Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 22/01/2024
• Auteurs : Thais RosanStephen SitchMichael O’sullivanLuana S BassoChristopher WilsonCamila SilvaEmanuel GloorDominic FawcettViola HeinrichJefferson G SouzaFrancisco Gilney Silva BezerraCelso von RandowLina M MercadoLuciana Vanni GattiAndy WiltshirePierre FriedlingsteinJulia PongratzClemens SchwingshacklMathew WilliamsLuke SmallmanJürgen KnauerVivek AroraDaniel KennedyHanqin TianWenping YuanAtul JainStefanie FalkBenjamin PoulterAlmut ArnethQing SunSönke ZaehleAnthony P WalkerEtsushi KatoXu YueAna BastosPhilippe CiaisWigneron J.-P.Clement AlbergelLuiz E O C Aragão
• Organismes : University of Exeter University of Exeter University of Exeter University of Leeds Instituto Nacional de Pesquisas Espaciais [Sao José dos Campos, Brasil] = National Institute for Space Research [Sao José dos Campos, Brazil] University of Leeds Lancaster University University of Leeds University of Exeter University of Exeter University of Exeter Instituto Nacional de Pesquisas Espaciais [Sao José dos Campos, Brasil] = National Institute for Space Research [Sao José dos Campos, Brazil] Instituto Nacional de Pesquisas Espaciais [Sao José dos Campos, Brasil] = National Institute for Space Research [Sao José dos Campos, Brazil] University of Exeter Instituto Nacional de Pesquisas Espaciais [Sao José dos Campos, Brasil] = National Institute for Space Research [Sao José dos Campos, Brazil] University of Exeter University of Exeter Fakultät für Physik - Ludwig-Maximilians-Universität [München/Munich] Fakultät für Physik - Ludwig-Maximilians-Universität [München/Munich] The University of Edinburgh The University of Edinburgh Western Sydney University Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère
• Publié dans Communications Earth & Environment le 27/10/2020

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Résumé : The Amazon is the largest continuous tropical forest in the world and plays a key role in the global carbon cycle. Human-induced disturbances and climate change have impacted the Amazon carbon balance. Here we conduct a comprehensive synthesis of existing state-ofthe-art estimates of the contemporary land carbon fluxes in the Amazon using a set of bottom-up methods (i.e., dynamic vegetation models and bookkeeping models) and a topdown inversion (atmospheric inversion model) over the Brazilian Amazon and the whole Biogeographical Amazon domain. Over the whole biogeographical Amazon region bottom-up methodologies suggest a small average carbon sink over 2010-2020, in contrast to a small carbon source simulated by top-down inversion (2010-2018). However, these estimates are not significantly different from one another when accounting for their large individual uncertainties, highlighting remaining knowledge gaps, and the urgent need to reduce such uncertainties. Nevertheless, both methodologies agreed that the Brazilian Amazon has been a net carbon source during recent climate extremes and that the southeastern Amazon was a net land carbon source over the whole study period (2010-2020). Overall, our results point to increasing human-induced disturbances (deforestation and forest degradation by wildfires) and reduction in the old-growth forest sink during drought.

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Fichiers liés : s43247-024-01205-0.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/01/2024
• Auteurs : Karine LambouAndrew TagAlexandre LassagneJérôme CollemarePierre-Henri ClergeotCrystel BarbisanPhilippe PerretDidier TharreauJoelle MillazoElia ChartierRonald de VriesJudith HirschJean Benoît MorelRoland BeffaThomas KrojTerry ThomasMarc-Henri Lebrun
• Organismes : Microbiologie, adaptation et pathogénie Plant Health Institute of Montpellier Texas A&M University System Plant Health Institute of Montpellier Microbiologie, adaptation et pathogénie Westerdijk Fungal Biodiversity Institute [Utrecht] Microbiologie, adaptation et pathogénie Bayer CropScience [UK] Bayer CropScience [UK] Plant Health Institute of Montpellier Département Systèmes Biologiques Plant Health Institute of Montpellier Plant Health Institute of Montpellier Westerdijk Fungal Biodiversity Institute [Utrecht] Plant Health Institute of Montpellier Unité de Pathologie Végétale Plant Health Institute of Montpellier Bayer CropScience [UK] Plant Health Institute of Montpellier Texas A&M University System BIOlogie et GEstion des Risques en agriculture Génomique fonctionnelle des Champignons Phytopathogènes Microbiologie, adaptation et pathogénie
• Publié dans PLoS Pathogens le 27/10/2020

