Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Russell ChabanneThomas GeeraertsMarc BegardBaptiste BalançaFrancesca RapidoVincent DegosBenoit TavernierSerge MolliexLionel VellyFranck VerdonkAnne-Claire LukaszewiczPierre-François PerrigaultJean-François AlbucherChristophe CognardAdrien GuyotCharlotte FernandezAurélie MasgrauRicardo MorenoAnna FerrierSamir JaberJean-Etienne BazinBruno PereiraEmmanuel FutierKevin LagardeBernard CosserantThibaut CammasJulien PascalFlorian GrimaldiErwan LarocheCamille BoissyRomain GrobostPierre-Antoine PiocheJean-Baptiste JoffredoAudrey JohannyDenis SavraninJulien MassardierKatia LevrierAntoine BrandelyIsabelle LangladeDanielle SaurelNicolas RascolMélanie BailleauJulie FayonLaurent ValletElodie CaumonChristine RolhionDominique MorandJulien AmatBetty JeanEmmanuel ChabertAbderahim ZerrougJean GabrillarguesNathalie BourgoisXavier MoissetPierre ClavelouNicolas VitelloMaxime BeilvertEtienne AldigeSégolène MrozekFrancois DelortEdouard NaboulsiElsa TardifElodie ParryMaxime PommierMaud Prezman-PietriDavid RoussetClaire LarcherLouis DelamarreCharlotte MartinDiane OsinskiOlivier FourcadeJean Marc OlivotLionel CalviereNicolas RaposoAlain ViguierFabrice BonnevilleAnne-Christine JanuelPhilippe TallCaterina MichelozziJean DarcourtLionel BaptesteAnisoara GemanarCatherine MottoleseRoxane SilvePierre-François PerrigaultOcéane GarnierJérôme RidolfoMokhtar BouhaddjarJulien FendeleurJean Clement LauMélanie RatiéVincent CostalatFederico CagnazzoRomain PasqualottoFrédéric ClarenconGrégory TorkomianValentine BattistiElsa JozefowiczApolline KazemihruHilde HenonAurelie LafanechereLois HenryJulie BelletAlexandre GaudetFanny FoltzerLaurie ParmentierClément MagandMohamed AggourAnaele PregnyMarlène BonnefoiNicolas BruderCamille VaisseMichele BertrandyLaure DoukhanSophie CataldiInal ImaneValentine VerdierDidier SanchezJean-Claude DumontSouad FellousMarc GarnierOlivier LavabreDavid BernsteinViolaine BarangerElie ThomasChrysanthi PapagiannakiElisabeth LenormandJean-François PayenMathieu ZuberNicolas Molinari
• Organismes : Toulouse NeuroImaging Center Pôle Anesthésie Réanimation [CHU de Toulouse] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Evaluation des technologies de santé et des pratiques médicales - ULR 2694 Toulouse NeuroImaging Center Département Neurologie [CHU Toulouse] Service Neuroradiologie Diagnostique et Thérapeutique [CHU Toulouse] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Institut Desbrest d'Epidémiologie et de Santé Publique Médecine de précision par intégration de données et inférence causale
• Publié dans JAMA neurology le 24/10/2020

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Résumé : Importance General anesthesia and procedural sedation are common practice for mechanical thrombectomy in acute ischemic stroke. However, risks and benefits of each strategy are unclear. Objective To determine whether general anesthesia or procedural sedation for anterior circulation large-vessel occlusion acute ischemic stroke thrombectomy are associated with a difference in periprocedural complications and 3-month functional outcome. Design, Setting, and Participants This open-label, blinded end point randomized clinical trial was conducted between August 2017 and February 2020, with final follow-up in May 2020, at 10 centers in France. Adults with occlusion of the intracranial internal carotid artery and/or the proximal middle cerebral artery treated with thrombectomy were enrolled. Interventions Patients were assigned to receive general anesthesia with tracheal intubation (n = 135) or procedural sedation (n = 138). Main Outcomes and Measures The prespecified primary composite outcome was functional independence (a score of 0 to 2 on the modified Rankin Scale, which ranges from 0 [no neurologic disability] to 6 [death]) at 90 days and absence of major periprocedural complications (procedure-related serious adverse events, pneumonia, myocardial infarction, cardiogenic acute pulmonary edema, or malignant stroke) at 7 days. Results Among 273 patients evaluable for the primary outcome in the modified intention-to-treat population, 142 (52.0%) were women, and the mean (SD) age was 71.6 (13.8) years. The primary outcome occurred in 38 of 135 patients (28.2%) assigned to general anesthesia and in 50 of 138 patients (36.2%) assigned to procedural sedation (absolute difference, 8.1 percentage points; 95% CI, −2.3 to 19.1; P = .15). At 90 days, the rate of patients achieving functional independence was 33.3% (45 of 135) with general anesthesia and 39.1% (54 of 138) with procedural sedation (relative risk, 1.18; 95% CI, 0.86-1.61; P = .32). The rate of patients without major periprocedural complications at 7 days was 65.9% (89 of 135) with general anesthesia and 67.4% (93 of 138) with procedural sedation (relative risk, 1.02; 95% CI, 0.86-1.21; P = .80). Conclusions and Relevance In patients treated with mechanical thrombectomy for anterior circulation acute ischemic stroke, general anesthesia and procedural sedation were associated with similar rates of functional independence and major periprocedural complications. Trial Registration ClinicalTrials.gov Identifier: NCT03229148

