Philippe JEAN-PIERRE
Professeur des universités en sciences de gestion
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Search for dark matter produced in association with a dark Higgs boson decaying into a bottom quark-antiquark pair in proton-proton collisions at $\sqrt{s}$ = 13 TeV
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 05/05/2026
- Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanJochen SchieckRobert SchöfbeckMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadArchana SharmaLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutDavid MarckxKirill SkovpenAdina Maria TomaruNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekHenriette Aarup PetersenSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereFrancisco Gameiro CasalinhoAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselDiego Matos FigueiredoThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar 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ReichertPrafulla SahaSevil SalurSteve SchnetzerSunil SomalwarRobert StoneSteffie Ann ThayilScott ThomasJay VoraDaniel AllyAndrés G DelannoySara FiorendiJesse HarrisTova HolmesAnkush Reddy KanugantiNimmitha KarunarathnaJohn LawlessLawrence LeeEmery NibigiraBrandi SkipworthStefan SpanierDevin AebiMuhammad AhmadTowsifa AkhterKonstantin AndrosovAashwin BasnetArtem BolshovOthmane BouhaliAntimo CagnottaValeria d'AmanteRicardo EusebiPatrick FlanaganJason GilmoreYumeng GuoTeruki KamonSifu LuoRyan MuellerAlexei SafonovNural AkchurinJordan DamgovYongbin FengNiramay GogateWeijie JinYelbir KazhykarimKamal LamichhaneSung Won LeeChristopher MadridAaron MankelTimo PeltolaIgor VolobouevEric AppeltYi ChenSenta GreeneAlfredo GurrolaWillard JohnsRaghav Kunnawalkam ElayavalliAndrew MeloDenis RathjensFrancesco RomeoPaul SheldonShengquan TuoJulia VelkovskaJussi ViinikainenJingyu ZhangBryan CardwellHeewon ChungBradley CoxJohn HakalaGabriela Hamilton Ilha MachadoRobert HiroskyMaria JoseAlexander LedovskoyCristina MantillaChristopher NeuClara Ramón ÁlvarezZhenyu WuSaptaparna BhattacharyaPaul Edmund KarchinAnagha AravindSunanda BanerjeeKevin BlackTulika BoseElise ChavezSridhara DasuPieter EveraertsCamilla GalloniHe HeMatthew HerndonAlain HerveCharis Kleio KorakaShivani LomteRichard LovelessAbhishikth MallampalliAbdollah MohammadiSusmita MondalTrevor NelsonGanesh ParidaLaurent PétréDeborah PinnaAlexander SavinVictor ShangVarun SharmaWesley H SmithDylan TeagueHo Fung TsoiWren VetensAbigail WardenSerguei AfanasievVadim AlexakhinYuri AndreevTagir AushevDzmitry BudkouskiRuslan ChistovMikhail DanilovTatyana DimovaAlexander ErshovSergei GninenkoIlya GorbunovAndrey GribushinAlexey KamenevVladimir KarjavineMikhail KirsanovVyacheslav KlyukhinOlga KodolovaVladimir KorenkovIurii KorsakovAleksei KozyrevNikolai KrasnikovAlexander LanevAlexander MalakhovViktor MatveevAlexander NikitenkoVladimir PalichikVictor PerelyginSergey PetrushankoOlesia RadchenkoMaria SavinaVladislav ShalaevSergey ShmatovSiarhei ShulhaYuri SkovpenKirill SlizhevskiyVitaly SmirnovOleg TeryaevIrina TlisovaAlexander ToropinNikolay VoytishinAnatoli ZarubinIlia ZhizhinLev DudkoVictor KimVictor MurzinVadim OreshkinDmitry SosnovEdouard BoosViacheslav BunichevMikhail DubininViktor SavrinAlexander Snigirev
Search for dark matter produced in association with a dark Higgs boson decaying into a bottom quark-antiquark pair in proton-proton collisions at $\sqrt{s}$ = 13 TeV
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 05/05/2026
- Auteurs : Aram HayrapetyanVladimir MakarenkoArmen TumasyanWolfgang AdamLisa BenatoThomas BergauerMarko DragicevicCristina GiordanoPriya Sajid HussainManfred JeitlerNatascha KrammerAng LiDietrich LikoMark MatthewmanJochen SchieckRobert SchöfbeckMaryam ShooshtariMangesh SonawaneWolfgang WaltenbergerClaudia-Elisabeth WulzTahys JanssenHyejin KwonDaniel Ocampo HenaoThomas van LaerPierre van MechelenJas BierkensNordin BreugelmansJorgen d'HondtSoumya DansanaAlexandre de MoorMartin DelcourtFelix HeyenYanwen HongPavlo KashkoSteven LowetteInna MakarenkoDenise MüllerJuhee SongStefaan TavernierMichael TytgatGerrit Patrick van OnsemSenne van PutteDavid VanneromBugra BilinBarbara ClerbauxAloke Kumar DasIsabelle de BruynGilles de LentdeckerHugues EvardLaurent FavartParaskevas GianneiosAli KhalilzadehFakhri Alam KhanAndrea MalaraMuhammad Aamir ShahzadArchana SharmaLaurent ThomasMax Vanden BemdenCatherine Vander VeldePascal VanlaerFengwangdong ZhangMaarten de CoenDidar DoburGul GokbulutDavid MarckxKirill SkovpenAdina Maria TomaruNiels van den BosscheJan van der LindenJules VandenbroeckLiam WezenbeekHenriette Aarup PetersenSamuel BeinAnna BeneckeAgni BethaniGiacomo BrunoAlessandra CappatiJerome de Favereau de JeneretChristophe DelaereFrancisco Gameiro CasalinhoAndrea GiammancoAhmet Oguz GuzelVincent LemaitreJindrich LidrychPaul MalekPaola MastrapasquaSemra TurkcaparGilvan AlvesMapse Barroso Ferreira FilhoEduardo CoelhoCarsten HenselDiego Matos FigueiredoThales Menezes de OliveiraClemencia Mora HerreraPatricia Rebello TelesMariana SoeiroEdmilson José Tonelli ManganoteAntonio Vilela PereiraWalter Luiz Aldá JúniorHelena Brandao MalbouissonWagner CarvalhoJose ChinellatoMatheus Costa ReisEliza Melo da CostaGustavo Gil da SilveiraDilson de Jesus DamiaoSandro Fonseca de SouzaRaphael Gomes de SouzaSilas JesusTulio Laux KuhnMatheus MacedoKevin Mota AmariloLuiz MundimHelio NogimaJoao Pedro PinheiroAlberto SantoroAndre SznajderMauricio ThielFelipe Torres da Silva de AraujoCesar Augusto BernardesLuigi CalligarisFlorian DamasThiago TomeiEduardo de Moraes GregoresBruno Lopes da CostaIsabela Maietto SilverioPedro G MercadanteSergio F NovaesSandra PadulaValerie ScheurerAleksandar AleksandrovGeorgy AntchevPetar DanevRoumyana HadjiiskaPlamen IaydjievMariana ShopovaGeorgi SultanovAnton DimitrovLeander LitovBorislav PavlovPeicho PetkovAnton PetrovSumit KeshriDavid Nicolas Laroze NavarreteShalini ThakurWilliam BrooksTongguang ChengTahir JavaidLong WangLi YuanZhen HuZhengchen LiangJinfeng LiuXining WangHeng YangGuo-Ming ChenHe-Sheng ChenMingshui ChenYe ChenQingfeng HouXiaonan HouFabio IemmiChun-Hua JiangHongbo LiaoGeliang LiuZhenan LiuJia-Ning SongShaowei SongJunquan TaoChu WangJin WangHuaqiao ZhangJingzhou ZhaoAntonis AgapitosYong BanAlexandra Carvalho Antunes de OliveiraSen DengBotao GuoQianying GuoChuqiao JiangAndrew LevinCongqiao LiQiang LiYajun MaoSitian QianSi-Jin QianXuelong QinClaudio QuarantaXiaohu SunDayong WangJin WangMingtao ZhangYuzhe ZhaoChen ZhouShuai YangZhengyun YouKhawla JaffelNan LuGerry BauerZhipeng CuiBolin LiHui WangKai YiJingqing ZhangYuji LiYilin ZhouZhen LinChenfeng LuMeng XiaoCarlos AvilaDiego Andres Barbosa TrujilloAndrés CabreraCarlos FlorezJorge FragaJose Antonio Reyes VegaCésar RendónManuel RodriguezAnderson Alexis Ruales BarbosaJosé David Ruiz AlvarezNikola GodinovicDamir LelasAna SculacMarko KovacAndro PetkovicToni SculacPedrame BargassaVuko BrigljevicBhakti Kanulal ChitrodaDinko FerencekKresimir JakovcicAndrei StarodumovTatjana SusaAlexandros AttikisKonstantinos ChristoforouSotiroulla KonstantinouChristos LeonidouLeonidas PaizanosFotios PtochosPanos A