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Résumé : The rice blast fungus Magnaporthe oryzae differentiates specialized cells called appressoria that are required for fungal penetration into host leaves. In this study, we identified the novel basic leucine zipper (bZIP) transcription factor BIP1 ( B -ZIP I nvolved in P athogenesis- 1 ) that is essential for pathogenicity. BIP1 is required for the infection of plant leaves, even if they are wounded, but not for appressorium-mediated penetration of artificial cellophane membranes. This phenotype suggests that BIP1 is not implicated in the differentiation of the penetration peg but is necessary for the initial establishment of the fungus within plant cells. BIP1 expression was restricted to the appressorium by both transcriptional and post-transcriptional control. Genome-wide transcriptome analysis showed that 40 genes were down regulated in a BIP1 deletion mutant. Most of these genes were specifically expressed in the appressorium. They encode proteins with pathogenesis-related functions such as enzymes involved in secondary metabolism including those encoded by the ACE1 gene cluster, small secreted proteins such as SLP2, BAS3, BAS4, and AVR-Pi9 effectors, as well as plant cuticle and cell wall degrading enzymes. Interestingly, this BIP1 network is different from other known infection-related regulatory networks, highlighting the complexity of gene expression control during plant-fungal interactions. Promoters of BIP1 -regulated genes shared a GCN4/bZIP-binding DNA motif (TGACTC) binding in vitro to BIP1. Mutation of this motif in the promoter of MGG_08381 . 7 from the ACE1 gene cluster abolished its appressorium-specific expression, showing that BIP1 behaves as a transcriptional activator. In summary, our findings demonstrate that BIP1 is critical for the expression of early invasion-related genes in appressoria. These genes are likely needed for biotrophic invasion of the first infected host cell, but not for the penetration process itself. Through these mechanisms, the blast fungus strategically anticipates the host plant environment and responses during appressorium-mediated penetration.

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Fichiers liés : journal.ppat.1011945.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/01/2024
• Auteurs : Laurène Meyniel-SchicklinJérôme AmaudrutPierre MallinjoudFabrice GuillierPhilippe-Emmanuel MangeotLaetitia LinesAnne Aublin-GexCaroline ScholtesClaire PunginelliStéphane JolyFlorence VasseurEvelyne ManetHenri GruffatHenry ThomasFarès HalitimJean-Laurent PaparinPeter MachinRaphaël DarteilDiane SampsonIvan MikaelianLydie LaneVincent NavratilMarie-Pierre GolinelliFabiola TerziPatrice AndréVincent LotteauJacky VonderscherEric C MeldrumBenoit de Chassey
• Organismes : ENYO Pharma SAS Inventiva, Daix 21121, France Centre de Recherche en Cancérologie de Lyon Institut Gilbert-Laustriat : Biomolécules, Biotechnologie, Innovation Thérapeutique Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] ENYO Pharma SAS Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] Hospices Civils de Lyon Hôpital de la Croix-Rousse [CHU - HCL] Laboratoire de Virologie [HCL-Hôpital de la Croix Rousse] Université Claude Bernard Lyon 1 Centre de Recherche en Cancérologie de Lyon Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] ENYO Pharma SAS Institut Necker Enfants-Malades Centre International de Recherche en Infectiologie Centre International de Recherche en Infectiologie Expression de l'ARN chez les virus et les eucaryotes - RNA Expression in Viruses and Eukaryotes [CIRI] Centre International de Recherche en Infectiologie Inflammasome, Infections bactériennes et autoinflammation ; Inflammasome, Bacterial Infections and Autoinflammation [CIRI] ENYO Pharma SAS IDENIX ENYO Pharma SAS ENYO Pharma SAS ENYO Pharma SAS Centre de Recherche en Cancérologie de Lyon Université de Genève = University of Geneva Pôle Rhône-Alpin de BioInformatique [Lyon] Institut de Chimie des Substances Naturelles Institut Necker Enfants-Malades Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] Infection virale, métabolisme et immunité - Viral Infection, Metabolism and Immunity [CIRI] ENYO Pharma SAS ENYO Pharma SAS ENYO Pharma SAS
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : Significance Viruses have designed small protein interfaces to interact with human proteins. These viral peptides are original molecules to modulate the activity of host targets and an inspiration to create original drugs. Here, the wealth of virus-host protein interactions existing in the literature is integrated in an substantial database. A sample peptide library is screened against several pathogens, highlighting peptides modulators of replication. From one of them, a drug discovery program identifies highly potent antiviral molecules interacting with human metabolic targets. These molecules are proven to be active for treatment of mouse model of nonalcoholic steatohepatitis with chronic kidney disease. Our approach validates an original biomimetic framework to address cellular functions for fundamental applications and drug discovery.

