Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 26/04/2001
• Auteurs : Philippe BlancouJean Pierre VartanianCindy ChristophersonNicole ChencinerClaudio BasilicoShirley KwokSimon Wain-Hobson
• Organismes : Rétrovirologie Moléculaire Rétrovirologie Moléculaire Roche Molecular Systems Rétrovirologie Moléculaire New York University School of Medicine Roche Molecular Systems Rétrovirologie Moléculaire
• Publié dans Nature le 29/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 20/04/2001
• Auteurs : Crystel BonnetDominique BoucherSylvie LazeregBarbara PedrottiKhalid IslamPhilippe DenouletJean-Christophe Larcher
• Organismes : Biochimie cellulaire : relations cycle cellulaire, cytosquelette et traduction Biochimie cellulaire : relations cycle cellulaire, cytosquelette et traduction Biochimie cellulaire : relations cycle cellulaire, cytosquelette et traduction Università degli Studi di Milano = University of Milan Arpida AG Biochimie cellulaire : relations cycle cellulaire, cytosquelette et traduction Biochimie cellulaire : relations cycle cellulaire, cytosquelette et traduction
• Publié dans Journal of Biological Chemistry le 02/11/2020

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Résumé : The major neuronal post-translational modification of tubulin, polyglutamylation, can act as a molecular potentiometer to modulate microtubule-associated proteins (MAPs) binding as a function of the polyglutamyl chain length. The relative affinity of Tau, MAP2, and kinesin has been shown to be optimal for tubulin modified by approximately 3 glutamyl units. Using blot overlay assays, we have tested the ability of polyglutamylation to modulate the interaction of two other structural MAPs, MAP1A and MAP1B, with tubulin. MAP1A and MAP2 display distinct behavior in terms of tubulin binding; they do not compete with each other, even when the polyglutamyl chains of tubulin are removed, indicating that they have distinct binding sites on tubulin. Binding of MAP1A and MAP1B to tubulin is also controlled by polyglutamylation and, although the modulation of MAP1B binding resembles that of MAP2, we found that polyglutamylation can exert a different mode of regulation toward MAP1A. Interestingly, although the affinity of the other MAPs tested so far decreases sharply for tubulins carrying long polyglutamyl chains, the affinity of MAP1A for these tubulins is maintained at a significant level. This differential regulation exerted by polyglutamylation toward different MAPs might facilitate their selective recruitment into distinct microtubule populations, hence modulating their functional properties.

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Fichiers liés : 1-s2.0-S0021925819343935-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2001
• Auteurs : Philippe CouvertThierry BienvenuCecile AquavivaKarine PoirierClaude MoraineChantal GendrotAlain VerloesChristian AndrèsAnne Celine Le FevreIsabelle SouvilleJulie SteffannVincent Des PortesHans-Hilger RopersHelger G. YntemaJean-Pierre FrynsSylvain BriaultJamel ChellyBeldjord Cherif
• Organismes : Hôpital Cochin [AP-HP] Institut Cochin Hôpital Cochin [AP-HP] Institut Cochin Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Institut Cochin Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Universitaire Sart Tilman Centre Hospitalier Régional Universitaire de Tours Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Institut Cochin Max Planck Institute for Molecular Genetics Nijmegen Medical Centre [Nijmegen] Universitair Ziekenhuis Leuven = University Hospital of Leuven = Hopital universitaire de Louvain Centre Hospitalier Régional Universitaire de Tours Hôpital Cochin [AP-HP] Institut Cochin Hôpital Cochin [AP-HP] Institut Cochin
• Publié dans Human Molecular Genetics le 26/10/2020

