Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 02/01/2024
• Auteurs : Arthur OrieuxRenaud PrevelMargot DumeryJean-Baptiste LascarrouNoémie ZucmanFlorian ReizinePierre FillâtreCharles DetollenaereCédric DarreauNadiejda AntierMélanie Saint-LégerGuillaume SchnellBéatrice La CombeCharlotte GuesdonFranklin BrunaAntoine GuillonCaroline VarillonOlivier LesieurHubert GrandBenjamin BertrandShidasp SiamiPierre OudevilleCéline BesnardRomain PersichiniPierrick BauduinMartial ThyraultMathieu EvrardDavid SchnellJohann AuchabieAdrien AuvetJean-Philippe RigaudPascal BeuretMaxime LeclercAsaël BergerOmar Ben Hadj SalemJulien LorberAnnabelle StoclinOlivier GuissetLéa BientzPierre KhanVivien GuillotinJean-Claude LacheradeAlexandre Boyer
• Organismes : CHU de Bordeaux Pellegrin [Bordeaux] Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Hôpital Saint-André [Bordeaux] Hôpital Pellegrin Hôpital Saint-André [Bordeaux] Hôpital Pellegrin Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance Centre Hospitalier d'Annecy Genevois Centre Hospitalier Bretagne Atlantique (Vannes-Auray) Hôpital de Saint-Brieuc [Hôpital Yves Le Foll] Centre Hospitalier Boulogne-sur-mer Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Alès-Cévennes Centre Hospitalier de Périgueux Groupe Hospitalier du Havre Groupe Hospitalier Bretagne Sud Centre hospitalier de Pau Centre Hospitalier Alpes Léman Centre d’Etude des Pathologies Respiratoires [Tours] Hôpital Alexandra Lepève – Centre Hospitalier de Dunkerque Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Centre Hospitalier Libourne Centre Hospitalier Intercommunal de Toulon [La Seyne-sur-Mer] Centre Hospitalier Sud Essonnes Dourdan Etampes Groupe hospitalier de la région de Mulhouse et Sud-Alsace Centre Hospitalier Régional d'Orléans Centre hospitalier de Saintes CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Groupe Hospitalier Nord Essonne [Longjumeau] Centre Hospitalier de Lens Centre Hospitalier d'Angoulême Centre Hospitalier de Cholet Centre Hospitalier Dax - Côte d'Argent Centre hospitalier de Dieppe Centre Hospitalier de Roanne Centre Hospitalier Mémorial France États-Unis de Saint-Lô Centre Hospitalier de Haguenau Centre Hospitalier intercommunal de Meulan les Mureaux Centre hospitalier de Saint-Nazaire Département interdisciplinaire d’organisation des parcours patients [Gustave Roussy] Hôpital Pellegrin Hôpital Saint-André [Bordeaux] Microbiologie Fondamentale et Pathogénicité Hôpital Haut-Lévêque [CHU Bordeaux] Hôpital Pellegrin Hôpital Saint-André [Bordeaux] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Hôpital Pellegrin Hôpital Saint-André [Bordeaux] Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux]
• Publié dans Critical Care le 31/10/2020

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Résumé : Background Group A Streptococcus is responsible for severe and potentially lethal invasive conditions requiring intensive care unit (ICU) admission, such as streptococcal toxic shock-like syndrome (STSS). A rebound of invasive group A streptococcal (iGAS) infection after COVID-19-associated barrier measures has been observed in children. Several intensivists of French adult ICUs have reported similar bedside impressions without objective data. We aimed to compare the incidence of iGAS infection before and after the COVID-19 pandemic, describe iGAS patients’ characteristics, and determine ICU mortality associated factors. Methods We performed a retrospective multicenter cohort study in 37 French ICUs, including all patients admitted for iGAS infections for two periods: two years before period (October 2018 to March 2019 and October 2019 to March 2020) and a one-year after period (October 2022 to March 2023) COVID-19 pandemic. iGAS infection was defined by Group A Streptococcus isolation from a normally sterile site. iGAS infections were identified using the International Classification of Diseases and confirmed with each center's microbiology laboratory databases. The incidence of iGAS infections was expressed in case rate. Results Two hundred and twenty-two patients were admitted to ICU for iGAS infections: 73 before and 149 after COVID-19 pandemic. Their case rate during the period before and after COVID-19 pandemic was 205 and 949/100,000 ICU admissions, respectively ( p < 0.001), with more frequent STSS after the COVID-19 pandemic (61% vs. 45%, p = 0.015). iGAS patients ( n = 222) had a median SOFA score of 8 (5–13), invasive mechanical ventilation and norepinephrine in 61% and 74% of patients. ICU mortality in iGAS patients was 19% (14% before and 22% after COVID-19 pandemic; p = 0.135). In multivariate analysis, invasive mechanical ventilation (OR = 6.08 (1.71–21.60), p = 0.005), STSS (OR = 5.75 (1.71–19.22), p = 0.005), acute kidney injury (OR = 4.85 (1.05–22.42), p = 0.043), immunosuppression (OR = 4.02 (1.03–15.59), p = 0.044), and diabetes (OR = 3.92 (1.42–10.79), p = 0.008) were significantly associated with ICU mortality. Conclusion The incidence of iGAS infections requiring ICU admission increased by 4 to 5 after the COVID-19 pandemic. After the COVID-19 pandemic, the rate of STSS was higher, with no significant increase in ICU mortality rate.

