Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 11/10/2023
• Auteurs : Elise DreanoPierre-Régis BurgelAurélie HattonNaim BouazzaBenoit ChevalierJulie MaceySylvie LeroyIsabelle DurieuLaurence WeissDominique GrenetNathalie StremlerCamille OhlmannPhilippe ReixMichele PorzioPauline Roux ClaudeNatacha RémusBenoit DouvrySylvie MontcouquiolLaure CossonJulie MankikianJeanne LanguepinVeronique HoudouinLaurence Le ClaincheAnne GuillaumotDelphine PouradierAdrien TissotPascaline PriouLaurent MélyFrederique ChedevergneMuriel LebourgeoisJean LebihanClémence MartinFlora ZavalaJennifer da SilvaLydie LemonnierMairead Kelly-AubertAnita GolecPierre FoucaudChristophe MarguetAleksander EdelmanAlexandre HinzpeterPaola de CarliEmmanuelle GirodonIsabelle Sermet-GaudelusIwona Pranke
• Organismes : Institut Necker Enfants-Malades Institut Cochin Institut Necker Enfants-Malades Institut Necker Enfants-Malades Hospices Civils de Lyon Institut Necker Enfants-Malades Institut Necker Enfants-Malades Institut Necker Enfants-Malades Institut Necker Enfants-Malades Institut Necker Enfants-Malades Institut Necker Enfants-Malades Institut Necker Enfants-Malades Institut Necker Enfants-Malades
• Publié dans European Respiratory Journal le 23/10/2020

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Résumé : Background Around 20% of people with cystic fibrosis (pwCF) do not have access to the triple combination elexacaftor/tezacaftor/ivacaftor (ETI) in Europe because they do not carry the F508del allele on the CF transmembrane conductance regulator ( CFTR ) gene. Considering that pwCF carrying rare variants may benefit from ETI, including variants already validated by the US Food and Drug Administration (FDA), a compassionate use programme was launched in France. PwCF were invited to undergo a nasal brushing to investigate whether the pharmacological rescue of CFTR activity by ETI in human nasal epithelial cell (HNEC) cultures was predictive of the clinical response. Methods CFTR activity correction was studied by short-circuit current in HNEC cultures at basal state (dimethyl sulfoxide (DMSO)) and after ETI incubation and expressed as percentage of normal (wild-type (WT)) CFTR activity after sequential addition of forskolin and Inh-172 (Δ I ETI/DMSO %WT). Results 11 pwCF carried variants eligible for ETI according to the FDA label and 28 carried variants not listed by the FDA. ETI significantly increased CFTR activity of FDA-approved CFTR variants (I601F, G85E, S492F, M1101K, R347P, R74W;V201M;D1270N and H1085R). We point out ETI correction of non-FDA-approved variants, including N1303K, R334W, R1066C, Q552P and terminal splicing variants (4374+1G>A and 4096-3C>G). Δ I ETI/DMSO %WT was significantly correlated to change in percentage predicted forced expiratory volume in 1 s and sweat chloride concentration (p<0.0001 for both). G85E, R74W;V201M;D1270N, Q552P and M1101K were rescued more efficiently by other CFTR modulator combinations than ETI. Conclusions Primary nasal epithelial cells hold promise for expanding the prescription of CFTR modulators in pwCF carrying rare mutants. Additional variants should be discussed for ETI indication.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 10/10/2023
• Auteurs : Perrine VerdysJavier Rey BarrosoJoseph VermeilThibaut SanchezArnaud MétaisThomas MangeatE. BellardClaire BigotJean-Philippe GirardIsabelle Maridonneau-PariniChristel VérolletFrédéric LagarrigueAlba Diz-MuñozJulien HeuvinghMatthieu PielOlivia Du RoureVéronique Le CabecSébastien CarrénoRenaud Poincloux
• Organismes : Institut de pharmacologie et de biologie structurale Institut de pharmacologie et de biologie structurale Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris Institut de pharmacologie et de biologie structurale Institut de pharmacologie et de biologie structurale Centre de Biologie Intégrative Institut de pharmacologie et de biologie structurale Institut de pharmacologie et de biologie structurale Institut de pharmacologie et de biologie structurale Institut de pharmacologie et de biologie structurale Institut de pharmacologie et de biologie structurale Institut de pharmacologie et de biologie structurale European Molecular Biology Laboratory [Heidelberg] Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris Institut Pierre-Gilles de Gennes pour la Microfluidique Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris Institut de pharmacologie et de biologie structurale Institut de Recherche en Immunologie et en Cancérologie [UdeM-Montréal] Institut de pharmacologie et de biologie structurale

