Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 10/03/2003
• Auteurs : Catherine DodéJacqueline LevilliersJean-Michel DupontAnne de PaepeNathalie Le DûNadia Soussi-YanicostasRoney CoimbraSedigheh DelmaghaniSylvie Compain-NouailleFrançoise BaverelChristophe PêcheuxDominique Le TessierCorinne CruaudMarc DelpechFrank SpelemanStefan VermeulenAndrea AmalfitanoYvan BachelotPhilippe BouchardSylvie CabrolJean-Claude CarelHenriette Delemarre-van de WaalBarbara Goulet-SalmonMarie-Laure KottlerOdile RichardFranco Sanchez-FrancoRobert SauraJacques YoungChristine PetitJean-Pierre Hardelin
• Organismes : Institut Cochin Hôpital Cochin [AP-HP] Génétique des Déficits Sensoriels Institut Cochin Hôpital Cochin [AP-HP] Ghent University Hospital Institut Cochin Hôpital Cochin [AP-HP] Génétique des Déficits Sensoriels Génétique des Déficits Sensoriels Génétique des Déficits Sensoriels Génétique des Déficits Sensoriels Institut Cochin Hôpital Cochin [AP-HP] Institut Cochin Hôpital Cochin [AP-HP] Institut Cochin Hôpital Cochin [AP-HP] Genoscope - Centre national de séquençage [Evry] Institut Cochin Hôpital Cochin [AP-HP] Ghent University Hospital Ghent University Hospital Duke University Medical Center Hôpital Michallon CHU Saint-Antoine [AP-HP] CHU Trousseau [APHP] Hôpital Saint-Vincent de Paul VU University Medical Center [Amsterdam] Centre Hospitalier Intercommunal Alençon-Mamers CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Instituto de Salud Carlos III [Madrid] Hôpital Pellegrin Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Génétique des Déficits Sensoriels Génétique des Déficits Sensoriels
• Publié dans Nature Genetics le 29/10/2020

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Résumé : We took advantage of overlapping interstitial deletions at chromosome 8p11–p12 in two individuals with contiguous gene syndromes and defined an interval of roughly 540 kb associated with a dominant form of Kallmann syndrome, KAL2. We establish here that loss-of-function mutations in FGFR1 underlie KAL2 whereas a gain-of-function mutation in FGFR1 has been shown to cause a form of craniosynostosis. Moreover, we suggest that the KAL1 gene product, the extracellular matrix protein anosmin-1, is involved in FGF signaling and propose that the gender difference in anosmin-1 dosage (because KAL1 partially escapes X inactivation) explains the higher prevalence of the disease in males.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2003
• Auteurs : Hélène MarchandinEstelle Jumas-BilakBernard GayCorinne TeyssierHélène Jean-PierreMichèle Siméon de BuochbergChristian CarrièreJean-Philippe Carlier
• Organismes : Département de Bactériologie-Virologie [CHRU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Equipe Pathogènes et Environnements, UMR 5119-ECOSYM Virologie et pathogenèse virale EA3755 Laboratoire universitaire d'antibiologie Laboratoire de Bactériologie Université de Montpellier
• Publié dans International Journal of Systematic and Evolutionary Microbiology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2003
• Auteurs : Victor AboyansPhilippe LacroixArnaud LebourdonPierre-Marie PreuxJean FerrièresMarc Laskar
• Organismes : Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges] Neuroépidémiologie Tropicale et Comparée Neuroépidémiologie Tropicale et Comparée Laboratoire de Biostatistique et d'Informatique Médicale Service de l'Information Médicale et de l'Évaluation [CHU Limoges] Epidémiologie et Analyses en Santé Publique : risques, maladies chroniques et handicap Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges]
• Publié dans Journal of Clinical Epidemiology le 01/11/2020

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Résumé : To propose a standardization of calculus of the ankle-arm index as a diagnostic tool in the clinical setting and epidemiology of peripheral arterial disease, we aimed to study the reproducibility of its measurement through 15 different modes of calculation. The study was performed in a group of 194 vascular laboratory outpatients of a tertiary center. The intra- and interobserver variability was assessed by the intraclass correlation coefficient of agreement and the Bland & Altman method. Methods where the numerator was calculated by the average of posterior tibial and dorsalis pedis artery systolic pressures revealed to be the best reproducible. According to this study and former researches on this topic, we recommend the use of the average of posterior tibial and dorsalis pedis artery systolic pressures of the weakest limb for the numerator and the average of systolic pressures of humeral arteries for the denominator of the ankle-arm index.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2003
• Auteurs : Dominique TournierXavier JordàPhilippe GodignonDominique PlansonJean-Pierre ChanteFranck Sarrus
• Organismes : Centro Nacional de Microelectronica [Spain] Centro Nacional de Microelectronica [Spain] Centre de génie électrique de Lyon Ampère Ferraz
• Publié dans Diamond and Related Materials le 01/11/2020

