Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 16/04/2024
• Auteurs : Linda HumbertEmmanuelle Proust-LemoineSylvain DubucquoiElisabeth Helen KempPascale Saugier-VeberNicole FabienIsabelle Raymond-TopCatherine Cardot-BautersJean-Claude CarelMaryse CartignyOlivier ChabrePhilippe ChansonBrigitte DelemerChristine Do CaoLaurence GuignatJean-Emmannuel KahnVeronique KerlanHervé LefebvreAgnès LinglartRoberto MalloneRachel ReynaudBoualem SendidPierre-François SouchonPhilippe TouraineJean-Louis WémeauMarie-Christine Vantyghem
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Lille Inflammation Research International Center - U 995 Université de Lille University of Sheffield [Sheffield] Université de Rouen Normandie Hospices Civils de Lyon Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] UFR Médecine [Santé] - Université Paris Cité Centre Hospitalier Régional Universitaire [CHU Lille] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Physiologie et physiopathologie endocriniennes AP-HP. Université Paris Saclay Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Université Paris-Saclay AP-HP Hôpital universitaire Robert-Debré [Paris] Hôpital Claude Huriez [Lille] Hôpital Cochin [AP-HP] Lille Inflammation Research International Center - U 995 Université de Lille Centre Hospitalier Régional Universitaire de Brest Université de Rouen Normandie Neuroendocrine, Endocrine and Germinal Differentiation Communication Service d'endocrinologie, diabétologie et maladies métaboliques [Rouen] Physiologie et physiopathologie endocriniennes Université Paris-Saclay Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Institut Cochin Hôpital de la Timone [CHU - APHM] Aix Marseille Université Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Hôpital universitaire Robert Debré [Reims] Sorbonne Université Centre Hospitalier Régional Universitaire [CHU Lille] Recherche translationnelle sur le diabète - U 1190
• Publié dans Journal of Clinical Endocrinology and Metabolism le 01/11/2020

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Résumé : Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy syndrome is a rare disease caused by biallelic mutations of the AIRE gene, usually presenting with the triad hypoparathyroidism-adrenal failure-chronic mucocutaneous candidiasis (CMC) and nonendocrine manifestations. The aim of this study was to determine the molecular profile of the AIRE gene, the prevalence of rare manifestations, and to characterize immunological disturbances in a French cohort.

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Fichiers liés : dgae211.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 16/04/2024
• Auteurs : Pierre GasnierMaxime GallardoRamzy RammouzNicolas GarraudLouis AraouzosAlexandra GarraudJean-Philippe Gros
• Organismes : Département Systèmes SERMA INGENIERIE Département Systèmes Département Systèmes Enerbee Technology F2A Group, F-38000 Grenoble, France Enerbee Technology F2A Group, F-38000 Grenoble, France Département Systèmes

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Résumé : In this work, we present the next generation of magnetoelectric energy harvesters developed by Enerbee Technology, and the associated power management circuit that was developed by CEA-Leti. Enerbee Technology develops a self-sufficient and connected product embedded with sensors for the regulation of indoor air quality in non-residential buildings, providing a low maintenance solution to increase the health and well-being of both the structure and the occupants, for the whole lifetime of the infrastructure. In this new generation of energy harvester, the piezoelectric part of the energy harvester has been optimized to better extract charges from the material. Therefore, a 3.4× size reduction is achieved while maintaining the same harvested energy. On the electronic side, we report a power management circuit based on a low-power implementation of a non-linear extraction technique by controlling a Flyback converter with a microcontroller unit: energy extraction occurs at the maximum voltage of the magnetoelectric harvester, allowing more power to be harvested compared to standard circuits. Compared with the standard energy harvesting interface, a power gain up to 1.75 is measured at a frequency of 47 Hz, and a Flyback efficiency up to 80% is reported for a total power of 0.5 mW.