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Fichiers liés : meyniel-schicklin-et-al-2024-viruses-traverse-the-human-proteome-through-peptide-interfaces-that-can-be-biomimetically.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 18/01/2024
• Auteurs : Ambre GuilloryMauricio Lopez-ObandoKhalissa BoucheninePhilippe Le BrisAlain LécureuilJean-Paul PillotVincent SteinmetzFrançois-Didier BoyerCatherine RameauAlexandre de Saint GermainSandrine Bonhomme
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Laboratoire des Interactions Plantes Microbes Environnement Institut Jean-Pierre Bourgin - Sciences du végétal Institut de Biologie Moléculaire des Plantes Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut de Chimie des Substances Naturelles Institut de Chimie des Substances Naturelles Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans The Plant cell le 27/10/2020

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Résumé : SUPPRESSOR OF MAX2 (SMAX)1-LIKE (SMXL) proteins are a plant-specific clade of type I HSP100/Clp-ATPases. SMXL genes are present in virtually all land plant genomes. However, they have mainly been studied in angiosperms. In Arabidopsis (Arabidopsis thaliana), 3 functional SMXL subclades have been identified: SMAX1/SMXL2, SMXL345, and SMXL678. Of these, 2 subclades ensure endogenous phytohormone signal transduction. SMAX1/SMXL2 proteins are involved in KAI2 ligand (KL) signaling, while SMXL678 proteins are involved in strigolactone (SL) signaling. Many questions remain regarding the mode of action of these proteins, as well as their ancestral roles. We addressed these questions by investigating the functions of the 4 SMXL genes in the moss Physcomitrium patens. We demonstrate that PpSMXL proteins are involved in the conserved ancestral MAX2-dependent KL signaling pathway and negatively regulate growth. However, PpSMXL proteins expressed in Arabidopsis cannot replace SMAX1 or SMXL2 function in KL signaling, whereas they can functionally replace SMXL4 and SMXL5 and restore root growth. Therefore, the molecular functions of SMXL proteins are conserved, but their interaction networks are not. Moreover, the PpSMXLC/D clade positively regulates SL signal transduction in P. patens. Overall, our data reveal that SMXL proteins in moss mediate crosstalk between the SL and KL signaling pathways.

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Fichiers liés : TPC2023-RA-00618DR2_TPC2023-RA-00618DR2_Manuscript-Merged.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 17/01/2024
• Auteurs : Achim J KaaschLuis Eduardo López-CortésJesus Rodriguez-BanoJose Miguel Cisneros HerrerosM Dolores NavarroGerd FätkenheuerNorma JungSiegbert RiegOlivier ChosidowLaetitia CoutteLouis BernardAdrien LemaignenKatrin KöstersColin R MackenzieAlex SorianoStefan HagelBruno FantinMatthieu LafaurieJean-Philippe TalarminAurelien DinhThomas GuimardDavid BoutoilleTobias WelteStefan ReuterJan KluytmansMaria Luisa MartinEmmanuel ForestierHartmut StöckerVirginie VitratPierre TattevinAnna RommerskirchenMarion NoretAnne AdamsWinfried V. KernMartin HellmichHarald Seifert
• Organismes : Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg] Hospital Universitario Virgen Macarena [Séville] Hospital Universitario Virgen Macarena [Séville] Hospital Universitario Virgen del Rocío [Sevilla] Universidad de Sevilla = University of Seville = Université de Seville Hospital Universitario Virgen del Rocío [Sevilla] Universität zu Köln = University of Cologne Universitäts Klinikum Freiburg = University Medical Center Freiburg Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours University Hospital Düsseldorf Centro de Investigación Biomédica en Red de Enfermedades Infecciosas Hôpital Beaujon [AP-HP] Centre Hospitalier Intercommunal de Cornouaille Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre d’Investigation Clinique de Nantes Medizinische Hochschule Hannover = Hannover Medical School University Medical Center [Utrecht] Fundació Institut d'Investigació Sanitària Illes Balears Centre Hospitalier Métropole Savoie [Chambéry] ARN bactériens et médecine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] University Hospital Düsseldorf Universität zu Köln = University of Cologne
• Publié dans The Lancet Infectious Diseases le 29/10/2020