RazisHans RykaczewskiHalil SakaAnton StepennovMiroslav FingerMichael FingerEdy AyalaEdgar Carrera JarrinBasma El-MahdyShaaban KhalilAhmed HusseinHemida MohammedMario KadastikTorben LangeChristine NielsenJoosep PataMartti RaidalNorman SeebaLaurits TaniErik BrückenAnna MilievaKenneth OsterbergMikko VoutilainenFrancisco Ignacio Garcia FuentesPatin InkaewKimmo Tuomas Samuli KallonenRavindra Kumar VermaTapio LampénKati Lassila-PeriniBettina LehtelaSami LehtiTomas LindénNestor Raul Mancilla XintoMikael MyllymäkiMilla-Maarit RantanenSanteri SaariokariNico Timothy ToikkaJorma TuominiemiNurfikri Bin NorjoharuddeenHenning KirschenmannPanja-Riina LuukkaHenri PetrowMarc BesanconFabrice CoudercMarc DejardinDaniel DenegriPaul DevougeJean-Louis FaureFederico FerriPaul GaigneSerguei GanjourPhilippe GrasGautier Hamel de MonchenaultMintu KumarVictor LohezicYuliia MaidannykJulie MalclesFrancesco OrlandiLouis PortalesSamuele RonchiMehmet Özgür SahinAurore Savoy-NavarroPolina SimkinaMaksym TitovMarta TornagoRuth Amella RanzFlorian BeaudetteGiacomo BoldriniPhilippe BussonClaude CharlotMarco ChiusiTheo Damien CuissetOlivier DavignonAdinda de WitTrisha DebnathIsaac Telford EhleShamik GhoshAndrew GilbertRaphael Granier de CassagnacLida KalipolitiMartina ManoniMatthew NguyenStepan ObraztsovChristophe OchandoRoberto SalernoJean-Baptiste SauvanYves SiroisGamze 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Résumé : A search for dark matter produced in association with a dark Higgs boson decaying into a bottom quark-antiquark pair has been performed using proton-proton collision data at a center-of-mass energy of 13 TeV. The search uses data collected with the CMS detector at the CERN LHC during the 2016$-$2018 data-taking period, corresponding to an integrated luminosity of 138 fb$^{-1}$. The results are interpreted in terms of a theoretical model of dark matter production that, together with a spin-1 gauge boson mediator, predicts the existence of a Higgs-boson-like particle in the dark sector (i.e., a dark Higgs boson). This search focuses on an experimental signature with large missing transverse momentum from dark matter production and a resonant structure in the invariant mass of the bottom quark-antiquark pair from the dark Higgs boson decay. Upper limits at 95% confidence level on the signal strength for dark Higgs boson mass hypotheses below 160 GeV are set. Values of the mediator mass up to 4.5 (2.5) TeV are excluded at 95% confidence level for a dark Higgs boson mass of 50 (150) GeV. This represents the most stringent limits set to date for the dark Higgs boson masses considered in this study.
Source -
Study of $t\bar{t}$ threshold effects in $eμ$ differential distributions measured in $\sqrt{s}=13$ TeV $pp$ collisions with the ATLAS detector
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 04/05/2026
- Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczBobby Samir AcharyaAnke AckermannJona AckerschottClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatt AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiAmmara AhmadFaig AhmadovSonakshi AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatTorsten AkessonDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertUna Helena AlbertiPietro AlbicoccoSara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiCorentin AllaireBenedict AllbrookeDerrick AllenJonny AllenJulia Frances AllenCamron Stephen AlleyEarl Russel Tang AlmazanAlberto AloisioFrancisco AlonsoCristiano AlpigianiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiYara Do Amaral CoutinhoChristoph AmelungMaximilian AmerlThiziri AmezzaBaktash AminiKyle AmirieArtem AmirkhanovDimitra AmperiadouChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanMichaela ArampatziSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceMatteo ArcuriJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamJihad AssahsahKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham AtmaniPrachi AtmasiddhaKamil AugstenAdrien AuriolVolker Andreas AustrupArnav Sunil AvadGiuseppe AvolioAmir AzzamDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuErik BachmannMathias Josef BackesAnthony BadeaTamas Marton BaerMarzieh BahmaniDaniel BahnerKehang BaiLuke BainesKeith BakerDebottam Bakshi GuptaLuiz Eduardo Balabram FilhoVeena BalakrishnanRahul BalasubramanianPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasIsaac BamwidhiElzbieta BanasMarilena BandieramonteShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoMarten Zefanja BarelTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliAlan BarrJackson BarrFernando BarreiroJoao Barreiro Guimaraes da CostaMaura BarrosFalk BartelsRainer BartoldusAdam Edward BartonPavol BartosMarta Baselga BacarditSaleh BashiriAhmed BassalatMatthew Joseph BassoSusan BatajuRussell BateRichard BatesMarco BattagliaDaariimaa BattulgaMatteo BauceLukas BauckhagePatrick BauerLukas BayerTomas BazzanoTristan BeauJean Yves BeaucampStephanie BeauceronPierre-Hugues 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ZeitnitzHao ZengTodd ZengerTibor ZenisSeth ZenzWenxiao ZhanBowen ZhangDengfeng ZhangGengyuan ZhangJie ZhangJinlong ZhangLuxin ZhangLei ZhangPeng ZhangRui ZhangSijing ZhangYulei ZhangYuwen Ebony ZhangYangfan ZhangYixiang ZhangZhidong ZhangZihan ZhangZhirong ZhangZhuolin ZhangZhiqing Philippe ZhangHaoran ZhaoTongbin ZhaoYuzhan ZhaoZhengguo ZhaoZihan ZhaoAlexey ZhemchugovJinchao ZhengKai ZhengLu ZhengXiangxuan ZhengZhi ZhengDewen ZhongBing ZhouBai-Hong ZhouNing ZhouYan ZhouYong ZhouYou ZhouZhanhang ZhouJunjie ZhuXuliang ZhuYifan ZhuXuai ZhuangKonstantin ZhukovPanagiotis ZiakasNikolai ZimineJoachim ZinsserMichal ZiolkowskiLidija ZivkovicAntonio ZoccoliKnut ZochAngelos ZografosTheodore ZorbasLukasz Zwalinski
Study of $t\bar{t}$ threshold effects in $eμ$ differential distributions measured in $\sqrt{s}=13$ TeV $pp$ collisions with the ATLAS detector
- Type de publi. : Pré-publication, Document de travail
- Date de publi. : 04/05/2026
- Auteurs : Georges AadErlend AakvaagBraden Keim AbbottSara AbdelhameedKira AbelingNils Julius AbichtHaider AbidiMohammed AboelelaAsmaa AboulhormaHalina AbramowiczBobby Samir AcharyaAnke AckermannJona AckerschottClaire Adam BourdariosLeszek AdamczykSagar AddepalliMatt AddisonJahred AdelmanAytul AdiguzelTim AdyeTony AffolderYoav AfikMerve Nazlim AgarasAnamika AggarwalCatalin AgheorghieseiAmmara AhmadFaig AhmadovSonakshi AhujaXiaocong AiGiulio AielliArya AikotMalak Ait TamlihatTorsten AkessonDaiya AkiyamaNilima Nilesh AkolkarSina AktasGian Luigi AlberghiJustin AlbertUna Helena AlbertiPietro AlbicoccoSara AlderweireldtZackary Lee AlegriaMartin AleksaIgor AlexandrovCalin AlexaTheodoros AlexopoulosFabrizio AlfonsiMalte AlgrenMuhammad AlhroobBabar AliHanadi AliShahzad AliSamuel William AlibocusMalik AlievGianluca AlimontiCorentin AllaireBenedict AllbrookeDerrick AllenJonny AllenJulia Frances AllenCamron Stephen AlleyEarl Russel Tang AlmazanAlberto AloisioFrancisco AlonsoCristiano AlpigianiAdrian Alvarez FernandezMario Alves CardosoMariagrazia AlviggiYara Do Amaral CoutinhoChristoph AmelungMaximilian AmerlThiziri