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Fichiers liés : 2023 Chabanne et al., Outcomes After .pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Ingrid CostedoatMartin WallaertAurélie GaultierRobin VasseurClelia VanhaeckeManuelle ViguierCharles CordeletteAlexandre DenoyerMarie‐christine Ferrier Le BouëdecAdrien CoutuMarie LamiauxThi Ha Chau TranJean Philippe LacourValerie ElmalehFlorence TetartJulie GueudryMarie TauberFrancoise Giordano-LabadieMyriam CassagneAudrey NosbaumCoralie OuilhonMarie JachietRamin TadayoniFrederic DezoteuxDelphine Staumont-SalleJulien BouleauPierre LabaletteSerge DoanA. SoriaBruno MortemousqueJulien SeneschalSébastien Barbarot
• Organismes : Centre Hospitalier Universitaire de Bordeaux Physiopathologie des Adaptations Nutritionnelles Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Département de médecine générale [Nantes Université - UFR de Médecine et des Techniques Médicales] Physiopathologie des Adaptations Nutritionnelles Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Infections Cardiovasculaires Virales et inflammation en pathologie humaine (CardioVir) UMR-S 1320 Université de Clermont-Ferrand Service Ophtalmologie [CHU Clermont-Ferrand] Centre Hospitalier Régional Universitaire [CHU Lille] Université catholique de Lille Service de Dermatologie [Nice] Centre Hospitalier Universitaire de Nice Service de Dermatologie [Rouen] Service de pneumologie, allergologie, mucoviscidose pédiatrique [Rouen] Epidémiosurveillance de protozooses à transmission alimentaire et vectorielle Service d'ophtalmologie [Rouen] Institut Toulousain des Maladies Infectieuses et Inflammatoires Immunité de l’épiderme & allergie - Epidermal Immunity and Allergy [CIRI] Service Dermatologie [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre International de Recherche en Infectiologie Immunité de l’épiderme & allergie - Epidermal Immunity and Allergy [CIRI] Centre Hospitalier Lyon Sud [CHU - HCL] Assistance publique - Hôpitaux de Paris (AP-HP) Assistance publique - Hôpitaux de Paris (AP-HP) Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] CHU Tenon [AP-HP] CHU Tenon [AP-HP] Composantes innées de la réponse immunitaire et différenciation Centre Hospitalier Universitaire de Bordeaux Physiopathologie des Adaptations Nutritionnelles
• Publié dans Journal of the European Academy of Dermatology and Venereology le 27/10/2020

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Résumé : Abstract Background Although ocular adverse events are frequent in AD patients treated with dupilumab, their characterization remains limited due to a lack of prospective studies with a systematic ophthalmological examination. Objective To examine the incidence, characteristics and risk factors of dupilumab‐induced ocular adverse events. Methods A prospective, multicenter, and real‐life study in adult AD patients treated with dupilumab. Results At baseline, 27 out of 181 patients (14.9%) had conjunctivitis. At week 16 (W16), 25 out of 27 had improved their conjunctivitis and 2 remained stable and 34 out of 181 patients (18.7%) had dupilumab‐induced blepharoconjunctivitis: either de novo ( n = 32) or worsening of underlying blepharoconjunctivitis ( n = 2). Most events (27/34; 79.4%) were moderate. A multivariate analysis showed that head and neck AD (OR = 7.254; 95%CI [1.938–30.07]; p = 0.004), erythroderma (OR = 5.635; 95%CI [1.635–21.50]; p = 0.007) and the presence of dry eye syndrome at baseline (OR = 3.51; 95%CI [3.158–13.90]; p = 0.031) were independent factors associated with dupilumab‐induced blepharoconjunctivitis. Limitations Our follow‐up period was 16 weeks and some late‐onset time effects may still occur. Conclusion This study showed that most dupilumab‐induced blepharoconjunctivitis cases are de novo. AD severity and conjunctivitis at baseline were not found to be associated risk factors in this study.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Arianna CerutiNdongo DiaAdeleye Solomon BakareyJudah SsekitolekoSoa Fy AndriamandimbyPadra Malwengo-KasongoRasheeda H.A. AhmedRea Maja KobialkaJean Michel HeraudMoussa Moise DiagneMarie Henriette Dior DioneIdrissa DiengMartin FayeOusmane FayeJean Théophile RafisandratantsoaJean-Pierre RavaloheryClaudio RaharinandrasanaTsiry RandriambolamanantsoaNorosoa RazanajatovoIony RazanatovoJoelinotahina RabarisonPhilippe DussartLouis Kyei-TuffuorAbigail AgbanyoOlubusuyi Moses AdewumiAdeola FowotadeMuideen Kolawole RaifuPatient Okitale-TalundaGracia Kashitu-MujingaChristelle Mbelu-KabongoSteve Ahuka-MundekeAnguy Makaka-MutondoEnas AbdallaSanaa IdrisWisal ElmagzoubRahma AliEman O.M. NourRasha S.M. EbraheemHuda H.H. AhmedHamadelniel AbdallaMusab ElnegoumiIzdihar MukhtarMuatsim A.M. AdamNuha Y.I. MohamedShahinaz BedriHamdan Mustafa HamdanMagid KisekkaMonica MpumwiireSharley Melissa AloyoJoanita Nabwire WanderaAndrew AgabaRogers KamulegeyaHosea KiprotichDavid Patrick KateetePaul KadetzUwe TruyenKamal EltomAnavaj SakuntabhaiJulius Boniface OkuniSheila Makiala-MandandaVincent LacosteGeorge Olusegun AdemowoMichael FrimpongAmadou Alpha SallManfred WeidmannAhmed Abd El Wahed