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Fichiers liés : s13054-023-04774-2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Jean FurstossPierre HirelPhilippe CarrezK. GourietVictoire Meko-FotsoPatrick Cordier
• Organismes : Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207 Unité Matériaux et Transformations - UMR 8207
• Publié dans Computational Materials Science le 30/10/2020

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Résumé : In this work, we investigate twist grain boundary (GB) energies and structures in Mg2SiO4 forsterite using atomistic simulations. We first present a new bond orientational order parameter allowing to highlight disordered regions in this low-symmetry crystal for which classical visualization tools are ineffective. Then we examine three GB planes, (010), (120) and (001), corresponding to the most favorable free surfaces of this crystal. We show that twist GB follow the same energy ordering as corresponding free surfaces. In addition, except for some misorientation angles and for the (120) GB plane, GB energies and structures are quite insensitive to microscopic translational degrees of freedom. The dislocation composition of low-angle twist GB can be related to ?-surfaces in the corresponding planes, and are in good agreement with first-principle calculations. It is also shown that the dislocation core structures in low angle twist GB can strongly differ from the ones of intracrystalline dislocations.

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Fichiers liés : Furstoss-et-al(2024)TwistGrainBoundariesForsterite.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Marjorie UbertosiGilles BrunschwigThierry CastelDenis ChapuisJean-Philippe GoronMaé GuinetAnne JarousseAnnabelle LarmureChristophe LecomteJean- Pierre ManteauxAymeric MondièreClaire MosnierBernard NicolardotMarie- Sophie PetitWilfried QueyrelCorinne TanguyEglantine ThieryMarie-Hélène VergotePatrick VeyssetAnne-Sophie VoisinCandice Laroche
• Organismes : Agroécologie [Dijon] Unité Mixte de Recherche sur les Herbivores - UMR 1213 Centre de Recherches de Climatologie [UMR Biogéosciences] Chambre d'Agriculture de Saône-et-Loire PEP bovins lait chambre agriculture Chambre d'Agriculture de l'Isère Agroécologie [Dijon] Unité Mixte de Recherche sur les Herbivores - UMR 1213 Agroécologie [Dijon] Agroécologie [Dijon] Chambre d’Agriculture de la Drôme Unité Mixte de Recherche sur les Herbivores - UMR 1213 Unité Mixte de Recherche sur les Herbivores - UMR 1213 Agroécologie [Dijon] Chambre Régionale d’Agriculture de Bourgogne Franche-Comté Agroécologie [Dijon] Centre d'économie et de sociologie rurales appliquées à l'agriculture et aux espaces ruraux Unité Mixte de Recherche sur les Herbivores - UMR 1213 Centre d'économie et de sociologie rurales appliquées à l'agriculture et aux espaces ruraux Unité Mixte de Recherche sur les Herbivores - UMR 1213 Agroécologie [Dijon] Centre d'économie et de sociologie rurales appliquées à l'agriculture et aux espaces ruraux Institut Agro Dijon
• Publié dans Innovations Agronomiques le 24/10/2020

