Philippe JEAN-PIERRE

---

• Type de publi. : Rapport
• Date de publi. : 01/12/2023
• Auteurs : Florence GuillotPhilippe PergentAdeline BéaJean CataloCharles PeytavieJean SoulatSophie CornardeauMarie-Louise BouetFrancis DieulafaitRadiocarbon Poznan LaboratoryPierre Bordas
• Organismes : Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives Centre Michel de Boüard - Centre de recherches archéologiques et historiques anciennes et médiévales Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Institut national de recherches archéologiques préventives

---

Fichiers liés : PCR+FP Penne 2023.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Brad RovinJonathan BarrattHiddo HeerspinkCharles AlpersStewart BielerDong-Wan ChaeUlysses DivaJürgen FloegeLoreto GesualdoJula InrigDonald KohanRadko KomersLaura Ann KooiengaRichard LafayetteBart MaesRobert MałeckiAlex MercerIrene NoronhaSe Won OhChen Au PehManuel PragaPriscila PreciadoJai RadhakrishnanMichelle RheaultWilliam RoteSydney TangVladimir TesarHoward TrachtmanHernán TrimarchiJames TumlinMuh Geot WongVlado PerkovicIsabella AbbascianoCatarina AbrantesSimone AccarinoSharon AdlerAnnika AdobergRouzbeh AfsariSyeda AhmadJafar AhmedWooin AhnBamidele AjayiDariusz AksamitSaif Al ChalabiEric AlamartineBassam AlchiMohammad AliRoberta AliottaSalem AlmaaniCatarina AlmeidaEdgar AlmeidaFrancisco de la Prada AlvarezPatricia AlvesFrancesca AnneseGerald AppelAlberto Ortiz ArduanMaria ArenaMarta Calvo ArevaloDariush ArfaaniaCarlos AriasEmma Calatayud AristoyEgle AsakieneSarah AshleyAli AssefiAlba AtenzaAsta AuerbachHanna Augustyniak-BartosikMonroy AvellaJonathan Ayling-SmithIsabelle AyoubChristine AyvazyanRocco BaccaroAsha BaileyBruce BakerSaravanan BalamuthusamyJose BallarinRui BarataJerko BarbicDunja BarisicJonathan BarrattJose Carlos de Jesus BarretoClara BarriosMirco BelingheriAnna BenesovaAna Avila BernabeuWanja BernhardtShamik BhadraLuigi BianconeAnne BlanchardElena BoaglioDavide BolignanoAndrew BombackGustavo Andres Useche BonillaMonica BordoliBhadran BoseNeil BoudvilleDonald BrandonDonald BrandonKaren BrownChristian BroyetThomas BucknallAlexandre BuffetInga Arune BumblyteManuel BurdeseNatalia Allende BurgosNatalia Allende BurgosLaure BurguetStephane BurteyMartin BuschFigen CakirogluVictoria CampbellPietro CanettaFlavia CapaccioJuan CarbonellFilipa CardosoClara Garcia CarroRobert CarrollPierre-Louis CarronNazareno CarulloMatthias CassiaDawn CasterBelen Vizcaino CastilloDavide CatucciAndrea CavalliDong-Wan ChaeAron ChakeraDoris ChanGary Chi Wang ChanAnthony Ting Pong ChanLai Wan ChanJae Hyun ChangMing-Shan ChangFiona ChapmanChaim CharytanAsghar ChaudhryMelissa CheethamCheng-Hsu ChenHsin-Yu ChenChien-Liang ChenHung-Yuan ChenHung-Chun ChenLeila ChenineSiu Fai CheungChee Kay CheungNoemie Chiche-JourdeHsien-Fu ChiuYen-Ling ChiuYi-Wen ChiuIan ChiuHoon Young ChoiKang-Ju ChouParamit ChowdhuryPradip ChowdhuryConstantina ChrysochouChukwuma ChukwuKa Yeong ChunWookyung ChungDominik CieniawskiGuillaume ClaissePhilip ClaytonCatalina Martín ClearyNisha ClementToby CoatesChiara CognoLoredana CollaMichael CollinsMarco ColucciChristian CombeNicolino ComiRoderick ComunaleGabriel ContrerasBruce CooperGaia CoppockAna Cortesão CostaStefano CostanziMario CozzolinoSusan CrailLiliana CunhaElizabeth CurryTiane DaiErica DainaSam DaneshvariIndranil DasguptaLouise DasilvaRobert DavidsonAine Maire de BhailisValérie de PrécigoutMarc DecupereYahsou DelmasFrancesca DeodatoNeeraj DhaunAjay DhaygudeRanjit DhelariaFederica Di MaioMaria Angeles Goicoechea DiezhandinoZivka DikaMiriana DinicIan DittmerMirela DobreGabriel DoctorGabriele DonatiPeter DoubelNicole DouthitDiliana DraganovaYelena DrexlerMartin DrinkovicKlara DrinovskaCaroline DudreuilhClement DumondIvan DurlenBertrand DussolMontserrat Diaz EncarnacionZoltan EndreJorge EnriqueYusuf EqbalJonathan ErlichVittoria EspositoCiro EspositoFaisal FakihHua-Chang FangAna FarinhaAaron FeardayJoana de Sousa Soares FelgueirasElzbieta