Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2005
• Auteurs : Lise Crevier-BuchmanMieke MoermanJean-Pierre MartensVirginie WoisardPhilippe Dejonckere
• Organismes : LPP - Laboratoire de Phonétique et Phonologie - UMR 7018 Hôpital Européen Georges Pompidou [APHP]

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Michael KüppersIvano BertiniSonia FornasierPedro J. GutiérrezStubbe F. HviidL. JordaHorst Uwe KellerJörg KnollenbergDetlef KoschnyRainer KrammLuisa-Maria LaraHolger SierksNicolas ThomasCesare BarbieriPhilippe LamyHans RickmanRafael RodrigoMichael F. A'HearnF. AngrilliM.E. BaileyP. BartholMaria Antonietta BarucciJean-Loup BertauxJ.A. BurnsGabriele CremoneseW. CurdtM. de CeccoS. DebeiM. FulleF. GliemW.-H. IpEkkehard KührtA. LlebariaJ.J. Lopez MorenoF. MarzariG. NalettoL. SabauA. Sanz AndrésJ.P. SivanG. TondelloK.-P. Wenzel
• Organismes : Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Dipartimento di Astronomia [Padova] Dipartimento di Astronomia [Padova] Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Laboratoire d'Astrophysique de Marseille Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research DLR Institut für Planetenforschung Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Instituto de Astrofísica de Andalucía = Institute of Astrophysics of Andalusia Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research Dipartimento di Astronomia [Padova] Laboratoire d'Astrophysique de Marseille Uppsala Astronomical 0bservatory Instituto de Astrofísica de Andalucía = Institute of Astrophysics of Andalusia Service d'aéronomie
• Publié dans Nature le 29/10/2020

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Résumé : Comets spend most of their life in a low-temperature environment far from the Sun. They are therefore relatively unprocessed and maintain information about the formation conditions of the planetary system, but the structure and composition of their nuclei are poorly understood. Although in situ and remote measurements have derived the global properties of some cometary nuclei, little is known about their interiors. The Deep Impact mission shot a projectile into comet 9P/Tempel 1 in order to investigate its interior. Here we report the water vapour content (1.5 Å~ 1032 water molecules or 4.5 Å~ 106kg) and the cross-section of the dust (330km2 assuming an albedo of 0.1) created by the impact. The corresponding dust/ice mass ratio is probably larger than one, suggesting that comets are `icy dirtballs' rather than `dirty snowballs' as commonly believed. High dust velocities (between 110ms-1 and 300ms-1) imply acceleration in the comet's coma, probably by water molecules sublimated by solar radiation. We did not find evidence of enhanced activity of 9P/Tempel 1 in the days after the impact, suggesting that in general impacts of meteoroids are not the cause of cometary outbursts.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Pierre MahéNobuhisa UedaTatsuya AkutsuJean-Luc PerretJean-Philippe Vert
• Organismes : Centre de Bioinformatique Centre de Bioinformatique
• Publié dans Journal of Chemical Information and Modeling le 27/10/2020

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Résumé : The support vector machine algorithm together with graph kernel functions has recently been introduced to model structure-activity relationships (SAR) of molecules from their 2D structure, without the need for explicit molecular descriptor computation. We propose two extensions to this approach with the double goal to reduce the computational burden associated with the model and to enhance its predictive accuracy: description of the molecules by a Morgan index process and definition of a second-order Markov model for random walks on 2D structures. Experiments on two mutagenicity data sets validate the proposed extensions, making this approach a possible complementary alternative to other modeling strategies.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Pierre-Yves BondiauGrégoire MalandainStéphane ChanaletPierre-Yves MarcyJean-Louis HabrandFrançois FauchonPhilippe PaquisAdel CourdiOlivier CommowickIsabelle RuttenNicholas Ayache
• Organismes : Medical imaging and robotics Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Medical imaging and robotics Analysis and Simulation of Biomedical Images Analysis and Simulation of Biomedical Images Computational Radiology Laboratory [Boston] Vision, Action et Gestion d'informations en Santé Medical imaging and robotics Analysis and Simulation of Biomedical Images
• Publié dans International Journal of Radiation Oncology, Biology, Physics le 31/10/2020

