Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2023
• Auteurs : Edith BorcomanAna LalanneJean-Pierre DelordPhilippe Alexandre CassierFrédéric RollandSébastien SalasJean-Marc LimacherOlivier CapitainOlivier LantzChristina EkwegbaraEmmanuelle JeannotJoanna CyrtaCarine Tran-PerennouZahra Castel-AjgalGrégoire MarretEliane PiaggioMaud BrandelyAnnette TavernaroHakim MakhloufiKaidre BendjamaChristophe Le Tourneau
• Organismes : Institut Curie [Paris] Institut Curie [Paris] CIC1428 IGR-CURIE Institut Universitaire du Cancer de Toulouse - Oncopole Oncopole Claudius Regaud Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] CRLCC René Gauducheau Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique Hôpital pasteur [Colmar] Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut Curie [Paris] Immunité et cancer Institut Curie [Paris] Institut Curie [Paris] Université Paris Descartes - Faculté de Médecine Immunité et cancer Transgene SA [Illkirch] Transgene SA [Illkirch]
• Publié dans European Journal of Cancer le 22/10/2020

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Fichiers liés : S0959804923003337.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2023
• Auteurs : Romain SonnevilleMikaël MazighiMagalie ColletEtienne GayatVincent DegosJacques DuranteauCharles GrégoireTarek SharsharGiulia NaimDavid CortierPaul-Henri JostArnaud FoucrierFrançois BagateEtienne de MontmollinGregory PapinEric MagalhaesBertrand GuidetOmar Ben Hadj SalemSarah BenghanemLoic Le GuennecEric DelpierreStéphane LegrielBruno MégarbaneKarim ToumertMarc TranGuillaume GeriMehran MonchiEric BodiguelEric MariotteAlexandre DemouleJonathan ZarkaJean-Luc DiehlDamien RouxEric BarréSébastien TanakaDavid OsmanPierre PasquierFariza LamaraIsabelle CrassardPerrine BoursinStéphane RucklyQuentin StaiqulyJean-François TimsitFrance WoimantTiare AderHélène BoutDamien BressonAlain CombesAnne ChrismentSophie CrozierDaniel da SilvaMaxens DecaveleMartin DresFrédéric FaugerasMarie-Céline FournierTobias GaussCoralie GernezDominique HurelMatthieu JammeLaurence JosseIgor JurcisinLionel KerhuelCatherine LamyAymeric LancelotBertrand LapergueChristophe LencludMathilde LermuzeauxIsabelle MalissinAlain MaldjianNathalie MarinJérôme MartinThibault MartinezArmand Mekontso DessapHervé OutinClaire PichereauMatthieu PissotKeyvan RazaziDanielle ReuterChristian RichardCaroline SchimpfJérôme ServanLaurie-Anne ThionWidad TrakiPhilippe VasselBernard ViguéDaniel Zafimahazo
• Organismes : Infection, Anti-microbiens, Modélisation, Evolution Service de neurologie [Hôpital Fondation Adolphe de Rothschild] Service de Neuroradiologie [CHU Lariboisière] Marqueurs cardiovasculaires en situation de stress Hôpital Lariboisière-Fernand-Widal [APHP] Service d'Anesthésie-Réanimation [AP-HP Hôpitaux Saint-Louis Lariboisière] Institut du Cerveau = Paris Brain Institute Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Radiologie et Imagerie Médicale Institut de psychiatrie et neurosciences de Paris Optimisation thérapeutique en Neuropsychopharmacologie Hôpital Beaujon [AP-HP] Institut Mondor de Recherche Biomédicale Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) Infection, Anti-microbiens, Modélisation, Evolution AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution AP-HP - Hôpital Bichat - Claude Bernard [Paris] Centre hospitalier de Saint-Brieuc [Hôpital Yves Le Foll] CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Hôpital Cochin [AP-HP] Institut de psychiatrie et neurosciences de Paris Hôpital Cochin [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université Centre Hospitalier Universitaire [CHU Grenoble] Université Grenoble Alpes
• Publié dans Stroke le 31/10/2020