• Organismes : Leipzig University / Universität Leipzig Institut Pasteur de Dakar University of Ibadan Makerere University [Kampala, Ouganda] Institut Pasteur de Madagascar Institut National de Recherche Biomédicale [Kinshasa] University of Kinshasa Federal Ministry of Health [Sudan] Leipzig University / Universität Leipzig Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur de Madagascar Institut Pasteur de Madagascar Institut Pasteur de Madagascar Institut Pasteur de Madagascar Institut Pasteur de Madagascar Institut Pasteur de Madagascar Institut Pasteur de Madagascar Institut Pasteur de Madagascar Kwame Nkrumah University of Science and Technology Kwame Nkrumah University of Science and Technology University of Ibadan University of Ibadan University of Ibadan Institut National de Recherche Biomédicale [Kinshasa] University of Kinshasa Institut National de Recherche Biomédicale [Kinshasa] University of Kinshasa Institut National de Recherche Biomédicale [Kinshasa] University of Kinshasa Institut National de Recherche Biomédicale [Kinshasa] University of Kinshasa Institut National de Recherche Biomédicale [Kinshasa] University of Kinshasa University of Khartoum University of Khartoum University of Khartoum Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Federal Ministry of Health [Sudan] Makerere University [Kampala, Ouganda] Makerere University [Kampala, Ouganda] Makerere University [Kampala, Ouganda] Makerere University [Kampala, Ouganda] Makerere University [Kampala, Ouganda] Makerere University [Kampala, Ouganda] Makerere University [Kampala, Ouganda] Makerere University [Kampala, Ouganda] Queen Margaret University College Leipzig University / Universität Leipzig University of Khartoum Génétique fonctionnelle des maladies infectieuses - Functional Genetics of Infectious Diseases Makerere University [Kampala, Ouganda] Institut National de Recherche Biomédicale [Kinshasa] University of Kinshasa Institut Pasteur de Madagascar University of Ibadan Kwame Nkrumah University of Science and Technology Institut Pasteur de Dakar Medizinische Hochschule Brandenburg Theodor Fontane / Brandenburg Medical School Theodor-Fontane Leipzig University / Universität Leipzig
• Publié dans Journal of Clinical Virology le 01/11/2020

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Résumé : Background The COVID-19 pandemic led to severe health systems collapse, as well as logistics and supply delivery shortages across sectors. Delivery of PCR related healthcare supplies continue to be hindered. There is the need for a rapid and accessible SARS-CoV-2 molecular detection method in low resource settings. Objectives To validate a novel isothermal amplification method for rapid detection of SARS-CoV-2 across seven sub-Sharan African countries. Study design In this multi-country phase 2 diagnostic study, 3,231 clinical samples in seven African sites were tested with two reverse transcription Recombinase-Aided Amplification (RT-RAA) assays (based on SARS-CoV-2 Nucleocapsid (N) gene and RNA-dependent RNA polymerase (RdRP) gene). The test was performed in a mobile suitcase laboratory within 15 min. All results were compared to a real-time RT-PCR assay. Extraction kits based on silica gel or magnetic beads were applied. Results Four sites demonstrated good to excellent agreement, while three sites showed fair to moderate results. The RdRP gene assay exhibited an overall PPV of 0.92 and a NPV of 0.88. The N gene assay exhibited an overall PPV of 0.93 and a NPV 0.88. The sensitivity of both RT-RAA assays varied depending on the sample Ct values. When comparing sensitivity between sites, values differed considerably. For high viral load samples, the RT-RAA assay sensitivity ranges were between 60.5 and 100% (RdRP assay) and 25 and 98.6 (N assay). Conclusion Overall, the RdRP based RT-RAA test showed the best assay accuracy. This study highlights the challenges of implementing rapid molecular assays in field conditions. Factors that are important for successful deployment across countries include the implementation of standardized operation procedures, in-person continuous training for staff, and enhanced quality control measures.

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Fichiers liés : 1-s2.0-S1386653223000446-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Christian P MoritzYannick TholancePierre-Baptiste VallayerLe-Duy DoSergio Muñiz-CastrilloVéronique RogemondKarine FerraudCoralie La MarcaJérôme HonnoratMartin KillianStéphane PaulJean-Philippe CamdessanchéJean-Christophe G Antoine
