Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Brigitte GranelChristophe ChevillardYannick AllanoreViolaine ArnaudSandrine CabantousSandrine MarquetPierre-Jean WeillerJean-Marc DurandJean-Robert HarléClaire GrangeYves FrancesPhilippe BerbisJean GaudartPhilippe de MiccoAndré KahanAlain Dessein
• Organismes : Hôpital Nord [CHU - APHM] Génétique et immunologie des maladies parasitaires Service de rhumatologie [CHU Cochin] UNIROUEN - UFR Santé Institut de biologie et chimie des protéines [Lyon] Génétique et immunologie des maladies parasitaires Service de Médecine Interne Hôpital Edouard Herriot [CHU - HCL] Service de Chirurgie Centre de Recherche Roland Mousnier Histoire et Civilisation Service de Médecine interne [CHU Saint-Etienne] Hôpital Nord [CHU - APHM] Laboratoire d'informatique Fondamentale de Marseille - UMR 6166 Anthropologie bio-culturelle, Droit, Ethique et Santé Service de rhumatologie [CHU Cochin] Génétique et immunologie des maladies parasitaires
• Publié dans Immunogenetics le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Jamal BamoulidCécile CourivaudMarina DeschampsPatricia MercierChristophe FerrandAlfred PenfornisPierre TiberghienJean-Marc ChalopinPhilippe SaasDidier Ducloux
• Organismes : Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Service de Diabétologie - Endocrinologie [CHRU Besançon] Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Centre d'Investigation Clinique de Besançon Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Plateforme de Biomonitoring Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) Service d'urologie, andrologie et transplantation rénale Centre d'Investigation Clinique de Besançon
• Publié dans Journal of the American Society of Nephrology le 26/10/2020

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Résumé : New-onset diabetes after transplantation (NODAT) is a serious complication of transplantation. This study tested whether IL-6 production capacity may influence the development of NODAT in two different groups of patients. The occurrence of NODAT was analyzed with respect to IL-6 gene promoter polymorphism at position -174 (G-->C) and other relevant risk factors retrospectively in 217 renal transplant recipients and prospectively in 132. A linear increase in both circulating IL-6 (P = 0.09) and C-reactive protein (an indicator of basal IL-6 secretion; P = 0.03) concentrations from the CC genotype to the GG genotype was observed. In the multivariate model, the CC genotype was associated with a decreased risk for NODAT compared with the GG genotype in the two cohorts. Homeostasis Model Assessment for Insulin Resistance also revealed lesser insulin sensitivity in the GG carriers than in the CC carriers (2.15 +/- 2 versus 1.32 +/- 1.03; P = 0.03). Subgroup analysis showed that the influence of IL-6 gene promoter polymorphism on the development of NODAT was restricted mostly to overweight patients. These results highly suggest that IL-6 production capacity influences the development of NODAT and that diabetes-inducing drug administration should be limited in overweight patients who carry the GG genotype.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Jean-Claude DesportPhilippe CouratierPierre-Marie Preux
• Organismes : Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Neuroépidémiologie Tropicale et Comparée Université de Limoges Neuroépidémiologie Tropicale et Comparée Université de Limoges Neuroépidémiologie Tropicale et Comparée Université de Limoges
• Publié dans Clinical Nutrition le 30/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Constant VodouhêErell Le GuenJuan Mendez GarzaGregory FranciusChristophe DéjugnatJoëlle OgierPierre SchaafJean-Claude VoegelPhilippe Lavalle
• Organismes : Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Max Planck Institute of Colloids and Interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces Institut Charles Sadron Biomatériaux : Processus biophysiques et biologiques aux interfaces Biomatériaux : Processus biophysiques et biologiques aux interfaces
• Publié dans Biomaterials le 28/10/2020

