Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Pierre PouvreauJulien CoelhoCécile RumeauOlivier MalardRenaud GarrelJustin MichelChristian Adrien RighiniS. VergezRobin BaudouinVianney BastitJean-Paul MarieAude VillepeletAntoine Moya-PlanaPierre PhilouzeNicolas SaroulLaurence DigueAmaury DasteSophie RenardSylvain MoriniereFlorent CarsuzaaBenjamin VerillaudGilles PoissonnetPhilippe SchultzEsteban BrenetFrançois MouawadJuliette ThariatNoémie VulquinClaire CastainLudovic de GaboryCharles Dupin
• Organismes : Université de Bordeaux Sommeil, Addiction et Neuropsychiatrie [Bordeaux] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Nantes = Nantes University Hospital CHU Montpellier = Montpellier University Hospital Hôpital de la Conception [CHU - APHM] CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Centre Hospitalier Universitaire de Toulouse Hôpital Foch [Suresnes] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Rouen Centre Hospitalier Intercommunal de Créteil Département Anesthésie, Chirurgie et Interventionnel [Gustave Roussy] Hospices Civils de Lyon CHU Clermont-Ferrand Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Régional Universitaire de Tours Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Hôpital Lariboisière-Fernand-Widal [APHP] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Université de Strasbourg Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Régional de Lutte contre le Cancer François Baclesse [Caen] Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] CHU de Bordeaux Pellegrin [Bordeaux] Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Universitaire de Bordeaux Sommeil, Addiction et Neuropsychiatrie [Bordeaux]
• Publié dans EJSO - European Journal of Surgical Oncology le 22/10/2020

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Résumé : Objectives: Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive disease requiring multimodal treatment, and multiple new entities once included in the spectrum of SNUC, such as SWI/SNF-deficient carcinomas, are emerging. We aimed to provide new data regarding the role of chemotherapy and surgery and the prognostic factors of disease-free survival. Methods: This study was based on data from the REFCOR database and included patients with SNUC treated with curative intent from 2007 to 2021 across 22 centres in France. Results: A total of 80 patients were included in the analysis. Among the entire cohort, the 5-year disease-free survival (DFS) and overall survival (OS) rates were 58% and 63%, respectively. Of 100% of the patients treated with irradiation, 29% underwent surgery, 56% neoadjuvant chemotherapy (82% had either a partial or a complete response) and 76% chemoradiotherapy. No treatment modality was associated with a better OS or DFS, including surgery (p = 0.34). There was a trend for a better DFS for the patients treated with chemotherapy (neoadjuvant or concomitant, p = 0.062). Overall survival at 3 years was 58% for SWI/SNF deficient group and 86% for non deficient group (p = 0.14). The locoregional relapse rate without distant metastases was 21% in the exclusive radiotherapy group and 26% in the surgery group. Grade 3 or higher toxicities concerned 9%, 32% and 29% of patients for surgery, radiotherapy and chemotherapy respectively. Conclusion: In the management of localised SNUC among all patients treated with irradiation, surgery yielded no benefit, whereas the addition of chemotherapy tended to improve disease-free survival.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Saber Davide BarbarAbderrahmane BourredjemRémi TrussonAuguste DargentChristine BinquetJean-Pierre QuenotRaphaël Clere-JehlRomain HernuFlorent MontiniRémi BruyèreChristine LebertJulien BohéJulio BadieJean-Pierre EraldiJean-Philippe RigaudBruno LevyShidasp SiamiGuillaume LouisLila BouadmaJean-Michel ConstantinEmmanuelle MercierKada KloucheDamien Du CheyronGaël PitonDjillali AnnaneSamir JaberTherry van der LindenGilles BlascoJean-Paul MiraCarole SchwebelLoïc ChimotPhilippe GuiotMai-Anh NayFerhat MezianiJulie HelmsClaire RogerBenjamin Louart
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background This substudy of the randomized IDEAL-ICU trial assessed whether the timing of renal replacement therapy (RRT) initiation has a differential effect on 90-day mortality, according to the criteria used to diagnose acute kidney injury (AKI), in patients with early-stage septic shock. Methods Three groups were considered according to the criterion defining AKI: creatinine elevation only (group 1), reduced urinary output only (group 2), creatinine elevation plus reduced urinary output (group 3). Primary outcome was 90-day all-cause death. Secondary endpoints were RRT-free days, RRT dependence and renal function at discharge. We assessed the interaction between RRT strategy (early vs. delayed) and group, and the association between RRT strategy and mortality in each group by logistic regression. Results Of 488 patients enrolled, 205 (42%) patients were in group 1, 174 (35%) in group 2, and 100 (20%) in group 3. The effect of RRT initiation strategy on 90-day mortality across groups showed significant heterogeneity (adjusted interaction p = 0.021). Mortality was 58% vs. 42% for early vs. late RRT initiation, respectively, in group 1 ( p = 0.028); 57% vs. 67%, respectively, in group 2 ( p = 0.18); and 58% vs. 55%, respectively, in group 3 ( p = 0.79). There was no significant difference in secondary outcomes. Conclusion The timing of RRT initiation has a differential impact on outcome according to AKI diagnostic criteria. In patients with elevated creatinine only, early RRT initiation was associated with significantly increased mortality. In patients with reduced urine output only, late RRT initiation was associated with a nonsignificant, 10% absolute increase in mortality.