FelicjanczukJoão Carlos FernandesSara FernandesAdriana FernandesJose Luño FernandezVictor FernandezMangalee FernandoAna Carolina FigueiredoEric FirreJürgen FloegeOliver FlossmannLauren FloydNuno FonsecaJose Nuno de Almeida Agapito FonsecaCeline FooteSuzanne ForbesAngel ForcenAlessia FornoniDavid FouassierIan FraserKa Shun Samuel FungMonica FurlanoTeresa FurtadoRajdeep GadhRoxane GaissetMartin GallagherJoana GameiroMuralikrishna GangadharanFabiola Alonso GarciaOlga Gracia GarciaGunjan GargCyril GarrousteArchana GautamAbdallah GearaColin GeddesLana GellineoMichael GermainLoreto GesualdoFarid GhalliFrancesco GiaroniHarold GilesAlastair GilliesAna Vilar GimenoAnnette GirardetJeffrey GlazeTze GohMario GoisChristopher GoldsmithElena GomaAna Marta GomesLuis Pedro Falcao GoncalvesSara GoncalvesJulita Gontarek-KacprzakCarlos GonzalezArun GopuNayan GowdaNicholas GrayBarbara GrecoHeather GreenClarisse GrezeSian GriffinSecundino Cigarran GuldrisUrsula Verdalles GuzmanJeffrey Tsun Kit HaAmanda HallPatrick HamiltonSeung Hyeok HanRobert HawsAshik HayatLauren HeathSven HeinrichsAndrew HendersonAmy HendersonElizabeth HendrenAnne-Elisabeth HengSalia Virxinia Pol HeresJohann Konstantin HerfurthEvangelina Merida HerreroTzung-Yo HoJonathan HoganBernd HohensteinPeter HollettIvica HorvaticBang-Gee HsuChia-Tien HsuChih-Yang HsuShih-Ping HsuChien-Wei HuangAmy HudsonChi-Chih HungShang-Jyh HwangDaw-Yang HwangYoung Youl HyunMadis IlmojaGeorgina IrishRadu JacobSadia JahanArunima JainSofie JamarAnna JanderHye Ryoun JangCatherine JankoMeg JardinePiotr JaskowskiGuillaume JeantetBojan JelakovicJunseok JeonJong Cheol JeongShilpanjali JesudasonArksarapuk JittiratSang-Kyung JoRachel JonesNarae JooSofia JorgeBruce JulianJiyong JungPraveena JyothinagaramJigar KadakiaFahameedah KamalDurga KanigicherlaSandra KaranovicAlexandre KarrasTheodoros KasimatisMohamad KassemSiddhartha KattamanchiChristopher KellerDubravka Trajbar KentricChristiane KettnerKassem KhalilDana KimSe Joong KimYeong Hoon KimYunmi KimHyung Wook KimSunggyun KimJwa-Kyung KimAejin KimMyung-Gyu KimCassandra KimberKathryn KlammAnnegret KochEric KoesterKulli KolvaldSui KonLaura Ann KooiengaSradha KotwalMagdalena KrajewskaKarolina KratkaAnoushka KrishnanRathika KrishnasamyThilo KruegerIvan KruljacSimone KulkaUlrich KunzendorfMei-Chuan KuoHung-Tien KuoSheng KuoLorraine Pui Yuen KwanNorbert KwellaBogna KwellaKay KyawAurore LabatRichard LafayetteMark LagattaChi Kwan Darwin LamMark LambieCamille LanaretFarah LatifMargo LauteWai Ping LawSarah LawmanMercedes Salgueira LazoHajeong LeeMoon Hyoung LeeKyu-Beck LeeHyung-Seok LeeJungeun LeeHyun Hee LeePo-Tsang LeeLiisi LeisWim LemahieuJanson LeungYan LiDavina Ngoi Wah LieHoward LiflandKadri LilienthalWai LimMonica LimardoMarine LivrozetSelena LonghiDaniela LopesJose Antonio LopesNathan LordeGrant LuxtonMingyao MaMachaiah MadhriraPhillip MadoniaBart MaesKumaradevan MahadevanAmar MahdiEamon MahdiNicolas MaillardDita MaixnerovaKarolina Majstorovic BaracRobert MaleckiThomas MalfaitSilvia MalvicaSreedhar MandayamPaul ManleyNick MansfieldCarmelita MarcantoniChristophe MariatTamara Malek MarinLida Maria Rodas MarinPatrick MarkJoana MarquesEduardo Gutierrez MartinezStacy MartinezCatherine MassetIngrid MassonAmanda MatherThida Maung Maung MyintValentin MayetKieran MccaffertyEllen MccarthyStephen McdonaldKerri McgrealKellyn McmahonAndrew McnallyEmily McquarrieAllyson MedinaGert MeeusKshama MehtaElder MendozaMaria MenezesJerry MengPiergiorgio MessaAna MessiasPrzemyslaw MiarkaMarius MiglinasIvana MikacicAshraf MikhailMartina MilicevicRaffi MinasianMarcus MoellerHesham MoheyJavad MojarrabMaggie Ming Yee MokEduardo Parra MoncasiMartial MoonenWenceslao Adrian Aguilera MoralesEduardo Verde MorenoAntolina MorenoAdam MorrisDimitrios MoutzourisMercedes Gonzalez MoyaSimon MuchaMichela MusolinoPietro NapodanoAna NatarioLavinia NegreaBradley NelsonBrendon NeuenBritt NewsomeKit Chung Jack NgThu NguyenViet NguyenClementine NicoloMartin NitschkeEuan