Philippe JEAN-PIERRE

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 31/07/2005
• Auteurs : P. FerrandoA. GoldwurmPhilippe LaurentJ. MartignacF. PinsardY. RioJean-Pierre RoquesO. CitterioG. PareschiG. TagliaferriF. FioreG. MalagutiU. BrielG. HasingerL. Strueder
• Organismes : APC - Astrophysique des Hautes Energies AstroParticule et Cosmologie Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée AstroParticule et Cosmologie Département d'Astrophysique, de physique des Particules, de physique Nucléaire et de l'Instrumentation Associée
• Publié dans Proceedings of SPIE, the International Society for Optical Engineering le 09/05/2016

---

Résumé : SIMBOL-X is a hard X-ray mission, operating in the ~ 0.5-70 keV range, which is proposed by a consortium of European laboratories in response to the 2004 call for ideas of CNES for a scientific mission to be flown on a formation flying demonstrator. Relying on two spacecrafts in a formation flying configuration, SIMBOL-X uses for the first time a ~ 30 m focal length X-ray mirror to focus X-rays with energy above 10 keV, resulting in a two orders of magnitude improvement in angular resolution and sensitivity in the hard X-ray range with respect to non focusing techniques. The SIMBOL-X revolutionary instrumental capabilities will allow to elucidate outstanding questions in high energy astrophysics, related in particular to the physics of accretion onto compact objects, to the acceleration of particles to the highest energies, and to the nature of the Cosmic X-Ray background. The mission, which has gone through a thorough assessment study performed by CNES, is expected to start a competitive phase A in autumn 2005, leading to a flight decision at the end of 2006, for a launch in 2012. The mission science objectives, the current status of the instrumentation and mission design, as well as potential trade-offs are presented in this paper.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 31/07/2005
• Auteurs : Mathieu PuechFanny ChemlaPhilippe LaportePascal JagourelÉric GendronFrançois HammerFrançois AssématJean-Marc ConanThierry FuscoArnaud LiotardFrédéric Zamkotsian
• Organismes : Galaxies, Etoiles, Physique, Instrumentation Physique des Galaxies et Cosmologie Pôle instrumental Galaxies, Etoiles, Physique, Instrumentation Physique des Galaxies et Cosmologie Pôle instrumental Galaxies, Etoiles, Physique, Instrumentation Physique des Galaxies et Cosmologie Pôle instrumental Galaxies, Etoiles, Physique, Instrumentation Physique des Galaxies et Cosmologie Pôle instrumental Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA Galaxies, Etoiles, Physique, Instrumentation Physique des Galaxies et Cosmologie Pôle instrumental Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Astronomie du LESIA

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 07/07/2005
• Auteurs : Uwe MaskosB. E. MollesStéphane PonsM. BessonBruno GuiardJean-Philippe GuillouxAugust EvrardPierre CazalaAnne CormierM. Mameli-EngvallNicolas DufourIsabelle Cloëz-TayaraniAlexis-Pierre BemelmansJacques MalletAlain M. GardierV. DavidPierre FaureSylvie GranonJean-Pierre Changeux
• Organismes : Récepteurs et Cognition Récepteurs et Cognition Récepteurs et Cognition Récepteurs et Cognition Sérotonine et neuropharmacologie Sérotonine et neuropharmacologie Sérotonine et neuropharmacologie Récepteurs et Cognition Neurosciences cognitives Récepteurs et Cognition Récepteurs et Cognition Génétique moléculaire de la neurotransmission et des processus neurodégénératifs Récepteurs et Cognition Génétique moléculaire de la neurotransmission et des processus neurodégénératifs Génétique moléculaire de la neurotransmission et des processus neurodégénératifs Sérotonine et neuropharmacologie Neurosciences cognitives Récepteurs et Cognition Récepteurs et Cognition Récepteurs et Cognition
• Publié dans Nature le 29/10/2020

