Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Zhe ZhaoPhilippe CiaisWigneron J.-P.Maurizio SantoroMartin BrandtFritz KleinschrothSimon LewisJerome ChaveRasmus FensholtNadine LaporteDenis Jean SonwaSassan SaatchiLei FanHui YangXiaojun LiMengjia WangLei ZhuYidi XuJiaying HeWei Li
• Organismes : Qing hua da xue = Tsinghua University = Université Tsinghoua [Beijing] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Gamma Remote Sensing Research and Consulting AG IT University of Copenhagen Interactions Sol Plante Atmosphère
• Publié dans One Earth le 13/11/2020

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Résumé : Disturbance, vegetation productivity, and recovery are crucial for aboveground biomass carbon (AGC) dynamics. Here, we use multiple satellite-based datasets to analyze the drivers of AGC dynamics in Central Africa. During 2010-2019, deforestation induced a gross AGC loss of 102.2 +/- 17.1 Tg C year- 1 , which was counterbalanced by an AGC increase of 116.9 +/- 41.1 Tg C year- 1 , leading to a net gain of 14.6 +/- 3.8 Tg C year- 1 . Compared to anthropogenic and soil factors, changes in climate-related factors (e.g., radiation) are more important for the non-deforestation AGC changes. A large AGC increase was found in the northern savannas. In moist forests, strong biomass recovery and growth largely compensated the carbon loss from deforestation and degradation. Considering the increasing resource demand due to rapid population growth, reconciling natural conservation and economic development in Central Africa remains challenging and depends on climate changes and country-specific social-economic conditions.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Cordélia Salomez-IhlStéphane TanguyJean-Pierre AlcarazChloé DavinVictor Pascal-MoussellardMariem JabeurPierrick BedouchLudovic Le HegaratValérie FessardAnne-Louise BlierSylvie HuetPhilippe CinquinFrançois Boucher
• Organismes : Modélisation et Évaluation des données complexes en Santé Publique Modélisation et Évaluation des données complexes en Santé Publique
• Publié dans Mutation Research - Genetic Toxicology and Environmental Mutagenesis le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2024
• Auteurs : Cordélia Salomez-IhlStéphane TanguyJean-Pierre AlcarazChloé DavinVictor Pascal-MoussellardMariem JabeurPierrick BedouchLudovic Le HegaratValérie FessardAnne-Louise BlierSylvie HuetPhilippe CinquinFrançois Boucher
• Organismes : Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Physiologie cardio-Respiratoire Expérimentale Théorique et Appliquée Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Laboratoire de Fougères - ANSES Laboratoire de Fougères - ANSES Laboratoire de Fougères - ANSES Laboratoire de Fougères - ANSES Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525
• Publié dans Mutation Research - Genetic Toxicology and Environmental Mutagenesis le 31/10/2020

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Résumé : Preclinical and clinical studies have shown that molecular hydrogen (H2) has anti-oxidant, anti-inflammatory, and anti-apoptotic properties. Safety data are available in the literature and acute toxicity has been tested in isolated cells and laboratory animals. We have evaluates the genotoxicity of H2 in vivo in rats after 72 h exposure, following the International Council for Harmonization guidelines ICH S2 (R1). The study was conducted on three groups of male Wistar rats: a negative control group, a positive control group receiving methyl methanesulfonate, and a H2-treated group receiving a 3.1% H2 gas mixture for 72 h. Alkaline comet, formamidopyrimidine DNA glycosylase (Fpg)-modified comet and bone marrow micronucleus assays were performed. H2 exposure increased neither comet-tail DNA intensity (DNA damage) nor frequency of "hedgehogs" in blood, liver, lungs, or bronchoalveolar lavage fluid. No increase in Fpg-sensitive sites in lungs, no induction of micronucleus formation, and no imbalance of immature erythrocyte to total erythrocyte ratio (IME%) was observed in rats exposed to H2. The ICH S2 (R1) test-battery revealed no in vivo genotoxicity in Wistar rats after 72 h inhalation of a mixture containing 3.1% H2.