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Résumé : In the Burgundy Franche-Comté and Auvergne-Rhône-Alpes French regions, the regional projects POEETE and ProSys dealt with the adaptation of agricultural production systems to changes in the environmental, agricultural and social context, focusing on different scales and taking into account the context of reduced inputs and the search for autonomy by introducing legume crops. The processed data come from various approaches: surveys, experimental monitoring, modelling approach... The impact of climate change on the ecophysiology of legume crops was addressed through a model plant, the pea, and two criteria: flowering date and frost stress. To ensure the sustainability of mixed farming operations, new forage mixtures have been tested. Then the ecosystemic services provided by legume crops were studied: precedent effect, nitrogen content and interest in improving the protein autonomy of farms. The prioritization of ecosystem services in the adoption of these crops was studied via surveys of pioneer farmers in the region. Finally, the agroecological transition was studied via questions about the complementarity of mixed farming and livestock production, the performance of cropping systems including legume crops, farmers' motivations to develop more agro-ecological practices and the study of model farm trajectories.

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Fichiers liés : 2024_Ubertosi_Innovations Agronomiques_Vol 86_GB.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Laetitia LengeléYves RollandLaurent O MartinezSophie Gillette-GuyonnetAngelo PariniAlexandre LucasBruno VellasPhilipe Barreto de SoutoIsabelle CarriéLauréane BrigitteCatherine FaisantFrançoise LalaJulien DelrieuHélène VillarsEmeline CombrouzeCarole BadufleAudrey ZuerasSandrine AndrieuChristelle CantetChristophe MorinGabor Abellan van KanCharlotte DupuyCéline CaillaudPierre-Jean OussetFrançoise LalaSherry WillisSylvie BellevilleBrigitte Gilbert-DussardierFrancine FontaineJean-François DartiguesIsabelle MarcetFleur DelvaAlexandra FoubertSandrine CerdaCorinne CostesOlivier RouaudPatrick ManckoundiaValérie QuipourtSophie MarilierEvelyne FranonLawrence BoriesMarie-Laure PaderMarie-France BassetBruno LapoujadeValérie FaureMichael Li Yung TongChristine Malick-LoiseauEvelyne Cazaban-CampistronFrançoise DesclauxColette BlatgeThierry DantoineCécile Laubarie-MouretIsabelle SaulnierJean-Pierre ClémentMarie-Agnès PicatLaurence Bernard-BourzeixStéphanie WilleboisIléana DésormaisNoëlle CardinaudMarc BonnefoyPierre LivetPascale RebaudetClaire GédéonCatherine BurdetFlavien TerracolAlain PesceStéphanie RothSylvie ChaillouSandrine LouchartKristelle SudresNicolas LebrunNadège Barro-BelayguesJacques TouchonKarim BennysAudrey GabelleAurélia RomanoLynda TouatiCécilia MarelliCécile PaysPhilippe RobertFranck Le DuffClaire GervaisSébastien GonfrierYannick GasnierSerge BordesDanièle BegorreChristian CarpuatKhaled KhalesJean-François LefebvreSamira Misbah El IdrissiPierre SkolilJean-Pierre SallesCarole DufouilStéphane LehéricyMarie ChupinJean-François ManginAli BouhayiaMichèle AllardFrédéric RicolfiDominique DuboisMarie Paule Bonceour MartelFrançois CottonAlain BonaféStéphane ChanaletFrançoise HugonFabrice BonnevilleChristophe CognardFrançois CholletPierre PayouxThierry VoisinSophie PeifferAnne HitzelMichèle AllardMichel ZancaJacques MonteilJacques DarcourtLaurent MolinierHélène DerumeauxNadège CostaBertrand PerretClaire VinelSylvie Caspar-BauguilPascale Olivier-AbbalChristelle CantetNicola Coley
• Organismes : Gérontopôle Gérontopôle Equipe AGING (CERPOP) Institut des Maladies Métaboliques et Casdiovasculaires Gérontopôle Equipe AGING (CERPOP) Institut des Maladies Métaboliques et Casdiovasculaires Institut des Maladies Métaboliques et Casdiovasculaires Gérontopôle Equipe AGING (CERPOP) Gérontopôle Equipe AGING (CERPOP) Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP) Centre de recherche en épidémiologie et santé des populations Centre Hospitalier Universitaire de Toulouse Equipe AGING (CERPOP) Centre Hospitalier Universitaire de Toulouse Laboratoire Eau Environnement et Systèmes Urbains IUT Sénart-Fontainebleau Université Paris Descartes - École de sages-femmes Baudelocque Institut de Recherche sur les CERamiques Centre Hospitalier Universitaire de Toulouse University of Washington [Seattle] Centre de recherche de l'Institut universitaire de gériatrie de Montreal Centre de recherche de l'Institut universitaire de gériatrie de Montreal Université du Québec à Montréal = University of Québec in Montréal Bordeaux population health Bordeaux population health Université Claude Bernard Lyon 1 Equipe EQUITY (CERPOP)
• Publié dans Journals of Gerontology Series A: Biological Sciences and Medical Sciences le 01/01/2003