AmezzaBaktash AminiKyle AmirieArtem AmirkhanovDimitra AmperiadouChristos AnastopoulosTim AndeenJohn Kenneth AndersAdam Campbell AndersonAttilio AndreazzaStylianos AngelidakisAaron AngeramiAlexey AnisenkovAlberto AnnoviClaire AntelEgor AntipovMario AntonelliFabio AnulliMasato AokiTakumi AokiMarco AparoLudovica Aperio BellaMariano ApicellaChristian AppeltAram ApyanMichaela ArampatziSergio Javier Arbiol ValChiara ArcangelettiAyana Tamu ArceMatteo ArcuriJean-Francois ArguinSpyros ArgyropoulosJan-Hendrik ArlingOlivier ArnaezHannah ArnoldGiacomo ArtoniHaruka AsadaSiranush AsatryanNedaa Alexandra AsbahRachel Amy Ashby PickeringAsim Mohammed AslamJihad AssahsahKetevi Adikle AssamaganRobert AstalosSten AstrandRose AtashiRyan Justin AtkinHicham AtmaniPrachi AtmasiddhaKamil AugstenAdrien AuriolVolker Andreas AustrupArnav Sunil AvadGiuseppe AvolioAmir AzzamDominik BabalHenri BachacouKonstantinos BachasAlexander BachiuErik BachmannMathias Josef BackesAnthony BadeaTamas Marton BaerMarzieh BahmaniDaniel BahnerKehang BaiLuke BainesKeith BakerDebottam Bakshi GuptaLuiz Eduardo Balabram FilhoVeena BalakrishnanRahul BalasubramanianPetr BalekEric BallabeneFabrice BalliLisa Marie BaltesWilliam Keaton BalunasIsaac BamwidhiElzbieta BanasMarilena BandieramonteShubham BansalLiron BarakMarawan BarakatElisabetta BarberioDario BarberisMarlon Benoit BarberoMarten Zefanja BarelTeresa BarillariMartin BarisitsTim BarklowPetr BaronDiego BaronToni BaroncelliAlan BarrJackson BarrFernando BarreiroJoao Barreiro Guimaraes da CostaMaura BarrosFalk BartelsRainer BartoldusAdam Edward BartonPavol BartosMarta Baselga BacarditSaleh BashiriAhmed BassalatMatthew Joseph BassoSusan BatajuRussell BateRichard BatesMarco BattagliaDaariimaa BattulgaMatteo BauceLukas BauckhagePatrick BauerLukas BayerTomas BazzanoTristan BeauJean Yves BeaucampStephanie BeauceronPierre-Hugues 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Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Subatomique et de Cosmologie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie AstroParticule et Cosmologie Laboratoire des deux Infinis de Toulouse AstroParticule et Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Laboratoire de Physique de Clermont Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Subatomique et de Cosmologie Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique de Clermont Laboratoire de Physique Nucléaire et de Hautes Énergies Centre de Physique des Particules de Marseille Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Centre de Physique des Particules de Marseille Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Laboratoire d'Annecy de Physique des Particules Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Institut de Recherches sur les lois Fondamentales de l'Univers Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique de Clermont Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire des deux Infinis de Toulouse Centre de Physique des Particules de Marseille Centre de Physique des Particules de Marseille Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire des deux Infinis de Toulouse Laboratoire de Physique Nucléaire et de Hautes Énergies Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire de Physique Subatomique et de Cosmologie Centre de Physique des Particules de Marseille AstroParticule et Cosmologie Laboratoire de Physique des 2 Infinis Irène Joliot-Curie Laboratoire d'Annecy de Physique des Particules
Résumé : The recent ATLAS measurement of the normalised $eμ$ dilepton invariant mass and azimuthal angle distributions in $\sqrt{s}=13$ TeV $pp$ collisions at the Large Hadron Collider is extended to study the sensitivity to the formation of quasi-bound states near the $t\bar{t}$ threshold. The measured differential distributions are compared with $t\bar{t}$ models incorporating perturbative QCD predictions for the hard process, with or without the addition of colour-singlet quasi-bound states. The data are better described by the predictions incorporating quasi-bound-state formation. Fits to the dilepton invariant mass distribution show evidence for the latter process with an observed significance exceeding three standard deviations, and a measured cross-section in agreement with dedicated studies of the threshold region.
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Comparison of TRACIS campaign data with data from radiosonde, IPRAL Lidar and ERA5
- Type de publi. : Communication dans un congrès
- Date de publi. : 03/05/2026
- Auteurs : Alexis PoignardAntoine FarahAlain SarkissianPhilippe KeckhutDunya AlraddawiSergey KhaykinJean-Charles DupontJulie Capo
Comparison of TRACIS campaign data with data from radiosonde, IPRAL Lidar and ERA5
- Type de publi. : Communication dans un congrès
- Date de publi. : 03/05/2026
- Auteurs : Alexis PoignardAntoine FarahAlain SarkissianPhilippe KeckhutDunya AlraddawiSergey KhaykinJean-Charles DupontJulie Capo
- Organismes : ATMOSPHERE - LATMOS MeteoModem MeteoModem ATMOSPHERE - LATMOS ATMOSPHERE - LATMOS ATMOSPHERE - LATMOS ATMOSPHERE - LATMOS Institut Pierre-Simon-Laplace Centre national de recherches météorologiques
Résumé : The study of atmospheric composition is a major priority for improving the understanding of future climate models; therefore, it is essential to analyze in detail the variations of certain key variables, particularly water vapor, which strongly influences meteorological phenomena and plays a major role in radiative forcing. During my doctoral project, my research focused on studying the variability of water vapor using radiosoundings, an instrumental method for obtaining precise and high-quality measurements down to the UT/LS zone, by improving the quality of measurements through instrumentation. In addition to internal tests aimed at obtaining higher-quality measurements, setting up observation campaigns is a top priority in order to validate the performance of the sondes under real-world conditions, identify seasonal biases, and thus be able to make various corrections if necessary. Therefore, the TRACIS (Tropospheric Research Campaign on Air Moisture Content by Ipral at SIRTA) comparison campaign, in which I participated and which took place at the SIRTA site (Atmospheric Remote Sensing Research Instrumental Site) [48.71331°N, 2.20901°E] from May 12 to June 12, 2025, made it possible to assess the consistency of the data between the different sondes, while comparing these datasets with auxiliary sources such as ground-based observations and satellite measurements. This multi-source approach notably includes measurements from the IPRAL LiDAR, as well as fields from the ERA5 reanalysis model, thus strengthening the comparison, identifying potential systematic biases, and improving the overall interpretation of the results. Preliminary analyses focus on comparisons between the combined working measurement standard (CWS; mean RH M10/RS41) and other convergent datasets (M20, ERA5, and IPRAL LiDAR), allowing an evaluation of the representativeness and consistency of the different observation sources.
