Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2023
• Auteurs : Guillaume ChassagnonMostafa El HajjamSamia BoussouarMarie-Pierre RevelRalph KhouryBenoît GhayeSébastien BommartMathieu LederlinStephane Tran BaConstance de Margerie-MellonLaure FournierLucie CassagnesMickaël OhanaCarole JalaberGaël DournesNicolas CazeneuveGilbert Raymond FerrettiPauline TalabardVictoria DonciuEmma CanniffMarie-Pierre DebrayBernard CrutzenJérémy CharriotValentin RabeauPhilippe KhafagyRichard ChocronIan Leonard-LorantLoic MetairyLea Ruez-LantuejoulSebastien BeaunePierre HausfaterAnne‐laure PhilipponAntoine KhalilAndrea PenalozaThibaut AffolePierre Yves BrilletCatherine RoyJulien PucheuxJordan ZbiliOlivier SanchezRaphaël Porcher
• Organismes : Service de Radiologie [CHU Cochin] Université Paris Cité Hôpital Ambroise Paré [AP-HP] Université Paris-Saclay Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] Laboratoire d'Imagerie Biomédicale [Paris] Service de Radiologie [CHU Cochin] Université Paris Cité Département de Radiologie [Bichat] Université Paris Cité Cliniques Universitaires Saint-Luc [Bruxelles] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Hôpital Arnaud de Villeneuve [CHU Montpellier] Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes] Département de Radiologie [Rennes] Service de radiologie [Avicenne] Service de radiologie [Saint-Louis] Paris-Centre de Recherche Cardiovasculaire Service Imagerie Médicale et Radiologie Interventionnelle - site Gabriel-Montpied [CHU Clermont-Ferrand] Thérapie guidée par l'image Nouvel Hôpital Civil de Strasbourg Université de Strasbourg Service de Radiologie [CHU Saint-Etienne] Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] Hôpital Haut-Lévêque [CHU Bordeaux] Hôpital Trousseau BrainTech Laboratory [CHU Grenoble Alpes - Inserm U1205] Hôpital Ambroise Paré [AP-HP] Université Paris-Saclay CHU Pitié-Salpêtrière [AP-HP] Service de Radiologie [CHU Cochin] Université Paris Cité Département de Radiologie [Bichat] Université Paris Cité Cliniques Universitaires Saint-Luc [Bruxelles] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Département pneumologie et addictologie [Montpellier] Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes] Département de Radiologie [Rennes] Service de radiologie [Avicenne] Hôpital Européen Georges Pompidou [APHP] Nouvel Hôpital Civil de Strasbourg Hôpital Trousseau Centre Hospitalier Universitaire [CHU Grenoble] Hôpital Ambroise Paré [AP-HP] Université Paris-Saclay CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe de recherche clinique Biomarqueurs d’urgence et de réanimation Hôpital Cochin [AP-HP] Université Paris Cité Département de Radiologie [Bichat] Université Paris Cité Cliniques Universitaires Saint-Luc [Bruxelles] Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes] Département de Radiologie [Rennes] Service de radiologie [Avicenne] Hypoxie et Poumon : pneumopathologies fibrosantes, modulations ventilatoires et circulatoires Nouvel Hôpital Civil de Strasbourg Hôpital Trousseau Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes] Département de Radiologie [Rennes] Hôpital Européen Georges Pompidou [APHP] Université Paris Cité Centre d'épidémiologie Clinique [Hôtel-Dieu] Université Paris Cité
• Publié dans European Radiology le 23/10/2020

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Résumé : Objectives: The objective was to define a safe strategy to exclude pulmonary embolism (PE) in COVID-19 outpatients, without performing CT pulmonary angiogram (CTPA). Methods: COVID-19 outpatients from 15 university hospitals who underwent a CTPA were retrospectively evaluated. D-Dimers, variables of the revised Geneva and Wells scores, as well as laboratory findings and clinical characteristics related to COVID-19 pneumonia, were collected. CTPA reports were reviewed for the presence of PE and the extent of COVID-19 disease. PE rule-out strategies were based solely on D-Dimer tests using different thresholds, the revised Geneva and Wells scores, and a COVID-19 PE prediction model built on our dataset were compared. The area under the receiver operating characteristics curve (AUC), failure rate, and efficiency were calculated. Results: In total, 1369 patients were included of whom 124 were PE positive (9.1%). Failure rate and efficiency of D-Dimer > 500 μg/l were 0.9% (95%CI, 0.2-4.8%) and 10.1% (8.5-11.9%), respectively, increasing to 1.0% (0.2-5.3%) and 16.4% (14.4-18.7%), respectively, for an age-adjusted D-Dimer level. D-dimer > 1000 μg/l led to an unacceptable failure rate to 8.1% (4.4-14.5%). The best performances of the revised Geneva and Wells scores were obtained using the age-adjusted D-Dimer level. They had the same failure rate of 1.0% (0.2-5.3%) for efficiency of 16.8% (14.7-19.1%), and 16.9% (14.8-19.2%) respectively. The developed COVID-19 PE prediction model had an AUC of 0.609 (0.594-0.623) with an efficiency of 20.5% (18.4-22.8%) when its failure was set to 0.8%. Conclusions: The strategy to safely exclude PE in COVID-19 outpatients should not differ from that used in non-COVID-19 patients. The added value of the COVID-19 PE prediction model is minor.

