Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Nathalie JustPierre Marie ChevillardMartine BataillerJean-Philippe DuboisPascal VaudinDelphine PillonMartine Migaud
• Organismes : Physiologie de la reproduction et des comportements [Nouzilly] Danish Research Centre for Magnetic Resonance Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly]
• Publié dans Neuroscience le 24/10/2020

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Résumé : Most organisms on earth, humans included, have developed strategies to cope with environmental day-night and seasonal cycles to survive. For most of them, their physiological and behavioral functions, including the reproductive function, are synchronized with the annual changes of day length, to ensure winter survival and subsequent reproductive success in the following spring. Sheep are sensitive to photoperiod, which also regulates natural adult neurogenesis in their hypothalamus. We postulate that the ovine model represents a good alternative to study the functional and metabolic changes occurring in response to photoperiodic changes in hypothalamic structures of the brain. Here, the impact of the photoperiod on the neurovascular coupling and the metabolism of the hypothalamic structures was investigated at 3T using BOLD fMRI, perfusion-MRI and pro-ton magnetic resonance spectroscopy (1H-MRS). A longitudinal study involving 8 ewes was conducted during long days (LD) and short days (SD) revealing significant BOLD, rCBV and metabolic changes in hypothalamic structures of the ewe brain between LD and SD. More specifically, the transition between LD and SD revealed neg-ative BOLD responses to hypercapnia at the beginning of SD period followed by significant increases in BOLD, rCBV, Glx and tNAA concentrations towards the end of the SD period. These observations suggest longitudinal mechanisms promoting the proliferation and differentiation of neural stem cells within the hypothalamic niche of breeding ewes. We conclude that multiparametric MRI studies including 1H-MRS could be promising non-invasive translational techniques to investigate the existence of natural adult neurogenesis in-vivo in gyrencephalic brains.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Thierno Mamadou MillimonoAlioune CamaraGustave MabiamaMamady DafféFarid BoumedienePierre-Marie PreuxJean-Claude DesportPhilippe FayemendyPierre Jésus
• Organismes : Epidémiologie des Maladies Chroniques en zone tropicale Université Gamal Abdel Nasser de Conakry Université Gamal Abdel Nasser de Conakry Université de Douala Université Gamal Abdel Nasser de Conakry Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Abstract Aging of the Guinean population is a public health concern for the coming years, and the nutritional status of older people is virtually unknown. We also know that this population is growing and that undernutrition and obesity can affect the health of older adults. This study aimed to assess the nutritional status of older people in the general population of Guinea and its associated factors. A representative cross-sectional survey was conducted using sociodemographic, clinical, and anthropometric data (weight and height). Oral status was assessed by using the University of Nebraska Oral Status Scale. Visual acuity was assessed using the Monoyer scale. The standardized prevalence ratio (SPR) of the nutritional status was calculated for each region. The sample included 1698 subjects with a mean BMI of 22.6 ± 4.3 kg/m 2 . A total of 50.3% had impaired oral status and 20.3% had moderately to severely impaired visual acuity. The prevalence of undernutrition was 14.4% and of obesity 5.7%. Differences in the prevalence of nutritional status were found between regions, with an SPR > 1 for undernutrition in the Labé region (SPR 1.9, 95% CI = 1.5–2.5) and for obesity in the Conakry and Kindia regions (SPR of 2.90, 95% CI = 2.0–4.05 and 2.32, 95% CI = 1.5–3.3, respectively). In Guinea, The prevalence of nutritional disorders was approximately 20%. Screening and management of the health and nutritional status of older adults should be a national priority, and management should be adapted to each region of the country.

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Fichiers liés : s41598-023-42494-3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Grégoire MarretStéphane TemamMaud KamalCaroline EvenJean-Pierre DelordCaroline HoffmannGilles DolivetOlivier MalardJérôme FayetteOlivier CapitainS. VergezLionel GeoffroisFrédéric RollandPhilippe ZrounbaLaurent LaccourreyeEsma Saada-BouzidNicolas AideValérie BénaventJerzy KlijianenkoConstance LamyElodie GirardSophie VacherJulien Masliah-PlanchonLeanne de KoningVincent PuardEdith BorcomanMarta JimenezIvan BiècheJocelyn GalChristophe Le Tourneau
• Organismes : Institut Curie [Paris] Département de radiothérapie [Gustave Roussy] Cancer Campus Département de cancérologie cervico-faciale [Gustave Roussy] Département de médecine oncologique [Gustave Roussy] Institut Curie [Paris] Département de radiothérapie [Gustave Roussy] Cancer Campus Département de cancérologie cervico-faciale [Gustave Roussy] Département de médecine oncologique [Gustave Roussy] Institut Universitaire du Cancer de Toulouse - Oncopole Oncopole Claudius Regaud Immunité et cancer Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Centre de Recherche en Automatique de Nancy Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut Universitaire du Cancer de Toulouse - Oncopole Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] CRLCC René Gauducheau Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Cytokines : structure, signalisation et prolifération tumorale Institut de Recherche sur le Cancer et le Vieillissement Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Laboratoire International Associé Réponse des Organismes et Populations face au Stress Environnemental - Université Côte d’Azur - Centre Scientifique de Monaco Centre Scientifique de Monaco Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers UNICANCER Immunité et cancer Institut Curie [Paris] Département de radiothérapie [Gustave Roussy] Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] UNICANCER Institut Curie [Paris] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe
• Publié dans Scientific Reports le 26/10/2020

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Résumé : There is no strong and reliable predictive biomarker in head and neck squamous cell carcinoma (HNSCC) for EGFR inhibitors. We aimed to identify predictive and pharmacodynamic biomarkers of efficacy of afatinib, a pan-HER tyrosine kinase inhibitor, in a window-of-opportunity trial (NCT01415674). Multi-omics analyses were carried out on pre-treatment biopsy and surgical specimen for biological assessment of afatinib activity. Sixty-one treatment-naïve and operable HNSCC patients were randomised to afatinib 40 mg/day for 21–28 days versus no treatment. Afatinib produced a high rate of metabolic response. Responders had a higher expression of pERK1/2 ( P = 0.02) and lower expressions of pHER4 ( P = 0.03) and pRB1 ( P = 0.002) in pre-treatment biopsy compared to non-responders. At the cellular level, responders displayed an enrichment of tumor-infiltrating B cells under afatinib ( P = 0.02). At the molecular level, NF-kappa B signaling was over-represented among upregulated genes in non-responders ( P < 0.001; FDR = 0.01). Although exploratory, phosphoproteomics-based biomarkers deserve further investigations as predictors of afatinib efficacy.