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Derivation and Validation of a COPD-specific Pulmonary Embolism Diagnostic Strategy
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Vicky MaiDavid JiménezDean FergussonOlivier SanchezRaquel MorilloPierre-Marie RoyCarmen RodriguezFrédéric GagnadouxPedro Ruiz-ArtachoJeannot SchmidtEva TaberneroLaurent BertolettiCécile TromeurPhilippe GirardRanjeeta MallickGrégoire Le GalFrancis Couturaud
Derivation and Validation of a COPD-specific Pulmonary Embolism Diagnostic Strategy
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Vicky MaiDavid JiménezDean FergussonOlivier SanchezRaquel MorilloPierre-Marie RoyCarmen RodriguezFrédéric GagnadouxPedro Ruiz-ArtachoJeannot SchmidtEva TaberneroLaurent BertolettiCécile TromeurPhilippe GirardRanjeeta MallickGrégoire Le GalFrancis Couturaud
- Organismes : Université d'Ottawa = University of Ottawa [Ontario] Ottawa Hospital Research Institute [Ottawa] Hospital Universitario Ramón y Cajal [Madrid] Université d'Ottawa = University of Ottawa [Ontario] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Hospital Universitario Ramón y Cajal [Madrid] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Universitaire d'Angers MitoVasc - Équipe CarME (Cardiovascular Pathophysiology) Institut de Recherche en Cancérologie de Montpellier MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Instituto Ramon y Cajal de Investigacion Sanitaria [Madrid, Spain] CHU Clermont-Ferrand Hospital de Cruces, Bilbao Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] U 1059 – SAINBIOSE Bio-ingénierie Service de Médecine vasculaire et thérapeutique [CHU de Saint-Etienne] Groupe d'Etude de la Thrombose de Bretagne Occidentale F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Institut Jacques Monod Ottawa Hospital Research Institute [Ottawa] F-Crin INvestigation Network On Venous Thrombo-Embolism [CHU Saint-Etienne] Centre Hospitalier Régional Universitaire de Brest
- Publié dans Thrombosis and Haemostasis le 22/10/2020
Résumé : Abstract Diagnosing pulmonary embolism (PE) in patients with chronic obstructive pulmonary disease (COPD) exacerbation is challenging due to similarities in clinical symptoms. The aim of this study was to evaluate predictors of PE and to derive and validate a COPD-specific PE diagnostic strategy. A post-hoc analysis of the PEP trial, a prospective multicenter study of patients with COPD hospitalized with acutely worsening respiratory symptoms, was conducted. The outcome predicted was PE at admission. Univariable and multivariable analyses were conducted to evaluate predictors of PE. Receiver operating characteristic curves were computed to determine the most discriminant D-dimer cut-offs. The COPD-specific PE diagnostic strategy was externally validated in the independent SLICE trial cohort. A total of 734 patients were included. At admission, the prevalence of PE and/or proximal deep venous thrombosis (DVT) was 6.5% (95%CI 5.0–8.6%). A COPD-specific PE diagnostic strategy consisting of a 3-item score (type of COPD exacerbation, alternative diagnosis less likely than PE, and clinical signs of DVT) combined with D-dimer at specific cut-offs (1,000 μg/L if 0 score item and 500 μg/L if 1 or 2 score items) was derived. The overall diagnostic failure rate was 0.9% (95%CI 0.4–1.9%) and 392 patients (53.4%) would need imaging to rule out PE. The external validation showed comparable results. A COPD-specific PE diagnostic strategy was derived specifically for patients with COPD and acutely worsening respiratory symptoms. Further prospective validation of this diagnostic algorithm is needed prior to integrating it in clinical practice.
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From non-specific biomarker to targeted action: transdiagnostic and sex-specific drivers of high-CRP status in severe mental illness across the FondaMental Advanced Centers of Expertise (FACE) cohorts
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Tim RietbergSusana BarbosaPieter MeysmanBruno AouizerateFrank BellivierFabrice BernaDelphine CapdevielleIsabelle Chereau-BoudetPhilippe CourtetClément DondéCaroline DubertretB EtainWissam El-HageMona GerentesJérôme HoltzmannEric FakraEmmanuel HaffenNoomane BouazizAntoine LefrèrePierre-Michel LlorcaJasmina MalletDavid MisdrahiÉmilie OliéAgnès PelletierGiulia PivaBaptiste PignonMircea PolosanRomain ReyPaul RouxLudovic SamalinFranck SchürhoffRaymund SchwanFlorian StéphanDavid SzekelyMathieu UrbachGuillaume VaivaEtienne VeryAntoine YrondiMarion LeboyerLivia de PickerOphélia Godin
From non-specific biomarker to targeted action: transdiagnostic and sex-specific drivers of high-CRP status in severe mental illness across the FondaMental Advanced Centers of Expertise (FACE) cohorts
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Tim RietbergSusana BarbosaPieter MeysmanBruno AouizerateFrank BellivierFabrice BernaDelphine CapdevielleIsabelle Chereau-BoudetPhilippe CourtetClément DondéCaroline DubertretB EtainWissam El-HageMona GerentesJérôme HoltzmannEric FakraEmmanuel HaffenNoomane BouazizAntoine LefrèrePierre-Michel LlorcaJasmina MalletDavid MisdrahiÉmilie OliéAgnès PelletierGiulia PivaBaptiste PignonMircea PolosanRomain ReyPaul RouxLudovic SamalinFranck SchürhoffRaymund SchwanFlorian StéphanDavid SzekelyMathieu UrbachGuillaume VaivaEtienne VeryAntoine YrondiMarion LeboyerLivia de PickerOphélia Godin
- Organismes : Universiteit Antwerpen = University of Antwerp Épidémiologie Sociale, Santé Mentale et Addictions [iPLesp] Sorbonne Université Universiteit Antwerpen = University of Antwerp Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] Hôpitaux Universitaires de Strasbourg Fédération de Médecine Translationnelle de Strasbourg Neuroscience et Psychiatrie Translationnelle de Strasbourg Fondation FondaMental [Créteil] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Université Clermont Auvergne Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Alpes-Isère [Grenoble] Fondation FondaMental [Créteil] Pôle Psychiatrie et Neurologie [Grenoble] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] AP-HP - Hôpital Louis Mourier Optimisation thérapeutique en Neuropsychopharmacologie GHU AP-HP Nord - Université Paris Cité Fondation FondaMental [Créteil] AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Imaging, Brain & Neuropsychiatry Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor Fondation FondaMental [Créteil] Pôle Psychiatrie et Neurologie [Grenoble] Fondation FondaMental [Créteil] Pôle Psychiatrie [CHU Saint-Etienne] Centre hospitalier Charles Perrens [Bordeaux] Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Laboratoire de recherches Intégratives en Neurosciences et psychologie Cognitive Université Marie et Louis Pasteur Fondation FondaMental [Créteil] Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Université Sorbonne Paris Nord Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier le Vinatier [Bron] Assistance Publique - Hôpitaux de Marseille Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Laboratoire Interdisciplinaire pour l'Innovation et la Recherche en Santé d’Orléans Centre Hospitalier Universitaire d'Orléans Fondation FondaMental [Créteil] Etablissement public de santé mentale du Loiret Georges Daumézon Université de Bordeaux Fondation FondaMental [Créteil] Institut de Neurosciences cognitives et intégratives d'Aquitaine Centre hospitalier Charles Perrens [Bordeaux] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor Fondation FondaMental [Créteil] Centre Hospitalier le Vinatier [Bron] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Université Claude Bernard Lyon 1 Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor IMRB - "Neuropsychiatrie translationnelle" [Créteil] Université Paris-Est Créteil Val-de-Marne - Faculté de médecine CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Fondation FondaMental [Créteil] [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Alpes-Isère [Grenoble] Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Centre Hospitalier de Versailles André Mignot Fondation FondaMental [Créteil] Centre de recherche en épidémiologie et santé des populations Fondation FondaMental [Créteil] Service Psychiatrie Adulte [CHU Clermont-Ferrand] Institut Pascal Fondation FondaMental [Créteil] Université Paris-Est Créteil Val-de-Marne - Paris 12 AP-HP - Hôpital Henri-Mondor IMRB - "NeuroPsychologie Interventionnelle" [Créteil] Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Imagerie Adaptative Diagnostique et Interventionnelle Soins Primaires, Santé Publique, Registre des cancers de Bretagne Occidentale Fondation FondaMental [Créteil] CHRU Brest - Psychiatrie Adulte Hôpital Princesse Grace [Monaco] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Centre de recherche en épidémiologie et santé des populations Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Fondation FondaMental [Créteil] Centre National de Ressources et de Résilience [Lille] Fondation FondaMental [Créteil] Service Psychiatrie, Psychothérapies et Art-thérapie [CHU Toulouse] Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs Toulouse NeuroImaging Center Service Psychiatrie et psychologie médicale [CHU Toulouse] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor Université Paris-Est Créteil Val-de-Marne - Faculté de médecine Universiteit Antwerpen = University of Antwerp Fondation FondaMental [Créteil] AP-HP - Hôpital Henri-Mondor IMRB - "Neuropsychiatrie translationnelle" [Créteil] Université Paris-Est Créteil Val-de-Marne - Faculté de médecine