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Résumé : The cellular actin cortex provides crucial mechanical support and plays critical roles in numerous functions, including cell division and migration. The proteins of the ERM family, ezrin, radixin, and moesin, are central to these processes by linking the plasma membrane to the actin cytoskeleton. To investigate the individual contributions of these three proteins to leukocyte migration, we generated single and triple ERM knockout macrophages. Surprisingly, we found that even in the absence of ERMs, macrophages can still form the different actin structures promoting cell migration, such as filopodia, lamellipodia, podosomes, and ruffles. Furthermore we discovered that, unlike every other cell type previously investigated, the single or triple knockout of ERMs does not affect macrophage migration in a large diversity of contexts. Finally, we demonstrated that the loss of ERMs in macrophages does not affect the mechanics of their actin cortex. These findings challenge the notion that .

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Fichiers liés : P. Verdys et al. Biorxiv 2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 08/10/2023
• Auteurs : Mustapha MeftahCannelle ClavierAlain SarkissianAlain HauchecorneSlimane BekkiFranck LefèvrePatrick H. M. GalopeauPierre-Richard DahooAndrea PazmiñoAndré-Jean VieauChristophe DufourPierre MasoNicolas CaignardFrédéric FerreiraPierre GilbertOdile Hembise Fanton D’andonSandrine MathieuAntoine ManginCatherine BillardPhilippe Keckhut
• Organismes : STRATO - LATMOS Analytic and Computational Research, Inc. - Earth Sciences Laboratoire Atmosphères, Milieux, Observations Spatiales STRATO - LATMOS STRATO - LATMOS STRATO - LATMOS STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales STRATO - LATMOS STRATO - LATMOS Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Laboratoire Atmosphères, Milieux, Observations Spatiales Analytic and Computational Research, Inc. - Earth Sciences Analytic and Computational Research, Inc. - Earth Sciences Analytic and Computational Research, Inc. - Earth Sciences Laboratoire Atmosphères, Milieux, Observations Spatiales STRATO - LATMOS
• Publié dans Remote Sensing le 28/10/2020

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Résumé : Climate change is undeniably one of the most pressing and critical challenges facing humanity in the 21st century. In this context, monitoring the Earth’s Energy Imbalance (EEI) is fundamental in conjunction with greenhouse gases (GHGs) in order to comprehensively understand and address climate change. The French Uvsq-Sat NG pathfinder mission addresses this issue through the implementation of a Six-Unit CubeSat, which has dimensions of 111.3 × 36.6 × 38.8 cm in its unstowed configuration. Uvsq-Sat NG is a satellite mission spearheaded by the Laboratoire Atmosphères, Observations Spatiales (LATMOS), and supported by the International Satellite Program in Research and Education (INSPIRE). The launch of this mission is planned for 2025. One of the Uvsq-Sat NG objectives is to ensure the smooth continuity of the Earth Radiation Budget (ERB) initiated via the Uvsq-Sat and Inspire-Sat satellites. Uvsq-Sat NG seeks to achieve broadband ERB measurements using state-of-the-art yet straightforward technologies. Another goal of the Uvsq-Sat NG mission is to conduct precise and comprehensive monitoring of atmospheric gas concentrations (CO2 and CH4) on a global scale and to investigate its correlation with Earth’s Outgoing Longwave Radiation (OLR). Uvsq-Sat NG carries several payloads, including Earth Radiative Sensors (ERSs) for monitoring incoming solar radiation and outgoing terrestrial radiation. A Near-Infrared (NIR) Spectrometer is onboard to assess GHGs’ atmospheric concentrations through observations in the wavelength range of 1200 to 2000 nm. Uvsq-Sat NG also includes a high-definition camera (NanoCam) designed to capture images of the Earth in the visible range. The NanoCam will facilitate data post-processing acquired via the spectrometer by ensuring accurate geolocation of the observed scenes. It will also offer the capability of observing the Earth’s limb, thus providing the opportunity to roughly estimate the vertical temperature profile of the atmosphere. We present here the scientific objectives of the Uvsq-Sat NG mission, along with a comprehensive overview of the CubeSat platform’s concepts and payload properties as well as the mission’s current status. Furthermore, we also describe a method for the retrieval of atmospheric gas columns (CO2, CH4, O2, H2O) from the Uvsq-Sat NG NIR Spectrometer data. The retrieval is based on spectra simulated for a range of environmental conditions (surface pressure, surface reflectance, vertical temperature profile, mixing ratios of primary gases, water vapor, other trace gases, cloud and aerosol optical depth distributions) as well as spectrometer characteristics (Signal-to-Noise Ratio (SNR) and spectral resolution from 1 to 6 nm).

