Philippe Jean-Pierre
Professeur des universités en sciences de gestion
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Search for the nonresonant and resonant production of a Higgs boson in association with an additional scalar boson in the $γγττ$ final state in proton-proton collisions at $\sqrt{s}$ = 13 TeV
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 09/07/2025
- Auteurs : Aram HayrapetyanArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerSuman ChatterjeeKonstantinos DamanakisMarko DragicevicPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenThomas van LaerPierre van MechelenNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenSteven LowetteInna MakarenkoDenise MüllerStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosJohny JaramilloAli KhalilzadehFakhri Alam KhanKyeongpil LeeAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerMaarten de CoenDidar DoburGul GokbulutYanwen HongJoscha KnolleLuka LambrechtDavid MarckxKevin Mota AmariloKirill SkovpenNiels van den BosscheJan van der LindenLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoClaudio CaputoJerome de Favereau de JeneretChristophe DelaereIzzeddin Suat DonertasAndrea GiammancoAhmet Oguz GuzelSandhya JainVincent LemaitreJindrich LidrychPaola MastrapasquaTu Thong TranSemra TurkcaparGilvan AlvesEduardo CoelhoGilson Correia SilvaCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorMapse Barroso Ferreira FilhoHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaTulio Laux KuhnMatheus MacedoJordan MartinsLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielCesar Augusto BernardesLuigi CalligarisThiago TomeiEduardo de Moraes GregoresIsabela Maietto SilverioPedro G MercadanteSergio F 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WangDaniel AllyAndrés G DelannoySara FiorendiSamuel HigginbothamTova HolmesAnkush Reddy KanugantiNimmitha KarunarathnaLawrence LeeEmery NibigiraStefan SpanierDevin AebiMuhammad AhmadTowsifa AkhterKonstantin AndrosovOthmane BouhaliRicardo EusebiJason GilmoreTao HuangTeruki KamonHyunyong KimSifu LuoRyan MuellerDavid OvertonDenis RathjensAlexei SafonovNural AkchurinJordan DamgovNiramay GogateAdil HussainYelbir KazhykarimKamal LamichhaneSung Won LeeAaron MankelTimo PeltolaIgor VolobouevEric AppeltYi ChenSenta GreeneAlfredo GurrolaWillard JohnsRaghav Kunnawalkam ElayavalliAndrew MeloFrancesco RomeoPaul SheldonShengquan TuoJulia VelkovskaJussi ViinikainenBryan CardwellHeewon ChungBradley CoxJohn HakalaRobert HiroskyAlexander LedovskoyCristina MantillaChristopher NeuSaptaparna BhattacharyaPaul Edmund KarchinAnagha AravindSunanda BanerjeeKevin BlackTulika BoseElise ChavezSridhara DasuPieter EveraertsCamilla GalloniHe HeMatthew HerndonAlain HerveCharis Kleio KorakaArmando LanaroRichard LovelessJithin Madhusudanan SreekalaAbhishikth MallampalliAbdollah MohammadiSusmita MondalGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinDzmitry BudkouskiIgor GolutvinIlya GorbunovVladimir KarjavineVladimir KorenkovAlexander LanevAlexander MalakhovViktor MatveevVladimir PalichikVictor PerelyginMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaVitaly SmirnovOleg TeryaevNikolay VoytishinBekhzod S YuldashevAnatoli ZarubinIlia ZhizhinGenady GavrilovVictor GolovtcovYury IvanovVictor KimPetr LevchenkoVictor MurzinVadim OreshkinDmitry SosnovValentin SulimovLev UvarovAlexey VorobyevYuri AndreevAlexander DermenevSergei GninenkoNikolai GolubevAnton KarneyeuDmitrii KirpichnikovMikhail KirsanovNikolai KrasnikovIrina TlisovaAlexander ToropinTagir AushevKirill IvanovVladimir GavrilovNatalia LychkovskayaAlexander NikitenkoVladimir PopovAlexander ZhokinRuslan ChistovMikhail DanilovSergey PolikarpovVladimir AndreevMaksim AzarkinMartin KirakosyanAdel TerkulovEdouard BoosViacheslav BunichevMikhail DubininLev DudkoAlexander ErshovVyacheslav KlyukhinOlga KodolovaStepan ObraztsovMaxim PerfilovSergey PetrushankoViktor SavrinGeorge VorotnikovVladimir BlinovTatyana DimovaAleksei KozyrevOlesia RadchenkoYuri SkovpenVassili KachanovSergei SlabospitskiiAndrey UzunianAnton BabaevVladislav BorshchDmitry Druzhkin
Search for the nonresonant and resonant production of a Higgs boson in association with an additional scalar boson in the $γγττ$ final state in proton-proton collisions at $\sqrt{s}$ = 13 TeV
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 09/07/2025
- Auteurs : Aram HayrapetyanArmen TumasyanWolfgang AdamJanik Walter AndrejkovicLisa BenatoThomas BergauerSuman ChatterjeeKonstantinos DamanakisMarko DragicevicPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoIvan MikulecJochen SchieckRobert SchöfbeckDennis SchwarzMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenThomas van LaerPierre van MechelenNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenSteven LowetteInna MakarenkoDenise MüllerStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosJohny JaramilloAli KhalilzadehFakhri Alam KhanKyeongpil LeeAndrea MalaraMuhammad Aamir ShahzadLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerMaarten de CoenDidar DoburGul GokbulutYanwen HongJoscha KnolleLuka LambrechtDavid MarckxKevin Mota