Philippe JEAN-PIERRE

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2002
• Auteurs : Philippe BarralJean-Paul GuillaumetPierre Nouvel
• Organismes : Laboratoire Chrono-environnement (UMR 6249) Archéologies, Cultures et Sociétés Laboratoire Chrono-environnement (UMR 6249)

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Fichiers liés : Guillaumet_2002_Barral_Nouvel.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2002
• Auteurs : Philippe RocheLiliane MouawadDavid PerahiaJean-Pierre SamamaDaniel Kahn
• Organismes : Laboratoire de Biologie Moléculaire des Relations Plantes-Microorganismes, UMR 215
• Publié dans Protein Science le 25/10/2020

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Résumé : FixJ is a two-domain response regulator involved in nitrogen fixation in Sinorhizobium meliloti. Recent X-ray characterization of both the native (unphosphorylated) and the active (phosphorylated) states of the protein identify conformational changes of the beta4-alpha4 loop and the conserved residue Phe101 as the key switches in activation. These structures also allowed investigation of the transition between conformations of this two-component regulatory receiver domain by molecular dynamics simulations. The path for the conformational change was studied with a distance constraint directing the system from one state to the other. The simulations provide evidence for a correlation between the conformation of the beta4-alpha4 loop and the orientation of the residue Phe101. A model presenting the sequence of events during the activation/deactivation process is discussed.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2002
• Auteurs : Jean-Pierre FarineEtienne SémonClaude EveraertsDehbia Abed-VieillardPhilippe GrandcolasRémy Brossut
• Organismes : Développement et Communication Chimique chez les Insectes Développement et Communication Chimique chez les Insectes Développement et Communication Chimique chez les Insectes Développement et Communication Chimique chez les Insectes
• Publié dans Journal of Chemical Ecology le 01/11/2020

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Résumé : The volatile constituents of the supposed defensive secretions of the glandular pouches of the adults of both sexes of the cockroach Therea petiveriana have been shown to contain N-3-methylbutylacetamide (MBA) and N-3-methylbutylpropanamide (MBP), which represented 60% of the volatile fraction. The other 40% included acidic, aromatic, and aldehydic compounds. Behavioral experiments demonstrated that the secretion acts as an alarm pheromone for adults.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2002
• Auteurs : Cedric NeveuJean-Philippe SemblatPierre AbadPhilippe Castagnone-Sereno
• Organismes : Unité mixte de recherche interactions plantes-microorganismes et santé végétale Unité mixte de recherche interactions plantes-microorganismes et santé végétale Unité mixte de recherche interactions plantes-microorganismes et santé végétale Unité mixte de recherche interactions plantes-microorganismes et santé végétale
• Publié dans DNA Sequence le 01/11/2020

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Résumé : We report the cloning of a full-length cDNA from the plant-parasitic nematode Meloidogyne incognita, which encodes a putative protein of 1082 amino acids showing high similarity with K-Cl cotransporters (KCCs) from the free-living nematode Caenorhabditis elegans (54% identity) and from a number of mammals, including human. Hydropathy analysis indicates typical KCC topology patterns, with a hydrophylic NH2-terminal region, 12 membrane-spanning domains, and a long COOH-terminal hydrophylic region. Alignment of the nematode sequences with eleven KCC sequences from mammals suggests that the nematode proteins may constitute a separated family of KCCs. The M. incognita gene was shown to be expressed in both motile and sedentary stages, which suggests an important function in general physiology of the nematode. By analogy with known proteins, it is hypothesized that this gene is involved in the regulation of cell osmotic pressure to maintain nematode body fluids hyperosmotic to the environment.