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Fichiers liés : SSI_PowerBee _final.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2024
• Auteurs : Antoine BachelardQuentin Le HingratValentine-Marie FerréMinh LêGilles PeytavinFlorence DamondCharlotte CharpentierGuillemette Fremont GoudotJeanne Goupil de BouilleSylvie LarivenPierre DelobelYazdan YazdanpanahDiane DescampsSophie MatheronJade GhosnVictor AppayBrigitte AutranAmel BesseghirSandrine Couffin-CardierguesChloé BirkléFrançoise Brun-VezinetGeneviève ChêneRémi CheynierFidéline CollinSerge EholieDidier EkouvieCatherine FaguardDelphine LebrasseurJulie LongobardiLucie MarchandMichaela Muller-TrutwinAlexandra OzanneVentzislava Petrov-SanchezCéline RoyAsier Saez-CirionFrançois SimonLinda WittkopMarie Caroline MeyohasKarine LacombeDominique SalmonAgathe RamiGilles PialouxRoland TubianaPierrre de TruchisMarie-Aude Khuong-JossesOuda DerradjiDidier TroisvalletJulie TimsitAnne-Sophie LascauxVincent JeantilsOlivier BouchaudOlivier PateyPauline Caraux-PazCécile GoujardLaurence GérardEmmanuel MortierEric FroguelYves WelkerVincent DaneluzziPhilippe GenetAnnie LeprêtreDavid ZucmanGilles ForceAnne Coutellier-SimonJean DeleuzeLaurence WeissValérie GarraitHélène Masson ColinLaurent BlumPr Jean-Daniel LelièvreAnne DulioustVéronique PerroneChristophe BillyCécile WinterIsabelle AupérinIram La TorreJean-Michel MolinaPatrick BrunetSylvia LamyAlain DevidasAmélie ChabrolElisabeth RouveixSerge KernbaumClaudine DuvivierMarie-Anne BouldouyreLoïc BodardPatrick ImbertChristophe RappFrançois BouéAgnès UludagFabrice ChaixOlivia SonOlivier BouchaudJean-Paul ViardXavier DuvalAlix Greder BelanValérie GrégoireGenviève Beck-WirthFrançois RaffiChristine DrobacheffCatherine ChirouzeThierry AllègreRenaud VerdonIsabelle Poizot-MartinCorinne DanielMoise MachadoAnne-Lise LecapitainePr Bruno MarchouLouis BernardYasmine DebabPascale LeclercqJoelle JulienJacques MoreauIsabelle RavauxCédric ArvieuxChristophe MichaudDjamila MakhloufiGwenael LemoalPhilippe ArsacThierry PrazuckAlain LafeuilladeBenoit MarthaPhilippe PerréFaiza AjanaPhilippe MorlatElisabeth BrottierMichel DuponDidier NeauJean-Luc PellegrinIsabelle RaymondNathalie MontagneThierry MayHeidi WilleYoussef DouadiJacques ReynesJean-Louis SchmitChrisitne RougerJean-Luc BergerYves PoinsignonChristiane JacometLionel PirothEric RosenthalDaniel GaripuyMartin MichaudAgnes RichéFrançois Prevoteau Du ClaryAlica NaqviJacques GaillatDavid ReyFrançois AbinoPatrick MerciéPhilippe MorlatPierre-Marie RogerEmmanuelle AïssiJean-Marie ChennebaultDominique LinéNarimamy RandrianasoloCatherine MerlePatricia GranetLaurence CaunègreLaurent CotteLaurent BoileauJean-Batiste EuzenPascale PerfezouNicolas LefebvreJean-Philippe TalarminCatherine ChirouzeSimona PavelBénédicte PonceauJulien SaisonAlbert SottoDidier LaureillardAnne VandendriesscheIuliana DarasteanuChloé BirkléSandrine Couffin-CardierguesDelphine LebrasseurLucie MarchandManal MecheriVentzislava Petrov-SanchezTounes SaidiAmi SangaréAmel BesseghirNathalie Chaghil-BoissièreGeneviève ChêneFidéline CollinValérie ConteMohamed DembeléCatherine FaguardYoussra KhalilJulie LongobardiAlexandra OzanneMaxime PallierLoretxu PinogesCéline RoyLinda WittkopSolaya ChalalLynda OualitLeia BecamSophie CirscotaCarine LascouxLydia LegerMarie LegoffIsabelle PellegrinFrançoise Brun-VezinetLeen YoussefRémi CheynierFrançoise Brun-VézinetBrigitte AutranRémi CheynierGianfranco PancinoAnne HosmalinVincent VieillardVictor AppayFrançoise Brun-VézinetAsier Saez-Cirion
• Organismes : Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Centre Hospitalier Intercommunal André Grégoire [Montreuil] AP-HP - Hôpitaux Universitaires Paris Seine-Saint-Denis Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Institut Toulousain des Maladies Infectieuses et Inflammatoires Service Maladies infectieuses et tropicales [CHU Toulouse] Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution Groupe Hospitalier des Hôpitaux Universitaires Paris Nord Val de Seine [Paris] Infection, Anti-microbiens, Modélisation, Evolution
• Publié dans Clinical Infectious Diseases le 30/10/2020