NobleEuan NobleFernando NolascoEmma O'LoneAdriana Sierra OchoaKook-Hwan OhSewon OhPedro OkohSara OmbeletMichelle O'ShaughnessyShih-Hsiang OuDavid PackhamAparna PadiyarMei-Fen PaiIrene Agraz PamplonaSzu-Yu PanBhavna PandyaFederica PapadiaClara PardinhasNishita ParikhSamir ParikhHyeong Cheon ParkJung Tak ParkLucia ParreiraPatrizia PasseriniRamachandra PatakMargret PateckiRajan PatelJusmin PatelMeera Patel SutharGemma PatellaArtashes PatrikyanDrasko PavlovicWilliam PaxtonChen PehYonatan PelegJosep Miquel Blasco PelicanoYu-Sen PengManuel Pereira de VicenteJonay Pantoja PerezErika PerezAna Perez de JoseMaría Vanessa Pérez GómezLeticia Perez LlunaUsha PeriNorberto PericoCarole PhilipponnetElaine PhuaJulia PielUnnikrishnan PillaiHelen PilmoreDjuro PlavljanicMercedes Velo PlazaCarol PollockArvind PonnusamySerena PontiThomas PowellNishigandha PradhanRaul Fernandez PradoIngrid PrkacinRishi PruthiDan PughSarah QuinnLuis QuintanaLathika RaakeshKannaiyan RabindranathLuc RadermacherJai RadhakrishnanOmar Sherin Ibrahim RagyRitesh RaichoudhuryMario RaimundoPaolo RandoneMona RazavianHelmut ReichelMarina ReisGiuseppe RemuzziAnnie ReynoldsAnna RicchiutoIvon Maritza Bobadilla RicoClaire RigothierAngus RitchieMaria Antonieta Azancot RiveroDana RizkHan RoAlfred RodriguezEva Rodriguez GarciaSimon RogerMohammad RonyMai RosenbergStephane RoueffBrad RovinSarah RoxburghMario RuizHelena Marco RusinolIvan RychlikHelena SáTania SalehiMaria Dolores Sánchez de la NietaSilja SandenLina SantockienePatricia Valerio SantosIara da Silva SantosMari SargsyanFranziska SarnowSebahat SatEwa SatoraAna SavukMatthew SayerGeorg SchlieperMandy SchlosserHans Schmidt-GuertlerOlivier SchockaertKevin SchulteLisa SchulzHaresh SelvaskandanDavid SempleShaundeep SenElviira SeppetAntonio Galan SerranoJean-Emmanuel SerreAngel SevillanoSapna ShahYvonne ShenBrittany SheridanKai-Hsiang ShuFord SightlerSónia SilvaArnold SilvaSmeeta SinhaAmanda SiriwardanaZvonimir SitasCarmen SivoPeter SizelandCathylee SlyPriscilla SmithBrian SnowElsa Sofia Quadrado SoaresAndrea SolazzoElena Gutierrez SolisLaurence SolomonYoung Rim SongHelena SousaBruce SpinowitzElizabeth StallworthyEleni StamellouMalgorzata StanczykStefanie StangenbergMarija StankovicAsta StankuvieneEmma Diletta SteaTomasz StomporJoshua StorrarJames SullivanWladyslaw SulowiczIrina SuyumovaCheuk Chun SzetoEsther TamaritEddie TanMay TanSydney Chi Wai TangHon TangCatarina TeixeiraKadri TellingNatalia Ramos TerradesVladimir TesarDidem TezÉric ThervetDamien ThibaudinMark ThomasNikhil ThyagarajanMarcin TkaczykMassimo TorreggianiMatias TrilliniShang-Feng TsaiWan-Chuan TsaiJer-Chia TsaiPo-Yu TsengJames TumlinKuei-Ting TungAngus TurnbullSuneel UdaniJana UhlinovaKristin UntFederica UrciuoloAn VanackerBert VandewieleAlvaro VazKristi VeermaeLiesbeth ViaeneAlvita VickieneSara ViganoMaria Antonia Munar VilaEswari VilayurCaridad Martinez VillanuevaCristina Medrano VillarroyaAlejandro Soria VillenVeronica ViramontesCaterina VitaDunja VujcicMona WahbaSusan WanChih-Hsien WangXavier WarlingGerald WatersJane WaughLea WeilandStefan WeinerThomas WeinreichStephan Christian WerthOlivia WickensVidu WijeratneKaren WilderLisa WillcocksAllister WilliamsAgata WiniarskaNikolaus WirtzLothar WolfGunter WolfMuh Geot WongYick Hei WongSze Ho Sunny WongBiruh WorkenehMing-Ju WuHon-Yen WuRoger WyndhamJihyun YangJu-Yeh YangChii YeapKa Fai YimKenneth YongTae-Hyun YooSonguk YoonTung-Min YuTak Tai Andrew YueMichel ZakariUrte ZakauskienePhilippe ZaouiJustyna ZbrzezniakDorota ZielinskaCarlotta Federica Zizzi
• Organismes : The Ohio State University [Columbus] University of Leicester University of Groningen [Groningen] University of New South Wales [Sydney] KI Editorial Board Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro Division of Nephrology Stanford School of Medicine [Stanford] Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias Service Néphrologie, Hémodialyses [CHU Clermont-Ferrand]
• Publié dans The Lancet le 02/11/2020