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• Type de publi. : Article dans une revue
• Date de publi. : 31/01/2024
• Auteurs : Pierre-Marie WardynJean-Louis EdmeVirginie de BrouckerNathalie Chérot-KornobisDavid RingevalPhilippe AmouyelAnnie SobaszekLuc DauchetSébastien Hulo
• Organismes : Impact de l'environnement chimique sur la santé humaine - ULR 4483 Centre Hospitalier Régional Universitaire [CHU Lille] Impact de l'environnement chimique sur la santé humaine - ULR 4483 Impact de l'environnement chimique sur la santé humaine - ULR 4483 Centre Hospitalier Régional Universitaire [CHU Lille] Impact de l'environnement chimique sur la santé humaine - ULR 4483 Centre Hospitalier Régional Universitaire [CHU Lille] Impact de l'environnement chimique sur la santé humaine - ULR 4483 Centre Hospitalier Régional Universitaire [CHU Lille] Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre Hospitalier Régional Universitaire [CHU Lille] Impact de l'environnement chimique sur la santé humaine - ULR 4483 Centre Hospitalier Régional Universitaire [CHU Lille] Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre Hospitalier Régional Universitaire [CHU Lille] Impact de l'environnement chimique sur la santé humaine - ULR 4483 Centre Hospitalier Régional Universitaire [CHU Lille]
• Publié dans Journal of Occupational Medicine and Toxicology le 24/10/2020

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Résumé : Abstract Objective To describe the proportions of subjects exposed to crystalline silica and the sectors of activity concerned between 1965 and 2010 in a sample of the general French population. Methods We included 2942 participants aged 40 to 65 years, recruited at random from electoral rolls, from the French general population in the cross-sectional ELISABET study between 2011 and 2013. The proportions of subjects exposed to crystalline silica and their sectors of activity were determined on the basis of their career history and the use of the Matgéné job-exposure matrix. Results In the total sample, occupational exposure to crystalline silica was found for 291 subjects (9.9%) between 1965 and 2010, with a predominance of men (20.2% of exposed subjects among men (282 out of 1394) versus 0.6% among women (9 out of 1548)). The highest proportion of participants exposed to crystalline silica was reached in 1980 with 6.1% and then decreases to 4.4% in 2010. Among men, the most frequently exposed sectors of activity were manufacture of basic metals (41.5% of exposed men (117 out of 282)), specialised construction activities (23.1% of exposed men (65 out of 282)) and construction of buildings (14.2% of exposed men (40 out of 282)). Conclusions Although the proportion of workers exposed to crystalline silica has been decreasing since the 1980s, it is still significant at least until 2010, particularly in the construction sector, and further research is needed to improve the monitoring of workers who are or have been exposed to crystalline silica.