AmariloKirill SkovpenNiels van den BosscheJan van der LindenLiam WezenbeekSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoClaudio CaputoJerome de Favereau de JeneretChristophe DelaereIzzeddin Suat DonertasAndrea GiammancoAhmet Oguz GuzelSandhya JainVincent LemaitreJindrich LidrychPaola MastrapasquaTu Thong TranSemra TurkcaparGilvan AlvesEduardo CoelhoGilson Correia SilvaCarsten HenselThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorMapse Barroso Ferreira FilhoHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaTulio Laux KuhnMatheus MacedoJordan MartinsLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielCesar Augusto BernardesLuigi CalligarisThiago TomeiEduardo de Moraes GregoresIsabela Maietto SilverioPedro G MercadanteSergio F NovaesBreno OrzariSandra PadulaAleksandar AleksandrovGeorgy AntchevRoumyana HadjiiskaPlamen IaydjievMilena MishevaMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovElton ShumkaSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurTongguang ChengTahir JavaidLi YuanZhen HuZhengchen LiangJinfeng LiuGuo-Ming ChenHe-Sheng ChenMingshui ChenFabio IemmiChun-Hua JiangAnshul KapoorHongbo LiaoZhenan LiuRamkrishna SharmaJia-Ning SongJunquan TaoChu WangJin WangZebing WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinXiaohu SunDayong WangHeng YangLicheng ZhangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerBolin LiKai YiJingqing ZhangYuji LiZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJose Antonio Reyes VegaCésar RendónManuel RodriguezAnderson Alexis Ruales BarbosaJosé David Ruiz AlvarezDuje GiljanovicNikola GodinovicDamir LelasAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicBhakti Kanulal ChitrodaDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisKonstantinos ChristoforouAndreas HadjiagapiouChristos LeonidouJehad MousaCharalambos NicolaouLeonidas PaizanosFotios PtochosPanos A RazisHans RykaczewskiHalil SakaAnton StepennovMiroslav FingerMichael FingerAntonin KvetonEdy AyalaEdgar Carrera JarrinHassan AbdallaYasser AssranBasma El-MahdyMuhammad Abdullah Abdulfattah MuhammadMohammed MahmoudKarl EhatahtMario KadastikTorben LangeChristine NielsenJoosep PataMartti RaidalLaurits TaniChristian VeelkenHenning KirschenmannKenneth OsterbergMikko VoutilainenShudhashil BharthuarNurfikri Bin NorjoharuddeenErik BrückenFrancisco Ignacio Garcia FuentesPatin InkaewKimmo Tuomas Samuli KallonenTapio LampénKati Lassila-PeriniSami LehtiTomas LindénMikael MyllymäkiMilla-Maarit RantanenHannu SiikonenJorma TuominiemiPanja-Riina LuukkaHenri PetrowMarc BesanconFabrice CoudercMarc DejardinDaniel DenegriJean-Louis FaureFederico FerriSerguei GanjourPhilippe GrasGautier Hamel de MonchenaultMintu KumarVictor LohezicJulie MalclesFrancesco OrlandiLouis PortalesAndré RosowskyMehmet Özgür SahinAurore Savoy-NavarroPolina SimkinaMaksym TitovMarta TornagoFlorian BeaudetteGiacomo BoldriniPhilippe BussonAlessandra CappatiClaude CharlotMarco ChiusiTheo Damien CuissetFlorian DamasOlivier DavignonAdinda de WitIsaac Telford EhleBruno Afonso Fontana Santos AlvesShamik GhoshAndrew GilbertRaphael Granier de CassagnacAlexandre HakimiBharadwaj HarikrishnanLida KalipolitiGeliang LiuMatthew NguyenChristophe OchandoRoberto SalernoJean-Baptiste SauvanYves SiroisLourdes Urda GómezElena VernazzaAlexandre ZabiAmina ZghicheJean-Laurent AgramJeremy AndreaDylan ApparuDaniel BlochJean-Marie BromEric Christian ChabertCaroline CollardSaskia FalkeUlrich GoerlachRaphael 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Résumé : The results of a search for the production of two scalar bosons in final states with two photons and two tau leptons are presented. The search considers both nonresonant production of a Higgs boson pair, HH, and resonant production via a new boson X which decays either to HH or to H and a new scalar Y. The analysis uses up to 138 fb$^{-1}$ of proton-proton collision data, recorded between 2016 and 2018 by the CMS experiment at the LHC at a center-of-mass energy of 13 TeV. No evidence for signal is found in the data. For the nonresonant production, the observed (expected) upper limit at 95% confidence level (CL) on the HH production cross section is set at 930 (740) fb, corresponding to 33 (26) times the standard model prediction. At 95% CL, HH production is observed (expected) to be excluded for values of $κ_λ$ outside the range between $-$12 ($-$9.4) and 17 (15). Observed (expected) upper limits at 95% CL for the XHH cross section are found to be within 160 to 2200 (200 to 1800) fb, depending on the mass of X. In the X $\to$ Y($γγ$)H($ττ$) search, the observed (expected) upper limits on the product of the production cross section and decay branching fractions vary between 0.059$-$1.2 fb (0.087$-$0.68 fb). For the X $\to$ Y($γγ$)H($ττ$) search the observed (expected) upper limits on the product of the production cross section and Y $to$ $γγ$ branching fraction vary between 0.69$-$15 fb (0.73$-$8.3 fb) in the low Y mass search, tightening constraints on the next-to-minimal supersymmetric standard model, and between 0.64$-$10 fb (0.70$-$7.6 fb) in the high Y mass search.