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Fichiers liés : 2023 Barbar et al., Differential.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Xiangzhuo LiuWigneron J.-P.Wolfgang WagnerFrédéric FrappartLei FanMariette VreugdenhilNicolas BaghdadiMehrez ZribiThomas JagdhuberShengli TaoXiaojun LiHuan WangMengjia WangXiaojing BaiB.G. MousaPhilippe Ciais
• Organismes : Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Vienna University of Technology = Technischen Universität Wien Interactions Sol Plante Atmosphère Southwest University [Chongqing] Vienna University of Technology = Technischen Universität Wien Territoires, Environnement, Télédétection et Information Spatiale Centre d'études spatiales de la biosphère Universität Augsburg [Deutschland] = University of Augsburg [Germany] = Université d'Augsbourg [Allemagne] Peking University [Beijing] Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Zhengzhou University Nanjing University of Information Science and Technology Al-Azhar University [Cairo, Egypt] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette]
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Active microwave measurements have the potential to estimate vegetation optical depth (VOD), an indicator related to vegetation water content and biomass. The Advanced SCATterometer (ASCAT) provides long-term C-band backscatter data at vertical-vertical (VV) polarization from 2007. So far, very few studies have considered retrieving VOD from this active sensor. This study presents a new publicly released global long-term and continuous (2007–2020) C-band VOD dataset retrieved from the ASCAT observations, named the ASCAT INRAE-BORDEAUX or ASCAT IB VOD product. The retrieval algorithm is based on the Water Cloud Model (WCM) including the Ulaby bare soil model. The algorithm takes advantage of a multi-temporal (MT) retrieval method relying on a cost function where constraints to the retrieved parameters are implemented and a reanalysis soil moisture (SM) dataset from ERA5-Land is used as an input. The performance of ASCAT IB VOD was evaluated by inter-comparing it with ASCAT Technische Universität Wien (TUW), the Advanced Microwave Scanning Radiometer 2 (AMSR2), and VOD Climate Archive (VODCA) VOD products (the last two products are estimated from passive microwave observations). Results showed that ASCAT IB VOD presented the highest spatial correlation with aboveground biomass (R ∼ 0.83) and with the Global Ecosystem Dynamics Investigation (GEDI) canopy height (R ∼ 0.84–0.85). In terms of temporal performance, ASCAT IB VOD had the highest correlation R values with leaf area index (LAI) and Normalized Difference Water Index (NDWI) in most parts of the globe from 2013 to 2018. This contrasts with AMSR2 VODs which correlated better with Normalized Difference Vegetation Index (NDVI). The new ASCAT-based VOD product on a global scale highlighted the potential benefit of combining active (namely ASCAT) and passive (namely AMSR2) VOD products for vegetation studies.