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Fichiers liés : Randomized phase II study of preoperative afatinib in untreated head and neck cancers predictive and pharmacodynamic biomarkers of activity.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Jean-François David CadranelIsabelle Ollivier-HourmandJacques CadranelThierry ThevenotHonoré ZougmoreEric Nguyen-KhacChristophe BureauManon AllaireJean-Baptiste NousbaumVéronique Loustaud-RattiXavier CaussePhilippe SogniBertrand HanslikMarc BourliereJean-Marie PeronNathalie Ganne-CarrieThong DaoDominique ThabutBernard. MaitreNabil DebziRyad SmadhiRoger SombieRaimi KpossouOlivier NouelJulien BissonnetteIsaac RuizMourad MedmounSergio Negrin DastisPierre DeltenreFlorent ArtruChantal RaherisonLaure ElkriefTristan Lemagoarou
• Organismes : CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Service d'Hépatologie [CHRU Besançon] CHU Amiens-Picardie Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV Centre Hospitalier Universitaire de Toulouse Centre de recherche sur l'Inflammation CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire de Brest Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation Institut Cochin Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Hôpital Saint-Joseph [Marseille] Centre Hospitalier Universitaire de Toulouse Hôpital Avicenne [AP-HP] Centre de Recherche des Cordeliers CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Pitié-Salpêtrière [AP-HP] Centre de recherche en épidémiologie et santé des populations Service Addictologie [CHU Nîmes] Sorbonne Université Centre Hospitalo-Universitaire Mustapha Bacha
• Publié dans BMC Gastroenterology le 01/11/2020

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Résumé : Background The Hepatic hydrothorax is a pleural effusion related to portal hypertension; its diagnosis and therapeutic management may be difficult. The aims of this article are which follows: To gather the practices of hepatogastroenterologists or pulmonologists practitioners regarding the diagnosis and management of the hepatic hydrothorax. Methods Practitioners from 13 French- speaking countries were invited to answer an online questionnaire on the hepatic hydrothorax diagnosis and its management. Results Five hundred twenty-eight practitioners (80% from France) responded to this survey. 75% were hepatogastroenterologists, 20% pulmonologists and the remaining 5% belonged to other specialities. The Hepatic hydrothorax can be located on the left lung for 64% of the responders (66% hepatogastroenterologists vs 57% pulmonologists; p = 0.25); The Hepatic hydrothorax can exist in the absence of clinical ascites for 91% of the responders (93% hepatogastroenterologists vs 88% pulmonologists; p = 0.27). An Ultrasound pleural scanning was systematically performed before a puncture for 43% of the responders (36% hepatogastroenterologists vs 70% pulmonologists; p < 0.001). A chest X-ray was performed before a puncture for 73% of the respondeurs (79% hepatogastroenterologists vs 54% pulmonologists; p < 0.001). In case of a spontaneous bacterial empyema, an albumin infusion was used by 73% hepatogastroenterologists and 20% pulmonologists ( p < 0.001). A drain was used by 37% of the responders (37% hepatogastroenterologists vs 31% pulmonologists; p = 0.26).An Indwelling pleural catheter was used by 50% pulmonologists and 22% hepatogastroenterologists ( p < 0.01). TIPS was recommended by 78% of the responders (85% hepatogastroenterologists vs 52% pulmonologists; p < 0.001) and a liver transplantation, by 76% of the responders (86% hepatogastroenterologists vs 44% pulmonologists; p < 0.001). Conclusions The results of this large study provide important data on practices of French speaking hepatogastroenterologists and pulmonologists; it appears that recommendations are warranted.

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Fichiers liés : s12876-023-02931-z.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Edouard CaspersenPierre-Grégoire GuinotBertrand RozecJean-Ferréol OilleauJean-Luc FellahiPhilippe GaudardEmmanuel LorneYazine MahjoubEmmanuel BesnierMouhamed Djahoum MoussaNicolas MongardonJean-Luc HanouzAnaïs BriantLaure Peyro Saint PaulClémence TomadessoJean-Jacques ParientiRichard DescampsAlina DenisenkoMarc-Olivier Fischer
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Trials le 31/10/2020

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Résumé : Abstract Background Postoperative atrial fibrillation (PoAF) after cardiac surgery has a high incidence of 30%, but its management is controversial. Two strategies are recommended without evidence of a superiority of one against the other: rate control with beta-blocker or rhythm control with amiodarone. Landiolol is a new-generation beta-blocker with fast onset and short half-life. One retrospective, single-center study compared landiolol to amiodarone for PoAF after cardiac surgery with a better hemodynamic stability and a higher rate of reduction to sinus rhythm with landiolol, justifying the need for a multicenter randomized controlled trial. Our aim is to compare landiolol to amiodarone in the setting of PoAF after cardiac surgery with the hypothesis of a higher rate of reduction to sinus rhythm with landiolol during the 48 h after the first episode of POAF. Methods The FAAC trial is a multicenter single-blind two parallel-arm randomized study, which planned to include 350 patients with a first episode of PoAF following cardiac surgery. The duration of the study is 2 years. The patients are randomized in two arms: a landiolol group and an amiodarone group. Randomization (Ennov Clinical®) is performed by the anesthesiologist in charge of the patient if PoAF is persistent for at least 30 min after correction of hypovolemia, dyskalemia, and absence of pericardial effusion on a transthoracic echocardiography done at bedside. Our hypothesis is an increase of the percentage of patients in sinus rhythm from 70 to 85% with landiolol in less than 48 h after onset of PoAF (alpha risk = 5%, power = 90%, bilateral test). Discussion The FAAC trial was approved by the Ethics Committee of EST III with approval number 19.05.08. The FAAC trial is the first randomized controlled trial comparing landiolol to amiodarone for PoAF after cardiac surgery. In case of higher rate of reduction with landiolol, this beta-blocker could be the drug of choice used in this context as to reduce the need for anticoagulant therapy and reduce the risk of complications of anticoagulant therapy for patients with a first episode of postoperative atrial fibrillation after cardiac surgery. Trial registration ClinicalTrials.gov NCT04223739. Registered on January 10, 2020.