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Résumé : Abstract We evaluated Ibalizumab (IBA)-containing standardized optimized salvage regimen (with or without a 4-week foscarnet induction) in individuals harboring multidrug-resistant human immunodeficiency virus type 2 (HIV-2). Nine were included; 2 achieved virological suppression after foscarnet induction with a sustained suppression at Week 24 after IBA initiation, and an additional individual at Week 24 after Ibalizumab initiation.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 14/04/2024
• Auteurs : Laurence DelvilleJean-François LéonMélina MacouinYann Philippe TastevinMayoro GueyeArnaud ProiettiLaure LaffontSonia RousseMaria Dias-AlvesFrançois DemoryPierre RochettePedro Henrique da Silva ChibaneAndrea Teixera UstraLoïc. Drigo
• Organismes : Laboratoire d'aérologie Laboratoire d'aérologie Géosciences Environnement Toulouse Unité Mixte Internationale "Environnement Santé Sociétés" Unité Mixte Internationale "Environnement Santé Sociétés" Centre de microcaractérisation Raimond Castaing Géosciences Environnement Toulouse Géosciences Environnement Toulouse Laboratoire d'aérologie Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Insituto de Astronomia, Geofísica e Ciências Atmosféricas, IAG-USP Insituto de Astronomia, Geofísica e Ciências Atmosféricas, IAG-USP Géosciences Environnement Toulouse

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Résumé : Atmospheric aerosols in urban areas are the result of a complex mixture of different anthropogenic sources. The chemical and granulometric profile of urban aerosols varies according to the level of economic and technological development of cities around the world. In particular, road traffic emits carbon compounds (organic and elemental) and metal oxides through combustion, braking and tyre abrasion. Our study focuses on the respective particle size distributions of the carbon and iron oxide fractions using magnetic investigations.We investigated the size distribution of anthropogenic tracers of particulate matter (PM), particulate total carbon (TC) concentration, and saturation isothermal remanent magnetization (SIRM) in two urban settings in France (Toulouse) and Senegal (Sebikotane). Using a cascade impactor, particles were segregated into 5 fractions spanning from PM10 to PM0.01. Particle mass concentration within each size range was determined via gravimetric methods, particulate carbon concentrations were assessed using thermo-optical techniques, and magnetic signals were measured through isothermal induced magnetization acquisitions.Our results showed high concentrations of particulate mass in the coarse fraction (particles larger than 1 µm). The coarse fraction showed a significantly higher magnetic signal than for finer fractions, accounting for 73% in France and 80% in Senegal of the total SIRM. In the ultrafine fraction (<0.2 µm), we noted significantly higher concentrations of TC than for other fractions, representing 41% in France and 36% in Senegal of the total particulate carbon concentration.Electron microscope observations revealed the presence of iron oxide particles in the <0.5 µm fraction however associated with a weak SIRM. Such iron particles may be produced by combustion or abrasion while we suspect that emissions by abrasion process produce larger particles.