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/01/2024
• Auteurs : Jeremy FraeringVirginie SalnotEmilie-Fleur GautierSem EzinmegnonNicolas ArgyKatell Peoc’hHana ManceauJules AlaoFrançois GuillonneauFlorence Migot-NabiasGwladys I. BertinClaire KamaliddinAgnes AubouyDissou AffolabiBibiane BiokouMichel CotJean-Eudes DegbeloPhilippe DeloronLatifou DramaneJean-François FaucherEmilie GuillochonLudivine HouzeSayeh Jafari-GuemouriSandrine HouzéValentin JosteAnaïs LabrunieYélé LadipoThomas LathiereAchille MassougbodjiAudrey MowendabekaJade PapinBernard PipyPierre-Marie PreuxMarie RaymondeauJade RoyoDarius SossouBrigitte TecherBertin Vianou
• Organismes : Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Institut Cochin Plateforme protéomique 3P5 [Institut Cochin] Laboratoire d'Excellence : Biogenèse et pathologies du globule rouge Plateforme protéomique 3P5 [Institut Cochin] Institut Cochin Institut de Biologie Intégrative de la Cellule Groupe de recherche action en santé AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre de recherche sur l'Inflammation Université Paris Cité Centre de recherche sur l'Inflammation AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune Plateforme protéomique 3P5 [Institut Cochin] Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Cumming School of Medicine [Calgary] Pharmacochimie et Biologie pour le Développement Institut de Recherche Clinique du Bénin [Abomey-Calavi, Bénin] Laboratoire de Référence des Mycobactéries [Cotonou, Benin] Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Institut de Recherche Clinique du Bénin [Abomey-Calavi, Bénin] Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Institut de Recherche Clinique du Bénin [Abomey-Calavi, Bénin] Epidémiologie des Maladies Chroniques en zone tropicale Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Nuclear Medicine Department [Hôpital Bichat - Claude Bernard] Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Epidémiologie des Maladies Chroniques en zone tropicale Centre Hospitalier Universitaire de la Mère et de l'Enfant Lagune Service d'Ophtalmologie [CHU Limoges] Institut de Recherche Clinique du Bénin [Abomey-Calavi, Bénin] CHU Limoges Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Centre Hospitalier Universitaire de Zone d'Abomey Calavi / Sô-Ava Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Centre Hospitalier Universitaire de Zone d'Abomey Calavi / Sô-Ava Institut de Recherche Clinique du Bénin [Abomey-Calavi, Bénin] Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Institut de Recherche Clinique du Bénin [Abomey-Calavi, Bénin]
• Publié dans EMBO Molecular Medicine le 23/10/2020

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Résumé : Abstract Cerebral malaria (CM), the most lethal complication of Plasmodium falciparum severe malaria (SM), remains fatal for 15–25% of affected children despite the availability of treatment. P. falciparum infects and multiplies in erythrocytes, contributing to anemia, parasite sequestration, and inflammation. An unbiased proteomic assessment of infected erythrocytes and plasma samples from 24 Beninese children was performed to study the complex mechanisms underlying CM. A significant down-regulation of proteins from the ubiquitin–proteasome pathway and an up-regulation of the erythroid precursor marker transferrin receptor protein 1 ( TFRC ) were associated with infected erythrocytes from CM patients. At the plasma level, the samples clustered according to clinical presentation. Significantly, increased levels of the 20S proteasome components were associated with SM. Targeted quantification assays confirmed these findings on a larger cohort ( n = 340). These findings suggest that parasites causing CM preferentially infect reticulocytes or erythroblasts and alter their maturation. Importantly, the host plasma proteome serves as a specific signature of SM and presents a remarkable opportunity for developing innovative diagnostic and prognostic biomarkers.

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• Type de publi. : Article dans une revue
• Date de publi. : 30/01/2024
• Auteurs : Philippe DamierBertrand DegosGiovanni CastelonovoMathieu AnheimIsabelle BenatruNicolas CarrièreOlivier ColinLuc DefebvreMarie DeverdalAlexandre EusebioVanessa FerrierCaroline GiordanaJean-Luc HouetoSeverine Le DilyMarie MonginClaire ThiriezChristine TranchantDenis RavelJean-Christophe CorvolOlivier RascolYehezkel Ben Ari
• Organismes : Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Hôpital Avicenne [AP-HP] Centre Hospitalier Universitaire de Nîmes Service de Neurologie [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Institut de Génétique et de Biologie Moléculaire et Cellulaire CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Lille Neurosciences & Cognition - U 1172 Centre Hospitalier de Brive-la-Gaillarde Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre Hospitalier Universitaire de Nîmes Aix Marseille Université Service de Neurologie [CHU Nice] Service de Neurologie [CHU Nice] Epidémiologie des Maladies Chroniques en zone tropicale Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Nantes Université Sorbonne Université Service de Neurologie [CHU Caen] Service de Neurologie [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Institut de Génétique et de Biologie Moléculaire et Cellulaire CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université Institut du Cerveau = Paris Brain Institute Centre Hospitalier Universitaire de Toulouse
• Publié dans Movement Disorders le 31/10/2020