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Fichiers liés : s13063-023-07353-6.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste MilisavljevicAdrian GervaisPaul BastardTakaki AsanoLucy BizienFederica BarzaghiHassan AbolhassaniAhmad Abou TayounAlessandro AiutiIlad Alavi DarazamLuis AllendeRebeca Alonso-AriasAndrés Augusto AriasGokhan AytekinPeter BergmanSimone BondesanYenan BrycesonIngrid BustosOscar Cabrera-MaranteSheila CarcelPaola CarreraGiorgio CasariKhalil ChaïbiRoger ColobranAntonio Condino-NetoLaura CovillOttavia DelmonteLoubna El ZeinCarlos FloresPeter GregersenMarta GutFilomeen HaerynckRabih HalwaniSelda HancerliLennart HammarströmNevin HatipoğluAdem KarbuzSevgi KelesChristèle KyhengRafael Leon-LopezJose Luis FrancoDavood MansouriJavier Martinez-PicadoOzge Metin AkcanIsabelle MigeottePierre-Emmanuel MorangeGuillaume MorelleAndrea Martin-NaldaGiuseppe NovelliAntonio NovelliTayfun OzcelikFigen PalabiyikQiang Pan-HammarströmRebeca Pérez de DiegoLaura Planas-SerraDaniel PleguezueloCarolina PrandoAurora PujolLuis Felipe ReyesJacques RivièreCarlos Rodriguez-GallegoJulian RojasPatrizia Rovere-QueriniAgatha SchlüterMohammad ShahrooeiAli SobhPere Soler-PalacinYacine Tandjaoui-LambiotteImran TipuCristina TresoldiJesus TroyaDiederik van de BeekMayana ZatzPawel ZawadzkiSaleh Zaid Al-MuhsenMohammed Faraj AlosaimiFahad AlsohimeHagit Baris-FeldmanManish ButteStefan ConstantinescuMegan CooperClifton DalgardJacques FellayJames HeathYu-Lung LauRichard LiftonTom ManiatisTrine MogensenHorst von BernuthAlban LermineMichel VidaudAnne BolandJean-François DeleuzeRobert NussbaumAmanda Kahn-KirbyFrance MentreSarah TubianaGuy GorochovFlorence TubachPierre HausfaterLaurent AbelSaleh Al-MuhsenFahd Al-MullaMark AndersonEvangelos AndreakosAndrés AriasHagit Baris FeldmanAlexandre BelotCatherine BiggsDusan BogunovicAnastasiia BondarenkoAhmed BousfihaPetter BrodinYenan BrycesonCarlos BustamanteSamya ChakravortyJohn ChristodoulouMurkesh DesaiBeth DroletJamila El BaghdadiSara Espinosa-PadillaJosé Luis FrancoAntoine FroidureDavid HaginSarah HenricksonElena HsiehEystein HusebyeKohsuke ImaiYuval ItanErich JarvisTimokratis KaramitrosKai KisandCheng-Lung KuYun LingCarrie LucasLászló MaródiIsabelle MeytsJoshua MilnerKristina MironskaTomohiro MorioLisa NgLuigi NotarangeloCliona O’FarrellySatoshi OkadaAnna PlanasLluis Quintana-MurciLaurent ReniaIgor ResnickCarlos Rodríguez-GallegoVanessa Sancho-ShimizuAnna SedivaMikko SeppänenAnna ShcherbinaOndrej SlabyAndrew SnowPere Soler-PalacínAndrás SpaanIvan TancevskiStuart TangyeSathishkumar RamaswamyStuart TurveyFurkan UddinMohammed UddinDiederik van de BeekDonald VinhMayana ZatzHelen SuJean-Laurent CasanovaSerge BureauYannick VacherAnne Gysembergh-HoualLauren DemervilleAbla ChachouaSébastien AbadRadhiya AbassiAbdelrafie AbdellaouiAbdelkrim AbdelmalekHendy AbdoulHelene AbergelFariza AbeudSophie AbgrallNoemie AbisrorMarylise AdechianNordine AderdourHakeem Farid AdmaneFrederic AdnetSara AfrittHelene AgostiniClaire AguilarSophie AgutTommaso Francesco AielloMarc Ait KaciHafid Ait OufellaGokula AjeenthiravasanVirginie AlauzyFanny Alby-LaurentLucie AllardMarie-Alexandra AlyanakianBlanca Amador BorreroSabrina AmamLucile AmroucheMarc AndronikofDany AnglicheauNadia AnguelDjillali AnnaneMohammed AounzouCaroline AparicioGladys AratusJean-Benoit ArletJeremy ArzoineElisabeth AslangulMona AssefiAdeline AubryLaetitia AudiffredEtienne AudureauChristelle Nathalie AugerJean-Charles AuréganCeline AwotarSonia Ayllon MillaDelphine AzanLaurene AzemarBillal AzzouguenMarwa Bachir ElrufaaiAïda BadsiPrissile BakouboulaColine BalcerowiakFanta BaldeElodie BaldiviaEliane-Flore BangamingoAmandine BaptisteFanny Baran-MarszakCaroline BarauNathalie BargetFlore BaronnetRomain BarthelemyJean-Luc BaudelCamille BaudryElodie BaudryLaurent BeaugerieAdel BelamriNicolas BelaubeRhida BelilitaPierre BellassenRawan BelmokhtarIsabel BeltranRuben BenainousMourad BenallaouaRobert BenamouzigAmélie BenbaraJaouad BenhidaAnis BenkheloufJihene BenlaghaChahinez BenmostafaSkander BenothmaneMiassa BentifraouineLaurence BerardQuentin BernierEnora BertiAstrid BertierLaure BertonSimon BessisAlexandra BeurtonCeline BiancoClara BianquisFrank BidarPhilippe BlancheClarisse BlayauAlexandre BleibtreuEmmanuelle BlinCoralie Bloch-QueyratMarie-Christophe BoissierDiane BollensMarion BolzoniRudy Pierre BompardNicolas BonnetJustine BonnouvrierShirmonecrystal BothaWissam BoucennaFatiha BouchamaOlivier BouchaudHanane BouchghoulTaoueslylia BoudjeblaNoel BoudjemaCatherine BouffardAdrien BougléMeriem BouguerraLeila BourasAgnes BourcierAnne Bourgarit DurandAnne BourrierFabrice BouscaratDiane BouvryNesrine BouziriOns BouzraraSarah BribierDelphine BrugierMelanie BrunelEida BuiAnne BuissonIryna BukreyevaCôme BureauJacques CadranelJohann CailholRuxandra CalinClara Campos VegaPauline CanavaggioMarta CancellaDelphine CantinAlbert CaoLionel CarbillonNicolas CarlierClementine CassardGuylaine CastorMarion CauchyOlivier ChaBenjamin ChaigneSalima ChallalKarine ChampionPatrick ChariotJulie ChasSimon ChauveauAnthony ChauvinClement ChauvinNathalie ChavarotKamélia ChebboutMustapha CheraiIlaria CherubiniAmelie ChevalierThibault ChiarabiniThierry ChinetRichard ChocronPascaline ChoinierJuliette ChommelouxChristophe ChoquetLaure ChoupeauxBenjamin ChoustermanDragosmarius CiocanAda ClarkeGaëlle ClavereFlorian ClavierKarine ClementSebastien ClercYves CohenFleur CohenAdrien CohenAudrey CoillyHester ColbocPauline ColinMagalie ColletCloé ComarmondEmeline CombaconAlain CombesCeline ComparonJean-Michel ConstantinHugues CordelAnne-Gael CordierAdrien CostantiniNathalie Costedoat ChalumeauCamille CouffignalDoriane CoupeauAlain CreangeYannie Cuvillier LamarreCharlène da SilveiraSandrine Dautheville Guibal El KayaniNathalie de CastroYann De RyckeLucie del PozoQuentin DelannoyMathieu DelayRobin DelerisJuliette DelforgeLaëtitia DelphineNoemie DemareSophie DemeretAlexandre DemouleAurore DeniauFrançois DépretSophie DerolezOuda DerradjiNawal DerridjVincent DescampsLydia DeschampsCeline DesconcloisCyrielle DesnosKarine DesonginsRobin DhoteBenjamin DialloMorgane