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• Type de publi. : Article dans une revue
• Date de publi. : 10/04/2024
• Auteurs : Annefleur LangedijkBram VranckenRobert Jan LebbinkDeidre WilkinsElizabeth KellyEugenio BaraldiAbiel Homero Mascareñas de los SantosDaria DanilenkoEun Hwa ChoiMaría Angélica PalominoHsin ChiChristian KellerRobert CohenJesse PapenburgJeffrey PernicaAnne GreenoughPeter RichmondFederico Martinón-TorresTerho HeikkinenRenato SteinMitsuaki HosoyaMarta NunesCharl VerweyAnouk EversLeyla Kragten-TabatabaieMarc A SuchardSergei Kosakovsky PondChiara PolettoVittoria ColizzaPhilippe LemeyLouis BontElena PrianteKseniya KomissarovaKi Wook YunPascale ClementMonica BauckAtul GuptaUshma WadiaIrene Rivero-CalleMagalia LumertzKoichi HasimotoShabir Madhi
• Organismes : Wilhelmina Children’s Hospital Spatial Epidemiology Lab University Medical Center [Utrecht] AstraZeneca, Gaithersburg AstraZeneca, Gaithersburg Università degli Studi di Padova = University of Padua ReSViNET Foundation Jose Eluterio Gonzalez Hospital Universitario Smorodintsev Research Institute of Influenza [Saint-Petersbourg, Russia] Seoul National University [Seoul] Universidad de Chile = University of Chile [Santiago] Shandong Agricultural University Fujian Agriculture and Forestry University Fujian Academy of Agricultural Sciences University Hospital Giessen and Marburg = Universitätsklinikum Gießen und Marburg Institut Mondor de Recherche Biomédicale Groupe de Pathologie Infectieuse Pédiatrique [Paris] Centre Hospitalier Intercommunal de Créteil Association Clinique et Thérapeutique Infantile du Val de Marne Association Française de Pédiatrie Ambulatoire McGill University = Université McGill [Montréal, Canada] McMaster University [Hamilton, Ontario] King's College Hospital Trinity College Dublin Hospital Clínico Universitario de Santiago University of Turku School of Medicine Fukushima Medical University Santé publique, épidémiologie et écologie évolutive des maladies infectieuses [CIRI] Hospices Civils de Lyon Center of Excellence in Respiratory Pathogens University of the Witwatersrand [Johannesburg] University Medical Center [Utrecht] ReSViNET Foundation University of California [Los Angeles] Institute for Genomics and Evolutionary Medicine, Temple University Università degli Studi di Padova = University of Padua Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique University of Washington [Seattle] Rega Institute for Medical Research [Leuven] University Medical Center [Utrecht] Università degli Studi di Padova = University of Padua Smorodintsev Research Institute of Influenza [Saint-Petersbourg, Russia] Seoul National University [Seoul] Universidad de Chile = University of Chile [Santiago] University Hospital Giessen and Marburg = Universitätsklinikum Gießen und Marburg King‘s College London The University of Western Australia Hospital Clínico Universitario de Santiago Pontifícia Universidade Católica do Rio Grande do Sul = Pontifical Catholic University of Rio Grande do Sul [Brazil] Fukushima Medical University School of Medicine University of the Witwatersrand [Johannesburg]
• Publié dans Nature Communications le 23/10/2020

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Résumé : Abstract Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infection in young children and the second leading cause of infant death worldwide. While global circulation has been extensively studied for respiratory viruses such as seasonal influenza, and more recently also in great detail for SARS-CoV-2, a lack of global multi-annual sampling of complete RSV genomes limits our understanding of RSV molecular epidemiology. Here, we capitalise on the genomic surveillance by the INFORM-RSV study and apply phylodynamic approaches to uncover how selection and neutral epidemiological processes shape RSV diversity. Using complete viral genome sequences, we show similar patterns of site-specific diversifying selection among RSVA and RSVB and recover the imprint of non-neutral epidemic processes on their genealogies. Using a phylogeographic approach, we provide evidence for air travel governing the global patterns of RSVA and RSVB spread, which results in a considerable degree of phylogenetic mixing across countries. Our findings highlight the potential of systematic global RSV genomic surveillance for transforming our understanding of global RSV spread.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/04/2024
• Auteurs : David R ZilkeyJean-Philippe JennyAlexandre BaudPierre FrancusDermot AntoniadesIrene Gregory-Eaves
• Organismes : McGill University = Université McGill [Montréal, Canada] Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques McGill University = Université McGill [Montréal, Canada] Institut National de la Recherche Scientifique [Québec] McGill University = Université McGill [Montréal, Canada]

