Philippe JEAN-PIERRE

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2005
• Auteurs : Stéphane GallandFrédéric GrimaudPhilippe BeauneJean−pierre Campagne
• Organismes : Département Systèmes Multi-Agents Département Méthodes Scientifiques pour la Gestion Industrielle Département Systèmes Multi-Agents Laboratoire de Productique et Informatique des systèmes manufacturiers Laboratoire d'Informatique pour l'Entreprise et les Systèmes de Production

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Résumé : We are located in the context of the industrial system simulation, which are complex and distributed in operational, informational and decisional terms. In this chapter, we present the problems and a methodological solution. This methodology is based on the systemic approach and on multi-agent systems. It allows the modelling of distributed industrial systems such as enterprise consortiums. Moreover, it proposes a software platform architecture whish is currently instanced with Arena and dedicated agents.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Nancy TerrierDavid GlissantJérôme GrimpletFrançois BarrieuPhilippe AbbalCarole CoutureAgnès AgeorgesRossitza AtanassovaCéline LéonJean-Pierre RenaudinFabienne DédaldéchampCharles RomieuSerge DelrotSaïd Hamdi
• Organismes : Sciences Pour l'Oenologie Transport des assimilats [UMR 6161] Sciences Pour l'Oenologie UMR 619 Equipe Biologie de la Vigne Sciences Pour l'Oenologie UMR 619 Equipe Biologie de la Vigne Sciences Pour l'Oenologie Transport des assimilats [UMR 6161] UMR 619 Equipe Biologie de la Vigne UMR 619 Equipe Biologie de la Vigne Transport des assimilats [UMR 6161] Sciences Pour l'Oenologie Transport des assimilats [UMR 6161] UMR 619 Equipe Biologie de la Vigne
• Publié dans Planta le 31/10/2020

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Résumé : The transition from a green, hard, and acidic pericarp to a sweet, soft, coloured, and sugar-rich ripe fruit occurs in many unrelated fruit species. High throughput identification of differentially expressed genes in grape berry has been achieved by the use of 50-mers oligoarrays bearing a set of 3,200 Unigenes from Vitis vinifera to compare berry transcriptome at nine developmental stages. Analysis of transcript profiles revealed that most activations were triggered simultaneously with softening, occurring within only 24 h for an individual berry, just before any change in colouration or water, sugar, and acid content can be detected. Although most dramatically induced genes belong to unknown functional categories, numerous changes occur in the expression of isogenes involved in primary and secondary metabolism during ripening. Focusing on isogenes potentially significant in development regulation (hormonal control of transcription factor) revealed a possible role for several hormones (cytokinin, gibberellin, or jasmonic acid). Transcription factor analysis revealed the induction of RAP2 and WRKY genes at veraison, suggesting increasing biotic and abiotic stress conditions during ripening. This observation was strengthened by an increased expression of multiple transcripts involved in sugar metabolism and also described as induced in other plant organs during stress conditions. This approach permitted the identification of new isogenes as possible control points: a glutathione S-transferase exhibits the same expression profile as anthocyanin accumulation and a new putative sugar transporter is induced in parallel with sugar import. Berries, collected from nine development stages (green to overripe) of the cv Shiraz (Vitis vinifera) and from two development stages (half-green and half-ripe) of the cvs Chardonnay and Cabernet Sauvignon, were used to detect differentially expressed genes; it was achieved by micro-array analysis developing 50-mer oligo arrays representing a set of 3,175 Unigenes from EST 3' sequencing of seven different libraries. Analysis of transcript profiles revealed a simultaneous activation of hundreds of genes at the berry softening, occurring within a shorter period of 48 h, and just before any change in color, water, sugar, and acid content. Although most induced genes belong to unknown functions, numerous changes occur in the expression of isogenes involved in primary and secondary ripening metabolism, in biotic and abiotic stress conditions and in hormonal control.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : K. WilhelmU. SchühleW. CurdtM. HilchenbachE. MarschPhilippe LemaireJean-Loup BertauxS.-D. JordanU. Feldman
• Organismes : Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Institut d'astrophysique spatiale Service d'aéronomie NASA Goddard Space Flight Center United States Naval Research Laboratory
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Spectral observations of the Sun in the vacuum-ultraviolet wavelength range by SUMER on SOHO led to the discovery of unusual emission features - called humps here - at 116.70 nm and 117.05 nm on either side of the He I 58.43 nm line. This resonance line is seen in the second order of diffraction, whereas the humps are recorded in the first order with the SUMER spectrometer. In its spectra both orders are superimposed. Two less pronounced humps can be detected at 117.27 nm and near 117.85 nm. After rejecting various possibilities of an instrumental cause of the humps, they are studied in different solar regions. Most of the measurements, in particular those related to the limb-brightening characteristics, indicate that the humps are not part of the background continuum. An assembly of spectrally-unresolved atomic or ionic emission lines might be contributing to the hump at 117.05 nm, but no such lines are known near 116.7 nm. It is concluded that we detect genuine radiation, the generation of which is not understood. A two-photon emission process, parametric frequency down conversion, and molecular emissions are briefly considered as causes of the humps, but a final conclusion could not be reached.