DidierMyriam DiemerStephane DiezJuliette Djadi-PratFatima-Zohra Djamouri MonnorySiham DjebaraNaoual DjebraMinette DjietcheuHadjer DjillaliNouara DjouadiSeverine DonnegerCatarina dos SantosNathalie DournonMartin DresLaura DroctoveMarie DrogreyMargot DropyElodie DrouetValérie DubosqEvelyne DubreucqEstelle DubusBoris DuchemannThibault DuchenoyEmmanuel DudoignonRomain DufauFlorence DumasClara DuranEmmanuelle DuronAntoine DurrbachClaudine DuvivierNathan EbsteinJihane El KhalifaAlexandre ElabbadiCaroline ElieGabriel ErnotteAnne EslingMartin EtienneXavier EyerMuriel Sarah FartoukhTakoua FayaliMarion FermautArianna FiorentinoSouha FlissMarie-Céline FournierBenjamin FournierHélène FrancoisOlivia FreynetYvann FrigoutIsaure FromontAxelle FuentesThomas FuretJoris GalandMarc GarnierAgnes GaubertStéphane GaudrySamuel GaugainDamien GauthierMaxime GautierSophie Georgin-LavialleDaniela GerominMohamed GhalayiniBijan GhalehMyriam GhezalAude GibelinLinda GimenoBenoit GirardBénédicte Giroux LeprieurDoryan GomesElisabete Gomes-PiresAnne GougeAmel GoujaHelene GouletSylvain GoupilJeanne Goupil de BouilleJulien GrasSegolene GreffeLamiae GrimaldiPaul GuedeneyBertrand GuidetMatthias GuilloMariechristelle GulczynskiTassadit HadjamDidier HaguenauerSoumeya HammalNadjib HammoudiOlivier HanonAnarole HarroisCoraline HautemGuillaume HékimianNicholas HemingOlivier HermineSylvie HoMarie HoullierBenjamin HuotTessa HuscenotWafa Ibn SaiedGhilas IkherbaneMeriem ImarazenePatrick IngilizLina IratniStephane JaureguiberryJean-Francois Jean-MarcDeleena JeyarajasinghamPauline JouanyVeronique JouisClement JourdaineOuifiya KafifRim KallalaSandrine KatsahianLilit KelesyanVixra KeoFlora KetzWarda KhamisEnfel KheliliMehdi KhellafChristy Gaëlla Kotokpo YoukouIlias KounisGaelle KpalmaJessica KrauseVincent LabbeKarine LacombeJean-Marc LacorteAnne Gaelle LafontEmmanuel LafontLynda LaghaLionel LamhautAymeric LancelotCecilia LandmanFanny LanternierCecile LarchevequeCaroline Lascoux CombeLudovic LasselBenjamin LaverdantChristophe LavergneJean-Rémi LavillegrandPompilia LazureanuLoïc Le GuennecLamia LeberreClaire LeblancMarion LeboyerFrancois LecomteMarine LecorreRomain LeenhardtMarylou LefebvreBénédicte LefebvrePaul LegendreAnne LegerLaurence LegrosJustyna LegrosseSébastien LehuunghiaJulien LemarecJeremie Leporrier-ExtManon LeseinHubert LesurVincent LevyAlbert LevyEdwige LopesAmanda LopesVanessa LopezJulien LopintoOlivier LortholaryBadr LouadahBénédicte LozeMarie-Laure LucasAxelle LucasamichiLiem Binh LuongArouna Magazimama-ExtDavid MaingretLakhdar MameriPhilippe ManivetCylia MansouriEstelle MarcaultJonathan MareyNathalie MarinClémence MaroisOlivier MartinLou MartineauCannelle Martinez-LopezPierre MartyniuckPauline Mary de FarcyNessrine MarzoukRafik MasmoudiAlexandre MebazaaFrédéric MechaiFabio MecozziChamseddine MediouniBruno MegarbaneMohamed MeghadechaÉlodie MejeanArsène MékinianNour Mekki AbdelhadiRania MekniThinhinan Sabrina MelitiBreno Melo LimaParis MengSoraya MerbahFadhila MessaniYasmine MessaoudiBaboo-Irwinsingh MewasingLydia MezianeCarole Michelot-BurgerFrançoise MignotFadi Hillary MinkaMakoto MiyaraPierre MoineJean-Michel MolinaAnaïs Montegnies-BouletAlexandra MontiClaire MontlahucAnne-Lise MontoutAlexandre MooresCaroline MorbieuHelene MorteletteStéphane MoulyRosita MuzaffarCherifa Iness NacerddineMarine NadalHajer NadifKladoum NassarmadjiPierre NatellaSandrine NdingamondzeStefan NeraalCaroline NguyenBao N’guyenIsabelle Nion LarmurierLuc NlomenyengueNicolas NoelHilario NunesEdris OmarZineb OuazeneElise OuedraogoWassila OuelaaAnissa OukhedoumaYasmina Ould AmaraHerve OyaJohanna OzielThomas PadillaElena PaillaudSolenne PaivaBeatrice ParfaitPerrine ParizeChristophe ParizotAntoine ParrotArthur PavotLaetitia PeaudecerfFrédéric PeneMarion PepinJulie PernetClaire PerninMylène PetitOlivier PeyronyMarie-Pierre PietriOlivia PietriMarc Pineton de ChambrunMichelle PinsonClaire PintadoValentine PiquardChristine PiresBenjamin PlanquetteSandrine PoirierAnne-Laure PomelStéphanie PonsDiane PonscarmeAnnegaelle PourcelotValérie PourcherAnne PouvaretFlorian PreverMiresta PrevilonMargot PrevostMarie-Julie ProvoostCyril QuemeneurCédric RafatAgathe RamiBrigitte RanqueMaurice RaphaelJean Herle RaphalenAnna RastoinMathieu RauxAmani RebaiMichael RebyAlexis RégentAsma RegragMatthieu Resche-RigonQuentin RessaireChristian RichardMariecaroline RichardMaxence RobertBenjamin RohautCamille Rolland-DebordJacques RopersAnne-Marie Roque-AfonsoCharlotte RossoMélanie RousseauxNabila RousseauxSwasti RouxLorène RouxClaire RouzaudAntoine RozesEmma RubensteinJean-Marc SabateSheila SabetSophie-Caroline SacleuxNathalie Saidenberg KermanachFaouzi SalibaDominique Salmon-CéronLaurent SavaleGuillaume SavaryRebecca SberroAnne ScemlaFrederic SchlemmerMathieu SchwartzSaïd SedfiSamia Sefir-KribelPhilippe SeksikPierre SellierAgathe SelvesNicole SembachLuca 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ZwindermanMatthijs BrouwerW. Joost WiersingaAlexander VlaarDiederik van de BeekMiranda TompkinsCamille AlbaAndrew SnowDaniel HupaloJohn RosenbergerGauthaman SukumarMatthew WilkersonXijun ZhangJustin LackAndrew OlerKerry DobbsJeffrey DanielsonAndrea BiondiLaura Rachele BettiniMariella D’angio’Ilaria BerettaLuisa ImbertiAlessandra SottiniVirginia QuaresimaEugenia Quiros-RoldanCamillo RossiIsabelle MeytsShen-Ying ZhangAnne PuelLuigi NotarangeloStephanie Boisson-DupuisHelen SuBertrand BoissonEmmanuelle JouanguyJean-Laurent CasanovaQian ZhangLaurent AbelAurélie CobatPierre-Emmanuel Morange
• Organismes : Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris] Centre de référence, d’innovation, d’expertise et de transfert Génétique Evolutive Humaine - Human Evolutionary Genetics Immunologie intégrative des tumeurs et immunothérapie des cancers Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Immuno-Rhumatologie Moléculaire Immuno-Rhumatologie Moléculaire Immuno-Rhumatologie Moléculaire Centre International de Recherche en Infectiologie Virology and human respiratory Pathologies - Virology and human respiratory Pathologies [CIRI]
• Publié dans Genome Medicine le 24/10/2020