Source -
Search for single production of vector-like quarks decaying into $W(\ell ν)b$ in $pp$ collisions at $\sqrt{s} = 13$ TeV with the ATLAS detector
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 09/07/2025
- Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczYiming AbulaitiBobby Samir AcharyaAnke AckermannClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatthew John AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiFaig AhmadovSudha AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatBrahim AitbenchikhMelike AkbiyikTorsten AkessonAndrei AkimovDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertPietro AlbicoccoGuillaume AlbouySara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeJonny AllenJulia Frances AllenPhilip Patrick AllportAlberto AloisioFrancisco AlonsoCristiano AlpigianiZainab Mohammad K AlsolamiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlChristoph AmesThiziri AmezzaDante AmideiBaktash AminiKyle AmirieArtem AmirkhanovSusana Patricia Amor dos SantosKieran Robert AmosDimitra AmperiadouShiwen AnChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaKanae AsaiShoji AsaiSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham 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Search for single production of vector-like quarks decaying into $W(\ell ν)b$ in $pp$ collisions at $\sqrt{s} = 13$ TeV with the ATLAS detector
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 09/07/2025
- Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczYiming AbulaitiBobby Samir AcharyaAnke AckermannClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatthew John AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiFaig AhmadovSudha AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatBrahim AitbenchikhMelike AkbiyikTorsten AkessonAndrei AkimovDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertPietro AlbicoccoGuillaume AlbouySara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiWael AlkakhiCorentin AllaireBenedict AllbrookeJonny AllenJulia Frances AllenPhilip Patrick AllportAlberto AloisioFrancisco AlonsoCristiano AlpigianiZainab Mohammad K AlsolamiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiMohamed AlyYara Do Amaral CoutinhoAlessandro AmblerChristoph AmelungMaximilian AmerlChristoph AmesThiziri AmezzaDante AmideiBaktash AminiKyle AmirieArtem AmirkhanovSusana Patricia Amor dos SantosKieran Robert AmosDimitra AmperiadouShiwen AnChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaKanae AsaiShoji AsaiSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham 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- Organismes : Centre de Physique des Particules de Marseille Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie AstroParticule et Cosmologie Laboratoire des deux Infinis de Toulouse AstroParticule et Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Laboratoire de Physique des 2 Infinis Irène Joliot-Curie
Résumé : A search for single production of a vector-like quark $Q$, which could be either a singlet $T$, with charge $\tfrac23$, or a $Y$ from a $(T,B,Y)$ triplet, with charge $-\tfrac43$, is performed using data from proton-proton collisions at a centre-of-mass energy of 13 TeV. The data correspond to the full integrated luminosity of 140 fb$^{-1}$ recorded with the ATLAS detector during Run 2 of the Large Hadron Collider. The analysis targets $Q \to Wb$ decays where the $W$ boson decays leptonically. The data are found to be consistent with the expected Standard Model background, so upper limits are set on the cross-section times branching ratio, and on the coupling of the $Q$ to the Standard Model sector for these two benchmark models. Effects of interference with the Standard Model background are taken into account. For the singlet $T$, the 95% confidence level limit on the coupling strength $κ$ ranges between 0.22 and 0.52 for masses from 1150 to 2300 GeV. For the $(T,B,Y)$ triplet, the limits on $κ$ vary from 0.14 to 0.46 for masses from 1150 to 2600 GeV.
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Meningeal Embolization for Preventing Chronic Subdural Hematoma Recurrence After Surgery
- Type de publi. : Article dans une revue
- Date de publi. : 08/07/2025
- Auteurs : Eimad ShotarBertrand MathonHenri SalleAymeric RouchaudCharbel MounayerNicolas BricoutJean-Paul LejeuneKevin JanotAymeric AmelotOlivier NaggaraAlexandre RouxStéphane GoutagnyAlexis GuédonEmmanuel HoudartHervé BrunelJean-François HakLucas TroudeHenry DufourAnne-Laure BernatTitien TuilierDamien BressonCaroline ApraMathilde FouetSimon EscalardDorian ChauvetKevin PrematSaid LebbahAgnès DechartresFrédéric ClarenconStéphanie LenckNader-Antoine SourourMahmoud ElhoranyPierre-Marie ChiaroniJulien AllardEric BarberisMathilde AubertinAdnan AltayebRobert BurnsSacha BensousanHaroun GhannouchiDamien ParatTom BoekenGonzague GuillaumetAlexandru DimanceaHugo TrebernAdrien BethBaptiste BonnetRomain CoudertYohan DucosGiulio Quarta ColossoEmily RiusXavier GuerraSamer SolimanClément PechinéLuca ScarciaVincent DegosAlice JacquensMehdi DrirJugurtha MathoutAnne Sophie MonteroEtienne LefevreMaximilien RichePauline MarijonMichel KalamaridesAlexandre CarpentierAnne-Laure BochAurélien NouetVincent ReinaBertrand BaussartHenri MalaizeWagih Ben HassenDenis TrystramHugo GortaisFinoana Laza NomenjanaharyChristine RodriguezJohan PalludEdouard DezamisEduardo ParragaHoussem FathallahAlessandro MoiraghiChiara BenevelloJean-Pierre Saint MauriceVittorio CivelliMarc-Antoine LabeyrieFrancesco ArpaiaMatteo FantoniRosaria AbbrittiGueorgui IakovlevMathieu FaillotHelene StaquetAdrien Ortiz CarleAlberic BoccoErwah KalsoumFiras FarhatRodrigue JayrRaphael BlancMichel PiotinWilliam BoisseauFrançois DelvoyeQuentin HolayJean-Philippe DesillesHocine RedjemStanislas SmajdaAmira Al-RaaisiSamiya Abi JaoudeJean Marc DelmasFrançois-Léopold MaisonSuzana SalemeGéraud ForestierClément GantoisLeslie LemnosEdouard GueyeBasile KerlerouxAnthony ReyreSébastien BoissonneauThomas GraillonFarah KaissarMikael MeyerAdamou ToutaGuillaume BaucherValentin AvinensThomas PersonnicAdrien MarchalMartin BretznerLucas GrenierMélodie-Anne KarnoubVictor LegrandHenri-Arthur LeroyBastier GougesAmelie ToubolAntoine DevalckeneerLouis ObledRabih AboukaisIulia Pecui-FlorianuGrégoire BoulouisDenis HerbreteauRichard BibiHéloise IferganFouzi BalaIlyess ZemmouraLouise Marie Terrier
