Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Pierre GazdaBertrand BaujatJérôme SariniAnne Gomez-BrouchetPierre PhilouzeAntoine Moya-PlanaOlivier MalardNicolas FakhryErwan de MonesRenaud GarrelCyril PageFrançois MouawadEmmanuelle VazDiane EvrardChristine BachXavier DufourYann LelongePhilippe SchultzOlivier MauvaisEsteban BrenetS. VergezSarah Atallah
• Organismes : Centre Hospitalier Universitaire de Toulouse CHU Pitié-Salpêtrière [AP-HP] Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Hospices Civils de Lyon Département de cancérologie cervico-faciale [Gustave Roussy] Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Laboratoire Parole et Langage Hôpital de la Conception [CHU - APHM] Bioingénierie tissulaire Service ORL [Hôpital Gui de Chauliac] CHU Amiens-Picardie Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Faculté de Médecine Henri Warembourg - Université de Lille CHU Tenon [AP-HP] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Hôpital Foch [Suresnes] Laboratoire inflammation, tissus épithéliaux et cytokines [UR 15560] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Mitochondrie, Stress oxydant et Protection musculaire Centre Hospitalier Régional Universitaire de Besançon Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Toulouse CHU Pitié-Salpêtrière [AP-HP]
• Publié dans EJSO - European Journal of Surgical Oncology le 22/10/2020

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Résumé : Introduction Laryngeal chondrosarcoma (LCS) is a rare tumor of slow evolution whose treatment is poorly codified. For a long time, a radical treatment by total laryngectomy (TL) was proposed. More recent studies tend to propose a conservative surgical approach of the larynx. The objective of this study was to compare the overall survival (OS) of total laryngectomized patients (TL+) versus non-laryngectomized patients (TL-). The secondary objectives were to analyse the reoperation free survival (RFS), the total laryngectomy free survival (TLFS) and to identify the preoperative factors leading surgeons to propose TL. Materials and methods A retrospective analysis of prospectively collected incident cases from the REFCOR and NetSarc-ResOs multicenter databases between March 1997 and June 2021 was conducted. A propensity score matching analysis was performed to compare the OS of TL+ and TL-patients. Results 74 patients were included. After propensity score, the 5-year OS of TL+ and TL-patients was comparable (100 %, p = 1). The 5-year RFS rate was 69.2 % (95 % CI [57.5–83.4]) and the 5-year TLFS was 61.7 % (95 % CI [50.4–75.5]). Cricoid involvement greater than 50 % (HR 3.58; IC 95 % [1.61–7.92] p < 0.001), an ASA score of 3 or 4 (HR 5.07; IC 95 % [1.64–15.67] p = 0.009) and involvement of several cartilages (HR 5.26; IC 95 % [1.17–23.6] p = 0.04) are prognostic factors for TL. Dyspnea caused by the tumour is a prognostic factor for reoperation (HR 2.59; IC 95 % [1.04–6.45] p = 0.03). Conclusion These results demonstrate that conservative treatment should be considered as first-line treatment for laryngeal chondrosarcoma.