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Antoine MilhemFrédéric AnselmeAntoine da CostaSélim AbbeyJacques MansouratiHugues BaderPierre-François WinumNicolas BadencoPhilippe MauryAntoine DompnierDipen ShahNicolas JohnerJérôme TaiebJulien BertrandFrédéric TréguerMathieu AmelotPierre IngrandCaroline Allix-Béguec
• Organismes : Hôpitaux La Rochelle Ré Aunis [Groupe hospitalier littoral Atlantique] Service de Cardiologie [CHU Rouen] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital privé du Confluent [Nantes] Optimisation des régulations physiologiques Centre Hospitalier Régional Universitaire de Brest Centre hospitalier de Pau Centre Hospitalier Universitaire de Nîmes Institut de cardiologie [CHU Pitié-Salpêtrière] Institut des Maladies Métaboliques et Casdiovasculaires Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Centre Hospitalier d'Aix en Provence [Aix-en-Provence] Centre hospitalier régional de Metz-Thionville Clinique Saint-Joseph de Trélazé [France] Centre Hospitalier Le Mans (CH Le Mans) Université de Poitiers = University of Poitiers CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Hôpitaux La Rochelle Ré Aunis [Groupe hospitalier littoral Atlantique]
• Publié dans JACC: Clinical Electrophysiology le 31/10/2020

