Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2000
• Auteurs : René ChioléroJean-Pierre RevellyXavier Maurice LevervePhilippe GersbachMarie-Christine CayeuxMette M. BergerLuc Tappy
• Organismes : Service de médecine intensive adulte Service de médecine intensive adulte Bioénergétique fondamentale et appliquée Department of Cardiovascular Surgery Department of Adult Intensive Care Medicine and Burns Center Department of Adult Intensive Care Medicine and Burns Center Institute of Physiology
• Publié dans Critical Care Medicine le 31/10/2020

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Résumé : BACKGROUND: Hyperlactatemia is a prominent feature of cardiogenic shock. It can be attributed to increased tissue production of lactate related to dysoxia and to impaired utilization of lactate caused by liver and tissue underperfusion. The aim of this prospective observational study was to determine the relative importance of these mechanisms during cardiogenic shock. PATIENTS: Two groups of subjects were compared: seven cardiac surgery patients with postoperative cardiogenic shock and seven healthy volunteers. METHODS: Lactate metabolism was assessed by using two independent methods: a) a pharmacokinetic approach based on lactate plasma level decay after the infusion of 2.5 mmol x kg(-1) of sodium lactate; and b) an isotope dilution technique for which the transformation of [13C]lactate into [13C]glucose and 13CO2 was measured. Glucose turnover was determined using 6,62H2-glucose. RESULTS: All patients suffered from profound shock requiring high doses of inotropes and vasopressors. Mean arterial lactate amounted to 7.8 +/- 3.4 mmol x L(-1) and mean pH to 7.25 +/- 0.07. Lactate clearance was not different in the patients and controls (7.8 +/- 3.4 vs. 10.3 +/- 2.1 mL x kg(-1) x min(-1)). By contrast, lactate production was markedly enhanced in the patients (33.6 +/- 16.4 vs. 9.6 +/- 2.2 micromol x kg(-1) x min(-1); p < .01). Exogenous [13C]lactate oxidation was not different (107 +/- 37 vs. 103 +/- 4 mmol), and transformation of [13C]lactate into [13C]glucose was not different (20.0 +/- 13.7 vs. 15.2% +/- 6.0% of exogenous lactate). Endogenous glucose production was markedly increased in the patients (1.95 +/- 0.26 vs. 5.3 +/- 3.0 mg x kg(-1) x min(-1); p < .05 [10.8 +/- 1.4 vs. 29.4 +/- 16.7 micromol x kg(-1) x min(-1)]), whereas net carbohydrate oxidation was not different (1.7 +/- 0.5 vs. 1.3 +/- 0.3 mg x kg(-1) x min(-1) [9.4 +/- 2.8 vs. 7.2 +/- 1.7 micromol x kg(-1) x min(-1)]). CONCLUSIONS: Hyperlactatemia in early postoperative cardiogenic shock was mainly related to increased tissue lactate production, whereas alterations of lactate utilization played only a minor role. Patients had hyperglycemia and increased nonoxidative glucose disposal, suggesting that glucose-induced stimulation of tissue glucose uptake and glycolysis may contribute significantly to hyperlactatemia.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2000
• Auteurs : Philippe TorresPierre Lopez
• Organismes : Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes
• Publié dans European Journal of Operational Research le 22/10/2020

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Résumé : This paper is concerned with the development of constraint propagation techniques for the characterization of feasible solutions in disjunctive scheduling. In disjunctive scheduling, a set of uninterruptible tasks is to be performed on a set of resources. Each task has a release date, a deadline, and a fixed processing time; each resource can handle only one task at a time. Some of these propagation techniques are implemented by rules that deduce either mandatory or forbidden sequences between tasks or sets of tasks. For instance, certain rules indicate whether a given task must or cannot be performed before or after a set of other competing tasks. We focus our attention on the latter problem, known as the ``Not-First/Not-Last" problem. The genericity of propagation rules is a question of major importance. It induces that the result of the overall propagation must not depend on the order in which the inference rules are applied. Hence, one must search for completeness in the time-windows narrowing, in order to ensure the convergence of the propagation towards a unique fix-point. An efficient algorithm is proposed. It guarantees the completeness of time-windows narrowing due to not-first/not-last conditions. It has been integrated in a branch and bound procedure to solve job-shop instances. It has also been tested within several lower bounding procedures. Computational results are reported and the power and complementarity of not-first/not-last rules with other classical inference rules is discussed.

