Philippe JEAN-PIERRE

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 13/09/2001
• Auteurs : François BermondPhilippe VezinMichelle RametRobert BouquetYves CaireKarine Bruyère-GarnierSabine CompigneJean-Pierre VerriestEric J Voiglio
• Organismes : Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Laboratoire de Biomécanique et Mécanique des Chocs Université Claude Bernard Lyon 1

---

Fichiers liés : koh46843.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2001
• Auteurs : Philippe UlsemerCatherine Strassel-RisserMarie-Jeanne BaasJean SalameroSylvette Chasserot-GolazJean-Pierre CazenaveCorinne de la SalleFrançois Lanza
• Organismes : Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Mécanismes moléculaires du transport intracellulaire Biologie de la communication cellulaire Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose
• Publié dans Biochemical Journal le 28/10/2020

---

Résumé : The multisubunit leucine-rich glycoprotein (GP) Ib–IX–V complex mediates von Willebrand factor-dependent platelet adhesion at sites of blood-vessel injury. Molecular defects of this receptor are reported to cause the Bernard–Soulier haemorrhagic disorder. To gain insight into the mechanisms controlling expression of normal and defective receptors, we performed pulse–chase metabolic studies and detailed analysis of intracellular processing in GPIb-IX-transfected Chinese-hamster ovary cells. In the native complex, after early subunit association, sugars N-linked to the three subunits are trimmed and sialylated in the Golgi compartment and GPIbα undergoes extensive O-glycosylation. Surface biotinylation during chase demonstrated that only fully processed complexes reach the cell surface. Tunicamycin treatment revealed that early N-glycosylation is not required for O-glycosylation of GPIbα and surface expression of the complex. Biosynthetic studies were then performed on a Bernard–Soulier variant based on previous description of abnormal GPIbα size and decreased surface expression. The mutant complex associated normally, but displayed defective processing of its N-linked sugars and abnormal O-glycosylation of GPIbα. Confocal immunofluorescence microscopy revealed that the mutant complexes could reach the cell surface but also accumulated intracellularly, while use of compartment specific markers showed strong co-localization in the endoplasmic reticulum (ER) and ER-to-Golgi intermediate compartments (‘ERGIC’) and only slight labelling of the cis-Golgi. Blockade before the Golgi was confirmed by brefeldin A treatment, which restored O-glycosylation and processing of N-linked sugars. The present study has shown that transfer from the ER to the Golgi represents an important step for controlling post-translational processing and surface expression of normal GPIb-IX-V complex.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 01/09/2001
• Auteurs : Isabelle QuiduJean-Philippe MalkassePierre VilbéGilles Burel
• Organismes : Extraction et Exploitation de l'Information en Environnements Incertains Thales Underwater Systems Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (UMR 3192) Lab-STICC_UBO_CACS_COM

---

Résumé : L'utilisation de sonar haute résolution pour la guerre des mines permet d'envisager la classification d'un objet immergé à partir de l'ombre acoustique portée sur le fond. Le levé des ambiguïtés inhérentes à la classification monovue peut être réalisé en utilisant plusieurs images présentant les ombres acquises selon des points de vue distincts. Nous proposons ainsi d'effectuer une classification supervisée multivues par fusion des attributs caractéristiques extraits d'images sonar constituant trois points de vue imprécis (angles de vue inconnus) d'une même cible. La méthode repose sur l'analyse de la répartition d'attributs caractéristiques extraits d'images sonar haute résolution dans le cadre de la théorie des ensembles flous et la définition de modèles de fusion adaptés. L'évaluation de ces modèles a été réalisée sur une base d'images simulées avec cinq types de mines.

