Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 19/12/2023
• Auteurs : Camille de CevinsLaure DelageMaxime BatignesQuentin RillerMarine LukaAnne RemauryBoris SorinTinhinane FaliCécile MassonBénédicte HoareauCatherine MeunierMélanie ParisotMohammed ZarhrateBrieuc P PérotVíctor García-ParedesFrancesco CarboneLou GalliotBéatrice NalPhilippe PierreLuc CanardCharlotte BoussardÉtienne CrickxJean-Claude GuillemotBrigitte Bader-MeunierAlexandre BelotPierre QuartierMarie-Louise FrémondBénédicte NevenGalina BoldinaFranck AugéAlain FischerMichel DidierFrédéric Rieux-LaucatMickaël Ménager
• Organismes : Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Sanofi Aventis R&D [Chilly-Mazarin] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Cytométrie Pitié-Salpêtrière Cytométrie Pitié-Salpêtrière Structure Fédérative de Recherche Necker Structure Fédérative de Recherche Necker Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Centre d'Immunologie de Marseille - Luminy Sanofi Aventis R&D [Chilly-Mazarin] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Sanofi Aventis R&D [Chilly-Mazarin] Hôpital Necker - Enfants Malades [AP-HP] Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling [CIRI] Hôpital Necker - Enfants Malades [AP-HP] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] Sanofi R&D Data and Data Science, Artificial Intelligence & Deep Analytics, Omics Data Science Sanofi R&D Data and Data Science, Artificial Intelligence & Deep Analytics, Omics Data Science Imagine - Institut des maladies génétiques (IHU) Sanofi Aventis R&D [Chilly-Mazarin] Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU)
• Publié dans Cell Reports Medicine le 01/11/2020

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Résumé : Gain-of-function mutations in stimulator of interferon gene 1 (STING1) result in STING-associated vasculopathy with onset in infancy (SAVI), a severe autoinflammatory disease. Although elevated type I interferon (IFN) production is thought to be the leading cause of the symptoms observed in patients, STING can induce a set of pathways, which have roles in the onset and severity of SAVI and remain to be elucidated. To this end, we performed a multi-omics comparative analysis of peripheral blood mononuclear cells (PBMCs) and plasma from SAVI patients and healthy controls, combined with a dataset of healthy PBMCs treated with IFN-β. Our data reveal a subset of disease-associated monocyte, expressing elevated CCL3, CCL4, and IL-6, as well as a strong integrated stress response, which we suggest is the result of direct PERK activation by STING. Cell-to-cell communication inference indicates that these monocytes lead to T cell early activation, resulting in their senescence and apoptosis. Last, we propose a transcriptomic signature of STING activation, independent of type I IFN response.

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 19/12/2023
• Auteurs : Arnaud DieudonnéClément BaillyFlorent CachinAgathe Edet-SansonFrançoise Kraeber-BodéréSébastien HapdeyCharles MerlinPhilippe RobinPierre-Yves SalaunPaul SchwartzDavid TonneletPierre VeraFrédéric CourbonThomas Carlier
• Organismes : Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Equipe Quantification en Imagerie Fonctionnelle Service de Médecine Nucléaire [Nantes] Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Equipe Quantification en Imagerie Fonctionnelle Service de Médecine Nucléaire [Nantes] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Equipe Quantification en Imagerie Fonctionnelle Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand] Service de médecine nucléaire [Brest] Service de médecine nucléaire [Brest] Service de médecine nucléaire [Bordeaux] Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen Equipe Quantification en Imagerie Fonctionnelle Institut Universitaire du Cancer de Toulouse - Oncopole Pôle imagerie médicale [CHU Toulouse] Service de Médecine Nucléaire [Nantes]
• Publié dans European Journal of Nuclear Medicine and Molecular Imaging le 30/10/2020