---

Résumé : BACKGROUND: In a preliminary study in patients hospitalized for catheter ablation of atrial fibrillation (AF), the atrial thrombus exclusion (ATE) score (stroke, hypertension, heart failure, and D-dimers >270 ng/mL) was developed to rule out the diagnosis of intra-atrial thrombus, with a negative predictive value (NPV) of 100%, and to avoid performing transesophageal echocardiography (TEE). OBJECTIVES: The present study was designed to prospectively confirm the NPV of the ATE score in an independent population. METHODS: Consecutive patients hospitalized for catheter ablation of AF or left atrial tachycardia (LAT) were prospectively enrolled in a multicenter study. D-dimer levels were measured within 48 hours before ablation. An ATE score of 0 was considered predictive of no thrombus. TEE was routinely performed at the beginning or just before the ablation procedure. The primary endpoint was the presence of atrial thrombus diagnosed by TEE. RESULT: The analysis included 3,072 patients (53.3% paroxysmal AF, 36.7% persistent AF, and 10% LAT). A thrombus was detected in 29 patients (0.94%; 95% CI: 0.63%-1.35%), all on appropriate anticoagulant therapy. An ATE score of 0 was observed in 818 patients (26.6%), and the sensitivity, specificity, positive predictive value, and NPV were 93.1%, 26.8%, 1.2%, and 99.8%, respectively. Follow-up of the false negative patients revealed the persistence of chronic organized thrombi. CONCLUSIONS: In patients hospitalized for catheter ablation of AF or LAT, the ATE score identifies a population at very low risk for atrial thrombus. In consultation with the patient, the cardiologist may consider not performing a preoperative TEE in case of an ATE score of 0.

---

Fichiers liés : Extralucid_manuscript.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 30/11/2023
• Auteurs : Stephan EhrmannFrançois BarbierJulien DemiselleJean-Pierre QuenotJean-Etienne HerbrechtDamien RouxJean-Claude LacheradeMickaël LandaisPhilippe SeguinDavid SchnellAnne VeinsteinPhilippe GouinSigismond LasockiQin LuGaëtan BeduneauMartine FerrandiereGaëtan PlantefèveClaire Dahyot-FizelierNader ChebibEmmanuelle MercierNathalie Heuzé-Vourc’hRenaud RespaudNicolas GrégoireDenis GarotMai-Anh NayFerhat MezianiPascal AndreuRaphaël Clere-JehlNoémie ZucmanMarie-Ange AzaïsMarjorie Saint-MartinCharlotte Salmon GandonnièreDalila BenzekriHamid MerdjiElsa Tavernier
• Organismes : Centre d’Etude des Pathologies Respiratoires [Tours] Centre d’Investigation Clinique [CHRU Tours] Centre Hospitalier Régional d'Orléans Nanomédecine Régénérative Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Hôpital de Hautepierre [Strasbourg] Hôpital Louis Mourier - AP-HP [Colombes] Institut Necker Enfants-Malades Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier d'Angoulême Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Archéologies et Sciences de l'Antiquité Centre Hospitalier Universitaire d'Angers CHU Pitié-Salpêtrière [AP-HP] Groupe de Recherche sur le Handicap Ventilatoire CHU Rouen Centre Hospitalier Régional Universitaire de Tours Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Hôpital de la Croix-Rousse [CHU - HCL] Université Claude Bernard Lyon 1 Centre Hospitalier Régional Universitaire de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Centre d’Investigation Clinique [CHRU Tours] methodS in Patients-centered outcomes and HEalth ResEarch
• Publié dans New England Journal of Medicine le 29/10/2020

---

Résumé : Background: Whether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear. Methods: In this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive inhaled amikacin at a dose of 20 mg per kilogram of ideal body weight once daily or to receive placebo for 3 days. The primary outcome was a first episode of ventilator-associated pneumonia during 28 days of follow-up. Safety was assessed. Results: A total of 850 patients underwent randomization, and 847 were included in the analyses (417 assigned to the amikacin group and 430 to the placebo group). All three daily nebulizations were received by 337 patients (81%) in the amikacin group and 355 patients (83%) in the placebo group. At 28 days, ventilator-associated pneumonia had developed in 62 patients (15%) in the amikacin group and in 95 patients (22%) in the placebo group (difference in restricted mean survival time to ventilator-associated pneumonia, 1.5 days; 95% confidence interval [CI], 0.6 to 2.5; P = 0.004). An infection-related ventilator-associated complication occurred in 74 patients (18%) in the amikacin group and in 111 patients (26%) in the placebo group (hazard ratio, 0.66; 95% CI, 0.50 to 0.89). Trial-related serious adverse effects were seen in 7 patients (1.7%) in the amikacin group and in 4 patients (0.9%) in the placebo group. Conclusions: Among patients who had undergone mechanical ventilation for at least 3 days, a subsequent 3-day course of inhaled amikacin reduced the burden of ventilator-associated pneumonia during 28 days of follow-up. (Funded by the French Ministry of Health; AMIKINHAL ClinicalTrials.gov number, NCT03149640; EUDRA Clinical Trials number, 2016-001054-17.).

