Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1993
• Auteurs : Jean-Pierre BenitahAna Maria GómezPatrick BaillyJean-Philippe da PonteGuy BersonCarmen DelgadoPaco Lorente
• Organismes : Service Pharmacologie Médicale [CHU Clermont-Ferrand] Service Pharmacologie Médicale [CHU Clermont-Ferrand] Service Pharmacologie Médicale [CHU Clermont-Ferrand] Service Pharmacologie Médicale [CHU Clermont-Ferrand] Service Pharmacologie Médicale [CHU Clermont-Ferrand] Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] Consejo Superior de Investigaciones Cientificas [España] = Spanish National Research Council [Spain] Service Pharmacologie Médicale [CHU Clermont-Ferrand]
• Publié dans American Journal of Physiology le 29/10/2020

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Résumé : 1. The nature, magnitude and kinetics of the 4-aminopyridine-sensitive early outward current (Ito) were analysed in isolated ventricular myocytes from the septum, the apex and the left ventricular free wall of rat ventricles using the whole-cell voltage clamp method. The modulatory effect of pressure overload-induced cardiac hypertrophy on the regional variations of Ito was assessed in each topographical class of cells. 2. Voltage clamp experiments were performed at room temperature (20-25°C) in the absence of Na+ on both sides of the membrane and in the presence of 3 mM CoCl2. Ito was studied from a holding potential of-80 mV and determined by subtraction of total outward currents elicited by the same protocols in the presence of 3 mm 4-aminopyridine (4-AP) from those obtained in its absence. 3. In normal hearts, membrane passive properties were very similar in each topographical class of cells. Our results confirmed that the predominant early outward current in rat ventricular cells was 4-AP-sensitive, time and voltage dependent, and demonstrated that the magnitude of the current varied on a regional basis: current density of Ito in left ventricular free wall cells (30-1 +9-2 pA/pF at + 60 mV) was larger than in apex cells (20-2 + 1-7 pA/pF) or in septum cells (1 1-9 + 3-3 pA/pF). We noticed a larger variability in data from left ventricular free wall compared with other regions. 4. No shift in steady-state voltage dependence of Ito activation and inactivation was found. However, the maximal computed chord conductances were (in ,uS/pF): 0 18 + 0-07 for left ventricular free wall cells, 0-13 + 0-02 for apex cells, and 0-08 + 0-02 for septum cells. These findings might reflect a differential distribution in functional channel densities. 5. No difference in voltage-dependent Ito activation kinetics was present with respect to topography. However, inactivation time constants in septum were longer than those of both other groups. 6. Left ventricular hypertrophy was induced by abdominal aortic constriction and MS 1562

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Fichiers liés : 1993JPhysiol.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1993
• Auteurs : Henri BougaultJean-Luc CharlouYves FouquetHubert NeedhamNathalie VasletPierre AppriouPhilippe Jean BaptistePeter RonaLeonid DmitrievSergei Silantiev
• Organismes : Institut Français de Recherche pour l'Exploitation de la Mer Laboratoire de Modélisation du Climat et de l'Environnement
• Publié dans Journal of Geophysical Research le 01/11/2020

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Fichiers liés : jgr1993Bougault9643.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1993
• Auteurs : Didier A SchmittPhilippe OhlmannChristian GachetJean-Pierre Cazenave
• Organismes :
• Publié dans Journal of Cell Science le 11/03/2022

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Résumé : Recent experiments have shown that the stimulation of animal cells in vitro by direct protein kinase C (PKC) activators is significantly reduced under microgravity (micro g). Platelets undergo protein phosphorylation and morphological changes a few seconds after stimulation by agonists such as phorbol esters which activate PKC. Therefore, taking advantage of parabolic plane flight to obtain short periods of microgravity, we studied phosphorylation of myosin light chain (20K), specific PKC-dependent phosphorylation of a 40,000 M(r) protein, pleckstrin (40K) and platelet shape change. SDS-PAGE analysis and electron microscopy were performed on platelets subjected to 20 seconds microgravity as compared to normal gravity (1 g) conditions. These investigations showed that neither Ca(2+)-calmodulin-mediated activation nor the PKC-dependent pathways are inhibited during short periods of microgravity.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/1993
• Auteurs : C. Klein-SoyerJean-Philippe MazzucotelliAlain BeretzGisele Haan-ArchipoffC. BrissonJean-Pierre Cazenave
• Organismes : Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1993
• Auteurs : Jean Claude GuilleminJean Luc CabiochXavier MoriseJean Marc DenisSylvie Lacombe-LhosteDanielle GonbeauGenevieve Pfister-GuillouzoPierre GuenotPhilippe Savignac
• Organismes : Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux
• Publié dans Inorganic Chemistry le 31/10/2020

