Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 01/01/2026
• Auteurs : Martin SchwartzFajwel FogelNikola BesicDamien RobertLouis GeistJean-Pierre RenaudJean-Matthieu MonnetClemens MosigCédric VégaAlexandre d'AspremontLoic LandrieuPhilippe Ciais
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] CEA- Saclay Université Paris-Saclay Département d'informatique - ENS-PSL Université Gustave Eiffel IGN-France International Laboratoire d'Inventaire Forestier Ecole Nationale Supérieure de Géologie Universität Zürich [Zürich] = University of Zurich École nationale des ponts et chaussées Laboratoire d'Informatique Gaspard-Monge Université Gustave Eiffel Université de Lorraine Université Gustave Eiffel IGN-France International Laboratoire d'Inventaire Forestier Recherche, développement et innovation Laboratoire des EcoSystèmes et des Sociétés en Montagne Université Grenoble Alpes INRAE Transfert Faculty of Physics and Earth Sciences, Leipzig Institute for Meteorology, University of Leipzig Université Gustave Eiffel IGN-France International Ecole Nationale Supérieure de Géologie Laboratoire d'Inventaire Forestier Université de Lorraine Laboratoire d'informatique de l'école normale supérieure Centre National de la Recherche Scientifique Université Paris Sciences et Lettres École nationale des ponts et chaussées Laboratoire d'Informatique Gaspard-Monge Université Gustave Eiffel Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Contrôles des cycles biogéochimiques terrestres

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Résumé : The recent decline of the European forest carbon sink highlights the need for spatially explicit and frequently updated forest monitoring tools. Yet, existing satellite-based disturbance products remain too coarse to detect changes at the scale of individual trees, typically below 100 m². Here, we introduce FORMSpoT (Forest Mapping with SPOT Time series), a decade-long (2014-2024) nationwide mapping of forest canopy height at 1.5 m resolution, together with annual disturbance polygons (FORMSpoT-Δ) covering mainland France. Canopy heights were derived from annual SPOT-6/7 composites using a hierarchical transformer model (PVTv2) trained on high-resolution airborne laser scanning (ALS) data. To enable robust change detection across heterogeneous acquisitions, we developed a dedicated post-processing pipeline combining co-registration and spatio-temporal total variation denoising. Validation against ALS revisits across 19 sites and 5,087 National Forest Inventory plots shows that FORMSpoT-Δ substantially outperforms existing disturbance products. In mountainous forests, where disturbances are small and spatially fragmented, FORMSpoT-Δ achieves an F1-score of 0.44, representing an order of magnitude higher than existing benchmarks. By enabling tree-level monitoring of forest dynamics at national scale, FORMSpoT-Δ provides a unique tool to analyze management practices, detect early signals of forest decline, and better quantify carbon losses from subtle disturbances such as thinning or selective logging. These results underscore the critical importance of sustaining very high-resolution satellite missions like SPOT and open-data initiatives such as DINAMIS for monitoring forests under climate change.

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Fichiers liés : 2512.17021v1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Nicolas BarbierPierre PlotonHadrien TuletGaëlle ViennoisHugo LeblancBenoit BurbanMaxime Réjou-MéchainPhilippe VerleyJames BallDenis FeurerGrégoire Vincent
• Organismes : Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Université de Yaoundé I Ecologie des forêts de Guyane Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Botanique et Modélisation de l'Architecture des Plantes et des Végétations Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème Botanique et Modélisation de l'Architecture des Plantes et des Végétations
• Publié dans ISPRS Open Journal of Photogrammetry and Remote Sensing le 08/04/2024

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Résumé : This study benefited from an "Investissement d'Avenir" grant managed by the Agence Nationale de la Recherche (CEBA, ref. ANR-10-LABX-25-01), via project PHENOBS. We also acknowledge the support of the UE Biodiversa+ BiodivMon program (Project Coforfunc). We are thankful to Ilona Clocher, Jean-Louis Smock, Jean-Yves Goret, Florian Jeanne and Julien Engel for their help with drone data acquisition and/or processing. Access to the Paracou site and infrastructure (https://paracou.cirad.fr) was granted by CIRAD/Ecofog, and we thank Géraldine Derroire and all Phenobs project participants. We are grateful to Raphaël Pélissier for helping in the initial shaping of the Phenobs project and for his continued support.

