Philippe JEAN-PIERRE

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• Type de publi. : Rapport
• Date de publi. : 31/12/2023
• Auteurs : Françoise ClaroPotter LeatitiaAlexandre GirardSidonie CatteauCathy CesariniGaëlle DarmonFlorence Dell’amicoJ. FabreCéline FerlatDelphine GambaianiPhilippe GeniezD. KoelschClaude MiaudPierre MoissonJean-Baptiste SénégasFranck Urtizberea
• Organismes : Patrimoine naturel Muséum national d'Histoire naturelle

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Résumé : Renewed under the Decree of December 30, 2020, the Marine Turtle Observatory of mainland France and St-Pierre-et-Miquelon consists of three Marine Turtle Networks: the Réseau Tortues Marines Atlantique Est (RTMAE) coordinated by the Centre d'Etudes et de Soins pour les Tortues Marines de l'Aquarium La Rochelle, the Réseau Tortues Marines de Méditerranée Française (RTMMF) coordinated by the Société Herpétologique de France and the Réseau Tortues Marines de St-Pierre-et-Miquelon, coordinated by the DTAM. The RTMAE has recorded 98 strandings/accidental captures/entanglements/opportunistic sightings at sea in 2020 and 68 in 2021. The RTMMF recorded 213 strandings/accidental captures/at-sea sightings in 2020, and 67 in 2021. The RTSPM recorded 13 opportunistic sightings at sea in 2021. Four species of sea turtle were observed in 2020 and 2021 on the coast of mainland France: Leatherback turtles (n=66), Loggerhead turtles (n=214), Kemp's ridleys (n=16) and Green turtles (n=3); in 2021, Loggerhead turtles (n=72), Leatherback turtles (n=54), Kemp's ridleys (n=3) and Green turtles (n=1). In Saint-Pierre-et-Miquelon, only Leatherback Turtles were observed. The temporal distribution of strandings recorded on the Channel-Atlantic coast shows a peak in January and February 2020, while in 2021 sightings took place mainly from October to December. On the Mediterranean coast, strandings were mainly recorded between April and August in 2020, and between February and August in 2021. Accidental captures/entanglements were observed throughout the year. On the Channel-Atlantic coast, the standard curved length of Leatherback turtles measured (n=22) averaged 140.6 cm. Loggerhead turtles measured (n=13) had an average curve length of 32.9 cm, while loggerhead turtles measured on the Mediterranean coast (n=65) had an average standard curve length of 52 cm. The main morbidity observed in the Channel-Atlantic region was hypothermia, and it was due to interactions with fishing activities in the Mediterranean.

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Fichiers liés : 20230915_Rapport d'activités OTM 2020-2021_09_01_2024 Final.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 30/12/2023
• Auteurs : Arthur Michon-ColinMarie MetzgerLise BankirCédric GauciMélanie BrunelStéphanie BaronCaroline Prot-BertoyeBénédicte StengelEric ThervetJean-Philippe HaymannJean-Jacques BoffaFrançois VrtovsnikMartin FlamantPascal HouillierDominique PrieMarie CourbebaisseMartin FlamantPascal HouillierJean-Philippe HaymannJean-Jacques BoffaEric ThervetFrançois VrtovsnikBenedicte StengelFrançois VrtovsnikEric DaugasMartin FlamantEmmanuelle Vidal-PetiotNahid TabibzadehChristian JacquotAlexandre KarrasStéphane RoueffEric ThervetPascal HouillierMarie CourbebaisseJean-Philippe BertocchioCaroline Prot-BretoyeJean-Jacques BoffaPierre RoncoH FessiEric RondeauEmmanuel LetavernierJean-Philippe HaymannMarie MetzgerPablo Urena-Torres
• Organismes : Explorations Fonctionnelles Rénales - Physiologie, Hôpital Européen Georges-Pompidou, Assistance Publique - Hôpitaux de Paris, Paris, France
• Publié dans Clinical Kidney Journal le 29/10/2020

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Résumé : ABSTRACT Background Copeptin and intact fibroblast growth factor 23 (iFGF23) increase early during chronic kidney disease (CKD) and may be predictive of unfavourable outcomes. The aim of this study was to evaluate their respective associations with renal and vital outcomes in CKD patients. Methods We included CKD patients from the NephroTest cohort with concomitant measurements of plasma copeptin and iFGF23 concentrations and isotopic glomerular filtration rate measurement (mGFR). The primary endpoint was a composite outcome including kidney failure (KF) (dialysis initiation, pre-emptive transplantation or a 57% decrease of mGFR, corresponding to doubling of serum creatinine) or death before KF. Hazard ratios (HRs) of the primary endpoint associated with log-transformed copeptin and iFGF23 concentrations were estimated by Cox models. The slope of mGFR over time was analysed using a linear mixed model. Results A total of 329 CKD patients (243 men, mean age 60.3 ± 14.6 years) were included. Among them, 301 with an mGFR >15 ml/min/1.73 m2 were included in survival and mGFR slope analyses. During a median follow-up of 4.61 years (quartile 1–quartile 3: 3.72–6.07), 61 KFs and 32 deaths occurred. Baseline iFGF23 concentrations were associated with the composite outcome after multiple adjustments {HR 2.72 [95% confidence interval (CI) 1.85–3.99]}, whereas copeptin concentrations were not [HR 1.01 (95% CI 0.74–1.39)]. Neither copeptin nor iFGF23 were associated with mGFR slope over time. Conclusion Our study shows for the first time in population of CKD patients an independent association between iFGF23 and unfavourable renal and vital outcomes and shows no such association regarding copeptin, encouraging the integration of iFGF23 measurement into the follow-up of CKD.

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Source

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 28/12/2023
• Auteurs : Frédérik OgerCyril BourouhXavier GromadaMaeva MorenoCharlène CarneyEmilie CourtyNabil RabhiEmmanuelle DurandSouhila AmanzougareneLionel BerberianMehdi DerhourhiLaure RollandSarah Anissa HannouPierre-Damien DenechaudZohra BenfoddaPatrick MeffreLluis FajasJulie Kerr-ConteFrançois PattouPhillippe FroguelAmelie BonnefondJean-Sébastien Annicotte
• Organismes : Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Université de Lausanne = University of Lausanne Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Université de Lausanne = University of Lausanne Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Hammersmith Hospital NHS Imperial College Healthcare Institut Européen de Génomique du Diabète - European Genomic Institute for Diabetes - FR 3508 Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Metabolic functional (epi)genomics and molecular mechanisms involved in type 2 diabetes and related diseases - UMR 8199 - UMR 1283

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Résumé : Abstract The loss of pancreatic β-cell identity emerges as an important feature of type 2 diabetes development, but the molecular mechanisms are still elusive. Here, we explore the cell-autonomous role of the cell cycle regulator and transcription factor E2F1 in the maintenance of β-cell identity and insulin secretion. We show that the β-cell-specific loss of E2f1 function in mice triggers glucose intolerance associated with defective insulin secretion, an altered α-to-β-cell ratio, a downregulation of many β-cell genes and a concomitant increase of non-β-cell markers. Mechanistically, the epigenomic profiling of non-beta cell upregulated gene promoters identified an enrichment of bivalent H3K4me3/H3K27me3 or H3K27me3 marks. Conversely, downregulated genes were enriched in active chromatin H3K4me3 and H3K27ac histone marks. We find that histone deacetylase inhibitors modulate E2F1 transcriptional and epigenomic signatures associated with these β-cell dysfunctions. Finally, the pharmacological inhibition of E2F transcriptional activity in human islets also impairs insulin secretion and the expression of β-cell identity genes. Our data suggest that E2F1 is critical for maintaining β-cell identity through a sustained repression of non β-cell transcriptional programs.