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Résumé : BACKGROUND: Staphylococcus aureus bloodstream infection is treated with at least 14 days of intravenous antimicrobials. We assessed the efficacy and safety of an early switch to oral therapy in patients at low risk for complications related to S aureus bloodstream infection. METHODS: In this international, open-label, randomised, controlled, non-inferiority trial done in 31 tertiary care hospitals in Germany, France, the Netherlands, and Spain, adult patients with low-risk S aureus bloodstream infection were randomly assigned after 5-7 days of intravenous antimicrobial therapy to oral antimicrobial therapy or to continue intravenous standard therapy. Randomisation was done via a central web-based system, using permuted blocks of varying length, and stratified by study centre. The main exclusion criteria were signs and symptoms of complicated S aureus bloodstream infection, non-removable foreign devices, and severe comorbidity. The composite primary endpoint was the occurrence of any complication related to S aureus bloodstream infection (relapsing S aureus bloodstream infection, deep-seated infection, and mortality attributable to infection) within 90 days, assessed in the intention-to-treat population by clinical assessors who were masked to treatment assignment. Adverse events were assessed in all participants who received at least one dose of study medication (safety population). Due to slow recruitment, the scientific advisory committee decided on Jan 15, 2018, to stop the trial after 215 participants were randomly assigned (planned sample size was 430 participants) and to convert the planned interim analysis into the final analysis. The decision was taken without knowledge of outcome data, at a time when 126 participants were enrolled. The new sample size accommodated a non-inferiority margin of 10%; to claim non-inferiority, the upper bound of the 95% CI for the treatment difference (stratified by centre) had to be below 10 percentage points. The trial is closed to recruitment and is registered with ClinicalTrials.gov (NCT01792804), the German Clinical trials register (DRKS00004741), and EudraCT (2013-000577-77). FINDINGS: Of 5063 patients with S aureus bloodstream infection assessed for eligibility, 213 were randomly assigned to switch to oral therapy (n=108) or to continue intravenous therapy (n=105). Mean age was 63·5 (SD 17·2) years and 148 (69%) participants were male and 65 (31%) were female. In the oral switch group, 14 (13%) participants met the primary endpoint versus 13 (12%) in the intravenous group, with a treatment difference of 0·7 percentage points (95% CI -7·8 to 9·1; p=0·013). In the oral switch group, 36 (34%) of 107 participants in the safety population had at least one serious adverse event compared with 27 (26%) of 103 participants in the intravenous group (p=0·29). INTERPRETATION: Oral switch antimicrobial therapy was non-inferior to intravenous standard therapy in participants with low-risk S aureus bloodstream infection. However, it is necessary to carefully assess patients for signs and symptoms of complicated S aureus bloodstream infection at the time of presentation and thereafter before considering early oral switch therapy. FUNDING: Deutsche Forschungsgemeinschaft. TRANSLATIONS: For the German, Spanish, French and Dutch translations of the abstract see Supplementary Materials section.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 16/01/2024
• Auteurs : Diane Galbois-LehallePhilippe Stoffel-Munck
• Organismes : Institut Catholique de Paris (ICP) Université Paris 1 Panthéon-Sorbonne Institut de Recherche juridique de la Sorbonne André Tunc

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Résumé : Après la réforme du droit commun des contrats, l’œuvre de modernisation du Code civil en matière contractuelle se poursuit pas à pas. C’est désormais au tour du droit des contrats spéciaux, tant pour réduire le décalage entre le Code de 1804 et le droit positif, que pour le mettre en cohérence avec le droit commun réformé. Nommé par la Chancellerie pour présider une commission de réforme du droit des contrats spéciaux, le Professeur Philippe Stoffel-Munck s’est entouré à cette fin d’universitaires et de praticiens renommés. Leurs travaux embrassent les contrats de vente, d’échange, de location, de prêt à usage, de prêt de consommation, de dépôt, d’entreprise, de mandat et les contrats aléatoires, qui composent cette « fresque des contrats spéciaux » qui est « comme une voie lactée » (G. Cornu). Un important colloque rassemblant, en présence de la Chancellerie, les membres de cette commission a été organisé par son président et par Madame Galbois-Lehalle, directrice du département de Droit de la faculté des sciences sociales de l’Institut catholique de Paris. Il s’est tenu le 23 septembre 2022, à l’Institut catholique, en vue de discuter les propositions de l’avant-projet. Original dans son format, ce colloque a permis aux membres de la commission de réforme de se prêter à l’exercice de la contradiction avec d’éminents spécialistes des différents contrats spéciaux. Le présent ouvrage rend compte des présentations des uns, des critiques des autres, ainsi que des riches discussions auxquelles leur confrontation a donné lieu. Depuis lors, le groupe de travail présidé par le Professeur Philippe Stoffel-Munck a remis son rapport au garde des Sceaux, et la Chancellerie travaille désormais à l’élaboration du projet de réforme. Les réflexions contenues dans le présent ouvrage offriront assurément de précieux outils d’analyse – et éclaireront la genèse – de ce futur texte. Avec les contributions de Alain Bénabent, Jean-Daniel Bretzner, Garance Cattalano, Philippe Delebecque, Bertrand Fages, Diane Galbois-Lehalle, Pierre-Yves Gautier, Alain Ghozi, Dimitri Houtcieff, Gwendoline Lardeux, Laurent Leveneur, Blandine Mallet-Bricout, Yves Maunand, Pascal Puig, Jacques Raynard, Catherine Raynouard, Alain Sériaux, Jean-Baptiste Seube, Philippe Stoffel-Munck, Antoine Touzain. Inclus le rapport rédigé et commenté par la commission de réforme et remis au garde des Sceaux.

