, proteasome subunits, and poly(A)-mRNA. We describe an adenoviral model of PABPN1 expression that produces INIs in most cells. Microarray analysis revealed that PABPN1 overexpression reproducibly changed the expression of 202 genes. Sixty percent of upregulated genes encode nuclear proteins, including many RNA and DNA binding proteins. Immunofluorescence microscopy revealed that all tested nuclear proteins encoded by eight upregulated genes colocalize with PABPN1 within the INIs: CUGBP1, SFRS3, FKBP1A, HMG2, HNRPA1, PRC1, S100P, and HSP70. In addition, CUGBP1, SFRS3, and FKBP1A were also found in OPMD muscle INIs. This study demonstrates that a large number of nuclear proteins are sequestered in OPMD INIs, which may compromise cellular function.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2005
• Auteurs : Julien VermotBrigitte SchuhbaurHervé Le MouellicPeter MccafferyJean-Marie GarnierDidier HentschPhilippe BrûletKaren NiederreitherPierre ChambonPascal DolléIsabelle Le Roux
• Organismes : Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire
• Publié dans Development (Cambridge, England) le 02/11/2020

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Résumé : Retinoic acid (RA) activity plays sequential roles during the development of the ventral spinal cord. Here, we have investigated the functions of local RA synthesis in the process of motoneuron specification and early differentiation using a conditional knockout strategy that ablates the function of the retinaldehyde dehydrogenase 2 (Raldh2) synthesizing enzyme essentially in brachial motoneurons, and later in mesenchymal cells at the base of the forelimb. Mutant (Raldh2L-/-) embryos display an early embryonic loss of a subset of Lim1+ brachial motoneurons, a mispositioning of Islet1+ neurons and inappropriate axonal projections of one of the nerves innervating extensor limb muscles, which lead to an adult forepaw neuromuscular defect. The molecular basis of the Raldh2L-/- phenotype relies in part on the deregulation of Hoxc8, which in turn regulates the RA receptor RARbeta. We further show that Hoxc8 mutant mice, which exhibit a similar congenital forepaw defect, display at embryonic stages molecular defects that phenocopy the Raldh2L-/- motoneuron abnormalities. Thus, interdependent RA signaling and Hox gene functions are required for the specification of brachial motoneurons in the mouse.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2005
• Auteurs : Louis-Philippe Corbeil-GirardArnaud F. KleinA. Marie-Josée SassevilleHugo LavoieAnik Saint-DenisMartin PagéAndré DuranceauFrançois CodèreJean-Pierre BouchardGeorge KarpatiGuy RouleauBernard MassieYves LangelierBernard Brais
• Organismes : Laboratoire de Neurogénétique Laboratoire de Neurogénétique CEVE GT12 Laboratoire National d’Hydraulique et Environnement McGill University = Université McGill [Montréal, Canada] CRCHUM-Notre-Dame Hospital Laboratoire de Neurogénétique
• Publié dans Neurobiology of Disease le 23/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/04/2005
• Auteurs : Maylis TartasPhilippe BouyéAudrey KoïtkaSylvain DurandYves GalloisJean Louis SaumetPierre Abraham
• Organismes : UPRES EA 2170 Circulations régionales et microcirculation Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques Biologie Neurovasculaire Intégrée Centre Hospitalier Universitaire d'Angers
• Publié dans AJP - Heart and Circulatory Physiology le 26/10/2020

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• Type de publi. : Communication dans un congrès
• Date de publi. : 18/03/2005
• Auteurs : Jean-Claude DesportPhilippe CouratierPierre-Marie PreuxPatrick Carrier
• Organismes : Neuroépidémiologie Tropicale et Comparée Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Service de Neurologie [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Laboratoire de Biostatistique et d'Informatique Médicale Neuroépidémiologie Tropicale et Comparée Biologie moléculaire et cellulaire des microorganismes

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• Type de publi. : Article dans une revue
• Date de publi. : 15/03/2005
• Auteurs : Jean-Philippe KarrSenem KilicLaurent Hilico
• Organismes : Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry) Laboratoire Kastler Brossel Département de Physique et Modélisation (Evry)
• Publié dans Journal of Physics B: Atomic, Molecular and Optical Physics le 26/10/2020

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Résumé : We present a fully exact non-relativistic calculation of the energies and wavefunctions of the J=1 states of the HD+ molecular ion. The energies are obtained with a very high accuracy of 10-14 au, representing for most levels, an improvement by several orders of magnitude over previous calculations. We compute the static polarisabilities of the J=0 states, which are in agreement with the literature, with an improved accuracy, as well as the two-photon transition probabilities and light shifts between J=0 states. Finally, we extend our study to transitions between higherJ states, using an approximate expression of the transition probability, and discuss the feasibility of a two-photon spectroscopy experiment in HD+.

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• Type de publi. : Article dans une revue
• Date de publi. : 03/03/2005
• Auteurs : Christian GachetJean‐pierre CazenavePhilippe OhlmannGerhard HilfThomas WielandKarl Jakobs
• Organismes : Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose
• Publié dans European Journal of Biochemistry le 23/10/2020

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Résumé : ADP receptor‐regulated binding of the labeled GTP analog, guanosine 5′‐ O ‐(3‐[ 35 S]thiotriphosphate) ([ 35 S]GTP[γS]), to guanine‐nucleotide‐binding proteins (G proteins) was studied in human platelet membranes. The potent ADP receptor agonist, 2‐methyl‐thio‐adenosine 5′‐diphosphate (2MeSADP), a non‐hydrolyzable analog of ADP, increased the binding of [ 35 S]GTP[γS] without apparent lag phase. Under optimal conditions, i.e. in the presence of GDP (1–10 μM), 2MeSADP increased the binding up to about threefold, with half‐maximal and maximal increase observed at 10 nM and 1 μM 2MeSADP, respectively. ADP itself increased the binding of [ 35 S]GTP[γS] by maximally about twofold, with half‐maximal increase occurring at 0.1 μM ADP. The agonist‐induced stimulation was competitively antagonized by the ADP receptor(s) antagonist, (1 S )‐adenosine 5′‐ O ‐(1‐thiotriphosphate) {( S p)‐ATP[αS]}. Other platelet receptor agonists known to act through receptors coupled to G proteins also increased binding of [ 35 S]GTP[γS] in human platelet membranes, but without being inhibited by ( S p)‐ATP[αS]. The data presented indicate that the platelet ADP receptor(s) can interact with and efficiently activate G proteins, the nature of which remains to be identified.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2005
• Auteurs : Yves ChantalPierre RobinJean-Philippe VernatIouri Bernache-Assollant
• Organismes : Handicap, Activité, Vieillissement, Autonomie, Environnement
• Publié dans Psychology of Sport and Exercise le 26/10/2020

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