• Organismes : Service de Neurologie [CHU de Saint-Étienne] Synaptopathies et Autoanticorps [Lyon] Synaptopathies et Autoanticorps [Lyon] Service de Neurologie [CHU de Saint-Étienne] Synaptopathies et Autoanticorps [Lyon] Synaptopathies et Autoanticorps [Lyon] Synaptopathies et Autoanticorps [Lyon] Service de Neurologie [CHU de Saint-Étienne] Synaptopathies et Autoanticorps [Lyon] Synaptopathies et Autoanticorps [Lyon] Synaptopathies et Autoanticorps [Lyon] Physiopathologie et biothérapies des infections muqueuses [CIRI] Service de Médecine interne [CHU Saint-Etienne] Centre International de Recherche en Infectiologie Université Jean Monnet - Saint-Étienne Physiopathologie et biothérapies des infections muqueuses [CIRI] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne] Service de Neurologie [CHU de Saint-Étienne] Service de Neurologie [CHU de Saint-Étienne] Synaptopathies et Autoanticorps [Lyon]
• Publié dans Neurology Neuroimmunology & Neuroinflammation le 28/10/2020

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Résumé :

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Fichiers liés : NXI-2023-000009.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Benoît LevastMathieu FontaineStéphane NanceyPierre DéchelotteJoel DorePhilippe Lehert
• Organismes : MaaT Pharma [Lyon] Questel Consulting, Grenoble Centre Hospitalier Lyon Sud [CHU - HCL] Centre International de Recherche en Infectiologie CHU Rouen Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau MICrobiologie de l'ALImentation au Service de la Santé MetaGenoPolis University of Melbourne Université Catholique de Louvain = Catholic University of Louvain
• Publié dans Clinical and translational gastroenterology le 29/10/2020

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Résumé : Introduction: Patients with ulcerative colitis (UC) have a less diverse microbiome than healthy subjects. Multiple studies have evaluated fecal microbiota transfer (FMT) in these patients using different methods of product preparation, doses, and routes of administration. A systematic review and meta-analysis was performed to compare the efficacy of single-donor (SDN) and multidonor (MDN) strategies for product preparation.Methods: Systematic searches were performed in Web of Science, Scopus, PubMed, and Orbit Intelligence for studies comparing FMT products manufactured using SDN or MDN strategies to placebo in patients with UC. Fourteen controlled studies were selected for meta-analysis (10 randomized and 4 nonrandomized). The treatment response was assessed by using fixed- and random-effects models, and the significance of the indirect difference between the interventions was assessed using a network approach.Results: Considering all 14 studies, MDN and SDN were superior to placebo in terms of treatment response (risk ratios [RRs]: 4.41 and 1.57, respectively [P ≤ 0.001 for both]), and MDN was superior to SDN (RR: 2.81, P = 0.005). Meta-analysis of the 10 studies with high quality of evidence showed that MDN was superior to SDN in terms of treatment response (RR: 2.31, P = 0.042). Results were identical for both models.Discussion: There was a significant clinical benefit (remission) for patients with UC who received FMT with products manufactured by MDN strategies. Reduction of donor effect may lead to a gain in microbial diversity that could improve response to treatment. These results may have implications in the treatment approach of other diseases amenable to microbiome manipulation.

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Valentin MaisonsJean-Michel HalimiGregoire FauchierJean-Baptiste de FréminvilleNicolas GoinJuliette GueguenPhilippe GataultBenedicte SautenetDenis AngoulvantJulien HerbertArnaud BissonPierre-Henri DucluzeauLaurent Fauchier
• Organismes : Service de néphrologie et immunologie clinique [CHRU Tours] Transplantation, Immunologie, Inflammation [Tours] Service de néphrologie et immunologie clinique [CHRU Tours] Investigation Network Initiative - Cardiovascular and Rénal Clinical Trialist Centre Hospitalier Régional Universitaire de Tours Service d'Endocrinologie (CHRU Tours) Service de néphrologie et immunologie clinique [CHRU Tours] Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Régional Universitaire de Tours Service de néphrologie et immunologie clinique [CHRU Tours] Service de néphrologie et immunologie clinique [CHRU Tours] Centre Hospitalier Régional Universitaire de Tours Service de néphrologie et immunologie clinique [CHRU Tours] Centre Hospitalier Régional Universitaire de Tours Transplantation, Immunologie, Inflammation [Tours] Service de néphrologie et immunologie clinique [CHRU Tours] methodS in Patients-centered outcomes and HEalth ResEarch Investigation Network Initiative - Cardiovascular and Rénal Clinical Trialist Transplantation, Immunologie, Inflammation [Tours] Centre Hospitalier Régional Universitaire de Tours CHU Trousseau [Tours] Éducation Éthique Santé CHU Trousseau [Tours] Service d'Endocrinologie (CHRU Tours) Centre Hospitalier Régional Universitaire de Tours CHU Trousseau [Tours]
• Publié dans Diabetes & Metabolism le 31/10/2020

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• Type de publi. : Rapport
• Date de publi. : 01/05/2023
