Philippe Jean-Pierre

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/06/2025
• Auteurs : Laurent MazenqPierre-François CalmonAdrian LabordeFranck CarcenacAurélie LecestreLudovic SalvagnacPascal DubreuilÉric ImbernonDavid BourrierHugues GranierLiviu NicuPhilippe MeniniGuilhem LarrieuPierre JosephMorgan Delarue
• Organismes : Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Service Techniques et Équipements Appliqués à la Microélectronique Laboratoire d'analyse et d'architecture des systèmes Équipe MICrosystèmes d'Analyse Laboratoire d'analyse et d'architecture des systèmes Équipe Micro-Nanofluidique pour les sciences de la vie et de l’environnement Équipe Micro-Nanofluidique pour les sciences de la vie et de l’environnement

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Résumé : This presentation will show how established micro- and nanofabrication techniques contribute to progress in electronics, sensing technologies, and medical applications. After introducing the cleanroom environment, essential for controlling contamination and ensuring high-precision fabrication, it will highlight versatile processes for creating thin films, patterning materials, and defining structures at micro- and nanoscales. The talk will showcase advanced lithography and etching techniques that enable the miniaturization of components, unlocking new possibilities for high-performance devices. Examples of ongoing projects, such as the development of sensitive gas sensors for environmental and health applications, will illustrate the transition from fabrication processes to real-world solutions. Finally, an overview of current research will demonstrate how micro- and nanotechnologies are evolving to meet the demands of future applications, particularly in life sciences and cancer diagnostics, paving the way for smarter, more efficient, and more integrated devices.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 30/06/2025
• Auteurs : Mohamed Amine El YagoubyPhilippe MulhemJean-Pierre ChevalletÉric Gaussier
• Organismes : Laboratoire Lorrain de Recherche en Informatique et ses Applications Université de Lorraine Modélisation et Recherche d’Information Multimédia [Grenoble] Modélisation et Recherche d’Information Multimédia [Grenoble] Laboratoire d'Informatique de Grenoble Centre National de la Recherche Scientifique Laboratoire d'Informatique de Grenoble Université Grenoble Alpes Modélisation et Recherche d’Information Multimédia [Grenoble] Université Grenoble Alpes Laboratoire d'Informatique de Grenoble

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Résumé : Cet article introduit un nouveau cadre d'évaluation pour les systèmes RAG, en comblant les lacunes des approches précédentes. La première phase consiste à concevoir un ensemble de données avec des parties pertinentes extraites pour chaque exemple, représentant les informations nécessaires pour répondre à une question donnée, et à proposer une métrique d'évaluation pour les systèmes IR basée sur la présence de ces parties dans le contenu récupéré. La deuxième phase explore la relation entre le système de RI et les évaluations RAG globales et utilise cette relation pour prédire les performances globales du RAG à partir des performances du SRI. Cette approche élimine le besoin de réponses coûteuses générées par LLM et d'évaluations ultérieures, réduisant ainsi les coûts et fournissant un cadre d'évaluation plus complet et plus robuste pour les systèmes RAG.

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Fichiers liés : CORIA-TALN_2025_paper_153.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 28/06/2025
• Auteurs : Audrey OnfroyFrancette Jean-LouisP. Le CorvoisierFanny CoulpierKevin MuretEric BonnetRaphaele ArrouasseCaroline BoucleSalwa AbidÉmilie SbidianChristina BergqvistPierre WolkensteinVeronique GodotJean‐françois DeleuzeYves LévyPiotr TopilkoÉtienne AudureauSophie Hüe
• Organismes : Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Institut National de la Santé et de la Recherche Médicale Institut Mondor de Recherche Biomédicale Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Institut National de la Santé et de la Recherche Médicale Institut National de la Santé et de la Recherche Médicale Institut Mondor de Recherche Biomédicale Institut National de la Santé et de la Recherche Médicale Epidemiology in Dermatology and Evaluation in Therapeutics Epidemiology in Dermatology and Evaluation in Therapeutics Institut National de la Santé et de la Recherche Médicale Epidemiology in Dermatology and Evaluation in Therapeutics Institut Mondor de Recherche Biomédicale Centre National de Recherche en Génomique Humaine Institut Mondor de Recherche Biomédicale Institut Mondor de Recherche Biomédicale Assistance publique - Hôpitaux de Paris (AP-HP) Institut Mondor de Recherche Biomédicale Assistance publique - Hôpitaux de Paris (AP-HP)