Meningeal Embolization for Preventing Chronic Subdural Hematoma Recurrence After Surgery
- Type de publi. : Article dans une revue
- Date de publi. : 08/07/2025
- Auteurs : Eimad ShotarBertrand MathonHenri SalleAymeric RouchaudCharbel MounayerNicolas BricoutJean-Paul LejeuneKevin JanotAymeric AmelotOlivier NaggaraAlexandre RouxStéphane GoutagnyAlexis GuédonEmmanuel HoudartHervé BrunelJean-François HakLucas TroudeHenry DufourAnne-Laure BernatTitien TuilierDamien BressonCaroline ApraMathilde FouetSimon EscalardDorian ChauvetKevin PrematSaid LebbahAgnès DechartresFrédéric ClarenconStéphanie LenckNader-Antoine SourourMahmoud ElhoranyPierre-Marie ChiaroniJulien AllardEric BarberisMathilde AubertinAdnan AltayebRobert BurnsSacha BensousanHaroun GhannouchiDamien ParatTom BoekenGonzague GuillaumetAlexandru DimanceaHugo TrebernAdrien BethBaptiste BonnetRomain CoudertYohan DucosGiulio Quarta ColossoEmily RiusXavier GuerraSamer SolimanClément PechinéLuca ScarciaVincent DegosAlice JacquensMehdi DrirJugurtha MathoutAnne Sophie MonteroEtienne LefevreMaximilien RichePauline MarijonMichel KalamaridesAlexandre CarpentierAnne-Laure BochAurélien NouetVincent ReinaBertrand BaussartHenri MalaizeWagih Ben HassenDenis TrystramHugo GortaisFinoana Laza NomenjanaharyChristine RodriguezJohan PalludEdouard DezamisEduardo ParragaHoussem FathallahAlessandro MoiraghiChiara BenevelloJean-Pierre Saint MauriceVittorio CivelliMarc-Antoine LabeyrieFrancesco ArpaiaMatteo FantoniRosaria AbbrittiGueorgui IakovlevMathieu FaillotHelene StaquetAdrien Ortiz CarleAlberic BoccoErwah KalsoumFiras FarhatRodrigue JayrRaphael BlancMichel PiotinWilliam BoisseauFrançois DelvoyeQuentin HolayJean-Philippe DesillesHocine RedjemStanislas SmajdaAmira Al-RaaisiSamiya Abi JaoudeJean Marc DelmasFrançois-Léopold MaisonSuzana SalemeGéraud ForestierClément GantoisLeslie LemnosEdouard GueyeBasile KerlerouxAnthony ReyreSébastien BoissonneauThomas GraillonFarah KaissarMikael MeyerAdamou ToutaGuillaume BaucherValentin AvinensThomas PersonnicAdrien MarchalMartin BretznerLucas GrenierMélodie-Anne KarnoubVictor LegrandHenri-Arthur LeroyBastier GougesAmelie ToubolAntoine DevalckeneerLouis ObledRabih AboukaisIulia Pecui-FlorianuGrégoire BoulouisDenis HerbreteauRichard BibiHéloise IferganFouzi BalaIlyess ZemmouraLouise Marie Terrier
- Organismes : Service de neurochirurgie [CHU Clichy] Variabilité de réponse aux Psychotropes Health data-and model-driven approaches for Knowledge Acquisition
- Publié dans JAMA Cardiology le 25/10/2020
Résumé : Importance Middle meningeal artery (MMA) embolization has been proposed as a potential treatment for chronic subdural hematoma (CSDH). Objective To assess the efficacy of MMA embolization in reducing the risk of CSDH recurrence at 6 months compared with standard care in patients who underwent an operation and were at high risk of CSDH recurrence. Design, Setting, and Participants Multicenter, open-label, randomized clinical trial with blinded end point assessment. Patients who underwent an operation for CSDH recurrence or a first CSDH episode at high risk of recurrence were recruited from July 2020 to March 2023 in 12 French neurosurgical or comprehensive neurosurgical and interventional neuroradiology centers. Last follow-up took place on November 2, 2023. Intervention Participants were randomized 1:1 to undergo MMA embolization with microparticles within 7 days of surgery (171 patients, intervention group) or standard medical care alone (171 patients, control group). Main Outcomes and Measures The primary end point was the rate of CSDH recurrence at 6 months assessed by an independent, blinded adjudication committee. There were 5 secondary end points, including rates of repeat surgery for homolateral CSDH recurrence during the 6-month follow-up period and embolization procedure–related complications. Results Among 342 randomized patients (median [IQR] age, 77 [68-83] years; 274 [80.1%] male), 308 (90.1%) completed the trial. The primary end point was observed in 24 of 162 (14.8%) and 33 of 157 (21.0%) patients in the intervention and control groups, respectively (after imputation: odds ratio, 0.64 [95% CI, 0.36-1.14]; adjusted absolute difference, −6% [95% CI, −14% to 2%]; P = .13). The groups did not significantly differ in any of the secondary end points. Repeat surgery was performed in 7 of 162 (4.3%) and 13 of 157 (8.3%) patients in the intervention and control groups ( P = .14), respectively. Minor and major embolization procedure–related complications occurred in 3 of 171 (1.8%) and 1 of 171 (0.6%) patients, respectively. Conclusions and Relevance In this randomized clinical trial, among patients who underwent an operation for CSDH recurrence or a first CSDH episode at high risk of recurrence, MMA embolization did not lead to a significantly lower rate of recurrence at 6 months compared with standard medical care alone. However, the magnitude of the effect estimate is consistent with other recent trials, including some that demonstrated the benefit of MMA embolization with nonadhesive liquid embolic agents, and these findings considered together may inform future studies and potential use of this therapeutic approach for CSDH management. Trial Registration ClinicalTrials.gov Identifier: NCT04372147