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Fichiers liés : 1-s2.0-S0034425723004017-am.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Rémi Nguyen VanSarah TubianaThomas de BrouckerCédric JosephCarine RoyMarie-Caroline MeyohasThierry PrazuckCatherine ChirouzeBruno HoenXavier DuvalMatthieu RevestBruno MourvillierMarie-Cécile PloyFrançois CaronPierre-Edouard BollaertOlivier GaillotMuhamed-Kheir TahaClaire PoyartStéphane BonacorsiFrancois VandeneschEmmanuelle CambauMarc LecuitAlain GravetBruno FrachetDaniel Levy BruhlFrançois RaffiMarie PreauNadia AnguelLaurent ArgaudSophie AristaLaurence Armand-LefèvreStéphanie BalavoineRégine BaraducGuilène BarnaudGuillaume BeraudLouis BernardGeorges BernarsDominique BerteiEmilie BessedeTyphaine Billard-PomarèsCharlotte BironStéphane BlandJulien BoileauPatrice BoubeauSandra BourdonAurore BousquetSophie BoyerAlexis Bozorg-GrayeliLaurent BretCédric BretonniereFrançois BricaireElsa BrocasMichel BrunJennifer BuretChristophe BurucoaJean CabalionMathieu CabonGuillaume CamusetChristophe CanevetAnne CarricajoBernard CastanEric CaumesCharles CazanaveAmélie ChabrolThibaut Challan-BelvalVanessa Chanteperdrix-MarillierChantal ChaplainCaroline Charlier-WoertherHélène ChaussadeCatherine ChirouzeBernard ClairJulien ColotJean-Marie ConilHugues CordelPhilippe CormierJoël CoussonPierrick CronierEric CuaAnne Dao-DubremetzSylvie DargereNicolas DegandSophie DekeyserDeborah DelauneEric DenesPierre-Francois DequinDiane DescampsElodie DesclouxJean-Luc DesmaretzJean-Luc DiehlJérôme DimetAurélien DinhLelia EscautClaude FabeFrédéric FaibisClara FlateauNathalie FonsaleEmmanuel ForestierNicolas FortineauAmandine Gagneux-BrunonCaroline GarandeauMagali GarciaDenis GarotStéphane GaudryFrançois GoehringerValérie Gregoire-FaucherMarine GrossetCamélia GubavuIsabelle GueitDominique GuelonThomas GuimardJérôme GuinardTahar HadouJean-Pierre HeleneSandrine HenardBenoit HenryAnne-Cécile HochartBruno HoenGabriela IllesSylvain JaffuelIrène JarrinFrançoise JaureguyMarie-Emmanuelle JuvinSamer KayalSolen KernéisIsabelle LamauryPhilippe LanotteEtienne LaurensHenri LaurichesseCécile Le BrunVincent Le MoingPaul Le TurnierHervé LecuyerSylvie LedruCéline LegrixAdrien LemaignenChantal LembleLudovic LemeeOlivier LesensMarion LevastClaire LhommetSilvija MalesEdith MalpoteGuillaume Martin-BlondelMatthieu MarxRaphael MassonOlivier MatrayAurore MbadiFrédéric MechaiGuillaume MellonAudrey MerensMarie Caroline MeyohasAdrien MichonJoy Mootien YoganadenDavid MorquinStéphane MoulyNatacha MrozekSophie NguyenYohan NguyenMaja OgielskaEric OziolBernard PageSolène Patrat-DelonIsabelle PatryAndré PechinotSandrine PicotDenys PierrejeanLionel PirothClaire PlassartPatrice PlessisLaurent PortelPatrice PoubeauMarie PoupardThierry PrazuckLuc QuaesaetAdriatsiferana RamanantsoaChristophe RappLaurent RaskineJosette RaymondMatthieu RevestAgnès RicheStéphanie Robaday-VoisinFrédéric RobinJean-Pierre RomaszkoFlorence RousseauAnne-Laure RouxCécile RoyerMatthieu SaadaDominique Salmon-CéronCarlo SaroufimJean-Luc SchmitManuela SebireChristine SegondsValérie Sivadon-TardyNathalie SoismierOlivia SonSimon SunderFlorence SuyDidier TandeJacques TankovicNadia ValinNicolas van GrunderbeeckEmmanuelle VaronRenaud VerdonMichel VergnaudVéronique Vernet-GarnierMagali VidalVirginie VitratDaniel VittecoqFanny VuottoIsabelle GorenneCédric LaouenanEstelle MarcaultFrance MentreBlandine PasquetCarine RoySarah Tubiana
• Organismes : ARN bactériens et médecine Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Infection, Anti-microbiens, Modélisation, Evolution Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique Université de Picardie Jules Verne Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Cohort of community-acquired bacterial meningitis in adults study group Modèles et méthodes de l'évaluation thérapeutique des maladies chroniques CHU Saint-Antoine [AP-HP] Centre Hospitalier Régional d'Orléans Centre d'investigation clinique Antilles-Guyane Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution Centre d'Investigation Clinique [Rennes] Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN bactériens et médecine Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Institut de Mathématiques de Bordeaux Centre Hospitalier Régional Universitaire de Nancy Physiopathologie moleculaire des infections microbiennes Barrières et Pathogènes Centre national de Référence des Streptocoques (CNR) Physiopathologie des inferctions extra-intestinales à Escherichia coli en pédiatrie AP-HP Hôpital universitaire Robert-Debré [Paris] Centre National de Reference des Staphylocoques Agents infectieux, résistance et chimiothérapie - UR UPJV 4294
• Publié dans European Journal of Clinical Microbiology and Infectious Diseases le 22/10/2020