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Résumé : A surface coating based on polylysine/hyaluronic acid multilayers was designed and acted as a reservoir for an antiproliferative agent, paclitaxel (Taxol). Absolutely no chemical modification of polyelectrolytes or of the drug was needed and the final architecture was obtained in an extremely simple way using the layer-by-layer method. The paclitaxel dose available for human colonic adenocarcinoma cells HT29 seeded on the films could be finely tuned. Moreover, the accessibility of the drugs was controlled by adding on the top of the drug reservoir a capping made of synthetic polyelectrolyte multilayers. This capping was also required to allow adhesion of HT29 cells. Paclitaxel activity was maintained after embedding in the polyelectrolyte multilayers and cellular viability could be reduced by about 80% 96 h after seeding. The strategy described in this paper could be valuable for various other drug/cell systems.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Rodolphe AntySoumeya BekriNathalie LucianiMarie-Christine Saint-PaulMoncef DahmanAntonio IannelliImed Ben AmorAline Staccini-MyxPierre-Michel HuetJean GugenheimJean-Louis SadoulYannick Le Marchand-BrustelAlbert TranPhilippe Gual
• Organismes : Centre méditerranéen de médecine moléculaire Centre Hospitalier Universitaire de Nice Hôpital Archet 2 [Nice] Université de Rouen Normandie Matière et Systèmes Complexes Service d'Anatomie et Cytologie Pathologiques Centre méditerranéen de médecine moléculaire Ecole Polytechnice Universitaire de Nice Pôle Digestif Service de Chirurgie Digestive / Centre de Transplantation Hépatique [CHU Nice] Hôpital Archet 2 [Nice] Signalisation moléculaire et obésité Centre méditerranéen de médecine moléculaire Centre méditerranéen de médecine moléculaire
• Publié dans The American Journal of Gastroenterology le 22/10/2020

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Résumé : C-Reactive Protein (CRP), a nonspecific marker of inflammation that is moderately elevated in obesity, metabolic syndrome (MS), and type 2 diabetes, has been proposed as a surrogate marker of nonalcoholic steatohepatitis (NASH). Its clinical usefulness in the diagnosis of NASH was evaluated in severely obese patients without or with MS, diabetes, and NASH and the potential roles of the liver and of the adipose tissue in CRP production were characterized.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : Philippe QuittetPatrice CeballosErnesto LopezZhao-Yang LuPascal LatryCatherine BechtÉric LegouffeNathalie FegueuxCarole ExbrayatDamien PouesselValérie RouilléJean-Pierre DaurèsBernard KleinJean-François Rossi
• Organismes : Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Unité de Thérapie Cellulaire Unité de Thérapie Cellulaire et Génique Immunopathologie des maladies tumorales et autoimmunes Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Service d'hématologie et oncologie médicale Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 Unité de Thérapie Cellulaire Unité de Thérapie Cellulaire et Génique Immunopathologie des maladies tumorales et autoimmunes Service d'hématologie et oncologie médicale Immunopathologie des maladies tumorales et autoimmunes
• Publié dans Bone Marrow Transplantation le 01/11/2020

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Résumé : The use of a combination of G-CSF and GM-CSF versus G-CSF alone, after cyclophosphamide (4 g/m2) was compared in two randomized phase III studies, including 120 patients. In study A, 60 patients received 5 x 2 microg/kg/day of G-CSF and GM-CSF compared to 5 mug/kg/day of G-CSF. In study B, 60 patients received 2.5 x 2 microg/kg/day G-CSF and GM-CSF compared to G-CSF alone (5 microg/kg/day). With the aim to collect at least 5 x 10(6)/kg CD34 cells in a maximum of three large volume leukapherises (LK), 123 LK were performed in study A, showing a significantly higher number of patients reaching 10 x 10(6)/kg CD34 cells (21/29 in G+GM-CSF arm vs 11/27 in G-CSF arm, P=0.00006). In study B, 109 LK were performed, with similar results (10/27 vs 15/26, P=0.003). In both the study, the total harvest of CD34 cells/kg was twofold higher in G-CSF plus GM-CSF group (18.3 x 10(6) in study A and 15.85 x 10(6) in study B) than in G-CSF group (9 x 10(6) in study A and 8.1 x 10(6) in study B), a significant difference only seen in multiple myeloma, with no significant difference in terms of mobilized myeloma cells between G-CSF and GM-CSF groups.