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Semiautomatic quantification of 3D Histone H3 phosphorylation signals during cell division in Arabidopsis root meristems
- Type de publi. : Article dans une revue
- Date de publi. : 07/07/2025
- Auteurs : Adrienn KelemenMagalie UyttewaalCsaba MáthéPhilippe AndreyDavid BouchezMartine Pastuglia
Semiautomatic quantification of 3D Histone H3 phosphorylation signals during cell division in Arabidopsis root meristems
- Type de publi. : Article dans une revue
- Date de publi. : 07/07/2025
- Auteurs : Adrienn KelemenMagalie UyttewaalCsaba MáthéPhilippe AndreyDavid BouchezMartine Pastuglia
- Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal University of Debrecen Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
- Publié dans New Phytologist le 01/11/2020
Résumé : Posttranslational modification of histones during the cell cycle is a major process controlling many aspects of cell division. Among the variety of histone modifications, mitotic phosphorylation of histone H3 at serine 10 (H3S10ph) plays a crucial role, particularly in proper chromosome segregation. Here we aimed at precisely quantifying this phosphorylation dynamics during mitosis in plant cells in order to reveal molecular pathways involved in this process. We describe an analysis pipeline based on 3D image analysis that allows to semiautomatically quantify H3S10ph in mitotic Arabidopsis root cells. We also developed a new method for the compensation of signal attenuation in Z, based on measurement of objects of interest themselves. We show that this new attenuation correction method allows significant gains in accuracy and statistical power. Using this pipeline, we were able to reveal small H3S10ph differences between cells treated with hesperadin, an inhibitor of an H3S10ph kinase, or between Arabidopsis mutants affected in PP2A phosphatase activity. This tool opens new avenues to explore such regulatory pathways in plants, using the wealth of genetic materials available in Arabidopsis. It can also be applied to study other histone posttranslational modifications and more generally to any discrete 3D signals.
Fichiers liés : 2025_Kelemen-nph70365.pdf
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Participatory assessment of minor crops: A situated study on hulled wheats
- Type de publi. : Article dans une revue
- Date de publi. : 04/07/2025
- Auteurs : Sofía CorreaMathieu ThomasJustine LepagneulAubin DémontéC.R. B.A.Pierre BerthetJean-Philippe ClairChristian DalmassoCédric MaryDenis MignardHonorine PérinoMarie-Pierre RépécaudStéphane RouvèsLéa BernardGustave FradinCamille Vindras-FouilletJean-François VianOlivier HamantMarie-Thérèse Charreyre
Participatory assessment of minor crops: A situated study on hulled wheats
- Type de publi. : Article dans une revue
- Date de publi. : 04/07/2025
- Auteurs : Sofía CorreaMathieu ThomasJustine LepagneulAubin DémontéC.R. B.A.Pierre BerthetJean-Philippe ClairChristian DalmassoCédric MaryDenis MignardHonorine PérinoMarie-Pierre RépécaudStéphane RouvèsLéa BernardGustave FradinCamille Vindras-FouilletJean-François VianOlivier HamantMarie-Thérèse Charreyre
- Organismes : Reproduction et développement des plantes Ingénierie des Matériaux Polymères Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Amélioration génétique et adaptation des plantes méditerranéennes et tropicales Département Systèmes Biologiques Ingénierie des Matériaux Polymères Reproduction et développement des plantes Agroécologie et Environnement Centre de Ressources de Botanique Appliquée GAEC Ferme des Pierres Gardées Graines de l’Ain Association Régionale pour le Développement de l’Emploi Agricole et Rural Auvergne-Rhône-Alpes Association Régionale pour le Développement de l’Emploi Agricole et Rural Auvergne-Rhône-Alpes Le Croissant Fertile Le Croissant Fertile GAEC Ferme des Pierres Gardées GAEC La Viry Association Régionale pour le Développement de l’Emploi Agricole et Rural Auvergne-Rhône-Alpes Centre d’Ecologie Fonctionnelle et Evolutive Amaranthus Agroécologie et Environnement Reproduction et développement des plantes Ingénierie des Matériaux Polymères
- Publié dans Quantitative Plant Biology le 04/10/2022
Résumé : Expanding crop diversity is essential to address the imminent challenges of agriculture. This is especially true for organic farming, which relies on locally adapted species and varieties. Recently, participatory research approaches have emerged as effective means to support this endeavour. In this study, we collaborated with several stakeholders in the Lyon region, France, to evaluate three minor species related to common wheat (Triticum aestivum subsp . aestivum ): einkorn ( Triticum monococcum subsp . monococcum), emmer (Triticum turgidum subsp . dicoccum) and spelt (Triticum aestivum subsp. spelta (L.) Thell). First, we assessed the agronomic characteristics of each species, highlighting a distinction of einkorn that was associated with high tillering, high protein content, a long phenological cycle, small kernels and low relative yields. Second, we compared intra-species variabilities, revealing greater variation in emmer and spelt. Lastly, outcomes of the participatory approach, including testing adaptive methods and fostering collective learning, may interest other participatory research groups.