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Résumé : Background: Little is known on headaches long-term persistence after bacterial meningitis and on their impact on patients' quality of life.Methods: In an ancillary study of the French national prospective cohort of community-acquired bacterial meningitis in adults (COMBAT) conducted between February 2013 and July 2015, we collected self-reported headaches before, at onset, and 12 months (M12) after meningitis. Determinants of persistent headache (PH) at M12, their association with M12 quality of life (SF 12), depression (Center for Epidemiologic Studies Depression Scale) and neuro-functional disability were analysed.Results: Among the 277 alive patients at M12 87/274 (31.8%), 213/271 (78.6%) and 86/277 (31.0%) reported headaches before, at the onset, and at M12, respectively. In multivariate analysis, female sex (OR: 2.75 [1.54-4.90]; p < 0.001), pre-existing headaches before meningitis (OR: 2.38 [1.32-4.30]; p < 0.01), higher neutrophilic polynuclei percentage in the CSF of the initial lumbar puncture (OR: 1.02 [1.00-1.04]; p < 0.05), and brain abscess during the initial hospitalisation (OR: 8.32 [1.97-35.16]; p < 0.01) were associated with M12 persistent headaches. Neither the responsible microorganism, nor the corticoids use were associated with M12 persistent headaches. M12 neuro-functional disability (altered Glasgow Outcome Scale; p < 0.01), M12 physical handicap (altered modified Rankin score; p < 0.001), M12 depressive symptoms (p < 0.0001), and M12 altered physical (p < 0.05) and mental (p < 0.0001) qualities of life were associated with M12 headaches.Conclusion: Persistent headaches are frequent one year after meningitis and are associated with quality of life alteration.

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Fichiers liés : latest.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Marie-Anne de BideranMathilde OyallonJean Philippe PerrinStéphane RenaudinPierre CorreHélios Bertin
• Organismes : Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Regenerative Medicine and Skeleton Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers
• Publié dans Journal of Stomatology, Oral and Maxillofacial Surgery le 25/10/2020

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Résumé : Functional genioplasty aims to achieve lip competence at rest and reduces lip pressure against the mandibular incisors. The purpose of this study was to describe the radiographic changes in alveolar bone of the mandibular incisors after functional genioplasty.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Nathalie JustPierre Marie ChevillardMartine BataillerJean-Philippe DuboisPascal VaudinDelphine PillonMartine Migaud
• Organismes : Physiologie de la reproduction et des comportements [Nouzilly] Danish Research Centre for Magnetic Resonance Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly] Physiologie de la reproduction et des comportements [Nouzilly]
• Publié dans Neuroscience le 24/10/2020