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Résumé : Background :Acting on the main target of dopaminergic cells, the striatal γ-aminobutyric acid (GABA)-ergic cells, might be a new way to treat persons with Parkinson's disease (PD).Objective :The objective of this study was to assess the efficacy of bumetanide, an Na–K–Cl cotransporter (NKCC1) inhibitor, to improve motor symptoms in PD.Methods :This was a 4-month double-blind, randomized, parallel-group, placebo-controlled trial of 1.75 to 3 mg/day bumetanide as an adjunct to levodopa in 44 participants with PD and motor fluctuations.Results :Compared to the baseline, the mean change in OFF Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III score after 4 months of treatment (primary endpoint) did not improve significantly compared with placebo. No changes between participants treated with bumetanide and those treated with placebo were observed for most other outcome measures. Despite no relevant safety signals, bumetanide was poorly tolerated.Conclusions :There was no evidence in this study that bumetanide has efficacy in improving motor symptoms of PD. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Fichiers liés : A Double‐Blind Randomized Placebo‐Controlled Trial of Bumetanide in Parkinson s.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/01/2024
• Auteurs : Armelle GUENEGOU ARNOUXJuliette MurrisStephane BéchetCamille JungJohann AuchabieJulien DupeyratNadia AnguelPierre AsfarJulio BadieDorothée CarpentierBenjamin ChoustermanJeremy BourenneAgathe DelboveJérôme DevaquetNicolas DeyeGuillaume DumasAnne-Florence DureauJean-Baptiste LascarrouStephane LegrielChristophe GuittonCaroline Jannière-NarteyJean-Pierre QuenotJean-Claude LacheradeJulien MaizelArmand Mekontso-DessapBruno MourvillierPhilippe PetuaGaëtan PlantefèveJean-Christophe RichardAlexandre RobertClément SaccheriLy van Phach VongSandrine KatsahianFrédérique Schortgen
• Organismes : CIC - HEGP Unité de Recherche Clinique et Centre Investigation Clinique-Epidémiologie Health data- and model- driven Knowledge Acquisition PIERRE FABRE Université Paris Cité Association Clinique et Thérapeutique Infantile du Val de Marne Centre Hospitalier Intercommunal de Créteil Centre Hospitalier de Cholet Centre Hospitalier de Cholet Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre] Centre Hospitalier Universitaire d'Angers Hôpital Nord Franche-Comté [Hôpital de Trévenans] CHU Rouen Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [AP-HP] Hôpital de la Timone [CHU - APHM] Centre hospitalier Bretagne Atlantique (Morbihan) Hôpital Foch [Suresnes] Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière] Hôpital Michallon Groupe hospitalier de la région de Mulhouse et Sud-Alsace Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de réanimation [CH Versailles] Service Réanimation médico-chirurgicale [CH Le Mans] Centre Hospitalier Libourne Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Médecine Intensive-Réanimation [CHU Amiens] CHU Henri Mondor [Créteil] Hôpital universitaire Robert Debré [Reims] Centre Hospitalier de Bigorre [Tarbes] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Université de Lyon Hôpital Pasteur [Nice] Centre Hospitalier Universitaire de Nice Grand Hôpital de l'Est Francilien Health data- and model- driven Knowledge Acquisition CIC - HEGP Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Centre Hospitalier Intercommunal de Créteil
• Publié dans BMJ Open le 26/10/2020