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Résumé : SiC-based devices are very suitable for high current and high voltage applications [H. Matsunami, Progress in wide bandgap semiconductor SiC for power devices, Invited Paper, ISPSD'00 22-25 May 2000, Toulouse]. Nevertheless, SiC material has some limitations that constrain the capability of these devices. This work is devoted to the design and fabrication of a new etched VJFET, which implements both gate and source in buried layers. This technological approach enables more flexibility in the basic cell layout design (square cells) than the conventional surface gate implementation. Therefore, various geometrical layouts have been investigated in order to find a trade-off between current density, driving ability and current limiting capability. The minimum lithography feature, reactive ion etching and the minimum spacing between adjacent implantations were key points in setting-up the design rules. I-V curves of the designed structures for a gate-to-source bias of 0 and -30 V has been performed at room temperature. All devices exhibit a current saturation at an on-state voltage higher than 10 V. The dependence of the internal access gate resistance on the layout has been checked by means of transconductance measurements. Transconductance has been estimated for each type of structure, being in the range of 57.8-672 mS/mm.. Nevertheless, a new figure of merit (the transconductance per active area) allows to find out the most suitable layout in terms of output current density and gate resistance. A comparison in terms of current and transconductance per source gives the best solution in terms of output saturation current and gate resistance. The results of those measurements are discussed with future perspectives for implementation of the most appropriated layout in an integrated system.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/02/2003
• Auteurs : L. GrunerJacques CabaretFrancis F. BarilletJean Michel J. M. ElsenPierre DelattreJean Pierre QuéréPhilippe JacquietOlivier AndréolettiPierre SarradinJ.M. ArranzA. GarciaT. Hallas
• Organismes : Station de Pathologie aviaire et parasitologie [Nouzilly] Station de Pathologie aviaire et parasitologie [Nouzilly] Station d'Amélioration Génétique des Animaux Station d'Amélioration Génétique des Animaux Unité expérimentale de Lutte Biologique Unité associée de Physiopathologie respiratoire des ruminants Unité associée de Physiopathologie respiratoire des ruminants Unité de Pathologie Infectieuse et Immunologie [Nouzilly]

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2003
• Auteurs : Albert HagègeClaire CarrionPhilippe MenaschéJean-Thomas VilquinDenis DubocJean-Pierre MarolleauMichel DesnosPatrick Bruneval
• Organismes : Centre de recherche en Myologie – U974 SU-INSERM Centre de recherche en Myologie – U974 SU-INSERM
• Publié dans The Lancet le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2003
• Auteurs : Jean-Yves JaffrayPhilippe Mongin
• Organismes : Systèmes d'aide à la décision et à la formation
• Publié dans Theory and Decision le 22/10/2020

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Résumé : The paper extends a result in Dutta and Ray's (1989) theory of constrained egalitarianism initiated by relying on the concept of proportionate rather than absolute equality. We apply this framework to redistributive systems in which what the individuals get depends on what they receive or pay qua members of generally overlapping groups. We solve the constrained equalization problem for this class of models. The paper ends up comparing our solution with the alternative solution based on the Shapley value, which has been recommended in some distributive applications.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2003
• Auteurs : Magdalini KypriotouMagali Fossard-DemoorChristos E ChadjichristosChafik GhayorBenoit de CrombruggheJean-Pierre PujolPhilippe Galéra
• Organismes : Université de Caen Normandie Université de Caen Normandie CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Université de Caen Normandie Université de Caen Normandie Université de Caen Normandie Université de Caen Normandie Université de Caen Normandie
• Publié dans DNA and Cell Biology le 01/11/2020

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Résumé : As a key transcription factor in cartilage formation, SOX9 is a potent activator of type II collagen expression, a phenotypic marker of articular chondrocytes. This study was designed to determine the potential role of SOX9 on COL2A1 gene transcription during chondrocyte dedifferentiation, a characteristic feature of osteoarthritic cartilage that can be partially mimicked in vitro by subculturing primary chondrocytes. Constructs containing different regions from the promoter and the first intron of human COL2A1 gene were transfected in differentiated (primary) and dedifferentiated (passaged) rabbit articular chondrocytes (RAC), together with an expression vector containing or not the SOX9 cDNA. As expected, low levels of SOX9 overexpression were capable of enhancing COL2A1 gene transcription in both fully differentiated and slightly phenotypically altered chondrocytes, through the specific intronic enhancer. In contrast, when overexpressed at high levels, SOX9 induced an inhibition of COL2A1 gene expression, mediated by the -266 bp promoter region, whatever the differentiation state of chondrocytes. However, in the advanced stages of dedifferentiation, SOX9, independently of its expression level, depressed COL2A1 transcriptional activity through the -63 bp short promoter. Although SOX9 has a crucial role in chondrocyte differentiation, our findings indicate that this factor cannot restore the phenotype of osteoarthritic chondrocytes by itself.