Fichiers liés : Correa_a situated study on hulled wheats_QPB 2025.pdf
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Trends in the annual snow melt-out day over the French Alps and Pyrenees from 38 years of high-resolution satellite data (1986–2023)
- Type de publi. : Article dans une revue
- Date de publi. : 04/07/2025
- Auteurs : Zacharie Barrou DumontSimon GascoinJordi IngladaAndreas DietzJonas KöhlerMatthieu LafaysseDiego MonteiroCarlo CarmagnolaArthur BayleJean-Pierre DedieuOlivier HagolleP. Choler
Trends in the annual snow melt-out day over the French Alps and Pyrenees from 38 years of high-resolution satellite data (1986–2023)
- Type de publi. : Article dans une revue
- Date de publi. : 04/07/2025
- Auteurs : Zacharie Barrou DumontSimon GascoinJordi IngladaAndreas DietzJonas KöhlerMatthieu LafaysseDiego MonteiroCarlo CarmagnolaArthur BayleJean-Pierre DedieuOlivier HagolleP. Choler
- Organismes : Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre d'études spatiales de la biosphère Centre National d'Études Spatiales [Toulouse] University Hospital Leipzig = Universitätsklinikum Leipzig Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] Centre d'Etudes de la Neige Centre d'Etudes de la Neige ABEST Horizons Centre d'Etudes de la Neige Laboratoire d'Ecologie Alpine Institut d'Asie Orientale Centre d'études spatiales de la biosphère Centre National d'Études Spatiales [Toulouse] Laboratoire d'Ecologie Alpine
- Publié dans The Cryosphere le 28/10/2020
Résumé : Abstract. Information on the spatial–temporal variability of seasonal snow cover duration over long time periods is critical for studying the responses of mountain ecosystems to climate change. However, this information is often lacking due to the sparse distribution of in situ observations or the lack of adequate remote sensing products. Here, we combined snow cover data from 10 different optical platforms, i.e. SPOT (Satellites Pour l'Observation de la Terre) 1–5, Landsat 5–8, and Sentinel-2A and Sentinel-2B, to build a time series of the annual snow melt-out day (SMOD, i.e. the first day of no snow cover) at 20 m resolution across the French Alps and Pyrenees (43 × 103 km2). We evaluated the pixel-wise accuracy of the computed SMOD using in situ snow measurements at 276 stations. We found that the residuals are unbiased (median error of 1 d) despite a dispersion (RMSE of 28 d), which suggests that this dataset can be used to study SMOD trends after spatial aggregation. We found average reductions of 21.4 d (5.78 d per decade) over the French Alps and 16 d (4.33 d per decade) over the Pyrenees over the period 1986–2023. The SMOD reduction is robust and significant in most parts of the French Alps and can reach 1 month above 3000 m. The trends are less consistent and more spatially variable in the Pyrenees. This dataset is available for future studies of mountain ecosystem changes and is updated every year using Sentinel-2 data.
Fichiers liés : tc-19-2407-2025.pdf
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Monitoring tropical forests with light drones: ensuring spatial and temporal consistency in stereophotogrammetric products
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 04/07/2025
- Auteurs : Nicolas BarbierPierre PlotonHadrien TuletGaëlle ViennoisHugo LeblancBenoit BurbanMaxime Réjou-MéchainPhilippe VerleyJames BallDenis FeurerGrégoire Vincent
Monitoring tropical forests with light drones: ensuring spatial and temporal consistency in stereophotogrammetric products
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 04/07/2025
- Auteurs : Nicolas BarbierPierre PlotonHadrien TuletGaëlle ViennoisHugo LeblancBenoit BurbanMaxime Réjou-MéchainPhilippe VerleyJames BallDenis FeurerGrégoire Vincent
- Organismes : Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Université de Yaoundé I Ecologie des forêts de Guyane Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème Botanique et Modélisation de l'Architecture des Plantes et des Végétations
Résumé : This study benefited from an "Investissement d'Avenir" grant managed by the Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01), via project PHENOBS. We also acknowledge the support of the UE Biodiversa+ BiodivMon program (Project Coforfunc). We are thankful to Ilona Clocher, Jean-Louis Smock, Jean-Yves Goret, Florian Jeanne and Julien Engel for their help with drone data acquisition and/or processing. Access to the Paracou site and infrastructure (https://paracou.cirad.fr) was granted by CIRAD/Ecofog, and we thank Géraldine Derroire and all Phenobs project participants. We are grateful to Raphaël Pélissier for helping in the initial shaping of the Phenobs project and for his continued support.