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Résumé : Hidradenitis suppurativa (HS) is a severe skin disorder affecting 1% of the global population, with a complex and poorly understood pathogenesis involving aberrant keratinization and autoinflammation. It remains unclear whether autoinflammatory events precede or follow hyperkeratotic changes in hair follicle (HF) epithelia. Using single-cell RNA sequencing, we characterized HF cell populations in HS patients and investigated their role in disease pathogenesis. We uncovered two distinct differentiation trajectories of HF stem cells (HF-SCs): one leading to interfollicular epidermis (IFE) basal cells enriched in inflammatory pathways, and another giving rise to outer root sheath (ORS) cells associated with keratinization. In HS lesions, both populations displayed altered inflammatory phenotypes and were closely linked to immune cell infiltration, pointing to a role in disease heterogeneity. By integrating clinical features with HF cell composition from 49 HS patients, we identified three major endotypes: (i) an inflammatory subtype, marked by T cell infiltration and an expansion of IFE basal cells; (ii) a keratinizing subtype, characterized by ORS enrichment and minimal inflammation; and a mixed subtype, exhibiting features of follicular remodeling, fistula formation, and variable immune involvement. These findings provide novel insights into the epithelial-immune interactions that drive HS and support a stratified therapeutic approach tailored to the specific HF dysfunctions of each patient subgroup.