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• Type de publi. : Article dans une revue
• Date de publi. : 11/01/2024
• Auteurs : Harry EtiennePierre-Benoît PagèsJules IquillePierre Emmanuel FalcozLaurent BrouchetJean-Philippe BerthetFrançoise Le Pimpec BarthesJacques JougonMarc FilaireJean-Marc BasteValentine AnneStéphane RenaudThomas d'AnnovilleJean Pierre MeunierChristophe JayleChristian DromerAgathe Seguin-GiveletAntoine LegrasPhilippe RinieriSophie Jaillard-TheryVincent MargotPascal-Alexandre ThomasMarcel DahanPierre Mordant
• Organismes : Neurophysiologie Respiratoire Expérimentale et Clinique CHU Tenon [AP-HP] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Hôpital du Bocage CHU Amiens-Picardie Nouvel Hôpital Civil de Strasbourg Université de Strasbourg Centre Hospitalier Universitaire de Toulouse Service de chirurgie thoracique et cardio-vasculaire Hôpital Européen Georges Pompidou [APHP] Université Paris Cité Hôpital Haut-Lévêque [CHU Bordeaux] Unité de Nutrition Humaine Département Chirurgie Thoracique et Endocrinienne [Centre Jean Perrin - Clermont-Ferrand] CHU Rouen Hôpitaux Privés de Metz - Hôpital Robert Schuman -UNEOS Département d'hématologie et oncologie pédiatrique [CHU La Réunion] Service de chirurgie thoracique et cardio-vasculaire Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Institut Mutualiste de Montsouris Centre Hospitalier Régional Universitaire de Tours UNIROUEN - UFR Santé Advestis
• Publié dans ERJ Open Research le 30/08/2017

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Résumé : Introduction Non-small cell lung cancer (NSCLC) is often associated with compromised lung function. Real-world data on the impact of surgical approach in NSCLC patients with compromised lung function are still lacking. The objective of this study is to assess the potential impact of minimally invasive surgery (MIS) on 90-day post-operative mortality after anatomic lung resection in high-risk operable NSCLC patients. Methods We conducted a retrospective multicentre study including all patients who underwent anatomic lung resection between January 2010 and October 2021 and registered in the Epithor database. High-risk patients were defined as those with a forced expiratory volume in 1 s (FEV 1 ) or diffusing capacity of the lung for carbon monoxide ( D LCO ) value below 50%. Co-primary end-points were the impact of risk status on 90-day mortality and the impact of MIS on 90-day mortality in high-risk patients. Results Of the 46 909 patients who met the inclusion criteria, 42 214 patients (90%) with both preoperative FEV 1 and D LCO above 50% were included in the low-risk group, and 4695 patients (10%) with preoperative FEV 1 and/or preoperative D LCO below 50% were included in the high-risk group. The 90-day mortality rate was significantly higher in the high-risk group compared to the low-risk group (280 (5.96%) versus 1301 (3.18%); p<0.0001). In high-risk patients, MIS was associated with lower 90-day mortality compared to open surgery in univariate analysis (OR=0.04 (0.02–0.05), p<0.001) and in multivariable analysis after propensity score matching (OR=0.46 (0.30–0.69), p<0.001). High-risk patients operated through MIS had a similar 90-day mortality rate compared to low-risk patients in general (3.10% versus 3.18% respectively). Conclusion By examining the impact of surgical approaches on 90-day mortality using a nationwide database, we found that either preoperative FEV 1 or D LCO below 50% is associated with higher 90-day mortality, which can be reduced by using minimally invasive surgical approaches. High-risk patients operated through MIS have a similar 90-day mortality rate as low-risk patients.

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Fichiers liés : ERJ Open Res-2024-Etienne-00653-2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 10/01/2024
• Auteurs : Céline RowNicolas LechevalierJean-Philippe VialAguirre MimounJean Noel BastieIngrid LafonArnaud PigneuxThibaut LeguayMary CallananMarc MaynadieMarie C BénéPierre Yves DumasJulien Guy
• Organismes : Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Center for Translational and Molecular medicine [Dijon - UMR1231] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Center for Translational and Molecular medicine [Dijon - UMR1231] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Center for Translational and Molecular medicine [Dijon - UMR1231] Center for Translational and Molecular medicine [Dijon - UMR1231] Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Center for Translational and Molecular medicine [Dijon - UMR1231]
• Publié dans eJHaem le 08/06/2021