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Résumé : Most organisms on earth, humans included, have developed strategies to cope with environmental day-night and seasonal cycles to survive. For most of them, their physiological and behavioral functions, including the reproductive function, are synchronized with the annual changes of day length, to ensure winter survival and subsequent reproductive success in the following spring. Sheep are sensitive to photoperiod, which also regulates natural adult neurogenesis in their hypothalamus. We postulate that the ovine model represents a good alternative to study the functional and metabolic changes occurring in response to photoperiodic changes in hypothalamic structures of the brain. Here, the impact of the photoperiod on the neurovascular coupling and the metabolism of the hypothalamic structures was investigated at 3T using BOLD fMRI, perfusion-MRI and pro-ton magnetic resonance spectroscopy (1H-MRS). A longitudinal study involving 8 ewes was conducted during long days (LD) and short days (SD) revealing significant BOLD, rCBV and metabolic changes in hypothalamic structures of the ewe brain between LD and SD. More specifically, the transition between LD and SD revealed neg-ative BOLD responses to hypercapnia at the beginning of SD period followed by significant increases in BOLD, rCBV, Glx and tNAA concentrations towards the end of the SD period. These observations suggest longitudinal mechanisms promoting the proliferation and differentiation of neural stem cells within the hypothalamic niche of breeding ewes. We conclude that multiparametric MRI studies including 1H-MRS could be promising non-invasive translational techniques to investigate the existence of natural adult neurogenesis in-vivo in gyrencephalic brains.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Bernard CholleyMirela BojanBenoit GuillonEmmanuel BesnierMathieu MatteiBruno LevyAlexandre OuattaraNadir TaferClément DelmasDavid TononBertrand RozecJean-Luc FellahiPascal LimFrançois LabasteFrançois RoubilleThibaut CarubaPhilippe MauriatOlivier BarbotBerthomieu LaurentAnne-Marie BesselatBlanchart KatrienAdrien BougléPierre BourgoinCauseret ArnaudHélène CharbonneauMircea CristinarOlivier DesebbeVeldat EljeziThibaud GenetMaxime GrenierPierre-Grégoire GuinotStéphane LebelYael LevyFrançois LionJacques MansouratiStéphanie MarlièreAnne-Céline MartinAlexandre MebazaaUsman MohammadJacques MonseguNicolas NesselerIsabelle OrselÉtienne PuymiratMorgan RecherSabri SoussiVincent TroussardSabrina UhryXavier Zirphile
• Organismes : Hôpital Européen Georges Pompidou [APHP] Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis Hôpital Marie-Lannelongue Groupe Hospitalier Paris Saint-Joseph Centre Hospitalier Régional Universitaire de Besançon CHU Rouen Endothélium, valvulopathies et insuffisance cardiaque Service de Cardiologie [CHRU Nancy] Service de Réanimation Médicale [CHRU Nancy] Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases CHU de Bordeaux Pellegrin [Bordeaux] Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases REICATRA, Recherche et Enseignement en IC Avancée, Transplantation, Assistance Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Hôpital de la Timone [CHU - APHM] ITX-lab unité de recherche de l'institut du thorax UMR1087 UMR6291 Cardiovasculaire, métabolisme, diabétologie et nutrition Institut Mondor de Recherche Biomédicale Pôle Anesthésie Réanimation [CHU de Toulouse] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Européen Georges Pompidou [APHP] Hôpital Haut-Lévêque [CHU Bordeaux] Université de Bordeaux Centre Hospitalier Saint Jean de Perpignan CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Université de Caen Normandie Hôpital de la Cavale Blanche - CHRU Brest Optimisation des régulations physiologiques
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background Following the results of randomized controlled trials on levosimendan, French health authorities requested an update of the current use and side-effects of this medication on a national scale. Method The France-LEVO registry was a prospective observational cohort study reflecting the indications, dosing regimens, and side-effects of levosimendan, as well as patient outcomes over a year. Results The patients included ( n = 602) represented 29.6% of the national yearly use of levosimendan in France. They were treated for cardiogenic shock ( n = 250, 41.5%), decompensated heart failure ( n = 127, 21.1%), cardiac surgery-related low cardiac output prophylaxis and/or treatment ( n = 86, 14.3%), and weaning from veno-arterial extracorporeal membrane oxygenation ( n = 82, 13.6%). They received 0.18 ± 0.07 µg/kg/min levosimendan over 26 ± 8 h. An initial bolus was administered in 45 patients (7.5%), 103 (17.1%) received repeated infusions, and 461 (76.6%) received inotropes and or vasoactive agents concomitantly. Hypotension was reported in 218 patients (36.2%), atrial fibrillation in 85 (14.1%), and serious adverse events in 17 (2.8%). 136 patients (22.6%) died in hospital, and 26 (4.3%) during the 90-day follow-up. Conclusions We observed that levosimendan was used in accordance with recent recommendations by French physicians. Hypotension and atrial fibrillation remained the most frequent side-effects, while serious adverse event potentially attributable to levosimendan were infrequent. The results suggest that this medication was safe and potentially associated with some benefit in the population studied.