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• Type de publi. : Ouvrage (y compris édition critique et traduction)
• Date de publi. : 01/02/2024
• Auteurs : Touatia AmraouiEmmanuelle DumasAnne-Marie AdamMarie-José AncelThierry ArgantCyril BazillouFrançois BérardPhilippe BorgardLaurence BrissaudOlivier de CazanoveHélène ChewSerge ColasCatherine CoquidéNicolas DelferrièreDjamila FellagueAlain FerdièreMichel FeugèreFranck GabayetXavier LafonPierre-Antoine LamyJacques MouraretSébastien Nieloud-MüllerJacques PlanchonAgata PoirotFrançois PoplinMarie-Pauline PringalleTony SilvinoYannick TeyssonneyreRobert TurcanVéronique Blanc-BijonEmma Bouvard-MorJean-Paul BravardManon CabanisTassadite CheminBenjamin ClémentJulien CouchetOdile FrancMarie GagnolIsabelle GononJanick Ode-RousselFrédéric Trautmann
• Organismes : Centre Camille Jullian - Histoire et archéologie de la Méditerranée et de l'Afrique du Nord de la protohistoire à la fin de l'Antiquité Institut national de recherches archéologiques préventives Institut de recherche sur l'architecture antique Archéologie et histoire ancienne : Méditerranée - Europe Archéologie, Terre, Histoire, Sociétés [Dijon] Archeodunum Archéologie et Archéométrie Études et valorisations archéologiques Archéologie et Archéométrie Ecole Normale Supérieure Archéologie et Philologie d'Orient et d'Occident Centre Camille Jullian - Histoire et archéologie de la Méditerranée et de l'Afrique du Nord de la protohistoire à la fin de l'Antiquité Musée et sites gallo-romains de Saint-Romain-en-Gal Archéologie et Philologie d'Orient et d'Occident Sorbonne Université Archéologies et Sciences de l'Antiquité Musée d'Archéologie Nationale (Saint-Germain-en-Laye, FRANCE) Institut national de recherches archéologiques préventives Archéologie et Archéométrie Université de Bourgogne Archéologie, Terre, Histoire, Sociétés [Dijon] Université Grenoble Alpes Laboratoire Universitaire Histoire Cultures Italie Europe Archéologie et Archéométrie Institut de recherche sur l'architecture antique Cités, Territoires, Environnement et Sociétés Archéologie et Archéométrie Institut national de recherches archéologiques préventives Archéologie et Archéométrie Institut de recherche sur l'architecture antique Archéologie, Terre, Histoire, Sociétés [Dijon] Forum antique de Bavay, musée archéologique du Département du Nord Association archéologique vauclusienne Archéologie et Archéométrie Musée de Die et du Diois Archéologie et Archéométrie Archeodunum Archéologie et Archéométrie BioArchéologie, Interactions Sociétés Environnements Études et valorisations archéologiques Archéologie et Archéométrie Études et valorisations archéologiques Archéologie et Archéométrie Académie des Inscriptions et Belles-Lettres Centre Camille Jullian - Histoire et archéologie de la Méditerranée et de l'Afrique du Nord de la protohistoire à la fin de l'Antiquité Archéologie et Archéométrie Service archéologique de la ville de Lyon Environnement, Ville, Société Institut national de recherches archéologiques préventives Laboratoire de Géographie Physique et Environnementale Musée des Vans (Ardèche) Laboratoire Chrono-environnement (UMR 6249) Archéologie et Archéométrie Études et valorisations archéologiques Institut national de recherches archéologiques préventives Environnement, Ville, Société Archéologie et Archéométrie Institut national de recherches archéologiques préventives Service Départemental d'Archéologie du Département de l'Allier Centre Camille Jullian - Histoire et archéologie de la Méditerranée et de l'Afrique du Nord de la protohistoire à la fin de l'Antiquité Université de Strasbourg