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Résumé : Understanding how lake ecosystems respond to anthropogenic disturbances including mining, agriculture, deforestation, and more is often best answered with historical time series. Unfortunately, a lack of long-term monitoring data can make this difficult; paleolimnology offers an alternative, allowing for the reconstruction of past conditions using proxies from sediment records. As part of the nationally funded Canadian Lake Pulse Network, we analyzed sediment cores from 116 lakes across Canada using micro-X-ray fluorescence core-scanning (µXRF). µXRF served to generate abundance profiles for several elements (e.g., Ca, Sr, Ti, Pb, Cu, Zn), allowing for the assessment of spatiotemporal geochemical changes in Canadian lakes dating back to ~1850 AD. We calibrated µXRF core-scanning with conventional geochemical methods in a 48-lake subset and found strong correlations for numerous elements between conventional wet chemistry and µXRF-measured concentrations (Zilkey et al., accepted, Environmental Advances). We then assessed the temporal variability in sediment cores using constrained hierarchical cluster analysis and generalized additive models. Our preliminary results indicate that geochemical change demonstrates significant regional structure. On balance, lakes in eastern Canada predominantly demonstrated a temporal enrichment in metallic elements (e.g., Pb and Zn), while lakes in central and western Canada had a temporal enrichment of elements commonly associated with catchment erosion (e.g., Ti, Sr, K). Our results highlight the heterogeneity in responses across a vast landscape with diverse geological characteristics and land uses, and in the relative importance of anthropogenic disturbances shaping lake sediment geochemistry over time. Key next steps include the investigation of lakes that are distinct relative to their regional trends and the local environmental factors that might explain their contrasting response.

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Fichiers liés : EGU24-16100-print.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/04/2024
• Auteurs : Jean Baptiste BeauvalZine-Eddine KheneRazvan RahotaArnaud MejeanNicolas DoumercMorgan RoupretPhilippe PaparelArnauld VillersFranck BruyereCédric LebacleFrançois Xavier NouhaudCécile ChampyAlexandre de la TailleHervé LangJérome RizkMatthieu DurandCharles DarianeThomas CharlesRomain BoissierJean Alexandre LongPierre BigotKarim BensalahJean Christophe Bernhard
• Organismes : Clinique La Croix du Sud Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Clinique La Croix du Sud CIC - HEGP Centre Hospitalier Universitaire de Nice
• Publié dans World Journal of Urology le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 05/04/2024
• Auteurs : Penelope JordanCamille VerebiBerenice HervéSandrine PerolZeina ChakhtouraCarine CourtillotAnne BachelotDaphne KarilaCeline RenardVirginie GrouthierStanislas Mulot de la CroixValerie BernardCorinne FouveautAude Brac de la PerrièreSophie Jonard-CatteauPhilippe TouraineGenevieve Plu-BureauJean Michel DupontSophie Christin-MaitreThierry Bienvenu
• Organismes : Hôpital Cochin [AP-HP] Université Sorbonne Paris Cité Hôpital Cochin [AP-HP] Université Sorbonne Paris Cité Hôpital Cochin [AP-HP] Université Sorbonne Paris Cité Hôpital Cochin [AP-HP] Université Sorbonne Paris Cité CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université CHU Saint-Antoine [AP-HP] Sorbonne Université CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Universitaire de Bordeaux CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Universitaire de Bordeaux Hôpital Cochin [AP-HP] Université Sorbonne Paris Cité Hospices Civils de Lyon Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Hôpital Jeanne de Flandre [Lille] CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université Hôpital Cochin [AP-HP] Université Sorbonne Paris Cité Hôpital Cochin [AP-HP] Université Sorbonne Paris Cité CHU Saint-Antoine [AP-HP] Sorbonne Université Hôpital Cochin [AP-HP]
• Publié dans Clinical Genetics le 30/10/2020