• Auteurs : Monique L'HostisPierre AutefPhilippe BernyMarc DelanoeJean-Claude DesfontisLionel GrisotPierre LebaillyCarine ParaudThierry PlouvierBruno PolackGilles MeyerCatherine BellocStéphane BertagnoliAlain BoissyHenri-Jean BoulouisMaria-Eleni FilippitziDavid FretinEmmanuelle Gilot-FromontEtienne GiraudViviane HenauxElsa JourdainSophie Le Bouquin Le NeveuSophie Le PoderElodie Monchatre-LeroyFrançois MeurensVirginie MichelPierre MormedeHervé MorvanAriane PayneMichel PepinCarole PerozClaire PonsartClaude SaegermanGaëlle SimonJean-Pierre VaillancourtCéline RenouardSophie BarreteauHicham Aït LbachaBenoit CourtyFlorence EtoreEric FresnayThierry GodardCatherine Gourlay-FranceJean-Christophe Faucon
• Organismes : École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique CAP VETO VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement Interactions Cellules Environnement - UR MSA Midi-Pyrénées Nord École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique Nutrition PhysioPathologie et Pharmacologie Groupement Technique Vétérinaire Université de Caen Normandie Laboratoire de Ploufragan-Plouzané-Niort [ANSES] Pathologies et bien être des ruminants École nationale vétérinaire d'Alfort Interactions hôtes-agents pathogènes [Toulouse] Biologie, Epidémiologie et analyse de risque en Santé Animale Interactions hôtes-agents pathogènes [Toulouse] Unité Mixte de Recherche sur les Herbivores - UMR 1213 Biologie moléculaire et immunologie parasitaires et fongiques Aristotle University of Thessaloniki Sciensano [Bruxelles] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement Innovations Thérapeutiques et Résistances Unité Epidémiologie et Appui à la Surveillance Unité Mixte de Recherche d'Épidémiologie des maladies Animales et zoonotiques Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Laboratoire de Ploufragan-Plouzané-Niort [ANSES] Laboratoire de la rage et de la faune sauvage de Nancy Biologie, Epidémiologie et analyse de risque en Santé Animale University of Saskatchewan [Saskatoon, Canada] Direction de la Stratégie et des Programmes INRAE Transfert LABOCEA Laboratoire [Plouzané, France] Office national de la chasse et de la faune sauvage VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement Centre Hospitalier Universitaire Vétérinaire d'Oniris [Nantes] Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Laboratoire de Ploufragan-Plouzané-Niort [ANSES] Université de Montréal Agence nationale du médicament vétérinaire Agence nationale du médicament vétérinaire Agence nationale du médicament vétérinaire Agence nationale du médicament vétérinaire Direction de l'Evaluation des Risques Agence nationale du médicament vétérinaire Agence nationale du médicament vétérinaire Laboratoire de Fougères - ANSES Agence nationale du médicament vétérinaire

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Résumé : L’émergence ou la réémergence de maladies vectorielles dont les agents pathogènes sont transmis par des insectes ou des tiques, l’augmentation de la prévalence de la gale psoroptique chez les ruminants, conduisent les vétérinaires à prescrire entre autres des traitements antiparasitaires externes (APE) sous forme de bains, douches, pulvérisations (BDP). Ces antiparasitaires sont des organophosphorés (OP), des pyréthrinoïdes ou encore un inhibiteur de la croissance larvaire. Ces traitements occasionnent une exposition des travailleurs aux émulsions antiparasitaires avec des risques potentiels pour l’utilisateur (pulvérisations et inhalation, bains/douches et éclaboussures…) et pour l’environnement (ruissellements des émulsions lors de pulvérisation, douche, épandage des reliquats de baignoire…). De plus, des défauts d’efficacité observés vis-à-vis de certaines myiases (Wohlfahrtia magnifica) conduisent à des pratiques éloignées des recommandations de prescription (surconcentrations, mélanges de différentes molécules, applications locales…). Les recommandations peuprécises des résumés des caractéristiques du produit (RCP) induisent un questionnement de la part des utilisateurs en termes de prévention de la santé des professionnels, d’impact environnemental notamment lié à l’élimination des effluents des élevages. Il en découle une nécessité de préciser davantage les pratiques d’utilisation de ces médicaments vétérinaires.

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Fichiers liés : SABA2018SA0269Ra.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Florian ChateletFrançois Régis FerrandSarah AtallahJuliette ThariatFrançois MouawadNicolas FakhryOlivier MalardCaroline EvenErwan de MonèsEmmanuelle Uro-CosteNazim BenzerdjebStéphane HansSylvie TestelinOlivier MauvaisDiane EvrardVianney BastitSébastien SalasFlorent EspitalierMarion ClasseLaurence DigueMélanie DoréStéphanie WongCharles DupinFrance NguyenJérémie BettoniAriane LapierreEmilien ColinPierre PhilouzeS. VergezBertrand BaujatPhilippe HermanBenjamin VerillaudJean-Marc ConstansAlexandre CoutteBernard Devauchelle