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Fichiers liés : 2023 Chassagnon et al Strategies to safely.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2023
• Auteurs : Astrid Boulenger de HauteclocqueLoic FerrerDamien AmbrosettiSolene RicardPierre BigotKarim BensalahFrançois HenonNicolas DoumercArnaud MéjeanVirginie VerkarreCharles DarianeStéphane LarréCécile Maud ChampyAlexandre de La TailleFranck BruyèreMorgan RoupretPhilippe PaparelStéphane DroupyAlexis FontenilJean-Jacques PatardXavier DurandThibaut WaeckelHervé LangCédric LebacleLaurent GuyGéraldine PignotMatthieu DurandJean-Alexandre LongThomas CharlesÉvanguelos XylinasRomain BoissierMokrane YacoubThierry ColinJean-Christophe Bernhard
• Organismes : service d'urologie [CHU Bordeaux] SOPHiA GENETICS [Pessac] Centre Hospitalier Universitaire de Nice service d'urologie [CHU Bordeaux] Centre Hospitalier Universitaire d'Angers Service d'urologie [Rennes] = Urology [Rennes] Service d'Urologie, andrologie et transplantation rénale [CHRU Lille] Département d'Urologie-Andrologie et Transplantation Rénale [CHU Toulouse] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Hôpital universitaire Robert Debré [Reims] Hôpital Henri Mondor Hôpital Henri Mondor Service d'urologie [Tours] CHU Pitié-Salpêtrière [AP-HP] Service d'urologie [Centre Hospitalier Lyon Sud - HCL] Centre Hospitalier Universitaire de Nîmes Université de Montpellier Centre Hospitalier Universitaire de Nîmes CHU Mont de Marsan Imagerie Moléculaire et Stratégies Théranostiques Centre hospitalier Saint-Joseph [Paris] Service d'Urologie [CHU Caen] Service d'Urologie [Strasbourg] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Imagerie Moléculaire et Stratégies Théranostiques Service Urologie [CHU Clermont-ferrand] Institut Paoli-Calmettes Centre Hospitalier Universitaire de Nice Service d'urologie [CHU Grenoble] Service d'urologie [CHU de Poitiers] AP-HP - Hôpital Bichat - Claude Bernard [Paris] CHU Marseille Service de pathologie [Bordeaux] SOPHiA GENETICS [Pessac] service d'urologie [CHU Bordeaux]
• Publié dans BJU International le 28/10/2020

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Résumé : Objectives: To assess the impact of pathological upstaging from clinically localized to locally advanced pT3a on survival in patients with renal cell carcinoma (RCC), as well as the oncological safety of various surgical approaches in this setting, and to develop a machine-learning-based, contemporary, clinically relevant model for individual preoperative prediction of pT3a upstaging. Materials and Methods: Clinical data from patients treated with either partial nephrectomy (PN) or radical nephrectomy (RN) for cT1/cT2a RCC from 2000 to 2019, included in the French multi-institutional kidney cancer database UroCCR, were retrospectively analysed. Seven machine-learning algorithms were applied to the cohort after a training/testing split to develop a predictive model for upstaging to pT3a. Survival curves for disease-free survival (DFS) and overall survival (OS) rates were compared between PN and RN after G-computation for pT3a tumours. Results: A total of 4395 patients were included, among whom 667 patients (15%, 337 PN and 330 RN) had a pT3a-upstaged RCC. The UroCCR-15 predictive model presented an area under the receiver-operating characteristic curve of 0.77. Survival analysis after adjustment for confounders showed no difference in DFS or OS for PN vs RN in pT3a tumours (DFS: hazard ratio [HR] 1.08, P = 0.7; OS: HR 1.03, P > 0.9). Conclusions: Our study shows that machine-learning technology can play a useful role in the evaluation and prognosis of upstaged RCC. In the context of incidental upstaging, PN does not compromise oncological outcomes, even for large tumour sizes.