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Résumé : Ce livre réunit une vingtaine de contributions regroupées dans cinq parties : - De l’atelier à l’objet : artisanats, productions et instrumentum ; - Croyances et cultes ; - Iconographie, épigraphie et archéologie funéraire ; - Habiter et organiser un territoire ; - Décorer un édifice, qui reflètent une grande partie des thèmes de recherche de Jean-Claude Béal à qui ces études sont offertes. Elles sont essentiellement centrées sur la Gaule romaine, et plus marginalement sur les provinces romaines occidentales, à l’image des aires géographiques sur lesquelles il travaille.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Cendrine GodetAnne-Laure BrunFrancis CouturaudFrançois LaurentJean-Pierre FratSylvain Marchand-AdamF. GagnadouxElodie BlanchardCamille TailléBruno PhilippeSandrine HirschiClaire AndréjakArnaud BourdinCécile ChenivesseStéphane DominiqueGilles MangiapanMarlène Murris-EspinFrédéric RivièreGilles GarciaFrançois-Xavier BlancFrançois GoupilAnne Bergeron-LafaurieThomas FlamentPascaline PriouHervé MalJoe de KeizerStéphanie RagotJacques Cadranel
• Organismes : AP-HP - Hôpital Bichat - Claude Bernard [Paris] Université Paris Cité Hôpital Foch [Suresnes] Centre Hospitalier Régional Universitaire de Brest Groupe d'Etude de la Thrombose de Bretagne Occidentale Clinique d'Investigation Clinique Université de Bordeaux Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Universitaire d'Angers Hôpital Haut-Lévêque - CHU de Bordeaux AP-HP - Hôpital Bichat - Claude Bernard [Paris] Physiopathologie et Epidémiologie des Maladies Respiratoires Centre Hospitalier René Dubos [Pontoise] Hôpitaux Universitaires de Strasbourg Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 CHU Amiens-Picardie Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Service de Pneumologie et Immuno-Allergologie [CHU LIlle] Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 CHU Rouen Centre Hospitalier Intercommunal de Créteil Service Pneumologie-Allergologie [CHU Toulouse] Centre de Ressources et de Compétences en Mucoviscidose [CHU Toulouse] Hôpital Côte de Nacre [CHU Caen] Université Paris-Saclay Service de pneumologie et de soins intensifs respiratoires [AP-HP, Hôpital Bicêtre] [Centre de Référence de l'hypertension pulmonaire sévère] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Hôpital Marie-Lannelongue Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d’Investigation Clinique de Nantes ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Centre Hospitalier Le Mans (CH Le Mans) Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Universitaire d'Angers AP-HP - Hôpital Bichat - Claude Bernard [Paris] Université Paris Cité CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) CHU Tenon [AP-HP] Sorbonne Université
• Publié dans Chest le 29/10/2020

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Résumé : Background: One of the major challenges in managing allergic bronchopulmonary aspergillosis (ABPA) remains consistent and reproducible assessment of response to treatment.Research questionWhat are the most relevant changes in computed tomography (CT-scan) parameters over time for assessing response to treatment? Study Design and Methods: In this ancillary study of a randomized clinical trial (NEBULAMB), asthmatic patients with available CT-scan and without exacerbation during a 4-month ABPA exacerbation treatment period (corticosteroids and itraconazole) were included. Changed CT-scan parameters were assessed by systematic analyses of CT-scan findings at initiation (M0) and end of treatment (M4). CT-scans were assessed by two radiologists blinded to the clinical data. Radiological parameters were determined by selecting those showing significant changes over time. Improvement of at least one, without worsening of the others, defined the radiological response. Agreement between radiological changes, clinical and immunologic responses was likewise investigated. Results: Among the 139 originally randomized patients, 132 were included. We identified 5 CT-scan parameters showing significant changes