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Fichiers liés : 2020.10.14.339929v1.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 26/12/2023
• Auteurs : Félix Camirand-LemyreLaura MersonBharath Kumar Tirupakuzhi VijayaraghavanAidan BurrellBarbara Wanjiru CitarellaMarie-Pier DomingueSimon LévesqueEffua UsufEvert-Jan WilsShinichiro OhshimoIgnacio Martin-LoechesOana SǎndulescuJon Henrik LaakeFrançois LamontagneSheryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelAmal AbrousLara AbsilKamal Abu JabalNashat Abu SalahAndrew AckerElisabeth AdamDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalChika AkwaniEman Al QasimRazi AlalqamAliya Mohammed AlameenAngela AlbertiTala Al-DabbousSenthilkumar AlegesanMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliAdam AliKazali Enagnon AlidjnouQabas AlkhafajeeClotilde AllavenaNathalie AllouJoão AlvesRita AlvesJoão Melo AlvesJoana Alves CabritaMaria AmaralNur AmiraRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise Artaud-MacariAngel AsensioElizabeth AshleyMuhammad AshrafJean Baptiste AssieAmirul AsyrafMinahel AtifAnika AtiqueAm Udara Lakshan AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetEyvind AxelsenLaurène AzemarCecile AzoulayHakeem BabatundeBenjamin BachDelphine BacheletClaudine BadrRoar Bævre-JensenNadia BaigJohn Kenneth BaillieJ Kevin BairdErica BakAgamemnon BakakosNazreen Abu BakarAndriy BalMohanaprasanth BalakrishnanFirouzé Bani-SadrRenata BarbalhoNicholas Yuri BarbosaWendy BarclaySaef Umar BarnettMichaela BarnikelHelena BarrasaCleide BarrigotoMarie BartoliJoaquín BaruchRomain BasmaciMuhammad Fadhli Hassin BasriDenise BattagliniJules BauerDiego Fernando Bautista RinconDenisse Bazan DowAbigail BeaneAlexandra BedossaKer Hong BeeHusna BegumSylvie BehilillAlbertus BeishuizenAleksandr BeljantsevDavid BellemareAnna BeltrameBeatriz Amorim BeltrãoMarine BeluzeNicolas BenechLionel Eric BenjimanSuzanne BennettLuís BentoJan-Erik BerdalDelphine BergeaudHazel BerginJosé Luis Bernal SobrinoGiulia BertoliLorenzo BertolinoSimon BessisSybille BevilcaquaKarine BezulierAmar BhattKrishna BhavsarClaudia BiancoFarah Nadiah BidinFelwa Bin HumaidMohd Nazlin Bin KamarudinZeno BisoffiPatrick BistonLaurent BitkerMustapha BittayeJonathan BittonPablo Blanco-SchweizerCatherine BlierFrank BloosMathieu BlotFilomena BocciaLaetitia BodenesDebby BogaertAnne-Hélène BoivinIsabela BolañosPierre-Adrien BolzeFrançois BompartAurelius BonfasiusDiogo BorgesRaphaël BorieHans Martin BosseElisabeth Botelho-NeversLila BouadmaOlivier BouchaudSabelline BouchezDounia BouhmaniDamien BouhourKevin BouillerLaurence BouilletCamile BouisseLatsaniphone BountthasavongAnne-Sophie BoureauJohn BourkeMaude BouscambertAurore BousquetJason BouziotisMarielle Boyer-BesseyreMaria BoylanFernando Augusto BozzaAxelle BraconnierCynthia BragaTimo BrandenburgerFilipa Brás MonteiroLuca BrazziPatrick BreenDorothy BreenDavid BrewsterKathy BrickellTessa BroadleyHelen BrothertonShaunagh BrowneAlex BrowneNicolas BrozziSonja Hjellegjerde BrunvollMarjolein Brusse-KeizerPetra BrydaNina BuchtelePolina BugaevaMarielle BuissonDanilo BuonsensoErlina BurhanIngrid BustosDenis ButnaruAndré CabieSusana CabralJoana CabritaEder CaceresCyril CadozRui Caetano GarcêsKate CalligyJose Andres CalvacheJoão CamõesValentine CampanaPaul CampbellJosie CampisiCecilia CanepaMireia CanteroJanice CaoiliPauline Caraux-PazSheila CárcelSofia CardosoFilipe CardosoFilipa CardosoNelson CardosoSimone CarelliNicolas CarlierThierry CarmoiGayle CarneyInês CarquejaMarie-Christine CarretFrançois Martin CarrierIda CarrollGail CarsonMaire-Laure CasanovaMariana CascãoSiobhan CaseyJosé CasimiroBailey CassandraSilvia CastañedaNidyanara CastanheiraGuylaine Castor-AlexandreIvo CastroAna CatarinoFrançois-Xavier CatherinePaolo CattaneoRoberta CavalinGiulio Giovanni CavalliAlexandros CavayasAdrian CeccatoMasaneh CeesayMinerva Cervantes-GonzalezMuge CevikAnissa ChairCatherine ChakveatzeAdrienne ChanMeera ChandJean-Marc ChapplainCharlotte CharpentierJulie ChasJonathan Samuel Chávez IñiguezAnjellica ChenYih-Sharng ChenLéo ChenardMatthew Pellan ChengAntoine CheretThibault ChiarabiniJulian ChicaSuresh Kumar ChidambaramLeong Chin ThoCatherine ChirouzeDavide ChiumelloSung-Min ChoBernard CholleyDanoy ChommanamMarie-Charlotte ChopinTing Soo ChowNathaniel ChristyHiu Jian ChuaJonathan ChuaJose Pedro CidadeJosé Miguel Cisneros HerrerosAnna CiulloJennifer ClarkeRolando Claure-del GranadoSara ClohiseyCassidy CodanCaitriona CodyJennifer ColesGwenhaël ColinMichael CollinsPamela CombsJennifer ConnollyMarie ConnorAnne ConradElaine ConwayGraham CookeHugues CordelAmanda CorleySabine CornelisAlexander Daniel CornetArianne Joy CorpuzAndrea CortegianiGrégory CorvaisierCamille CouffignalSandrine Couffin-CadierguesRoxane CourtoisStéphanie CousseRachel CreganCosimo CristellaGloria CrowlJonathan CrumpClaudina CruzJuan Luis Cruz BermúdezJaime Cruz RojoMarc CseteAilbhe CullenMatthew CummingsGerard CurleyElodie CurlierColleen CurranPaula CustodioAna da Silva FilipeCharlene da SilveiraAl-Awwab DabalizAndrew DagensJohn Arne DahlDarren DahlyUmberto d'AlessandroPeter DaleyJo DaltonHeidi DaltonSeamus DalyJuliana DamasNick DanemanEmmanuelle DankwaJorge DantasFrédérick d'AragonMenno de JongGillian de LoughryDiego de MendozaEtienne de MontmollinRafael Freitas de Oliveira FrançaAna Isabel de Pinho OliveiraRosanna de RosaCristina de RoseThushan de SilvaPeter de VriesJillian DeaconDavid DeanAlexa DebardBianca DebenedictisMarie-Pierre DebrayNathalie DecastroWilliam DechertRomain DecoursEve DefousIsabelle DelacroixEric DelaveuveKaren DelavigneNathalie DelfosIonna DeligiannisAndrea Dell'AmoreChristelle DelmasPierre DelobelCorine DelsingElisa DemonchyEmmanuelle DenisDominique DeplanquePieter DepuydtMehul DesaiDiane DescampsMathilde DesvalléesSanti DewayantiPathik DhangarAlpha DialloSylvain DiamantisAndré DiasFernanda Dias da SilvaJuan Jose DiazRodrigo DiazPriscila DiazBakary DibbaKévin DidierJean-Luc DiehlWim DieperinkJérôme DimetVincent DinotFara DiopAlphonsine DioufYael DishonFélix DjossouAnnemarie DochertyHelen DohertyArjen DondorpChristl DonnellySean DonohueYoann DonohuePeter DoranCéline DorivalEric d'OrtenzioYash DoshiPhouvieng DouangdalaJames Joshua DouglasRenee DoumaNathalie DournonJoanne DowneyMark DowningThomas DrakeAoife DriscollAmiel DrorMurray DrydenClaudio Duarte FonsecaVincent Dubée DubéeFrançois DubosAudrey Dubot-PérèsAlexandre DucancelleToni DuculanSusanne DudmanAbhijit DuggalPaul DunandJake DunningMathilde DuplaixEmanuele Durante-MangoniLucian Durham IiiBertrand DussolJuliette DuthoitXavier DuvalAnne Margarita Dyrhol-RiiseSim Choon EanMarco Echeverria-VillalobosMichael EdelsteinSiobhan EganLinn Margrete EggesbøCarla EiraMohammed El SanharawiSubbarao ElapavaluruBrigitte ElharrarJacobien EllerbroekMerete Ellingjord-DaleLoubna ElotmaniPhilippine EloyTarek ElshazlyIqbal ElyazarIsabelle EnderleTomoyuki EndoChan Chee EngIlka EngelmannVincent EnoufOlivier EpaulardMartina EscherMariano EsperattiHélène EsperouCatarina Espírito SantoMarina Esposito-FareseJoão EstevãoManuel EtienneAnna Greti EverdingMirjam EversMarc FabreIsabelle FabreIsmaila FaderaAmna FaheemArabella FahyCameron FairfieldPedro FariaHanan FateenaArie Zainul FatoniKarine FaureRaphaël FavoryMohamed FayedNiamh FeelyJorge FernandesMarília Andreia FernandesSusana FernandesFrançois-Xavier FerrandEglantine Ferrand DevougeJoana FerrãoMário FerrazSílvia FerreiraBernardo FerreiraBenigno FerreiraIsabel FerreiraNicolas FerriereCéline FickoClaudia Figueiredo-MelloWilliam FinlaysonThomas FlamentTom FletcherAline-Marie FlorenceLetizia Lucia FlorioDeirdre FlynnBrigid FlynnJean FoleyVictor FominTatiana FonsecaPatricia FontelaKaren ForrestSimon ForsythDenise FosterGiuseppe FotiErwan FournRobert FowlerMarianne FraherDiego Franch-LlasatJohn FraserChristophe FraserMarcela Vieira FreireAna Freitas RibeiroCaren FriedrichRicardo FritzStéphanie FryNora FuentesMasahiro FukudaArgin GValérie GaborieauRostane GaciMassimo GagliardiJean-Charles GagnardAmandine Gagneux-BrunonAbdou GaiSérgio GaiãoLinda Gail SkeiePhil GallagherCarrol GambleYasmin GaniArthur GaranRebekha GarciaNoelia García BarrioJulia Garcia-DiazEsteban Garcia-GalloNavya GarimellaDenis GarotValérie GarraitAnatoliy GavrylovAlexandre GaymardJohannes GebauerEva GeraudLouis Gerbaud MorlaesNuno GermanoPraveen Kumar GhisulalJade GhosnMarco GianiTristan GiganteElaine GilroyGuillermo GiordanoMichelle GirvanValérie GissotDaniel GlikmanPetr GlybochkoEric GnallGeraldine GocoFrançois GoehringerSiri GoepelJean-Christophe GoffardJin Yi GohJonathan GolobRui GomesKyle GomezJoan Gómez-JunyentMarie GominetAlicia GonzalezPatricia GordonYanay GorelikIsabelle GorenneLaure GoubertCécile GoujardTiphaine GoulenokMargarite GrableJeronimo GrafEdward Wilson GrandinPascal GranierGiacomo GrasselliChristopher GreenCourtney GreeneWilliam GreenhalfSegolène GreffeDomenico Luca GriecoMatthew GriffeeFiona GriffithsIoana GrigorasAlbert GroenendijkHeidi GrunerYusing GuJérémie GuedjMartin GuegoAnne-Marie GuerguerianDaniela GuerreiroRomain GueryAnne GuillaumotLaurent GuilleminaultMaisa Guimarães de CastroThomas GuimardMarieke HaalboomDaniel HaberAli HachemiNadir HadriSheeba HakakAdam HallMatthew HallSophie HalpinAnsley HamerRaph HamersRebecca HamidfarBato HammarströmTerese HammondNaomi HammondLim Yuen HanRashan HaniffaKok Wei HaoHayley HardwickEwen HarrisonJanet HarrisonSamuel Bernard Ekow HarrisonAlan HartmanJunaid HashmiAilbhe HayesLeanne HaysJan HeermanLars HeggelundRoss HendryMartina HennessyAquiles Rodrigo Henriquez-TrujilloMaxime HentzienDiana HernandezDaniel HerrAndrew HersheyLiv HesstvedtAstarini HidayahEibhlin HigginsRupert HigginsSamuel HintonHiroaki HiraiwaHaider HirkaniHikombo HitotoAntonia HoYi Bin HoAlexandre HoctinIsabelle HoffmannWei Han HohOscar HoitingRebecca HoltJan Cato HolterPeter HorbyJuan Pablo HorcajadaIkram HouasCatherine HoughStuart HoulthamJimmy Ming-Yang HsuJean-Sébastien HulotStella HuoAbby HurdSamreen IjazM. Arfan IkramCarlos Cañada IllanaPatrick ImbertHugo InácioCarmen Infante DominguezYun Sii IngElias IosifidisMariachiara IppolitoSarah IsgettTiago IsidoroNadiah IsmailMargaux IsnardMette Stausland IstreJunji ItaiDaniel IvulichDanielle JaafarSalma JaafouraJulien JabotClare JacksonAbubacarr JagneVictoria JanesStéphane JaureguiberryDenise JaworskyFlorence JegoAnilawati Mat JelaniSynne JenumRuth Jimbo-SotomayorOng Yiaw JoeRuth Noemí Jorge GarcíaSilje Bakken JørgensenMark JosephCédric JosephSwosti JoshiMercé JourdainPhilippe JouvetAnna JungHanna JungDafsah JuzarOuifiya KafifFlorentia KaguelidouNeerusha KaisbainThavamany KaleesvranSabina KaliAlina KalicinskaKarl Trygve KallebergSmaragdi KalomoiriMuhammad Aisar Ayadi KamaluddinZul Amali Che KamaruddinNadiah KamarudinDarshana Hewa KandambyKong Yeow KangDyah KanyawatiPratap KarpayahChristiana KartsonakiDaisuke KasugaiKevin KatzChristy KayLamees KayyaliSeán KeatingPulak KediaClaire KellyYvelynne KellyAndrea KellyNiamh KellyAoife KellySadie KellyMaeve KelseyKalynn KennonSommay KeomanyMaeve KernanYounes KerroumiSharma KeshavImrana KhalidAntoine KhalilIrfan KhanKrish KherajaniMichelle KhoSaye KhooRyan KhooDenisa KhooKhor How KiatYuri KidaPeter KiizaBeathe Kiland GranerudAnders Benjamin KildalJae Burm KimAntoine KimmounDetlef Kindgen-MillesNobuya KitamuraEyrun Floerecke Kjetland KjetlandPaul KlenermanRob KlontGry Kloumann BekkenStephen KnightRobin KobbeChamira KodippilyMalte Kohns VasconcelosMamoru KomatsuVolkan KortenArsène KpangonKarolina KrawczykSudhir KrishnanVinothini KrishnanOksana KruglovaPei Xuan KuanDeepali KumarGanesh KumarDinesh KuriakoseEthan KurtzmanNeurinda Permata KusumastutiDemetrios KutsogiannisGalyna KutsynaKonstantinos KyriakoulisMarie LachatreMarie LacosteJohn LaffeyNadhem LafhejMarie LagrangeFabrice LaineOlivier LairezAntonio LaluezaMarc