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Résumé : Introduction Fever treatment is commonly applied in patients with sepsis but its impact on survival remains undetermined. Patients with respiratory and haemodynamic failure are at the highest risk for not tolerating the metabolic cost of fever. However, fever can help to control infection. Treating fever with paracetamol has been shown to be less effective than cooling. In the SEPSISCOOL pilot study, active fever control by external cooling improved organ failure recovery and early survival. The main objective of this confirmatory trial is to assess whether fever control at normothermia can improve the evolution of organ failure and mortality at day 60 of febrile patients with septic shock. This study will compare two strategies within the first 48 hours of septic shock: treatment of fever with cooling or no treatment of fever. Methods and analysis SEPSISCOOL II is a pragmatic, investigator-initiated, adaptive, multicentre, open-label, randomised controlled, superiority trial in patients admitted to the intensive care unit with febrile septic shock. After stratification based on the acute respiratory distress syndrome status, patients will be randomised between two arms: (1) cooling and (2) no cooling. The primary endpoint is mortality at day 60 after randomisation. The secondary endpoints include the evolution of organ failure, early mortality and tolerance. The target sample size is 820 patients. Ethics and dissemination The study is funded by the French health ministry and was approved by the ethics committee CPP Nord Ouest II (Amiens, France). The results will be submitted for publication in peer-reviewed journals. Trial registration number NCT04494074 .

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Fichiers liés : e069430.full.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/01/2024
• Auteurs : Luc DesmedtMatthieu RaymondAurélie Le ThuautPierre AsfarCédric DarreauFlorian ReizineGwenhaël ColinJohann AuchabieJulien LorberBéatrice La CombePierre KergoatBaptiste HourmantAgathe DelboveAurélien FrérouJean MorinPierre Yves ErgreteauPhilippe SeguinMaëlle MartinJean ReignierJean-Baptiste LascarrouEmmanuel Canet
• Organismes : Hôpital Hôtel-Dieu [CHU Nantes] CEA Le Ripault Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire d'Angers Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon After ROSC research network [Paris, France] Centre Hospitalier de Cholet Centre Hospitalier de Lorient Centre hospitalier Bretagne Atlantique (Morbihan) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Université de Rennes - Faculté des sciences pharmaceutiques et biologiques Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Background - Recent studies identified coronavirus disease 2019 (COVID-19) as a risk factor for invasive pulmonary aspergillosis (IPA) but produced conflicting data on IPA incidence and impact on patient outcomes. We aimed to determine the incidence and outcomes of COVID-19-associated pulmonary aspergillosis (CAPA) in mechanically ventilated patients. Methods - We performed a multicenter retrospective observational cohort study in consecutive adults admitted to 15 French intensive care units (ICUs) in 2020 for COVID-19 requiring mechanical ventilation. CAPA was diagnosed and graded according to 2020 ECMM/ISHAM consensus criteria. The primary objective was to determine the incidence of proven/probable CAPA, and the secondary objectives were to identify risk factors for proven/probable CAPA and to assess associations between proven/probable CAPA and patient outcomes. Results - The 708 included patients (522 [73.7%] men) had a mean age of 65.2 ± 10.8 years, a median mechanical ventilation duration of 15.0 [8.0-27.0] days, and a day-90 mortality rate of 28.5%. Underlying immunosuppression was present in 113 (16.0%) patients. Corticosteroids were used in 348 (63.1%) patients. Criteria for probable CAPA were met by 18 (2.5%) patients; no patient had histologically proven CAPA. Older age was the only factor significantly associated with probable CAPA (hazard ratio [HR], 1.04; 95% CI 1.00-1.09; P = 0.04). Probable CAPA was associated with significantly higher day-90 mortality (HR, 2.07; 95% CI 1.32-3.25; P = 0.001) but not with longer mechanical ventilation or ICU length of stay. Conclusion - Probable CAPA is a rare but serious complication of severe COVID-19 requiring mechanical ventilation and is associated with higher day-90 mortality.

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Fichiers liés : s13613-023-01229-3.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/01/2024
• Auteurs : Gabriel MenneratLaurent BizetBenoît MahieuAlexandre DobrocDominique LupinskiDenis BalitskyPhilippe VillevalMagali LozanoFatima AlahyaneAurélien HouardJean-Pierre Wolf
• Organismes : Centre d'études scientifiques et techniques d'Aquitaine (CESTA-CEA) Laboratoire Interactions, Dynamiques et Lasers (ex SPAM) Serveurs Laser Laboratoire d'Optique Appliquée Interaction Laser-Matière Laboratoire d'Optique Appliquée Interaction Laser-Matière Cristal Laser Cristal Laser Cristal Laser Cristal Laser Laboratoire d'Optique Appliquée Interaction Laser-Matière Laboratoire d'Optique Appliquée Interaction Laser-Matière Laboratoire d'Optique Appliquée Interaction Laser-Matière Group of Applied Physics [Geneva]