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Fichiers liés : Dieudonné_2024.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/12/2023
• Auteurs : Florian ReizineNicolas MassartVincent JoussellinAnaïs MachutCharles-Hervé VacheronAnne SaveyArnaud FriggeriAlain LepapeSerge AlfandariAlexandra AllaireAntonio AlvarezAmmenouche NacimLaurent ArgausGérard AudibertCaroline AurelOdile BajoletFrédéric BarbutGenevieve BarjonPatricia BauneSébastien BeagueBassam BeilounyNicolas BeleNicolas BelinCécile BernerdYasmina BerrouaneAziz BerroubaJulie BertrandClaire BianchiSandrine BiangomaFabienne Birot JaulinSeverine BonjeanStéphanie Bordes-CouecouAbdenour BouharaPhilippe BouillardCéline BourigaultSylvie BourzeixSébastien BoutreuxHanene BouzidiJulie BrochartStéphanie BulyezMarie CallanquinNathalie CanuMatthieu CapronDaniel CarbognaniVincent CastelainVincent CataneseIsabelle CattaneoVanessa ChartierGuillaume ChassaingRobert ChaussetMélanie ChauvetFabrice ChopinCatherine ChubilleauCéline ClayerAgnès CohenSylvie ComparotPhilippe CorneMarie-Elisabeth CornesseGaelle CornoEsther CortesPatricia CouroubleChristian CrombeVéronique CurnierMonzer DabbachiCédric DananchéAbla DaroukhDamien DassantMartine DaumasAurélien DauratDominique DeffargesFanny DelangheOlivier DelastreJoel DelhommeJean Paul DéliasMartine DelormeFabienne DerramondFrédérique DiawIsabelle DijolsKamel DjedainiLoic DopeuxSophie DuhooThierry DulacClarisse DupinLaurène DupontMichel DurandIsabelle Durand JolyJean-Yves DusseauPierre Yves EgreteauCarole EldinFlorence EspinasseEric FarfourAbdelhamid FatahYannick FedunLuis FerreiraPierre FillatreToufic FingeVéronique FleurialArnaud FlorentinAgnès FribourgSeverine Gallais-HoffClaude GallandRichard GalliotSylvain GarnierGaelle GasanJulien Gaubert-DuclosValérie GauzereThomas GeffriaudIsabelle GeneauHughes GeorgesSolweig Gerbier ColombanChristophe GiacardiSebastien GibotAudrey GlanardMarion GleizeMarieline GoretMichele GourguesDelphine GrauBéatrice GrisiClotilde GroleauLiliane Grolier-BoisCatherine GuignabertFethi Hadj-SlimaneEmmanuelle HammadCatherine HaondMarie Hélène HausermannFrancoise HayoChristophe HenryAlexandre HerblandJulien HuntzingerHervé HyvernatAlexandre JeanBoris JoliboisSylvie JoronGauthier JulienJean KempfLyes KnaniBéatrice La CombeMarie LabruyereSandrine LacroixBruno LafonKatia LamantPeggy LarroudéAnne LaunoyBernadette LaurentThierry LavigneChristine LawrenceQuoc Vien LeMuriel Le CoqAnne-Sophie Le FlochFanny Le FallBrigitte Le TallecLucie LecoutreStanislas LedochowskiRusel LeonClaire LepouseThomas LescotMélanie LevrardMarie Laure LierAnne LignereuxBenjamin LouartClaire MaheuAurélie MaindronFrancois MallardMarie Reine MallaretBernard MankikianChristiane ManzonPhilippe MardrusJacques MariotAudry MartinEmmanuelle MartinMaelle MartinPascale MartresVirginie MaximeOlivier MeunierElla-Pauline MeyerFerhat MezianiSébastien MoschiettoCéline MullerElodie Munier-MarionCaroline NeulierFrançois NicolasJacques-Yves NizouChristine PalittaMichel PascalOlivier PassouantRené-Gilles PatrigeonFrédérique PavillardSabine PeghaireChristophe PerdrixJean-Sebastien PetitJudith PibreWalter PicardSylvie PicaultSantiago Picos GilJérôme PillotPatrick PinaRémi PlattierLaurent PoironChristian PommierGaël PradelCristian PrelipceanPaul-Simon PugliesiVincent QueneeOlga RaposoEve RemySabine Reynaud DeforgesJean-Christophe RichardSylvie RicomeThomas RimmeleAdrien RobineAnne-Claude RocheLaetitia RohrGwenaël Rolland-JacobAdrien RoquesCatherine RougierJérôme RoustanMélanie Saint-LegerFaouzi SalibaDominique SechaudAmine Si-AliCatherine SimacGeorges SimonMichel SirodotVincent StoeckelPhilippe TagawaMarine TasleFabrice ThiollièreBenoit ThiphagneAurélie Thomas-HervieuFrançois TinturierAlexandre TonnelierAlexandre ToroDavid TranvanDominique TrivierGilles TrochéRémi TrussonLionel UrsuletMarie Laure ValdeyronCatherine ValletVanessa van RossemLaurence VasseMyriam VenelleChristine VenotAntoine Vieillard-BaronJean-François VincentMichel VitrisHussein YassineLassane ZanreCecile Zylberfajn
• Organismes : Hôpital Henry Gabrielle [CHU - HCL] Hôpital Henry Gabrielle [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] Centre International de Recherche en Infectiologie Hôpital Henry Gabrielle [CHU - HCL] Centre International de Recherche en Infectiologie Hôpital Henry Gabrielle [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] Centre International de Recherche en Infectiologie Hôpital Henry Gabrielle [CHU - HCL] Centre Hospitalier Lyon Sud [CHU - HCL] Centre International de Recherche en Infectiologie Hydrosciences Montpellier CHU de Montpellier, Service de Prévention des infections et de la Résistance
• Publié dans Critical Care le 31/10/2020