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Résumé : BACKGROUND: Long-term outcomes of patients with severe stroke remain poorly documented. We aimed to characterize one-year outcomes of patients with stroke requiring mechanical ventilation in the intensive care unit (ICU). METHODS: We conducted a prospective multicenter cohort study in 33 ICUs in France (2017–2019) on patients with consecutive strokes requiring mechanical ventilation for at least 24 hours. Outcomes were collected via telephone interviews by an independent research assistant. The primary end point was poor functional outcome, defined by a modified Rankin Scale score of 4 to 6 at 1 year. Multivariable mixed models investigated variables associated with the primary end point. Secondary end points included quality of life, activities of daily living, and anxiety and depression in 1-year survivors. RESULTS: Among the 364 patients included, 244 patients (66.5% [95% CI, 61.7%–71.3%]) had a poor functional outcome, including 190 deaths (52.2%). After adjustment for non-neurological organ failure, age ≥70 years (odds ratio [OR], 2.38 [95% CI, 1.26–4.49]), Charlson comorbidity index ≥2 (OR, 2.01 [95% CI, 1.16–3.49]), a score on the Glasgow Coma Scale <8 at ICU admission (OR, 3.43 [95% CI, 1.98–5.96]), stroke subtype (intracerebral hemorrhage: OR, 2.44 [95% CI, 1.29–4.63] versus ischemic stroke: OR, 2.06 [95% CI, 1.06–4.00] versus subarachnoid hemorrhage: reference) remained independently associated with poor functional outcome. In contrast, a time between stroke diagnosis and initiation of mechanical ventilation >1 day was protective (OR, 0.56 [95% CI, 0.33–0.94]). A sensitivity analysis conducted after exclusion of patients with early decisions of withholding/withdrawal of care yielded similar results. We observed persistent physical and psychological problems at 1 year in >50% of survivors. CONCLUSIONS: In patients with severe stroke requiring mechanical ventilation, several ICU admission variables may inform caregivers, patients, and their families on post-ICU trajectories and functional outcomes. The burden of persistent sequelae at 1 year reinforces the need for a personalized, multi-disciplinary, prolonged follow-up of these patients after ICU discharge. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03335995

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2023
• Auteurs : Justyna Elżbieta JońcaKevin Castelló LuxKatia FajerwergMyrtil L KahnV. CollièrePhilippe MeniniIzabela SówkaPierre Fau
• Organismes : Wroclaw University of Science and Technology Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination Laboratoire de chimie de coordination Équipe MICrosystèmes d'Analyse Wroclaw University of Science and Technology Laboratoire de physique et chimie des nano-objets
• Publié dans Chemosensors le 21/10/2020

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Résumé : The nanometer size Cu2O@WO3·H2O composite material has been prepared by the direct hydrolysis of mesitylcopper (I) on WO3·2H2O nanoleaves. The synthesis has been performed in toluene without the addition of any ancillary ligands. The prepared nanocomposite has been deposited as a gas-sensitive layer on miniaturized silicon devices and heated up gradually to 500 °C in the ambient air. During the heating, the CuWO4 phase is formed upon the reaction of Cu2O with the WO3 support as revealed by the XRD analyses. The as-prepared CuWO4@WO3 sensors have been exposed to 10 ppm of CO or 0.4 ppm of NO2 (RH = 50%). At the operating temperature of 445 °C, a normalized response of 620% towards NO2 is obtained whereas the response to CO is significantly lower (S = 30%). Under these conditions, the sensors prepared either with pristine CuO or WO3 nanostructures are sensitive to only one of the two investigated gases, i.e., CO and NO2, respectively. Interestingly, when the CuWO4@WO3 sensitive layer is exposed to UV light emitted from a 365 nm Schottky diode, its sensitivity towards CO vanishes whereas the response towards NO2 remains high. Thus, the application of UV illumination allowed us to modify the selectivity of the device. This new nanocomposite sensor is a versatile sensitive layer that will be integrated into a gas sensor array dedicated to electronic nose platforms.