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Fichiers liés : aa2580-04.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Marc FournierPhilippe RazinOlivier FabbriJean-Paul Breton
• Organismes : Laboratoire de tectonique Environnement, Géo-ingénierie et Développement Laboratoire Chrono-environnement (UMR 6249) Bureau de Recherches Géologiques et Minières
• Publié dans Geoarabia le 02/11/2020

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Résumé : On the basis of field observations in the Huqf area in eastern Oman, Montenat et al. (2003) defined an extensional phase of faulting of Aptian age in the Arabian platform (see also Montenat and Barrier, 2002). We recently revisited the fault exposures of the Wadi Sha'bat al Tawraq from which this conclusion has been drawn (location in Figure 1a). Our observations contradict those of Montenat et al. (2003), and consequently our conclusions are opposite from theirs. Here we review the conflicting observations and discuss the different interpretations.

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Fichiers liés : Fournier_et_HAL_GeoArabia_2005.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2005
• Auteurs : Fabien MalbetJean-Philippe BergerPaulo GarciaPierre KernKarine PerrautMyriam BenistyLaurent JocouEmilie HerwatsJean-Baptiste LebouquinPierre LabeyeEtienne Le CoarerOlivier PreisEric TatulliÉric Thiébaut
• Organismes : Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Centro de Astrofísica da Universidade do Porto Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Centre de Recherche Astrophysique de Lyon

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Résumé : The VITRUV project has the objective to deliver milli-arcsecond spectro-images of the environment of compact sources like young stars, active galaxies and evolved stars to the community. This instrument of the VLTI second generation based on the integrated optics technology is able to combine from 4 to 8 beams from the VLT telescopes. Working primarily in the near infrared, it will provide intermediate to high spectral resolutions and eventually polarization analysis. This paper summarizes the result from the concept study led within the Joint Research Activity advanced instruments of the OPTICON program.

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Fichiers liés : malbet-vitruv.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Benoit BlossierDamir BeciverivPh. BoucaudGregorio HerdoizaJean-Pierre LeroyAlain Le YaouancVincent MorenasOlivier Pene
• Organismes : Laboratoire de Physique Théorique d'Orsay [Orsay] Laboratoire de Physique Théorique d'Orsay [Orsay] Laboratoire de Physique Théorique d'Orsay [Orsay] Dipartimento de Fisica, Università degli studi di Roma II Laboratoire de Physique Théorique d'Orsay [Orsay] Laboratoire de Physique Théorique d'Orsay [Orsay] Laboratoire de Physique Corpusculaire - Clermont-Ferrand Laboratoire de Physique Théorique d'Orsay [Orsay]
• Publié dans Physics Letters B le 02/11/2020

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Résumé : We propose a method to compute the Isgur-Wise form factors tau_1/2(1) and tau_3/2(1) for the decay of B mesons into orbitally excited (P wave) D** charmed mesons on the lattice in the static limit. We also present the result of an exploratory numerical simulation which shows that the signal/noise ratio allows for a more dedicated computation. We find tau_1/2(1)=0.38(5) and tau_3/2(1)= 0.53(8), with yet unknown systematic errors. These preliminary numbers agree fairly well with theoretical expectation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : C. MendibidePhilippe SteyerJean-Pierre Millet
• Organismes : Matériaux, ingénierie et science [Villeurbanne] Matériaux, ingénierie et science [Villeurbanne]
• Publié dans Surface and Coatings Technology le 31/10/2020