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Résumé : The present work is devoted to the preparation of unsubstituted 1- and 2-phosphabutadienes. 2-Phosphadiene 3a is formed by HCl-elimination of the (chloromethyl)vinylphosphine 8 and 1-phosphadienes 1 by 1,4-dehydrochlorination of the corresponding (chloroallyl)phosphine 13a (1a) and by FVT of diallylphosphines 15a,b via a retro-ene reaction (1a,b). All the dehydrohalogenations occurred either in solution at low temperature with a Lewis base or in the gas phase (VGSR). Whichever the method used, only the opened structures 1a,b and 3a have been observed both in solution as well as in the gas-phase. 2-Phosphabutadiene 3a has been unambiguously characterized in solution by 1H and 31P NMR. Adducts of 1a and 3a were isolated when 2-propanethiol was introduced either with the Lewis base and chlorophosphine precursors 8 and 13a or with the condensed products from the VGSR and FVT apparatus (vacuum gas-phase dehydrochlorination of 8 and 13a and thermolysis of the diallylphosphine 15a). Other structural evidence for 1a,b and 3a has been given by coupling the VGSR or FVT apparatus with the IR, MS, and PE spectrometers. In particular, the PE spectra of the opened chains 1a and 3a have been qualitatively estimated (Koopman's approximation and direct calculation (CIPSI)). These results are consistent with the experimental IP values [9.28 eV (πCP - πCP), 9.96 eV (nP), 11.14 eV (πCP + πCP) for 3a, 9.00 eV (πCP - πCP), 10.13 eV (nP), 11.47 eV (πCP + πCP) for 1a]. The possibility of ring closure of 1a and 3a to dihydrophosphetes 2a and 4a is discussed.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/1993
• Auteurs : Raja ChatilaRachid AlamiBernard DegallaixVictor PérébaskinePaul GaboritPhilippe Moutarlier
• Organismes : Institut des Systèmes Intelligents et de Robotique Équipe Robotique et InteractionS Équipe Robotique et InteractionS Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes Laboratoire d'analyse et d'architecture des systèmes

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• Type de publi. : Rapport
• Date de publi. : 01/01/1993
• Auteurs : Jean-Pierre ParisGérard BerryFrédéric MignardPhilippe CouronnéPaul CaspiNicolas HalbwachsYves SorelAlbert BenvenisteThierry GautierPaul Le GuernicFrançois DupontClaude Le Maire
• Organismes : CISI Ingénierie [Valbonne] École des Mines de Paris École des Mines de Paris ILOG SA [Gentilly] Institut de Mathématiques Appliquées de Grenoble [Grenoble] Institut de Mathématiques Appliquées de Grenoble [Grenoble] Models and methods of analysis and optimization for systems with real-time and embedding constraints Environnement de programmation d'applications temps réel Environnement de programmation d'applications temps réel Environnement de programmation d'applications temps réel TNI [Brest] Verilog [Montbonnot]

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Résumé : Ce document définit la syntaxe et la sémantique des formats communs des langages synchrones. Ces formats constituent un socle commun à la programmation synchrone, sur lequel de nombreux outils seront applicables. Le socle est constitué de trois formats entre lesquels existeront des passerelles de traduction : IC est un format parallèle de type impératif - GC est un format parallèle de type flot de données - OC est un format automate séquentiel.

