Philippe JEAN-PIERRE

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• Type de publi. :
• Date de publi. : 01/01/2005
• Auteurs : Jean-Yves DourmadBernard FostierBénédicte LebretPhilippe LecouveyJean NobletYvon SalaünPierre P. Sellier
• Organismes : Systèmes d'Elevage, Nutrition Animale et Humaine Institut Technique du Porc Systèmes d'Elevage, Nutrition Animale et Humaine Institut Technique du Porc Systèmes d'Elevage, Nutrition Animale et Humaine Institut Technique du Porc Station de Génétique Quantitative et Appliquée

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2005
• Auteurs : Fabien MalbetJean-Philippe BergerPaulo GarciaPierre KernKarine PerrautMyriam BenistyLaurent JocouEmilie HerwatsJean-Baptiste LebouquinPierre LabeyeEtienne Le CoarerOlivier PreisEric TatulliÉric Thiébaut
• Organismes : Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Centro de Astrofísica da Universidade do Porto Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Laboratoire d'Astrophysique de Grenoble Centre de Recherche Astrophysique de Lyon

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Résumé : The VITRUV project has the objective to deliver milli-arcsecond spectro-images of the environment of compact sources like young stars, active galaxies and evolved stars to the community. This instrument of the VLTI second generation based on the integrated optics technology is able to combine from 4 to 8 beams from the VLT telescopes. Working primarily in the near infrared, it will provide intermediate to high spectral resolutions and eventually polarization analysis. This paper summarizes the result from the concept study led within the Joint Research Activity advanced instruments of the OPTICON program.

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Fichiers liés : malbet-vitruv.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : C. MendibidePhilippe SteyerJean-Pierre Millet
• Organismes : Matériaux, ingénierie et science [Villeurbanne] Matériaux, ingénierie et science [Villeurbanne]
• Publié dans Surface and Coatings Technology le 31/10/2020

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Résumé : Corrosion resistance of nanomultilayered TiN/CrN coatings has been evaluated in saline aqueous neutral solution and compared with monolayered TiN and CrN references. Coatings have been deposited by magnetron sputtering on M2 tool steel, as well as on glass strip, to determine their intrinsic electrochemical behavior. Corrosion resistance afforded by CrN is better than TiN, which is explained by the formation of a thin oxide passive film with favorable semiconductive properties. Nanostratified structure improves the coating density, but the electrochemical behavior is however mainly controlled by the nature of the outer layer, which must be CrN to optimize protection ability.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : David AzriaFrédéric BibeauNicolas BarbierAbderrahim ZouhairClaire LemanskiPhilippe RouanetMarc YchouPierre SenesseMahmut OzsahinAndré PèlegrinJean-Bernard DuboisSimon Thezenas
• Organismes : Département de radiothérapie Immunociblage des Tumeurs et Ingenierie des Anticorps Laboratoire d'anatomo-pathologie Département de radiothérapie Département de radiothérapie Département de Radiothérapie Département de radiothérapie Département de chirugie oncologique Immunociblage des Tumeurs et Ingenierie des Anticorps Département d'oncologie médicale et digestive Département d'oncologie médicale et digestive Département de Radiothérapie Immunociblage des Tumeurs et Ingenierie des Anticorps Département de radiothérapie Unité de Biostatistiques
• Publié dans BMC Cancer le 01/11/2020