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Résumé : Risk stratification and treatment response evaluation are key features in acute myeloid leukemia (AML) management. Immunophenotypic and molecular approaches all rely on the detection of persisting leukemic cells by measurable residual disease techniques. A new approach is proposed here by assessing medullary myeloid maturation by flow cytometry through a myeloid progenitor ratio (MPR). The normal MPR range was defined using reference normal bone marrows (n = 48). MPR was considered balanced if between 1 and 4 and unbalanced if < 1 or > 4. MPR was retrospectively assessed at baseline and post-induction for 206 newly diagnosed AML patients eligible for intensive treatment from two different French centers. All AML baseline MPR were unbalanced and thus significantly different from normal MPR (p < 0.0001). Patients with an unbalanced MPR after induction had worse 3-year overall survival (OS) (44.4% vs. 80.2%, HR, 2.96; 95% CI, 1.81-4.84, p < 0.0001) and 3-year relapse free survival (RFS) (38.7% vs. 64.4%, HR, 2.11; 95% CI, 1.39-3.18, p < 0.001). In multivariate analysis, postinduction unbalanced MPR was significantly associated with shorter OS and RFS regardless of the European LeukemiaNet 2010 risk stratification or NPM1/FLT3-ITD status. A balanced postinduction MPR conversely conferred favorable outcomes and reflects medullary myeloid recovery.

