Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 26/06/2023
• Auteurs : Jean-Philippe AnkerPierre GermainTristan Léger
• Organismes : Institut Denis Poisson Department of Mathematics [Imperial College London] Department of Mathematics - Princeton University

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Résumé : In this paper, we prove L2 → Lp estimates, where p>2, for spectral projectors on a wide class of hyperbolic surfaces. More precisely, we consider projections in small spectral windows [λ−η, λ+η] on geometrically finite hyperbolic surfaces of infinite volume. In the convex cocompact case, we obtain optimal bounds with respect to λ and η, up to subpolynomial losses. The proof combines the resolvent bound of Bourgain-Dyatlov and improved estimates for the Schrödinger group (Strichartz and smoothing estimates) on hyperbolic surfaces.

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Fichiers liés : spectral-proj-quo-finalv2.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/06/2023
• Auteurs : Antoine RollandBaptiste LabeyrieBertrand GauffreBlandine RosiesClaire LavigneChristophe MouirenClémence MonotDaniele BevacquaDaniel PlénetFrançoise LescourretFrédéric NormandGilles VercambreHélène GautierIsabelle GrechiJean-Noël AubertotJulie BorgJulien RueschLaurent GomezMarie-Hélène RobinMichel GénardMohamed-Mahmoud MemahNatacha SautereauOctave LacroixPascal BorioliPhilippe BlancPierre FranckPierre ValsesiaStéphanie DruschValérie GalliaVincent Mercier
• Organismes : Université Lumière - Lyon 2 Centre technique interprofessionnel des fruits et légumes Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut Technique de l'Agriculture Biologique Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement GRCETA de Basse Durance Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Fonctionnement agroécologique et performances des systèmes de cultures horticoles Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Fonctionnement agroécologique et performances des systèmes de cultures horticoles Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Centre technique interprofessionnel des fruits et légumes Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut Technique de l'Agriculture Biologique Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement GRCETA de Basse Durance CETA du Vidourle Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement SudExpé Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement

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Résumé : We propose to share with the community the progress of our ongoing project named ODACE (2021-2024). ODACE aims to develop a tool to help stakeholders in reducing the use of phytosanitary products in orchards. We are developing a modeling approach that allows a better understanding of the interactions between plants and pests and their management by practices and planned biodiversity, including service plants that are still underused. The tool, using fruit crop models QauliTree and Vmango and inspired by the formalism of the IPSIM damage model, aims to explicitly take into account the effects of several alternative levers to pesticides on multiple pest damage, and the impacts of this damage on fruit production. These alternatives are evaluated on several criteria : ecosystem services, environmental impact indicators, socio-economic performance, and health risks. We are considering several stakeholder's profiles with contrasting preferences and using simualtion to identify and archive a large number of solutions suitable for each stakeholder profile. Multi-criteria decision support and preference elicitation methods are implemented to learn the stakeholders reasoning. At the end, the tool will allow to test in silico most suitable scenarios for users (organic, zero pesticides, integrated) and to evaluate their social acceptability. To test the generality of the approach, the tool will be developed for apple and peach and initiated on mango.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 26/06/2023
• Auteurs : Sandrine CosteAbdelali ZakiKillian MacheF. FégerAntoine PautonnierJiacheng YuMathilde RieuMaxime MinotMaud BarréJean-Paul ViricellePhilippe LacorreP.-E. Janolin
• Organismes : Institut des Molécules et Matériaux du Mans Laboratoire Structures, Propriétés et Modélisation des solides SPMS-Pytheas Technology SPyMS LabCom Institut des Molécules et Matériaux du Mans Institut des Molécules et Matériaux du Mans Laboratoire Structures, Propriétés et Modélisation des solides SPMS-Pytheas Technology SPyMS LabCom Centre Sciences des Processus Industriels et Naturels Laboratoire Georges Friedel Centre Sciences des Processus Industriels et Naturels Laboratoire Georges Friedel Institut des Molécules et Matériaux du Mans Centre Sciences des Processus Industriels et Naturels Laboratoire Georges Friedel Institut des Molécules et Matériaux du Mans Laboratoire Structures, Propriétés et Modélisation des solides

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• Type de publi. : Article dans une revue
• Date de publi. : 24/06/2023
• Auteurs : M SébillotteDavid BoutoilleCharles DeclerckJean-Philippe TalarminAdrien LemaignenCaroline PiauMatthieu RevestPierre TattevinMarie Gousseff
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d’Investigation Clinique de Nantes Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN régulateurs bactériens et médecine Centre hospitalier Bretagne Atlantique (Morbihan)
• Publié dans Infectious diseases (London, England) le 01/11/2020