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Résumé : Corrosion resistance of nanomultilayered TiN/CrN coatings has been evaluated in saline aqueous neutral solution and compared with monolayered TiN and CrN references. Coatings have been deposited by magnetron sputtering on M2 tool steel, as well as on glass strip, to determine their intrinsic electrochemical behavior. Corrosion resistance afforded by CrN is better than TiN, which is explained by the formation of a thin oxide passive film with favorable semiconductive properties. Nanostratified structure improves the coating density, but the electrochemical behavior is however mainly controlled by the nature of the outer layer, which must be CrN to optimize protection ability.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2005
• Auteurs : Philippe DulbeccoJean-Pierre Allegret
• Organismes : Centre d'Études et de Recherches sur le Développement International

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : David AzriaFrédéric BibeauNicolas BarbierAbderrahim ZouhairClaire LemanskiPhilippe RouanetMarc YchouPierre SenesseMahmut OzsahinAndré PèlegrinJean-Bernard DuboisSimon Thezenas
• Organismes : Département de radiothérapie Immunociblage des Tumeurs et Ingenierie des Anticorps Laboratoire d'anatomo-pathologie Département de radiothérapie Département de radiothérapie Département de Radiothérapie Département de radiothérapie Département de chirugie oncologique Immunociblage des Tumeurs et Ingenierie des Anticorps Département d'oncologie médicale et digestive Département d'oncologie médicale et digestive Département de Radiothérapie Immunociblage des Tumeurs et Ingenierie des Anticorps Département de radiothérapie Unité de Biostatistiques
• Publié dans BMC Cancer le 01/11/2020

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Résumé : BACKGROUND: Epidermal growth factor receptor (EGFR) represents a major target for current radiosensitizing strategies. We wished to ascertain whether a correlation exists between the expression of EGFR and treatment outcome in a group of patients with rectal adenocarcinoma who had undergone preoperative radiotherapy (RT). METHODS: Within a six-year period, 138 patients underwent preoperative radiotherapy and curative surgery for rectal cancer (UICC stages II-III) at our institute. Among them, 77 pretherapeutic tumor biopsies were available for semi-quantitative immunohistochemical investigation evaluating the intensity and the number (extent) of tumor stained cells. Statistical analyses included Cox regression for calculating risk ratios of survival endpoints and logistic regression for determining odds ratios for the development of loco-regional recurrences. RESULTS: Median age was 64 years (range: 30-88). Initial staging showed 75% and 25% stage II and III tumors, respectively. RT consisted of 44-Gy pelvic irradiation in 2-Gy fractions using 18-MV photons. In 25 very low-rectal-cancer patients the primary tumor received a boost dose of up to 16 Gy for a sphincter-preservation approach. Concomitant chemotherapy was used in 17% of the cases. All patients underwent complete total mesorectal resection. Positive staining (EGFR+) was observed in 43 patients (56%). Median follow-up was 36 months (range: 6-86). Locoregional recurrence rates were 7 and 20% for EGFR extent inferior and superior to 25%, respectively. The corresponding locoregional recurrence-free survival rate at two years was 94% (95% confidence interval, CI, 92-98%) and 84% (CI 95%, 58-95%), respectively (P = 0.06). Multivariate analyses showed a significant correlation between the rate of loco-regional recurrence and three parameters: EGFR extent superior to 25% (hazard ratio = 7.18, CI 95%, 1.17-46, P = 0.037), rectal resection with microscopic residue (hazard ratio = 6.92, CI 95%, 1.18-40.41, P = 0.032), and a total dose of 44 Gy (hazard ratio = 5.78, CI 95%, 1.04-32.05, P = 0.045). CONCLUSION: EGFR expression impacts on loco-regional recurrence. Knowledge of expression of EGFR in rectal cancer could contribute to the identification of patients with an increased risk of recurrences, and to the prediction of prognosis.

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Fichiers liés : 1471-2407-5-62.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Jérôme MathieuJean-Pierre RossiPhilippe MoraPatrick LavelleCorinne RoulandGrimaldi Michel
• Organismes : Biogéochimie et écologie des milieux continentaux Biodiversité et fonctionnement du sol Biogéochimie et écologie des milieux continentaux Biogéochimie et écologie des milieux continentaux Biogéochimie et écologie des milieux continentaux
• Publié dans Conservation Biology le 30/10/2020

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