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Fichiers liés : BJU International - 2023 - Boulenger de Hauteclocque - Machine‐learning approach for prediction of pT3a upstaging and.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2023
• Auteurs : Friederike PetzoldKaty BillotXiaoyi ChenCharline HenryEmilie FilholYoann MartinMarina AvramescuMaxime DouilletVincent MorinièrePauline KrugCécile JeanpierreKalman ToryOlivia BoyerAnita BurgunAude ServaisRemi SalomonAlexandre BenmerahLaurence HeidetNicolas GarcelonCorinne AntignacMohamad ZaidanSophie SaunierTania Attié-BitachValerie Comier-DaireIsabelle PerraultYaacov FrishbergBrigitte LlanasMichel BroyerNabil MohsinMarie-Alice MacherNicole PhilipVéronique BaudouinDamian BrackmanChantal LoiratMarina CharbitMaud DehennaultClaude GuyotPierre BatailleMariet EltingGeorges DeschenesAndrea GropmanGeneviève GuestMarie-France GagnadouxPhilippe NicoudPierre CochatBruno RanchinAlbert BensmanAnne-Marie GuerrotBertrand KnebelmannIlmay BilgeDanièle BrunoStéphane BurteyCaroline Rousset RouvièreValérie CaudwellDenis MorinHélène DollfusAnne MaisinChristian HamelEric BiethSophie GieJudith GoodshipGwenaelle RousseyHermine La SelveHubert NivetLucie BessenayMathilde CaillezJean Bernard PalcouxStéphane BenoîtPhilippe DubotMarc FilaFabienne GiulianoDaouya IfteneMichele KesslerTheresa KwonAnine LahocheAudrey LaurentAnne-Laure LeclercDavid MilfordThomas NeuhausSylvie OdentPhilippe EckartDominique ChauveauPatrick NiaudetHoracio RepettoSophie TaqueAlexandra BruelAlexandra Noel-BotteEmma Allain LaunayLisa AllardDany AnlicheauAnne-Laure AdraArnaud GarnierArvind NagraRemy BaatardJustine BacchettaBanu SadikogluChristine BarneriasAnne BarthelemyLina BaselNader BassiliosHedi Ben MaizFatma Ben MoussaFaïza BenmatiRomain BerthaudAurélia BertholetDominique BlanchierJean Jacques BoffaKarim BouchirebIhab BouhabelZakaria BoukerrouchaGuylhène Bourdat-MichelOdile BouteKarine BrochardRoseline CaumesSiham Chafai ElalaouiBernard ChamontinMarie Caroline ChastangChristine PietrementChristine RicherChristophe LegendreKarin DahanFabienne Dalla-ValeDamien ThibaudinMaxime DauvergneSalandre DavourieMartin DebeukelaerJean Daniel DelbetConstantinos DeltasDenis GraberNadège DevillarsBoucar DioufMartine Doco FenzyJean-Luc AndréDominique JolyAlan FryerLaetitia AlbanoElisabeth CassutoAline PinconAna MedeiraAnnabelle ChaussenotAnne Mensire-MarinierFrancois BouissouStéphane DecramerArmand BottaniAurélie HummelAlexandre KarrasAvi KatzChristine AzemaBénédicte JanbonBernard RousselClaude BonniolChristiophe MariatGérard ChampionDeborah ChantreuilNicolas ChassaingChristiane MoussonChristine BaudeauDelphine Hafdar CuntzCyril MignotLaurene DehouxDidier LacombeThierry HannedoucheElodie MérieauEmmanuelle CharlinEric GauthierFlorent PlasseStanislas FaguerFanny LebasFlorence DemurgerFrancesco EmmaFrançois CartaultGeneviève DumontNathalie GodefroidVincent GuigonisSophie HillaireJaap GroothoffJan DudleyNoémie Jourde-ChicheKhalil El KarouiSaoussen KridKrier CoudertLarbi BencheickLaurent YverMarie-Pierre LavocatLe Monies de SagazanValerie LeroyLise ThibaudinLiz IngulliLorraine GwanmesiaLydie BurglenMarie-Hélène Saïd-MenthonMarta CarreraMathilde NizonCatherine MelanderMichel FoulardMonique BlayoJacques PrinseauNadine JayNathalie BrunNicolas CamilleFrançois NobiliOlivier DevuystOuafa Ben BrahimPaloma ParvexLaurence Perrin SabourinPhilippe BlancPhilippe VanhillePierre GalichonSophie PierrepontVincent PlanquoisGwenaelle PoussardClaire Pouteil NobleRadia AllalRaphaelle BernardRaynaud MounetRémi CahenRenaud TouraineClaire RigothierAmélie RyckewaertMathieu SacquepeeSalima El ChehadehCharlotte SamailleShuman HaqAri SimckesStéphanie LanoiseléeStephanie TellierJean-François SubraSylvie CloarecJulie TenenbamThomas LamyValérie Drouin GarraudHuguette ValetteVanina MeyssonnierRosa Vargas-PoussouYves SnajerSandrine DuraultEmmanuelle PlaisierEtienne BerardFadi FakhouriFerielle LouilletPaul FinielzMichel FischbachBernard FoliguetHélène Francois-PradierFlorentine GaraixMarion GerardGianfranco RizzoniBrigitte Gilbert-DussardierDenis GlotzAstrid Godron DubrasquetJean-Pierre GrünfeldGuillaume BolleeMichelle HallSverker HanssonDamien HayeHélène TaffinFriedhelm HildebrandtMaryvonne HourmandHümya KayseriliIvan TackMarie Line JacquemontJennifer Fabre-TesteCliff KashtanKkoen van HoeckAlexandre KleinYannick KnefatiNine KnoersMartin KonradAlain LachauxIsabelle LandruGilbert LandthalerPhilippe LangPatrick Le PogampTristan LegrisCatherine DidaillerThierry LobbedezLoïc de ParscauLucile PinsonHervé MaheutMarc Duval-ArnouldMarlène RioMarie-Claire GublerPierre MervilleGuillaume MestralletMaite MeunierKarine MoreauJérôme HarambatGraeme MorganGeorges MouradNiksic StuberOdile Boespflug-TanguyOlivier DunandOlivier NielNacera OualiPaolo MalvezziPauline Abou JaoudeSolenne PelletierJulie PeltierM.B. PetersenPhilippe MichelPhilippe RémyJean-Baptiste PhilitValérie PichaultThierry Billette de VillemeurBernard BoudailliezBruno LeheupClaire DossierDjamal DjeddiYves BerlandBruno Hurault de LignySusan RigdenChristophe RobinoAnnick RossiSabine SarnackiMessaoud SaidaniAlbane Brodin SartoriusElise SchäferSztriha LaszloMarie-Christine ThouretAngélique Thuillier-LecoufHoward TrachtmanClaire TrivinMichel TsimaratosRita van Damme-LombaertsMarjolaine WillemsMichel YoussefAriane ZaloszycAlexis ZawodnikMarie-Julia Ziliotis
• Organismes : Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases University Hospital Leipzig = Universitätsklinikum Leipzig Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Imagine - Institut des maladies génétiques (IHU) Centre de Recherche des Cordeliers Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Département de Pédiatrie et maladies infectieuses [CHU Necker] Imagine - Institut des maladies génétiques (IHU) Centre de Recherche des Cordeliers Service de génétique moléculaire [CHU Necker] Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Département de Pédiatrie et maladies infectieuses [CHU Necker] Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Semmelweis University [Budapest] Département de Pédiatrie et maladies infectieuses [CHU Necker] Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Centre de Recherche des Cordeliers Service d'informatique médicale et biostatistiques [CHU Necker] PaRis Artificial Intelligence Research InstitutE (PRAIRIE), Paris, France. Centre de Référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte [CHU-Necker] Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Département de Pédiatrie et maladies infectieuses [CHU Necker] Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Département de Pédiatrie et maladies infectieuses [CHU Necker] Centre de Référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte [CHU-Necker] Centre de Recherche des Cordeliers Imagine - Institut des maladies génétiques Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases Service Néphrologie et transplantation rénale Adultes [CHU Necker] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Laboratoire des Maladies Rénales Héréditaires = Laboratory of Hereditary Kidney Diseases
• Publié dans Kidney International le 27/10/2020

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Résumé : Nephronophthisis (NPH) is an autosomal-recessive ciliopathy representing one of the most frequent causes of kidney failure in childhood characterized by a broad clinical and genetic heterogeneity. Applied to one of the worldwide largest cohorts of patients with NPH, genetic analysis encompassing targeted and whole exome sequencing identified disease-causing variants in 600 patients from 496 families with a detection rate of 71%. Of 788 pathogenic variants, 40 known ciliopathy genes were identified. However, the majority of patients (53%) bore biallelic pathogenic variants in NPHP1. NPH-causing gene alterations affected all ciliary modules defined by structural and/or functional subdomains. Seventy six percent of these patients had progressed to kidney failure, of which 18% had an infantile form (under five years) and harbored variants affecting the Inversin compartment or intraflagellar transport complex A. Forty eight percent of patients showed a juvenile (5-15 years) and 34% a late-onset disease (over 15 years), the latter mostly carrying variants belonging to the Transition Zone module. Furthermore, while more than 85% of patients with an infantile form presented with extra-kidney manifestations, it only concerned half of juvenile and late onset cases. Eye involvement represented a predominant feature, followed by cerebellar hypoplasia and other brain abnormalities, liver and skeletal defects. The phenotypic variability was in a large part associated with mutation types, genes and corresponding ciliary modules with hypomorphic variants in ciliary genes playing a role in early steps of ciliogenesis associated with juvenile-to-late onset NPH forms. Thus, our data confirm a considerable proportion of late-onset NPH suggesting an underdiagnosis in adult chronic kidney disease.