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Fichiers liés : Jońca, Gas sensing properties, 2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2023
• Auteurs : Pauline Lallemant-DudekLivia ParodiGiulia CoarelliAnna HeinzmannPerrine CharlesClaire EwenczykSilvia FenuMarie-Lorraine MoninPhilippe CorciaChristel DepienneFanny MochelJean BenardSophie Tezenas Du MontcelAlexandra Dürr
• Organismes : Sorbonne Université Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Hôpital Bretonneau Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Association Strümpell-Lorrain Algorithms, models and methods for images and signals of the human brain = Algorithmes, modèles et méthodes pour les images et les signaux du cerveau humain [ICM Paris] Institut Pierre Louis d'Epidémiologie et de Santé Publique
• Publié dans Annals of Physical and Rehabilitation Medicine le 02/11/2020

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Résumé : Background: Phenotypic variability is a consistent finding in neurogenetics and therefore applicable to hereditary spastic paraparesis. Identifying reasons for this variability is a challenge. We hypothesized that, in addition to genetic modifiers, extrinsic factors influence variability. Objectives: Our aim was to describe the clinical variability in hereditary spastic paraparesis from the person's perspective. Our goals were to identify individual and environmental factors that influence muscle tone disorders and derive interventions which could improve spasticity. Methods: This study was based on self-assessments with questions on nominal and ordinal scales completed by participants with hereditary spastic paraparesis. A questionnaire was completed either in-person in the clinic or electronically via lay organization websites. Results: Among the 325 responders, most had SPG4/SPAST (n = 182, 56%) with a mean age at onset of 31.7 (SD 16.7) years and a mean disease duration of 23 (SD 13.6) years at the time of participation. The 2 factors identified as improving spasticity for > 50% of the responders were physiotherapy (193/325, 59%), and superficial warming (172/308, 55%). Half of the responders (n = 164, 50%) performed physical activity at least once a month and up to once a week. Participants who reported physiotherapy as effective were significantly more satisfied with ≥ 3 sessions per week. Psychologically stressful situations (246/319, 77%) and cold temperatures (202/319, 63%) exacerbated spasticity for most participants. Conclusion: Participants perceived that physiotherapy reduced spasticity and that the impact of physiotherapy on spasticity was much greater than other medical interventions. Therefore, people should be encouraged to practice physical activity at least 3 times per week. This study reported participants' opinions: in hereditary spastic paraparesis only functional treatments exist, therefore the participant's expertise is of particular importance.