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Résumé : Background Candidemia is a high-risk complication among intensive care unit (ICU) patients. While selective digestive decontamination (SDD) has been shown to be effective in preventing ICU-acquired bacterial secondary infection, its effects on ICU-acquired candidemia (ICAC) remain poorly explored. Therefore, we sought to assess the effects of SDD on ICAC. Method Using the REA-REZO network, we included adult patients receiving mechanical ventilation for at least 48 h from January 2017 to January 2023. Non-parsimonious propensity score matching with a 1:1 ratio was performed to investigate the association between SDD and the rate of ICAC. Results A total of 94 437 patients receiving at least 48 h of mechanical ventilation were included throughout the study period. Of those, 3 001 were treated with SDD and 651 patients developed ICAC. The propensity score matching included 2 931 patients in the SDD group and in the standard care group. In the matched cohort analysis as well as in the overall population, the rate of ICAC was lower in patients receiving SDD (0.8% versus 0.3%; p = 0.012 and 0.7% versus 0.3%; p = 0.006, respectively). Patients with ICAC had higher mortality rate (48.4% versus 29.8%; p < 0.001). Finally, mortality rates as well as ICU length of stay in the matched populations did not differ according to SDD (31.0% versus 31.1%; p = 0.910 and 9 days [5–18] versus 9 days [5–17]; p = 0.513, respectively). Conclusion In this study with a low prevalence of ICAC, SDD was associated with a lower rate of ICAC that did not translate to higher survival.

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Fichiers liés : s13054-023-04775-1.pdf

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• Type de publi. : Autre publication
• Date de publi. : 15/12/2023
• Auteurs : Jérémy BousquetMaxence ChambonPhilippe ColemanRomélien ColavittiFanny GrabiasDenis JouveJean-François LafaixJean LessiEmmanuelle MarcLaurent SeurotLaurence VapailleLaetitia JanicotPierre Bourdon
• Organismes : Centre de Recherches et d’Études Administratives de Montpellier - EA 2038 Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Université d'Artois Université de Bretagne Sud Université de Tours Institut de Recherches sur l'Evolution de la Nation Et de l'Etat Centre de Recherche Droit et Territoire(s) - EA URCA - UFR Droit et science politique Université de Strasbourg Haute Autorité de Santé [Saint-Denis La Plaine] Université de Montpellier Institut de Recherches sur l'Evolution de la Nation Et de l'Etat CY Cergy Paris Université - Faculté de droit Université Paris 1 Panthéon-Sorbonne - UFR Science Politique CY Cergy Paris Université - Faculté de droit

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• Type de publi. : Article dans une revue
• Date de publi. : 15/12/2023
• Auteurs : Charles JaverliatPierre RaimbaudSophie VillenavePierre-Philippe ElstEliott ZimmermannMartin GuesneyMylène PardoenPatrick BaertGuillaume Lavoué
• Organismes : Origami Origami Origami Origami Origami Maison des Sciences de l’Homme Lyon Saint-Etienne Maison des Sciences de l’Homme Lyon Saint-Etienne Origami Origami
• Publié dans Expression sensible le 17/07/2024

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Résumé : En dressant un panorama des techniques existantes pour la capture et la restitution sensible en réalité virtuelle, cet article présente un état de l’art des techniques existantes, à la fois pour la capture et la restitution multisensorielle immersive. Il fournit également un exemple d’application concrète de ces technologies dans le cadre du projet Promess. Article complet : https://expression-sensible.fr/transmission-des-savoirs-sensibles-2