---

Résumé : Worldwide, 100 million people are expected to die this century from the consequences of nicotine addiction, but nicotine is also known to enhance cognitive performance. Identifying the molecular mechanisms involved in nicotine reinforcement and cognition is a priority and requires the development of new in vivo experimental paradigms. The ventral tegmental area (VTA) of the midbrain is thought to mediate the reinforcement properties of many drugs of abuse. Here we specifically re-expressed the beta2-subunit of the nicotinic acetylcholine receptor (nAChR) by stereotaxically injecting a lentiviral vector into the VTA of mice carrying beta2-subunit deletions. We demonstrate the efficient re-expression of electrophysiologically responsive, ligand-binding nicotinic acetylcholine receptors in dopamine-containing neurons of the VTA, together with the recovery of nicotine-elicited dopamine release and nicotine self-administration. We also quantified exploratory behaviours of the mice, and showed that beta2-subunit re-expression restored slow exploratory behaviour (a measure of cognitive function) to wild-type levels, but did not affect fast navigation behaviour. We thus demonstrate the sufficient role of the VTA in both nicotine reinforcement and endogenous cholinergic regulation of cognitive functions.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2005
• Auteurs : Emmanuel GayJean Philippe VuillezOlivier PalombiPierre Yves BrardPierre BessouJean Guy Passagia
• Organismes : Département de neurochirurgie Service de médecine nucléaire et biophysique Département de neurochirurgie Service de médecine nucléaire et biophysique Département de neuro-radiologie Département de neurochirurgie
• Publié dans Neurosurgery le 01/11/2020

---

Résumé : OBJECTIVE: Scintigraphy with a radiolabeled somatostatin analog ((111)In-diethylenetriaminepenta-acetic acid octreotide) detects the somatostatin receptors that are found in vitro in all meningiomas. Previous studies have proved the benefit of radioimmunoguided surgery, with a hand-held gamma probe, for the assessment and removal of neuroendocrine tumors. We conducted a study to determine whether intraoperative radiodetection of somatostatin receptors is feasible and could increase the probability of complete meningioma resection, especially for bone-invasive en plaque meningiomas, which are difficult to control surgically. METHODS: Eighteen patients with en plaque sphenoid wing and cranial convexity meningiomas were studied by preoperative and postoperative somatostatin receptor scintigraphy. In 10 of them, intraoperative radiodetection with a hand-held gamma probe was performed 24 hours after the intravenous administration of (111)In-diethylenetriaminepenta-acetic acid octreotide. This procedure was combined with a computer-aided navigation system. RESULTS: All preoperative scintigrams were positive. Intraoperative gamma probe detection was achieved for the invaded bone, dura, and periorbit of sphenoid wing meningiomas. The average tumor/nontumor count ratio was 2:1, with a maximum of 12:1, thus allowing precise detection capable of defining the tumor margins. In three cases of sphenoid wing meningiomas, postoperative scintigrams were helpful for the determination of recurrences that magnetic resonance imaging failed to detect. CONCLUSION: These preliminary data show that intraoperative radiodetection of somatostatin receptors with a hand-held gamma probe is feasible and may be helpful to guide the surgical removal of bone-invasive en plaque meningiomas. Preoperative and postoperative scintigraphy may be useful for the management and follow-up of patients with these tumors.

---

Fichiers liés : Patient_table_1_REVISION.pdf figure_2.pdf inserm-00391007_edited.pdf Intraoperative_and_Postoperative_Gamma_Detection_of_REVISION.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2005
• Auteurs : Thierry ThevenotClaire VanlemmensVincent Di MartinoMarie-Claude BeckerPierre-Olivier DenueBernadette KantelipSolange Bresson-HadniBruno HeydGeorges MantionJean-Philippe Miguet
• Organismes : Service d'Hépatologie [CHRU Besançon] Service d'Hépatologie [CHRU Besançon] Service d'Hépatologie [CHRU Besançon] Service d'Hépatologie [CHRU Besançon] Service de Chirurgie Digestive [CHRU Besançon] Service d'Hépatologie [CHRU Besançon] Service de Chirurgie Digestive [CHRU Besançon] Service de Chirurgie Digestive [CHRU Besançon] Service d'Hépatologie [CHRU Besançon]
• Publié dans Liver Transplantation le 27/10/2020