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Résumé : PURPOSE: Brain tumor radiotherapy requires the volume measurements and the localization of several individual brain structures. Any tool that can assist the physician to perform the delineation would then be of great help. Among segmentation methods, those that are atlas-based are appealing because they are able to segment several structures simultaneously, while preserving the anatomy topology. This study aims to evaluate such a method in a clinical context. METHODS AND MATERIALS: The brain atlas is made of two three-dimensional (3D) volumes: the first is an artificial 3D magnetic resonance imaging (MRI); the second consists of the segmented structures in this artificial MRI. The elastic registration of the artificial 3D MRI against a patient 3D MRI dataset yields an elastic transformation that can be applied to the labeled image. The elastic transformation is obtained by minimizing the sum of the square differences of the image intensities and derived from the optical flow principle. This automatic delineation (AD) enables the mapping of the segmented structures onto the patient MRI. Parameters of the AD have been optimized on a set of 20 patients. Results are obtained on a series of 6 patients' MRI. A comprehensive validation of the AD has been conducted on performance of atlas-based segmentation in a clinical context with volume, position, sensitivity, and specificity that are compared by a panel of seven experimented physicians for the brain tumor treatments. RESULTS: Expert interobserver volume variability ranged from 16.70 cm(3) to 41.26 cm(3). For patients, the ratio of minimal to maximal volume ranged from 48% to 70%. Median volume varied from 19.47 cm(3) to 27.66 cm(3) and volume of the brainstem calculated by AD varied from 17.75 cm(3) to 24.54 cm(3). Medians of experts ranged, respectively, for sensitivity and specificity, from 0.75 to 0.98 and from 0.85 to 0.99. Median of AD were, respectively, 0.77 and 0.97. Mean of experts ranged, respectively, from 0.78 to 0.97 and from 0.86 to 0.99. Mean of AD were, respectively, 0.76 and 0.97. CONCLUSIONS: Results demonstrate that the method is repeatable, provides a good trade-off between accuracy and robustness, and leads to reproducible segmentation and labeling. These results can be improved by enriching the atlas with the rough information of tumor or by using different laws of deformation for the different structures. Qualitative results also suggest that this method can be used for automatic segmentation of other organs such as neck, thorax, abdomen, pelvis, and limbs.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : David BessonOlivier ParizeJean-Loup RubinoJean-Pierre AguilarMarie-Pierre AubryBernard BeaudoinWilliam A. BerggrenGeorges ClauzonPhilippe CrumeyrolleYann DexcotéNicolas FietSilvia IaccarinoGonzalo Jiménez-MorenoCécile Laporte-GalaaJacques MichauxKatharina von SalisJean-Pierre SucJean-Yves ReynaudRoland Wernli
• Organismes : Centre de Géotechnique et d'exploitation du sous sol Centre de Géotechnique et d'exploitation du sous sol Total, CST JF–TG/ISS Institut des Sciences de l'Evolution de Montpellier Centre de Géotechnique et d'exploitation du sous sol Total, CST JF–TG/ISS Centre de Géotechnique et d'exploitation du sous sol PaleoEnvironnements et PaleobioSphere Total, CST JF–TG/ISS Institut des Sciences de l'Evolution de Montpellier PaleoEnvironnements et PaleobioSphere
• Publié dans Comptes Rendus. Géoscience le 29/07/2021

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Résumé : An integrated study combining facies analysis, multiple group biostratigraphy, identification of depositional sequences and mapping has been conducted on the Miocene Molasse Basin of the external Alps (southeastern France). The filling of the basin is described as resulting from a succession of fluvial incisions subsequently filled during marine transgressions. The major incision is dated as Latest Burdigalian and the major transgression as Langhian. This revised interpretation of the Miocene physiographic evolution of the Molasse Basin implies a re-examination of previous stratigraphic correlations within the basin