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• Type de publi. : Autre publication
• Date de publi. : 15/12/2023
• Auteurs : Jérémy BousquetMaxence ChambonPhilippe ColemanFanny GrabiasDenis JouveJean-François LafaixJean LessiEmmanuelle MarcLaurent SeurotLaurence VapailleLaetitia JanicotPierre Bourdon
• Organismes : Centre de Recherches et d’Études Administratives de Montpellier - EA 2038 Détection, évaluation, gestion des risques CHROniques et éMErgents (CHROME) - Nîmes Université Université d'Artois Université de Bretagne Sud Institut de Recherches sur l'Evolution de la Nation Et de l'Etat Centre de Recherche Droit et Territoire(s) - EA URCA - UFR Droit et science politique Université de Strasbourg Haute Autorité de Santé [Saint-Denis La Plaine] Université de Montpellier Institut de Recherches sur l'Evolution de la Nation Et de l'Etat CY Cergy Paris Université - Faculté de droit Université Paris 1 Panthéon-Sorbonne - UFR Science Politique CY Cergy Paris Université - Faculté de droit

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• Type de publi. : Article dans une revue
• Date de publi. : 14/12/2023
• Auteurs : Aboubakari NambiemaQuentin LisanJulien VaucherMarie-Cecile PerierPierre BoutouyrieNicolas DanchinFrédérique ThomasCatherine GuiboutGeoffroy SolelhacRaphaël HeinzerXavier JouvenPedro Manuel Marques-VidalJean‐philippe Empana
• Organismes : Paris-Centre de Recherche Cardiovasculaire Épidémiologie en Santé au Travail et Ergonomie
• Publié dans European Heart Journal le 30/10/2020

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Résumé : Background and aims - Evidence on the link between sleep patterns and cardiovascular diseases (CVDs) in the community essentially relies on studies that investigated one single sleep pattern at one point in time. This study examined the joint effect of five sleep patterns at two time points with incident CVD events. Methods - By combining the data from two prospective studies, the Paris Prospective Study III (Paris, France) and the CoLaus|PsyCoLaus study (Lausanne, Switzerland), a healthy sleep score (HSS, range 0-5) combining five sleep patterns (early chronotype, sleep duration of 7-8 h/day, never/rarely insomnia, no sleep apnoea, and no excessive daytime sleepiness) was calculated at baseline and follow-up. Results - The study sample included 11 347 CVD-free participants aged 53-64 years (44.6% women). During a median follow-up of 8.9 years [interquartile range (IQR): 8.0-10.0], 499 first CVD events occurred (339 coronary heart disease (CHD) and 175 stroke). In multivariate Cox analysis, the risk of CVD decreased by 18% [hazard ratio (HR) 0.82, 95% confidence interval (CI) 0.76-0.89] per one-point increment in the HSS. After a median follow-up of 6.0 years (IQR: 4.0-8.0) after the second follow-up, 262 first CVD events occurred including 194 CHD and 72 stroke. After adjusting for baseline HSS and covariates, the risk of CVD decreased by 16% (HR 0.84, 95% CI 0.73-0.97) per unit higher in the follow-up HSS over 2-5 years. Conclusions - Higher HSS and HSS improvement over time are associated with a lower risk of CHD and stroke in the community.

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Fichiers liés : ehad657.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2023
• Auteurs : Fabien RollotZoé UhryEmmanuelle DantonySandra VukusicMarc DebouverieEmmanuelle Le PageJonathan CironAurélie RuetJérôme de SèzeHélène ZéphirPierre M. LabaugeGilles DeferChristine Lebrun-FrenayThibault MoreauDavid-Axel LaplaudEric BergerPierre ClavelouJean PelletierEric ThouvenotOlivier HeinzlefJean-Philippe CamdessanchéFauvernier, M.Laurent RemontetEmmanuelle Leray
• Organismes : Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Santé publique France - French National Public Health Agency [Saint-Maurice, France] Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Hospices Civils de Lyon Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Adaptation, mesure et évaluation en santé. Approches interdisciplinaires Service de neurologie [CHRU Nancy] Service de Neurologie [CHU Rennes] Centre d'Investigation Clinique [Rennes] Institut Toulousain des Maladies Infectieuses et Inflammatoires Département Neurologie [CHU Toulouse] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Service de neurologie [Bordeaux] CIC Strasbourg Lille Neurosciences & Cognition - U 1172 CHU Montpellier = Montpellier University Hospital Service de Neurologie [CHU Caen] Service de Neurologie [CHU Nice] Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Service de Neurologie [CHRU Besançon] Neuro-Dol Service Neurologie [CHU Clermont-Ferrand] Hôpital de la Timone [CHU - APHM] Institut de Génomique Fonctionnelle Service de Neurologie [CHU Nimes] Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Service de Neurologie [CHU de Saint-Étienne] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Centre d'Investigation Clinique [Rennes] Recherche en Pharmaco-épidémiologie et Recours aux Soins Département Méthodes quantitatives en santé publique École des Hautes Études en Santé Publique Université de Rennes Arènes: politique, santé publique, environnement, médias Collectif de recherche handicap, autonomie et société inclusive Recherche sur les services et le management en santé
• Publié dans Neurology le 01/11/2020