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Fichiers liés : papier-EJOR.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/11/2000
• Auteurs : Sébastien FévrierPhilippe RoyJean-Louis AugusteJacques MarcouDominique PagnouxJean-Marc BlondyPierre SansonettiLaurent GascaLaurent Provost
• Organismes : Institut de Recherche en Communications Optiques et Microondes Institut de Recherche en Communications Optiques et Microondes Institut de Recherche en Communications Optiques et Microondes Institut de Recherche en Communications Optiques et Microondes Institut de Recherche en Communications Optiques et Microondes Institut de Recherche en Communications Optiques et Microondes Alcatel Research & Innovation Center Alcatel Research & Innovation Center Alcatel Research & Innovation Center

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• Type de publi. : Article dans une revue
• Date de publi. : 15/11/2000
• Auteurs : Anne Harduin-LepersDavid StokesWim F. a. SteelantBénédicte Samyn-PetitMarie-Ange Krzewinski-RecchiVeronica Vallejo-RuizJean-Pierre ZanettaClaudine AugéPhilippe Delannoy
• Organismes : Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 Institut de Chimie Moléculaire et des Matériaux d'Orsay Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
• Publié dans Biochemical Journal le 28/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2000
• Auteurs : Xavier Durrieu de MadronAbderrazzak AbassiSerge HeussnerAndré MonacoJean Claude AloisiOlivier RadakovitchPierre GiresseRoselyne BuscailPhilippe Kerhervé
• Organismes : Centre de Formation et de Recherche sur les Environnements Méditérranéens Centre de formation et de recherche en environnement marin Centre de formation et de recherche en environnement marin Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Laboratoire de Sédimentologie Marine Centre de formation et de recherche en environnement marin Centre de Formation et de Recherche sur les Environnements Méditérranéens
• Publié dans Oceanologica Acta le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/11/2000
• Auteurs : M. BadilaG. BrezeanuG. DilimotJosé del R. MillánPhilippe GodignonJean-Pierre ChanteMarie-Laure LocatelliN. MestresA. A. Lebedev
• Organismes : Fac Elect Univ Politehnica Bucharest Centro Nacional de Microelectronica [Spain] Centre de génie électrique de Lyon Ampère Centre de génie électrique de Lyon Ampère
• Publié dans Microelectronics Journal le 28/10/2020

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Résumé : A refined technology of SiC p-n junctions is proposed. Usage of boron to compensate the high doping of n layers on structures with different continuous areas is primarily experimentally demonstrated. A comparison between the electrical characteristics of boron compensated and uncompensated diodes is presented. Then a technology using cellular structure for 6H-SiC large area p-n devices is designed and optimized. For these split area structures the micropipes effect is avoided. Based on a matrix structure with 0.16 mm(2) cell area a medium power (600 V breakdown voltage and 1 A at forward voltage of 5 V) p-n diode has been fabricated and tested. (C) 2000 Elsevier Science Ltd. All rights reserved.

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• Type de publi. :
• Date de publi. : 09/10/2000
• Auteurs : Catherine LabbéElisabeth BlesboisJean-Pierre BrillardJ.F. BussièresPhilippe GuillouetDominique HermierB. LeboeufMichèle MagistriniGérard MaisseMarianne Vidament
• Organismes : Station commune de Recherches en Ichtyophysiologie, Biodiversité et Environnement Station de Recherches Avicoles Station de Recherches Avicoles Insémination Caprine et Porcine Insémination Caprine et Porcine Insémination Caprine et Porcine Physiologie de la reproduction et des comportements [Nouzilly] Station commune de Recherches en Ichtyophysiologie, Biodiversité et Environnement Physiologie de la reproduction et des comportements [Nouzilly]