---

Résumé : Liver involvement in hereditary hemorrhagic telangiectasia may lead to high-output cardiac failure. Few data have been reported on orthotopic liver transplantation (OLT) for these patients. In this paper, we describe two patients treated by OLT as a salvage procedure for cardiac failure, and we review literature on this subject. Our two patients resumed normal cardiac function after OLT. This procedure appears to be a promising therapy with good long-term results despite dissection difficulties encountered due to the collateral arterial network reorganization.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2005
• Auteurs : Thomas DecaensFrançoise Roudot-ThoravalSolange Bresson-HadniCarole MeyerJean GugenheimFrancois DurandPierre-Henri BernardOlivier BoillotKarim BoudjemaYvon CalmusJean HardwigsenChristian DucerfGeorges-Philippe PageauxSebastien DharancyOlivier ChazouilleresDaniel DhumeauxDaniel CherquiChristophe DuvouxFrançoise Roudot‐thoravalSolange Bresson-HadniPierre‐henri Bernard
• Organismes : CHU Henri Mondor [Créteil] Pôle Recherche Clinique-Santé Publique [Mondor] Service d'Hépatologie [CHRU Besançon]
• Publié dans Liver Transplantation le 27/10/2020

---

Résumé : The actual impact of transarterial chemoembolization before liver transplantation (LT) for hepatocellular carcinoma (HCC) on patient survival and HCC recurrence is not known. Between 1985 and 1998, 479 patients with HCC in 14 French centers were evaluated for LT. Among these 479 patients, this case-control study included 100 patients who received transarterial chemoembolization before LT (TACE group) and 100 control patients who did not receive chemoembolization (no-TACE group). Patients and controls were matched for the pre-LT tumor characteristics, the period of transplantation, the time spent on the waiting list, and pre- and posttransplantation treatments. Kaplan-Meier estimates were calculated 5 years after LT and were compared with the log-rank test. The mean waiting time before LT was 4.2 +/- 3.2 months in the TACE group and 4.3 +/- 4.4 months in the no-TACE group. The median number of TACE procedures was 1 (range: 1-12). Demographic data, median alpha-fetoprotein level (21.6 ng/mL and 22.0 ng/mL, respectively), and pre- and post-LT morphologic characteristics of the tumors did not differ in the TACE and no-TACE groups. Overall 5-year survival was 59.4% with TACE and 59.3% without TACE (ns). Survival rates did not differ significantly between the two groups with respect to the time on the waiting list, the tumor diameter, or the type of TACE (selective or nonselective). In the TACE group, 30 patients had tumor necrosis > or =80% on the liver explant with a 5-year survival rate of 63.2%, compared with 54.2% among their matched controls (P = 0.9). In conclusion, with a mean waiting period of 4.2 months and 1 TACE procedure, pre-LT TACE does not influence post-LT overall survival and disease-free survival.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2005
• Auteurs : Stéphane LambrechtPhilippe MichelJean-Pierre Vidal
• Organismes : Center for Operations Research and Econometrics CORE Groupe de Recherches Modélisation Appliquée à la Recherche en Sciences Sociales Université de Lille, Sciences Humaines et Sociales Groupement de Recherche en Économie Quantitative d'Aix-Marseille European Central Bank
• Publié dans European Economic Review le 24/10/2020