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Fichiers liés : AnnalesMPR_Modifspa_manuscript.v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2023
• Auteurs : Coralie BlochJean Philippe JaisMarine GilMarouane BoubayaYves LepelletierBrigitte Bader-MeunierNizar MahlaouiNicolas GarcelonOlivier LambotteDavid LaunayClaire LarrocheEstibaliz LazaroFrancois LiffermannOlivier LortholaryMarc MichelJean-Marie MichotPierre MorelMorgane CheminantFelipe SuarezLouis TerriouGeoffrey UrbanskiJean-Francois ViallardAlexandre AlcaisAlain FischerGeneviève de Saint BasileOlivier HermineCoralie BlochJean Philippe JaisFrancois LiffermannPierre MorelMorgane CheminantFelipe SuarezOlivier HermineFabrice BonnetPascal GodemerDamaj GandhiOlivier FainOlivier LambotteDavid LaunayLouis TerriouClaire LarrocheEstibaliz LazaroJean-Francois ViallardFrancois LiffermannOlivier LortholaryMarc MichelJean-Marie MichotPierre MorelFrederic PeneAntoinette PerlatGeoffrey Urbanski
• Organismes : Centre de Recherche des Cordeliers Imagine - Institut des maladies génétiques Institute for Translational Research in Inflammation - U 1286 Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nutrition, Métabolismes et Cancer Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes
• Publié dans Journal of Allergy and Clinical Immunology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2023
• Auteurs : Laurent BoubyLucie ChabalVincent BonhommeIsabelle BalyJanet BattentierSammy Ben MakhadEmmanuelle BonnaireManon CabanisCécile CallouCarine Cenzon-SalvayreS. CoubrayGeneviève DaoulasDelhon ClaireMarie DerreumauxPriscille DhesseMarie-France DietschAlexa DufraisseAline DurandFrédérique DurandIsabel FigueiralLaurie FlottesIsabelle GillotCharlotte HallavantAuréade HenryAngèle JeantyFlorian JedrusiakLéonor LiottierPhilippe MarinvalLucie MartinElsa NeveuLaure ParadisRachel Pinaud-Querrac'HPhilippe PoirierBénédicte PradatSidonie PreissNuria Rovira BuendiaJérôme RosAurélie SalavertCaroline SchaalStéphanie ThiébaultMargaux TillierFrançoise ToulemondeChristophe VaschaldeJulian WietholdMarie-Pierre RuasVéronique Zech-Matterne
• Organismes : Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier Bases de données sur la Biodiversité, Ecologie, Environnement et Sociétés BioArchéologie, Interactions Sociétés Environnements BioArchéologie, Interactions Sociétés Environnements BioArchéologie, Interactions Sociétés Environnements Archéologie d'Alsace Institut national de recherches archéologiques préventives Laboratoire de Géographie Physique et Environnementale Bases de données sur la Biodiversité, Ecologie, Environnement et Sociétés BioArchéologie, Interactions Sociétés Environnements Institut national de recherches archéologiques préventives BioArchéologie, Interactions Sociétés Environnements Institut national de recherches archéologiques préventives BioArchéologie, Interactions Sociétés Environnements Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Centre de Recherche Archéologique de la Vallée de l'Oise BioArchéologie, Interactions Sociétés Environnements Archéologie d'Alsace Institut national de recherches archéologiques préventives BioArchéologie, Interactions Sociétés Environnements Le Mans Université Centre de Recherche en Archéologie, Archéosciences, Histoire Institut national de recherches archéologiques préventives Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives Institut des Sciences de l'Evolution de Montpellier Archeodunum Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Hadès - Bureau d'Investigations Archéologiques Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Institut des Sciences de l'Evolution de Montpellier Archéologies et Sciences de l'Antiquité Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes Université de Genève = University of Geneva Environnements, Dynamiques et Territoires de Montagne Centre de Recherche en Archéologie, Archéosciences, Histoire University College London [UCL] Institut des Sciences de l'Evolution de Montpellier Archéologie des Sociétés Méditerranéennes Institut national de recherches archéologiques préventives Institut des Sciences de l'Evolution de Montpellier BioArchéologie, Interactions Sociétés Environnements Institut national de recherches archéologiques préventives Institut Royal des Sciences Naturelles de Belgique = Royal Belgian Institute of Natural Sciences Archéologie des Sociétés Méditerranéennes Institut des Sciences de l'Evolution de Montpellier BioArchéologie, Interactions Sociétés Environnements Laboratoire Chrono-environnement (UMR 6249) Trajectoires - UMR 8215 IPSO FACTO [Marseille] Archéologie des Sociétés Méditerranéennes BioArchéologie, Interactions Sociétés Environnements Mosaïques Archéologie Laboratoire d'Archéologie Médiévale et Moderne en Méditerranée Institut national de recherches archéologiques préventives Archéologie, Terre, Histoire, Sociétés [Dijon] BioArchéologie, Interactions Sociétés Environnements BioArchéologie, Interactions Sociétés Environnements
• Publié dans Palaeogeography, Palaeoclimatology, Palaeoecology le 02/11/2020