LambertMarie Langelot-RichardVincent LangloisEka Yudha LantangMarina LanzaCédric LaouénanSamira LaribiDelphine LariviereStéphane LasrySakshi LathOdile LaunayDidier LaureillardYoan Lavie-BadieAndy LawTeresa LawrenceCassie LawrenceMinh LeClément Le BihanCyril Le BrisGeorges Le FalherLucie Le FevreQuentin Le HingratMarion Le MaréchalSoizic Le MestreGwénaël Le MoalVincent Le MoingHervé Le NagardEma LealMarta Leal SantosTodd LeeSu Hwan LeeJames LeeHeng Gee LeeBiing Horng LeeYi Lin LeeJennifer LeeGary LeemingLaurent LefebvreBénédicte LefebvreBenjamin LefèvreSylvie LegacJean-Daniel LelievreFrançois LelloucheAdrien LemaignenVéronique LemeeAnthony LemeurGretchen LemminkHa Sha LeneJenny LennonRafael LeónMarc LeoneQuentin LepillerFrançois-Xavier LescureOlivier LesensMathieu LesouhaitierAmy Lester-GrantAndrew LetiziaSophie LetrouYves LevyBruno LevyClaire Levy-MarchalKatarzyna LewandowskaErwan L'HerGianluigi Li BassiJanet LiangGeoffrey LiegeonWei Shen LimKah Chuan LimChantre LimaLim LinaBruno LinaAndreas LindMaja Katherine LingadGuillaume LingasSylvie Lion-DaolioSamantha LissauerKeibun LiuMarine LivrozetPatricia LizotteAntonio LoforteNavy LolongLeong Chee LoonDiogo LopesDalia Lopez-ColonJose Lopez-RevillaAnthony LoschnerPaul LoubetBouchra LouftiGuillame LouisSilvia LourencoLara Lovelace-MaconLee Lee LowMarije LowikJia Shyi LoyJean Christophe LucetCarlos Lumbreras BermejoCarlos LunaOlguta LunguMiles LunnLiem LuongNestor LuqueDominique LutonOlavi MaasikasSara MachadoMoïse MachadoGabriel MachedaGuillermo Maestro de la CalleRafaël MahieuSophie MahyAna Raquel MaiaLars MaierMylène MailletThomas MaitreMaximilian MalfertheinerNadia MalikPaddy MallonFernando MaltezDenis MalvyVictoria MandaJose MandeiLaurent MandelbrotFrank ManettaJulie MankikianEdmund ManningAldric ManuelFlávio MarinoSamuel MarkowiczAna MarquesCatherine MarquisBrian MarshMegan MarshalJohn MarshallCelina Turchi MartelliDori-Ann MartinEmily MartinGuillaume Martin-BlondelF. Eduardo MartinezMartin MartinotAlejandro Martín-QuirosJoão MartinsAna MartinsNuno MartinsCaroline Martins RegoGennaro MartucciOlga MartynenkoEva Miranda MarwaliMarsilla MarzukieDavid MasloveSabina MasonMoshe MatanHenrique Mateus FernandesMathieu MatteiLaurence MaulinJavier MaynarMayfong MayxayThierry MazzoniLisa Mc SweeneyColin McarthurNaina MccannPeter MccannyAnne MccarthyAine MccarthyColin MccloskeyRachael McconnochieSherry McdermottSarah McdonaldAine McelroySamuel McelweeNatalie McevoyAllison McgeerKenneth McleanPaul McnallyBairbre McnicholasEdel MeaneyCécile Mear-PassardMaggie MechlinOmar MehkriFerruccio MeleLuis MeloJoão João MendesOgechukwu MenkitiKusum MenonFrance MentréAlexander MentzerNoémie MercierEmmanuelle MercierAntoine MerckxMayka Mergeay-FabreBlake MerglerAntónio MesquitaRoberta MetaOsama MetwallyAgnès MeybeckDan MeyerAlison MeynertVanina MeysonnierMehdi MezidiCéline MichelangleiIsabelle MicheletEfstathia MihelisVladislav MihnovitJennene MillerHugo Miranda-MaldonadoNor Arisah MisnanTahira Jamal MohamedNik Nur Eliza MohamedAsma MoinElena MolinosBrenda MolloyMary MoneAgostinho MonteiroClaudia MontesGiorgia MontrucchioShona MooreSarah MooreLina Morales CelyLucia MoroBen MortonCatherine MotherwayAna MotosHugo MouquetClara Mouton PerrotJulien MoyetCaroline MudaraNg Yong MuhDzawani MuhamadJimmy MullaertFredrik MüllerKarl Erik MüllerDaniel MunblitLaveena MunshiAisling MurphyPatrick MurrayMarlène MurrisSrinivas MurthyHimed MusaabHimasha MuvindiDimitra Melia MyrodiaBehzad NadjmDave NagpalAlex NagrebetskyMangala NarasimhanNageswaran NarayananAlasdair Nazerali-MaitlandNadège NeantHolger NebNikita NekliudovMatthew NelderErni NelwanRaul NetoEmily NeumannPauline Yeung NgWing Yiu NgAnthony NghiDuc NguyenOrna Ni ChoileainNiamh Ni LeathlobhairAlistair NicholPrompak NitayavardhanaStephanie NonasNurul Amani Mohd NoordinNurul Faten Izzati NorharizamAlessandra NotariMahdad NoursadeghiAdam NowinskiSaad NseirNurnaningsih NurnaningsihDwi Utomo NusantaraElsa NyamankollyAnders Benteson NygaardFionnuala O BrienAnnmarie O CallaghanGiovanna OcchipintiDerbrenn OconnorMax O'DonnellTawnya OgstonTakayuki OguraTak-Hyuk OhSophie O'HalloranKatie O'HearnAgnieszka OldakowskaJoão OliveiraPiero OlliaroDavid OngJee Yan OngWilna OosthuyzenAnne OpavskyPeter OpenshawClaudia Milena Orozco-ChamorroJamel OrtolevaJavier OsatnikLinda O'SheaMiriam O'SullivanSiti Zubaidah OthmanPaul OtikuNadia OuamaraRachida OuissaEric OziolMaïder PagadoyJustine PagesMassimo PalmariniGiovanna PanarelloPrasan Kumar PandaLai Hui PangMauro PanigadaNathalie PansuAurélie PapadopoulosRachael ParkeMelissa ParkerJérémie PasquierBruno PasteneFabian PataunerDrashti PatelMohan Dass PathmanathanLuís PatrãoPatricia PatricioLisa PattersonMical PaulChristelle PaulJorge PaulosWilliam PaxtonJean-François PayenSandra PeakeKalaiarasu PeariasamyMiguel Pedrera JiménezGiles PeekFlorent PeelmanNathan Peiffer-SmadjaVincent PeigneMare PejkovskaPaolo PelosiIthan PeltanRui PereiraDaniel PerezThomas PerpointAntonio PesentiVincent PestreLenka PetrouMichele PetrovicVentzislava Petrov-SanchezFrank Olav PettersenGilles PeytavinOoyanong PhonemixaySoulichanya PhoutthavongMichael PiagnerelliWalter PicardOlivier PiconeMaria De PieroDjura PiersmaCarlos PimentelRaquel PintoCatarina PiresLionel PirothAyodhia PitalokaChiara PiubelliRiinu PiusSimone PivaLaurent PlantierHon Shen PngJulien PoissyRyadh PokeerbuxMaria Pokorska-SpiewakSergio PoliGeorgios PollakisDiane PonscarmeJolanta PopielskaDiego Bastos PortoAndra-Maris PostDouwe PostmaPedro PovoaDiana PóvoasJeff PowisSofia PrapaViladeth PraphasiriSébastien PréauChristian PrebensenJean-Charles PreiserAnton PrinssenMark PritchardGamage Dona Dilanthi PriyadarshaniLucia ProençaSravya PudotaBambang Pujo SemediLuisa QuesadaVilmaris Quinones-CardonaVíctor Quirós GonzálezElse Quist-PaulsenMohammed QuraishiFadi QutishatMaia RabaaChristian RabaudAldo RafaelMarie RafiqMutia RahardjaniRozanah Abd RahmanAhmad Kashfi Haji Ab RahmanFernando RainieriGiri Shan RajahramNagarajan RamakrishnanJosé RamalhoAhmad Afiq RamliBlandine RammaertGrazielle Viana RamosRajavardhan RangappaRitika RanjanChristophe RappAasiyah RashanThalha RashanMenaldi RasminIndrek RätsepCornelius RauTharmini RaviAndre RealStanislas RebaudetSarah RedlBrenda ReeveDag Henrik ReikvamRenato ReisJordi RelloJonathan RemppisMartine RemyHongru RenHanna RenkAnne-Sophie ResseguierMatthieu RevestOleksa RewaLuis Felipe ReyesMaria Ines RibeiroAntonia RicchiutoDavid RichardsonDenise RichardsonLaurent RichierSiti Nurul Atikah Ahmad RidzuanAna RiosAsgar RishuPatrick RispalKarine RissoMaria Angelica Rivera NuñezChiara RobbaAndré RobertoCharles RobertsDavid RobertsonOlivier RobineauAnna RocaFerran Roche-CampoPaola RodariSimão RodeiaBernhard RoesslerClaire RogerPierre-Marie RogerEmmanuel RoilidesAmanda RojekRoberto Roncon-AlbuquerqueMélanie RorizManuel Rosa-CalatravaMichael RoseDorothea RosenbergerAndrea RossaneseMatteo RossettiPatrick RossignolCarine RoyBenoît RozeDesy RusmawatiningtyasClark RussellMaeve RyanSteffi RyckaertAleksander Rygh HoltenIsabela SabaMusharaf SadatValla SahraeiPranya SakiyalakLeonardo SalazarGabriele SalesCharlotte Salmon GandonnièreHélène SalvatorEmely SanchezOlivier SanchezKizy Sanchez de OliveiraAngel Sanchez-MirallesVanessa Sancho-ShimizuGyan SandhuZulfiqar SandhuPierre-François SandrineMarlene SantosShirley Sarfo-MensahBruno Sarmento BanheiroIam Claire E. SarmientoBenjamine SartonAnkana SatyaSree SatyapriyaRumaisah SatyawatiEgle SaviciuteParthena SavvidouYen Tsen SawJustin SchafferTjard SchermerArnaud ScherpereelMarion SchneiderMichael SchwameisGary SchwartzJanet ScottJames Scott-BrownNicholas SedillotTamara SeitzMageswari SelvarajooMalcolm SempleRasidah Bt SenianEric SennevilleClaudia SepulvedaFilipa SequeiraTânia SequeiraAry Serpa NetoPablo Serrano BalazoteEllen ShadowitzSyamin Asyraf ShahidanAnuraj ShankarShaikh SharjeelPratima SharmaCatherine ShawVictoria ShawJohn Robert SheenanRohan ShettyDr. Rajesh Mohan ShettyMohiuddin ShiekhNobuaki ShimeHiroaki ShimizuKeiki ShimizuSally ShrapnelHoi Ping ShumNassima Si MohammedNg Yong SiangJeanne SibiudeBountoy SibounheuangAtif SiddiquiLouise SigfridFatoumata SillahPiret SillaotsCatarina SilvaRogério SilvaMaria Joao SilvaBenedict Sim Lim HengWai Ching SinDario SinattiPunam SinghMahendra SinghPompini Agustina SitompulKarisha SivamVegard SkogenSue SmithBenjamin SmoodCoilin SmythMorgane SnackenDominic SoTze Vee SohLene Bergendal SolbergJoshua SolomonTom SolomonEmily SomersAgnès SommetRima SongMyung Jin SongTae SongJack Song ChiaArne SøraasAlbert SottoEdouard SoumMarta SousaAna Chora SousaMaria Sousa UvaVicente Souza-DantasAlexandra SperryElisabetta SpinuzzaB. Sri DarshanaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherTrude SteinsvikYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelAnca Streinu-CercelAmi StuartDavid StuartRicha SuDecy SubektiGabriel SuenJacky SuenPrasanth SukumarAsfia SultanaCharlotte SummersDubravka SupicDeepashankari SuppiahMagdalena SurovcováAtie SuwartiAndrey SvistunovSarah SyahrinKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziFabio TacconeLysa TaghersetShahdattul Mawarni TaibEwa TalarekSara TalebJelmer TalsmaRenaud TamisierMaria Lawrensia TampubolonKim Keat TanYan Chyi TanHiroyuki TanakaTaku TanakaHayato TaniguchiCoralie TardivonPierre TattevinM Azhari TaufikHassan TawfikTze Yuan TeeJoão TeixeiraSofia TejadaMarie-Capucine TellierSze Kye TeohVanessa TeotonioFrançois TéouléOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAlif Adlan Mohd ThabitZhang Duan ThamSuvintheran ThangaveluElmi TheronV. ThibaultSimon-Djamel ThibervilleBenoît ThillJananee ThirumanickamShaun ThompsonNiamh ThompsonDavid ThomsonEmma ThomsonMathew ThorpeSurain Raaj Thanga ThuraiRyan ThwaitesPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitNoémie TissotFiona ToalJordan Zhien Yang TohMaria TokiKristian TonbySia Loong TonniiMarta TorreMargarida TorresAntoni TorresRosario Maria Torres Santos-OlmoHernando Torres-ZevallosMichael TowersTony TrapaniCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteAlexis TurgeonJean-Marie TurmelLance C.W. TurtleAnders TveitaPawel TwardowskiMakoto UchiyamaPg Ishara UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiMichel VaillantCristinava VajdovicsPiero ValentiniLuís Val-FloresStijn van de VeldeMarcel van den BergeMachteld van der FeltzJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van der WerfLaura van GulikJarne van HattemCarolien van NettenFrank van Someren GréveIlonka van VeenHugo van WilligenNoémie VanelHenk VanoverscheldeMichael VarroneShoban Raj VasudayanCharline VauchyPavan Kumar VechamShaminee VeeranAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJosé Ernesto VidalCésar VieiraJudit VillarPierre-Marc VilleneuveAndrea VilloldoGayatri VishwanathanBenoit VisseauxHannah VisserChiara VitielloManivanh VongsouvathHarald VonkemanFanny VuottoNoor Hidayu WahabSuhaila Abdul WahabNadirah Abdul WahidMarina WainsteinLaura WalshChih-Hsien WangSteve WebbJia WeiKatharina WeilTan Pei WenSanne WesseliusT. Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSue WillemsBailey WilliamsVirginie WilliamsPatricia WilliamsJessica WittmanCalvin WongXin Ci WongYew Sing WongTeck Fung WongNatalie WrightLim Saio XianIoannis XynogalasSiti Rohani Binti Mohd YakopMasaki YamazakiElizabeth YaradYazdan YazdanpanahNicholas Yee Liang HingCécile YelnikChian Hui YeohStephanie YerkovichTouxiong YiayeToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeKai ZacharowskiMasliza ZahidMaram ZahranNor Zaila Binti ZaidanMaria ZambonMiguel ZambranoAlberto ZanellaKonrad ZawadkaNurul ZaynahHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : Université de Sherbrooke = University of Sherbrooke [Sherbrooke] CIC - HEGP Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail
• Publié dans JAMA Network Open le 29/10/2020