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 28/11/2023
• Auteurs : Mohamed Said OughouEric BiotNicolas ArnaudAude Maugarny-CalèsPatrick LaufsPhilippe AndreyJasmine Burguet
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

---

Résumé : Morphogenesis is a process that spans several orders of magnitude in both time and space. Because it is generally impossible to follow developing organs all along growth, analyses typically rely on static data sampled at different developmental stages. We propose a model-based approach for the accurate dating of organs, allowing spatio-temporal reconstruction of organ morphogenesis over unlimited time windows, based on static data collected from different individuals. Although considered leaves in wild-type and mutant plants displayed contrasted final shapes and sizes, we revealed invariant, iterated developmental schemes, and identical critical time points, suggesting conserved morphogenetic modules. We provided evidence that modules determining local features may act independently of global leaf growth. In particular, we showed that serrations developing at different times and/or in different leaves grow in a remarkably synchronized way. In addition, graded differences in growth dynamics and final shapes of successive leaves suggest continuous variations in module expression. Altogether, we illustrated that our strategy is powerful to finely dissect multi-scale morphogenetic processes.

---

Source

---

• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 27/11/2023
• Auteurs : Lea ProchassonMakram Mghezzi-HabellahArmelle RoisinMartine PalmaJean-Philippe RobinSteve de BossoreilleDavid CluetMaleke MouehliDidier DecimoAlexandra DesramesThibault ChazeMariette MatondoHélène DutartreMarie-Isabelle ThoulouzeFabrice LejeunePierre JalinotStéphane RétyVincent Mocquet
• Organismes : Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Centre International de Recherche en Infectiologie Virologie Structurale - Structural Virology Plateforme de Protéomique / Proteomics platform Plateforme de Protéomique / Proteomics platform Centre International de Recherche en Infectiologie Virologie Structurale - Structural Virology Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule

---

Résumé : Abstract The hijacking of CRM1 export is an important step of the retroviral replication cycle. Here, we investigated the consequences of this hijacking for the host. During HTLV-1 infection, we identified the formation of a complex composed of Rex, CRM1 and the RNA helicase UPF1, leading to the nuclear retention of UPF1. We further showed how this leads to the inhibition of the nonsense mediated mRNA decay (NMD), known to have an antiviral function. Corroborating these results, we described a similar process with Rev, the functional homolog of Rex from HIV-1. Unexpectedly, we also found that, for HTLV-1, this process is coupled with the specific loading of UPF1 onto vRNA, independently of NMD. In this latter context, UPF1 positively regulates several steps of the viral replication cycle, from the nuclear export of vRNA to the production of mature viral particles.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 27/11/2023
• Auteurs : Odile FeysPierre CorvilainEtienne LabytMahdi MahmoudzadehLaura RoutierClaudine SculierNiall HolmesMatthew BrookesSerge GoldmanRudy RomainSergey MitryukovskiyAgustin Palacios-LaloyDenis SchwartzNacim BetrouniPhilippe DerambureFabrice WalloisVincent WensXavier de Tiège
• Organismes : Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis ULB Neuroscience Institute [Brussels] Mag4Health Euratechnologies Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 UPJV Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis School of Physics and Astronomy [Nottingham] School of Physics and Astronomy [Nottingham] ULB Neuroscience Institute [Brussels] Mag4Health Mag4Health Mag4Health Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 UPJV Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis ULB Neuroscience Institute [Brussels] Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis ULB Neuroscience Institute [Brussels]
• Publié dans Frontiers in Neuroscience le 24/10/2020

---

Résumé : Cryogenic magnetoencephalography (MEG) enhances the presurgical assessment of refractory focal epilepsy (RFE). Optically pumped magnetometers (OPMs) are cryogen-free sensors that enable on-scalp MEG recordings. Here, we investigate the application of tri-axial OPMs [ 87 Rb (Rb-OPM) and 4 He gas (He-OPM)] for the detection of interictal epileptiform discharges (IEDs). IEDs were recorded simultaneously with 4 tri-axial Rb- and 4 tri-axial He-OPMs in a child with RFE. IEDs were identified visually, isolated from magnetic background noise using independent component analysis (ICA) and were studied following their optimal magnetic field orientation thanks to virtual sensors. Most IEDs (>1,000) were detectable by both He- and Rb-OPM recordings. IEDs were isolated by ICA and the resulting magnetic field oriented mostly tangential to the scalp in Rb-OPMs and radial in He-OPMs. Likely due to differences in sensor locations, the IED amplitude was higher with Rb-OPMs. This case study shows comparable ability of Rb-OPMs and He-OPMs to detect IEDs and the substantial benefits of triaxial OPMs to detect IEDs from different sensor locations. Tri-axial OPMs allow to maximize spatial brain sampling for IEDs detection with a limited number of sensors.