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Résumé : Grapevine and wine have deeply shaped the landscapes, economy and cultures of Europe and the Mediterranean. In France, it is considered that viticulture started in the south via contacts with Mediterranean populations (Greeks, Etruscans, Phoenicians), during the second half of the 1st millennium BCE, and spread further with the Romans. Wild grapevines were nevertheless present in various areas of the country all through the Holocene. No archaeological or historical source allows us to follow the history of grapevine and viticulture over the entire Holocene period and over the whole territory.In this paper we investigate the potential of archaeological plant macroremains (seed/fruits and wood) to trace the history of the vine on a large scale. We have assembled the largest possible database of published and unpublished archaeobotanical data, comprising 4449 site-phases for seed and fruits and 1356 site-phases for wood remains. In spite of taphonomic discrepancies and imbalances in the datasets, the different types of macroremains and modes of preservation produce consistent patterns. They provide the first comprehensive picture of the spread of grapevine, fluctuations in the economic role of viticulture and grape uses over time, although some periods and regions are less documented.Grapevine remains are regularly recorded from the Mesolithic to the Iron Age in most regions showing that human societies were already familiar with the wild plant and its fruits, especially in the Mediterranean. In this region, Vitis remains become considerably more frequent and numerous during the Iron Age, from around 500 BCE onwards, testifying to the rapid and strong implantation of viticulture. Grapevine macroremains confirm that the spread of viticulture outside the Mediterranean area occurred mainly during the Roman period. However, this expansion was limited and mainly focused on the South. The main expansion into the temperate zone took place during the Middle Ages. However, the more detailed fluctuations of viticulture, particularly in relation to climate oscillations are still difficult to follow. Pip remains are mainly associated with urban sites. This is a consequence of the actual consumption of grapes and may be evidence of a viticulture centered around urban areas.

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Fichiers liés : Bouby_et_al2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/08/2023
• Auteurs : Guillaume FondMélanie FaugereLaurent BoyerPauline PeriFlorian StephanFanny MoliereLoic AnguillDjamila BennabiEmmanuel HaffenAlexandra BouvardMichel WalterLudovic SamalinPierre-Michel LlorcaJean Baptiste GentyMarion LeboyerJérôme HoltzmannAnne Sophie NguonRomain ReyMathilde HornGuillaume VaivaVincent HennionB EtainWissam El-HageVincent CamusPhilippe CourtetBruno AouizerateAntoine YrondiChristophe LançonRaphaelle Richieri
• Organismes : Centre d'études et de recherche sur les services de santé et la qualité de vie Hôpital Sainte-Marguerite [CHU - APHM] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Hôpital Sainte-Marguerite [CHU - APHM] Fondation FondaMental [Créteil] Centre d'études et de recherche sur les services de santé et la qualité de vie Hôpital Sainte-Marguerite [CHU - APHM] Fondation FondaMental [Créteil] Hôpital Sainte-Marguerite [CHU - APHM] Fondation FondaMental [Créteil] Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Fondation FondaMental [Créteil] Neuropsychiatrie : recherche épidémiologique et clinique Fondation FondaMental [Créteil] Toulouse NeuroImaging Center Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Laboratoires de neurosciences intégratives et cliniques (EA 481) Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Laboratoires de neurosciences intégratives et cliniques (EA 481) Fondation FondaMental [Créteil] Nutrition et Neurobiologie intégrée Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Université Grenoble Alpes Fondation FondaMental [Créteil] Université Grenoble Alpes Fondation FondaMental [Créteil] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier le Vinatier [Bron] Fondation FondaMental [Créteil] Service de Psychiatrie [CHRU Lille] Fondation FondaMental [Créteil] Service de Psychiatrie [CHRU Lille] Centre National de Ressources et de Résilience [Lille] Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Université Paris Cité Optimisation thérapeutique en Neuropsychopharmacologie Hôpital Lariboisière-Fernand-Widal [APHP] Fondation FondaMental [Créteil] Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Régional Universitaire de Tours Fondation FondaMental [Créteil] Imaging, Brain & Neuropsychiatry Centre d’Investigation Clinique [Tours] CIC 1415 Centre Hospitalier Régional Universitaire de Tours Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Neuropsychiatrie : recherche épidémiologique et clinique Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Toulouse NeuroImaging Center Fondation FondaMental [Créteil] Hôpital Sainte-Marguerite [CHU - APHM] Fondation FondaMental [Créteil] Hôpital Sainte-Marguerite [CHU - APHM] Institut FRESNEL École Centrale de Marseille Imagerie MOléculaire pour applications THéranostiques personnalisées
• Publié dans Progress in Neuro-Psychopharmacology and Biological Psychiatry le 25/10/2020