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Fichiers liés : S0085253823003770.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2023
• Auteurs : Laura PolivkaMarine MadrangeCristina Bulai-LivideanuStéphane BareteThomas BallulAntoine NeurazCeline GrecoJulie AgopianFabienne BrenetPatrice DubreuilCharles BurdetRichard LemalOlivier TournilhacLouis TerriouDavid LaunayLaurence BouilletClément GourguechonGhandi DamajLaurent FrenzelCécile MeniHassiba BouktitAnne Florence CollangeCaroline Gaudy-MarquesteMarie GousseffEdwige Le MouelMohamed HamidouAntoine NéelDana RantaRoland JaussaudPhilippe GuilpainDanielle CanioniThierry Jo MolinaJulie BruneauLudovic LhermitteNicolas GarcelonRose-Marie JavierFabien PelletierFlorence CastelainFrederique RetornazQuentin CabreraPatricia ZunicMarie Pierre GourinEwa Hainaut-WierzbickaJean François ViallardChristian LavigneCyrille HoarauIsabelle DurieuMaël HeibligSophie Dimicoli-SalazarJosé Miguel Torregrosa-DiazAngèle SoriaMichel ArockOlivier LortholaryChristine BodemerOlivier HermineJulien Rossignol
• Organismes : Institute for Translational Research in Inflammation - U 1286 Centre de Recherche des Cordeliers Imagine - Institut des maladies génétiques Immuno-Biologie des Lymphomes [CIRI] Service d’Hématologie [Centre Hospitalier Lyon Sud - HCL]
• Publié dans Journal of Allergy and Clinical Immunology le 31/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2023
• Auteurs : Pierre AmarencoPhilippa LavalléeJong KimJong KimJulien LabreucheHugo CharlesMaurice GiroudByung-Chul LeeMarie-Hélène MahagneElena MeseguerNorbert NighoghossianPhilippe Gabriel StegÉric VicautÉric BruckertPierre-Jean TouboulDidier LeysYannick BéjotFernando PicoEmmanuel TouzéGregory DucrocqJérémy AbtanOlivier VarennePierre-Jean TouboulAgnes KemmelFausta SyanaManele LedraTharani NagasaraMervette LedjeroudBahous SamiaHafirassou HadiaBenyoub HazareIkrame El JaghouniNessima YellesSofia ZemouriMervette LadjeroudSalim KeraiYunjeong InCristina HobeanuCeline GuidouxLucie CabrejoBertrand LapergueCandice SabbenJaime Gonzalez-ValcarcelRicardo RigualGaia SirimarcoAnna Martin-BechetElena ViedmaIoan AvramYves SamsonCharlotte RossoSophie CrozierSara LederAnne LégerSandrine DeltourGurkan MutluMarion YgerChiara ZavanoneFlore BaronnetChristine PiresBertrand LapergueAdrien WangSerge EvrardMaya TchikviladzeFrédéric BourdainDelphine LopezFernando PicoLaetitia Bayon de la TourMarie-Laure ChadenatDuc Long DuongSolène GentyCatherine HirelGurkan MutluChantal NifleJérôme ServanDaniela StanciuVeronica SudacevschiFazia Mélissa TirAnne-Cécile TroussièreJennifer YeungAnne-Céline ZeghoudiIkram Tidafi-BayouSylvain LachaudTae-Hee ChoLaura MechtouffThomas RitzenthallerLaurent DerexCarlo AlbanesiElodie OngAmandine BenoitNadia BerhouneSandra FelixMaud Esteban-MaderIgor SibonAnnabelle KazadiFrançois RouanetPauline RenouSabrina DebruxellesMathilde PoliSharmila SagnierJean-Louis MasValérie DomigoCatherine LamyEric BodiguelJérôme GrimaudValentin BohotinMichael ObadiaCandice SabbenErwan MorvanGilles RodierWilfried VadotHilde HénonCharlotte CordonnierFrédéric DumontMarie BodenantChristian LucasSolène MoulinNelly DequatreSonia AlamowitchJean-Paul MuresanThomas DrouetMagalie GalleaMarie-Amélie DallozStephen DelormeMarion YgerYannick BéjotPhilippe LoiselCarine BonninVirginie BernigalGuy Victor OssebyMarie Hervieu-BèguemarsacPierre GarnierSandrine AccassatMagali EpinatJérôme VarvatDoïna MarinescuAude Triquenot-BaganOzlem Ozkul- WermesterFrédéric PhilippeauAngel OlaruAnne VieillartAnnie LannuzelAlice DemolyValérie WolffMihaela DiaconuMarc BataillardFrancisco Macian MontoroFrédéric FaugerasLaeticia GimenezFrançoise Abdallah-LebeauSerge TimsitIrina Viakhireva-DovganyukAnne Tirel-BadetsFrançois-Mathias MerrienPhilippe GoasFrançois RouhartAurore JourdainBenoit GuillonFanny HérisssonMathieu Sevin-AllouetNathalie NasrJean Marc OlivotAlderic LecluseGuillaume MarcEmmanuel TouzéVincent de la SayetteMarion ApoilLi LinJulien CogezSophie GuettierOlivier GodefroyChantal LamyJean-Marc BugnicourtGrégory TaurinMarc MérienneJulien GereAnne-Marie ChessakTarik HabetAnna FerrierNathalie BourgoisDominique MinierMarie Caillier-MinierFabienne Contégal- CallierPhilippe VionYvan VaschaldeMohammed El AmraniMathieu ZuberMarie BruandetClaire Join- LambertPierre-Yves GarciaIsabelle SerreJean-Marc FaucheuxFatia RadjiElena Leca-RaduThomas DebrouckerRodica CumurcucSerkan CakmakStéphane PeyssonEmmanuel ElliePatricia BernadyThierry MoulinPaola MontielEugeniu RevencoPierre DecavelElisabeth MedeirosMyriam BouveretPierre LouchartClaudia VaduvaGrégory CouvreurEric SartoriAlnajar CarpentierMichèle LevasseurPierre LouchartJean-Marc FaucheuxPhilippe NeauXavier VandammeIsabelle MeresseMarc BataillardCanan OzsancakKatell BeauvaisPascal AuzouJoséphine AmevigbeFrancis VuillemetMarie-Hélène Dugay-ArentzGabriela CarelliMikel MartinezMarcel Maillet-VioudJean-Pierre EscaillasStéphane ChapuisJean TardyEric ManchonOlivier VarnetYong-Jae KimYoonkyung ChangTae-Jin SongJong Sung KimJung-Hoon HanKyung Chul NohEun-Jae LeeDong-Wha KangSun Uck KwonBoseoung KwonSeongho ParkDongwhane LeeHyuk Sung KwonDaeun JeongMinhwan LeeJoonggoo KimHanbin LeeHyo Jung NamSang Hun LeeBum Joon KimJae-Kwan ChaDaehyun KimRae Young KimSang Wuk SohnDong-Hyun ShimHyungjin LeeHyun-Wook NahSang Min SungKyung Bok LeeJeong Yoon LeeJee Eun YoonEung-Gyu KimJung Hwa SeoYong-Won KimYangha HwangMan Seok ParkJoon-Tae KimKang-Ho ChoiHyo Suk NamJi Hoe HeoYoung Dae KimIn Gun HwangHyung Jong ParkKyoung Sub KimJang Hyun BaekDong Beom SongJoon Sang YooJong-Moo ParkOhyun KwonWoong-Woo LeeJung-Ju LeeKyusik KangByung Kun KimJae-Sung LimMi Sun OhKyung-Ho YuBora HongMihoon JangSeyoung JangJung Eun JinJei KimHye Seon JeongKeun Sik HongHong Kyun ParkYong Jin ChoOh Young BangWoo-Keun SeoJongwon Chung
• Organismes : Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Laboratoire de Recherche Vasculaire Translationnelle Laboratoire de Recherche Vasculaire Translationnelle CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559
• Publié dans Stroke le 31/10/2020