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Fichiers liés : 2025.06.27.661894.full_bioarXiv.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Bénédicte LelièvreCharlotte GodonPierre LegrasJeremie RiouDavid TernantJean-Philippe Bouchara
• Organismes : SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Département de Pharmacologie-Toxicologie [CHU Angers] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Micro et Nanomédecines Translationnelles Membrane Signalling and Inflammation in reperfusion Injuries Centre Hospitalier Régional Universitaire de Tours SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques
• Publié dans Biomedicine and Pharmacotherapy le 28/10/2020

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Résumé : Background: Posaconazole, a broad spectrum antifungal, may be used in salvage therapy for cerebral infections caused by Scedosporium species. In this study, its pharmacokinetics was investigated in a rat model of scedosporiosis to evaluate the effect of the infection on cerebral diffusion. Methods: Posaconazole was administered to two groups of rats randomized according to the infection status. Drug levels in plasma, cerebrospinal fluid, and brain tissue were measured up to 168 h after administration, and data were analyzed using a non-compartmental approach. In addition, interleukins (IL) (IL-1β and IL-10) were quantified by ELISA, and cerebral expression of genes encoding some efflux pumps was assessed by reverse transcription-quantitative PCR. Results: Cerebral diffusion of posaconazole and, to a lesser extent, cerebrospinal fluid exposure were significantly affected by infection. A ten-fold increase in the area under the curve and a delayed time (Tmax) to reach the maximum concentration (Cmax) were observed in the brain, along with a time lag to reach Cmax and Tmax between plasma and the brain. Infection was associated with changes in plasma pharmacokinetics, particularly at late sampling times. Conclusions: These findings suggest increased permeability of the blood-brain-barrier, possibly related to changes in IL or gene expression levels in the brain. Infection and the resulting inflammation should therefore be considered for therapeutic drug monitoring, especially in cases of cerebral infection.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Eric VandermolenPhilippe FerrandisFrédéric AllibertEmmanuel AugendreMassinissa NabetMartin RackJean-Pierre RaskinM. Cassé
• Organismes : Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information SOITEC Semi-conducteurs à large bande interdite SOITEC Département Composants Silicium Institute of Information and Communication Technologies, Electronics and Applied Mathematics Institute of Information and Communication Technologies, Electronics and Applied Mathematics Institute of Information and Communication Technologies, Electronics and Applied Mathematics Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information
• Publié dans Solid-State Electronics le 22/10/2020

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Résumé : In this work, radio-frequency and traps properties of unintentionally doped polycrystalline silicon (polySi) deposited by low pressure chemical vapor deposition (LPCVD) on high resistivity silicon (HR-Si) substrate are characterized. Both volume (i.e. inside polySi) and interface traps (i.e. near polySi/HR-Si) are detected by photo-induced current transient spectroscopy (PICTS). A thermal budget of 900 ◦C during 2 h is sufficient to observe trap densities reduction near the polySi/HR-Si interface, affecting the RF performance of the fabricated substrates.

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Fichiers liés : Traps-and-RF-Characterization-of-Polysilicon-Layer_draft_no-T1100_final.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Thibaut DevilleSelim CheaibiM. LlariWei WeiAnaïs GaroJean-Philippe LepretreP. J. ArnouxCatherine Masson
• Organismes : Laboratoire de Biomécanique Appliquée Laboratoire de Biomécanique Appliquée Laboratoire de Biologie Appliquée
• Publié dans Accident Analysis & Prevention le 24/10/2020

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Résumé :