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Résumé : Background: Weight and appetite regulation have been associated with the expression and secretion of ATPase inhibitory factor 1 (IF1) and growth differentiation factor-15 (GDF-15), 2 potential biomarkers for age-related mitochondrial dysfunction. The aim was to explore the associations between these biomarkers and nutritional variables in the Multidomain Alzheimer Preventive Trial study. Methods: IF1 and GDF-15 plasma levels were quantified at 1-year follow-up. The nutritional status was measured using the Mini Nutritional Assessment (MNA) score variation between baseline and 1- and 2-year visits; appetite loss was extracted from the MNA. Bodyweight was measured every 6 months until the third year and then yearly until the fifth year of follow-up, and weight loss was established if the loss was greater than 5% or 10% within the past 6 or 12 months, respectively. Bidirectional associations of IF1 and GDF-15 levels with malnutrition, appetite, and weight loss were examined. The interactions between individual IF1 and GDF-15 with sex were explored. Results: Four hundred and forty-eight participants had MNA data and 1 045 had weight loss data. All the associations between IF1 levels and the MNA score, appetite loss, and weight loss were nonsignificant. Higher GDF-15 levels were cross-sectionally associated with appetite loss at the first year of follow-up, and the GDF-15 highest quartile was associated with nearly 80% higher risks of weight loss over 4 years. Interactions between IF1 and GDF-15 levels, and between these 2 markers and sex were not significantly associated with the outcomes. Conclusions: GDF-15 plasma levels were related to key malnutrition criteria.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Catherine ReenaersD. EneaMaria NachuryDavid LaharieYoram BouhnikMathurin FumeryJean-Marc GornetAurélien AmiotRomain AltweggMartine de VosPhilippe MarteauArnaud BourreilleStéphane NanceyStéphanie ViennotE LouisMagali Svrcek
• Organismes : Centre Hospitalier Universitaire Sart Tilman CHU Saint-Antoine [AP-HP] Hôpital Claude Huriez [Lille] Service d'Hépato-Gastro-Entérologie Clinique Ambroise Paré [Centres Médico-Chirurgicaux Ambroise Paré, Pierre Cherest, Hartmann] Service d'Hépato Gastroenterologie [CHU Amiens-Picardie] Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Service d'hépato-gastro-entérologie Service d'Hépato-gastro-entérologie [APHP Kremlin-Bicêtre] CHU Montpellier = Montpellier University Hospital Ghent University Hospital = Hôpital Universitaire de Gand = Universitair Ziekenhuis Gent [Gent] CHU Saint-Antoine [AP-HP] Hôpital Hôtel-Dieu [CHU Nantes] Centre Hospitalier Lyon Sud [CHU - HCL] Clinique de l'Alma, Paris, France. CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire Sart Tilman CHU Saint-Antoine [AP-HP]
• Publié dans Journal of Crohn's and Colitis le 31/10/2020