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Résumé : Background: Benzodiazepine long-term use (BLTU) is a public health challenge. We lack data on the consequences of LBTU on the trajectory of treatment-resistant depression (TRD).Objective: To determine the prevalence of BLTU in a nationwide non-selected population of patients with TRD, to determine the rate of patients succeeding at withdrawing benzodiazepines at one year and to determine if persistent BLTU is associated with poorer mental health outcomes.Method: The FACE-TRD cohort is a national cohort of TRD patients recruited in 13 resistant depression expert centers between 2014 and 2021 and followed-up at one year. A standardized one-day long comprehensive battery was carried out, including trained-clinician and patient-reported outcomes, and patients were reevaluated at one year.Results: At baseline, 45.2% of the patients were classified in the BLTU group. In multivariate analysis, compared to patients without BLTU, patients with BLTU were more frequently classified in the "low physical activity" group (adjusted odds ratio (aOR) = 1.885, p = 0.036), and had higher primary healthcare consumption (B = 0.158, p = 0.031) independently of age, sex and antipsychotic consumption. We found no significant difference for personality traits, suicidal ideation, impulsivity, childhood trauma exposure, earlier age at first major depressive episode, anxiety and sleep disorders (all p > 0.05). Despite recommendations for withdrawal, <5% of BLTU patients withdraw benzodiazepines during the one-year follow-up. Persistent BLTU at one-year was associated with higher depression severity (B = 0.189, p = 0.029), higher clinical global severity (B = 0.210, p = 0.016), higher state-anxiety (B = 0.266, p = 0.003), impaired sleep quality (B = 0.249, p = 0.008), increased peripheral inflammation (B = 0.241, p = 0.027), lower functioning level (B = -0.240, p = 0.006), decreased processing speed (B = -0.195, p = 0.020) and verbal episodic memory (B = -0.178, p = 0.048), higher absenteeism and productivity loss (B = 0.595, p = 0.016) and lower subjective global health status (B = -0.198, p = 0.028).Conclusion: Benzodiazepines are over-prescribed in TRD (in almost a half of the patients). Despite recommendations for withdrawal and psychiatric follow-up, <5% of patients successfully stopped taking benzodiazepines at one-year. Maintaining BLTU may contribute to the worsening of clinical and cognitive symptoms and of daily functioning in TRD patients. Progressive and planed withdrawal of benzodiazepines seems therefore strongly recommended in TRD patients with BLTU. Pharmacological and non-pharmacological alternatives should be promoted when possible.