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Fichiers liés : 2023 Chollet et al., Overview of.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Thierno Mamadou MillimonoAlioune CamaraGustave MabiamaMamady DafféFarid BoumedienePierre-Marie PreuxJean-Claude DesportPhilippe FayemendyPierre Jésus
• Organismes : Epidémiologie des Maladies Chroniques en zone tropicale Université Gamal Abdel Nasser de Conakry Université Gamal Abdel Nasser de Conakry Université de Douala Université Gamal Abdel Nasser de Conakry Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle Epidémiologie des Maladies Chroniques en zone tropicale Nutrition Resources Center CERENUT, Isle
• Publié dans Scientific Reports le 26/10/2020

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Résumé : Abstract Aging of the Guinean population is a public health concern for the coming years, and the nutritional status of older people is virtually unknown. We also know that this population is growing and that undernutrition and obesity can affect the health of older adults. This study aimed to assess the nutritional status of older people in the general population of Guinea and its associated factors. A representative cross-sectional survey was conducted using sociodemographic, clinical, and anthropometric data (weight and height). Oral status was assessed by using the University of Nebraska Oral Status Scale. Visual acuity was assessed using the Monoyer scale. The standardized prevalence ratio (SPR) of the nutritional status was calculated for each region. The sample included 1698 subjects with a mean BMI of 22.6 ± 4.3 kg/m 2 . A total of 50.3% had impaired oral status and 20.3% had moderately to severely impaired visual acuity. The prevalence of undernutrition was 14.4% and of obesity 5.7%. Differences in the prevalence of nutritional status were found between regions, with an SPR > 1 for undernutrition in the Labé region (SPR 1.9, 95% CI = 1.5–2.5) and for obesity in the Conakry and Kindia regions (SPR of 2.90, 95% CI = 2.0–4.05 and 2.32, 95% CI = 1.5–3.3, respectively). In Guinea, The prevalence of nutritional disorders was approximately 20%. Screening and management of the health and nutritional status of older adults should be a national priority, and management should be adapted to each region of the country.

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Fichiers liés : s41598-023-42494-3.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Matthieu JabaudonAlexandra GenevrierSamir JaberOlivier WindischStéphanie BulyezPierre-François LaterreEtienne EscudierAchille SossouPhilippe GuerciPierre-Marie BertrandPierre-Eric DaninMartin BonnassieuxLeo BühlerClaudia Paula HeideggerRussell ChabanneThomas GodetLaurence RoszykVincent SapinEmmanuel FutierBruno PereiraJean-Michel ConstantinElodie CaumonJulien AmatDominique MorandRenaud GuérinSébastien PerbetBenjamin RieuSophie CayotChristian ChartierCamille VerlhacChristine RolhionJustine BourdierBernard CosserantRaiko BlondonnetJean-Baptiste JoffredoThomas CostillesDamien BouvierLise BernardJean-Etienne BazinLaurence RoszykLydie Marie-AnneRaphaël GiraudAnnick PuchoisCyril BoronadMarine AgulloBoris JungGérald ChanquesCécile SpiritoMarion MonninAlbert PradesMoussa CisseAnne VerchereClaudine GniadekFouad BelafiaDaniel VerzilliJulie CarrAudrey de JongYannael CoiselJean-Marc DelayMatthieu ConseilMarie GonzalezDelphine RosantMichel PrevotBernard ClaudFrançois BrenasLassane ZanrePhilippe BrayHélène RieraEmilie Gadea-DeschampsPablo MassanetCaroline BoutinSaber BarbarDavid-Paul de BrauwereSerge LumbrosoAmélie MaurinSophie LloretLaurent MullerClaire RogerJean-Yves LefrantLoubna ElotmaniAudrey AyralSuzanne RenardNadège BouskilaGaspard BeauneMagali Farines-RaffoulMarie LeboucAuguste DargentThomas CrozonJulien ClauzelMarinne Le CoreThomas Rimmelé
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Findings from preclinical studies and one pilot clinical trial suggest potential benefits of epidural analgesia in acute pancreatitis. We aimed to assess the efficacy of thoracic epidural analgesia, in addition to usual care, in improving clinical outcomes of intensive care unit patients with acute pancreatitis. Methods A multicenter, open-label, randomized, controlled trial including adult patients with a clinical diagnosis of acute pancreatitis upon admission to the intensive care unit. Participants were randomly assigned (1:1) to a strategy combining thoracic epidural analgesia and usual care (intervention group) or a strategy of usual care alone (control group). The primary outcome was the number of ventilator-free days from randomization until day 30. Results Between June 2014 and January 2019, 148 patients were enrolled, and 135 patients were included in the intention-to-treat analysis, with 65 patients randomly assigned to the intervention group and 70 to the control group. The number of ventilator-free days did not differ significantly between the intervention and control groups (median [interquartile range], 30 days [15–30] and 30 days [18–30], respectively; median absolute difference of − 0.0 days, 95% CI − 3.3 to 3.3; p = 0.59). Epidural analgesia was significantly associated with longer duration of invasive ventilation (median [interquartile range], 14 days [5–28] versus 6 days [2–13], p = 0.02). Conclusions In a population of intensive care unit adults with acute pancreatitis and low requirement for intubation, this first multicenter randomized trial did not show the hypothesized benefit of epidural analgesia in addition to usual care. Safety of epidural analgesia in this setting requires further investigation. Trial registration : ClinicalTrials.gov registration number NCT02126332 , April 30, 2014.