- Publié dans Brain, Behavior, and Immunity le 29/10/2020
Résumé : Background and objectives: Low-grade systemic inflammation contributes to the pathophysiology of severe mental illness (SMI) in a substantial subset of patients, who often experience greater disease burden and poorer treatment response. Elevated C-reactive protein (CRP), defined as CRP ≥ 3 mg/L, has been proposed to identify this group, but its non-specificity limits the biomarker's ability to guide targeted intervention. We aimed to determine the most consistent drivers of high CRP across bipolar disorder (BD), schizophrenia (SZ) and major depressive disorder (MDD), and to translate these into clinically actionable intervention targets using robust data-driven methods. Methods: We pooled and harmonised data from three large French national SMI cohorts (n = 7149: 4797 bipolar disorder, 1958 schizophrenia and 394 resistant major depression) and classified participants by CRP ≥ 3 mg/L, as well as an alternative cut-off of 5 mg/L. We applied penalised logistic regression (PLR), random forests (RF) and unsupervised clustering, using 28 biopsychosocial variables to identify robust drivers of high-CRP status. We then grouped these into actionable targets and assessed relative dominance. Results: In total, 30.16% of participants had CRP ≥ 3 mg/L. PLR identified female sex (OR [95% CI]: 1.60 [1.27, 1.93]), higher BMI (OR: 1.09 [1.07, 1.13]), current nicotine dependence (OR: 1.05 [1.02, 1.09]), lower HDL cholesterol (OR: 0.57 [0.44, 0.73]) and smoking (ex-smoker status OR: 0.84 [0.66, 0.98]) as consistent drivers. RF highlighted a similar set of key drivers, also including waist circumference, triglycerides and cardiovascular comorbidities. Clustering of the high-CRP group was almost entirely driven by smoking status and nicotine dependence. When grouped into actionable targets, the identified drivers accounted for 16% of variance in CRP status, with obesity emerging as most dominant contributor. This pattern was most pronounced in females; in males it was more diffuse, with a more prominent role for smoking. Conclusions: We propose a decision tree framework where CRP can serve as a first-line screening marker for inflammation in SMI, with subsequent steps focusing on the main contributing factors to guide targeted interventions. Priority should be given to targeting obesity and metabolic dysregulation. Among females, hyperuricemia represents the next most appropriate target, whereas in males, smoking warrants greater attention. This stepwise approach provides a route from a nonspecific biomarker to targeted treatment strategies and should be validated in prospective studies.
Fichiers liés : 1-s2.0-S0889159126002126-main.pdf
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Differences in Use of Disease-Modifying Therapies Between Patients With Late-Onset and Adult-Onset Relapsing-Remitting Multiple Sclerosis
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Antoine GavoilleAnne KerbratGilles EdanEmmanuelle Le PageFabien RollotRomain CaseyGuillaume MatheyBruno StankoffJonathan CironJérôme de SèzeAurélie RuetPierre M. LabaugeArnaud KwiatkowskiHélène ZéphirCaroline PapeixGilles-Louis DeferChristine Lebrun-FrenayThibault MoreauEric BergerPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabThomas DavidLaurent MagyJean-Philippe CamdessanchéSolène MoulinInès DoghriMariana SarovAmélie dos SantosCorinne PottierÉric ManchonJennifer AboabMaya TchikviladzeCamille DahanPierre DurozardClarisse Scherer-GagouAlexandre LeclancherDavid-Axel LaplaudSandra VukusicLaure Michel
Differences in Use of Disease-Modifying Therapies Between Patients With Late-Onset and Adult-Onset Relapsing-Remitting Multiple Sclerosis
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Antoine GavoilleAnne KerbratGilles EdanEmmanuelle Le PageFabien RollotRomain CaseyGuillaume MatheyBruno StankoffJonathan CironJérôme de SèzeAurélie RuetPierre M. LabaugeArnaud KwiatkowskiHélène ZéphirCaroline PapeixGilles-Louis DeferChristine Lebrun-FrenayThibault MoreauEric BergerPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabThomas DavidLaurent MagyJean-Philippe CamdessanchéSolène MoulinInès DoghriMariana SarovAmélie dos SantosCorinne PottierÉric ManchonJennifer AboabMaya TchikviladzeCamille DahanPierre DurozardClarisse Scherer-GagouAlexandre LeclancherDavid-Axel LaplaudSandra VukusicLaure Michel
- Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique de Nancy Institut du Cerveau = Paris Brain Institute AP-HP - Hôpital de la Pitié Salpêtrière Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] CIC Strasbourg Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Hôpital Saint Vincent de Paul [Lille] Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Service de Neurologie [CHU Caen] Normandie Université UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Hôpital Pasteur [Nice] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Service de Neurologie [CHRU Besançon] Service Neurologie [CHU Clermont-Ferrand] Neuro-Dol Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre Hospitalier Intercommunal de Poissy/Saint-Germain-en-Laye Hôpital de la Timone [CHU - APHM] Aix Marseille Université Neurologie [CHU Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Psychiatrie et Neurologie personnalisées [CHU Henri-Mondor] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Service de Neurologie [CHU Limoges] Service de Neurologie [CHU de Saint-Étienne] Service de neurologie [Reims] Centre Hospitalier Régional Universitaire de Tours Service de neurologie [Le Kremlin Bicêtre] Service de neurologie [CHU de Poitiers] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre Hospitalier René Dubos [Pontoise] Centre Hospitalier de Gonesse Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts Hôpital Foch [Suresnes] Centre hospitalier de Pau Centre hospitalier d'Ajaccio Service de neurologie [Angers] Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CIC Plurithématique de Nantes Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Service de Neurologie [Rennes] = Neurology [Rennes] Centre d'Investigation Clinique [Rennes]
- Publié dans Neurology le 01/11/2020
Résumé : Background and objectives: The therapeutic strategy for late-onset multiple sclerosis (LOMS) with a relapsing-remitting onset remains unclear, potentially leading to underexposure to disease-modifying therapies (DMTs) compared with adult-onset multiple sclerosis (AOMS). We investigated the differences in DMT use between LOMS and AOMS within the French MS registry at comparable levels of disease severity. Methods: This retrospective cohort study used data extracted in December 2024 from the French MS registry on patients with relapsing-remitting onset MS between 1997 and 2023. The primary outcome was the annual probability of receiving a DMT according to age at MS onset, adjusted for disease severity. Secondary outcomes included the annual probability of receiving a highly effective DMT (HEDMT), each DMT separately, having ≥1 EDSS measurement, having ≥1 brain MRI, and DMT initiations and discontinuations. We used a longitudinal logistic model with generalized estimating equations and an inverse-probability-of-censoring weighting. Results: A total of 36,148 were included patients; 26,540 (73.4%) were female, mean age was 33.5 years (SD, 9.7), and 2,308 (6.4%) were aged ≥50 at disease onset. Median follow-up was 10.8 years (interquartile range, 5.6-17.0). Patients with LOMS had a lower annual probability of receiving a DMT compared with patients with AOMS (73.7% vs 83.1%; odds ratio [OR], 0.57 [95% CI 0.52-0.62]). The difference was greater for HEDMT (24.6% vs 44.4%; OR, 0.41 [95% CI 0.36-0.46]). Patients with LOMS were more likely to receive teriflunomide and less likely to receive fumarates, S1PR modulators, natalizumab, or anti-CD20. Clinical and radiologic follow-up did not differ significantly between patients with LOMS and AOMS. The rate of DMT initiation was lower in patients with LOMS (0.13 vs 0.17 initiation per patient-year). Although the proportions of DMT discontinuation were similar (59.7% vs 60.4%, excluding pregnancy-related discontinuations), these discontinuations were more often attributed to a complete discontinuation strategy (27.9% vs 22.3%) and less often to an escalation strategy (9.2% vs 13.8%) in patients with LOMS. Discussion: At comparable levels of disease severity, patients with LOMS were less likely to be treated with DMTs, particularly HEDMT, than patients with AOMS. This gap was driven both by fewer DMT initiations and more frequent complete discontinuations.