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Margherita FabbriAymeric LanoreNathalie BertilleJean-Christophe CorvolOlivier J. RascolPhilippe RémyLuc DefebvreChloé LaurencinJean-Philippe AzulaySolène FrismandPhilppe DamierCaroline Giordana ReutherFazia Mélissa TirClaire ThiriezGwendoline DupontJean-Luc HouetoChristian GenyGiovanni CastelnovoAnne Doe de MaindrevilleSophie DrapierDavid MaltêteSolène AnsquerMatthieu AnheimFlorence TubachChristine Brefel-Courbon
• Organismes : Centre d'investigation clinique de Toulouse Toulouse NeuroImaging Center Institut du Cerveau = Paris Brain Institute Centre de pharmacoépidémiologie AP-HP Centre de pharmacoépidémiologie AP-HP Centre d'investigation clinique de Toulouse Centre d’Excellence en Maladies Neurodégénératives IMRB - "NeuroPsychologie Interventionnelle" [Créteil] Lille Neurosciences & Cognition - U 1172 Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [CHRU Nancy] Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Service de Neurologie [CHU Nice] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Service de neurologie [CHU de Poitiers] Service de Neurologie [Strasbourg] Service de neurochirurgie [CHU Dijon] Epidémiologie des Maladies Chroniques en zone tropicale Service de Neurologie [CHU Limoges] CHU Montpellier = Montpellier University Hospital Service de Neurologie [CHU Nimes] Service de neurologie [Reims] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Service de neurologie [Rouen] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Service de Neurologie [Strasbourg] Institut Pierre Louis d'Epidémiologie et de Santé Publique Pharmacoépidémiologie et évaluation des soins [iPLesp] Centre de pharmacoépidémiologie AP-HP Toulouse NeuroImaging Center Centre d'investigation clinique de Toulouse
• Publié dans Parkinsonism & Related Disorders le 02/11/2020

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Résumé : Background: Postural abnormalities (PA) and motor complications (MCs, including motor fluctuations - MFs- and levodopa-induced dyskinesia - LIDs) are hallmark of Parkinson's disease (PD) progression, yet their relationship remains poorly understood. Objective: To investigate the association between PA and MCs, motor symptoms, and non-motor symptoms (NMS) in patients with PD, and to assess whether PA influences the development of MCs over time. Methods: Data of the prospective NS-Park cohort (27 French PD Expert Centers) were analysed. PA was defined by a score ≥2 on item 3.13 of the MDS-UPDRS-III. Associations between PA and MCs, as well as with other motor symptoms and NMS, were assessed using logistic regression models. We used interval censoring survival models to assess the associations between PA at inclusion and the incidence of MCs. Analyses were adjusted for sex, age, disease duration, dopaminergic dose, and disease severity. Results: Among 13,037 included PD patients (58.7 % male, median age at diagnosis 61 years), 724 (5.6 %) presented with PA. Patients with PA had longer disease duration, higher disease severity, and higher dopaminergic treatment. PA exhibited a higher prevalence of troublesome MFs (OR: 5.96; 95 % CI: 4.25-8.32) and LIDs (OR: 2.81; 95 % CI: 1.79-4.30), while associations with milder MCs were inconsistent. However, PA was not significantly associated with the development of MCs during follow-up. Conclusions: PA are associated with more frequent severe MCs, and a higher burden of motor and NMS, making patient care particularly challenging.

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Fichiers liés : Fabbri et al. - 2025 - Motor complications and postural abnormalities interplay in Parkinson’s disease_removed.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Antoine GavoilleMikaïl NourredineFabien RollotRomain CaseyGuillaume MatheyAnne KerbratJonathan CironJérôme de SèzeBruno StankoffElisabeth MaillartAurélie RuetPierre M. LabaugeArnaud KwiatkowskiHélène ZéphirCaroline PapeixGilles-Louis DeferChristine Lebrun-FrenayThibault MoreauDavid-Axel LaplaudEric BergerPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagySolène MoulinJean-Philippe CamdessanchéInès DoghriMariana SarovKarolina HankiewiczCorinne PottierAmélie dos SantosÉric ManchonMaia TchikviladzeMuriel RabilloudFabien SubtilSandra Vukusic
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Hospices Civils de Lyon Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique [Nancy] Service de neurologie [Rennes] Neuroimagerie: méthodes et applications Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] CIC Strasbourg Service de Neurologie [Strasbourg] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Hôpital Saint Vincent de Paul [Lille] Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université Paris Cité Service de Neurologie [CHU Caen] Normandie Université UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Service de Neurologie [CHU Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Service de Neurologie [CHRU Besançon] Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Hôpital Henri Mondor Service de Neurologie [CHU Limoges] Service de neurologie [Reims] Service de Neurologie [CHU de Saint-Étienne] Centre Hospitalier Régional Universitaire de Tours Service de neurologie [Le Kremlin Bicêtre] Centre Hospitalier de Saint-Denis [Ile-de-France] hôpital NOVO Service de neurologie [CHU de Poitiers] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre Hospitalier de Gonesse Hôpital Foch [Suresnes] Alte University [Tbilissi] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Hospices Civils de Lyon Fondation Eugène Devic EDMUS
• Publié dans Journal of Neurology, Neurosurgery and Psychiatry le 25/10/2020