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Résumé : We report on high average-power, high-energy picosecond fourth-harmonic generation in LBO. The first stages of a Yb:YAG laser chain operating at 1 kHz repetition rate generate few-picosecond 220 mJ chirped pulses at 1030 nm fundamental wavelength. They are frequency-converted in a cascade of three LBO crystals to generate the second-, third-, and fourth harmonics at 515 nm, 343 nm and 257 nm respectively. Crystals thicknesses and angular phase matching detuning were calculated as a function of pulse duration through broadband nonlinear optical numerical simulations. Last crystal is both conduction-cooled on edge and surface-cooled at center through forced-air flow to mitigate heating due to nonlinear absorption in the deep-UV and reduce temperature gradients. Chirped-pulse duration was experimentally adjusted to achieve stable 20% overall conversion efficiency. Near-field beam profiles were continuously recorded at 10 Hz, for all four wavelengths involved, together with corresponding energies, showing no significant beam degradation over 50 hours. Temperatures of the two last crystals were monitored and will help optimize surface cooling for future power ramping-up.

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Fichiers liés : Proceedings12869-40 - 45 W average-power, high-energy deep-UV generation at 257 nm in LBO.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/01/2024
• Auteurs : Yara SaadeOmar DerazEirini ChatzopoulouHélène RangéPierre BoutouyrieMarie -Cecile PerierCatherine GuiboutFrédérique ThomasNicolas DanchinXavier JouvenPhilippe BouchardJean‐philippe Empana
• Organismes : Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Paris-Centre de Recherche Cardiovasculaire Pathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies Pathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies Fonctions oncogéniques de la signalisation beta-caténine dans le foie = Oncogenic funtions of beta-catenin signaling in the liver [CRC] Nutrition, Métabolismes et Cancer Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Département d’Oncologie Médicale [IPC, Marseille] Paris-Centre de Recherche Cardiovasculaire Pathologies, imagerie et biothérapies oro-faciales = Orofacial pathologies, imaging and biotherapies Paris-Centre de Recherche Cardiovasculaire
• Publié dans Community Dentistry and Oral Epidemiology le 30/10/2020

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Résumé : Objectives: To examine the association between life-course body silhouette changes and oral conditions in adulthood.Methods: At study recruitment (2008-2012), 5430 adults underwent a full-mouth clinical examination and recalled their body silhouettes at ages 8, 15, 25, 35 and 45. Life-course trajectories of body silhouettes were computed using group-based trajectory modelling. Gingival inflammation, dental plaque, masticatory units, numbers of healthy, missing, decayed and filled teeth at study recruitment were clustered. The associations between body silhouette trajectories and clusters of oral conditions were assessed by multinomial logistic regression.Results: The final analysis included 4472 participants. Five body silhouette trajectories were established: lean-stable (30.0%), lean-increased (19.3%), moderate stable (18.1%), lean-marked increased (25.8%) and heavy stable (6.7%). Three clusters of oral conditions were identified: optimal oral health and preserved masticatory capacity (70.0%, cluster 1), moderate oral health and moderately impaired masticatory capacity (25.4%, cluster 2) and poor oral health and severely impaired masticatory capacity (4.7%, cluster 3). Participants with a lean-increased trajectory were 58% more likely than those with a lean-stable trajectory to be in cluster 3 (aOR 1.58 [95% CI 1.07; 2.35]) relative to cluster 1, independently of covariates measured at study recruitment and including age, sex, smoking, socioeconomic status, BMI, hypertension, type 2 diabetes, cholesterol and triglycerides.Conclusions: A life-course lean-increased body silhouette trajectory is associated with higher likelihood of poor oral health and severely impaired masticatory capacity in adulthood.

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