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Fichiers liés : Onfroy_Hue_HidraSupp_2025.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 27/06/2025
• Auteurs : Céline BoehmAlberto Krone-MartinsAntónio AmorimGuillem Anglada-EscudéAlexis BrandekerFrederic CourbinTorsten EnßlinAntónio FalcãoKatherine FreeseBerry HollLucas LabadieAlain LegerFabien MalbetGary MamonBarbara McarthurAlcione MoraMichael ShaoAlessandro SozzettiDouglas SpolyarEva VillaverConrado AlbertusStefano BertoneHervé BouyMichael Boylan-KolchinAnthony BrownWarren BrownVitor CardosoL. CheminRiccardo ClaudiAlexandre C.M. CorreiaMariateresa CrostaAntoine CrouzierFrancis-Yan Cyr-RacineMario DamassoAntónio da SilvaMelvyn DaviesPayel DasPratika DayalMiguel de Val-BorroAntonaldo DiaferioAdrienne ErickcekMalcolm FairbairnMorgane FortinMalcolm FridlundPaulo GarciaOleg GnedinAriel GoobarPaulo GordoRenaud GoullioudNigel HamblyNathan HaraDavid HobbsErik HogRodrigo A IbataCarme JordiSergei KlionerSergei KopeikinThomas LacroixJacques LaskarChristophe Le Poncin-LafitteXavier LuriSubhabrata MajumdarRichard MasseyRichard MasseyBertrand MennessonDaniel MichalikAndré Moitinho de AlmeidaLeonidas MoustakasLeonidas MoustakasNeil MurrayMatthew MuterspaughMicaela OertelLuisa OstoreroAngeles Perez-GarciaImants PlataisJord I Portell de MoraAndreas QuirrenbachLisa RandallJustin ReadEniko RegosBarnes RoryKrzysztof RybickiPat ScottJean SchneiderJakub ScholtzArnaud SiebertIsmael TerenoJohn TomsickWesley TraubMonica ValluriNicholas WaltonNicholas WaltonLaura WatkinsGlenn WhiteDafydd Wyn EvansLukasz WyrzykowskiRosemary WyseUmmi AbbasJean-Michel AlimiMartin AltmannJoão AlvesRichard AndersonFrédéric ArenouCoryn Bailer-JonesBaugh CarltonMichael BiermannSergi Blanco-CuaresmaAldo Stefano BonomoAvery BroderickGiorgia BussoJuan CabreraJosep Manel CarrascoCarla Sofia CarvalhoMarco CastellaniMarina Cermeño-GavilánPaula ChadwickJeremy DarlingMichael DavidsonFrancesca de AngeliReinaldo de CarvalhoSilvano DesideraChris DoneChristine DucourantDenis ErkalLaurent EyerBenoit FameySofia FeltzingEmilio Fraile GarciaFacundo Ariel GomezCarlos FrenkLaurent GalluccioPhillip GalliLaurent GalluccioPanagiotis GavrasPaolo GiacobbeAriel GoobarRaffaele GrattonFabrizia GuglielmettiEike GuntherDavid HallDiana HarrisonArtie HatzesDaniel HestrofferEmille IshidaPascale JablonkaChristopher JacobsMathilde JauzacJens JascheMathilde JauzacHugh JonesJean-Paul KneibFrancesc JulbeJean-Paul KneibGeorges KordopatisArianne LanconMario Gilberto LattanziJean-Michel LeguidouMatt LehnertHarry LehtoIlidio LopesNicolas F. MartinMarcella MarconiNicolas MartinMaury Marie-ElisabethAnupam MazumdarTatiana MichtchenkoStefano MinardiCarlos MunozGiuseppe MuranteIsabella PaganoOrtwin GerhardIsabella PaganoPaolo PaniGiampaolo PiottoPfenniger DanielGiampaolo PiottoOlivier PreisNicolas ProduitSean N. RaymondHeike RauerSean RaymondRosa ReinaldoYves RevazRibeiro RitaLorenzo RimoldiniArnau Rios HuguetVincenzo RipepiPier-Francesco RocciMaria D. Rodriguez FriasReinaldo R. RosaJohannes SahlmannIppocratis SaltasJosé Pizarro Sand E E LemosLuis M. SarroBjörn Malte SchäferJascha SchewtschenkoDamien SégransanFranck SelsisJoe SilkManuel SilvaFilomena SolitroAlessandro SpagnaVolker SpringelMaria SüvegesRamachrisna TeixeiraTetsuo ShindouPhilippe ThebaultFeng TianCatherine TuronJosé W.F. ValleEugene VasilievJuan VladiloVollmann MartinMartin WardJochen WellerMark WilkinsonSebastian WolfFu XiaotingYoshiyuki YamadaSven ZschockeShay Zucker
• Organismes : Institut d'astrophysique spatiale Université Grenoble Alpes Institut d'Astrophysique de Paris Observatoire de Paris - Site de Paris Institut de Mécanique Céleste et de Calcul des Ephémérides Université de Strasbourg Institut d'Astrophysique de Paris Institut de Mécanique Céleste et de Calcul des Ephémérides Observatoire de Paris - Site de Meudon Laboratoire Univers et Théories Observatoire de Paris - Site de Meudon Observatoire astronomique de Strasbourg Observatoire de Paris - Site de Meudon Galaxies, Etoiles, Physique, Instrumentation Laboratoire d'Astrophysique de Bordeaux [Pessac] Université de Strasbourg Observatoire de la Côte d'Azur Institut de Mécanique Céleste et de Calcul des Ephémérides Université Blaise Pascal - Clermont-Ferrand 2 Université de Strasbourg Centre National d’Études Spatiales [Paris] Institut d'Astrophysique de Paris Université de Strasbourg Joseph Louis LAGRANGE Laboratoire d'Astrophysique de Bordeaux [Pessac] Joseph Louis LAGRANGE Laboratoire d'Astrophysique de Bordeaux [Pessac] Institut d'Astrophysique de Paris Observatoire de Paris - Site de Paris Galaxies, Etoiles, Physique, Instrumentation

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Résumé : In the context of the ESA M5 (medium mission) call we proposed a new satellite mission, Theia, based on relative astrometry and extreme precision to study the motion of very faint objects in the Universe. Theia is primarily designed to study the local dark matter properties, the existence of Earth-like exoplanets in our nearest star systems and the physics of compact objects. Furthermore, about 15 $\%$ of the mission time was dedicated to an open observatory for the wider community to propose complementary science cases. With its unique metrology system and "point and stare" strategy, Theia's precision would have reached the sub micro-arcsecond level. This is about 1000 times better than ESA/Gaia's accuracy for the brightest objects and represents a factor 10-30 improvement for the faintest stars (depending on the exact observational program). In the version submitted to ESA, we proposed an optical (350-1000nm) on-axis TMA telescope. Due to ESA Technology readiness level, the camera's focal plane would have been made of CCD detectors but we anticipated an upgrade with CMOS detectors. Photometric measurements would have been performed during slew time and stabilisation phases needed for reaching the required astrometric precision.