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Résumé : Background: Target trial emulation (TTE) offers a formal framework for causal inference using observational data, but its validity must be evaluated in each research domain by replicating randomised clinical trials (RCTs). We aimed to replicate eight RCTs evaluating the efficacy of disease-modifying therapies (DMTs) in multiple sclerosis (MS) using French registry data. Methods: This multicentre, retrospective, observational study was conducted using data extracted in December 2023 from the Observatoire Français de la Sclérose en Plaques (OFSEP) database. For each emulated trial, patients were included when they initiated one of the DMT evaluated in the corresponding RCT and met its inclusion criteria. Clinical outcomes were the annualised relapse rate and 3-month confirmed Expanded Disability Status Scale progression. Radiological outcomes were new/enlarged T2-lesions and new gadolinium-enhanced T1-lesions on a brain MRI. A targeted maximum likelihood estimator was used to estimate the treatment effect adjusted for confounding factors between groups and corrected for censoring and missing outcome assessment. Results: 14 111 patients were included in eight emulated trials: ASSESS (fingolimod vs glatiramer acetate), BEYOND (interferon beta vs glatiramer acetate), CONFIRM (dimethyl fumarate (DMF) vs glatiramer acetate), OPERA (ocrelizumab vs interferon beta), REGARD (interferon beta vs glatiramer acetate), RIFUND-MS (rituximab vs DMF), TENERE (teriflunomide vs interferon beta) and TRANSFORMS (fingolimod vs interferon beta). Treatment effects estimated in emulated trials were concordant with RCT findings in seven of eight trials for relapse rate, and in all six trials assessing disability progression. Radiological outcomes were more challenging to replicate; concordance was achieved in three of five trials for new T2-lesions, and one of four trials for new gadolinium-enhanced T1-lesions. Conclusion: The combined use of a TTE methodology and high-quality registry data is a valid tool to evaluate treatment effectiveness in MS.

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Fichiers liés : Gavoille et al 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : M. Desnos-OllivierAlexandre AlanioMaud Gits-MuselliKarine Boukris-SitbonAgathe BerthoAude Sturny-LeclèreEmilie GuemasPhilippe PoirierChristine BonnalMarie-Elisabeth BougnouxSophie BrunTaieb ChouakiNicole Desbois-NogardElisabeth ChachatyFlorence PersatMarc PihetAndré PaugamFrançoise BotterelMagalie DemarLoïc FavennecOlivier LortholaryFlorent MorioFrederic GabrielArnaud FekkarJean-Pierre GangneuxCaroline MahincValérie Letscher-BruLaurence MillonFrédéric DalleJulie BonhommeMuriel NicolasBoualem SendidMilène SassoLaure CourtellemontAnne-Laure RouxEstelle CateauJuliette GuitardEdith MazarsFanny Lanternier
• Organismes : Institut Pasteur [Paris] Institut Pasteur [Paris] Hopital Saint-Louis [AP-HP] Hôpital Robert Debré Infection, Anti-microbiens, Modélisation, Evolution Institut Pasteur [Paris] Institut Pasteur [Paris] Institut Pasteur [Paris] Centre National de la Recherche Scientifique CHU Clermont-Ferrand Université Blaise Pascal - Clermont-Ferrand 2 AP-HP - Hôpital Bichat - Claude Bernard [Paris] Hôpital Necker - Enfants Malades [AP-HP] Hôpital Avicenne [AP-HP] CHU Amiens-Picardie Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Département de biologie et pathologie médicales [Gustave Roussy] Hospices Civils de Lyon SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Groupe d'Étude des Interactions Hôte-Pathogène Maternité Port-Royal [CHU Cochin] Université Paris-Est Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] Hôpital Charles Nicolle [Rouen] Institut Pasteur [Paris] Hôpital Necker - Enfants Malades [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Bordeaux Centre d'Immunologie et des Maladies Infectieuses Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpitaux Universitaires de Strasbourg Centre Hospitalier Régional Universitaire de Besançon Laboratoire Chrono-environnement (UMR 6249) Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Hôpital Côte de Nacre [CHU Caen] CHU Pointe-à-Pitre / Abymes [Guadeloupe] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Nîmes Université de Montpellier Centre Hospitalier Universitaire d'Orléans Assistance publique - Hôpitaux de Paris (AP-HP) Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CHU Saint-Antoine [AP-HP] Centre Hospitalier de Valenciennes Institut Pasteur [Paris] Hôpital Necker - Enfants Malades [AP-HP]
• Publié dans Emerging Infectious Diseases le 27/10/2020