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• Type de publi. :
• Date de publi. : 01/01/2002
• Auteurs : Philippe ContamineJean-Pierre Reverseau
• Organismes : Musée de l'Armée, Paris
• Publié dans Cahiers d'Etudes et de recherches du musée de l'Armée (CERMA) le 24/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2002
• Auteurs : Gérard VergotenJean-Pierre Zanetta Roland Bindeus Guy Normand Viviane Durier Philippe Lagant Emmanuel Maes And Gérard Vergoten
• Organismes : Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
• Publié dans Journal of Biological Chemistry le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2002
• Auteurs : Christelle CeboViviane DurierPhilippe LagantEmmanuel MaesGérard VergotenDoina FloreaTony LefebvreGerard StreckerJean Pierre Zanetta
• Organismes : Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
• Publié dans Journal of Biological Chemistry le 02/11/2020

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Résumé : Interleukin 6 (IL-6) is endowed with a lectin activity for oligosaccharide ligands possessing the HNK-1 epitope (3-sulfated glucuronic acid) found on some mammalian glycoprotein N-glyeans (Cebo, C., Dambrouck, T., Maes, E., Laden, C., Strecker, G., Michalski, J. C., and Zanetta, J. P. (2001) J. Biol. Chem. 276, 56855691). Using high affinity oligosaccharide ligands, it is demonstrated that this lectin activity is responsible for the early dephosphorylation of tyrosine residues found on specific proteins induced by interleukin 6 in human resting lymphocytes. The gp130 glycoprotein, the signal-transducing molecule of the IL-6 pathway, is itself a molecule possessing the HNK-1 epitope. This indicates that IL-6 is a bi-functional molecule able to extracellularly associate its alpha-receptor with the gp130 surface complex. Computational modeling indicates that the lower energy conformers of the high affinity ligands of IL-6 have a common structure. Docking experiments of these conformers suggest that the carbohydrate recognition domain of IL-6 is localized in the domain previously identified as site 3 of IL-6 (Somers, W., Stahl, M., and Seehra, J. S. (1997) EMBO J. 16, 989-997), already known to be involved in interactions with gp130.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2002
• Auteurs : Eric ChassefièreJean-Jacques BerthelierJean-Loup BertauxEric QuémeraisJean-Pierre PommereauPascal RannouFrançois RaulinPatrice CollDavid CosciaA. JambonPhilippe SardaJ. C. SabrouxG. VitterA. Le PichonB. LandeauPhilippe LognonnéY. CohenSébastien VergnoleG. HulotM. MandéaJ.-F. PineauBruno BézardHorst Uwe KellerDmitry V. TitovD. BreuerK. SzegoCs. FerenczMaarten Roos-SeroteOleg KorablevV. LinkinRafael RodrigoFrederic W. TaylorA.-M. Harri
• Organismes : Laboratoire de Météorologie Dynamique (UMR 8539) Centre d'étude des environnements terrestre et planétaires Service d'aéronomie Service d'aéronomie Service d'aéronomie Service d'aéronomie Laboratoire Interuniversitaire des Systèmes Atmosphériques Laboratoire Interuniversitaire des Systèmes Atmosphériques Laboratoire Interuniversitaire des Systèmes Atmosphériques Laboratoire Magie Université Paris-Sud - Paris 11 Institut de Protection et Sûreté Nucléaire Laboratoire d'Electrochimie et de Physico-chimie des Matériaux et des Interfaces Commissariat à l'énergie atomique et aux énergies alternatives Commissariat à l'énergie atomique et aux énergies alternatives Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Institut de Physique du Globe de Paris Société ALBEDO Technologies Laboratoire d'études spatiales et d'instrumentation en astrophysique Pôle Planétologie du LESIA Max-Planck-Institut für Aeronomie Max-Planck-Institut für Aeronomie Institut für Planetologie [Münster] Hungarian Academy of Sciences Eötvös Loránd Geophysical Institute Observatório Astronómico de Lisboa Space Research Institute of the Russian Academy of Sciences Space Research Institute of the Russian Academy of Sciences Instituto de Astrofísica de Andalucía = Institute of Astrophysics of Andalusia University of Oxford Finnish Meteorological Institute
• Publié dans Advances in Space Research le 26/10/2020