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Fichiers liés : 1707.01348v1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 27/06/2025
• Auteurs : Mathilde BoussacF. FaggianelliEstelle HarrochAlexandre EusebioMargherita FabbriFabienne Ory MagneEmeline DescampsOlivier J. RascolChloé LaurencinAna MarquesMathieu AnheimBruno GiordanaLucie HopesCaroline MoreauAnne Sophie RollandDavid DevosDavid MaltêteSolène AnsquerElodie HainqueSophie DrapierJean-Philippe BrandelTiphaine RouaudDominique GuehlBéchir JarrayaFazia Mélissa TirTatiana WitjasJean-Philippe AzulayChristine Brefel-Courbon
• Organismes : Toulouse NeuroImaging Center Hôpital de la Timone [CHU - APHM] Centre d'investigation clinique de Toulouse Centre Hospitalier Universitaire de Toulouse Institut de Neurosciences de la Timone Hôpital de la Timone [CHU - APHM] Toulouse NeuroImaging Center Département Neurologie [CHU Toulouse] Centre d'investigation clinique de Toulouse Toulouse NeuroImaging Center Centre National de la Recherche Scientifique Toulouse NeuroImaging Center Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Pathophysiologie de la maladie de Parkinson et des troubles associés CHU Clermont-Ferrand Institut Pascal Thérapie guidée par l'image Service de Neurologie [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Institut de Génétique et de Biologie Moléculaire et Cellulaire Hôpital Pasteur [Nice] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire [Rennes] Institut de recherche en santé, environnement et travail Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Université de Lille Département de Pharmacologie Médicale [Lille] Département de neurologie [Lille] CHU Rouen CIC Poitiers – Centre d'investigation clinique de Poitiers CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] AP-HP. Sorbonne Université Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Bordeaux Institut des Maladies Neurodégénératives [Bordeaux] Institut National de la Santé et de la Recherche Médicale Université Paris-Saclay Commissariat à l'énergie atomique et aux énergies alternatives Université de Versailles Saint-Quentin-en-Yvelines Hôpital Foch [Suresnes] CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Institut de Neurosciences de la Timone Institut de Neurosciences de la Timone Toulouse NeuroImaging Center Centre d’Excellence en Maladies Neurodégénératives
• Publié dans Journal of Parkinson's disease le 29/10/2020

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Résumé : Background: Parkinson's disease (PD) patients on dopaminergic drugs may experience non-motor fluctuations (NMFs) which are often heterogeneous and respond variably to treatments. Objective: We evaluated if personality was associated to NMFs and could modulate the NMFs responsiveness to dopaminergic medication and deep brain stimulation of the sub-thalamic nucleus (STN-DBS). Methods: From the PREDISTIM cohort, personality dimensions of 235 PD patients were assessed by the Temperament and Character Inventory (TCI) before STN-DBS (V0). NMFs were evaluated using the NMFs Severity Scale at V0 and one year after STN-DBS (V1). Linear regression models were performed between TCI dimensions and NMFs at V0; and logistic regression models were done between TCI dimensions and 1) groups of dopa-sensitive patients (responders to ON medication at V0) versus non-dopa-sensitive ones, and 2) responders versus non-responders to STN-DBS at V1. Odds ratios (OR) were also calculated. Results: Significant associations were found between two TCI personality dimensions (“Harm Avoidance” and “Self-Directedness”) and severity of NMFs in OFF medication at V0: PD patients with higher Harm Avoidance and lower Self-Directedness scores having more NMFs. TCI personality dimensions were not associated with the dopa-sensitivity while Novelty Seeking was significantly associated with the STN-DBS-responder group for the psychiatric (OR = 1.09 [1.02–1.17]) and for the dysautonomic NMFs (OR = 1.11 [1.04–1.18]). Conclusions: Certain personality dimensions (Harm Avoidance and Self-Directedness) are associated with NMFs severity at baseline, and PD patients with high Novelty Seeking seem to be better candidates for NMFs improvement after STN-DBS. Plain Language Summary Non-motor fluctuations are highly invalidating for patients with Parkinson's disease and their response to treatments is variable. This new research examined personality dimensions impact on non-motor fluctuations and their responsiveness to dopaminergic medication and to deep brain stimulation. Two hundred and thirty-five patients with Parkinson's disease participated in the study and filled out several questionnaires to score their personality dimensions and their non-motor fluctuations severity before and after one year of deep brain stimulation. Comparisons were done between different groups of patients according to their response to dopaminergic treatments and to deep brain stimulation. As results, patients with personality traits of high “Harm Avoidance” (more anxious individuals) and low “Self-Directedness” (less goal-oriented individuals) had globally more non-motor fluctuations, and the personality dimension of “Novelty Seeking” (impulsive individuals) was related to a better non-motor fluctuations responsiveness to deep brain stimulation. Hence, non-motor fluctuations are associated with some specific personality dimensions on top of early onset of Parkinson's disease, long disease-duration, high doses of levodopa and female gender. Moreover, Parkinson's disease patients with impulsive-like personality seem to be better candidates for non-motor fluctuations improvement after deep brain stimulation.