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Résumé : Importance Research diversity and representativeness are paramount in building trust, generating valid biomedical knowledge, and possibly in implementing clinical guidelines. Objectives To compare variations over time and across World Health Organization (WHO) geographic regions of corticosteroid use for treatment of severe COVID-19; secondary objectives were to evaluate the association between the timing of publication of the RECOVERY (Randomised Evaluation of COVID-19 Therapy) trial (June 2020) and the WHO guidelines for corticosteroids (September 2020) and the temporal trends observed in corticosteroid use by region and to describe the geographic distribution of the recruitment in clinical trials that informed the WHO recommendation. Design, Setting, and Participants This prospective cohort study of 434 851 patients was conducted between January 31, 2020, and September 2, 2022, in 63 countries worldwide. The data were collected under the auspices of the International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC)–WHO Clinical Characterisation Protocol for Severe Emerging Infections. Analyses were restricted to patients hospitalized for severe COVID-19 (a subset of the ISARIC data set). Exposure Corticosteroid use as reported to the ISARIC-WHO Clinical Characterisation Protocol for Severe Emerging Infections. Main Outcomes and Measures Number and percentage of patients hospitalized with severe COVID-19 who received corticosteroids by time period and by WHO geographic region. Results Among 434 851 patients with confirmed severe or critical COVID-19 for whom receipt of corticosteroids could be ascertained (median [IQR] age, 61.0 [48.0-74.0] years; 53.0% male), 174 307 (40.1%) received corticosteroids during the study period. Of the participants in clinical trials that informed the guideline, 91.6% were recruited from the United Kingdom. In all regions, corticosteroid use for severe COVID-19 increased, but this increase corresponded to the timing of the RECOVERY trial (time-interruption coefficient 1.0 [95% CI, 0.9-1.2]) and WHO guideline (time-interruption coefficient 1.9 [95% CI, 1.7-2.0]) publications only in Europe. At the end of the study period, corticosteroid use for treatment of severe COVID-19 was highest in the Americas (5421 of 6095 [88.9%]; 95% CI, 87.7-90.2) and lowest in Africa (31 588 of 185 191 [17.1%]; 95% CI, 16.8-17.3). Conclusions and Relevance The results of this cohort study showed that implementation of the guidelines for use of corticosteroids in the treatment of severe COVID-19 varied geographically. Uptake of corticosteroid treatment was lower in regions with limited clinical trial involvement. Improving research diversity and representativeness may facilitate timely knowledge uptake and guideline implementation.