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Fichiers liés : S0278584623000659.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/08/2023
• Auteurs : Bruno RevolThéo WillemanMarc ManceauVéronique Dumestre-TouletJean-Michel GaulierNathalie Fouilhé Sam-LaïHélène Eysseric-GuérinChadi AbbaraDelphine AllorgeJean-Claude AlvarezAlice AmelineAurélie AquizerateAnne BarretEmilie BerlandCélian BertinThierry BesnardFabien BevalotCamille Billet-ChatenayÉmilie BouquetJoanna BourgineBertrand BrunetAnne-Sylvie CaousAlexandre CesbronLeila ChaouachiCécile ChevallierMarjorie ChezeAntony Citterio-QuentinPhilippe Collon-FabieEric DaillyAmélie DaveluyGrégory DeffontaineMartine DelageXavier DelavenneFlorence DescampsJuliette DescoeurGuillaume DeslandesMarc DeveauxBernadette DevosChristophe DocheCéline EidenAurélie FouleyYvan GaillardNicolas GambierCatherine GanièreJean-Pierre GoulléPascal GuerardGuillaume HoizeyLuc HumbertLaurent ImbertMarie-France KerguerisPascal KintzFlorian KlinzigLaurence Labat-DeveauxBruno LacarelleChristian LacroixDenis LamiableMichel LavitReynald Le BoisselierAnne Le BouilCatherine Le MeurSandrine LefeuvreBénédicte LelièvreVéronique Lelong-BoulouardAnne-Sophie Lemaire-HurtelJuliana Lima-TournebizeMagalie LoilierVincent LopezClaire Martin-MolinsHélène MartyOlivier MathieuJean-Claude Mathieu-DaudéYves MaurasNathalie MilanAurélie MoalIsabelle MorelPatrick MuraAnne-Laure Pelissier-AlicotGilbert PépinMartine PerrinAnne PeyreAlain PineauRop PokCatherine Ragoucy-SenglerRaphaël RayerEmilie RomanCarine RousselAnne RoussinSandrine SabiniElodie SaussereauJulien Scala-BertolaPauline SibilleMichel SpadariKarine TitierAlain TurcantPierrick VacherNicolas VenisseOphélie VieiraPascale Visinoni
• Organismes : Université Grenoble Alpes - UFR Médecine Centre Hospitalier Universitaire [CHU Grenoble] Hypoxie et PhysioPathologie Centre Hospitalier Universitaire [CHU Grenoble] Department of Biosystems Science and Engineering [ETH Zürich] Laboratoire ToxGen Impact de l'environnement chimique sur la santé humaine - ULR 4483 Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Universitaire d'Angers Impact de l'environnement chimique sur la santé humaine - ULR 4483 Centre de recherche en épidémiologie et santé des populations Hôpital Raymond Poincaré (Garches) [GHU AP-HP Université Paris-Saclay] Institut de Médecine Légale [Strasbourg] Laboratoire de pharmacologie et toxicologie neurocardiovasculaire Centre d'évaluation et d'information sur la pharmacodépendance-addictovigilance [CHU de Nantes] Centre Hospitalier Universitaire [CHU Grenoble] Service National de la Police Scientifique CHU Clermont-Ferrand Neuro-Dol Laboratoire Lat Lumtox Centre d’évaluation et d’information sur la pharmacodépendance – addictovigilance de Poitiers [CHU de Poitiers] Laboratoire de neurosciences expérimentales et cliniques [U 1084] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Département de Pharmacologie [CHU Caen] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 0802) Centre Hospitalier Régional Universitaire [CHU Lille] Centre d’Evaluation et d’Information sur la Pharmacodépendance (CEIP-A) et d’Addictovigilance de Paris Centre antipoison et de toxicovigilance (Lyon) Laboratoire de Pharmacologie et Toxicologie Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Cibles et Médicaments des Infections et de l'Immunité - UR 1155 Bordeaux population health Service de Biochimie et d'Hormonologie [CHU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Université Jean Monnet - Saint-Étienne Santé Ingénierie Biologie Saint-Etienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] École Pratique des Hautes Études Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Infections Respiratoires Fongiques SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques
• Publié dans JAMA Network Open le 29/10/2020

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Résumé : Importance: The DRAMES (Décès en Relation avec l’Abus de Médicaments Et de Substances) register is a database of drug-related deaths with the aim of identifying the psychoactive substances associated with and estimating the trends in these deaths. Our novel approach is based on the collection of data on all deaths for which toxicology experts have performed analyses. Objective: To describe drug-related deaths in France and report trends over an 11-year period. Design, Setting, and Participants: This case series used a national register to assess 4460 drug-related deaths that occurred from 2011 to 2021 in France. Data analyses were performed from January 1, 2012, to December 31, 2022. Main Outcomes and Measures: Demographic characteristics; medical and substance abuse history; forensic autopsy findings; and toxicology reports. Results: Among the 4460 deceased individuals (mean [SD] age, 37.8 [10.5] years), the mortality rate was highest among men (sex ratio, 4.4:1). Of the deaths involving a single or predominant drug, the legal substitution product, methadone, was the leading cause of death during the entire study period, ahead of heroin—44.7% and 35.9% for methadone vs 15.8% and 21.8% for heroin in 2011 and 2021, respectively. Between 2011 and 2021, most of the drug-related deaths shifted from licit to illicit drugs, and statistically significant variations were found for buprenorphine, cocaine, heroin, methadone, and other licit opioids. Deaths related to polydrug use increased from 23.2% in 2011 to 30.6% in 2021. In this context, opioids remained associated with most deaths, with at least 1 opioid being involved in approximately 9 of 10 cases (85.9%) in 2021. However, the main trend was the dramatic increase in drug combinations with cocaine, from less than one-third of cases in 2011 (30.8%) to more than half in 2021 (57.8%). Conclusions and Relevance: This case series assessment of 4460 drug-related deaths found that opioids used alone or in combination were the main contributor to drug-related deaths, despite having a lower prevalence than other drugs. This finding is similar to that of other countries; however, in France licit methadone was the leading cause of opioid-related deaths (ahead of heroin) during the study period. Deaths associated with use of cannabis, new psychoactive substances, and stimulants (including amphetamine-type stimulants and cocaine, especially in combination) have increased and should be closely monitored.