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Fichiers liés : remotesensing-15-04876-v2.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/10/2023
• Auteurs : Yves Tranquille-MarquesJean-Philippe AiriauPierre BaudonIrwin IssuryAlain Mugnier
• Organismes : Centre d'études scientifiques et techniques d'Aquitaine (CESTA-CEA) Centre d'études scientifiques et techniques d'Aquitaine (CESTA-CEA) Centre d'études scientifiques et techniques d'Aquitaine (CESTA-CEA) Centre d'études scientifiques et techniques d'Aquitaine (CESTA-CEA) Centre d'études scientifiques et techniques d'Aquitaine (CESTA-CEA)

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Résumé : The LMJ*, a 176-beam laser facility developed by the French Nuclear Science directorate CEA, is located at the CEA** CESTA site near Bordeaux. The LMJ facility is part of the French Simulation Program. It is designed to deliver about 1.4 MJ of energy on targets, for high energy density physics experiments, including fusion experiments. Since 2022, the LMJ facility aims at carrying out experiments with 12 bundles of 8 laser beams and 12 target diagnostics. In order to achieve daily shots including all the preparatory steps, the LMJ performs night activities from now on and the presence of technical operators is not required. These sequences work on vacuum windows inspection and beam alignment. They take into account all the prerequisites for their good performances and are scheduled automatically one after the other. They deal with material security and unexpected equipment alarms. They endeavour to required tasks success and give a detailed report of the night events to the shot director. This paper gives a presentation of the two sequences with solutions in order to answer the technical specifications and the last enhancements.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 06/10/2023
• Auteurs : Ibrahim FayadPhilippe CiaisMartin SchwartzJean-Pierre WigneronNicolas BaghdadiAurélien de TruchisAlexandre d'AspremontFrederic FrappartSassan SaatchiAgnes Pellissier-TanonHassan Bazzi
• Organismes : Kayrros Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Contrôles des cycles biogéochimiques terrestres Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Contrôles des cycles biogéochimiques terrestres Interactions Sol Plante Atmosphère Territoires, Environnement, Télédétection et Information Spatiale Kayrros Laboratoire d'informatique de l'école normale supérieure Centre National de la Recherche Scientifique Statistical Machine Learning and Parsimony Université Paris Sciences et Lettres Interactions Sol Plante Atmosphère California Institute of Technology Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640) Atos