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Fichiers liés : camirandlemyre_2023_oi_231358_1702404979.99379.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/12/2023
• Auteurs : Pierre-Antoine RodeschSalim Si-MohamedJérôme LesaintPhilippe DouekSimon Rit
• Organismes : Imagerie Tomographique et Radiothérapie Modeling & analysis for medical imaging and Diagnosis Imagerie Tomographique et Radiothérapie Modeling & analysis for medical imaging and Diagnosis Imagerie Tomographique et Radiothérapie
• Publié dans Physics in Medicine and Biology le 02/11/2020

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Résumé : Abstract Objective . X-ray spectral computed tomography (CT) allows for material decomposition (MD). This study compared a one-step material decomposition MD algorithm with a two-step reconstruction MD algorithm using acquisitions of a prototype CT scanner with a photon-counting detector (PCD). Approach . MD and CT reconstruction may be done in two successive steps, i.e. decompose the data in material sinograms which are then reconstructed in material CT images, or jointly in a one-step algorithm. The one-step algorithm reconstructed material CT images by maximizing their Poisson log-likelihood in the projection domain with a spatial regularization in the image domain. The two-step algorithm maximized first the Poisson log-likelihood without regularization to decompose the data in material sinograms. These sinograms were then reconstructed into material CT images by least squares minimization, with the same spatial regularization as the one step algorithm. A phantom simulating the CT angiography clinical task was scanned and the data used to measure noise and spatial resolution properties. Low dose carotid CT angiographies of 4 patients were also reconstructed with both algorithms and analyzed by a radiologist. The image quality and diagnostic clinical task were evaluated with a clinical score. Main results . The phantom data processing demonstrated that the one-step algorithm had a better spatial resolution at the same noise level or a decreased noise value at matching spatial resolution. Regularization parameters leading to a fair comparison were selected for the patient data reconstruction. On the patient images, the one-step images received higher scores compared to the two-step algorithm for image quality and diagnostic. Significance . Both phantom and patient data demonstrated how a one-step algorithm improves spectral CT image quality over the implemented two-step algorithm but requires a longer computation time. At a low radiation dose, the one-step algorithm presented good to excellent clinical scores for all the spectral CT images.