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Résumé : Fungi in the family Trichosporonaceae are rarely involved in invasive disease but are frequently associated with colonization or respiratory allergic infection. Trichosporonaceae exhibit intrinsic resistance to echinocandin antimicrobial drugs, posing challenges for treatment and contributing to high mortality rates. We complied a nationwide analysis of 112 cases of invasive disease caused by Trichosporon spp. and related fungi, diagnosed in France over 20 years, that combined clinical data, susceptibility profiles, and molecular identification. We identified 12 species; T. asahii was the most common species recovered, and the new species T. austroamericanum was next. Comparison of clinical data highlighted species and genotypic differences, such as a much higher proportion of children infected by T. asahii and major differences in antimicrobial drug susceptibility. Correct identification is not only of epidemiologic interest but also necessary for patient management because of the varying clinical and microbiological characteristics found in different species.

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Fichiers liés : 25-0504-combined.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Anouchka ModestoSophie GibertCaroline DelmasDavid TougeronAmaury PaumierAlexandre TaillezSamuel Le SourdDelphine Argo LeignelPhilippe RonchinAriane Darut JouveVéronique VendrelyOlivier RiouJérôme Martin-BabauThomas LeroyLaurent QuéroNaima HanounPierre CordelierVeronica PezzellaJean-Pierre DelordRosine GuimbaudElizabeth Cohen-Jonathan MoyalCatherine Seva
• Organismes : Oncopole Claudius Regaud Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse Oncopole Claudius Regaud Institut Universitaire du Cancer de Toulouse - Oncopole Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Centre Eugène Marquis Groupe Hospitalier Bretagne Sud Centre Azuréen de Cancérologie [Mougins, France] Institut de Cancérologie de Bourgogne Centre Hospitalier Universitaire de Bordeaux UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle Centre Armoricain de Radiothérapie, d'Imagerie médicale et d'Oncologie [Plérin, Saint-Brieuc] Centre Hospitalier de Valenciennes Hopital Saint-Louis [AP-HP] Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse UNICANCER Oncopole Claudius Regaud Institut Universitaire du Cancer de Toulouse - Oncopole Département Oncologie médicale digestive [CHU Toulouse] Centre de Recherches en Cancérologie de Toulouse Oncopole Claudius Regaud Institut Universitaire du Cancer de Toulouse - Oncopole Centre de Recherches en Cancérologie de Toulouse
• Publié dans International Journal of Cancer le 30/10/2020

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Résumé : Locally advanced esophageal carcinoma remains of poor prognosis correlated with tumor stage. Albeit liquid biopsy approach offers promising results to monitor high‐risk patients in various solid tumors, the lack of specific mutation in esophageal tumor, limits the detection of circulating tumor DNA (ctDNA) with high sensitivity using sequencing‐based methods. In this study, we employed a highly sensitive technology of fragmentome assay, previously validated to measure concentration and size distribution of cell‐free DNA (cfDNA), to analyze plasma samples from 77 patients with esophageal carcinoma, compared to 15 healthy controls. Total cfDNA concentration was significantly higher in patients than in healthy donors (15.03 ± 1.37 vs. 5.87 ± 0.85 pg/μL, p < .0001). The difference remained significant regardless of tumor histology, location, stage, or nodal involvement and was independent from age or gender. Additionally, we observed a significant reduction in patients fragment length compared to healthy donors. The area under curve from receiver operating characteristic (ROC) of total cfDNA concentration in patients versus healthy donors was 0.86 ( p ‐value <.0001). The threshold of 7.5 pg/μL yielded a sensitivity of 81% and a specificity of 80%. This prospective study demonstrated that blood samples from patients exhibit a greater global concentration of smaller fragments compared to healthy controls. These findings support further longitudinal evaluation to determine the predictive and prognostic value of cfDNA in locally advanced unresectable esophageal carcinoma.