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Time to diagnosis and treatment of obstructive sleep apnoea using mandibular jaw movement monitoring versus polysomnography: an open-label, multicentre, randomised, controlled trial
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Jean-Louis PepinRenaud TamisierMarc ManceauKatleen DenoncinArnaud PrigentMaxime PatoutHervé PégliascoF. GagnadouxJean-Benoît MartinotMatthieu RoustitSarah AlexandreSébastien BaillieulLucie BarateauClara BianquisYvan BellangerHélène BenzaquenLaurent BoyerNicolas CarpentierElena CharbonnierAri ChaouatRita ClinJulien CoelhoAla CovaliYves DauvilliersClaire DenisMarie DestorsMarie Pia D’orthoAntoine DumazetJustine FrijaSacha GaillardThibaut GentinaMaëlle GuellerinKelly GuichardLaurence Hertert-GandolfoBenjamin HuretAntoine JaffiolFrançois JounieauxPhilippe LangClaire LaunoisDamien LégerSmaranda Leu-SemenescuRim LeymarieCécile LondnerQuentin LorberMarie-Noëlle Lothe-CartierRégis LuraineGuillaume MarchandNicole MeslierJean-Arthur Micoulaud-FranchiPierre-Jean MonteyrolPauline MuletteMarina OgierCécile OlivierCaroline PagniezAlbert PajonYasmina Pascaud-MansourLaure Peter-DerexPierre PhilipCarole PlanèsSandrine Pontier-MarchandiseVincent PuelNathalie RaymondBruno Ribeiro-BaptistaRodrigue RibereauFrançois RicordeauCécile RoparsMarc SapèneKamila SedkaouiEmeric StaufferJonathan TaiebMarion TaillandAnnie TangtakounPierre TankereWojciech TrzepizurCamille ValeryOlivier VarnetAnne Wittenberg
Time to diagnosis and treatment of obstructive sleep apnoea using mandibular jaw movement monitoring versus polysomnography: an open-label, multicentre, randomised, controlled trial
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Jean-Louis PepinRenaud TamisierMarc ManceauKatleen DenoncinArnaud PrigentMaxime PatoutHervé PégliascoF. GagnadouxJean-Benoît MartinotMatthieu RoustitSarah AlexandreSébastien BaillieulLucie BarateauClara BianquisYvan BellangerHélène BenzaquenLaurent BoyerNicolas CarpentierElena CharbonnierAri ChaouatRita ClinJulien CoelhoAla CovaliYves DauvilliersClaire DenisMarie DestorsMarie Pia D’orthoAntoine DumazetJustine FrijaSacha GaillardThibaut GentinaMaëlle GuellerinKelly GuichardLaurence Hertert-GandolfoBenjamin HuretAntoine JaffiolFrançois JounieauxPhilippe LangClaire LaunoisDamien LégerSmaranda Leu-SemenescuRim LeymarieCécile LondnerQuentin LorberMarie-Noëlle Lothe-CartierRégis LuraineGuillaume MarchandNicole MeslierJean-Arthur Micoulaud-FranchiPierre-Jean MonteyrolPauline MuletteMarina OgierCécile OlivierCaroline PagniezAlbert PajonYasmina Pascaud-MansourLaure Peter-DerexPierre PhilipCarole PlanèsSandrine Pontier-MarchandiseVincent PuelNathalie RaymondBruno Ribeiro-BaptistaRodrigue RibereauFrançois RicordeauCécile RoparsMarc SapèneKamila SedkaouiEmeric StaufferJonathan TaiebMarion TaillandAnnie TangtakounPierre TankereWojciech TrzepizurCamille ValeryOlivier VarnetAnne Wittenberg
- Organismes : Hypoxie et PhysioPathologie Université Grenoble Alpes - UFR Médecine Hypoxie et PhysioPathologie CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Hypoxie et PhysioPathologie Hypoxie : Physiopathologie Respiratoire et Cardiovasculaire Hypoxie et PhysioPathologie Hypoxie et PhysioPathologie Hypoxie et PhysioPathologie
- Publié dans The Lancet Regional Health - Europe le 21/04/2021
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Interictal epileptiform discharges are involved in momentary lapses of attention in children with epilepsy
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Marine ThieuxRomain BouetJulien JungPhilippe KahaneLaurent VercueilLucie MartinetMarcela Perrone-BertolottiJean-Philippe LachauxJulitta de BellescizeVania Herbillon
Interictal epileptiform discharges are involved in momentary lapses of attention in children with epilepsy
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Marine ThieuxRomain BouetJulien JungPhilippe KahaneLaurent VercueilLucie MartinetMarcela Perrone-BertolottiJean-Philippe LachauxJulitta de BellescizeVania Herbillon
- Organismes : Équipe Physiologie Intégrée du Système d'Éveil - Integrated Physiology of the Brain Arousal Systems Team Neurosciences de l’Expérience Subjective et Entraînement Mental - Experiential Neuroscience and Mental Training Neurosciences de l’Expérience Subjective et Entraînement Mental - Experiential Neuroscience and Mental Training Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Laboratoire de Psychologie et NeuroCognition Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Laboratoire de Psychologie et NeuroCognition Neurosciences de l’Expérience Subjective et Entraînement Mental - Experiential Neuroscience and Mental Training Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL] Équipe Physiologie Intégrée du Système d'Éveil - Integrated Physiology of the Brain Arousal Systems Team Service de neurologie fonctionnelle et d'épileptologie [Hôpital Pierre Wertheimer-HCL]
- Publié dans Epilepsia le 22/10/2020
Résumé : Objective Attention impairments are common in children with epilepsy and widely impact their quality of life. Interictal epileptiform discharges (IEDs) may induce subtle dysfunctions of various cognitive processes, but data regarding the impact of IEDs on sustained attention remain limited. The objective of the present study was to evaluate the impact of IEDs on continuous undivided attention in children with epilepsy, controlling for the number of treatments, type of epilepsy, frequency of seizures in the past year, age at onset, and comorbid attention disorder. Methods Using a computerized sustained attention test synchronized with the electroencephalogram in 61 children with diverse epilepsy syndromes, reaction time (RT), errors, attention stability over time, and the event‐related potential (ERP) in Pz (related to attentional engagement) were collected. The cumulative impact of IEDs was evaluated using multivariate models controlling for epilepsy‐related factors. The transient impact of IEDs was assessed by comparing responses in trials with and without IEDs. Results IEDs were associated with attention fluctuations independently from other epilepsy‐related factors. In terms of cumulative impact, a higher IED rate was associated with a poorer sustained attention performance over the entire task. In terms of transient impact, trials disrupted by IEDs were characterized by longer RT and a lower amplitude of the ERP extending over a long time window that included attentional processing (P300). Significance These results suggest that IEDs may negatively impact sustained attention, independently of other epilepsy‐related features. These findings support the hypothesis that IEDs could contribute to subtle attentional deficits and serve as potential biomarkers of abnormal brain function.