---

Fichiers liés : gretsi01ArticleV1.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 31/08/2001
• Auteurs : Gaëtan MessinJean-Philippe KarrAugustin BaasGalina KhitrovaRomuald HoudréRoss P. StanleyUrsula OesterleElisabeth Giacobino
• Organismes : Laboratoire Kastler Brossel Laboratoire Kastler Brossel Laboratoire Kastler Brossel Optical Sciences Center Institut de Micro et Optoélectronique Institut de Micro et Optoélectronique Institut de Micro et Optoélectronique Laboratoire Kastler Brossel
• Publié dans Physical Review Letters le 02/11/2020

---

Résumé : We present novel experimental results demonstrating the coherence properties of the nonlinear emission from semiconductor microcavities in the strong coupling regime, recently interpreted by parametric polariton four-wave mixing. We use a geometry corresponding to degenerate four-wave mixing. In addition to the predicted threshold dependence of the emission on the pump power and spectral blue shift, we observe a phase dependence of the amplification which is a signature of a coherent polariton wave mixing process.

---

Fichiers liés : paramp6.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 28/08/2001
• Auteurs : G KauffensteinW BergmeierAnita Eckly-MichelPhilippe OhlmannCatherine LeonJean-Pierre CazenaveB NieswandtChristian Gachet
• Organismes :
• Publié dans FEBS Letters le 24/10/2020

---

Résumé : High concentrations of adenosine-5'-diphosphate ADP are able to induce partial aggregation without shape change of P2Y(1) receptor-deficient mouse platelets through activation of the P2Y(12) receptor. In the present work we studied the transduction pathways selectively involved in this phenomenon. Flow cytometric analyses using R-phycoerythrin-conjugated JON/A antibody (JON/A-PE), an antibody which recognizes activated mouse alpha(IIb)beta(3) integrin, revealed a low level activation of alpha(IIb)beta(3) in P2Y(1) receptor-deficient platelets in response to 100 microM ADP or 1 microM 2MeS-ADP. Adrenaline induced no such activation but strongly potentiated the effect of ADP in a dose-dependent manner. Global phosphorylation of (32)P-labeled platelets showed that P2Y(12)-mediated aggregation was not accompanied by an increase in the phosphorylation of myosin light chain (P(20)) or pleckstrin (P(47)) and was not affected by the protein kinase C (PKC) inhibitor staurosporine. On the other hand, two unrelated phosphoinositide 3-kinase inhibitors, wortmannin and LY294002, inhibited this aggregation. Our results indicate that (i) the P2Y(12) receptor is able to trigger a P2Y(1) receptor-independent inside-out signal leading to alpha(IIb)beta(3) integrin activation and platelet aggregation, (ii) ADP and adrenaline use different signaling pathways which synergize to activate the alpha(IIb)beta(3) integrin, and (iii) the transduction pathway triggered by the P2Y(12) receptor is independent of PKC but dependent on phosphoinositide 3-kinase.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2001
• Auteurs : Mehdi KarouiHélène Hofmann-RadvanyiUte ZimmermannAnne CouvelardClaude DegottLaetitia Faridoni-LaurensJean-Charles AhomadegbeSylvie GazzeriElisabeth BrambillaThierry ClericiPeggy CharbonnierChristophe TrésalletEmmanuel MitryChristophe PennaPhilippe RougierCatherine BoileauJean-Paul ThieryBernard NordlingerBrigitte FrancFrançois Radvanyi
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie Service de pathologie [CHU Bichat] Pharmacologie et nouveaux traitements des cancers Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] Groupe de Recherche sur le Cancer du Poumon Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie Laboratoire de Chimie et Biologie des Métaux CHU Pitié-Salpêtrière [AP-HP] Institut Curie [Paris] Hôpital Européen Georges Pompidou [APHP] Service de cardiologie Institute of Molecular and Cell Biology Department of Pathology Compartimentation et dynamique cellulaires
• Publié dans Oncogene le 02/11/2020

---

Résumé : Germline specific point mutations in the gene encoding fibroblast growth factor receptor 3 (FGFR3) are associated with autosomal dominant human skeletal dysplasia and craniosynostosis syndromes. Mutations identical to the germinal activating mutations found in severe skeletal dysplasias have been identified in certain types of cancer: at low frequency in multiple myeloma and cervix carcinoma and at high frequency in bladder carcinoma. We analysed, by SSCP and sequencing, the prevalence of FGFR3 mutations in 116 primary tumours of various types (upper aerodigestive tract, oesophagus, stomach, lung and skin). The regions analysed encompassed all FGFR3 point mutations previously described in severe skeletal dysplasia and cancers. No mutations were detected in the tumour types examined, suggesting that FGFR3 mutations are restricted to a few tumour types, the evidence to date suggesting that they are very specific to bladder carcinomas.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 30/07/2001
• Auteurs : Isabelle QuiduJean-Philippe MalkasseGilles BurelPierre Vilbé
• Organismes : Extraction et Exploitation de l'Information en Environnements Incertains Thales Underwater Systems Lab-STICC_UBO_CACS_COM Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (UMR 3192)