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Résumé : Background - We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods - We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results - No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P = 1.1 × 10) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3-8.2], P = 2.1 × 10). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1-2635.4], P = 3.4 × 10), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3-8.4], P = 7.7 × 10). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10). Conclusions - Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

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Fichiers liés : s13073-023-01173-8.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Brad RovinJonathan BarrattHiddo HeerspinkCharles AlpersStewart BielerDong-Wan ChaeUlysses DivaJürgen FloegeLoreto GesualdoJula InrigDonald KohanRadko KomersLaura Ann KooiengaRichard LafayetteBart MaesRobert MałeckiAlex MercerIrene NoronhaSe Won OhChen Au PehManuel PragaPriscila PreciadoJai RadhakrishnanMichelle RheaultWilliam RoteSydney TangVladimir TesarHoward TrachtmanHernán TrimarchiJames TumlinMuh Geot WongVlado PerkovicIsabella AbbascianoCatarina AbrantesSimone AccarinoSharon AdlerAnnika AdobergRouzbeh AfsariSyeda AhmadJafar AhmedWooin AhnBamidele AjayiDariusz AksamitSaif Al ChalabiEric AlamartineBassam AlchiMohammad AliRoberta AliottaSalem AlmaaniCatarina AlmeidaEdgar AlmeidaFrancisco de la Prada AlvarezPatricia AlvesFrancesca AnneseGerald AppelAlberto Ortiz ArduanMaria ArenaMarta Calvo ArevaloDariush ArfaaniaCarlos AriasEmma Calatayud AristoyEgle AsakieneSarah AshleyAli AssefiAlba AtenzaAsta AuerbachHanna Augustyniak-BartosikMonroy AvellaJonathan Ayling-SmithIsabelle AyoubChristine AyvazyanRocco BaccaroAsha BaileyBruce BakerSaravanan BalamuthusamyJose BallarinRui BarataJerko BarbicDunja BarisicJonathan BarrattJose Carlos de Jesus BarretoClara BarriosMirco BelingheriAnna BenesovaAna Avila BernabeuWanja BernhardtShamik BhadraLuigi BianconeAnne BlanchardElena BoaglioDavide BolignanoAndrew BombackGustavo Andres Useche BonillaMonica BordoliBhadran BoseNeil BoudvilleDonald BrandonDonald BrandonKaren BrownChristian BroyetThomas BucknallAlexandre BuffetInga Arune BumblyteManuel BurdeseNatalia Allende BurgosNatalia Allende BurgosLaure BurguetStephane BurteyMartin BuschFigen CakirogluVictoria CampbellPietro CanettaFlavia CapaccioJuan CarbonellFilipa CardosoClara Garcia CarroRobert CarrollPierre-Louis CarronNazareno CarulloMatthias CassiaDawn CasterBelen Vizcaino CastilloDavide CatucciAndrea CavalliDong-Wan ChaeAron ChakeraDoris ChanGary Chi Wang ChanAnthony Ting Pong ChanLai Wan ChanJae Hyun ChangMing-Shan ChangFiona ChapmanChaim CharytanAsghar ChaudhryMelissa CheethamCheng-Hsu ChenHsin-Yu ChenChien-Liang ChenHung-Yuan ChenHung-Chun ChenLeila ChenineSiu Fai CheungChee Kay CheungNoemie Chiche-JourdeHsien-Fu ChiuYen-Ling ChiuYi-Wen ChiuIan ChiuHoon Young ChoiKang-Ju ChouParamit ChowdhuryPradip ChowdhuryConstantina ChrysochouChukwuma ChukwuKa Yeong ChunWookyung ChungDominik CieniawskiGuillaume ClaissePhilip ClaytonCatalina Martín ClearyNisha ClementToby CoatesChiara CognoLoredana CollaMichael CollinsMarco ColucciChristian CombeNicolino ComiRoderick ComunaleGabriel ContrerasBruce CooperGaia CoppockAna Cortesão CostaStefano CostanziMario CozzolinoSusan CrailLiliana CunhaElizabeth CurryTiane DaiErica DainaSam DaneshvariIndranil DasguptaLouise DasilvaRobert DavidsonAine Maire de BhailisValérie de PrécigoutMarc DecupereYahsou DelmasFrancesca DeodatoNeeraj DhaunAjay DhaygudeRanjit DhelariaFederica Di MaioMaria Angeles Goicoechea DiezhandinoZivka DikaMiriana DinicIan DittmerMirela DobreGabriel DoctorGabriele DonatiPeter DoubelNicole DouthitDiliana DraganovaYelena DrexlerMartin DrinkovicKlara DrinovskaCaroline DudreuilhClement DumondIvan DurlenBertrand DussolMontserrat Diaz EncarnacionZoltan EndreJorge EnriqueYusuf EqbalJonathan ErlichVittoria EspositoCiro EspositoFaisal FakihHua-Chang FangAna FarinhaAaron FeardayJoana de Sousa Soares FelgueirasElzbieta FelicjanczukJoão Carlos FernandesSara FernandesAdriana FernandesJose Luño FernandezVictor FernandezMangalee FernandoAna Carolina FigueiredoEric FirreJürgen FloegeOliver FlossmannLauren FloydNuno FonsecaJose Nuno de Almeida Agapito FonsecaCeline FooteSuzanne ForbesAngel ForcenAlessia FornoniDavid FouassierIan FraserKa Shun Samuel FungMonica FurlanoTeresa FurtadoRajdeep GadhRoxane GaissetMartin GallagherJoana GameiroMuralikrishna GangadharanFabiola Alonso GarciaOlga Gracia GarciaGunjan GargCyril GarrousteArchana GautamAbdallah GearaColin GeddesLana GellineoMichael GermainLoreto GesualdoFarid GhalliFrancesco GiaroniHarold GilesAlastair GilliesAna Vilar GimenoAnnette GirardetJeffrey GlazeTze GohMario GoisChristopher GoldsmithElena GomaAna Marta GomesLuis Pedro Falcao GoncalvesSara GoncalvesJulita Gontarek-KacprzakCarlos GonzalezArun GopuNayan GowdaNicholas GrayBarbara GrecoHeather GreenClarisse GrezeSian GriffinSecundino Cigarran GuldrisUrsula Verdalles GuzmanJeffrey Tsun Kit HaAmanda HallPatrick HamiltonSeung Hyeok HanRobert HawsAshik HayatLauren HeathSven HeinrichsAndrew HendersonAmy HendersonElizabeth HendrenAnne-Elisabeth HengSalia Virxinia Pol HeresJohann Konstantin HerfurthEvangelina Merida HerreroTzung-Yo HoJonathan HoganBernd HohensteinPeter HollettIvica HorvaticBang-Gee HsuChia-Tien HsuChih-Yang HsuShih-Ping HsuChien-Wei HuangAmy HudsonChi-Chih HungShang-Jyh HwangDaw-Yang HwangYoung Youl HyunMadis IlmojaGeorgina IrishRadu JacobSadia JahanArunima JainSofie JamarAnna JanderHye Ryoun JangCatherine JankoMeg JardinePiotr JaskowskiGuillaume JeantetBojan JelakovicJunseok JeonJong Cheol JeongShilpanjali JesudasonArksarapuk JittiratSang-Kyung JoRachel JonesNarae JooSofia JorgeBruce JulianJiyong JungPraveena JyothinagaramJigar KadakiaFahameedah KamalDurga KanigicherlaSandra KaranovicAlexandre KarrasTheodoros KasimatisMohamad KassemSiddhartha KattamanchiChristopher KellerDubravka Trajbar KentricChristiane