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Résumé : Background and objectives - Determining whether multiple sclerosis (MS) causes death is challenging. Our objective was to contrast 2 frameworks to estimate probabilities of death attributed to MS (P) and other causes (P): the cause-specific framework (CSF), which requires the causes of death, and the excess mortality framework (EMF), which does not. Methods - We used data from the Observatoire Français de la Sclérose en Plaques (OFSEP, n = 37,524) and from a comparative subset where causes of death were available (4,004 women with relapsing-onset MS [R-MS]). In CSF, the probabilities were estimated using the Aalen-Johansen method. In EMF, they were estimated from the excess mortality hazard, which is the additional mortality among patients with MS as compared with the expected mortality in the matched general population. P values were estimated at 30 years of follow-up, (1) with both frameworks in the comparative subset, by age group at onset, and (2) with EMF only in the OFSEP population, by initial phenotype, sex, and age at onset. Results - In the comparative subset, the estimated 30-year P values were greater using EMF than CSF: 10.9% (95% CI 8.3-13.6) vs 8.7% (6.4-11.8) among the youngest and 20.4% (11.3-29.5) vs 16.2% (8.7-30.2) for the oldest groups, respectively. In the CSF, probabilities of death from unknown causes ranged from 1.5% (0.7-3.0) to 6.4% (2.5-16.4), and even after their reallocation, P values remained lower with CSF than with EMF. The estimated probabilities of being alive were close using the 2 frameworks, and the estimated P (EMF vs CSF) was 2.6% (2.5-2.6) vs 2.1% (1.2-3.9) and 18.1% (16.9-19.3) vs 26.4% (16.5-42.2), respectively, for the youngest and oldest groups. In the OFSEP population, the estimated 30-year P values ranged from 7.5% (6.4-8.7) to 24.0% (19.1-28.9) in patients with R-MS and from 25.4% (21.1-29.7) to 36.8% (28.3-45.3) in primary progressive patients, depending on sex and age. Discussion - EMF has the great advantage of not requiring death certificates, their quality being less than optimal. Conceptually, it also seems more relevant because it avoids having to state, for each individual, whether death was directly or indirectly caused by MS or whether it would have occurred anyway, which is especially difficult in such chronic diseases.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 12/12/2023
• Auteurs : Michel AractingiPierre-Alexandre LeziartThomas FlayolsJulien PerezTomi SilanderPhilippe Souères
• Organismes : Naver Labs Europe [Meylan] Équipe Mouvement des Systèmes Anthropomorphes Équipe Mouvement des Systèmes Anthropomorphes Équipe Mouvement des Systèmes Anthropomorphes Naver Labs Europe [Meylan] Naver Labs Europe [Meylan] Équipe Mouvement des Systèmes Anthropomorphes

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Résumé : The quadruped locomotion task is generally con- ditioned on a velocity command that is user-defined. However, certain features of the locomotion are not represented in this high-level definition of the task, e.g., swing feet height, step length and expended energy. Using reinforcement learning, many of these features can be determined by the reward function terms and scales that are often fixed. In this work, we propose a deep reinforcement learning (DRL) approach to learn control policies augmented with parameters that modify different aspects of the reward function and control setup which, in turn, result in variations of the locomotion. We can then define a hierarchical architecture where a high level policy infers the suitable parameters to complete a given task. We show that this setup makes it possible to learn more complex behaviours that can be adapted for different terrains and environments to ensure successful and efficient locomotion. We display our results by deploying the low-level parameterized policy on the MIT Mini-Cheetah quadruped.

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Fichiers liés : HRL_Loco-2.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 12/12/2023
• Auteurs : Pierre TrontinLokman BennaniJean-Mathieu SenonerPhilippe Villedieu
• Organismes : Laboratoire de Mecanique des Fluides et d'Acoustique DMPE, ONERA, Université de Toulouse [Toulouse] DMPE, ONERA, Université de Toulouse [Toulouse] DMPE, ONERA, Université de Toulouse [Toulouse]

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Résumé : To comply with certification rules, aircraft must demonstrate their operability in ice crystal icing conditions. This chapter is devoted to ice crystal icing and highlights its specifics compared to classical supercooled water icing. Dedicated models are proposed for the transport of particles, their impact on walls, and the accretion in crystal conditions. Their integration in 2-D and 3-D icing suites is presented. Preliminary validations of the models are presented for both glaciated and mixed-phase conditions as well as a first industrial application.

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