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Résumé : Following the recent discovery that the methyl-CpG binding protein 2 (MECP2) gene located on Xq28 is involved in Rett syndrome (RTT), a wild spectrum of phenotypes, including mental handicap, has been shown to be associated with mutations in MECP2. These findings, with the compelling genetic evidence suggesting the presence in Xq28 of additional genes besides RabGDI1 and FMR2 involved in non-specific X-linked mental retardation (MRX), prompted us to investigate MECP2 in MRX families. Two novel mutations, not found in RTT, were identified. The first mutation, an E137G, was identified in the MRX16 family, and the second, R167W, was identified in a new mental retardation (MR) family shown to be linked to Xq28. In view of these data, we screened MECP2 in a cohort of 185 patients found negative for the expansions across the FRAXA CGG repeat and reported the identification of mutations in four sporadic cases of MR. One of the mutations, A140V, which we found in two patients, has been described previously, whereas the two others, P399L and R453Q, are novel mutations. In addition to the results demonstrating the involvement of MECP2 in MRX, this study shows that the frequency of mutations in MECP2 in the mentally retarded population screened for the fragile X syndrome is comparable to the frequency of the CGG expansions in FMR1. Therefore, implementation of systematic screening of MECP2 in MR patients should result in significant progress in the field of molecular diagnosis and genetic counseling of mental handicap.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/04/2001
• Auteurs : Pierre FriedlingsteinLaurent BoppPhilippe CiaisJean-Louis DufresneLaurent FairheadHervé LetreutPatrick MonfrayJames Orr
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-ATC Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire de Météorologie Dynamique (UMR 8539) Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette]
• Publié dans Geophysical Research Letters le 25/10/2020

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Résumé : Future climate change due to increased atmospheric CO2 may affect land and ocean efficiency to absorb atmospheric CO2. Here, using climate and carbon three-dimensional models forced by a 1% per year increase in atmospheric CO•, we show that there is a positive feedback between the climate system and the carbon cycle. Climate change reduces land and ocean uptake of CO•, respectively by 54% and 35% at 4 x CO•. This negative impact implies that for prescribed anthropogenic COy. emissions, the atmospheric CO• would be higher than the level reached if climate change does not affect the carbon cycle. We estimate the gain of this climate-carbon cycle feedback to be 10% at 2 x CO2 and 20% at 4 x CO•. This translates into a 15% higher mean temperature increase.

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Fichiers liés : 2000GL012015.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 12/04/2001
• Auteurs : Jean-Pierre BarthélemyPhilippe Lenca
• Organismes : Département Logique des Usages, Sciences sociales et Sciences de l'Information Département Logique des Usages, Sciences sociales et Sciences de l'Information

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Résumé : A mathematical approach for human centered decision aid

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• Type de publi. : Communication dans un congrès
• Date de publi. : 01/04/2001
• Auteurs : Erica de VriesJean-Philippe PerninJean-Pierre Peyrin
• Organismes : Laboratoire des Sciences de l'Éducation (Grenoble) Communication Langagière et Interaction Personne-Système Université Joseph Fourier - Grenoble 1

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Résumé : Ce dépôt du cinquième colloque "Hypermédias et Apprentissages" donne accès aux parties suivantes des actes : pages de couverture, comités, table des matières, introduction des organisateurs, résumés des démonstrations et ateliers, conclusions et index des auteurs. Les articles longs et courts sont déposés individuellement.