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Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Amrou SarrajGötz ThomallaShinichi YoshimuraXiaochuan HuoVincent CostalatOsama ZaidatCaroline ArquizanHannah JohnsVignan YogendrakumarLeonid ChurilovDeep PujaraClark SittonDavid LiebeskindManabu InoueCharles MajoieLudo BeenenMohammad Ammar AbdulrazzakAditya ChaturvediSarthak SinghMark ParsonsA. DenisNobuyuki SakaiThanh NguyenJean François AlbucherSami Al KasabAmeer HassanMichael AbrahamAnsar RaiHilde HenonDapeng SunHiroshi YamagamiFabien SubtilSusanne BonekampKazutaka UchidaGuangxiong YuanBenjamin GoryWade SmithSantiago Ortega-GutierrezSpiros BlackburnSunil ShethGaultier MarnatLiping LiuManabu ShirakawaJens FiehlerMärit JensenSeigo ShindoRaul NogueiraRamesh GrandhiPascal JabbourMuhammad Shazam HussainDiederik DippelYilong WangYukako YazawaClaus SimonsenYongjun WangMichael ChenMichael HillJames GrottaBertrand LapergueTudor JovinAlbert YooMartin BendszusBruce CampbellTakeshi MorimotoZhongrong MiaoShinichi YoshimuraNobuyuki SakaiHiroshi YamagamiTakeshi MorimotoKazunori ToyodaYuji MatsumaruYasushi MatsumotoKazumi KimuraNaoya KuwayamaKuniaki OgasawaraTeruyuki HiranoReiichi IshikuraManabu InoueFumihiro SakakibaraNorito KinjoTakuya SaitoKazutaka UchidaMikiya BeppuAkito UchioMasataka TakeuchiYasushi MatsumotoNaoto KimuraKeigo ShigetaSeigo ShindoHirotoshi ImamuraIchiro SuzukiYukiko EnomotoSo TokunagaKenichi MoritaKanta TanakaRyuzaburo KanazawaTakumi AsaiNorihito ShimamuraHideyuki IshiharaMasafumi MorimotoHiroyuki OhnishiYoshinori AkiyamaNobuhisa MatsushitaNobuaki YamamotoKoichi HaraguchiHayato ArakiAtsushi OgataHirotaka OkumuraTatsuya OginoYoshitaka YamadaTakahiro OtaYoshifumi TsuboiTakehiro YamadaManabu NagataKenichi TodoFuminori ShimizuYasushi UenoMasataka YoshimuraWataro TsurutaYoichi MorofujiNaoki TomaTomoya OmaeMakoto SakamotoToshihiro UedaShinya KoyamaYongjun WangYilong WangLiping LiuDavid LiebeskindZhongrong MiaoZeguang RenVitor Mendes PereiraXunming JiQiang DongAnding XuXinfeng LiuQingwu YangJing JingZhe ZhangYingkui ZhangWei WuJianmin LiuChen YaoKangning ChenKun FangBo SongYi DongXiaochuan HuoGaoting MaGuangxiong YuanHongxing HanWenhuo ChenMing WeiJiangang ZhangZhiming ZhouXiaoxi YaoGuoqing WangWeigen SongXueli CaiGuangxian NanDi LiYizhou WangWentong LingChuwei CaiChangming WenEn WangLiyong ZhangChangchun JiangYajie LiuGeng LiaoXiaohui ChenTianxiao LiShudong LiuJinglun LiYaxuan SunNa XuZong'En GaoDongsheng JuCunfeng SongJinggang XuanFeng ZhouQing ShiJun LuoYan LiuZaiyu GuoTong LiHongbo ZhengLinzhi DaiJunfeng ZhaoLiqiang GuiXiaokun GengYufeng TangCongguo YinHua YangYuesong PanAoming JinXianglong XiangMengxing WangHongyi YanYuanling HeChunyang LiAmrou SarrajSophia SundararajanYin HuCathy SilaAnthony FurlanAmanda OpaskarNicholas BambakidisAbhishek RayJeffrey SunshineSepideh Amin-HanjaniMichael DegeorgiaWei XiongRose DuncanAli FadhilAri BlitzJennifer SommerJohn HansenMohit PatelArunit ChughFaisal Al-ShaibiMajed AlomarSoheil El-AzzouniRami MoussaDasul JinKatrina NayakYiyi ZhangNikhil ModakMuruj JumahDeng-Yuan Dean LiouAbdullah AlamoudiAlex ChenSean Michael DukeYazid SaidiAbdalmalik Khalid Bin KhunayfirRami IbrahimAlexander LewisHemani TickuAnthony Peter ZampinoDeep PujaraSpiros BlackburnJames GrottaClark SittonMark DannenbaumRoy RiascosGary SpiegelAndrew BarretoFaris ShakerAnjail SharieffJoseph CochranArthur DayNicole GonzalesSujan ReddyLauren FournierErica JonesPamela ZeliniHaris KamalFelix Guerra CastanonNaveed AsimLaith MaaliKoji EbersoleJorge KawanoColleen LechtenbergSabreena SlavinLatih MaaliErnest MadarangAparna PendurthiAbid QureshiAlan ReevesLee RostermanYunxia WangTiffany Thu BarkleyHusitha VanguruJeremy PatersonCarissa WaltersPeyton AckermanRicardo HanelAmin AghaebrahimEric SauvageauGina MundenM. 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Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Amrou SarrajGötz ThomallaShinichi YoshimuraXiaochuan HuoVincent CostalatOsama ZaidatCaroline ArquizanHannah JohnsVignan YogendrakumarLeonid ChurilovDeep PujaraClark SittonDavid LiebeskindManabu InoueCharles MajoieLudo BeenenMohammad Ammar AbdulrazzakAditya ChaturvediSarthak SinghMark ParsonsA. DenisNobuyuki SakaiThanh NguyenJean François AlbucherSami Al KasabAmeer HassanMichael AbrahamAnsar RaiHilde HenonDapeng SunHiroshi YamagamiFabien SubtilSusanne BonekampKazutaka UchidaGuangxiong YuanBenjamin GoryWade SmithSantiago Ortega-GutierrezSpiros BlackburnSunil ShethGaultier MarnatLiping LiuManabu ShirakawaJens FiehlerMärit JensenSeigo ShindoRaul NogueiraRamesh GrandhiPascal JabbourMuhammad Shazam HussainDiederik DippelYilong WangYukako YazawaClaus SimonsenYongjun WangMichael ChenMichael HillJames GrottaBertrand LapergueTudor JovinAlbert YooMartin BendszusBruce CampbellTakeshi MorimotoZhongrong MiaoShinichi YoshimuraNobuyuki SakaiHiroshi YamagamiTakeshi MorimotoKazunori ToyodaYuji MatsumaruYasushi MatsumotoKazumi KimuraNaoya KuwayamaKuniaki OgasawaraTeruyuki HiranoReiichi IshikuraManabu InoueFumihiro SakakibaraNorito KinjoTakuya SaitoKazutaka UchidaMikiya BeppuAkito UchioMasataka TakeuchiYasushi MatsumotoNaoto KimuraKeigo ShigetaSeigo ShindoHirotoshi ImamuraIchiro SuzukiYukiko EnomotoSo TokunagaKenichi MoritaKanta TanakaRyuzaburo KanazawaTakumi AsaiNorihito ShimamuraHideyuki IshiharaMasafumi MorimotoHiroyuki OhnishiYoshinori AkiyamaNobuhisa MatsushitaNobuaki YamamotoKoichi HaraguchiHayato ArakiAtsushi OgataHirotaka OkumuraTatsuya OginoYoshitaka YamadaTakahiro OtaYoshifumi TsuboiTakehiro YamadaManabu NagataKenichi TodoFuminori ShimizuYasushi UenoMasataka YoshimuraWataro TsurutaYoichi MorofujiNaoki TomaTomoya OmaeMakoto SakamotoToshihiro UedaShinya KoyamaYongjun WangYilong WangLiping LiuDavid LiebeskindZhongrong MiaoZeguang RenVitor Mendes PereiraXunming JiQiang DongAnding XuXinfeng LiuQingwu YangJing JingZhe ZhangYingkui ZhangWei WuJianmin LiuChen YaoKangning ChenKun FangBo SongYi DongXiaochuan HuoGaoting MaGuangxiong YuanHongxing HanWenhuo ChenMing WeiJiangang ZhangZhiming ZhouXiaoxi YaoGuoqing WangWeigen SongXueli CaiGuangxian NanDi LiYizhou WangWentong LingChuwei CaiChangming WenEn WangLiyong ZhangChangchun JiangYajie LiuGeng LiaoXiaohui ChenTianxiao LiShudong LiuJinglun LiYaxuan SunNa XuZong'En GaoDongsheng JuCunfeng SongJinggang XuanFeng ZhouQing ShiJun LuoYan LiuZaiyu GuoTong LiHongbo ZhengLinzhi DaiJunfeng ZhaoLiqiang GuiXiaokun GengYufeng TangCongguo YinHua YangYuesong PanAoming JinXianglong XiangMengxing WangHongyi YanYuanling HeChunyang LiAmrou SarrajSophia SundararajanYin HuCathy SilaAnthony FurlanAmanda OpaskarNicholas BambakidisAbhishek RayJeffrey SunshineSepideh Amin-HanjaniMichael DegeorgiaWei XiongRose DuncanAli FadhilAri BlitzJennifer SommerJohn HansenMohit PatelArunit ChughFaisal Al-ShaibiMajed AlomarSoheil El-AzzouniRami MoussaDasul JinKatrina NayakYiyi ZhangNikhil ModakMuruj JumahDeng-Yuan Dean LiouAbdullah AlamoudiAlex ChenSean Michael DukeYazid SaidiAbdalmalik Khalid Bin KhunayfirRami IbrahimAlexander LewisHemani TickuAnthony Peter ZampinoDeep PujaraSpiros BlackburnJames GrottaClark SittonMark DannenbaumRoy RiascosGary SpiegelAndrew BarretoFaris ShakerAnjail SharieffJoseph CochranArthur DayNicole GonzalesSujan ReddyLauren FournierErica JonesPamela ZeliniHaris KamalFelix Guerra CastanonNaveed AsimLaith MaaliKoji EbersoleJorge KawanoColleen LechtenbergSabreena SlavinLatih MaaliErnest MadarangAparna PendurthiAbid QureshiAlan ReevesLee RostermanYunxia WangTiffany Thu BarkleyHusitha VanguruJeremy PatersonCarissa WaltersPeyton AckermanRicardo HanelAmin AghaebrahimEric SauvageauGina MundenM. 