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Fichiers liés : One_Step_PMB.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/12/2023
• Auteurs : Stephen AlexanderArthur ChristopoulosAnthony DavenportEamonn KellyAlistair MathieJohn PetersEmma VealeJane ArmstrongElena FaccendaSimon HardingJamie DaviesMaria Pia AbbracchioGeorge AbrahamAlexander AgoulnikWayne AlexanderKhaled Al-HosainiMagnus BäckJillian BakerNicholas BarnesRoss BathgateJean‐martin BeaulieuAnnette G Beck-SickingerMaik BehrensKenneth BernsteinBernhard BettlerNigel BirdsallVictoria BlahoFrancois BoulayCorinne BousquetHans Bräuner-OsborneGeoffrey BurnstockGirolamo CalóJusto CastañoKevin CattStefania CerutiPaul ChazotNan ChiangBice ChiniJerold ChunAntonia CianciulliOlivier CivelliLucie ClappRéjean CoutureHelen CoxZsolt CsabaClaes DahlgrenGordon DentSteven DouglasPascal DournaudSatoru EguchiEmanuel EscherEdward FilardoTung FongMarta FumagalliRaul GainetdinovMichael GareljaMarc de GasparoCraig GerardMarvin GershengornFernand GobeilTheodore GoodfriendCyril GoudetLukas GrätzKaren GregoryAndrew GundlachJörg HamannJulien HansonRichard HaugerDebbie HayAkos HeinemannDeron HerrMorley HollenbergNicholas HollidayMastgugu HoriuchiDaniel HoyerLászló HunyadyAhsan HusainAdriaan IjzermanTadashi InagamiKenneth JacobsonRobert JensenRalf JockersDeepa JonnalagaddaSadashiva KarnikKlemens KaupmannJacqueline KempCharles KennedyYasuyuki KiharaTakio KitazawaPawel KozielewiczHans‐jürgen KreienkampJyrki KukkonenTobias LangenhanDan LarhammarKatie LeachDavide LeccaJohn LeeSusan LeemanJérôme LeprinceXaria LiStephen LolaitAmelie LuppRobyn MacraeJanet MaguireDavide MalfaciniJean MazellaCraig McardleShlomo MelmedMartin MichelLaurence MillerVincenzo MitoloBernard MouillacChrista MüllerPhilip MurphyJean‐louis NahonTony NgoXavier NorelDuuamene NyimanuAnne‐marie O’carrollStefan OffermannsMaria Antonietta PanaroMarc ParmentierRoger PertweeJean-Philippe PinEric ProssnitzMark QuinnRithwik RamachandranManisha RayRainer ReinscheidPhilippe RondardG. Enrico RovatiChiara RuzzaGareth SangerTorsten SchönebergGunnar SchulteStefan SchulzDeborah SegaloffCharles SerhanKhuraijam Dhanachandra SinghCraig SmithLeigh StoddartYukihiko SugimotoRoger SummersValerie TanDavid ThalWalter ThomasPieter TimmermansKalyan TirupulaLawrence TollGiovanni TulipanoHamiyet UnalThomas UngerCeline ValantPatrick VanderheydenDavid VaudryHubert VaudryJean‐pierre VilardagaChristopher WalkerJi Ming WangDonald WardHans‐jürgen WesterGary WillarsTom Lloyd WilliamsTrent WoodruffChengcan YaoRichard Ye
• Organismes : University of Nottingham, UK Monash university University of Cambridge [Cambridge, UK] University of Bristol [Bristol] Suffolk University Ninewells Hospital and Medical School [Dundee] University of Dundee University of Greenwich University of Kent [Canterbury] The University of Edinburgh The University of Edinburgh The University of Edinburgh The University of Edinburgh Università degli Studi di Milano = University of Milan University of Cambridge [Cambridge, UK] Florida International University [Miami] Emory University [Atlanta, GA] King Saud University [Riyadh] Défaillance Cardiovasculaire Aiguë et Chronique Karolinska University Hospital [Solna, Sweden] Centre Hospitalier Régional Universitaire de Nancy University of Nottingham, UK University of Birmingham [Birmingham] The Florey Institute of Neuroscience and Mental Health University of Toronto Leipzig University / Universität Leipzig Technische Universität Munchen = Technical University Munich = Université Technique de Munich Cedars-Sinai Medical Center Department of Biomedicine [Basel] Biozentrum [Basel, Suisse] The Francis Crick Institute [London] Sanford Burnham Prebys Medical Discovery Institute Université Grenoble Alpes Centre de Recherches en Cancérologie de Toulouse University of Copenhagen = Københavns Universitet University College London [UCL] Università degli Studi di Padova = University of Padua Universidad de Córdoba = University of Córdoba [Córdoba] National Institutes of Health [Bethesda, MD, USA] Università degli Studi di Milano = University of Milan Durham University Harvard University Università degli Studi di Milano-Bicocca = University of Milano-Bicocca University of California [San Diego] Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro University of California [Irvine] University College London [UCL] Université de Montréal King‘s College London Institut National de la Santé et de la Recherche Médicale Göteborgs Universitet = University of Gothenburg Keele University [Keele] University of Pennsylvania [Philadelphia] Institut National de la Santé et de la Recherche Médicale Temple University [Philadelphia] Université de Sherbrooke = University of Sherbrooke [Sherbrooke] University of Iowa [Iowa City] LabCorp Università degli Studi di Milano = University of Milan Saint Petersburg State University University of Otago [Dunedin, Nouvelle-Zélande] MG Consulting Co [Basel] Harvard University National Institutes of Health [Bethesda, MD, USA] Université de Sherbrooke = University of Sherbrooke [Sherbrooke] University of Wisconsin-Madison Institut de Génomique Fonctionnelle Karolinska Institutet [Stockholm] Monash university The Florey Institute of Neuroscience and Mental Health Universiteit van Amsterdam Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich University of California [San Diego] University of Otago [Dunedin, Nouvelle-Zélande] Universität Graz = University of Graz San Diego State University University of Calgary University of Nottingham, UK Ehime University [Matsuyama, Japon] University of Melbourne Semmelweis University [Budapest] Emory University [Atlanta, GA] Universiteit Leiden = Leiden University Vanderbilt University [Nashville] National Institutes of Health [Bethesda, MD, USA] National Institutes of Health [Bethesda, MD, USA] Institut National de la Santé et de la Recherche Médicale Sanford Burnham Prebys Medical Discovery Institute Lerner Research Institute [Cleveland, OH, USA] Novartis Pharma AG Cleveland Clinic University of Strathclyde [Glasgow] Sanford Burnham Prebys Medical Discovery Institute Rakuno Gakuen University [Japan] Karolinska Institutet [Stockholm] Universität Hamburg = University of Hamburg Helsingin yliopisto = Helsingfors universitet = University of Helsinki Leipzig University / Universität Leipzig Uppsala Universitet [Uppsala] Monash university Università degli Studi di Milano = University of Milan The University of Queensland Boston University [Boston] Neuroendocrine, Endocrine and Germinal Differentiation Communication The University of Queensland University of Bristol [Bristol] Friedrich-Schiller-Universität Jena = Friedrich Schiller University Jena = Université de Iéna [Jena, Germany] University of Cambridge [Cambridge, UK] University of Cambridge [Cambridge, UK] Università degli Studi di Padova = University of Padua Centre National de la Recherche Scientifique University of Bristol [Bristol] Cedars-Sinai Medical Center Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University Mayo Foundation Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro Institut de Génomique Fonctionnelle Universität Bonn = University of Bonn Edge Hill University Institut de pharmacologie moléculaire et cellulaire Sanford Burnham Prebys Medical Discovery Institute Institut National de la Santé et de la Recherche Médicale University of Cambridge [Cambridge, UK] University of Bristol [Bristol] Max Planck Institute for Heart and Lung Research Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro Université libre de Bruxelles = Free University of Brussels University of Aberdeen Institut de Génomique Fonctionnelle The University of New Mexico [Albuquerque] Montana State University University of Calgary Sanford Burnham Prebys Medical Discovery Institute Friedrich-Schiller-Universität Jena = Friedrich Schiller University Jena = Université de Iéna [Jena, Germany] Institut de Génomique Fonctionnelle Università degli Studi di Milano = University of Milan Università degli Studi di Ferrara = University of Ferrara Queen Mary University of London Leipzig University / Universität Leipzig Karolinska Institutet [Stockholm] Friedrich-Schiller-Universität Jena = Friedrich Schiller University Jena = Université de Iéna [Jena, Germany] University of Iowa [Iowa City] Harvard University Cleveland Clinic Deakin University [Waurn Ponds] University of Nottingham, UK Kumamoto University Monash University [Melbourne] University of California [San Diego] Monash University [Melbourne] The University of Queensland Kosan Biosciences Cleveland Clinic Florida Atlantic University [Boca Raton] Università degli Studi di Brescia = University of Brescia Cleveland Clinic Maastricht University [Maastricht] Monash University [Melbourne] Université libre de Bruxelles = Free University of Brussels Université de Rouen Normandie Université de Rouen Normandie University of Pittsburgh University of Auckland [Auckland] National Institutes of Health [Bethesda, MD, USA] University of Manchester [Manchester] Technische Universität Munchen = Technical University Munich = Université Technique de Munich University of Leicester University of Cambridge [Cambridge, UK] The University of Queensland The University of Edinburgh The Chinese University of Hong Kong
• Publié dans British Journal of Pharmacology le 29/10/2020