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Résumé : BACKGROUND: Whether a strategy to target an LDL (low-density lipoprotein) cholesterol <70 mg/dL is more effective when LDL is reduced >50% from baseline rather than <50% from baseline has not been investigated. METHODS: The Treat Stroke to Target trial was conducted in France and South Korea in 61 sites between March 2010 and December 2018. Patients with ischemic stroke in the previous 3 months or transient ischemic attack within the previous 15 days and evidence of cerebrovascular or coronary artery atherosclerosis were randomly assigned to a target LDL cholesterol of <70 mg/dL or 100±10 mg/dL, using statin and/or ezetimibe as needed. We used the results of repeated LDL measurements (median, 5 [2–6] per patient) during 3.9 years (interquartile range, 2.1–6.8) of follow-up. The primary outcome was the composite of ischemic stroke, myocardial infarction, new symptoms requiring urgent coronary or carotid revascularization, and vascular death. Cox regression model including lipid-lowering therapy as a time-varying variable, after adjustment for randomization strategy, age, sex, index event (stroke or transient ischemic attack), and time since the index event. RESULTS: Among 2860 patients enrolled, patients in the lower target group who had >50% LDL cholesterol reduction from baseline during the trial had a higher baseline LDL cholesterol and a lower LDL cholesterol achieved as compared to patients who had <50% LDL cholesterol reduction (155±32 and 62 mg/dL versus 121±34 and 74 mg/dL, respectively, P <0.001 for both). In the <70 mg/dL target group, patients with >50% LDL reduction had a significant reduction in the primary outcome as compared to the higher target group (hazard ratio, 0.61 [95% CI, 0.43–0.88]; P =0.007) and patients with <50% LDL reduction from baseline had little reduction (hazard ratio, 0.96 [95% CI, 0.73–1.26]; P =0.75). CONCLUSIONS: In this post hoc analysis of the TST trial, targeting an LDL cholesterol of <70 mg/dL reduced the risk of primary outcome compared with 100±10 mg/dL provided LDL cholesterol reduction from baseline was superior to 50%, thereby suggesting that the magnitude of LDL cholesterol reduction was as important to consider as the target level to achieve. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01252875. URL: https://clinicaltrialsregister.eu ; Unique identifier: EUDRACT2009-A01280-57.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2023
• Auteurs : Florian Plaza OñateCélia ChamignonSebastian BurzNicolas N. LapaqueMagali MonnoyeCatherine PhilippeMaxime BredelLaurent ChêneWilliam FarinJean-Michel PaillarseJérome BoursierVlad RatziuPierre-Yves MoussetJoel DorePhilippe GerardHervé M. Blottiere
• Organismes : MICrobiologie de l'ALImentation au Service de la Santé Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques Centre de Recherche des Cordeliers MetaGenoPolis MICrobiologie de l'ALImentation au Service de la Santé MICrobiologie de l'ALImentation au Service de la Santé Physiopathologie des Adaptations Nutritionnelles
• Publié dans International Journal of Molecular Sciences le 03/05/2024

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Résumé : Non-alcoholic fatty liver disease (NAFLD) affects about 20–40% of the adult population in high-income countries and is now a leading indication for liver transplantation and can lead to hepatocellular carcinoma. The link between gut microbiota dysbiosis and NAFLD is now clearly established. Through analyses of the gut microbiota with shotgun metagenomics, we observe that compared to healthy controls, Adlercreutzia equolifaciens is depleted in patients with liver diseases such as NAFLD. Its abundance also decreases as the disease progresses and eventually disappears in the last stages indicating a strong association with disease severity. Moreover, we show that A. equolifaciens possesses anti-inflammatory properties, both in vitro and in vivo in a humanized mouse model of NAFLD. Therefore, our results demonstrate a link between NAFLD and the severity of liver disease and the presence of A. equolifaciens and its anti-inflammatory actions. Counterbalancing dysbiosis with this bacterium may be a promising live biotherapeutic strategy for liver diseases.