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Résumé : BACKGROUND: Infective endocarditis (IE) caused by non-HACEK gram-negative bacilli (GNB) is poorly characterised and may be emerging as a consequence of medical progress. METHODS: We performed an observational retrospective case-control study. Cases were non-HACEK GNB IE, definite or possible (modified Duke criteria), diagnosed in adults between 2007 and 2020 in six French referral hospitals. Two controls were included for each case (IE due to other bacteria, matched by sites and diagnosis date). RESULTS: Non-HACEK GNB were identified in 2.4% (77/3230) of all IE during the study period, with a mean age of 69.2 ± 14.6 years, and a large male predominance (53/77, 69%). Primary pathogens were Escherichia coli (n = 33), Klebsiella sp. (n = 12) and Serratia marcescens (n = 9), including eight (10%) multidrug-resistant GNB. Compared to controls (n = 154: 43% Streptococcus sp., 41% Staphylococcus sp. and 12% Enterococcus sp.), non-HACEK GNB IE were independently associated with intravenous drug use (IVDU, 8% vs. 2%, p = .003), active neoplasia (15% vs. 6%, p = .009), haemodialysis (9% vs. 3%, p = .007) and healthcare-associated IE (36% vs. 18%, p = .002). Urinary tract was the main source of infection (n = 25, 33%) and recent invasive procedures were reported in 29% of cases. Non-HACEK GNB IE were at lower risk of embolism (31% vs. 47%, p = .002). One-year mortality was high (n = 28, 36%). Comorbidities, particularly malignant hemopathy and cirrhosis, were associated with increased risk of death. CONCLUSIONS: Non-HACEK GNB are rarely responsible for IE, mostly as healthcare-associated IE in patients with complex comorbidities (end-stage renal disease, neoplasia), or in IVDUs.

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Fichiers liés : Sebillotte et al-2023-Non-HACEK gram-negative bacilli endocarditis A multicentre retrospective case-control study.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 21/06/2023
• Auteurs : Daniela-Elena Oprea-LagerEric GontierLina García-CañamaqueMathieu GauthéPierre OlivierMercedes MitjavilaPilar TamayoPhilippe RobinAna Maria García VicenteAnne-Charlotte BouyeureAlban BailliezAntonio Rodríguez-FernándezSinan Ben MahmoudJuan Antonio Vallejo-CasasPhilippe MaksudCharles MerlinPaul Blanc-DurandClément DrouetHubert TissotIrina VierasuThierry Vander BorghtEvelyne BoosFlorence ChossatMarina HodolicCaroline Rousseau
• Organismes : Amsterdam University Medical Centers Centre Jean Bernard [Institut Inter-régional de Cancérologie - Le Mans] Universidad San Pablo CEU CHU Tenon [AP-HP] Centre Hospitalier Régional Universitaire de Nancy Hospital Universitario Puerta de Hierro-Majadahonda [Madrid, Spain] Hospital General Universitario de Ciudad Real [Ciudad Real, Spain] Centre Hospitalier Régional Universitaire de Brest Hospital General Universitario de Ciudad Real [Ciudad Real, Spain] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Hôpital Saint Philibert [Lomme] Hôpital Privé Le Bois Ramsay Santé [Lille] Hospital Universitario Virgen de las Nieves [Granada, Spain] Escuela Andaluza de Salud Publica Centre hospitalier régional de Metz-Thionville Instituto Maimonides de Investigación Biomédica de Cordoba CHU Pitié-Salpêtrière [AP-HP] Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Université Paris-Est Créteil Val-de-Marne - Paris 12 Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] Institut Curie [Paris] Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis CHU UCL Namur Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers Institut de Cancérologie de l'Ouest [Angers/Nantes]
• Publié dans European Journal of Nuclear Medicine and Molecular Imaging le 30/10/2020