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Fichiers liés : HyperAp5p383.pdf HyperAp5p000.pdf HyperAp5p341.pdf HyperAp5p353.pdf HyperAp5p359.pdf HyperAp5p373.pdf HyperAp5p376.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2001
• Auteurs : Jean‐françois CantaloubePierre GallianHoussam AttouiPhilippe BiaginiPhilippe de MiccoXavier de Lamballerie
• Organismes : Virologie UMR1161
• Publié dans Transfusion le 25/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/03/2001
• Auteurs : Jean-Philippe JayIoan-Sorin JurcaGeneviève PourroyNathalie ViartChristian MenyPierre Panissod
• Organismes : Institut de Physique et Chimie des Matériaux de Strasbourg Institut de Physique et Chimie des Matériaux de Strasbourg Institut de Physique et Chimie des Matériaux de Strasbourg Institut de Physique et Chimie des Matériaux de Strasbourg Institut de Physique et Chimie des Matériaux de Strasbourg Institut de Physique et Chimie des Matériaux de Strasbourg
• Publié dans Solid State Sciences le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2001
• Auteurs : Corinne Martinella-CatusseMyriam PoletteAgnès NoelChristine GillesPierre DehanCarine MunautAlain ColigeLaurette VoldersJean-Claude MonboisseJean-Michel FoidartPhilippe L. Birembaut
• Organismes : Dynamique cellulaire et moléculaire de la muqueuse respiratoire Dynamique cellulaire et moléculaire de la muqueuse respiratoire Laboratory of Tumor and Developmental Biology Biomolécules : interactions moléculaires, cellulaires et cellules-matrice extracellulaire Laboratory of Tumor and Developmental Biology Biomolécules : interactions moléculaires, cellulaires et cellules-matrice extracellulaire Laboratory of Tumor and Developmental Biology Biomolécules : interactions moléculaires, cellulaires et cellules-matrice extracellulaire Laboratory of Tumor and Developmental Biology Biomolécules : interactions moléculaires, cellulaires et cellules-matrice extracellulaire Laboratory of Tumor and Developmental Biology Biomolécules : interactions moléculaires, cellulaires et cellules-matrice extracellulaire Laboratory of Tumor and Developmental Biology Biomolécules : interactions moléculaires, cellulaires et cellules-matrice extracellulaire Laboratoire d'histologie, cytologie, biologie cellulaire et moléculaire Pol Bouin Laboratory of Tumor and Developmental Biology Biomolécules : interactions moléculaires, cellulaires et cellules-matrice extracellulaire Dynamique cellulaire et moléculaire de la muqueuse respiratoire
• Publié dans Laboratory Investigation le 27/10/2020

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Résumé : The basement membrane (BM) is the first barrier encountered by tumor cells when they become invasive. Moreover, some invasive tumor clusters are surrounded by a remnant or neosynthetized BM material. We have previously reported the presence of a particular alpha chain of type IV collagen, the alpha3(IV) chain, in bronchopulmonary carcinomas. This chain was not detected in the normal bronchial epithelium, but was found around some invasive tumor cluster BM. In the present study, we examined the effects of the alpha3(IV) chain on the invasive properties of bronchial tumor cell lines, with special emphasis on their expression of matrix metalloproteinase-2 (MMP-2) and its activator, membrane type 1-matrix metalloproteinase (MT1-MMP), which is largely involved in tumor progression. Two epithelial bronchial cell lines (16HBE14o- and BZR), showing different invasive abilities, were evaluated. Using the Boyden chamber invasion assay, we demonstrated that the alpha3(IV) chain inhibits the invasive properties of BZR cells and modifies their morphology by inducing an epithelial cell shape. In the presence of the recombinant NC1 domain of the alpha3(IV) chain, the expression of MMP-2 and tissue inhibitor of metalloproteinase-2 (TIMP-2) was not modified in either cell line. The NC1 alpha3(IV) domain did not modulate the MT1-MMP expression of noninvasive 16HBE14o- cells, whereas a 50% decrease of MT1-MMP mRNA was observed in invasive BZR cells. Accordingly, Western blot analyses showed a disappearance of the 45-kd MT1-MMP form when BZR cells were treated with the recombinant NC1 alpha3(IV) domain. These findings suggest that the alpha3 chain of type IV collagen may play a role in tumor invasion, at least by decreasing the expression and synthesis of MT1-MMP.

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Fichiers liés : Marinella-Catusse_20C_202001.pdf inserm-00153423_edited.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2001
• Auteurs : Bruno CogniePhilippe RosaVona MéléderAnne-Laure BarilléJean-Pierre BaudLaurent Barillé
• Organismes : Laboratoire de biologie marine Laboratoire de biologie marine Laboratoire de biologie marine Laboratoire de biologie marine Institut Français de Recherche pour l'Exploitation de la Mer Laboratoire de biologie marine
• Publié dans Aquatic Living Resources le 27/10/2020

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Résumé :

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