at M4: mucoid impaction extent, mucoid impaction density, centrilobular micronodules, consolidation/ground-glass opacities and bronchial wall thickening (P<0.05). These changes were only weakly associated with one another, except for mucoid impaction extent and density. No agreement was observed between clinical or immunologic and radiological responses, assessed as an overall response, or considering each of the parameters (Cohen’s κ, -0.01 to 0.24). Interpretation: Changes in extent and density of mucoid impactions, centrilobular micronodules, consolidation/ground-glass opacities and thickening of the bronchial walls were found to be the most relevant CT-scan parameters to assess radiological response to treatment. A clinical, immunologic and radiological multidimensional approach should be adopted to assess outcomes, probably with a composite definition of response to treatment.

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Fichiers liés : 2024 Godet et al.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Jean-Yves LefrantDan BenhamouMarc-Olivier FischerRomain PirracchioBernard AllaouchicheSophie BastideMatthieu BiaisAlice BletLionel BouvetOlivier BrissaudSorin BrullXavier CapdevilaNicola ClausenPhilippe CuvillonChristophe DadureJean-Stéphane DavidVictoria EleyPatrice ForgetTomoko FujiiAnne GodierDean GopalanPierre-Grégoire GuinotAhmed HasaninOlivier Joannes-BoyauSébastien KereverEric KipnisRuth LandauMorgan Le GuenMatthieu LegrandEmmanuel LorneFrederic MercierNicolas MongardonSheila Nainan MyatraArmelle Nicolas-RobinMark John PetersHervé QuintardJordi RelloPhilippe RichebéJason Alexander RobertsFilippo SanfilippoAntoine SchneiderMircea T SofoneaMiriam TreggiariFrancis VeyckemansBritta Regli von Ungern-SternbergAhed ZeidanLaurent ZieleskiewiczMarzena ZielinskaAlexandre MilmanAntoine Roquilly
• Organismes : Centre Hospitalier Universitaire de Nîmes Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre] Université Paris-Saclay Institut Aquitain du Coeur [Bordeaux] Clinique Saint Augustin San Francisco General Hospital University of California [San Francisco] Service d'anesthésie-réanimation [Centre Hospitalier Lyon Sud - HCL] HEVA [Lyon] HEVA [Lyon] Centre Hospitalier Universitaire de Bordeaux Hôpital de la Croix-Rousse [CHU - HCL] Hôpital Femme Mère Enfant [CHU - HCL] Centre Hospitalier Universitaire de Bordeaux Mayo Clinic [Jacksonville] Centre Hospitalier Régional Universitaire [Montpellier] Odense University Hospital Centre Hospitalier Universitaire de Nîmes Hôpital Lapeyronie [CHU Montpellier] Hospices Civils de Lyon Royal Brisbane and Women's Hospital [Herston, Queensland, Australia] University of Aberdeen The Jikei University School of Medicine Fondation Ophtalmologique Adolphe de Rotschild University of KwaZulu-Natal [Durban, Afrique du Sud] Université Marie et Louis Pasteur Cairo University Centre Hospitalier Universitaire de Bordeaux Département d’Anesthésie-Réanimation-SMUR [Hôpital Lariboisière] Université Paris Cité Faculté de Médecine Henri Warembourg - Université de Lille Columbia University [New York] Hôpital Foch [Suresnes] University of California [San Francisco] San Francisco General Hospital Clinique du Millénaire - Oc Santé [Montpellier] AP-HP - Hôpital Antoine Béclère [Clamart] Hôpital Henri Mondor Homi Bhabha National Institute Tata Memorial Centre Hôpital Robert Debré Great Ormond Street Hospital for Children [London] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Universitat Internacional de Catalunya [Barcelona] Université de Montréal Royal Brisbane and Women's Hospital [Herston, Queensland, Australia] Policlinico University Hospital Catania Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Yale School of Medicine [New Haven, Connecticut] Hôpital Jeanne de Flandres Perth Children's Hospital [Nedlands, WA, Australia] مستشفى الملك فهد التخصصي بالدمام = King Fahad Specialist Hospital - Dammam Hôpital Nord, Assistance Publique-Hôpitaux de Marseille, Marseille, France CHU Marseille Wrocław Medical University Comité réanimation de la Société française d’anesthésie et de réanimation Service d'anesthésie et réanimation chirurgicale [Nantes]