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Résumé : Pathogenic germline variants in the FOXL2 gene are associated with Blepharophimosis, Ptosis, and Epicanthus Inversus syndrome (BPES) in humans, an autosomal dominant condition. Two forms of BPES have emerged: (i) type I (BPES-I), characterized by ocular signs and primary ovarian failure (POI), and (ii) type II (BPES-II) with no systemic associations. This study aimed to compare the distribution of FOXL2 variants in idiopathic POI/DOR (diminished ovarian reserve) and both types of BPES, and to determine the involvement of FOXL2 in non-syndromic forms of POI/DOR. We studied the whole coding region of the FOXL2 gene using next-generation sequencing in 1282 patients with non-syndromic POI/DOR. Each identified FOXL2 variant was compared to its frequency in the general population, considering ethnicity. Screening of the entire coding region of the FOXL2 gene allowed us to identify 10 different variants, including nine missense variants. Of the patients with POI/DOR, 14 (1%) carried a FOXL2 variant. Significantly, six out of nine missense variants (67%) were overrepresented in our POI/DOR cohort compared to the general or specific ethnic subgroups. Our findings strongly suggest that five rare missense variants, mainly located in the C-terminal region of FOXL2 are high-risk factors for non-syndromic POI/DOR, though FOXL2 gene implication accounts for approximately 0.54% of non-syndromic POI/DOR cases. These results support the implementation of routine genetic screening for patients with POI/DOR in clinical settings.