• Organismes : Service d'ORL et de Chirurgie cervico-faciale - Hôpital Foch CHU Tenon [AP-HP] Laboratoire de physique corpusculaire de Caen Faculté de Médecine Henri Warembourg - Université de Lille Laboratoire Parole et Langage Hôpital de la Conception [CHU - APHM] Regenerative Medicine and Skeleton Centre Hospitalier Universitaire de Toulouse Hospices Civils de Lyon UFR Sciences de la santé Simone Veil Chirurgie maxillofaciale et Stomatologie [CHU Amiens] CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors Centre Hospitalier Régional Universitaire de Besançon Méthodes computationnelles pour la prise en charge thérapeutique en oncologie : Optimisation des stratégies par modélisation mécaniste et statistique Hôpital Pellegrin CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors CHU Amiens-Picardie CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors CHU Amiens-Picardie CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 Chirurgie maxillofaciale et Stomatologie [CHU Amiens] Réseau d’Expertise Français sur les Cancers ORL Rares - French Network of Rare Head and Neck Tumors
• Publié dans European Journal of Cancer le 22/10/2020

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Résumé : Background: Acinic cell carcinomas (AciCCs) are malignant tumours of the salivary glands. The aim of this work was to analyse data from the national REFCOR multicenter cohort (i) to investigate the prognostic factors influencing survival outcomes in AciCC, (ii) to assess the impact on survival of postoperative radiotherapy (RT) in patients treated for AciCC without high-grade transformation and (iii) to explore the prognostic impact of prophylactic neck dissection (ND) in patients treated for AciCC of the major salivary glands. Patients and methods: Data from all the patients treated for salivary AciCC between 2009 and 2020 were extracted from the REFCOR database. Survival outcomes and prognostic factors influencing Disease-Free Survival (DFS) and Overall Survival (OS) were investigated using univariate and multivariate analyses. Propensity score matching was used to assess the impact of postoperative RT and prophylactic ND on DFS. Results: A total of 187 patients were included. After a median follow-up of 53 months, their 5-year OS and DFS rates were 92.8% and 76.2%, respectively. In multivariate analysis, male sex, older age, higher T and N status, and high grade were independently associated with a worse DFS. In the subpopulation analysed after propensity score matching, patients with cN0 AciCC without high-grade transformation who were treated by surgery and RT did not have an improved DFS compared to patients who were treated by surgery alone (hazard ratio (HR) = 0.87, p = 0.8). Factors associated with nodal invasion were T3-T4 status and intermediate/high histological grade. After propensity score matching, prophylactic ND was associated with a trend toward a better DFS (HR = 0.46, p = 0.16). Conclusions: These results suggest that (i) long-term follow-up (>5 years) should be considered in patients with AciCC, (ii) treatment by surgery alone could be an option in selected cN0 patients with AciCC without high-grade transformation and (iii) prophylactic ND may be considered preferentially in patients with T3-T4 status and/or intermediate/high histological grade.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Hiddo HeerspinkJai RadhakrishnanCharles AlpersJonathan BarrattStewart BielerUlysses DivaJula InrigRadko KomersAlex MercerIrene NoronhaMichelle RheaultWilliam RoteBrad RovinHoward TrachtmanHernán TrimarchiMuh Geot WongVlado PerkovicEric AlarmartineJonathan BarrattDong Wan ChaeLucia del VecchioJurgen FloegeShang-Jyh HwangBojan JelakovicBart MaesRobert MaleckiMarius MiglinasFernando Eduardo Barbosa NolascoManual PragaKannaiyan RabindranathMai RosenbergBrad RovinSydney Chi Wai TangVladmir TesarMuh Geot WongBhadran BoseMuralikrishna GangadharanStephen McdonaldChen PehSadia JahanChii YeapPhilip ClaytonGeorgina IrishNikhil ThyagarajanPeter HollettRathika KrishnasamyRobert CarrollShilpanjali JesudasonSusan CrailToby CoatesJane WaughEuan NobleKumaradevan MahadevanVictoria CampbellTania SalehiWai LimNeil BoudvilleAron ChakeraDoris ChanAnoushka KrishnanYusuf EqbalAlastair GilliesEswari VilayurThida Maung Maung MyintNicholas GrayJane WaughEuan NobleMelissa CheethamYusuf EqbalPeter HollettRathika KrishnasamyKumaradevan MahadevanVictoria CampbellCarol PollockBruce CooperAmanda MatherSarah RoxburghYvonne ShenStefanie StangenbergAmanda SiriwardanaEmma O'LoneSusan WanBrendon NeuenJeffrey Tsun Kit HaDana KimLauren HeathArunima JainElaine PhuaYan LiMartin GallagherMeg JardineAngus RitchieMona RazavianCeline FooteRoger WyndhamShaundeep SenZoltan EndreJonathan ErlichMangalee FernandoKenneth YongGrant LuxtonSradha KotwalSimon RogerVidu WijeratneDavid PackhamIan FraserBert VandewieleMargo LauteWim LemahieuSofie JamarSara OmbeletGert MeeusMarc DecupereOlivier SchockaertPeter DoubelLiesbeth ViaeneLuc RadermacherCatherine MassetMartial MoonenEric FirreMartina MilicevicXavier WarlingAn VanackerThomas MalfaitIvan DurlenIvica HorvaticAna SavukLana GellineoSandra KaranovicZivka DikaDjuro PlavljanicIvana MikacicDubravka Trajbar KentricDunja BarisicMarija StankovicKarolina Majstorovic BaracIvan KruljacDrasko PavlovicMartin DrinkovicIngrid PrkacinJerko BarbicZvonimir SitasDunja VujcicIvan RychlikAnna BenesovaKlara DrinovskaKarolina KratkaDita MaixnerovaMadis IlmojaKristin UntKadri LilienthalAsta AuerbachLiisi LeisJulia PielAnnika AdobergKulli