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Résumé : BACKGROUND: Epidermal growth factor receptor (EGFR) represents a major target for current radiosensitizing strategies. We wished to ascertain whether a correlation exists between the expression of EGFR and treatment outcome in a group of patients with rectal adenocarcinoma who had undergone preoperative radiotherapy (RT). METHODS: Within a six-year period, 138 patients underwent preoperative radiotherapy and curative surgery for rectal cancer (UICC stages II-III) at our institute. Among them, 77 pretherapeutic tumor biopsies were available for semi-quantitative immunohistochemical investigation evaluating the intensity and the number (extent) of tumor stained cells. Statistical analyses included Cox regression for calculating risk ratios of survival endpoints and logistic regression for determining odds ratios for the development of loco-regional recurrences. RESULTS: Median age was 64 years (range: 30-88). Initial staging showed 75% and 25% stage II and III tumors, respectively. RT consisted of 44-Gy pelvic irradiation in 2-Gy fractions using 18-MV photons. In 25 very low-rectal-cancer patients the primary tumor received a boost dose of up to 16 Gy for a sphincter-preservation approach. Concomitant chemotherapy was used in 17% of the cases. All patients underwent complete total mesorectal resection. Positive staining (EGFR+) was observed in 43 patients (56%). Median follow-up was 36 months (range: 6-86). Locoregional recurrence rates were 7 and 20% for EGFR extent inferior and superior to 25%, respectively. The corresponding locoregional recurrence-free survival rate at two years was 94% (95% confidence interval, CI, 92-98%) and 84% (CI 95%, 58-95%), respectively (P = 0.06). Multivariate analyses showed a significant correlation between the rate of loco-regional recurrence and three parameters: EGFR extent superior to 25% (hazard ratio = 7.18, CI 95%, 1.17-46, P = 0.037), rectal resection with microscopic residue (hazard ratio = 6.92, CI 95%, 1.18-40.41, P = 0.032), and a total dose of 44 Gy (hazard ratio = 5.78, CI 95%, 1.04-32.05, P = 0.045). CONCLUSION: EGFR expression impacts on loco-regional recurrence. Knowledge of expression of EGFR in rectal cancer could contribute to the identification of patients with an increased risk of recurrences, and to the prediction of prognosis.

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Fichiers liés : 1471-2407-5-62.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Mieke MoermanJean-Pierre MartensLise Crevier-BuchmanVirginie WoisardPhilippe Dejonckere
• Organismes : LPP - Laboratoire de Phonétique et Phonologie - UMR 7018 Hôpital Européen Georges Pompidou [APHP]
• Publié dans Laryngol Otol Rhinol le 16/10/2009

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/01/2005
• Auteurs : Philippe Bordes
• Organismes : LAboratoire de Recherche Historique Rhône-Alpes - UMR5190

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Résumé : L'art du peintre Jacques-Louis David après la Révolution.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2005
• Auteurs : Xavier RodetJean-Philippe LambertRoland CahenFlorian GosselinPascal Mobuchon
• Organismes : Analyse et synthèse sonores [Paris] Analyse et synthèse sonores [Paris] Analyse et synthèse sonores [Paris] Analyse et synthèse sonores [Paris] Analyse et synthèse sonores [Paris]

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Résumé : The Phase project : haptic and visual interaction for music exploration

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2005
• Auteurs : L'Hédi ZaherJean-Pierre CahierXavier PétardJean-Philippe LeboeufClaude Guittard
• Organismes : TECHnologies pour la Coopération, l’Interaction et les COnnaissances dans les collectifs TECHnologies pour la Coopération, l’Interaction et les COnnaissances dans les collectifs Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur Bureau d'Économie Théorique et Appliquée

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Résumé : We present, in this article, a “topic map” system applied to the Open Source Software (OSS) com-munity. Our approach is deliberately open and based on the HyperTopic model created by Tech-CICO lab. Our collective experimentation aims at the construction of a shared information platform that would be visible and useable for the OSS community. Thanks to this platform, OSS commu-nity members can describe and find software appli-cations, by browsing multi-point of view “topic maps”. Everyone may declare the characteristics of a software project following an index structure made of several tree diagrams. Thus, the commu-nity will build, in an ideal case, collective seman-tics “in progress”. We present this project as an example of a “Socio-Semantic Web” (S2W). We also detail the Hyper-Topic model, on which is based our application, and the AGORAE platform which brings this soft-ware application into play. The HyperTopic model is inspired by the simple semantic models of “topic maps”, but it enriches this approach by two new dimensions. First, it aims at improving the repre-sentation of shared meaning artifacts (in this case: software applications), of the social actors and of their activities. Second, this HyperTopic model is a support for debating the meaning of these representations