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Fichiers liés : 2023 Jabaudon et al., Thoracic.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Grégoire MarretStéphane TemamMaud KamalCaroline EvenJean-Pierre DelordCaroline HoffmannGilles DolivetOlivier MalardJérôme FayetteOlivier CapitainS. VergezLionel GeoffroisFrédéric RollandPhilippe ZrounbaLaurent LaccourreyeEsma Saada-BouzidNicolas AideValérie BénaventJerzy KlijianenkoConstance LamyElodie GirardSophie VacherJulien Masliah-PlanchonLeanne de KoningVincent PuardEdith BorcomanMarta JimenezIvan BiècheJocelyn GalChristophe Le Tourneau
• Organismes : Institut Curie [Paris] Département de radiothérapie [Gustave Roussy] Cancer Campus Département de cancérologie cervico-faciale [Gustave Roussy] Département de médecine oncologique [Gustave Roussy] Institut Curie [Paris] Département de radiothérapie [Gustave Roussy] Cancer Campus Département de cancérologie cervico-faciale [Gustave Roussy] Département de médecine oncologique [Gustave Roussy] Institut Universitaire du Cancer de Toulouse - Oncopole Oncopole Claudius Regaud Immunité et cancer Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Centre de Recherche en Automatique de Nancy Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Institut de Cancérologie de l'Ouest [Angers/Nantes] Institut Universitaire du Cancer de Toulouse - Oncopole Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] CRLCC René Gauducheau Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Cytokines : structure, signalisation et prolifération tumorale Institut de Recherche sur le Cancer et le Vieillissement Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Laboratoire International Associé Réponse des Organismes et Populations face au Stress Environnemental - Université Côte d’Azur - Centre Scientifique de Monaco Centre Scientifique de Monaco Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers UNICANCER Immunité et cancer Institut Curie [Paris] Département de radiothérapie [Gustave Roussy] Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] Institut Curie [Paris] UNICANCER Institut Curie [Paris] Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe
• Publié dans Scientific Reports le 26/10/2020

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Résumé : There is no strong and reliable predictive biomarker in head and neck squamous cell carcinoma (HNSCC) for EGFR inhibitors. We aimed to identify predictive and pharmacodynamic biomarkers of efficacy of afatinib, a pan-HER tyrosine kinase inhibitor, in a window-of-opportunity trial (NCT01415674). Multi-omics analyses were carried out on pre-treatment biopsy and surgical specimen for biological assessment of afatinib activity. Sixty-one treatment-naïve and operable HNSCC patients were randomised to afatinib 40 mg/day for 21–28 days versus no treatment. Afatinib produced a high rate of metabolic response. Responders had a higher expression of pERK1/2 ( P = 0.02) and lower expressions of pHER4 ( P = 0.03) and pRB1 ( P = 0.002) in pre-treatment biopsy compared to non-responders. At the cellular level, responders displayed an enrichment of tumor-infiltrating B cells under afatinib ( P = 0.02). At the molecular level, NF-kappa B signaling was over-represented among upregulated genes in non-responders ( P < 0.001; FDR = 0.01). Although exploratory, phosphoproteomics-based biomarkers deserve further investigations as predictors of afatinib efficacy.

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Fichiers liés : Randomized phase II study of preoperative afatinib in untreated head and neck cancers predictive and pharmacodynamic biomarkers of activity.pdf

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