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• Type de publi. : Article dans une revue
• Date de publi. : 26/06/2025
• Auteurs : Delphine DouilletAlexandre GodonGeoffroy RousseauStéphanie RuizFanny VardonEmmanuel de MaistreDelphine GarrigueIsabelle GouinYves GruelJulien LanoiseléeFrédéric LapostolleDominique LasneAlexandre MansourAnne-Céline MartinMikaël MazighiPatrick MismettiThomas MoumnehFarès MoustafaAndrea PenalozaStéphanie RoulletPierre-Marie RoyVirginie SiguretJeannot SchmidtCharles TacquardKarim TazarourtePaul ZuffereyPhilippe NguyenAnne Godier
• Organismes : MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Régional Universitaire de Tours Pôle Anesthésie Réanimation [CHU de Toulouse] Centre Hospitalier Universitaire de Toulouse Université de Toulouse CHU Dijon Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire [Rennes] Institut de recherche en santé, environnement et travail Membrane Signalling and Inflammation in reperfusion Injuries Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Santé Ingénierie Biologie Saint-Etienne Assistance publique - Hôpitaux de Paris (AP-HP) Hôpital Avicenne [AP-HP] Marqueurs cardiovasculaires en situation de stress Assistance publique - Hôpitaux de Paris (AP-HP) Hémostase, Inflammation, Thrombose Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire [Rennes] Institut de recherche en santé, environnement et travail Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis Hôpital Européen Georges Pompidou [APHP] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Service de neurologie [Univ. Paris VII] Optimisation thérapeutique en Neuropsychopharmacologie Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Éducation Éthique Santé EA 7505 Centre Hospitalier Régional Universitaire de Tours CHU Clermont-Ferrand Unité de Nutrition Humaine Cliniques Universitaires Saint-Luc [Bruxelles] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Hémostase, Inflammation, Thrombose Centre Hépato-Biliaire [Hôpital Paul Brousse] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Universitaire d'Angers MitoVasc - Équipe CarME (Cardiovascular Pathophysiology) Hôpital Lariboisière-Fernand-Widal [APHP] Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis Laboratoire de Psychologie Sociale et Cognitive Etablissement Français du Sang - Grand Est Centre Hospitalier Universitaire [Strasbourg] Research on Healthcare Performance Hospices Civils de Lyon Santé Ingénierie Biologie Saint-Etienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital universitaire Robert Debré [Reims] Pharmacologie et Pathologies Fragilisantes Université Paris Cité Hôpital Européen Georges Pompidou [APHP]
• Publié dans Anaesthesia Critical Care & Pain Medicine le 27/10/2020

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 25/06/2025
• Auteurs : Jill-Léa RamassamyPatricia TortevoyeBalthazar NtabGabriel CarlesJean-Pierre DrozPierre CouppiéGiovanni BegliominiJean-François CarodN’detodji-Bill WankpoKarim AbdelmoumenPhilippe V AfonsoOlivier CassarAntoine TalarminOlivier HermineLoïc EpelboinAmbroise MarçaisAntoine Gessain
• Organismes : Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Université Claude Bernard Lyon 1 Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Centre Hospitalier de l'Ouest Guyanais Franck Joly [Saint-Laurent-du-Maroni, Guyane Française] Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Université de La Réunion Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology Transmission, Réservoir et Diversité des Pathogènes - Transmission, Reservoir and Diversity of Pathogens [Institut Pasteur Guadeloupe, France] Institut Necker Enfants-Malades Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Université de Guyane Centre d'Investigation Clinique Antilles-Guyane Institut Necker Enfants-Malades Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology