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Marie-Hélène LindicBrigitte PecquenardPhilippe VinatierAlain LevasseurHervé MartinezDanielle GonbeauEmmanuel PetitGuy Ouvrard
• Organismes : Institut de Chimie de la Matière Condensée de Bordeaux Institut de Chimie de la Matière Condensée de Bordeaux Institut de Chimie de la Matière Condensée de Bordeaux Institut de Chimie de la Matière Condensée de Bordeaux Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux Laboratoire de Chimie théorique et Physico-chimie moléculaire Institut des Matériaux Jean Rouxel Institut des Matériaux Jean Rouxel
• Publié dans Thin Solid Films le 22/10/2020

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Résumé : Different titanium oxysulfide thin films were prepared by rf magnetron sputtering using two types of targets in a pure argon or mixed oxygen/argon atmosphere with a total pressure of 1 or 0.2 Pa. We have studied the influence of the sputtering conditions (target, total pressure, oxygen partial pressure) on the composition, the morphology and the local and electronic structure of our thin films. A set of complementary techniques (scanning electron microscopy, X-ray diffraction, transmission electron microscopy, X-ray photoelectron spectroscopy (XPS) and X-ray absorption spectroscopy (XAS)) was used to characterize the thin films. Two types of films have been obtained: thin films prepared from TiS2 target having a composition and a local structure close to TiS3 and thin films obtained from TiS2/TiS3 target characterized by a composition and a local structure close to TiS2. The complementary use of XPS and sulfur K-edge XAS spectroscopies has allowed us to evidence the coexistence of different microdomains into the thin films corresponding respectively to a pure sulfur, a pure oxygen or a mixed sulfur/oxygen environment.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2005
• Auteurs : Frédéric MoretLionel ChristiaenCarole DeytsMarylin BlinPhilippe VernierJean-Stéphane Joly
• Organismes : Développement, évolution et plasticité du système nerveux Institut de Neurobiologie Alfred Fessard - Laboratoire de Physiologie Nerveuse Développement, évolution et plasticité du système nerveux Institut de Neurobiologie Alfred Fessard - Laboratoire de Physiologie Nerveuse Développement, évolution et plasticité du système nerveux Neurobiologie des processus adaptatifs Développement, évolution et plasticité du système nerveux Développement, évolution et plasticité du système nerveux Institut de Neurobiologie Alfred Fessard - Laboratoire de Physiologie Nerveuse Développement, évolution et plasticité du système nerveux Institut de Neurobiologie Alfred Fessard - Laboratoire de Physiologie Nerveuse
• Publié dans Developmental Biology le 02/11/2020

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Résumé : In extant chordates, the overall patterning along the anteroposterior and dorsoventral axes of the neural tube is remarkably conserved. It has thus been proposed that four domains corresponding to the vertebrate presumptive forebrain, midbrain-hindbrain transition, hindbrain, and spinal cord were already present in the common chordate ancestor. To obtain insights on the evolution of the patterning of the anterior neural tube, we performed a study aimed at characterizing the expression of regulatory genes in the sensory vesicle of Ciona intestinalis, the anteriormost part of the central nervous system (CNS) related to the vertebrate forebrain, at tailbud stages. Selected genes encoded primarily for homologues of transcription factors involved in vertebrate forebrain patterning. Seven of these genes were expressed in the ventral sensory vesicle. A prominent feature of these ascidian genes is their restricted and complementary domains of expression at tailbud stages. These patterning markers thus refine the map of the developing sensory vesicle. Furthermore, they allow us to propose that a large part of the ventral and lateral sensory vesicle consists in a patterning domain corresponding to the vertebrate presumptive hypothalamus.

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