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Résumé : Abstract Background Deep remission has become the target in the management of Crohn’s disease (CD). The role of histology in the management of CD has not yet been established. The aim of this work was to study the impact of histological inflammation on the risk of clinical relapse in patients with CD in clinical and endoscopic remission and to study the correlation between histology and endoscopic scores and biomarkers. Methods All patients included in STORI (1) were eligible for inclusion. Fecal calproptectin and colonoscopy with CDEIS calculation were performed at inclusion. Two biopsies, taken either from the most inflammed macroscopic area or from an area with previous inflammation in case of mucosal healing (MH) were prospectively performed. MH was defined by the absence of ulcers. Different histological scores were calculated by 2 independent pathologists: Robart, Geboes, modified Geboes, Nancy, and DCA-IBD scores. Histological remission was defined by Nancy=0 ; Geboes ≤2 ; modified Geboes of grade 0 ; Robarts ≤3, IBD-DCA of C≤1 and A=0. Clinical relapse was prospectively evaluated in the STORI trial as CDAI>250 or CDAI between 150 and 250 with an increase of 70 points during 2 successive weeks compared to the inclusion visit. (1) Louis E et al .Gastroenterology 2012 Results Eighty biopsies (22 ileal and 58 colonic) were available from 76/115 patients included in STORI. Among the 45 patients with MH, 30 had colonic biopsies, 11 had ileal biopsies and 4 had biopsies in both locations. Among colonic biopsies 68% had histological remission according to Nancy and modified Geboes scores, 65% according to DCA-IBD and Geboes scores and 71% according to Robarts score. Among ileal biopsies 53% had histological remission according to Nancy score, 47% according to Modified Geboes, Geboes and DCA-IBD scores, and 67% according to the Robarts score. Thirty-five patients (46%) experienced a clinical relapse during the follow-up including 16/45 (36%) and 19/31 (61%) in the group with MH and without MH respectively. Histological characteristics and histological scores were not predictive of clinical relapse. In the total cohort (n=76), the CDEIS score was correlated to Nancy (p<0,001, r=0,43), Geboes (p<0,001, r=0,47) and Robarts (p<0,001, r=0,45) scores. Fecal calprotectin was correlated to Nancy (p<0,001, r=0,48), Geboes (p<0,001, r=0,45) and Robarts (p<0,001, r=0,46) scores. The histological scores of Nancy, Robarts and Geboes were highly correlated (p<0,0001 ; r > 0,9). Conclusion Although correlated with endoscopy and biomarkers, histology was not predictive of clinical relapse in CD patients in clinical and endoscopic remission. These findings do not support the use of histology to predict clinical relapse in CD in clinical practice.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Anne-Laure MorinEmmanuelle BlancArmelle PhaliponPierre-Henri BertoyePhilippe AmielCécile ArtaudPhilippe BarthélemyElisabeth Botelho-NeversSoizic CourcierJean-Luc CracowskiFrançois EisingerRemi ForratAlina GruberEuzebiusz JamrozikOdile LaunayClaire Le JeunneDavid Simhon
• Organismes : Institut Pasteur [Paris] Pfizer Institut Pasteur [Paris] Ministère des Solidarités et de la Santé [Paris, France] Institut National de la Santé et de la Recherche Médicale AstraZeneca AP-HP - Hôpital Antoine Béclère [Clamart] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital Michallon Institut Paoli-Calmettes Sanofi-Aventis R&D GlaxoSmithKline University of Oxford Monash University CIC - Vaccinologie - APHP (Cochin - Pasteur) F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Hôpital Cochin [AP-HP] Galien Affaires [Paris]
• Publié dans Therapies le 04/10/2022