KettnerKassem KhalilDana KimSe Joong KimYeong Hoon KimYunmi KimHyung Wook KimSunggyun KimJwa-Kyung KimAejin KimMyung-Gyu KimCassandra KimberKathryn KlammAnnegret KochEric KoesterKulli KolvaldSui KonLaura Ann KooiengaSradha KotwalMagdalena KrajewskaKarolina KratkaAnoushka KrishnanRathika KrishnasamyThilo KruegerIvan KruljacSimone KulkaUlrich KunzendorfMei-Chuan KuoHung-Tien KuoSheng KuoLorraine Pui Yuen KwanNorbert KwellaBogna KwellaKay KyawAurore LabatRichard LafayetteMark LagattaChi Kwan Darwin LamMark LambieCamille LanaretFarah LatifMargo LauteWai Ping LawSarah LawmanMercedes Salgueira LazoHajeong LeeMoon Hyoung LeeKyu-Beck LeeHyung-Seok LeeJungeun LeeHyun Hee LeePo-Tsang LeeLiisi LeisWim LemahieuJanson LeungYan LiDavina Ngoi Wah LieHoward LiflandKadri LilienthalWai LimMonica LimardoMarine LivrozetSelena LonghiDaniela LopesJose Antonio LopesNathan LordeGrant LuxtonMingyao MaMachaiah MadhriraPhillip MadoniaBart MaesKumaradevan MahadevanAmar MahdiEamon MahdiNicolas MaillardDita MaixnerovaKarolina Majstorovic BaracRobert MaleckiThomas MalfaitSilvia MalvicaSreedhar MandayamPaul ManleyNick MansfieldCarmelita MarcantoniChristophe MariatTamara Malek MarinLida Maria Rodas MarinPatrick MarkJoana MarquesEduardo Gutierrez MartinezStacy MartinezCatherine MassetIngrid MassonAmanda MatherThida Maung Maung MyintValentin MayetKieran MccaffertyEllen MccarthyStephen McdonaldKerri McgrealKellyn McmahonAndrew McnallyEmily McquarrieAllyson MedinaGert MeeusKshama MehtaElder MendozaMaria MenezesJerry MengPiergiorgio MessaAna MessiasPrzemyslaw MiarkaMarius MiglinasIvana MikacicAshraf MikhailMartina MilicevicRaffi MinasianMarcus MoellerHesham MoheyJavad MojarrabMaggie Ming Yee MokEduardo Parra MoncasiMartial MoonenWenceslao Adrian Aguilera MoralesEduardo Verde MorenoAntolina MorenoAdam MorrisDimitrios MoutzourisMercedes Gonzalez MoyaSimon MuchaMichela MusolinoPietro NapodanoAna NatarioLavinia NegreaBradley NelsonBrendon NeuenBritt NewsomeKit Chung Jack NgThu NguyenViet NguyenClementine NicoloMartin NitschkeEuan NobleEuan NobleFernando NolascoEmma O'LoneAdriana Sierra OchoaKook-Hwan OhSewon OhPedro OkohSara OmbeletMichelle O'ShaughnessyShih-Hsiang OuDavid PackhamAparna PadiyarMei-Fen PaiIrene Agraz PamplonaSzu-Yu PanBhavna PandyaFederica PapadiaClara PardinhasNishita ParikhSamir ParikhHyeong Cheon ParkJung Tak ParkLucia ParreiraPatrizia PasseriniRamachandra PatakMargret PateckiRajan PatelJusmin PatelMeera Patel SutharGemma PatellaArtashes PatrikyanDrasko PavlovicWilliam PaxtonChen PehYonatan PelegJosep Miquel Blasco PelicanoYu-Sen PengManuel Pereira de VicenteJonay Pantoja PerezErika PerezAna Perez de JoseMaría Vanessa Pérez GómezLeticia Perez LlunaUsha PeriNorberto PericoCarole PhilipponnetElaine PhuaJulia PielUnnikrishnan PillaiHelen PilmoreDjuro PlavljanicMercedes Velo PlazaCarol PollockArvind PonnusamySerena PontiThomas PowellNishigandha PradhanRaul Fernandez PradoIngrid PrkacinRishi PruthiDan PughSarah QuinnLuis QuintanaLathika RaakeshKannaiyan RabindranathLuc RadermacherJai RadhakrishnanOmar Sherin Ibrahim RagyRitesh RaichoudhuryMario RaimundoPaolo RandoneMona RazavianHelmut ReichelMarina ReisGiuseppe RemuzziAnnie ReynoldsAnna RicchiutoIvon Maritza Bobadilla RicoClaire RigothierAngus RitchieMaria Antonieta Azancot RiveroDana RizkHan RoAlfred RodriguezEva Rodriguez GarciaSimon RogerMohammad RonyMai RosenbergStephane RoueffBrad RovinSarah RoxburghMario RuizHelena Marco RusinolIvan RychlikHelena SáTania SalehiMaria Dolores Sánchez de la NietaSilja SandenLina SantockienePatricia Valerio SantosIara da Silva SantosMari SargsyanFranziska SarnowSebahat SatEwa SatoraAna SavukMatthew SayerGeorg SchlieperMandy SchlosserHans Schmidt-GuertlerOlivier SchockaertKevin SchulteLisa SchulzHaresh SelvaskandanDavid SempleShaundeep SenElviira SeppetAntonio Galan SerranoJean-Emmanuel SerreAngel SevillanoSapna ShahYvonne ShenBrittany SheridanKai-Hsiang ShuFord SightlerSónia SilvaArnold SilvaSmeeta SinhaAmanda SiriwardanaZvonimir SitasCarmen SivoPeter SizelandCathylee SlyPriscilla SmithBrian SnowElsa Sofia Quadrado SoaresAndrea SolazzoElena Gutierrez SolisLaurence SolomonYoung Rim SongHelena SousaBruce SpinowitzElizabeth StallworthyEleni StamellouMalgorzata StanczykStefanie StangenbergMarija StankovicAsta StankuvieneEmma Diletta SteaTomasz StomporJoshua StorrarJames SullivanWladyslaw SulowiczIrina SuyumovaCheuk Chun SzetoEsther TamaritEddie TanMay TanSydney Chi Wai TangHon TangCatarina TeixeiraKadri TellingNatalia Ramos TerradesVladimir TesarDidem TezEric ThervetDamien ThibaudinMark ThomasNikhil ThyagarajanMarcin TkaczykMassimo TorreggianiMatias TrilliniShang-Feng TsaiWan-Chuan TsaiJer-Chia TsaiPo-Yu TsengJames TumlinKuei-Ting TungAngus TurnbullSuneel UdaniJana UhlinovaKristin UntFederica UrciuoloAn VanackerBert VandewieleAlvaro VazKristi VeermaeLiesbeth ViaeneAlvita VickieneSara ViganoMaria Antonia Munar VilaEswari VilayurCaridad Martinez VillanuevaCristina Medrano VillarroyaAlejandro Soria VillenVeronica ViramontesCaterina VitaDunja VujcicMona WahbaSusan WanChih-Hsien WangXavier WarlingGerald WatersJane WaughLea WeilandStefan WeinerThomas WeinreichStephan Christian WerthOlivia WickensVidu WijeratneKaren WilderLisa WillcocksAllister WilliamsAgata WiniarskaNikolaus WirtzLothar WolfGunter WolfMuh Geot WongYick Hei WongSze Ho Sunny WongBiruh WorkenehMing-Ju WuHon-Yen WuRoger WyndhamJihyun YangJu-Yeh YangChii YeapKa Fai YimKenneth YongTae-Hyun YooSonguk YoonTung-Min YuTak Tai Andrew YueMichel ZakariUrte ZakauskienePhilippe ZaouiJustyna ZbrzezniakDorota ZielinskaCarlotta Federica Zizzi
• Organismes : The Ohio State University [Columbus] University of Leicester University of Groningen [Groningen] University of New South Wales [Sydney] KI Editorial Board Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro Division of Nephrology Stanford School of Medicine [Stanford] Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias Service Néphrologie, Hémodialyses [CHU Clermont-Ferrand]
• Publié dans The Lancet le 02/11/2020