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Philippe PonelRussell CoopePierre AntoineNicole Limondin-LozouetChantal LeroyerAndré-Valentin MunautJean-François PastreFrédéric Guiter
• Organismes : Institut Méditerranéen d'Ecologie et de Paléoécologie Royal Holloway [University of London] Laboratoire de géographie physique : Environnements Quaternaires et Actuels Laboratoire de géographie physique : Environnements Quaternaires et Actuels Ministère de la Culture et de la Communication Centre National de la Préhistoire Université Catholique de Louvain = Catholic University of Louvain Laboratoire de géographie physique : Environnements Quaternaires et Actuels Institut Méditerranéen d'Ecologie et de Paléoécologie
• Publié dans Quaternary Science Reviews le 27/10/2020

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2005
• Auteurs : Jean-Luc BergerDominique BlancardClaudine CharpentierMorvan CoarerPhilippe DarrietLaurence GuerinRémi Guérin-SchneiderAhmed LebrihiValérie LempereurOdile MeurguesChristine MouilletPierre SaurisBéatrice Vincent
• Organismes : Institut Français de la Vigne et du Vin [Siège] Unité Mixte de Recherche en Santé Végétale (INRA/ENITA) Institut Universitaire de la Vigne et du Vin "Jules Guyot" Institut Français de la Vigne et du Vin [Siège] Oenologie Institut Français de la Vigne et du Vin [Siège] Institut Français de la Vigne et du Vin [Siège] École nationale supérieure agronomique de Toulouse Institut Français de la Vigne et du Vin [Siège] Bureau interprofessionnel des vins de Bourgogne Office National Interprofessionnel des Vins Unité Mixte de Recherche en Santé Végétale (INRA/ENITA) Institut Français de la Vigne et du Vin [Siège]

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Jean-Pierre HamardPhilippe Ballon
• Organismes : Écosystèmes forestiers Écosystèmes forestiers
• Publié dans Forêt Entreprise le 26/10/2020

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Résumé : Un observatoire des dégâts de cervidés en forêt a été réalisé durant l'hiver 1999/2000 à l'échelle de cinq départements (Landes, Oise, Sarthe, Tarn et Vosges). Cette étude dresse un état de la réalité des dégâts et en évalue l'impact sur la sylviculture. D'une manière générale, en sylviculture régulière, la surface forestière sensible aux dégâts de cervidés demeure faible (1 à 4%). L'origine des peuplements, la nature des essences, l'importance des populations de cervidés et leur gestion jouent un rôle déterminant dans l'acuité des dommages. Ce sont l'Oise et les Vosges qui subissent les situations les plus préoccupantes.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2005
• Auteurs : Philippe Bordes
• Organismes : Art, images, sociétés

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Anne BohinFranck BouchartColette RichetOsarath KolYves LeroyPhilippe TimmermanGuillemette HuetJean-Pierre BohinJean-Pierre Zanetta
• Organismes : Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Mucines Epitheliales : du Gene a la Fonction Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Mucines Epitheliales : du Gene a la Fonction Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
• Publié dans Analytical Biochemistry le 26/10/2020

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Résumé : In previous papers (Pons et al., Anal. Biochem. 284 (2000) 201-216; Pons et al., J. Lipid Res. 43 (2002) 794-804), we reported that the GC/MS identification and quantification of almost all constituents of glycolipids could be obtained on the same sample in a single GC/MS analysis as heptafluorobutyrate derivatives of the products liberated using acid-catalysed methanolysis. The same type of data could be obtained on glycoproteins and proteoglycans (Pons et al., Biochemistry 42 (2003) 8342-8353). These experiments were performed on material from higher organisms and no evidence was provided that bacteria-specific constituents could be also identified and quantified. This manuscript reports that the GC/MS analysis of compounds liberated by acid-catalysed methanolysis as heptafluorobutyrate derivatives allows the simultaneous qualitative and quantitative determinations of pentoses, deoxyhexoses, hexoses, hexosamines, uronic acids, Kdo, Mur, heptose, Kdn and neuraminic acid and of most fatty acids (including hydroxylated fatty acids). This approach provides a way for obtaining fingerprints of bacterial constituents and quantification of the overall effect of gene inactivation or of culture conditions.

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