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Fichiers liés : G_GM_n120_version_3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : W. D. CollinsV. RamaswamyM. D. SchwarzkopfY.J. SunR. W. PortmannQinjun FuS. E. B. CasanovaJean-Louis DufresneD. W. FillmoreP. M. D. ForsterV. Y. GalinL. K. GoharW. J. IngramD. P. KratzMarie-Pierre LefebvreJ. LiPhilippe MarquetV. OinasY. TsushimaT. UchiyamaW. Y. Zhong
• Organismes : Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539)
• Publié dans Journal of Geophysical Research: Atmospheres le 24/10/2020

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Résumé : The radiative effects from increased concentrations of well-mixed greenhouse gases (WMGHGs) represent the most significant and best understood anthropogenic forcing of the climate system. The most comprehensive tools for simulating past and future climates influenced by WMGHGs are fully coupled atmosphere-ocean general circulation models (AOGCMs). Because of the importance of WMGHGs as forcing agents it is essential that AOGCMs compute the radiative forcing by these gases as accurately as possible. We present the results of a radiative transfer model intercomparison between the forcings computed by the radiative parameterizations of AOGCMs and by benchmark line-by-line (LBL) codes. The comparison is focused on forcing by CO2, CH4, N2O, CFC-11, CFC-12, and the increased H2O expected in warmer climates. The models included in the intercomparison include several LBL codes and most of the global models submitted to the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report (AR4). In general, the LBL models are in excellent agreement with each other. However, in many cases, there are substantial discrepancies among the AOGCMs and between the AOGCMs and LBL codes. In some cases this is because the AOGCMs neglect particular absorbers, in particular the near-infrared effects of CH4 and N2O, while in others it is due to the methods for modeling the radiative processes. The biases in the AOGCM forcings are generally largest at the surface level. We quantify these differences and discuss the implications for interpreting variations in forcing and response across the multimodel ensemble of AOGCM simulations assembled for the IPCC AR4.

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Fichiers liés : 2005JD006713.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2006
• Auteurs : William SzurhajEtienne LabytJean-Louis BourriezPhilippe KahanePatrick ChauvelFrançois MauguièrePhilippe Derambure
• Organismes : Noyaux gris centraux Noyaux gris centraux Noyaux gris centraux Laboratoire de physiopathologie de l'épilepsie Service de neurophysiologie clinique [Hôpital de la Timone - APHM] Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Noyaux gris centraux
• Publié dans European Journal of Neuroscience le 22/10/2020

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Résumé : Changes in sensorimotor rhythms (mu, beta and gamma) and movement-related cortical potentials (MRCPs) are both generated principally by the contralateral sensorimotor areas during the execution of self-paced movement. They appear to reflect movement control mechanisms, which remain partially unclear. With the aim of better understanding their sources and significance, we recorded MRCPs and sensorimotor rhythms during and after self-paced movement using intracerebral electrodes in eight epileptic subjects investigated by stereoelectroencephalography. The results showed that: (i) there is a strong spatial relationship between the late components of movement--the so-called motor potential (MP) and post-movement complex (PMc)--and gamma event-related synchronization (ERS) within the 40-60 Hz band, as the MP/PMc always occurred in contacts displaying gamma ERS (the primary sensorimotor areas), whereas mu and beta reactivities were more diffuse; and (ii) MPs and PMc are both generated by the primary motor and somatosensory areas, but with distinct sources. Hence, this could mean that kinesthesic sensory afferences project to neurons other than those firing during the pyramidal tract volley. The PMc and low gamma ERS represent two electrophysiological facets of kinesthesic feedback from the joints and muscles involved in the movement to the sensorimotor cortex. It could be suggested that gamma oscillations within the 40-60 Hz band could serve to synchronize the activities of the various neuronal populations involved in control of the ongoing movement.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/08/2006
• Auteurs : Alexandre SkrzypczackPierre SiohanJean-Philippe Javaudin
• Organismes : Institut d'Electronique et de Télécommunications de Rennes France Télécom Recherche & Développement France Télécom Recherche & Développement

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• Type de publi. : Communication dans un congrès
• Date de publi. : 31/07/2006
• Auteurs : Jordi FontJacqueline BoutinNicolas ReulPhilippe WaldteufelCarolina GabarróSonia ZineJoseph TenerelliFrançois PetitcolinJean-Luc Vergely
• Organismes : Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques

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