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Fichiers liés : Modesto_2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2026
• Auteurs : Miloud CherbiPhilippe MauryPierre GroussinMathilde Hamel-BougaultFrancis BessièreMatteo PozziFabrice ExtramianaCharles GuenanciaAudrey SagnardSandro NinniCéline GoeminePascal DefayeAude BoignardBaptiste MailleVlad GariboldiPierre BaudinaudAnne-Céline MartinLaure Champ-RigotKatrien BlanchartJean-Marc SellalChristian de ChillouLaurence Jesel-MorelMichel KindoCorentin ChaumontFrédéric AnselmeMarine ArnaudErwan FlécherLéa BenabouMaxime FaureShaida VarnousEstelle GandjbakhchPaul GautierRedwane RakzaKarim BenaliRaphaël P MartinsClément Delmas
• Organismes : Université Toulouse III - Paul Sabatier Centre Hospitalier Universitaire de Toulouse Université Toulouse III - Paul Sabatier Centre Hospitalier Universitaire de Toulouse Centre d'Investigation Clinique [Rennes] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Hôpital Louis Pradel [CHU - HCL] Hôpital Louis Pradel [CHU - HCL] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Hôpital de la Timone [CHU - APHM] Hôpital de la Timone [CHU - APHM] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire [Strasbourg] Centre Hospitalier Universitaire [Strasbourg] CHU Rouen CHU Rouen Hôpital Haut-Lévêque [CHU Bordeaux] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Hôpital Haut-Lévêque [CHU Bordeaux] Hôpital Haut-Lévêque [CHU Bordeaux] CHU Pitié-Salpêtrière [AP-HP] Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] CHU Pitié-Salpêtrière [AP-HP] Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] Université Toulouse III - Paul Sabatier Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Hôpital Haut-Lévêque [CHU Bordeaux] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Université Toulouse III - Paul Sabatier
• Publié dans Jhlt Open le 05/01/2026

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Résumé : Background Heart transplantation (HTx) has been suggested for refractory electrical storm (ES). Data regarding the outcomes of these patients are scarce. Objective To compare the prognosis of refractory ES patients listed for urgent HTx, with and without transplantation. Methods Patients registered on urgent HTx waiting list for refractory ES were retrospectively included in 13 French centers between 2010-2022. The primary endpoint was in-hospital all-cause mortality. Results Eighty-five patients were included (85.9% men; 56.0 [48.0–61.0] years old; 55.1% with dilated cardiomyopathy), among whom 45 (52.9%) ultimately underwent HTx during index hospitalization. In the overall cohort, 89.3% of patients received amiodarone, 64.3% beta-blockers, 45.9% required deep sedation, 5.9% underwent stellate ganglion block, and 41.2% received mechanical circulatory support. Catheter ablation was less frequently performed in the transplanted group (20.0% vs 57.5%, p < 0.01). No difference was found for in-hospital mortality between transplanted and non-transplanted patients (28.9% vs 35.0%, HR 0.72 [0.34-1.53], p=0.0.39). After 1-year follow-up, 14 patients (16.5%) of the non-transplanted group eventually underwent HTx, with 4 of them dying subsequently. Five patients (5.9%) were removed from HTx waiting list due to functional improvement. Conversely, 14 transplanted patients (16.5%) died. Conclusion Refractory ES carries a high in-hospital mortality rate, affecting one-third of patients. Overall, 69.4% of patients listed for urgent HTx underwent transplantation, including 52.9% during index hospitalization and 16.5% within the year post-discharge, highlighting the need to optimize selection criteria and implement a comprehensive treatment that sometimes allows overcoming the acute phase, enabling HTx under more stable conditions.

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Fichiers liés : 1-s2.0-S2950133426000509-main.pdf

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