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Fichiers liés : Clinical Genetics - 2024 - Jordan - Shifting the landscape Dominant C‐terminal rare missense FOXL2 variants in.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/04/2024
• Auteurs : Margherita FabbriVanessa RousseauJean-Christophe CorvolAgnès SommetFlorence TubachYann De RyckeNathalie BertilleYajiththa SelvarasaStephanie CarvalhoVéronique ChaigneauChristine Brefel-CourbonFabienne Ory-MagneSamuel TessierFazia Mélissa TirMatthieu BereauWassilios MeissnerClaire ThiriezAna MarquesPhilippe RemyVincent SchneiderElena MoroLuc DefebvreJean-Luc HouetoStéphane PrangeAlexandre EusebioChristian GenySolène FrismandPhilippe DamierCaroline Giordana ReutherGiovanni CastelnovoIsabelle BenatruAnne Doe de MaindrevilleSophie DrapierDavid MaltêteOuhaid Lagha-BoukbizaOlivier RascolMickael AubignatEloi MagninPr Pierre BurbaudPr Dominique GuehlAlexandra Foubert-SamierBrice LaurensThomas BoraudSylvain VergnetDavid BendetowiczThomas PalpacuerBérengère DebillyPhilippe DerostCharlotte BealHayet SalhiAlice DormeuilAimée PetitAlban GravierGwendoline DupontLucie GarnierValérie FraixAnna CastriotoSara MeoniNicolas CarriereTeodor DanailaChloé LaurencinStéphane ThoboisJean-Philippe AzulayFrédérique FluchereMahmoud CharifMarie-Christine PicotLucie HopesAnne-Gaelle CorbilleTiphaine RouaudPascal DerkinderenCosmin AlecuCharlotte HeraudMarie de VerdalBertrand DegosGraziella MangoneSara SambinAymeric LanoreThomas CourtinLouise-Laure MarianiDavid BendetowiczFouad KhouryPoornima MenonFlorence Cormier-DequaireEmmanuel Flamand-RozeDavid GrabliElodie HainqueMarie VidhailletAurélie MeneretCécile DelormeCendrine FoucardFlorian von RaisonAlexis ElbazAndreas HartmannVincent LeclercqSolène AnsquerFrederique LehMarion LeclercqGuillaume CostentinChristine Brefel CourbonClemence LeungHélène CatalaAstrid CauselEmilie GaiffeSandrine DupouySandrine VillarsWei-Ho LaiRachida BariDamien ChevanneElodie DurandIsabelle RieuStephane BernardCorinne GarsaultNoel BoudjemaPascale GrebentAndrea KistnerPierre PelissierValérie SantraineThomas GaudinPierre BoutetCatherine CaireManel NouiraClaudia VernaAmory JardelSalomé PuisieuxGuillemette ClementLili Le MonnierRégis FrenaisSéverine Le DilyRachel ChaigneauVanessa FerrierElodie DavidLeslie FraElsa FoucaranCarole Dongmo-KenfackFlorence BeauzorMickael LeSonia MessarSophie LiotÉmilie RaboisMargaux Bonnaire-VerdierFrançoise KestensRozenn GourhanSandra Lopez-AlfaroJean-François HouvenaghelMélanie AlexandreChristine BourdonnaisLinda VernonAhmed BoumedieneCéline JulieAurette LobsteinNadine LongatoMarie-Pierre MitterleClélie PhilipsHugo RummelStéphanie BrasEstelle HarrochClaudia Gillet
• Organismes : Centre d'investigation clinique de Toulouse Centre d’Excellence en Maladies Neurodégénératives Toulouse NeuroImaging Center Plateforme F-CRIN Centre d'investigation clinique de Toulouse Plateforme F-CRIN Institut du Cerveau = Paris Brain Institute Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] Centre d'investigation clinique de Toulouse Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique Institut Pierre Louis d'Epidémiologie et de Santé Publique Plateforme F-CRIN Institut du Cerveau = Paris Brain Institute Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] Plateforme F-CRIN Institut du Cerveau = Paris Brain Institute Centre d'investigation clinique Neurosciences [CHU Pitié Salpêtrière] Plateforme F-CRIN Plateforme F-CRIN Centre d'investigation clinique de Toulouse Plateforme F-CRIN Département Neurologie [CHU Toulouse] Toulouse NeuroImaging Center Centre Régional de PharmacoVigilance [CHU Toulouse] Service de neurologie [Amiens] Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Plateforme F-CRIN Service de Neurologie [CHRU Besançon] Centre de référence de l’atrophie multisystématisée [CHU Toulouse] Institut des Maladies Neurodégénératives [Bordeaux] University of Otago [Dunedin, Nouvelle-Zélande] New Zealand Brain Research Institute Plateforme F-CRIN Service de Neurologie [CHU Caen] Plateforme F-CRIN Neuro-Psycho Pharmacologie des Systèmes Dopaminergiques sous-corticaux Plateforme F-CRIN Institut Mondor de Recherche Biomédicale Plateforme F-CRIN Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Plateforme F-CRIN Unité Médicale des Troubles du Mouvement European Academy of Neurology [Vienna, Austria] Plateforme F-CRIN Lille Neurosciences & Cognition - U 1172 Plateforme F-CRIN Epidémiologie des Maladies Chroniques en zone tropicale Service de neurologie C, centre expert parkinson Université Claude Bernard Lyon 1 Institut des sciences cognitives Marc Jeannerod - Centre de neuroscience cognitive - UMR5229 Plateforme F-CRIN Service de neurologie et pathologie du mouvement Plateforme F-CRIN EuroMov - Digital Health in Motion Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Plateforme F-CRIN Centres Mémoire de Ressources et de Recherche [CHRU Nancy] Plateforme F-CRIN Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Plateforme F-CRIN Service de Neurologie [CHU Nice] Plateforme F-CRIN Service de Neurologie [CHU Nimes] Plateforme F-CRIN CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Plateforme F-CRIN Hôpital Maison Blanche Plateforme F-CRIN Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Plateforme F-CRIN Service de neurologie [Rouen] Neuroendocrine, Endocrine and Germinal Differentiation Communication Plateforme F-CRIN Hôpital Maison Blanche Centre d'investigation clinique de Toulouse Centre d’Excellence en Maladies Neurodégénératives Toulouse NeuroImaging Center Plateforme F-CRIN Bordeaux population health
• Publié dans Journal of Neural Transmission le 25/10/2020