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Résumé : Adult T-cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). French Guiana, located in northeastern South America, is a region of high HTLV-1 endemicity with a multiethnic population. We conducted a comprehensive 30-year study of ATL cases diagnosed between 1990 and 2019, capturing nearly all confirmed ATL cases in the territory (n=137). The predominant subtypes were lymphoma (58%) and acute ATL (36%). Striking ethnic disparities emerged: 69% of patients were Maroons, and the median age at diagnosis was 43 years among Maroons versus 58 years among Creoles. Survival outcomes were uniformly poor, with median overall survival of 2.7 months for acute and 5.2 months for lymphoma ATL. In multivariate analysis, acute ATL subtype and hepatosplenomegaly at diagnosis were independently associated with worse survival. Complete HTLV-1 genome sequences were obtained for seven ATL cases and phylogenetic analysis of complete genomes revealed strong ethnic clustering: all Creole strains belonged to the Transcontinental subtype, while all Maroon strains belonged to the West African subtype. Moreover, HTLV-1 prevalence in the general population was measured among 1,078 Creoles tested in 1998, with a prevalence of 3.1%, markedly lower and occurring at older ages compared to previously published data for the Maroon population. Our findings highlight pronounced disparities in ATL epidemiology by ethnic group, and emphasize the need for targeted prevention, early diagnosis, and improved care in high-risk populations.

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Fichiers liés : afonso.pdf

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• Type de publi. : Rapport
• Date de publi. : 25/06/2025
• Auteurs : Rodolphe LeméeJean-François HumbertÉric AbadieZouher AmzilElisa BerdaletRonel BiréMarie-Yasmine Dechraoui BotteinLuc de HaroNicolas DelcourtValérie FessardJean‐philippe JaegCésar MatteiAnne OppligerAnne‐sophie PavauxEva TernonGilles BornertAnne TogolaJean BaronJean Luc BoudenneNicolas CimetiereBruno CoulombChristophe DagotSabine DenoozIsabelle DublineauFrédéric FederMatthieu FournierStéphane Garnaud-CorbelNathalie GarrecJohnny GasperiJulio GonçalvèsJean-Louis GonzalezOlivier HornerMichel JoyeuxJérôme LabanowskiSophie Lardy-FontanFrançoise LucasChristophe MechoukLaurent MoulinDamien MoulyFabienne PetitCatherine QuiblierPauline Rousseau-GueutinMarie-Pierre Sauvant-RochatMichèle TremblayBruno Le BizecMarie-Louise ScippoPierre-Marie BadotRachida ChekriChristine DemeilliersVirginie DesvignesErwan EngelGautier EppeAnne‐sophie FicheuxEric HoudeauEmilie LanceOlivier LaprévoteMichel LaurentieLudovic Le HégaratJean-Charles LeblancNicolas LoiseauDavid MakowskiFrancesca Romana ManciniEric MarchioniJean‐françois MasfaraudMathilde MunierIsabelle P. OswaldAnne PlatelYann SivryPaule VasseurEstelle Checlair-WesterbergNathalie ArnichEléonore NeyCarole CatastiniNicolas Loiseau
• Organismes : Laboratoire d'océanographie de Villefranche Institut d'écologie et des sciences de l'environnement de Paris Délégation Océan Indien Unité Physiologie et Toxines des Microalgues Toxiques et Nuisibles Institut national des sciences et techniques de la mer Laboratoire de sécurité des aliments, sites de Maisons-Alfort et de Boulogne-sur-Mer Ecology and Conservation Science for Sustainable Seas Hôpital Sainte-Marguerite [CHU - APHM] Centre antipoison et de toxicovigilance [CHU Toulouse] Laboratoire de Fougères - ANSES Ecole Nationale Vétérinaire de Toulouse MitoVasc - Équipe CarME (Cardiovascular Pathophysiology) Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Laboratoire de Génie des Procédés et Matériaux Laboratoire d'océanographie de Villefranche Service de Santé des Armées Bureau de Recherches Géologiques et Minières Eau de Paris Laboratoire Chimie de l'environnement Institut des Sciences Chimiques de Rennes Laboratoire Chimie de l'environnement Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Société wallonne des eaux Unité d'expertise des sites et des déchets radioactifs Centre de Coopération Internationale en Recherche Agronomique pour le Développement Morphodynamique Continentale et Côtière Université de Rouen Normandie Service anthropisation et fonctionnement des écosystèmes terrestres Centre Scientifique et Technique du Bâtiment Eau et Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Institut Français de Recherche pour l'Exploitation de la Mer Laboratoire National d’Hydraulique et Environnement École Pratique des Hautes Études Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] Laboratoire d'hydrologie de Nancy Laboratoire Eau Environnement et Systèmes Urbains Ville de Lausanne Eau de Paris Santé Publique France, Occitanie [Toulouse, France] Morphodynamique Continentale et Côtière Muséum national d'Histoire naturelle École des Hautes Études en Santé Publique [EHESP] Université de Rennes Département des sciences en santé environnementale Institut Pascal Retraité Laboratoire d'étude des Résidus et Contaminants dans les Aliments Fundamental and Applied Research for Animals & Health Laboratoire Chrono-environnement (UMR 6249) Éléments Traces Métalliques et Minéraux Environnement et Prévention en Santé des Populations Centre Scientifique et Technique du Bâtiment Qualité des Produits Animaux Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Laboratoire sur les interactions Epithéliums Neurones ToxAlim Stress Environnementaux et BIOsurveillance des milieux aquatiques Cibles Thérapeutiques et conception de médicaments Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail ToxAlim Mathématiques et Informatique Appliquées Centre de recherche en épidémiologie et santé des populations Institut Pluridisciplinaire Hubert Curien Laboratoire Interdisciplinaire des Environnements Continentaux MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire d'Angers Biosynthèse & Toxicité des Mycotoxines Laboratoire de toxicologie génétique [Lille] Laboratoire de géochimie des Eaux Laboratoire Interdisciplinaire des Environnements Continentaux Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Toxicologie Intégrative & Métabolisme