• Publié dans Anaesthesia Critical Care & Pain Medicine le 27/10/2020

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Résumé : ACCPM has decided to publish the editorial entitled “Reducing the Risks of Nuclear War—The Role of Health Professionals” recently written by Editors in Chief of the most prominent medical journals [1]. In this editorial, the authors highlighted the risk of nuclear war and made the case for supporting efforts to reduce its near-term risks. The Editorial Board (EB) of ACCPM would like to emphasize two key viewpoints: 1) Is it the responsibility of healthcare professionals, especially as members of an Editorial Board, to discuss politics, diplomacy, and military options? Obviously, NO. [...]

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Yannick Le MeitourJean-Philippe FoyMathilde GuinandLucas MichonAndy KarabajakianJérôme FayettePierre SaintignyKarène Mahtouk
• Organismes : Centre de Recherche en Cancérologie de Lyon Centre de Recherche Saint-Antoine Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Dynamiques du Cancer, adaptation et modélisation Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon
• Publié dans Oral Oncology le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Hasnaa BenchorfiSébastien ChenuJ.-R. DuclèreCécile GenevoisMathieu AllixEmmanuel VéronJulie CornetteMaggy ColasV.A.G. RiveraVictor FuertesFrançois BrissetPierre CarlesSamar AoujiPhilippe ThomasYounes MessaddeqGaelle Delaizir
• Organismes : Université Laval [Québec] IRCER - Axe 3 : organisation structurale multiéchelle des matériaux Institut des Sciences Chimiques de Rennes IRCER - Axe 3 : organisation structurale multiéchelle des matériaux IRCER - Axe 3 : organisation structurale multiéchelle des matériaux Conditions Extrêmes et Matériaux : Haute Température et Irradiation Conditions Extrêmes et Matériaux : Haute Température et Irradiation Conditions Extrêmes et Matériaux : Haute Température et Irradiation IRCER - Axe 3 : organisation structurale multiéchelle des matériaux IRCER - Axe 3 : organisation structurale multiéchelle des matériaux Université Laval [Québec] Université Laval [Québec] Institut de Chimie Moléculaire et des Matériaux d'Orsay Institut de Recherche sur les CERamiques Université Laval [Québec] Institut de Chimie de la Matière Condensée de Bordeaux IRCER - Axe 3 : organisation structurale multiéchelle des matériaux Université Laval [Québec] IRCER - Axe 3 : organisation structurale multiéchelle des matériaux
• Publié dans Journal of the European Ceramic Society le 27/10/2020

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Résumé : Glass samples belonging the TeO2 - Ta2O5 Bi2O3 (TTB) system are prepared by conventional melt-quenching technique and corresponding vitreous domain is identified. A crystallization study of 80 10 glass composition versus temperature shows structural transitions from to stabilization an unreported translucent anti-glass phase eventually a fully transparent crystalline ceramic in both visible infrared ranges. The structure microstructure phases characterized Powder X-Ray Diffraction, Electron Back-Scatter Transmission Microscopy Raman spectroscopy. optical properties undoped Er3+-doped also discussed. Up-conversion green emission band that intensity about 2 4 times more intense than ceramic, respectively. Furthermore, large spectral bandwidth 105 nm found sample. advantageous spectroscopic characteristics here, together with good thermal stability these samples, suggest has potential applications as amplification medium for generation ultrashort (femtoseconds) pulses.