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Fichiers liés : JHA2-5-84.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 10/01/2024
• Auteurs : Declan L M CooperSimon L. LewisMartin SullivanPaulo I PradoHans ter SteegeNicolas BarbierFerry SlikBonaventure SonkéCorneille E N EwangoStephen Adu-BreduKofi Affum-BaffoeDaniel P P de AguiarManuel Augusto Ahuite ReateguiShin-Ichiro AibaBianca Weiss AlbuquerqueFrancisca Dionízia de Almeida MatosAlfonso AlonsoChristian A AmaniDário Dantas Do AmaralIêda Leão Do AmaralAna AndradeIres Paula de Andrade MirandaIlondea B AngoboyAlejandro Araujo-MurakamiNicolás Castaño ArboledaLuzmila ArroyoPeter AshtonGerardo A Aymard CCláudia BaiderTimothy R BakerMichael Philippe Bessike BalingaHenrik BalslevLindsay F BaninOlaf S BánkiChristopher BaralotoEdelcilio Marques BarbosaFlávia Rodrigues BarbosaJos BarlowJean-Francois BastinHans BeeckmanSerge BegneNatacha Nssi BengoneErika BerenguerNicholas BerryRobert BitarihoPascal BoeckxJan BogaertBernard BonyomaPatrick BoundjaNils BourlandFaustin Boyemba BoselaFabian BrambachRoel BrienenDavid F R P BurslemJosé Luís CamargoWegliane CampeloAngela CanoSasha CárdenasDairon Cárdenas LópezRainiellen de Sá CarpanedoYrma Andreina Carrero MárquezFernanda Antunes CarvalhoLuisa Fernanda CasasHernán CastellanosCarolina V CastilhoCarlos CerónColin A ChapmanJerome ChavePhourin ChhangWanlop ChutipongGeorge B ChuyongBruno Barçante Ladvocat CintraConnie J ClarkFernanda Coelho de SouzaJames A ComiskeyDavid A CoomesFernando Cornejo ValverdeDiego F CorreaFlávia R C CostaJanaina Barbosa Pedrosa CostaPierre CouteronHeike CulmseeAida Cuni-SanchezFrancisco DallmeierGabriel DamascoGilles DaubyNállarett DávilaHilda Paulette Dávila DozaJose Don T de AlbanRafael L de AssisCharles de CanniereThales de HaullevilleMarcelo de Jesus Veiga CarimLayon O DemarchiKyle G DexterAnthony Di FioreHazimah Haji Mohammad DinMathias I DisneyBrice Yannick DjiofackMarie-Noël K DjuikouoTran Van DoJean-Louis DoucetFreddie C DraperVincent DroissartJoost F DuivenvoordenJulien EngelVittoria EstienneWilliam Farfan-RiosSophie FausetKenneth J FeeleyYuri Oliveira FeitosaTed R FeldpauschCid FerreiraJoice FerreiraLeandro Valle FerreiraChristine D FletcherBernardo Monteiro FloresAlusine FofanahErnest G FoliÉmile FontyGabriella M FredrikssonAlfredo FuentesDavid GalbraithGeorge Pepe Gallardo GonzalesKarina Garcia-CabreraRoosevelt García-VillacortaVitor H F GomesRicardo Zárate GómezTherany GonzalesRogerio GribelMarcelino Carneiro GuedesJuan Ernesto GuevaraKhalid Rehman HakeemJefferson S HallKeith C HamerAlan C HamiltonDavid J HarrisRhett D HarrisonTerese B HartAndy HectorTerry W HenkelJohn HerbohnMireille B N HockembaBruce HoffmanMilena HolmgrenEuridice N Honorio CoronadoIsau Huamantupa-ChuquimacoWannes HubauNobuo ImaiMariana Victória IrumePatrick A JansenKathryn J JefferyEliana M JimenezTommaso JuckerAndré Braga JunqueiraMichelle KalamandeenNarcisse G KamdemKuswata KartawinataEmmanuel Kasongo YakusuJohn M KatemboElizabeth KearsleyDavid KenfackMichael KesslerThiri Toe KhaingTimothy J KilleenKanehiro KitayamaBente KlitgaardNicolas LabrièreYves LaumonierSusan G W LauranceWilliam F LauranceFélix LaurentTinh Cong LeTrai Trong LeMiguel E LealEvlyn Márcia Leão de Moraes NovoAurora LevesleyMoses B LibalahJuan Carlos LiconaDiógenes de Andrade Lima FilhoJeremy A LindsellAline LopesMaria Aparecida LopesJon C LovettRichard LoweJosé Rafael LozadaXinghui LuNestor K LuambuaBruno Garcia LuizePaul MaasJosé Leonardo Lima MagalhãesWilliam E MagnussonNi Putu Diana MahayaniJean-Remy MakanaYadvinder MalhiLorena Maniguaje RincónAsyraf MansorAngelo Gilberto ManzattoBeatriz S MarimonBen Hur Marimon-JuniorAndrew R MarshallMaria Pires MartinsFaustin M MbayuMarcelo Brilhante de MedeirosItalo MesonesFaizah MetaliVianet MihindouJérôme MilletWilliam MillikenHugo F MogollónJean-François MolinoMohd Nizam Mohd. SaidAbel Monteagudo MendozaJuan Carlos MonteroSam MooreBonifacio MostacedoLinder Felipe Mozombite PintoSharif Ahmed MukulPantaleo K T MunishiHidetoshi NagamasuHenrique Eduardo Mendonça NascimentoMarcelo Trindade NascimentoDavid NeillReuben NilusJanaína Costa NoronhaLaurent NsengaPercy Núñez VargasLucas OjoAlexandre A OliveiraEdmar Almeida de OliveiraFidèle Evouna OndoWalter Palacios CuencaSusamar PansiniMarcelo Petratti PansonatoMarcos Ríos ParedesEkananda PaudelDaniela PaulettoRichard G PearsonJosé Luis Marcelo PenaR. Toby PenningtonCarlos A PeresAndrea PermanaPascal PetronelliMaria Cristina Peñuela MoraJuan Fernando PhillipsOliver L PhillipsGeorgia PickavanceMaria Teresa Fernandez PiedadeNigel C A PitmanPierre PlotonAndreas PopelierJohn R PoulsenAdriana PrietoRichard B PrimackHari PriyadiLan QieAdriano Costa QuaresmaHelder Lima de QueirozHirma Ramirez-AnguloJosé Ferreira RamosNeidiane Farias Costa ReisJan ReitsmaJuan David Cardenas RevillaTerhi RiuttaGonzalo Rivas-TorresIyan RobiansyahMaira RochaDomingos de Jesus RodriguesM. Elizabeth Rodriguez-RonderosFrancesco RoveroAndes H RozakAgustín RudasErvan RutishauserDaniel SabatierLe Bienfaiteur SagangAdeilza Felipe SampaioIsmayadi SamsoedinManichanh SatdichanhJuliana SchiettiJochen SchöngartVeridiana Vizoni ScudellerNaret SeuaturienDouglas SheilRodrigo SierraMiles R SilmanThiago Sanna Freire SilvaJosé Renan da Silva GuimarãesMurielle Simo-DroissartMarcelo Fragomeni SimonPlinio SistThaiane R SousaEmanuelle de Sousa FariasLuiz de Souza CoelhoDominick V SpracklenSuzanne M StasRobert SteinmetzPablo R StevensonJuliana StroppRahayu S SukriTerry C H SunderlandEizi SuzukiMichael D SwaineJianwei TangJames TaplinDavid M TaylorJ. Sebastián TelloJohn TerborghNicolas TexierIda TheiladeDuncan W ThomasRaquel ThomasSean C ThomasMilton TiradoBenjamin ToirambeJosé Julio de ToledoKyle W TomlinsonArmando Torres-LezamaHieu Dang TranJohn Tshibamba MukendiRoven D TumanengMaria Natalia UmañaPeter M UmunayLigia Estela Urrego GiraldoElvis H Valderrama SandovalLuis Valenzuela GamarraTinde R van AndelMartin van de BultJaqueline van de PolGeertje van der HeijdenRodolfo VasquezCésar I A VelaEduardo Martins VenticinqueHans VerbeeckRizza Karen A VeridianoAlberto VicentiniIma Célia Guimarães VieiraEmilio Vilanova TorreDaniel VillarroelBoris Eduardo Villa ZegarraJason VleminckxPatricio von HildebrandVincent Antoine VosCorine VriesendorpEdward L WebbLee J T WhiteSerge WichFlorian WittmannRoderick ZagtRunguo ZangCharles Eugene ZartmanLise ZemaghoEgleé L ZentStanford Zent
• Organismes : University College London [UCL] University College London [UCL] University of Leeds Universidade de São Paulo = University of São Paulo Naturalis Biodiversity Center [Leiden] Botanique et Modélisation de l'Architecture des Plantes et des Végétations Universiti Brunei Darussalam University of Yaoundé 1 = Université de Yaoundé I International Joint Laboratory DYCOFAC Université de Kisangani Forestry Research Institute of Ghana Instituto Nacional de Pesquisas da Amazônia = National Institute of Amazonian Research Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations
• Publié dans Nature le 29/10/2020