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Résumé : In France, the presence of marine microalgae of the genus Ostreopsis has been identified repeatedly on the Mediterranean coast for several years, whereas on the French Basque coasts its presence is much more recent. In the summers of 2021 and 2022, major Ostreopsis flowering episodes were reported on the Basque coast, resulting in several hundred cases of intoxication among holidaymakers and residents. The main route of human exposure is inhalation of aerosols, although it is not yet known whether the agents responsible for poisoning are Ostreopsis cells, cell debris, known toxins produced by Ostreopsis, or other as yet unidentified compounds. Other routes of exposure (dermal contact, eye contact, ingestion of contaminated water or seafood) are also possible. Poisoning is manifested through various signs and symptoms, occurring within 48 hours of exposure (Neurosensory and neurological, respiratory, dermal and digestive). This document presents the opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES), established from the work of its WATER and ERCA Expert Committees. ANSES received a request from the Directorate General for Health (DGS) and the Directorate General for Food (DGAL) to update knowledge about Ostreopsis that had been reported in the Agency's opinions from 2007 and 2008 (ANSES, 2007 and 2008), and draw up specific recommendations for managing Ostreopsis proliferation on the Basque coast. The literature review conducted as part of this expert appraisal revealed that knowledge about the genus Ostreopsis (diversity, biology, ecology, toxins produced) is still too fragmentary to characterise the hazard and risk to human health. Nevertheless to help local authorities affected by Ostreopsis blooms, Agency proposes a surveillance and quality monitoring strategy based on collaboration between site managers and the regional health agencies (ARSs), applicable to sites currently subject to bathing water quality monitoring and water sports sites that meet the conditions below.