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Fichiers liés : Benchorfi et al-2023-Crystallization in the TeO2 - Ta2O5 - Bi2O3 system.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Christian PfisterGwenaelle GravisAude FléchonChristine ChevreauHakim MahammediBrigitte LaguerreAline GuillotFlorence JolyMichel SoulieYves AlloryValentin HarterStéphane CulineGéraldine PignotJean Philippe FendlerLaurent GuyGrégory VerhoestNicolas MottetArnaud DoerflerSophie Abadie LacourtoisieAbde Rahmene AzzouziPierre MongiatLionnel GeoffroisPascal EschwègeFrédéric Di FioreGuilhem RoubaudJean Luc HoepffnerPhilippe BarthelemyHervé LangÉric VoogEric MandronJean Marc TouraniCamille SerrateAlexandre ColauCarolina SaldanaAlexandre de la TailleThierry NguyenFrançois KleinclaussYohan LoriotJacques IraniJean Christophe EymardStéphane LarreOlivier HuillardMarc ZerbibFrédéric RollandJérôme RigaudNadine HouedeStéphane DroupyGeorgina MaloufMorgan RoupretSabine VieillotNicolas LetangTiffen LharidonNicolas GaschignardWerner HilgersJean Louis Davin
• Organismes : Hôpital Charles Nicolle [Rouen] Centre d'Investigation Clinique [CHU Rouen] Institut Paoli-Calmettes Centre de Recherche en Cancérologie de Marseille Département cancer environnement (Centre Léon Bérard - Lyon) Oncopole Claudius Regaud Centre Jean Perrin [Clermont-Ferrand] CRLCC Eugène Marquis Institut de Cancérologie de la Loire Lucien Neuwirth Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Chirurgie Générale et Digestive [Rangueil] Institut Curie - Saint Cloud Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Hopital Saint-Louis [AP-HP] Institut Paoli-Calmettes Service Urologie [CHU Clermont-ferrand] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Régional Universitaire de Besançon Université de Bourgogne Service d'Urologie [CHU Caen] Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Centre de Recherche en Automatique de Nancy CHU Rouen Université de Rouen Normandie Institut Bergonié [Bordeaux] Institut de Cancérologie de Strasbourg Europe Hôpitaux Universitaires de Strasbourg Clinique Victor Hugo [Le Mans] Université Gustave Eiffel - UFR Sciences humaines et sociales Groupe Hospitalier Diaconesses Croix Saint-Simon
• Publié dans Lancet Oncology le 02/11/2020

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Résumé : Background: The optimal perioperative chemotherapy for patients with muscle-invasive bladder cancer is not defined. The VESPER (French Genito-Urinary Tumor Group and French Association of Urology V05) trial reported improved 3-year progression-free survival with dose-dense methotrexate, vinblastine, doxorubicin and cisplatin (dd-MVAC) versus gemcitabine and cisplatin (GC) in patients who received neoadjuvant therapy, but not in the overall perioperative setting. In this Article, we report on the secondary endpoints of overall survival and time to death due to bladder cancer at 5-year follow-up. Methods: VESPER was an open-label, randomised, phase 3 trial done at 28 university hospitals or comprehensive cancer centres in France, in which adults (age ≤18 years and ≤80 years) with primary bladder cancer and histologically confirmed muscle-invasive urothelial carcinoma were randomly allocated (1:1; block size four) to treatment with dd-MVAC (every 2 weeks for a total of six cycles) or GC (every 3 weeks for a total of four cycles). Overall survival and time to death due to bladder cancer (presented as 5-year cumulative incidence of death due to bladder cancer) was analysed by intention to treat (ITT) in all randomly assigned patients. Overall survival was assessed by the Kaplan-Meier method with the treatment groups compared with log-rank test stratified for mode of administration of chemotherapy (neoadjuvant or adjuvant) and lymph node involvement. Time to death due to bladder cancer was analysed with an Aalen model for competing risks and a Fine and Gray regression model stratified for the same two covariates. Results were presented for the total perioperative population and for the neoadjuvant and adjuvant subgroups. The trial is registered with ClinicalTrials.gov, NCT01812369, and is complete. Findings: From Feb 25, 2013, to March 1, 2018, 500 patients were randomly assigned, of whom 493 were included in the final ITT population (245 [50%] in the GC group and 248 [50%] in the dd-MVAC group; 408 [83%] male and 85 [17%] female). 437 (89%) patients received neoadjuvant chemotherapy. Median follow-up was 5·3 years (IQR 5·1-5·4); 190 deaths at the 5-year cutoff were reported. In the perioperative setting (total ITT population), we found no evidence of association of overall survival at 5 years with dd-MVAC treatment versus GC treatment (64% [95% CI 58-70] vs 56% [50-63], stratified hazard ratio [HRstrat] 0·79 [95% CI 0·59-1·05]). Time to death due to bladder cancer was increased in the dd-MVAC group compared with in the GC group (5-year cumulative incidence of death: 27% [95% CI 21-32] vs 40% [34-46], HRstrat 0·61 [95% CI 0·45-0·84]). In the neoadjuvant subgroup, overall survival at 5 years was improved in the dd-MVAC group versus the GC group (66% [95% CI 60-73] vs 57% [50-64], HR 0·71 [95% CI 0·52-0·97]), as was time to death due to bladder cancer (5-year cumulative incidence: 24% [18-30] vs 38% [32-45], HR 0·55 [0·39-0·78]). In the adjuvant subgroup, the results were not conclusive due to the small sample size. Bladder cancer progression was the cause of death for 157 (83%) of the 190 deaths; other causes of death included cardiovascular events (eight [4%] deaths), deaths related to chemotherapy toxicity (four [2%]), and secondary cancers (four [2%]). Interpretation: Our results on overall survival at 5 years were in accordance with the primary endpoint analysis (3-year progression-free survival). We found no evidence of improved overall survival with dd-MVAC over GC in the perioperative setting, but the data support the use of six cycles of dd-MVAC over four cycles of GC in the neoadjuvant setting. These results should impact practice and future trials of immunotherapy in bladder cancer.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Mengjia WangPhilippe CiaisRasmus FensholtMartin BrandtShengli TaoWei LiLei FanFrédéric FrappartRui SunXiaojun LiXiangzhuo LiuHuan WangTianxiang CuiZanpin XingZhe ZhaoWigneron J.-P.