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Résumé : This round table is the result of an observation. The observation being that controlled human infection clinical trials (also called "infectious challenge" trials or "Controlled Human Infection Models", "CHIM") recommended or even encouraged in the context of vaccine developments in particular, are not carried out in France. However, there are no formal prohibitions within regulations or ethical principles, which point to the prior assessment of risks and benefits for individuals and for society. The participants in this Round Table thus wished to examine, through the prism of their respective disciplines, the scientific and medical relevance of conducting such trials in France and, if possible, to imagine the conditions under which they would be carried out, thus resulting in recommendations on (1) the advisability of their conduct in France (2), the conditions under which they would be implemented in terms of logistics and regulations, and (3) their social acceptability. The recommendations on which the participants of the Round Table came to an agreement are presented as the analysis progresses.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Sophie LarocheChetana LimClaire GoumardMichel RayarDaniel CherquiLaurence ChicheLouise BarbierEphrem SalaméJean-Yves MabrutMickael LesurtelStéphanie TruantEmmanuel BoleslawskiFabrice MuscariChristian HobeikaMircea ChiricaEmmanuel BucJean HardwigsenAstrid HerreroFrancis NavarroFrançois FaitotPhilippe BachellierJean-Marc RégimbeauAlexis LaurentDavid FuksOlivier SoubraneDaniel AzoulayÉric VibertOlivier ScattonFrancois CauchyTakeo NomiNassima OudafalBrice GayetTakayuki KawaiShohei KomatsuShinya OkumuraNicolo PetruccianiPetru O. BucurBoris TrechotJulio NunezMichele TedeschiMarc‐antoine AllardNicolas GolseOriana CiacioGabriella PittauAntonio CunhaRene AdamChristophe LaurentPauline LéourierLionel RebiboLorenzo FerreFrancois-Regis SoucheJohn ChauvatFrancois JehaesKayvan MohkamThevy HorFrancois PayePierre BalladurBertrand SucGuillaume MilletMehdi El AmraniCeline RatajczakKatia LecolleFrancois-Rene PruvotAli-Reza KianmaneshTatiana CodjiaLilian SchwarzEdouard GirardJulio AbbaChristian LetoublonAhmed BourasAntoine CarmeloCharles VanbruggheZineb CherkaouiXavier UnterteinerPatrick PessauxRiccardo MemeoEmilie LhermiteMarie BougardJulien BarbieuxUgo MarcheseJacques EwaldOlivier TuriniAlexandre ThobieBenjamin MenahemAndrea MulliriJean LubranoJohanna ZemourHerve FagotGuillaume PassotEmilie GregoireYves Le TreutDavid Patrice
• Organismes : CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Simplification des soins chez les patients complexes - UR UPJV 7518 Centre de Recherche Saint-Antoine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hépato-Biliaire [Hôpital Paul Brousse] Hôpital Haut-Lévêque - CHU de Bordeaux Hôpital Haut-Lévêque - CHU de Bordeaux Centre Hospitalier Régional Universitaire de Tours Hôpital de la Croix-Rousse [CHU - HCL] Service de chirurgie hepato-pancreato-biliaire Service de chirurgie hepato-pancreato-biliaire Hôpital Claude Huriez [Lille] Chirurgie Générale et Digestive [Rangueil] Service de chirurgie hepato-pancreato-biliaire Département d'hépato-gastroentérologie Service Chirurgie Digestive et Hépatobiliaire [CHU Clermont-Ferrand] Service chirurgie générale et transplantation hépatique, APHM, Hôpital La Timone, Marseille, France Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi] Département d'Hépato-Gastroentérologie et de Transplantation Hépatique [CHU Saint-Eloi] Hôpital de Hautepierre [Strasbourg] Hôpital de Hautepierre [Strasbourg] Chirurgie digestive [CHU Amiens] Simplification des soins chez les patients complexes - UR UPJV 7518 Service de chirurgie digestive Hôpital Cochin [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut Mutualiste de Montsouris Centre Hépato-Biliaire [Hôpital Paul Brousse] Centre Hépato-Biliaire [Hôpital Paul Brousse] CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche Saint-Antoine
• Publié dans HPB le 26/10/2020