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Résumé : Accurate and timely monitoring of forest canopy heights is critical for assessing forest dynamics, biodiversity, carbon sequestration as well as forest degradation and deforestation. Recent advances in deep learning techniques, coupled with the vast amount of spaceborne remote sensing data offer an unprecedented opportunity to map canopy height at high spatial and temporal resolutions. Current techniques for wall-to-wall canopy height mapping correlate remotely sensed 2D information from optical and radar sensors to the vertical structure of trees using LiDAR measurements. While studies using deep learning algorithms have shown promising performances for the accurate mapping of canopy heights, they have limitations due to the type of architectures and loss functions employed. Moreover, mapping canopy heights over tropical forests remains poorly studied, and the accurate height estimation of tall canopies is a challenge due to signal saturation from optical and radar sensors, persistent cloud covers and sometimes the limited penetration capabilities of LiDARs. Here, we map heights at 10 m resolution across the diverse landscape of Ghana with a new vision transformer (ViT) model optimized concurrently with a classification (discrete) and a regression (continuous) loss function. This model achieves better accuracy than previously used convolutional based approaches (ConvNets) optimized with only a continuous loss function. The ViT model results show that our proposed discrete/continuous loss significantly increases the sensitivity for very tall trees (i.e., > 35m), for which other approaches show saturation effects. The height maps generated by the ViT also have better ground sampling distance and better sensitivity to sparse vegetation in comparison to a convolutional model. Our ViT model has a RMSE of 3.12m in comparison to a reference dataset while the ConvNet model has a RMSE of 4.3m.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 06/10/2023
• Auteurs : Carine CalastrencChristine RenduNicolas PoirierFrançois BaleuxPierre CampmajoNicolas DobigeonNicolas MelladoClaire Sicre-MaraisJordi IngladaMarie-Claude BalMagalie PhillippeMuriel LlubesLuc Lapierre
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés France, Amériques, Espagne, Sociétés, Pouvoirs, Acteurs France, Amériques, Espagne, Sociétés, Pouvoirs, Acteurs Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Signal et Communications Institut universitaire de France Institut National Polytechnique (Toulouse) Centre National de la Recherche Scientifique Structural Models and Tools in Computer Graphics Centre d'études spatiales de la biosphère Centre National d'Études Spatiales [Toulouse] Centre d'études spatiales de la biosphère Géographie de l'environnement Géographie de l'environnement Géosciences Environnement Toulouse Société Française de Photogrammétrie et Télédétection

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Fichiers liés : Toulouse_2023_TAHMM.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 05/10/2023
• Auteurs : Yavuz DegerliFabrice GuillouxTomasz HemperekJean-Pierre MeyerPhilippe Schwemling
• Organismes : Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers

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Résumé : MiniCACTUS is a monolithic sensor prototype optimised for timing measurement of charged particles. It has been designed in a standard 150 nm CMOS process without dedicated amplification layer. It is intended as a demonstrator chip for future large scale timing detectors, like upgrades of timing detectors at LHC, or future high energy physics detector projects. The sensor features an active array of 2 x 4 diodes, analog and digital Front-Ends (FEs), a slow control interface, and bias circuitry programmable through internal DACs. The sensing element is a deep n-well/p-substrate diode. Thanks to the optimized guard-rings surrounding the whole chip, it is possible to apply safely more than 450 V on the high-resistivity substrate allowing fast charge collection. The baseline pixel dimensions are 1.0 mm x 1.0 mm and 0.5 mm x 1.0 mm. The analog FEs and the discriminators for each pixel are implemented outside the pixel, at the column level. The power consumption is approximately 300 mW/cm$\mathbf {^2}$, which is compatible with cooling infrastructure available at LHC experiments, and making integration of this concept viable in future high energy physics experiments. After fabrication, the sensors have been thinned to 100 $\mu$m, 200 $\mu$m and 300 $\mu$m total thickness and then post-processed for backside biasing. The time resolution of several sensors with different thicknesses has been measured in 3 test-beam campaigns using high energy muons (Minimum Ionizing Particles) at CERN SPS in 2021 and 2022. A resolution of 65.3 ps has been measured with on-chip FE and discriminator. This paper will focus on the results of these test-beam campaigns.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/10/2023
• Auteurs : Philippe GouézinVincent ArdJean GuilaineEmmanuel Mens
• Organismes : Centre de Recherche en Archéologie, Archéosciences, Histoire Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Collège de France Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Académie des inscriptions et belles-lettres Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/10/2023
• Auteurs : Pablo MarticorenaMarylise OnfrayEmmanuel MensFrancis BichotPhilippe GardesPhilippe Gouézin
• Organismes : Ausonius-Institut de recherche sur l'Antiquité et le Moyen âge Institut national de recherches archéologiques préventives Littoral, Environnement, Télédétection, Géomatique UMR 6554 Institut national de recherches archéologiques préventives Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Université de Rennes

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/10/2023
• Auteurs : Jean CollinetPascale ChevillotMarion GasnierCatherine RigeadeIsabelle Rodet-BelarbiSargiano Jean-Philippe
• Organismes : Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Laboratoire d'Archéologie Médiévale et Moderne en Méditerranée Institut national de recherches archéologiques préventives Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Institut national de recherches archéologiques préventives Archéologie des Sociétés Méditerranéennes

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