---

Source

---

• Type de publi. :
• Date de publi. : 23/11/2023
• Auteurs : Pierre MorettoFrédéric GuittardPhilippe SouèresAnthony HerrelJosé de Jesus Castillo-ZamoraFranck RuffierThomas EngelsMatthieu VerdoucqChristophe GoupilMichaël GauthierBertrand TonduJulien SerresBruno Watier
• Organismes : Centre de Recherches sur la Cognition Animale - UMR5169 Centre de Biologie Intégrative NATURE INSPIRES CREATIVITY ENGINEERS LAB Équipe Mouvement des Systèmes Anthropomorphes Muséum national d'Histoire naturelle Institut des Sciences du Mouvement Etienne Jules Marey Institut des Sciences du Mouvement Etienne Jules Marey Centre National de la Recherche Scientifique Institut des Sciences du Mouvement Etienne Jules Marey Centre National de la Recherche Scientifique ENAC - Programme transverse Drones Laboratoire Interdisciplinaire des Energies de Demain Institut universitaire de France Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) Institut National des Sciences Appliquées Équipe Mouvement des Systèmes Anthropomorphes Aix Marseille Université Institut des Sciences du Mouvement Etienne Jules Marey Institut universitaire de France Équipe Mouvement des Systèmes Anthropomorphes

---

Résumé : L'axe "Mouvement, Déplacement, Biomécanique Biorobotique" du GDR Biomim 2088 est centré sur l’étude du déplacement et du mouvement, observables du comportement organisé depuis la perception et traduisant l’action voire l’intention. Les recherches s’intéressent ici à la compréhension de ces mécanismes qui permettent de migrer, de fuir et de se dissimuler ou de poursuivre et attraper, enfin de se déplacer seul ou en groupe d’individus parfaitement coordonnés. Ces habiletés ont assuré à qui les a acquises une capacité de survie et l’efficacité des modèles biologiques peut être démontrée à différentes échelles, dans différents contextes et environnements. Ils inspirent des modélisations et prototypes de capteurs, d’actionneurs, de systèmes poly-articulés et de robots « durs ou mous », qui, en plus de suppléer l’homme dans ses tâches, permettent d’avancer sur la compréhension du vivant en testant des hypothèses issues de la biologie, des neurosciences, de la physique et de la mécanique.

---

Fichiers liés : A - Intro MAH 2023.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 21/11/2023
• Auteurs : Candie JolyDelphine DesjardinsRaphaël PorcherHélène PéréThomas BruneauQian ZhangPaul BastardAurélie CobatLéa ResminiOlivia LenoirLaurent SavaleCamille LécurouxCéline VerstuyftAnne-Marie Roque-AfonsoDavid VeyerGabriel BaronMatthieu Resche-RigonPhilippe RavaudJean-Laurent CasanovaRoger Le GrandOlivier HerminePierre-Louis TharauxXavier Mariette
• Organismes : Infectious Diseases Models for Innovative Therapies Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Infectious Diseases Models for Innovative Therapies Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Université Paris Cité Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP] Université Paris Cité Institute of Botany [Beijing] Human genetics of infectious diseases : Mendelian predisposition Hôpital Necker - Enfants Malades [AP-HP] Rockefeller University [New York] Imagine - Institut des maladies génétiques (IHU) Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Centre de recherche en épidémiologie et santé des populations Service de Génétique Moléculaire Pharmacogénétique et Hormonologie [CHU Bicêtre] Physiopathologie et traitement des maladies du foie Hôpital Paul Brousse Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Hôtel-Dieu [Paris] Epidemiology and Clinical Statistics for Tumor, Respiratory, and Resuscitation | Epidémiologie Clinique, STatistique, pour la Recherche en Santé Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] Rockefeller University [New York] Howard Hughes Medical Institute Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Hôpital Necker - Enfants Malades [AP-HP] Paris-Centre de Recherche Cardiovasculaire Institut National de la Santé et de la Recherche Médicale UFR Médecine [Santé] - Université Paris Cité Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
• Publié dans Frontiers in Immunology le 25/10/2020