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Résumé : Purpose: Primary objective was to compare the per-patient detection rates (DR) of [18F]DCFPyL versus [18F]fluoromethylcholine positron emission tomography/computed tomography (PET/CT), in patients with first prostate cancer (PCa) biochemical recurrence (BCR). Secondary endpoints included safety and impact on patient management (PM). Methods: This was a prospective, open label, cross-over, comparative study with randomized treatment administration of [18F]DCFPyL (investigational medicinal product) or [18F]fluoromethylcholine (comparator). Men with rising prostate-specific antigen (PSA) after initial curative therapy were enrolled. [18F]DCFPyL and [18F]fluoromethylcholine PET/CTs were performed within a maximum time interval of 12 days. DR was defined as the percentage of positive PET/CT scans identified by 3 central imaging readers. PM was assessed by comparing the proposed pre-PET/CT treatment with the local treatment", defined after considering both PET/CTs. Results: A total of 205 patients with first BCR after radical prostatectomy (73%; median PSA = 0.46 ng/ml [CI 0.16;27.0]) or radiation therapy (27%; median PSA = 4.23 ng/ml [CI 1.4;98.6]) underwent [18F]DCFPyL- and/or [18F]fluoromethylcholine -PET/CTs, between July and December 2020, at 22 European sites. 201 patients completed the study. The per-patient DR was significantly higher for [18F]DCFPyL- compared to [18F]fluoromethylcholine -PET/CTs (58% (117/201 patients) vs. 40% (81/201 patients), p < 0.0001). DR increased with higher PSA values for both tracers (PSA ≤ 0.5 ng/ml: 26/74 (35%) vs. 22/74 (30%); PSA 0.5 to ≤ 1.0 ng/ml: 17/31 (55%) vs. 10/31 (32%); PSA 1.01 to < 2.0 ng/ml: 13/19 (68%) vs. 6/19 (32%);PSA > 2.0: 50/57 (88%) vs. 39/57 (68%) for [18F]DCFPyL- and [18F]fluoromethylcholine -PET/CT, respectively). [18F]DCFPyL PET/CT had an impact on PM in 44% (90/204) of patients versus 29% (58/202) for [18F]fluoromethylcholine. Overall, no drug-related nor serious adverse events were observed. Conclusions: The primary endpoint of this study was achieved, confirming a significantly higher detection rate for [18F]DCFPyL compared to [18F]fluoromethylcholine, in men with first BCR of PCa, across a wide PSA range. [18F]DCFPyL was safe and well tolerated.

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Fichiers liés : 259_2023_Article_6301.pdf

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• Type de publi. : Autre publication
• Date de publi. : 21/06/2023
• Auteurs : Gustavo BanegasKevin CarrierAndré ChaillouxAlain CouvreurThomas Debris-AlazardPhilippe GaboritPierre KarpmanJohanna LoyerRuben NiederhagenNicolas SendrierBenjamin SmithJean-Pierre Tillich
• Organismes : Qualcomm France RFFE SARL CY Cergy Paris Université Cryptologie symétrique, cryptologie fondée sur les codes et information quantique Geometry, arithmetic, algorithms, codes and encryption Geometry, arithmetic, algorithms, codes and encryption XLIM Calcul Algébrique et Symbolique, Sécurité, Systèmes Complexes, Codes et Cryptologie Cryptologie symétrique, cryptologie fondée sur les codes et information quantique Academia Sinica University of Southern Denmark Cryptologie symétrique, cryptologie fondée sur les codes et information quantique Geometry, arithmetic, algorithms, codes and encryption Cryptologie symétrique, cryptologie fondée sur les codes et information quantique

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Fichiers liés : main.pdf

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• Type de publi. : Autre publication
• Date de publi. : 21/06/2023
• Auteurs : Nicolas AragonMagali BardetLoïc BidouxJesús-Javier Chi-DomínguezVictor DyserynThibauld FeneuilPhilippe GaboritAntoine JouxMatthieu RivainJean-Pierre TillichAdrien Vinçotte
• Organismes : Naquidis Center Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes Cryptologie symétrique, cryptologie fondée sur les codes et information quantique Equipe Combinatoire et algorithmes Technology Innovation Institute [Abu Dhabi] Technology Innovation Institute [Abu Dhabi] Université de Limoges CryptoExperts Institut de Mathématiques de Jussieu - Paris Rive Gauche Université de Limoges Helmholtz Center for Information Security [Saarbrücken] CryptoExperts Cryptologie symétrique, cryptologie fondée sur les codes et information quantique Université de Limoges

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Fichiers liés : ryde-spec-web.pdf