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Résumé : Trees structure the Earth’s most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations 1–6 in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia. We estimate that 2.2%, 2.2% and 2.3% of species comprise 50% of the tropical trees in these regions, respectively. Extrapolating across all closed-canopy tropical forests, we estimate that just 1,053 species comprise half of Earth’s 800 billion tropical trees with trunk diameters of at least 10 cm. Despite differing biogeographic, climatic and anthropogenic histories 7 , we find notably consistent patterns of common species and species abundance distributions across the continents. This suggests that fundamental mechanisms of tree community assembly may apply to all tropical forests. Resampling analyses show that the most common species are likely to belong to a manageable list of known species, enabling targeted efforts to understand their ecology. Although they do not detract from the importance of rare species, our results open new opportunities to understand the world’s most diverse forests, including modelling their response to environmental change, by focusing on the common species that constitute the majority of their trees.

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Fichiers liés : Cooper_etal_Nature_2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 09/01/2024
• Auteurs : Adam Yassin JaziriWilliam PlurielAndrea BocchieriPanek EmilieLucas TeinturierAnastasia IvanovaNatalia E RektsiniPierre DrossartJean-Philippe BeaulieuAurélien FalcoJérémy LeconteLorenzo V MugnaiOlivia Venot
• Organismes : PLANETO - LATMOS Observatoire Astronomique de l'Université de Genève Laboratoire d'Astrophysique de Bordeaux [Pessac] Observatoire Astronomique de l'Université de Genève Dipartimento di Fisica [Roma La Sapienza] Institut d'Astrophysique de Paris Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Laboratoire de Météorologie Dynamique (UMR 8539) PLANETO - LATMOS Institut d'Astrophysique de Paris School of Natural Sciences [Hobart] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Institut d'Astrophysique de Paris Institut d'Astrophysique de Paris School of Natural Sciences [Hobart] Institut de Physique du Globe de Paris Astrophysique Interprétation Modélisation Laboratoire d'Astrophysique de Bordeaux [Pessac] School of Physics and Astronomy [Cardiff] Dipartimento di Fisica [Roma La Sapienza] Department of Physics and Astronomy [UCL London] INAF - Osservatorio Astronomico di Palermo Laboratoire Interuniversitaire des Systèmes Atmosphériques Laboratoire Interuniversitaire des Systèmes Atmosphériques
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Observed exoplanet transit spectra are usually retrieved using 1D models to determine atmospheric composition. However, planetary atmospheres are 3D. With the new state-of-the-art James Webb Space Telescope (JWST) and future space telescopes such as Ariel (Atmospheric Remote-sensing Infrared Exoplanet Large-survey), we will be able to obtain increasingly accurate transit spectra. The 3D effects on the spectra will be visible, and we can expect biases in the 1D extractions. In order to elucidate these biases, we have built theoretical observations of transit spectra, from 3D atmospheric modeling through transit modeling to instrument modeling. For this purpose, we used a global climate model (GCM) to simulate the atmosphere, a 3D radiative transfer model to calculate theoretical transmission spectra, and adapted instrument software from JWST and Ariel to reproduce telescope noise. Next, we used a 1D radiative transfer inversion model to retrieve the known input atmosphere and disentangle any biases that might be observed. The study was done from warm planets to ultra-hot planets to assess biases as a function of average planet temperature. Three-dimensional effects are observed to be strongly nonlinear from the coldest to the hottest planets. These effects also depend on the planet’s metallicity and gravity. Considering equilibrium chemistry, 3D effects are observed through very strong variations in certain features of the molecule or very small variations over the whole spectrum. We conclude that we cannot rely on the uncertainty of retrievals at all pressures, and that we must be cautious about the results of retrievals at the top of the atmosphere. However the results are still fairly close to the truth at mid-altitudes (those probed). We also need to be careful with the chemical models used for planetary atmosphere. If the chemistry of one molecule is not correctly described, this will bias all the others, and the retrieved temperature as well. Finally, although tting a wider wavelength range and higher resolution has been shown to increase retrieval accuracy, we show that this could depend on the wavelength range chosen, due to the accuracy on modeling the different features. In any case, 1D retrievals are still correct for the detection of molecules, even in the event of an erroneous abundance retrieval.

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Fichiers liés : aa47379-23.pdf

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