KolvaldKristi VeermaeKadri TellingElviira SeppetJana UhlinovaPhilippe ZaouiPierre-Louis CarronIngrid MassonMiriana DinicDamien ThibaudinChristian BroyetNicolas MaillardHesham MoheyChristophe MariatGuillaume ClaisseEric AlamartineBertrand DussolStephane BurteyNoemie Chiche-JourdeJean-Emmanuel SerreGuillaume JeantetLeila ChenineAnne BlanchardStephane RoueffEric ThervetDavid FouassierAlexandre BuffetMarine LivrozetRoxane GaissetAlexandre KarrasAnne-Elisabeth HengCyril GarrousteCarole PhilipponnetClementine NicoloAlba AtenzaCamille LanaretClarisse GrezeValentin MayetClement DumondYahsou DelmasChristian CombeClaire RigothierLaure BurguetAurore LabatSimon MuchaValérie de PrécigoutThomas WeinreichHelmut ReichelDiliana DraganovaLothar WolfBernd HohensteinSven HeinrichsSimone KulkaSebahat SatLea WeilandThilo KruegerGunter WolfChristiane KettnerMandy SchlosserJohann Konstantin HerfurthAnnegret KochMartin BuschStephan Christian WerthMartin NitschkeFigen CakirogluFranziska SarnowLisa SchulzStefan WeinerNikolaus WirtzEric KoesterMarcus MoellerEleni StamellouSilja SandenHans Schmidt-GuertlerWanja BernhardtMargret PateckiGeorg SchlieperKevin SchulteAnnette GirardetUlrich KunzendorfLorraine Pui Yuen KwanMaggie Ming Yee MokGary Chi Wang ChanMingyao MaDavina Ngoi Wah LieAnthony Ting Pong ChanCheuk Chun SzetoKit Chung Jack NgSiu Fai CheungTak Tai Andrew YueKa Shun Samuel FungHon TangKa Fai YimWai Ping LawYick Hei WongChi Kwan Darwin LamSze Ho Sunny WongCarmelita MarcantoniRoberta AliottaFrancesca DeodatoGemma PatellaNicolino ComiCaterina VitaNazareno CarulloDavide BolignanoMichela MusolinoMatias TrilliniNorberto PericoGiuseppe RemuzziErica DainaLuigi BianconeLoredana CollaManuel BurdeseChiara CognoElena BoaglioIsabella AbbascianoCarlotta Federica ZizziPaolo RandonePietro NapodanoAnna RicchiutoMatthias CassiaSimone AccarinoMario CozzolinoRocco BaccaroStefano CostanziFederica Di MaioMaria ArenaFederica UrciuoloSara ViganoAndrea CavalliMonica LimardoMonica BordoliSerena PontiSelena LonghiAndrea SolazzoFrancesco GiaroniGabriele DonatiMassimo TorreggianiDavide CatucciMarco ColucciVittoria EspositoCiro EspositoLoreto GesualdoFlavia CapaccioEmma Diletta SteaCarmen SivoFrancesca AnneseFederica PapadiaPiergiorgio MessaMirco BelingheriPatrizia PasseriniSilvia MalvicaAlvita VickieneUrte ZakauskieneEgle AsakieneInga Arune BumblyteAsta StankuvieneLina SantockieneAshik HayatAllister WilliamsPeter SizelandEddie TanGerald WatersLai Wan ChanAndrew HendersonAngus TurnbullAndrew McnallyAnnie ReynoldsHelen PilmoreIan DittmerPaul ManleyElizabeth StallworthyTze GohDavid SempleMichael CollinsElizabeth CurryJafar AhmedThu NguyenAgata WiniarskaJustyna ZbrzezniakTomasz StomporMagdalena KrajewskaHanna Augustyniak-BartosikDorota ZielinskaAnna JanderMalgorzata StanczykMarcin TkaczykPrzemyslaw MiarkaDariusz AksamitPiotr JaskowskiWladyslaw SulowiczDominik CieniawskiJulita Gontarek-KacprzakElzbieta FelicjanczukNorbert KwellaBogna KwellaEwa SatoraJoão Carlos FernandesAna Marta GomesMarina ReisDaniela LopesCatarina AlmeidaHelena SáAna Carolina FigueiredoClara PardinhasEdgar AlmeidaMario RaimundoAna Cortesão CostaLuis Pedro Falcao GoncalvesSara FernandesSónia SilvaCatarina TeixeiraAdriana FernandesFernando NolascoPatricia AlvesMario GoisNuno FonsecaAna MessiasMaria MenezesFilipa CardosoHelena SousaJoana MarquesRui BarataJose Antonio LopesSofia JorgeJoana GameiroJose Nuno de Almeida Agapito FonsecaSara GoncalvesAna FarinhaPatricia Valerio SantosAna NatarioJose Carlos de Jesus BarretoCatarina AbrantesElsa Sofia Quadrado SoaresJoana de Sousa Soares FelgueirasLiliana CunhaLucia ParreiraTeresa FurtadoAlvaro VazKook-Hwan OhHajeong LeeSe Joong KimJong Cheol JeongYeong Hoon KimYunmi KimHyeong Cheon ParkHoon Young ChoiHyung Wook KimMoon Hyoung LeeSonguk YoonKyu-Beck LeeYoungyoul HyunTae-Hyun YooSeung Hyeok HanJung Tak ParkSunggyun KimYoung Rim SongJwa-Kyung KimHyung-Seok LeeNarae JooJungeun LeeHye Ryoun JangJunseok JeonWookyung ChungHyunhee LeeJae Hyun ChangKa Yeong ChunJi Yong JungHan RoAejin KimSang-Kyung JoJihyun YangMyung-Gyu KimSewon OhCaridad Martinez VillanuevaAna Vilar GimenoGustavo Andres Useche BonillaEsther TamaritAntonio Galan SerranoEduardo Verde MorenoJose Luño FernandezMaria Angeles Goicoechea DiezhandinoUrsula Verdalles GuzmanAna Perez de JoseAlberto Ortiz ArduanMaría Vanessa Pérez GómezCatalina Martín ClearyRaul Fernandez PradoElena GomaJose BallarinMontserrat Diaz EncarnacionIara da Silva SantosHelena Marco RusinolMonica FurlanoCarlos AriasClara BarriosEva Rodriguez GarciaAdriana Sierra OchoaBelen Vizcaino CastilloJonay Pantoja PerezMercedes Gonzalez MoyaMari SargsyanEmma Calatayud AristoyAna Avila BernabeuLeticia Perez LlunaTamara Malek MarinMaria Antonia Munar VilaIvon Maritza Bobadilla RicoNatalia Allende BurgosEduardo Gutierrez MartinezElena Gutierrez SolisAngel SevillanoEvangelina Merida HerreroJosep Miquel Blasco PelicanoLida Maria Rodas MarinLuis QuintanaMaria Antonieta Azancot RiveroNatalia Ramos TerradesClara Garcia CarroIrene Agraz PamplonaMercedes Salgueira LazoFrancisco de la Prada AlvarezFabiola Alonso GarciaWenceslao Adrian Aguilera MoralesSalia