Fichiers liés : 2025.06.27.661894.full_bioarXiv.pdf
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Diagnostic value of the wnt target and cancer-associated blood biomarker hPG80: ONCOPRO case-control prospective study
- Type de publi. : Article dans une revue
- Date de publi. : 01/07/2025
- Auteurs : Benoit YouSebastien CouraudPhilippe CeruseLionel BadetPhilippe PaparelAlice DurandMarielle GuilletPhilippe MerleGaelle LescuyerCharles-André PhilipFrancois DucrayMathieu PiocheLionel KarlinJean-Christophe LifanteOlivier GlehenPierre-Adrien BolzeMarion ChauvenetCarole Langlois-JacquesFabien SubtilMarie PiecykAurore CarrotDominique JoubertAlexandre PrieurBerengere VireSara CalattiniLea Payen
Diagnostic value of the wnt target and cancer-associated blood biomarker hPG80: ONCOPRO case-control prospective study
- Type de publi. : Article dans une revue
- Date de publi. : 01/07/2025
- Auteurs : Benoit YouSebastien CouraudPhilippe CeruseLionel BadetPhilippe PaparelAlice DurandMarielle GuilletPhilippe MerleGaelle LescuyerCharles-André PhilipFrancois DucrayMathieu PiocheLionel KarlinJean-Christophe LifanteOlivier GlehenPierre-Adrien BolzeMarion ChauvenetCarole Langlois-JacquesFabien SubtilMarie PiecykAurore CarrotDominique JoubertAlexandre PrieurBerengere VireSara CalattiniLea Payen
- Organismes : Institut de Cancérologie des Hospices Civils de Lyon Centre pour l'innovation en cancérologie de Lyon Institut de Cancérologie des Hospices Civils de Lyon Centre pour l'innovation en cancérologie de Lyon Institut de Cancérologie des Hospices Civils de Lyon Centre pour l'innovation en cancérologie de Lyon Institut de Cancérologie des Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Institut de Cancérologie des Hospices Civils de Lyon Institut de Cancérologie des Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Institut de Cancérologie des Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Institut de Cancérologie des Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Institut de Cancérologie des Hospices Civils de Lyon Centre pour l'innovation en cancérologie de Lyon Institut de Cancérologie des Hospices Civils de Lyon Hôpital Femme Mère Enfant [CHU - HCL] Institut de Cancérologie des Hospices Civils de Lyon Institut de Cancérologie des Hospices Civils de Lyon Hôpital Edouard Herriot [CHU - HCL] Institut de Cancérologie des Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Research on Healthcare Performance Institut de Cancérologie des Hospices Civils de Lyon Institut de Cancérologie des Hospices Civils de Lyon Centre Hospitalier Lyon Sud [CHU - HCL] Institut de Cancérologie des Hospices Civils de Lyon Institut de Cancérologie des Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Institut de Cancérologie des Hospices Civils de Lyon Hospices Civils de Lyon Institut de Cancérologie des Hospices Civils de Lyon Institut de Cancérologie des Hospices Civils de Lyon Institut de Cancérologie des Hospices Civils de Lyon Centre pour l'innovation en cancérologie de Lyon Laboratoire de Biologie Médicale MultiSites [Bron]
- Publié dans Biomarker Research le 25/10/2020
Résumé : Abstract Background hPG 80 (circulating progastrin), initially recognized for its oncogenic properties due to its direct link to the Wnt signaling pathway, is secreted by cancer cells and detectable in the blood of cancer patients. The ONCOPRO centralized case-control study (NCT03787056) was designed to prospectively evaluate the diagnostic utility of hPG 80 in patients with 16 different types of cancer. Methods hPG 80 levels were measured in 421 patients with 16 newly diagnosed cancers (median age 65.6 years old) using the DxPG80.Lab kit (Biodena Care). The diagnostic performance of hPG 80 (the primary endpoint) was assessed by comparing baseline hPG 80 levels in cancer patients with those of 330 asymptomatic aged-matched healthy subjects from the general population. Results Between 2018 and 2022, a total of 506 cancer patients were enrolled in the study, with 421 assessable across 16 distinct cancer cohorts. hPG 80 concentrations were significantly higher in cancer patients compared to the healthy population (median 3.8 [IQR: 1.0-11.1] vs. 1.9 [IQR: 0.6–4.2] pM, P < 0.0001). hPG80 levels were not impacted by renal failure, liver dysfunction, or cancer-associated inflammation. The diagnostic accuracy in cancer patients was ROC AUC 0.63, 95% CI = [0.59–0.67]. The highest diagnostic accuracy was seen in patients with lung cancer (AUC 0.75, 95% CI [0.68–0.82]; specificity = 88% for hPG 80 > 7.73 pM in patients aged > 58 years old) and hepatocellular carcinoma HCC (ROC AUC 0.75, 95% CI [0.66-083]; specificity = 88% for hPG 80 > 7.73 pM in patients aged > 58 years old). Conclusions This large prospective study confirms that cancer patients have significantly higher hPG 80 blood concentration compared to the healthy population. Incorporating this straightforward ELISA assay into screening programs is warranted. Trial registration NCT03787056.