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Résumé : The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands ( https://www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177 . G protein‐coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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• Type de publi. : Article dans une revue
• Date de publi. : 19/12/2023
• Auteurs : Camille de CevinsLaure DelageMaxime BatignesQuentin RillerMarine LukaAnne RemauryBoris SorinTinhinane FaliCécile MassonBénédicte HoareauCatherine MeunierMélanie ParisotMohammed ZarhrateBrieuc P PérotVíctor García-ParedesFrancesco CarboneLou GalliotBéatrice NalPhilippe PierreLuc CanardCharlotte BoussardÉtienne CrickxJean-Claude GuillemotBrigitte Bader-MeunierAlexandre BelotPierre QuartierMarie-Louise FrémondBénédicte NevenGalina BoldinaFranck AugéFischer AlainMichel DidierFrédéric Rieux-LaucatMickaël Ménager
• Organismes : Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Sanofi Aventis R&D [Chilly-Mazarin] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Cytométrie Pitié-Salpêtrière Cytométrie Pitié-Salpêtrière Structure Fédérative de Recherche Necker Structure Fédérative de Recherche Necker Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Sanofi Aventis R&D [Chilly-Mazarin] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Sanofi Aventis R&D [Chilly-Mazarin] Hôpital Necker - Enfants Malades [AP-HP] Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling [CIRI] Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] Sanofi R&D Data and Data Science, Artificial Intelligence & Deep Analytics, Omics Data Science Sanofi R&D Data and Data Science, Artificial Intelligence & Deep Analytics, Omics Data Science Imagine - Institut des maladies génétiques (IHU) Sanofi Aventis R&D [Chilly-Mazarin] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU)
• Publié dans Cell Reports Medicine le 01/11/2020

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Résumé : Gain-of-function mutations in stimulator of interferon gene 1 (STING1) result in STING-associated vasculopathy with onset in infancy (SAVI), a severe autoinflammatory disease. Although elevated type I interferon (IFN) production is thought to be the leading cause of the symptoms observed in patients, STING can induce a set of pathways, which have roles in the onset and severity of SAVI and remain to be elucidated. To this end, we performed a multi-omics comparative analysis of peripheral blood mononuclear cells (PBMCs) and plasma from SAVI patients and healthy controls, combined with a dataset of healthy PBMCs treated with IFN-β. Our data reveal a subset of disease-associated monocyte, expressing elevated CCL3, CCL4, and IL-6, as well as a strong integrated stress response, which we suggest is the result of direct PERK activation by STING. Cell-to-cell communication inference indicates that these monocytes lead to T cell early activation, resulting in their senescence and apoptosis. Last, we propose a transcriptomic signature of STING activation, independent of type I IFN response.