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• Type de publi. : Article dans une revue
• Date de publi. : 31/01/2003
• Auteurs : Arlette MaretJerome D CoudertLucile GaridouFoucras G.Pierre GourdyAndrée KrustSonia DupontPierre ChambonPhilippe DruetFrancis BayardJean-Charles Guéry
• Organismes : Endocrinologie et communication cellulaire Centre Hospitalier Universitaire de Toulouse Centre de Physiopathologie de Toulouse-Purpan Institut Claude de Préval Centre Hospitalier Universitaire de Toulouse Centre de Physiopathologie de Toulouse-Purpan Institut Claude de Préval Centre Hospitalier Universitaire de Toulouse Centre de Physiopathologie de Toulouse-Purpan Institut Claude de Préval Centre Hospitalier Universitaire de Toulouse Endocrinologie et communication cellulaire Centre Hospitalier Universitaire de Toulouse Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Institut de génétique et biologie moléculaire et cellulaire Centre de Physiopathologie de Toulouse-Purpan Centre Hospitalier Universitaire de Toulouse Institut Claude de Préval Endocrinologie et communication cellulaire Centre Hospitalier Universitaire de Toulouse Centre de Physiopathologie de Toulouse-Purpan Centre Hospitalier Universitaire de Toulouse Institut Claude de Préval
• Publié dans European Journal of Immunology le 22/10/2020

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Résumé : It is widely accepted that females have superior immune responses than males, but the ways by which sex hormones may enhance T cell responses are still poorly understood. In the present study, we analyzed the effect of estrogens on CD4 T cell activation and differentiation after immunization with exogenous antigens. We show that administration of low doses of 17beta-estradiol (E2) to castrated female mice results in a striking increase of antigen-specific CD4 T cell responses and in the selective development of IFN-gamma-producing cells. Quantitative assessment of the frequency of T cells bearing a public TCR beta chain CDR3 motif demonstrated that the clonal size of primary antigen-specific CD4 T cells was dramatically increased in immune lymph nodes from E2-treated mice. By using mice with disrupted estrogen receptor (ER) alpha or beta genes, we show that ERalpha, but not ERbeta, was necessary for the enhanced E2-driven Th1 cell responsiveness. Furthermore, ERalpha expression in hematopoietic cells was essential, since E2 effects on Th1 responses were only observed in mice reconstituted with bone marrow cells from ERalpha+/+, but not ERalpha-deficient mice. These results demonstrate that estrogen administration promotes strong antigen-specific Th1 cell responses in a mechanism that requires functional expression of ERalpha in hematopoietic cells.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2003
• Auteurs : Marie-Christine Chartier-HarlinAlexis ElbazJacqueline ClavelFlorence RichardJean-Sébastien VidalPhillippe AmouyelChristophe TzourioAnnick AlpérovitchMarie-Christine Chartier-Harlin
• Organismes : Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations Neuroépidémiologie Recherches épidémiologiques et statistiques sur l'environnement et la santé. Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations CHU Saint-Antoine [AP-HP] Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations Neuroépidémiologie Neuroépidémiologie Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations
• Publié dans Human Molecular Genetics le 26/10/2020

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Résumé : Excess of nitric oxide (NO) has been shown to exert neurotoxic impacts in the brain. Moreover, inhibition of two NO-synthesizing enzymes, neuronal NOS (nNOS) and inducible NOS (iNOS), displays neuroprotective effects in the MPTP model of Parkinson's disease (PD). These data suggest a possible involvement of NOS as factors controlling the resistance of the nigral dopaminergic neurons to environmental insults. Therefore, we investigated whether polymorphisms present in these genes could contribute to the risk of developing PD. We carried out a community-based case-control study among subjects enrolled in the Mutualit?ociale Agricole, the French health insurance organization for workers connected to agriculture. Two-hundred and nine PD patients and 488 controls of European (mostly French) ancestry and matched for age, sex and region of residency were included in this study. Associations were observed with polymorphisms present in exon 22 of iNOS (OR for AA carriers=0.50, 95% CI=0.29-0.86, P=0.01) and in exon 29 of nNOS (OR for carriers of the T allele=1.53, 95% CI=1.08-2.16, P=0.02); no association was observed with a polymorphism in exon 18 of nNOS (OR for carriers of the T allele=1.20, 95% CI=0.85-1.69, P=0.30). Moreover, a significant interaction of the nNOS polymorphisms with current and ever cigarette smoking was found (nNOS 18, P=0.05; nNOS 29, P=0.04). All together, these data favour an involvement of these two genes as new modifier genes in PD.

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