---

Résumé : We propose a new image sonar segmentation by combining two complementary competencies. On the one hand, following an image processing approach, we aim at partitioning raw image data to provide a binary image. On the other hand, we take advantage of technological knowledge such as the principle of sonar image formation. For sonar images, grey-level histogram generally presents a single mode which entails a poor separation of two theoretical modes related to reverberation and shadow subpopulations of the image. The separation of these two modes is of critical interest in a further description of objects from their cast shadows. In this paper, an optimal filter is specified by a criterion which aims at changing the statistical properties of each area while making threshold value selection from the histogram easier. While minimizing the output pixels variance, pixel values in each region concentrate around the respective average value while, simultaneously, two distinct modes appear on the histogram of the filtered image. The minimum value found between the two modes in the smoothed histogram leads to the searched threshold. In addition, we show how filter aspect depends as well on the image sonar resolution as on sonar parameters.

---

Fichiers liés : acivs01filtreSonar.pdf

---

Source

---

• Type de publi. :
• Date de publi. : 12/07/2001
• Auteurs : Laurent GascaC LeclerePierre SansonettiJean Paul BlondelSébastien FévrierJacques MarcouDominique BayartDominique PagnouxPhilippe Roy
• Organismes : Alcatel Research & Innovation Center Alcatel Research & Innovation Center Alcatel Research & Innovation Center Alcatel Research & Innovation Center Institut de Recherche en Communications Optiques et Microondes Institut de Recherche en Communications Optiques et Microondes Alcatel Research & Innovation Center Institut de Recherche en Communications Optiques et Microondes Institut de Recherche en Communications Optiques et Microondes

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 09/07/2001
• Auteurs : Yann H. KerrWigneron J.-P.Philippe WaldteufelJean-Christophe Calvet
• Organismes : Centre d'études spatiales de la biosphère Unité de bioclimatologie Institut Pierre-Simon-Laplace Centre national de recherches météorologiques

---

Résumé : This paper discusses the potential of a L-band 2-D microwave interferometric radiometer for monitoring surface variables over land surfaces. The instrument is the payload of the SMOS Mission (Soil Moisture and Ocean Salinity), selected for phase A studies by the European Space Agency (ESA) in answer to the call for Earth Explorer Opportunity Missions. The L-band radiometer is based on an innovative bi-dimensional aperture synthesis concept. This sensor has new and significant capabilities, especially in terms of multi-angular viewing configurations.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 09/07/2001
• Auteurs : Yann H. KerrPhilippe WaldteufelWigneron J.-P.Jordi FontMichael Berger
• Organismes : Centre d'études spatiales de la biosphère Institut Pierre-Simon-Laplace Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] European Space Research and Technology Centre

---

Résumé : This paper will describe the SMOS concept in terms of instrument (characteristics) investigates the main aspects of the retrieval capabilities of the 2-D microwave interferometer for monitoring soil moisture, vegetation biomass and surface temperature. The analysis is based on model inversion taking into account the instrument characteristics. The standard error of estimate of the surface variables is computed as a function of the sensor configuration system and of the uncertainties associated with the spatial measurements. The inversion process is based on a standard minimization routine that computes both retrieved variables and standard error associated with the retrievals. The potential of SMOS, depending on the view angle configuration and the use of the sole 1.4 GHz is investigated. The analysis investigates the possibility to retrieve one, two or the three surface variables, depending on the system configuration. These questions are key issues to define the observation configuration of SMOS that meets the scientific requirements and the technical constraints of the spatial missions.

---

Source