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Résumé : Background: There are no data to evaluate the difference in populations and impact of centers with liver transplant programs in performing laparoscopic liver resection (LLR). Methods: This was a multicenter study including patients undergoing LLR for benign and malignant tumors at 27 French centers from 1996 to 2018. The main outcomes were postoperative severe morbidity and mortality. Results: A total of 3154 patients were included, and 14 centers were classified as transplant centers (N = 2167 patients, 68.7 %). The transplant centers performed more difficult LLRs and more resections for hepatocellular carcinoma (HCC) in patients who more frequently had cirrhosis. A higher rate of performing the Pringle maneuver, a lower rate of blood loss and a higher rate of open conversion (all p < 0.05) were observed in the transplant centers. There was no association between the presence of a liver transplant program and either postoperative severe morbidity (<10 % in each group; p = 0.228) or mortality (1 % in each group; p = 0.915). Conclusions: Most HCCs, difficult LLRs, and cirrhotic patients are treated in transplant centers. We show that all centers can achieve comparable safety and quality of care in LLR independent of the presence of a liver transplant program.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Laura PolivkaMarine MadrangeCristina Bulai-LivideanuStéphane BareteThomas BallulAntoine NeurazCeline GrecoJulie AgopianFabienne BrenetPatrice DubreuilCharles BurdetRichard LemalOlivier TournilhacLouis TerriouDavid LaunayLaurence BouilletClément GourguechonGhandi DamajLaurent FrenzelCécile MeniHassiba BouktitAnne Florence CollangeCaroline Gaudy-MarquesteMarie GousseffEdwige Le MouelMohamed HamidouAntoine NéelDana RantaRoland JaussaudPhilippe GuilpainDanielle CanioniThierry Jo MolinaJulie BruneauLudovic LhermitteNicolas GarcelonRose-Marie JavierFabien PelletierFlorence CastelainFrederique RetornazQuentin CabreraPatricia ZunicMarie Pierre GourinEwa Hainaut-WierzbickaJean-François ViallardChristian LavigneCyrille HoarauIsabelle DurieuMaël HeibligSophie Dimicoli-SalazarJosé Miguel Torregrosa-DiazAngèle SoriaMichel ArockOlivier LortholaryChristine BodemerOlivier HermineJulien Rossignol
• Organismes : Translational Research in Autoimmunity and Inflammation Group Centre de Recherche en Cancérologie de Marseille
• Publié dans Journal of Allergy and Clinical Immunology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Pierre-Régis BurgelKevin SouthernCharlotte AddyAlberto BattezzatiClaire BerryJean-Philippe BoucharaEdwin BrokaarWhitney BrownPilar AzevedoIsabelle DurieuMiquel EkkelenkampFelicity FinlaysonJulian FortonJohanna GardeckiPavla HodkovaGina HongJacqueline LowdonSu MadgeClémence MartinEdward MckoneAnne MunckChee OoiLucy PerremAmanda PiperAndrew PrayleFelix RatjenMargaret RosenfeldDon SandersCarsten SchwarzGiovanni TaccettiClaire E WainwrightNatalie WestMichael WilschanskiAmanda BevanCarlo CastellaniPavel DrevinekSilvia GartnerAndrea GramegnaElise LammertynBarry PlantAlan SmythSilke van Koningsbruggen-RietschelPeter Middleton
• Organismes : Institut Cochin Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Centre Hospitalier Universitaire d'Angers Research on Healthcare Performance Hospices Civils de Lyon Institut Cochin
• Publié dans Journal of Cystic Fibrosis le 01/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2024
• Auteurs : Julian TheurietGorka Fernandez-EulatePhilippe LatourTanya StojkovicMarion MasingueLéo VidoniEmilien BernardArnaud JacquierLaurent SchaefferEmmanuelle Salort-CampanaJean-Baptiste ChansonAleksandra Nadaj PaklezaAnne-Laure KaminskyJuliette SvahnVéronique ManelFrançoise BouhourAntoine Pegat
• Organismes : Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Institut de Myologie CHU Pitié-Salpêtrière [AP-HP] Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Groupement Hospitalier Lyon-Est Institut de Myologie CHU Pitié-Salpêtrière [AP-HP] Institut de Myologie CHU Pitié-Salpêtrière [AP-HP] Groupement Hospitalier Lyon-Est Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Groupement Hospitalier Lyon-Est Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Groupement Hospitalier Lyon-Est Hôpital de la Timone [CHU - APHM] Hôpitaux Universitaires de Strasbourg Hôpitaux Universitaires de Strasbourg Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Hôpital Femme Mère Enfant [CHU - HCL] Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Physiopathologie et génétique du neurone et du muscle / Pathophysiology and Genetics of Neuron and Muscle Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL]
• Publié dans European Journal of Human Genetics le 22/10/2020

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Résumé : Proximal spinal muscular atrophy (SMA) is defined by a degeneration of the anterior horn cells resulting in muscle weakness predominantly in the proximal lower limbs. While most patients carry a biallelic deletion in the SMN1 gene (localized in chromosome 5q), little is known regarding patients without SMN1-mutation, and a genetic diagnosis is not always possible. Here, we report a cohort of 24 French patients with non-5q proximal SMA from five neuromuscular centers who all, except two, had next-generation sequencing (NGS) gene panel, followed by whole exome sequencing (WES) if gene panel showed a negative result. The two remaining patients benefited directly from WES or whole genome sequencing (WGS). A total of ten patients with causative variants were identified, nine of whom were index cases (9/23 families = 39%). Eight variants were identified by gene panel: five variants in DYNC1H1, and three in BICD2. Compound heterozygous causative variants in ASAH1 were identified directly by WES, and one variant in DYNC1H1 was identified directly by WGS. No causative variant was found using WES in patients with a previous panel with negative results (14 cases). We thus recommend using primarily NGS panels in patients with non-5q-SMA and using WES, especially when several members of the same family are affected and/or when trio analyses are possible, or WGS as second-line testing if available.

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Fichiers liés : s41431-023-01407-8.pdf

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