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Fichiers liés : revol_2023_oi_230912_1692815036.31231.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 29/08/2023
• Auteurs : Tristan RigautPierre CarpentierJean-Philippe ChancelierMichel de Lara
• Organismes : Schneider Electric Optimisation et commande Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique Centre d'Enseignement et de Recherche en Mathématiques et Calcul Scientifique
• Publié dans Computational Management Science le 30/10/2020

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Résumé : It is common that strategic investment decisions are made at a slow time-scale, whereas operational decisions are made at a fast time-scale. Hence, the total number of decision stages may be huge. In this paper, we consider multistage stochastic optimization problems with two time-scales, and we propose a time block decomposition scheme to address them numerically. More precisely, i) we write recursive Bellman-like equations at the slow time-scale and ii), under a suitable monotonicity assumption, we propose computable upper and lower bounds — relying respectively on primal and dual decomposition — for the corresponding slow time-scale Bellman functions. With these functions, we are able to design policies. We assess the methods tractability and validate their efficiency by solving a battery management problem where the fast time-scale operational decisions have an impact on the storage current capacity, hence on the strategic decisions to renew the battery at the slow time-scale.

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Fichiers liés : dynamically_monotone_two-time_scales_hal_v2.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 29/08/2023
• Auteurs : Laurent BoubyNicolas BernigaudLucie ChabalAlberte BondeauFabrice BigotManon CabanisCharlotte CarratoCarine Cenzon-SalvayreJulien Chardonneau- HenneuseDelhon ClaireFrédérique DurandIsabel FigueiralLaurie FlottesJustine GomesCharlotte HallavantAuréade HenryLéonor LiottierPhilippe MarinvalLaure ParadisPinaud-Querrac’h RaquelPhilippe PoirierJérôme RosMarie-Pierre RuasPierre SéjalonJean-Frédéric TerralMargaux TillierMagali ToritiChristophe VaschaldeJoel GuiotNuria Rovira BuendiaStéphane Mauné
• Organismes : Institut des Sciences de l'Evolution de Montpellier Archéologie des Sociétés Méditerranéennes Institut des Sciences de l'Evolution de Montpellier Institut méditerranéen de biodiversité et d'écologie marine et continentale Archéologie des Sociétés Méditerranéennes Institut national de recherches archéologiques préventives Mosaïques Archéologie Independant Researcher, Anthracomed, 13090, Aix-en-Provence, France Archéologie des Sociétés Méditerranéennes Institut des Sciences de l'Evolution de Montpellier Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives Institut national de recherches archéologiques préventives Institut des Sciences de l'Evolution de Montpellier Archeodunum Archéologie des Sociétés Méditerranéennes HADES Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Culture et Environnements, Préhistoire, Antiquité, Moyen-Age Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes Institut des Sciences de l'Evolution de Montpellier Archéologie des Sociétés Méditerranéennes Institut national de recherches archéologiques préventives - Centre de recherches archéologiques de Villeneuve-lès-Béziers Institut des Sciences de l'Evolution de Montpellier Institut des Sciences de l'Evolution de Montpellier BioArchéologie, Interactions Sociétés Environnements Archéologie des Sociétés Méditerranéennes Institut national de recherches archéologiques préventives Institut des Sciences de l'Evolution de Montpellier IPSO FACTO [Marseille] Centre de Recherche en Archéologie, Archéosciences, Histoire Mosaïques Archéologie Laboratoire d'Archéologie Médiévale et Moderne en Méditerranée Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Archéologie des Sociétés Méditerranéennes Archéologie des Sociétés Méditerranéennes

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