---

Résumé : Background The clinical outcome of COVID-19 pneumonia is highly variable. Few biological predictive factors have been identified. Genetic and immunological studies suggest that type 1 interferons (IFN) are essential to control SARS-CoV-2 infection. Objective To study the link between change in blood IFN-α2 level and plasma SARS-Cov2 viral load over time and subsequent death in patients with severe and critical COVID-19. Methods One hundred and forty patients from the CORIMUNO-19 cohort hospitalized with severe or critical COVID-19 pneumonia, all requiring oxygen or ventilation, were prospectively studied. Blood IFN-α2 was evaluated using the Single Molecule Array technology. Anti-IFN-α2 auto-Abs were determined with a reporter luciferase activity. Plasma SARS-Cov2 viral load was measured using droplet digital PCR targeting the Nucleocapsid gene of the SARS-CoV-2 positive-strand RNA genome. Results Although the percentage of plasmacytoid dendritic cells was low, the blood IFN-α2 level was higher in patients than in healthy controls and was correlated to SARS-CoV-2 plasma viral load at entry. Neutralizing anti-IFN-α2 auto-antibodies were detected in 5% of patients, associated with a lower baseline level of blood IFN-α2. A longitudinal analysis found that a more rapid decline of blood IFN-α2 was observed in fatal versus surviving patients: mortality HR=3.15 (95% CI 1.14–8.66) in rapid versus slow decliners. Likewise, a high level of plasma SARS-CoV-2 RNA was associated with death risk in patients with severe COVID-19. Conclusion These findings could suggest an interest in evaluating type 1 IFN treatment in patients with severe COVID-19 and type 1 IFN decline, eventually combined with anti-inflammatory drugs. Clinical trial registration https://clinicaltrials.gov , identifiers NCT04324073, NCT04331808, NCT04341584.

---

Fichiers liés : fimmu-14-1250214.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 21/11/2023
• Auteurs : Sybren de HoogThomas WalshSarah AhmedAna Alastruey-IzquierdoBarbara AlexanderMaiken Cavling ArendrupEsther BabadyFeng-Yan BaiJoan-Miquel Balada-LlasatAndrew BormanAnuradha ChowdharyAndrew ClarkRobert ColgroveOliver CornelyTanis DinglePhilippe DufresneJeff FullerJean-Pierre GangneuxConnie GibasHeather GlasgowYvonne GräserJacques GuillotAndreas H. GrollGerhard HaaseKimberly HansonAmanda HarringtonDavid HawksworthRandall T HaydenMartin HoeniglVit HubkaKristie JohnsonJulianne V KusRuoyu LiJacques MeisMichaela LacknerFanny LanternierSixto Leal Jr.Francesca LeeShawn LockhartPaul LuethyIsabella MartinKyung J Kwon-ChungWieland MeyerM. Hong NguyenLuis Ostrosky-ZeichnerElizabeth PalavecinoPreeti PancholiPeter PappasGary ProcopScott RedheadDaniel D RhoadsStefan RiedelBryan StevensKaede Ota SullivanPaschalis VergidisEmmanuel RoilidesAmir SeyedmousaviLili TaoVania VicenteRoxana VitaleQi-Ming WangNancy L WengenackLars WestbladeNathan WiederholdP. Lewis WhiteChristina M WojewodaSean X Zhang
• Organismes : École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques
• Publié dans Journal of Clinical Microbiology le 01/11/2020

---

Résumé : ABSTRACT The rapid pace of name changes of medically important fungi is creating challenges for clinical laboratories and clinicians involved in patient care. We describe two sources of name change which have different drivers, at the species versus the genus level. Some suggestions are made here to reduce the number of name changes. We urge taxonomists to provide diagnostic markers of taxonomic novelties. Given the instability of phylogenetic trees due to variable taxon sampling, we advocate to maintain genera at the largest possible size. Reporting of identified species in complexes or series should where possible comprise both the name of the overarching species and that of the molecular sibling, often cryptic species. Because the use of different names for the same species will be unavoidable for many years to come, an open access online database of the names of all medically important fungi, with proper nomenclatural designation and synonymy, is essential. We further recommend that while taxonomic discovery continues, the adaptation of new name changes by clinical laboratories and clinicians be reviewed routinely by a standing committee for validation and stability over time, with reference to an open access database, wherein reasons for changes are listed in a transparent way.

---

Source