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Fichiers liés : ijms-24-12232-v2.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2023
• Auteurs : Marina WainsteinNicholas SpyrisonDanyang DaiMoji GhadimiJonathan Chávez-IñiguezLilia Rizo-TopeteBarbara Wanjiru CitarellaLaura MersonJason PoleRolando Claure-del GranadoDavid JohnsonSally ShrapnelHeryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelAmal AbrousLara AbsilAndrew AckerShingo AdachiDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalChika AkwaniEman Al QasimRazi AlalqamAngela AlbertiTala Al-DabbousSenthilkumar AlegesanMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouJoão AlvesRita AlvesJoão Melo AlvesJoana Alves CabritaMaria AmaralNur AmiraPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalAngel AsensioMuhammad AshrafJean Baptiste AssieAmirul AsyrafMinahel AtifAnika AtiqueJohann AuchabieHugues AumaitreAdrien AuvetLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrJ. 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OngJee Yan OngWilna OosthuyzenAnne OpavskyPeter OpenshawClaudia Milena Orozco-ChamorroJamel OrtolevaJavier OsatnikLinda O'SheaMiriam O'SullivanSiti Zubaidah OthmanNadia OuamaraRachida OuissaEric OziolMaïder PagadoyJustine PagesMassimo PalmariniGiovanna PanarelloPrasan Kumar PandaLai Hui PangMauro PanigadaNathalie PansuAurélie PapadopoulosRachael ParkeJérémie PasquierBruno PasteneFabian PataunerMohan Dass PathmanathanPatricia PatricioJuliette PatrierLisa PattersonMical PaulChristelle PaulJorge PaulosWilliam PaxtonJean-François PayenSandra PeakeKalaiarasu PeariasamyMiguel Pedrera JiménezGiles PeekFlorent PeelmanNathan Peiffer-SmadjaVincent PeigneMare PejkovskaPaolo PelosiIthan PeltanRui PereiraDaniel PerezLuis PerielThomas PerpointAntonio PesentiVincent PestreLenka PetrouMichele PetrovicVentzislava Petrov-SanchezFrank Olav PettersenGilles PeytavinScott PharandMichael PiagnerelliWalter PicardOlivier PiconeCarola PierobonDjura PiersmaCarlos PimentelValentine PiquardCatarina PiresIsabelle PironneauLionel PirothAyodhia PitalokaChiara PiubelliRiinu PiusLaurent PlantierHon Shen PngJulien PoissyRyadh PokeerbuxSergio PoliGeorgios PollakisDiane PonscarmeDiego Bastos PortoAndra-Maris PostDouwe PostmaPedro PovoaDiana PóvoasJeff PowisSofia PrapaSébastien PréauChristian PrebensenJean-Charles PreiserAnton PrinssenLucia ProençaSravya PudotaOriane PuéchalBambang Pujo SemediGregory PurcellLuisa QuesadaVíctor Quirós GonzálezElse Quist-PaulsenMohammed QuraishiFadi QutishatChristian RabaudAldo RafaelMarie RafiqMutia RahardjaniAmir Kamel RahimiRozanah Abd RahmanAhmad Kashfi Haji Ab RahmanFernando RainieriGiri Shan RajahramNagarajan RamakrishnanJosé RamalhoAhmad Afiq RamliBlandine RammaertGrazielle Viana RamosRitika RanjanChristophe RappMenaldi RasminIndrek RätsepTharmini RaviAndre RealStanislas RebaudetSarah RedlBrenda ReeveLiadain ReidDag Henrik ReikvamRenato ReisMartine RemyHongru RenAnne-Sophie ResseguierMatthieu RevestOleksa RewaTiago ReyesLuis Felipe ReyesMaria Ines RibeiroDavid RichardsonDenise RichardsonLaurent RichierSiti Nurul Atikah Ahmad RidzuanAna RiosAsgar RishuPatrick RispalKarine RissoNicholas RizerChiara RobbaAndré RobertoStephanie RobertsDavid RobertsonOlivier RobineauFerran Roche-CampoPaola RodariSimão RodeiaBernhard RoesslerPierre-Marie RogerAmanda RojekJuliette RomaruRoberto Roncon-AlbuquerqueMélanie RorizManuel Rosa-CalatravaMichael RoseDorothea RosenbergerAndrea RossaneseMatteo RossettiBénédicte RossignolPatrick RossignolStella RoussetCarine RoyBenoît RozeClark RussellMaria RyanMaeve RyanSteffi RyckaertAleksander Rygh HoltenIsabela SabaMusharaf SadatValla SahraeiMaximilien Saint-GillesPranya SakiyalakLeonardo SalazarGabriele SalesStéphane SallaberryCharlotte Salmon GandonniereHélène SalvatorEmely SanchezOlivier SanchezAngel Sanchez-MirallesVanessa Sancho-ShimizuGyan SandhuZulfiqar SandhuPierre-François SandrineOana SandulescuMarlene SantosShirley Sarfo-MensahIam Claire E. SarmientoBenjamine SartonSree SatyapriyaRumaisah SatyawatiEgle SaviciuteYen Tsen SawJustin SchafferTjard SchermerArnaud ScherpereelMarion SchneiderStephan SchrollMichael SchwameisJanet ScottJames Scott-BrownNicholas SedillotTamara SeitzMageswari SelvarajooCaroline SemailleMalcolm SempleRasidah Bt SenianEric SennevilleClaudia SepulvedaFilipa SequeiraTânia SequeiraAry Serpa NetoPablo Serrano BalazoteEllen ShadowitzSyamin Asyraf ShahidanMohammad ShamsahAnuraj ShankarShaikh SharjeelPratima SharmaCatherine ShawVictoria ShawJohn Robert SheenanHaixia ShiNobuaki ShimeHiroaki ShimizuKeiki ShimizuSally ShrapnelHoi Ping ShumNassima Si MohammedNg Yong SiangJeanne SibiudeAtif SiddiquiLouise SigfridPiret SillaotsCatarina SilvaRogério SilvaMaria Joao SilvaBenedict Sim Lim HengWai Ching SinPunam SinghBudha Charan SinghPompini Agustina SitompulKarisha SivamVegard SkogenSue SmithBenjamin SmoodCoilin SmythMichelle SmythMorgane SnackenDominic SoTze Vee SohJoshua SolomonTom SolomonEmily SomersAgnès SommetRima SongMyung Jin SongTae SongJack Song ChiaAlbert SottoEdouard SoumMarta SousaAna Chora SousaMaria Sousa UvaVicente Souza-DantasAlexandra SperryElisabetta SpinuzzaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherTrude SteinsvikYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelAnca Streinu-CercelAmi StuartDavid StuartRicha SuDecy SubektiGabriel SuenJacky SuenPrasanth SukumarAsfia SultanaCharlotte SummersDubravka SupicDeepashankari SuppiahMagdalena SurovcováSarah SyahrinKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziFabio TacconeLysa TaghersetShahdattul Mawarni TaibSara TalebJelmer TalsmaMaria Lawrensia TampubolonKim Keat TanYan Chyi TanHiroyuki TanakaTaku TanakaHayato TaniguchiCoralie TardivonPierre TattevinM Azhari TaufikHassan TawfikRichard TedderTze Yuan TeeJoão TeixeiraMarie-Capucine TellierSze Kye TeohVanessa TeotonioFrançois TéouléPleun TerpstraOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAlif Adlan Mohd ThabitZhang Duan ThamSuvintheran ThangaveluElmi TheronV. ThibaultSimon-Djamel ThibervilleBenoît ThillJananee ThirumanickamShaun ThompsonDavid ThomsonEmma ThomsonMathew ThorpeSurain Raaj Thanga ThuraiRyan ThwaitesPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitNoémie TissotFiona ToalJordan Zhien Yang TohMaria TokiKristian TonbySia Loong TonniiMarta TorreAntoni TorresHernando Torres-ZevallosMichael TowersTony TrapaniCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteAlexis TurgeonJean-Marie TurmelLance C.W. TurtleAnders TveitaPawel TwardowskiAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsLuís Val-FloresAmélie ValranStijn van de VeldeMarcel van den BergeJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van der WerfLaura van GulikJarne van HattemCarolien van NettenIlonka van VeenNoémie VanelHenk VanoverscheldePooja VargheseMichael VarroneShoban Raj VasudayanCharline VauchyShaminee VeeranAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJosé Ernesto VidalCésar VieiraJoy Ann VillanuevaAndrea VilloldoBenoit VisseauxChiara VitielloHarald VonkemanFanny VuottoNoor Hidayu WahabSuhaila Abdul WahabNadirah Abdul WahidMarina WainsteinLaura WalshChih-Hsien WangSteve WebbJia WeiTan Pei WenSanne WesseliusMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSue WillemsBailey WilliamsVirginie WilliamsPatricia WilliamsEvert-Jan WilsJessica WittmanCalvin WongXin Ci WongYew Sing WongTeck Fung WongGan Ee XianLim Saio XianPei Xuan KuanIoannis XynogalasSiti Rohani Binti Mohd YakopMasaki YamazakiElizabeth YaradYazdan YazdanpanahNicholas Yee Liang HingCécile YelnikChian Hui YeohStephanie YerkovichToshiki YokoyamaHodane YonisObada YousifAkram ZaaqoqMarion ZabbeMasliza ZahidMaram ZahranNor Zaila Binti ZaidanMaria ZambonMiguel ZambranoAlberto ZanellaNurul ZaynahHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : CIC - HEGP CIC Cochin Pasteur Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail
• Publié dans Kidney International Reports le 26/10/2020