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Résumé : Lavoisier mission is a joint effort of eight European countries and a technological challenge aimed at investigating the lower atmosphere and the surface of Venus. The mission consists of a descent probe and three balloons to be deployed below the cloud deck. Its main scientific objectives may be summarized as following : (i) composition of the deep atmosphere : noble gas (elemental/isotopic), molecular species (elemental/ isotopic), oxygen fugacity; vertical/horizontal/temporal variability; (ii) infrared spectroscopy and radiometry (molecular composition, radiative transfer); (iii) dynamics of the atmosphere : p, T, acceleration measurements, balloon localization through VLBI, meteorological events signed by acoustic waves, atmospheric mixing as imprinted on radioactive tracers; (iv) surface morphology and mineralogy through near infrared imaging on dayside, surface temperature through NIR imaging on nightside. Additional tentative objectives are search for (a) atmospheric electrical activity (optically, radioelectrically, acoustically), (b) crustal outgassing and/or volcanic activity : acoustic activity, horizontal/vertical distribution of radioactive tracers, (c) seismic activity : acoustic waves transmitted from crust to atmosphere, and (d) remanent and/or intrinsic magnetic field. Lavoisier was proposed to ESA in response to the F2/F3 mission Announcement of Opportunity at the beginning of 2000, but it was not selected for the assessment study. A wide international partnership was created for this occasion, including Finland (FMI), France (IPSL, MAGIE, Université Orsay, IPSN, INPG, CEA, IPGP, Obs. Paris-Meudon), Germany (MPAe, Univ. Muenster), Hungary (KFKI, Univ. Eotvos), Portugal (OAL), Russia (IKI), Spain (IAA), United Kingdom (Univ. Oxford).

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2002
• Auteurs : Philippe TalagaVirginie CogezJean-Michel WieruszeskiBernd StahlJérôme LemoineGuy LippensJean-Pierre Bohin
• Organismes : Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Synthèse, structure et fonction des biomolécules Research International Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Synthèse, structure et fonction des biomolécules Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
• Publié dans European Journal of Biochemistry le 23/10/2020

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Résumé : The osmoregulated periplasmic glucans (OPGs) produced by Rhodobacter sphaeroides, a free-living organism, were isolated by trichloracetic acid treatment and gel permeation chromatography. Compounds obtained were characterized by compositional analysis, matrix-assisted laser desorption ionization mass spectrometry and nuclear magnetic resonance. R. sphaeroides predominantly synthesizes a cyclic glucan containing 18 glucose residues that can be substituted by one to seven succinyl esters residues at the C6 position of some of the glucose residues, and by one or two acetyl residues. The glucans were subjected to a mild alkaline treatment in order to remove the succinyl and acetyl substituents, analyzed by MALDI mass spectrometry and purified by high-performance anion-exchange chromatography. Methylation analysis revealed that this glucan is linked by 17 1,2 glycosidic bonds and one 1,6 glycosidic bond. Homonuclear and 1H/13C heteronuclear NMR experiments revealed the presence of a single alpha-1,6 glycosidic linkage, whereas all other glucose residues are beta-1,2 linked. The different anomeric proton signals allowed a complete sequence-specific assignment of the glucan. The structural characteristics of this glucan are very similar to the previously described OPGs of Ralstonia solanacearum and Xanthomonas campestris, except for its different size and the presence of substituents. Therefore, similar OPGs are synthesized by phytopathogenic as well as free-living bacteria, suggesting these compounds are intrinsic components of the Gram-negative bacterial envelope

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/01/2002
• Auteurs : Philippe DessusJean-Yves Carpanèse
• Organismes : Laboratoire des Sciences de l'Éducation (Grenoble) French American School of Portland, USA Laboratoire des Sciences de l'Éducation (Grenoble)

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