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Résumé : Objective: To assess amantadine use and associated factors in the patients with Parkinson's disease (PD). Background: Immediate-release amantadine is approved for the treatment of PD and is largely used in clinical practice to treat "levodopa-induced dyskinesia (LIDs). Its use varies according to countries and PD stages. The prospective NS-Park cohort collects features of PD patients followed by 26 French PD Expert Centres. Methods: Variables used for the analyses included demographics, motor and non-motor PD symptoms and motor complications [motor fluctuations (MFs), LIDs)], antiparkinsonian pharmacological classes and levodopa equivalent daily dose (LEDD). We evaluated: (i) prevalence of amantadine use and compared clinical features of amantadine users vs. non-users (cross-sectional analysis); (ii) factors associated with amantadine initiation (longitudinal analysis); (iii) amantadine effect on LIDs, MFs, apathy, impulse control disorders and freezing of gait (Fog) (longitudinal analysis). Results: Amantadine use prevalence was 12.6% (1,585/12,542, median dose = 200 mg). Amantadine users were significantly younger, with longer and more severe PD symptoms, greater LEDD and more frequent use of device-aided/surgical treatment. Factors independently associated with amantadine initiation were younger age, longer PD duration, more frequent LIDs, MFs and FoG, higher LEDD and better cognitive function. 9 of the 658 patients on amantadine had stopped it at the following visit, after 12-18 months (1.3%). New users of amantadine presented a higher improvement in LIDs and MF compared to amantadine never users. Conclusions: About 12% of PD patients within the French NS-Park cohort used amantadine, mostly those with younger age and more severe PD. Amantadine initiation was associated with a subsequent reduction in LIDs and MFs.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/04/2024
• Auteurs : Jean-Philippe GoiranCamille GonçalvesCécile VittoriGilles BrocardAdele BertiniMarco Leporati PersianoFabio CianchiAlessandro ConfortiGuillaume JouveLaurent MattioChristophe BenechLionel DarrasQuentin VitaleBrahimsamba BomouPierre SabatierMaxime DebretKevin JacqAnne-Lise DevelleChristine OberlinGilles van Heems
• Organismes : ARCHEORIENT - Environnements et sociétés de l'Orient ancien ARCHEORIENT - Environnements et sociétés de l'Orient ancien Laboratoire Image, Ville, Environnement ARCHEORIENT - Environnements et sociétés de l'Orient ancien Histoire et Sources des Mondes antiques ARCHEORIENT - Environnements et sociétés de l'Orient ancien Università degli Studi di Firenze = University of Florence = Université de Florence Region Toscane, Italie Oasi WWF Maremma Istituto per lo studio degli impatti Antropici e Sostenibilità in ambiente marino Exail (iXblue) Exail (iXblue) ARCHEORIENT - Environnements et sociétés de l'Orient ancien ARCHEORIENT - Environnements et sociétés de l'Orient ancien ARCHEORIENT - Environnements et sociétés de l'Orient ancien Études et valorisations archéologiques Institut des sciences de la terre [Lausanne] Environnements, Dynamiques et Territoires de Montagne Morphodynamique Continentale et Côtière Environnements, Dynamiques et Territoires de Montagne Laboratoire d'Informatique, Systèmes, Traitement de l'Information et de la Connaissance Environnements, Dynamiques et Territoires de Montagne Archéologie et Archéométrie Université Lumière - Lyon 2 Histoire et Sources des Mondes antiques Centre Alfred Ernout - Linguistique latine

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Fichiers liés : Conférence Urbi et Orb_JournéesIMU2024.pdf

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