• Organismes : Zhengzhou University Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Københavns Universitet = University of Copenhagen = Université de Copenhague Københavns Universitet = University of Copenhagen = Université de Copenhague College of Urban and Environmental Sciences [Beijing] Qing hua da xue = Tsinghua University = Université Tsinghoua [Beijing] Southwest University [Chongqing] Interactions Sol Plante Atmosphère Beijing Normal University Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Nanjing Forestry University Interactions Sol Plante Atmosphère Qing hua da xue = Tsinghua University = Université Tsinghoua [Beijing] Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Vegetation dynamics in the African continent play an important role in the global terrestrial carbon cycle. Above-ground biomass carbon (AGC) stocks in Africa are sensitive to drought, fires and anthropogenic disturbances, and can be increased from forest restoration and tree plantation. However, there are large uncertainties in estimating changes that have occurred in AGC stocks in Africa over the past decades. Here, we used a microwave remote sensing-based vegetation index named Vegetation Optical Depth produced from X-band observations by INRAE Bordeaux (IB X-VOD) to describe the AGC dynamics in Africa covering recent decades. From 2003 to 2021, African AGC showed a net increase at a rate of +0.06 [+0.04, +0.07] PgC·yr−1 (the range represents the minimum and maximum AGC changes estimated by four calibrations), resulting from a large carbon gain of +0.55 [+0.46, +0.60] PgC·yr−1 during the first decade of the twenty-first century (period 1: 2003–2010) and a much weaker increase of +0.05 [+0.04, +0.07] PgC·yr−1 over the recent decade (period 2: 2013–2021). AGC gains were mainly found in non-forest woody areas, which contributed the most to the AGC changes during 2003–2021. Rainforests showed a minor AGC loss of −0.02 [−0.03, −0.02] PgC·yr−1, which emphasizes the need for forest conservation in Africa. Relationships between the AGC changes and potential forcing climate or anthropogenic variables suggested that human-induced deforestation and water stress (especially the vapor pressure deficit (VPD)) are the most important variables explaining the spatial and temporal AGC variations, respectively. For areas of rainforests, we identified a strong relationship between AGC and VPD (negative), soil moisture (positive) and radiation (positive). For areas of sparse vegetation (mainly located in drylands), AGC changes are largely dominated by changes in the soil water conditions. This study presents a new dataset for monitoring AGC dynamics at a continental scale over recent decades being independent of optical observations, quantifying the impacts of anthropogenic pressure and water stress on aboveground biomass carbon changes.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Teddy NovaisSoraya QassemiPhilippe CestacCécile MccambridgeHélène VillarsBertrand DécaudinMathilde DambrineDominique Huvent-GrelleJean RocheDenis FedericoPierre Krolak-SalmonChristelle Mouchoux
• Organismes : Research on Healthcare Performance Centre Hospitalier Universitaire de Toulouse Pôle pharmacie [CHU Toulouse] Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Pôle pharmacie [CHU Toulouse] Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps Pôle Gériatrie [CHU Toulouse] Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Hôpital des Charpennes [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
• Publié dans International Journal of Clinical Pharmacy le 23/10/2020

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Résumé : Background: Patients with Alzheimer's disease and related dementias and their caregivers can be defined as people with higher risk of developing medication-related problems due to aging and polypharmacy. Aim: To assess the medication exposure of patient with Alzheimer's disease and related dementias and their caregivers. Method: Ancillary cross-sectional study based on baseline medication data of the PHARMAID RCT. The PHARMAID study was a multi-center RCT assessing an integrated pharmaceutical care at a psychosocial program. Older outpatients with Alzheimer's disease and related dementias and their older caregivers were eligible for inclusion. Baseline medication data were used to assess the medication exposure, illustrated by the number of medications, the prevalence of potentially inappropriate medications (PIMs) using the EU(7)-PIM list and the Medication Regimen Complexity Index (MRCI). Results: Seventy-three dyads were included in this ancillary study. The mean numbers (SD) of medications used by patients was 6.8 (2.6) and by caregivers was 4.7 (3.7). Overall, 60.3% of patients used at least one PIM and 47.9% of caregivers. Regarding the medication regimen complexity, the mean MRCI was 16.3(8.1) for patients and 11.3(10.5) for caregivers. Conclusion: The results of this study confirm the relevance of carrying out medication review with patients, but also with their caregivers who can be considered as hidden patients.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Pierre GoudetGuillaume CadiotAnne BarlierEric BaudinFrançoise Borson-ChazotLaurent BrunaudRobert CaiazzoCatherine Cardot-BautersFrédéric CastinettiPhilippe ChansonThomas CunyEric DansinSébastien GaujouxSophie GiraudLionel GroussinMaëlle Le BrasJean-Christophe LifanteMuriel MathonnetLouis de MestierÉric MiralliéFrançois PattouPauline RomanetFrédéric SebagChristophe TresalletDelphine VezzosiThomas WalterAntoine Tabarin
• Organismes : Recherche translationnelle sur le diabète - U 1190 Institut Cochin Recherche translationnelle sur le diabète - U 1190 Hospices Civils de Lyon Centre de Recherche en Cancérologie de Lyon Université Claude Bernard Lyon 1 Hôpital Edouard Herriot [CHU - HCL]
• Publié dans Annales d'Endocrinologie = Annals of Endocrinology le 25/10/2020

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