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• Type de publi. : Autre publication
• Date de publi. : 21/06/2023
• Auteurs : Nicolas AragonMagali BardetLoïc BidouxJesús-Javier Chi-DomínguezVictor DyserynThibauld FeneuilPhilippe GaboritRomaric NeveuMatthieu RivainJean-Pierre Tillich
• Organismes : Naquidis Center Laboratoire d'Informatique, du Traitement de l'Information et des Systèmes Cryptologie symétrique, cryptologie fondée sur les codes et information quantique Equipe Combinatoire et algorithmes Technology Innovation Institute [Abu Dhabi] Technology Innovation Institute [Abu Dhabi] Université de Limoges CryptoExperts Institut de Mathématiques de Jussieu - Paris Rive Gauche Université de Limoges Université de Limoges CryptoExperts Cryptologie symétrique, cryptologie fondée sur les codes et information quantique

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Fichiers liés : MIRA-spec-web.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 20/06/2023
• Auteurs : Pierre JalinotLéa ProchassonMakram Mghezzi-HabellahJean-Philippe RobinArmelle RoisinVincent Mocquet
• Organismes : Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule

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• Type de publi. : Article dans une revue
• Date de publi. : 19/06/2023
• Auteurs : Luce Barbat Du CloselNathalie Bonello‐palotYann PéréonAndoni Echaniz-LagunaJean-Philippe CamdessanchéAleksandra Nadaj-PaklezaJean-Baptiste ChansonSimon FrachetLaurent MagyJulien CassereauPascal CintasAriane ChoumertPerrine DevicSarah Leonard LouisRobinson Gravier DumonceauEmilien DelmontEmmanuelle Campana-SalortFrançoise BouhourPhilippe LatourTanya StojkovicShahram AttarianLuce Barbat Du CloselJean‐baptiste ChansonSarah Leonard-LouisRobinson Gravier Dumonceau
• Organismes : Hôpital de la Timone [CHU - APHM] Marseille medical genetics - Centre de génétique médicale de Marseille Hôpital de la Timone [CHU - APHM] Hôtel-Dieu de Nantes Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Petites Molécules de neuroprotection, neurorégénération et remyélinisation Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre Hospitalier Universitaire d'Angers Hôpitaux Universitaires de Strasbourg Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques Neuroépidémiologie Tropicale Service de Neurologie [CHU Limoges] Centre de référence national neuropathies périphériques rares [CHU Limoges] Université d'Angers Département Neurologie [CHU Toulouse] CHU Sud Saint Pierre [Ile de la Réunion] Centre Hospitalier Lyon Sud [CHU - HCL] CHU Pitié-Salpêtrière [AP-HP] Biostatistique et technologies de l'information et de la communication (BioSTIC) - [Hôpital de la Timone - APHM] Hôpital de la Timone [CHU - APHM] Assistance Publique - Hôpitaux de Marseille Aix Marseille Université Hospices Civils de Lyon Groupement Hospitalier Lyon-Est CHU Pitié-Salpêtrière [AP-HP] Centre de recherche en Myologie – U974 SU-INSERM Hôpital de la Timone [CHU - APHM] Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques
• Publié dans European Journal of Neurology le 22/10/2020

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Résumé : Background X-Linked Charcot–Marie–Tooth disease type 1 (CMTX1) is characterized by gender differences in clinical severity. Women are usually clinically affected later and less severely than men. However, their clinical presentation appears to be heterogenous. Our aim was to extend the phenotypic description in a large series of women with CMTX1. Methods We retrospectively evaluated 263 patients with CMTX1 from 11 French reference centers. Demographic, clinical, and nerve conduction data were collected. The severity was assessed by CMT Examination Score (CMTES) and Overall Neuropathy Limitations Scale (ONLS) scores. We looked for asymmetrical strength, heterogeneous motor nerve conduction velocity (MNCV), and motor conduction blocks (CB). Results The study included 137 women and 126 men from 151 families. Women had significantly more asymmetric motor deficits and MNCV than men. Women with an age of onset after 19 years were milder. Two groups of women were identified after 48 years of age. The first group represented 55%, with women progressing as severely as men, however, with a later onset age. The second group had mild or no symptoms. Some 39% of women had motor CB. Four women received intravenous immunoglobulin before being diagnosed with CMTX1. Conclusions We identified two subgroups of women with CMTX1 who were over 48 years of age. Additionally, we have demonstrated that women with CMTX can exhibit an atypical clinical presentation, which may result in misdiagnosis. Therefore, in women presenting with chronic neuropathy, the presence of clinical asymmetry, heterogeneous MNCV, and/or motor CB should raise suspicion for X-linked CMT, particularly CMTX1, and be included in the differential diagnosis.

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Fichiers liés : Euro J of Neurology - 2023 - Barbat du Closel - Clinical and electrophysiological characteristics of women with X‐linked mmg.pdf

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