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• Type de publi. : Rapport
• Date de publi. : 01/12/2023
• Auteurs : Florence GuillotPhilippe PergentAdeline BéaJean CataloCharles PeytavieJean SoulatSophie CornardeauMarie-Louise BouetFrancis DieulafaitRadiocarbon Poznan LaboratoryPierre Bordas
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives Centre Michel de Boüard - Centre de recherches archéologiques et historiques anciennes et médiévales Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives

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Fichiers liés : PCR+FP Penne 2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/11/2023
• Auteurs : Stephan EhrmannFrançois BarbierJulien DemiselleJean-Pierre QuenotJean-Etienne HerbrechtDamien RouxJean-Claude LacheradeMickaël LandaisPhilippe SeguinDavid SchnellAnne VeinsteinPhilippe GouinSigismond LasockiQin LuGaëtan BeduneauMartine FerrandiereGaëtan PlantefèveClaire Dahyot-FizelierNader ChebibEmmanuelle MercierNathalie Heuzé-Vourc’hRenaud RespaudNicolas GrégoireDenis GarotMai-Anh NayFerhat MezianiPascal AndreuRaphaël Clere-JehlNoémie ZucmanMarie-Ange AzaïsMarjorie Saint-MartinCharlotte Salmon GandonnièreDalila BenzekriHamid MerdjiElsa Tavernier
• Organismes : Centre d’Etude des Pathologies Respiratoires [Tours] Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Regional d'Orléans Nanomédecine Régénérative CHU Dijon Hôpital de Hautepierre [Strasbourg] Hôpital Louis Mourier - AP-HP [Colombes] Institut Necker Enfants-Malades Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier d'Angoulême Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Archéologies et Sciences de l'Antiquité Centre Hospitalier Universitaire d'Angers CHU Pitié-Salpêtrière [AP-HP] Groupe de Recherche sur le Handicap Ventilatoire CHU Rouen CHU Trousseau [Tours] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Hôpital de la Croix-Rousse [CHU - HCL] Université Claude Bernard Lyon 1 Centre Hospitalier Régional Universitaire de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Centre d’Investigation Clinique [Tours] CIC 1415 methodS in Patients-centered outcomes and HEalth ResEarch
• Publié dans New England Journal of Medicine le 29/10/2020