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• Type de publi. : Article dans une revue
• Date de publi. : 01/10/2000
• Auteurs : Christophe MorhangeJean-Philippe GoiranMichel BourcierPierre CarbonelJoël Le CampionJean-Marie RouchyMarguerite Yon
• Organismes : Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Station Marine d'Endoume Environnements et Paléoenvironnements OCéaniques Station Marine d'Endoume Paléontologie et stratigraphie Maison de l'Orient et de la Méditerranée - Jean Pouilloux
• Publié dans Marine Geology le 28/10/2020

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Résumé : Sedimentological, paleontological analysis and 14C dating of 17 cores obtained in the vicinity of the Phoenician military harbor (VIII–IV BC) of Kition Bamboula (Cyprus) provide new paleo-environmental information for the reconstruction of shoreline changes for Kition and Larnaca Bay over the last 4000 years. We propose that a communication existed between the inner harbor of Bamboula (presently 400 m inland) and the northern district of Lichines, which was a marine embayment. Our core data led us to revisit the previous hypothesis of a direct east–west channel between the harbor and the open sea (Nicolaou, K., 1976. The historical topography of Kition. Studies in Mediterranean Archaeology, Göteborg, vol. 153, pp. 1–373; Gifford, J.A., 1978. Paleogeography of archaelogical sites of the Larnaca lowlands, southeastern Cyprus. PhD Thesis, University of Minnesota, pp. 1–192). We propose instead that a spit of coarse material isolated the lagoon from the open sea from 2600 to 1600 years BP.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/09/2000
• Auteurs : François BermondPhilippe VezinMichelle RametRobert BouquetYves CaireJean-Pierre VerriestEric Voiglio
• Organismes : Laboratoire de biomécanique et mécanique des chocs Laboratoire de biomécanique et mécanique des chocs Laboratoire de biomécanique et mécanique des chocs Laboratoire de biomécanique et mécanique des chocs Laboratoire de biomécanique et mécanique des chocs Laboratoire de biomécanique et mécanique des chocs Centre Hospitalier Universitaire de Lyon

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Résumé : The information presented here show the response of the Post Mortem Human Subject in a frontal sled deceleration test which is used for the validation of the model

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• Type de publi. : Article dans une revue
• Date de publi. : 15/09/2000
• Auteurs : Philippe OhlmannAnita Eckly-MichelMonique FreundJean-Pierre CazenaveStefan OffermannsChristian Gachet
• Organismes :
• Publié dans Blood le 28/10/2020

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Résumé : Platelets from Galphaq knockout mice are unable to aggregate in response to physiological agonists like adenosine 5'-diphosphate (ADP), thromboxane A(2), thrombin, or collagen, although shape change still occurs in response to all of these agonists except ADP. ADP-induced platelet aggregation results from simultaneous activation of the purinergic P2Y(1) receptor coupled to calcium mobilization and shape change and of a distinct P2 receptor, P2cyc, coupled through Gi to adenylyl cyclase inhibition, which is responsible for completion and amplification of the response. P2cyc could be the molecular target of the antithrombotic drug clopidogrel and the adenosine triphosphate (ATP) analogs AR-C69931MX, AR-C67085, and AR-C66096. The aim of the present study was to determine whether externally added ADP could still act through the Gi pathway in Galphaq-deficient mouse platelets and thereby amplify the residual responses to agonists such as thrombin or collagen. It was found that (1) ADP and adrenaline still inhibited cyclic AMP accumulation in Galphaq-deficient platelets; (2) both agonists restored collagen- but not thrombin-induced aggregation in these platelets; (3) the effects of ADP were selectively inhibited in vitro by the ATP analog AR-C69931MX and ex vivo by clopidogrel and hence were apparently mediated by the P2cyc receptor; and (4) high concentrations of ADP (100 micromol/L) induced aggregation without shape change in Galphaq-deficient platelets through activation of P2cyc. Since adrenaline was not able to induce platelet aggregation even at high concentrations, we conclude that the effects of ADP mediated by P2cyc are not restricted to the inhibition of adenylyl cyclase through Gi(2).

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