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Fichiers liés : Food Risk Assess Europe - 2025 - Lemée - Opinion of the French Agency for Food Environmental and Occupational Health .pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 25/06/2025
• Auteurs : Natalie ZwingLena Voith von VoithenbergLaurent AlbertiSascha Michael GabrielJosep Monné RodriguezRomi FeddersenJean-Philippe FoyFrancesca DamiolaNicolas GadotPierre SaintignyBruno Gomes
• Organismes : Plateforme anatomopathologie recherche Lyon-Est Université Claude Bernard Lyon 1 Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Dynamiques du Cancer, adaptation et modélisation
• Publié dans Journal for Immunotherapy of Cancer le 24/10/2020

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Résumé : Background Head and neck squamous cell carcinoma (HNSCC) exhibits low response rates to immunotherapies, with only about 15–25% of patients responding to monotherapy and 30–45% to combination therapy. This limited effectiveness is attributed to significant intertumor and intratumor heterogeneity, which affects the immunological activity of individual tumors and their regions, thereby influencing immunotherapy outcomes. Various biomarkers at the gene and protein expression levels have been identified to predict the response to immunotherapy in HNSCC. Methods In this study, we evaluated intertumor heterogeneity using a 27-gene expression signature to stratify tumors by their immunologic activity status. We investigated intertumor heterogeneity at the molecular and cellular level and further analyzed intratumor spatial heterogeneity within and across these subgroups by using spatial multiomics approaches. Results Immunologically active tumors showed increased interferon-γ and interferon-α signaling and upregulation of major histocompatibility complex-I signaling and genes involved in antigen presentation. Chemokines such as CXCL8 and CXCL9 , which are crucial for immune cell recruitment, were differentially regulated. The spatial analysis revealed that active tumors tended to show higher autocorrelation of homogeneous regions with immune cell infiltration compared with inactive tumors. Proximity measures showed an increased colocalization of immune cells, particularly CD8+ T cells, T helper cells, and regulatory T cells, near tumor cells in active tumors. Despite this high immune infiltration, HNSCC often has an immunosuppressive microenvironment, which we observed as a colocalization of programmed cell death protein-1+ (PD-1+) cytotoxic T cells and cytotoxic T cells, indicating regional differences in active and exhausted cell ratios. Furthermore, upregulation of JAK-STAT3 signaling in active tumors was potentially associated with immune evasion. Conclusions The spatial analysis at multiple omics levels allowed for a detailed investigation of molecular and cell type markers to further distinguish between immunologically active and immunosuppressive microenvironments and their spatial heterogeneity. Our study demonstrates that, besides gene expression signatures, cell colocalization signatures can infer immunological activity in HNSCC, thus predicting immunotherapy response.

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• Type de publi. : Article dans une revue
• Date de publi. : 25/06/2025
• Auteurs : Alain LécureuilMassimiliano CorsoStéphanie BoutetSophie Le GallRegina NiñolesJose GadeaPhilippe GuercheSophie Jasinski
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Unité de recherche sur les Biopolymères, Interactions Assemblages BIBS - Plateforme Bioressources : Imagerie, Biochimie & Structure Instituto de Biologia Molecular y Celular de Plantas Instituto de Biologia Molecular y Celular de Plantas Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal
• Publié dans The Plant Journal le 26/10/2020

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Résumé : SUMMARY Brassicaceae species mainly accumulate oil and protein in their seeds, which are essential to human life as a source of food, but also as animal feed and resources for green chemistry. To date, Brassicaceae crops such as rapeseed have been selected mainly for their oil content. However, there is a growing interest in their seed protein content. A strong negative correlation between oil and protein content makes it difficult to increase both compounds simultaneously. In this study, an Arabidopsis thaliana homozygous EMS mutant library was screened for seed oil and protein content by near‐infrared spectroscopy with the aim of identifying mutants with impaired oil/protein correlation. The mutant most affected in this correlation was found to be in the TRANSPARENT TESTA7 gene, which is involved in the flavonoid biosynthetic pathway. Analysis of different mutants in the flavonoid pathway revealed that the tt7 mutants were the only ones to show such a significant reduction in seed oil content, highlighting a phenotype never described before for the tt7 mutants and suggesting a specific role for TT7 in the interplay between the oil and flavonoid biosynthetic pathways. Untargeted metabolomic analysis allowed the identification of metabolic features that are highly accumulated and specific to tt7 seeds compared to the other genotypes and genetic analysis established that the accumulation of kaempferol‐3‐O‐rhamnoside seems to be responsible for the seed oil reduction in tt7 mutants.

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Fichiers liés : 2025_Lécureuil_The Plant Journal.pdf

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