Fichiers liés : 40364_2025_Article_793.pdf
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STAGING OF SUICIDALITY IN BIPOLAR DISORDER: FINDINGS FROM THE FACE-BD COHORT (FondaMental Advanced centre of Expertise for Bipolar Disorders)
- Type de publi. : Article dans une revue
- Date de publi. : 01/07/2025
- Auteurs : Anna Maria AuxiliaEmilie OliéJonathan DuboisEnrico CapuzziValérie AubinBruno AouizerateFrank BellivierRaoul BelzeauxCaroline DubertretDominique JanuelEmmanuel HaffenAntoine LefrereAgnès PelletierMircea PolosanRoman ReyP. RouxLudovic SamalinRaymund SchwanMichel WalterAntoine YrondiPierre-Michel LlorcaMarion LeboyerB EtainPhilippe Courtet
STAGING OF SUICIDALITY IN BIPOLAR DISORDER: FINDINGS FROM THE FACE-BD COHORT (FondaMental Advanced centre of Expertise for Bipolar Disorders)
- Type de publi. : Article dans une revue
- Date de publi. : 01/07/2025
- Auteurs : Anna Maria AuxiliaEmilie OliéJonathan DuboisEnrico CapuzziValérie AubinBruno AouizerateFrank BellivierRaoul BelzeauxCaroline DubertretDominique JanuelEmmanuel HaffenAntoine LefrereAgnès PelletierMircea PolosanRoman ReyP. RouxLudovic SamalinRaymund SchwanMichel WalterAntoine YrondiPierre-Michel LlorcaMarion LeboyerB EtainPhilippe Courtet
- Organismes : Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondation FondaMental [Créteil] Institut de Génomique Fonctionnelle Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondazione IRCCS San Gerardo dei Tintori [Monza, Italy] Fondation FondaMental [Créteil] Centre Hospitalier Princesse Grace Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondation FondaMental [Créteil] Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre de Recherche Clinique [Neuilly-sur-Marne] Centre d'Investigation Clinique de Besançon Fondation FondaMental [Créteil] Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive Assistance Publique - Hôpitaux de Marseille Institut de Neurosciences de la Timone Fondation FondaMental [Créteil] Institut Mondor de Recherche Biomédicale CHU Henri Mondor [Créteil] Fondation FondaMental [Créteil] Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] Centre Hospitalier Universitaire [CHU Grenoble] Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Fondation FondaMental [Créteil] Centre Hospitalier le Vinatier [Bron] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation FondaMental [Créteil] Centre de recherche en épidémiologie et santé des populations Centre Hospitalier de Versailles André Mignot Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Université de Lorraine Hopital de Bohars - CHRU Brest Fondation FondaMental [Créteil] Centre Hospitalier Universitaire de Toulouse Fondation FondaMental [Créteil] Toulouse NeuroImaging Center Fondation FondaMental [Créteil] CHU Clermont-Ferrand Institut Pascal Fondation FondaMental [Créteil] CHU Henri Mondor [Créteil] Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] Institut Mondor de Recherche Biomédicale Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle
- Publié dans European Psychiatry le 23/10/2020
Résumé : Introduction: Suicidal behaviors (SB) in bipolar disorder (BD) are major adverse outcomes that may influence disease progression. While staging models exist for psychiatric disorders, none include suicide. This study aims to stratify suicidal risk in BD, propose a staging model for SB, and assess its clinical utility. Methods: Participants from the FondaMental Advanced Center of Expertise for Bipolar Disorder (FACE-BD) cohort were categorised into five stages (St) based on SB: St0 (no suicidal ideation [SI]), St1 (SI but no suicide attempt [SA]), St2a (non-severe/violent SA), St2b (severe /violent SA), and St3 (multiple SAs). Stages were analysed based on demographic, clinical, cognitive, and biological characteristics using logistic regression. Results: Key differences emerged between stages. St1 showed longer untreated illness and higher lability and lower functioning than St0. St2a was linked to anxiety, substance use disorders, and longer disorder duration, while male gender and lithium bitherapy were protective. St2b exhibited shorter untreated illness and higher childhood trauma (CTQ) scores, with male gender and alcohol use as risk factors. St3 was associated with BD-II, alcohol use, longer disorder duration, and more depressive episodes, but less anxiety. No biochemical or cognitive differences were found across stages. The model was significantly associated with SA occurrence (LRT = 28.74, p < 0.0001). Conclusion: This staging model for suicidality in BD provides a multifaceted approach to risk stratification and predictive insights, although further refinement is needed.
Fichiers liés : Auxilia et al 2025.pdf
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V‐ATPases and amino acid catabolism are strongly disturbed in the roots of autophagy mutants in Arabidopsis, impacting water use efficiency and tricarboxylic acid metabolism
- Type de publi. : Article dans une revue
- Date de publi. : 01/07/2025
- Auteurs : Maxence JamesJacques TrouverieBenoit BernayAnne MarmagneFabien ChardonMarin-Pierre GéminPhilippe EtienneCéline Masclaux‐daubresse
V‐ATPases and amino acid catabolism are strongly disturbed in the roots of autophagy mutants in Arabidopsis, impacting water use efficiency and tricarboxylic acid metabolism
- Type de publi. : Article dans une revue
- Date de publi. : 01/07/2025
- Auteurs : Maxence JamesJacques TrouverieBenoit BernayAnne MarmagneFabien ChardonMarin-Pierre GéminPhilippe EtienneCéline Masclaux‐daubresse
- Organismes : Université de Caen Normandie Ecophysiologie Végétale, Agronomie et Nutritions NCS Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Ecophysiologie Végétale, Agronomie et Nutritions NCS Université de Caen Normandie Institut Jean-Pierre Bourgin - Sciences du végétal
- Publié dans The Plant Journal le 26/10/2020
Résumé :Autophagy is essential for homeostasis and nutrient recycling. Its activity increases with aging and in response to deficiencies. The effects of defective autophagy on root metabolism have not yet been described. Addressing this question through root proteome analyses, we found that most V-ATPases were less abundant in the roots of autophagy mutants than in wild type. V-ATPases deficit, associated with lower root water contents and lower nitrate, magnesium, and potassium concentrations, indicated that the disturbance of cellular ion and water management in autophagy mutants was likely related to vacuole function. Isotopic δ 13 C analyses and leaf temperature measurements using thermography showed that water deficit in autophagy mutants was not due to excess transpiration, as the conductance of stomata was reduced in mutants compared to wild type. Many proteins related to the catabolism of amino acids and lipids and the tricarboxylic acid (TCA) cycle were over-abundant in atg mutants. The increase in several proteases that paralleled amino acid catabolism suggested that in the absence of autophagic flux, compensatory processes could be established to degrade proteins, recycle amino acids, and fuel TCA. Whether the V-ATPases defect affects energy metabolism and promotes lipid and amino acid catabolism to compensate and fuel TCA remains to be explored. In conclusion, this report establishes for the first time a correlation between autophagy and vacuole function through V-ATPases, particularly with regard to water and ion management. Additionally, this report shows the exacerbation of amino acid catabolism in relation to the stimulation of the TCA cycle in autophagy mutants.
Fichiers liés : 2025 - James - V‐ATPases and amino acid catabolism are strongly disturbed in the roots of autophagy.pdf
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