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 19/12/2023
• Auteurs : Arnaud DieudonnéClément BaillyFlorent CachinAgathe Edet-SansonFrançoise Kraeber-BodéréSébastien HapdeyCharles MerlinPhilippe RobinPierre-Yves SalaunPaul SchwartzDavid TonneletPierre VeraFrédéric CourbonThomas Carlier
• Organismes : Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Equipe Quantification en Imagerie Fonctionnelle Service de Médecine Nucléaire [Nantes] Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Equipe Quantification en Imagerie Fonctionnelle Service de Médecine Nucléaire [Nantes] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Equipe Quantification en Imagerie Fonctionnelle Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Service de médecine nucléaire [Brest] Service de médecine nucléaire [Brest] Service de médecine nucléaire [Bordeaux] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Equipe Quantification en Imagerie Fonctionnelle Institut Universitaire du Cancer de Toulouse - Oncopole Pôle imagerie médicale [CHU Toulouse] Service de Médecine Nucléaire [Nantes]
• Publié dans European Journal of Nuclear Medicine and Molecular Imaging le 30/10/2020

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Fichiers liés : Dieudonné_2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/12/2023
• Auteurs : Florian ReizineNicolas MassartVincent JoussellinAnaïs MachutCharles-Hervé VacheronAnne SaveyArnaud FriggeriAlain LepapeSerge AlfandariAlexandra AllaireAntonio AlvarezAmmenouche NacimLaurent ArgausGérard AudibertCaroline AurelOdile BajoletFrédéric BarbutGenevieve BarjonPatricia BauneSébastien BeagueBassam BeilounyNicolas BeleNicolas BelinCécile BernerdYasmina BerrouaneAziz BerroubaJulie BertrandClaire BianchiSandrine BiangomaFabienne Birot JaulinSeverine BonjeanStéphanie Bordes-CouecouAbdenour BouharaPhilippe BouillardCéline BourigaultSylvie BourzeixSébastien BoutreuxHanene BouzidiJulie BrochartStéphanie BulyezMarie CallanquinNathalie CanuMatthieu CapronDaniel CarbognaniVincent CastelainVincent CataneseIsabelle CattaneoVanessa ChartierGuillaume ChassaingRobert ChaussetMélanie ChauvetFabrice ChopinCatherine ChubilleauCéline ClayerAgnès CohenSylvie ComparotPhilippe CorneMarie-Elisabeth CornesseGaelle CornoEsther CortesPatricia CouroubleChristian CrombeVéronique CurnierMonzer DabbachiCédric DananchéAbla DaroukhDamien DassantMartine DaumasAurélien DauratDominique DeffargesFanny DelangheOlivier DelastreJoel DelhommeJean Paul DéliasMartine DelormeFabienne DerramondFrédérique DiawIsabelle DijolsKamel DjedainiLoic DopeuxSophie DuhooThierry DulacClarisse DupinLaurène DupontMichel DurandIsabelle Durand JolyJean-Yves DusseauPierre Yves EgreteauCarole EldinFlorence EspinasseEric FarfourAbdelhamid FatahYannick FedunLuis FerreiraPierre FillatreToufic FingeVéronique FleurialArnaud FlorentinAgnès FribourgSeverine Gallais-HoffClaude GallandRichard GalliotSylvain GarnierGaelle GasanJulien Gaubert-DuclosValérie GauzereThomas GeffriaudIsabelle GeneauHughes GeorgesSolweig Gerbier ColombanChristophe GiacardiSebastien GibotAudrey GlanardMarion GleizeMarieline GoretMichele GourguesDelphine GrauBéatrice GrisiClotilde GroleauLiliane Grolier-BoisCatherine GuignabertFethi Hadj-SlimaneEmmanuelle HammadCatherine HaondMarie Hélène HausermannFrancoise HayoChristophe HenryAlexandre HerblandJulien HuntzingerHervé HyvernatAlexandre JeanBoris JoliboisSylvie JoronGauthier JulienJean KempfLyes KnaniBéatrice La CombeMarie LabruyereSandrine LacroixBruno LafonKatia LamantPeggy LarroudéAnne LaunoyBernadette LaurentThierry LavigneChristine LawrenceQuoc Vien LeMuriel Le CoqAnne-Sophie Le FlochFanny Le FallBrigitte Le TallecLucie LecoutreStanislas LedochowskiRusel LeonClaire LepouseThomas LescotMélanie LevrardMarie Laure LierAnne LignereuxBenjamin LouartClaire MaheuAurélie MaindronFrancois MallardMarie Reine MallaretBernard MankikianChristiane ManzonPhilippe MardrusJacques MariotAudry MartinEmmanuelle MartinMaelle MartinPascale MartresVirginie MaximeOlivier MeunierElla-Pauline MeyerFerhat MezianiSébastien MoschiettoCéline MullerElodie Munier-MarionCaroline NeulierFrançois NicolasJacques-Yves NizouChristine PalittaMichel PascalOlivier PassouantRené-Gilles PatrigeonFrédérique PavillardSabine PeghaireChristophe PerdrixJean-Sebastien PetitJudith PibreWalter PicardSylvie PicaultSantiago Picos GilJérôme PillotPatrick PinaRémi PlattierLaurent PoironChristian PommierGaël PradelCristian PrelipceanPaul-Simon PugliesiVincent QueneeOlga RaposoEve RemySabine Reynaud DeforgesJean-Christophe RichardSylvie RicomeThomas RimmeleAdrien RobineAnne-Claude RocheLaetitia RohrGwenaël Rolland-JacobAdrien RoquesCatherine RougierJérôme RoustanMélanie Saint-LegerFaouzi SalibaDominique SechaudAmine Si-AliCatherine SimacGeorges SimonMichel SirodotVincent StoeckelPhilippe TagawaMarine TasleFabrice ThiollièreBenoit ThiphagneAurélie Thomas-HervieuFrançois TinturierAlexandre TonnelierAlexandre ToroDavid TranvanDominique TrivierGilles TrochéRémi TrussonLionel UrsuletMarie Laure ValdeyronCatherine ValletVanessa van RossemLaurence VasseMyriam VenelleChristine VenotAntoine Vieillard-BaronJean-François VincentMichel VitrisHussein YassineLassane ZanreCecile Zylberfajn
• Organismes : Hôpital Henry Gabrielle [CHU - HCL] Hôpital Henry Gabrielle [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] Centre International de Recherche en Infectiologie Hôpital Henry Gabrielle [CHU - HCL] Centre International de Recherche en Infectiologie Hôpital Henry Gabrielle [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] Centre International de Recherche en Infectiologie Hôpital Henry Gabrielle [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] Centre International de Recherche en Infectiologie Hydrosciences Montpellier CHU de Montpellier, Service de Prévention des infections et de la Résistance
• Publié dans Critical Care le 31/10/2020

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Résumé : Background Candidemia is a high-risk complication among intensive care unit (ICU) patients. While selective digestive decontamination (SDD) has been shown to be effective in preventing ICU-acquired bacterial secondary infection, its effects on ICU-acquired candidemia (ICAC) remain poorly explored. Therefore, we sought to assess the effects of SDD on ICAC. Method Using the REA-REZO network, we included adult patients receiving mechanical ventilation for at least 48 h from January 2017 to January 2023. Non-parsimonious propensity score matching with a 1:1 ratio was performed to investigate the association between SDD and the rate of ICAC. Results A total of 94 437 patients receiving at least 48 h of mechanical ventilation were included throughout the study period. Of those, 3 001 were treated with SDD and 651 patients developed ICAC. The propensity score matching included 2 931 patients in the SDD group and in the standard care group. In the matched cohort analysis as well as in the overall population, the rate of ICAC was lower in patients receiving SDD (0.8% versus 0.3%; p = 0.012 and 0.7% versus 0.3%; p = 0.006, respectively). Patients with ICAC had higher mortality rate (48.4% versus 29.8%; p < 0.001). Finally, mortality rates as well as ICU length of stay in the matched populations did not differ according to SDD (31.0% versus 31.1%; p = 0.910 and 9 days [5–18] versus 9 days [5–17]; p = 0.513, respectively). Conclusion In this study with a low prevalence of ICAC, SDD was associated with a lower rate of ICAC that did not translate to higher survival.

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Fichiers liés : s13054-023-04775-1.pdf

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• Type de publi. : Autre publication
• Date de publi. : 15/12/2023
• Auteurs : Jérémy BousquetMaxence ChambonPhilippe ColemanRomélien ColavittiFanny GrabiasDenis JouveJean-François LafaixJean LessiEmmanuelle MarcLaurent SeurotLaurence VapailleLaetitia JanicotPierre Bourdon
• Organismes : Centre de Recherches et d’Études Administratives de Montpellier - EA 2038 Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Université d'Artois Université de Bretagne Sud Université de Tours Institut de Recherches sur l'Evolution de la Nation Et de l'Etat Centre de Recherche Droit et Territoire(s) - EA URCA - UFR Droit et science politique Université de Strasbourg Haute Autorité de Santé [Saint-Denis La Plaine] Université de Montpellier Institut de Recherches sur l'Evolution de la Nation Et de l'Etat CY Cergy Paris Université - Faculté de droit Université Paris 1 Panthéon-Sorbonne - UFR Science Politique CY Cergy Paris Université - Faculté de droit

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