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Fichiers liés : PIIS2468024923013104.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 31/07/2023
• Auteurs : Jean-Philippe ViseuEric YiouPierre-Olivier MorinAgnès Olivier
• Organismes : Complexité, Innovation, Activités Motrices et Sportives Complexité, Innovation, Activités Motrices et Sportives Institut de la Vision Complexité, Innovation, Activités Motrices et Sportives Institut Français du Cheval et de l'Equitation [Saumur]
• Publié dans Frontiers in Human Neuroscience le 31/10/2020

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Résumé : Introduction Compared to judokas (JU) and non-athletes (NA), horseback riders (HR) may develop specific changes in their sensory control of balance. Methods Thirty-four international-level JU, twenty-seven international-level HR and twenty-one NA participated. Participants stood upright on a plateform (static condition) or on a seesaw device with an instability along the mediolateral (ML) or the anteroposterior (AP) direction (dynamic conditions). These conditions were carried out with eyes opened (EO) or closed (EC), and with (wF) or without a foam (nF). Experimental variables included conventional (linear), non-linear center-of-pressure (COP) parameters, Romberg Quotient (RQ) and Plantar Quotient (PQ). Results Group effects. COP Surface (COPS) and standard deviation of COP along AP (SDY) were lower in HR than in JU in Static. SD Y was lower in HR than in JU in Dynamic AP. COP velocity (COPV) was lower in both HR and JU than in NA in Static and Dynamic. Sample entropy along AP and ML (SampEnY and SampEnX) were higher in HR than in JU in Static. SampEnY was higher in HR than in JU in Dynamic ML. Sensory effects. In EC, COPV was lower in JU than in NA in Dynamic AP, and lower in JU than in both HR and NA in Dynamic ML. In EO, COPV was lower in both JU and HR than in NA in Dynamic ML. RQ applied to COPS was lower in JU than in both HR and NA in Dynamic AP, and lower in JU than in HR in Dynamic ML. RQ applied to COPV was lower in JU than in both HR and NA in Static and Dynamic. PQ applied to COPS was higher in JU than in both HR and NA in Dynamic ML. Conclusion Results showed that the effects of sport expertise on postural control could only be revealed with specific COP variables and were directionally oriented and sport-dependant. HR seem to rely more on vision than JU, thus revealing that the contribution of the sensory inputs to balance control is also sport-dependent. Results open up new knowledge on the specificity of sport practice on multisensory balance information during upright posture.