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/07/2005
• Auteurs : Isabelle Le BlancPierre-Philippe LuyetVéronique PonsCharles FergusonNeil EmansAnne PetiotNathalie MayranNicolas DemaurexJulien FauréRémy SadoulRobert G. PartonJean Gruenberg
• Organismes : Biochemistry Department Department of Molecular & Cell Biology [Berkeley] Biochemistry Department Biochemistry Department Institute for Molecular Bioscience Institut Pasteur Korea - Institut Pasteur de Corée Biochemistry Department Glycobiologie et signalisation cellulaire Biochemistry Department Institute of Experimental Pathology Department of Physiology Neurodegenerescence et Plasticite Neurodegenerescence et Plasticite Institute for Molecular Bioscience Biochemistry Department
• Publié dans Nature Cell Biology le 31/10/2020

---

Résumé : During viral infection, fusion of the viral envelope with endosomal membranes and nucleocapsid release were thought to be concomitant events. We show here that for the vesicular stomatitis virus they occur sequentially, at two successive steps of the endocytic pathway. Fusion already occurs in transport intermediates between early and late endosomes, presumably releasing the nucleocapsid within the lumen of intra-endosomal vesicles, where it remains hidden. Transport to late endosomes is then required for the nucleocapsid to be delivered to the cytoplasm. This last step, which initiates infection, depends on the late endosomal lipid lysobisphosphatidic acid (LBPA) and its putative effector Alix/AIP1, and is regulated by phosphatidylinositol-3-phosphate (PtdIns3P) signalling via the PtdIns3P-binding protein Snx16. We conclude that the nucleocapsid is exported into the cytoplasm after the back-fusion of internal vesicles with the limiting membrane of late endosomes, and that this process is controlled by the phospholipids LBPA and PtdIns3P and their effectors.

---

Fichiers liés : inserm-00381829_edited.pdf Le_Blanc-Luyet.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 24/06/2005
• Auteurs : Pierre-Yves LozachLaura BurleighIsabelle StaropoliErika Navarro-SanchezJulie HarriagueJean-Louis VirelizierFelix A. ReyPhilippe DesprèsFernando Arenzana-SeisdedosAli Amara
• Organismes : Immunologie Virale Virologie moléculaire et structurale Immunologie Virale Immunologie Virale Interactions Moléculaires Flavivirus-Hôtes Immunologie Virale Immunologie Virale Virologie moléculaire et structurale Interactions Moléculaires Flavivirus-Hôtes Immunologie Virale Immunologie Virale
• Publié dans Journal of Biological Chemistry le 02/11/2020

---

Résumé : Dengue virus ( DV) is a mosquito-borne flavivirus that causes hemorrhagic fever in humans. In the natural infection, DV is introduced into human skin by an infected mosquito vector where it is believed to target immature dendritic cells (DCs) and Langerhans cells (LCs). We found that DV productively infects DCs but not LCs. We show here that the interactions between DV E protein, the sole mannosylated glycoprotein present on DV particles, and the C-type lectin dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) are essential for DV infection of DCs. Binding of mannosylated N-glycans on DV E protein to DC-SIGN triggers a rapid and efficient internalization of the viral glycoprotein. However, we observed that endocytosis-defective DC-SIGN molecules allow efficient DV replication, indicating that DC-SIGN endocytosis is dispensable for the internalization step in DV entry. Together, these results argue in favor of a mechanism by which DC-SIGN enhances DV entry and infection in cis. We propose that DC-SIGN concentrates mosquito-derived DV particles at the cell surface to allow efficient interaction with an as yet unidentified entry factor that is ultimately responsible for DV internalization and pH-dependent fusion into DCs.

---

Fichiers liés : 2005_Lozach_Journal of Biological Chemistry_1.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 10/06/2005
• Auteurs : Jean-Claude DesportFrédéric TornyM. LacostePierre-Marie PreuxPhilippe Couratier
• Organismes : Neuroépidémiologie Tropicale et Comparée Service d'Hépato-gastro-entérologie et Nutrition [CHU Dupuytren 1, Limoges] Service de Neurologie [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Laboratoire de Biostatistique et d'Informatique Médicale Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Service de Neurologie [CHU Limoges]

---

Source