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Résumé : Background: Whether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear. Methods: In this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive inhaled amikacin at a dose of 20 mg per kilogram of ideal body weight once daily or to receive placebo for 3 days. The primary outcome was a first episode of ventilator-associated pneumonia during 28 days of follow-up. Safety was assessed. Results: A total of 850 patients underwent randomization, and 847 were included in the analyses (417 assigned to the amikacin group and 430 to the placebo group). All three daily nebulizations were received by 337 patients (81%) in the amikacin group and 355 patients (83%) in the placebo group. At 28 days, ventilator-associated pneumonia had developed in 62 patients (15%) in the amikacin group and in 95 patients (22%) in the placebo group (difference in restricted mean survival time to ventilator-associated pneumonia, 1.5 days; 95% confidence interval [CI], 0.6 to 2.5; P = 0.004). An infection-related ventilator-associated complication occurred in 74 patients (18%) in the amikacin group and in 111 patients (26%) in the placebo group (hazard ratio, 0.66; 95% CI, 0.50 to 0.89). Trial-related serious adverse effects were seen in 7 patients (1.7%) in the amikacin group and in 4 patients (0.9%) in the placebo group. Conclusions: Among patients who had undergone mechanical ventilation for at least 3 days, a subsequent 3-day course of inhaled amikacin reduced the burden of ventilator-associated pneumonia during 28 days of follow-up. (Funded by the French Ministry of Health; AMIKINHAL ClinicalTrials.gov number, NCT03149640; EUDRA Clinical Trials number, 2016-001054-17.).

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/11/2023
• Auteurs : Mohamed Said OughouEric BiotNicolas ArnaudAude Maugarny-CalèsPatrick LaufsPhilippe AndreyJasmine Burguet
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

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Résumé : Morphogenesis is a process that spans several orders of magnitude in both time and space. Because it is generally impossible to follow developing organs all along growth, analyses typically rely on static data sampled at different developmental stages. We propose a model-based approach for the accurate dating of organs, allowing spatio-temporal reconstruction of organ morphogenesis over unlimited time windows, based on static data collected from different individuals. Although considered leaves in wild-type and mutant plants displayed contrasted final shapes and sizes, we revealed invariant, iterated developmental schemes, and identical critical time points, suggesting conserved morphogenetic modules. We provided evidence that modules determining local features may act independently of global leaf growth. In particular, we showed that serrations developing at different times and/or in different leaves grow in a remarkably synchronized way. In addition, graded differences in growth dynamics and final shapes of successive leaves suggest continuous variations in module expression. Altogether, we illustrated that our strategy is powerful to finely dissect multi-scale morphogenetic processes.

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