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• Type de publi. : Article dans une revue
• Date de publi. : 29/07/2023
• Auteurs : Yunsong LiuJean-Daniel ParisMihalis VrekoussisPierre-Yves QuéhéMaximilien DesservettazJonilda KushtaFlorence DubartDemetris DemetriouPhilippe BousquetJean Sciare
• Organismes : Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ICOS-RAMCES Climate and Atmosphere Research Centre [Nicosia] Climate and Atmosphere Research Centre [Nicosia] Climate and Atmosphere Research Centre [Nicosia] Climate and Atmosphere Research Centre [Nicosia] Climate and Atmosphere Research Centre [Nicosia] Climate and Atmosphere Research Centre [Nicosia] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation INVerse pour les mesures atmosphériques et SATellitaires Climate and Atmosphere Research Centre [Nicosia]
• Publié dans Science of the Total Environment le 29/10/2020

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Résumé : Reconciling top-down and bottom-up country-level greenhouse gas emission estimates remains a key challenge in the MRV (Monitoring, Reporting, Verification) paradigm. Here we propose to independently quantify cumulative emissions from a significant number of methane (CH 4) emitters at national level and derive robust constraints for the national inventory. Methane emissions in Cyprus, an insular country, stem primarily from waste and agricultural activities. We performed 24 intensive survey days of mobile measurements of CH 4 from October 2020 to September 2021 at emission 'hotspots' in Cyprus accounting together for about 28 % of national CH 4 emissions. The surveyed areas include a large active landfill (Koshi, 8 % of total emissions), a large closed landfill (Kotsiatis, 18 %), and a concentrated cattle farm area (Aradippou, 2 %). Emission rates for each site were estimated using repeated downwind transects and a Gaussian plume dispersion model. The calculated methane emissions from landfills of Koshi and Kotsiatis (25.9 ± 6.4 Gg yr − 1) and enteric fermentation of cattle (10.4 ± 4.4 Gg yr − 1) were about 129 % and 40 % larger, respectively than the bottom-up sectorial annual estimates used in the national UNFCCC inventory. The parametrization of the Gaussian plume model dominates the uncertainty in our method, with a typical 21 % uncertainty. Seasonal variations have little influence on the results. We show that using an ensemble of in situ measurements targeting representative methane emission hotspots with consistent temporal and spatial coverage can contribute to the monitoring and validation of national bottom-up emission inventories.

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Fichiers liés : 1-s2.0-S0048969723045217-main.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/07/2023
• Auteurs : Rafael Alves BatistaAurélien Benoit-LévyTeresa BisterMauricio BustamanteYiren ChenLingmei ChengSimon ChicheJean-Marc ColleyPablo CorreaNicoleta Cucu LaurenciuZigao DaiBeatriz de ErricoSijbrand de JongJoão R.T de Mello NetoKrijn D de VriesPeter B DentonValentin DeocoeneKaikai DuanBohao DuanRalph EngelYizhong FanArsène FerrièreQuanbu GouJunhua GuMarion GuelfandJianhua GuoYiqing GuoVaidhai GuptaClaire GuépinLukas GülzowAndreas HaungsHaoning HeEric HivonHongbo HuXiaoyuan HuangYan HuangTim HuegeWen JiangRamesh KoiralaKumiko KoteraJelena KöhlerBruno L LagoSandra Le CozFrançois LegrandAntonios LeisosRui LiCheng LiuRuoyu LiuWei LiuPengxiong MaOscar MaciasFrédéric MagnardOlivier Martineau-HuynhAnanstasiia MikhnoPragati MitraMiguel MostafáFabrice MottezJean MouetteKohta MuraseValentin NiessStavros NonisShoichi OgioFoteini OikonomouTanguy PierogLech Wiktor PiotrowskiPierre PoisvertSimon PrunetXiangli QianMarkus RothTakashi SakoHarm SchoorlemmerBart SteemanDániel Szálas-MotesiczkySzymon SławińskiAnne TimmermansCharles TimmermansApostolos TsirigotisMatías TuerosShen WangXiangyu WangXu WangDaming WeiFeng WeiXiangping WuXuefeng WuXin XuXing XuLili YangXuan YangQiang YuanPhilippe ZarkaHoudun ZengChao ZhangJianli ZhangKewen ZhangPengfei ZhangSongbo ZhangHao Zhou
• Organismes : Laboratoire Intelligence Artificielle de Confiance pour l’Instrumentation (CEA, LIST) Institut d'Astrophysique de Paris Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de physique subatomique et des technologies associées Laboratoire Intelligence Artificielle de Confiance pour l’Instrumentation (CEA, LIST) Laboratoire de Physique Nucléaire et de Hautes Énergies Institut d'Astrophysique de Paris Laboratoire Univers et Particules de Montpellier Institut d'Astrophysique de Paris Institut d'Astrophysique de Paris Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Institut d'Astrophysique de Paris Laboratoire de Physique Nucléaire et de Hautes Énergies Institut d'Astrophysique de Paris Institut d'Astrophysique de Paris Laboratoire Univers et Théories Institut d'Astrophysique de Paris Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Joseph Louis LAGRANGE Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics

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Résumé : The Giant Radio Array for Neutrino Detection (GRAND) is an envisioned observatory of ultra-high-energy particles of cosmic origin, with energies in excess of 100 PeV. GRAND uses large surface arrays of autonomous radio-detection units to look for the radio emission from extensive air showers that are triggered by the interaction of ultra-high-energy cosmic rays, gamma rays, and neutrinos in the atmosphere or underground. In particular, for ultra-high-energy neutrinos, the future final phase of GRAND aims to be sensitive enough to discover them in spite of their plausibly tiny flux. Presently, three prototype GRAND radio arrays are in operation: GRANDProto300, in China, GRAND@Auger, in Argentina, and GRAND@Nancay, in France. Their goals are to field-test the design of the radio-detection units, understand the radio background to which they are exposed, and develop tools for diagnostic, data gathering, and data analysis. This list of contributions to the 38th International Cosmic Ray Conference (ICRC 2023) presents an overview of GRAND, in its present and future incarnations, and a look at the first data collected by GRANDProto13, the first phase of GRANDProto300.

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