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Fichiers liés : RT-0157.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1993
• Auteurs : Ulla B. RasmussenChristian GachetYasmin SchlesingerDaniel HanauPhilippe OhlmannEllen van Obberghen-SchillingJacques PouyssegurJean-Pierre CazenaveAndrea Pavirani
• Organismes : Transgene SA Biologie et pharmacologie de l'hémostase et de la thrombose Transgene SA Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Biologie et pharmacologie de l'hémostase et de la thrombose Transgene SA
• Publié dans Journal of Biological Chemistry le 02/11/2020

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Résumé : The peptide YFLLRNP antagonizes the aggregation of human platelets when induced by low concentrations of alpha-thrombin or the thrombin receptor agonist peptide (SFLLRNP), demonstrating that it interacts specifically with the thrombin receptor. Platelets exposed to YFLLRNP show immediate shape change (pseudopod formation) and potentiation of the ADP and platelet-activating factor response, but no Ca2+ mobilization, P47 (pleckstrin) phosphorylation, secretion, or aggregation. Thus, YFLLRNP induces a state of partial activation of the platelets. Furthermore, with platelets prestimulated with adrenalin (10 microM), YFLLRNP induces aggregation, but no secretion, and only in the presence of added fibrinogen. We also found that prostacyclin inhibits the YFLLRNP-induced shape change; but EDTA, aspirin, and apyrase (ADP scavenger) do not. Thus, the thrombin receptor in platelets may communicate, independently of Ca2+ mobilization and P47 phosphorylation (protein kinase C activation), with intracellular signaling mechanisms that 1) modulate the cytoskeleton structure, 2) potentiate other platelet responses, and 3) stimulate coupling between the thrombin receptor and fibrinogen binding (the glycoprotein IIb-IIIa complex). YFLLRNP may be useful for differentiating between several possible activation states of the platelet thrombin receptor.

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Fichiers liés : islandora_90678.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/1993
• Auteurs : Jean-Loup FlouestJean-Paul GuillaumetPhilippe BarralPatrice BeckOlivier BuchsenschutzPierre-Paul BonenfantFrancois BoyerVajk CsermenyAlain DuvalJose-Maria Jean Gran-AymerichKatherine GruelAlfred HaffnerAntoinette HesnardAlbert HessePaquita HermandezJozsef LaszlovskyClaude-Alain ParatteDaniel PaunierMichel PernodIan B. M. RalstonHerve RichardMiklos SzabóDaniele Vitali
• Organismes : Archéologies, Cultures et Sociétés Laboratoire Chrono-environnement (UMR 6249) Archéologie et Philologie d'Orient et d'Occident Université libre de Bruxelles = Free University of Brussels Université Pierre et Marie Curie - Paris 6 szombathely museum Musée des Antiquités Nationales Archéologie et Philologie d'Orient et d'Occident Archéologie et Philologie d'Orient et d'Occident Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel Centre Camille Jullian - Histoire et archéologie de la Méditerranée et de l'Afrique du Nord de la protohistoire à la fin de l'Antiquité Centre de Recherches Géophysiques Eötvös Loránd Tudományegyetem = Eötvös Loránd University [Budapest] Université de Lausanne = University of Lausanne Université de Lausanne = University of Lausanne Archéologies, Cultures et Sociétés The University of Edinburgh Laboratoire de chrono-écologie - CNRS (UMR6565) Eötvös Loránd Tudományegyetem = Eötvös Loránd University [Budapest] Université Bourgogne Franche-Comté [COMUE]
• Publié dans Revue archéologique de l'Est et du Centre-Est le 04/10/2021

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Fichiers liés : B1991_1990_Chronique.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/1992
• Auteurs : Philippe GaléraDenis VivienStéphane PronostJacky BonaventureFrançoise RédiniGérard LoyauJean-Pierre Pujol
• Organismes : Laboratoire de Biochimie du tissu conjonctif Laboratoire de Biochimie du tissu conjonctif Laboratoire de Biochimie du tissu conjonctif Laboratoire de Biochimie du tissu conjonctif Laboratoire de Biochimie du tissu conjonctif
• Publié dans Journal of Cellular Physiology le 02/11/2020

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