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- Organismes : The University of Texas Health Science Center at Houston Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg] University of Hyogo Beijing Normal University Neuroradiologie [Hôpital Gui de Chauliac] Medical College of Wisconsin Département de Neurologie [Hôpital Gui de Chauliac - CHU Montpellier] Ottawa Hospital Research Institute [Ottawa] University of California [Los Angeles] National Cerebral and Cardiovascular Center [Osaka, Japon] Amsterdam University Medical Centers Academic Medical Center - Academisch Medisch Centrum [Amsterdam] Indian Institute of Technology [Dhanbad] University of New South Wales [Sydney] Ingham Institute for Applied Medical Research [Liverpool, NSW, Australia] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Département biostatistiques et modélisation pour la santé et l'environnement [LBBE] Biostatistiques santé [LBBE] Pharmacologie et Pathologies Fragilisantes
- Publié dans The Lancet le 02/11/2020
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Cemiplimab versus historical systemic treatments for locally advanced or metastatic cutaneous squamous cell carcinomas: Results from the French study TOSCA
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Caroline RobertEmilie GérardEmilie LanoyGaelle QuéreuxPhilippe BernardManuelle ViguierFlorent GrangeNicolas MeyerMonica DinulescuDelphine LegoupilEve Marie NeidhardtPhilippe SaiagSabiha TrabelsiPhilippe CélérierCharlee NardinEve MaubecAnne-Benedicte Duval- ModesteEwa HainautSophie DarrasHerve MaillardSarah GueganJean Philippe ArnaultPierre-Emmanuel StoebnerYannick Le CorreLucie PeuvrelBertille BonniaudHugo HerrscherFlorence Granel-BrocardAnne-Lise VataireAurore TabellionCéleste LebbéLaurent Mortier
Cemiplimab versus historical systemic treatments for locally advanced or metastatic cutaneous squamous cell carcinomas: Results from the French study TOSCA
- Type de publi. : Article dans une revue
- Date de publi. : 01/05/2026
- Auteurs : Caroline RobertEmilie GérardEmilie LanoyGaelle QuéreuxPhilippe BernardManuelle ViguierFlorent GrangeNicolas MeyerMonica DinulescuDelphine LegoupilEve Marie NeidhardtPhilippe SaiagSabiha TrabelsiPhilippe CélérierCharlee NardinEve MaubecAnne-Benedicte Duval- ModesteEwa HainautSophie DarrasHerve MaillardSarah GueganJean Philippe ArnaultPierre-Emmanuel StoebnerYannick Le CorreLucie PeuvrelBertille BonniaudHugo HerrscherFlorence Granel-BrocardAnne-Lise VataireAurore TabellionCéleste LebbéLaurent Mortier
- Organismes : Université Paris-Saclay Département de médecine oncologique [Gustave Roussy] Hôpital Saint-André CIC - HEGP Immunology and New Concepts in ImmunoTherapy Centre Hospitalier Universitaire Dupuytren 1 et 2 Hôpital universitaire Robert Debré [Reims] Centre hospitalier de Valence Clinique Médipôle Garonne CRLCC Eugène Marquis Hôpital Morvan [Brest] Centre Léon Bérard [Lyon] AP-HP - Hôpital Ambroise Paré CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier de la Rochelle - Ré Aunis- Hôpital Saint Louis Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) AP-HP - Hôpital Avicenne CHU Rouen Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Centre Hospitalier Boulogne-sur-mer Centre Hospitalier Le Mans (CH Le Mans) Paris Santé Cochin Centre Hospitalier Universitaire d'Amiens-Picardie Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Universitaire d'Angers Institut de Cancérologie de l'Ouest [Angers/Nantes] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Groupe Hospitalier Saint-Vincent Centre Hospitalier Régional Universitaire de Nancy Sanofi Winthrop Industry [Paris] Sanofi Winthrop Industry [Paris] Immunologie humaine, physiopathologie & immunothérapie Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189
- Publié dans European Journal of Cancer le 22/10/2020
Résumé : Background: Cemiplimab an anti-programmed cell death receptor-1 antibody, was approved by the FDA and EMA for patients with locally advanced cutaneous squamous cell carcinoma (laCSCC) ineligible for curative surgery/radiotherapy or with metastatic (m) CSCC. TOSCA study evaluated the real-world effectiveness and safety of cemiplimab compared to historical systemic therapies (HSTs). Methods: TOSCA (NCT05302297) was a large French retrospective, multicenter study comparing patient with la/mCSCC treated with cemiplimab via the early access program (EAP, 2018-2019) or HST (2013-2018). The primary endpoint was overall survival (OS); secondary endpoints were progression-free survival (PFS), duration of response (DoR), overall response rate (ORR), and safety. Effectiveness analysis using inverse probability weighting included a trial-like cohort of only immunocompetent patients meeting the EAP criteria to emulate a randomized clinical trial; safety analysis included all real-life patients. Findings: The study included 280 real-life patients (cemiplimab: n = 147; HST: n = 133). The primary effectiveness analysis included a trial-like cohort (cemiplimab: n = 129; HST: n = 70; median age: 81 and 78 years, respectively). Median follow-up was 20 and 10 months in the cemiplimab and HST arms, respectively; median OS was 21.2 and 9.8 months, respectively (HR 95% CI: 0.57 [0.45-0.73]; P < 0.0001); median PFS was 13.7 and 5.3 months, respectively (HR [95% CI]: 0.57 [0.43-0.76]; P = 0.0001). Adverse drug reactions occurred in 27% of cemiplimab patients and 33% of HST patients. Interpretation: TOSCA demonstrated better survival and response outcomes for cemiplimab versus HST in la/mCSCC; emphasizing, the importance of this retrospective studie in the absence of standard comparative trials.
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Directeur de l’Ecole Doctorale Sciences Humaines et Sociales