Virxinia Pol HeresAngel ForcenEduardo Parra MoncasiCristina Medrano VillarroyaAlejandro Soria VillenOlga Gracia GarciaMercedes Velo PlazaMaria Dolores Sánchez de la NietaMarta Calvo ArevaloAntolina MorenoSecundino Cigarran GuldrisManuel Pereira de VicenteMaria Antonia Munar VilaIvon Maritza Bobadilla RicoNatalia Allende BurgosBang-Gee HsuChih-Hsien WangCheng-Hsu ChenTung-Min YuMing-Ju WuShang-Feng TsaiChia-Tien HsuHsien-Fu ChiuKang-Ju ChouHua-Chang FangPo-Tsang LeeHsin-Yu ChenChien-Liang ChenChien-Wei HuangShih-Hsiang OuTzung-Yo HoChih-Yang HsuMing-Shan ChangYen-Ling ChiuYu-Sen PengKai-Hsiang ShuSzu-Yu PanShih-Ping HsuJu-Yeh YangMei-Fen PaiPo-Yu TsengHon-Yen WuWan-Chuan TsaiKuei-Ting TungHung-Yuan ChenHung-Chun ChenMei-Chuan KuoDaw-Yang HwangYi-Wen ChiuChi-Chih HungHung-Tien KuoJer-Chia TsaiKieran MccaffertySuzanne ForbesIndranil DasguptaMark ThomasAmar MahdiBamidele AjayiParamit ChowdhuryTheodoros KasimatisDimitrios MoutzourisCaroline DudreuilhRishi PruthiNick MansfieldGabriel DoctorSapna ShahSui KonPriscilla SmithPatrick HamiltonDurga KanigicherlaOmar Sherin Ibrahim RagyBassam AlchiOliver FlossmannFarid GhalliSarah LawmanSmeeta SinhaConstantina ChrysochouChukwuma ChukwuAine Maire de BhailisSaif Al ChalabiAmy HudsonArun GopuOlivia WickensJoshua StorrarMona WahbaNathan LordeMohammad RonySian GriffinFarah LatifMohammad AliLouise DasilvaJonathan Ayling-SmithEamon MahdiLisa WillcocksRachel JonesChee Kay CheungHaresh SelvaskandanDan PughMatthew SayerNeeraj DhaunFiona ChapmanPatrick MarkColin GeddesEmily McquarrieRajan PatelLaurence SolomonArvind PonnusamyAdam MorrisPedro OkohLauren FloydAjay DhaygudeJanson LeungChristopher GoldsmithBhavna PandyaDidem TezAshraf MikhailKaren BrownThomas BucknallMark LambieRoderick ComunaleDonald BrandonStacy MartinezAmanda HallAmy HendersonAaron FeardayNicole DouthitBrian SnowArnold SilvaCathylee SlyChristopher KellerRobert DavidsonJerry MengRobert HawsSiddhartha KattamanchiJavad MojarrabUnnikrishnan PillaiRichard LafayetteMichelle O'ShaughnessyFahameedah KamalKshama MehtaBruce BakerMario RuizPraveena JyothinagaramUsha PeriWilliam PaxtonJames TumlinKerri McgrealEllen MccarthyCassandra KimberArchana GautamKassem KhalilViet NguyenViet NguyenRaffi MinasianDariush ArfaaniaSam DaneshvariMichel ZakariArtashes PatrikyanRouzbeh AfsariChristine AyvazyanFaisal FakihMark LagattaFaisal FakihAlfred RodriguezJorge Enrique Monroy AvellaRamachandra PatakJigar KadakiaJai RadhakrishnanGerald AppelWooin AhnBradley NelsonAllyson MedinaSyeda AhmadYonatan PelegNisha ClementIan ChiuElizabeth HendrenAndrew BombackPietro CanettaBruce SpinowitzChaim CharytanNishita ParikhSheng KuoRitesh RaichoudhuryMirela DobreLavinia NegreaAparna PadiyarArksarapuk JittiratNishigandha PradhanRanjit DhelariaSaravanan BalamuthusamyMachaiah MadhriraThomas PowellHoward LiflandAsha BaileySarah Ashley Ford SightlerMeera Patel SutharHeather GreenSamir ParikhIsabelle AyoubSalem AlmaaniGabriel ContrerasAlessia FornoniYelena DrexlerAbdallah GearaBrittany SheridanGaia CoppockJonathan HoganCarlos GonzalezShamik BhadraPradip ChowdhuryKay KyawMay TanLathika RaakeshElder MendozaVeronica ViramontesAsghar ChaudhryJuan CarbonellRajdeep GadhVictor FernandezMohamad KassemRadu JacobKaren WilderBritt NewsomeKathryn KlammIrina SuyumovaLaura Ann KooiengaCatherine JankoDana RizkBruce JulianDawn CasterErika PerezGunjan GargNayan GowdaSuneel UdaniSreedhar MandayamBiruh WorkenehRoderick ComunaleDonald BrandonUnnikrishnan PillaiAli AssefiBarbara GrecoMichael GermainJusmin PatelSarah QuinnJames SullivanJeffrey GlazePhillip MadoniaKellyn McmahonHarold GilesSharon AdlerTiane Dai
• Organismes : University of Groningen [Groningen] University of New South Wales [Sydney] KI Editorial Board Columbia University Medical Center University of Leicester University of Minnesota Medical School The Ohio State University [Columbus] New York University Langone Medical Center University of New South Wales [Sydney] University of Leicester Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias Service Néphrologie, Hémodialyses [CHU Clermont-Ferrand]
• Publié dans The Lancet le 02/11/2020

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Résumé : Background: Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety. Methods: PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 years) with biopsy-proven IgA nephropathy and proteinuria of 1·0 g/day or higher despite maximised renin-angiotensin system inhibitor treatment for at least 12 weeks. Participants were randomly assigned in a 1:1 ratio to receive sparsentan 400 mg once daily or irbesartan 300 mg once daily, stratified by estimated glomerular filtration rate at screening (30 to <60 mL/min per 1·73 m2 and ≥60 mL/min per 1·73 m2) and urine protein excretion at screening (≤1·75 g/day and >1·75 g/day). The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. All endpoints were examined in all participants who received at least one dose of randomised treatment. The study is ongoing and is registered with ClinicalTrials.gov, NCT03762850. Findings: Between Dec 20, 2018, and May 26, 2021, 404 participants were randomly assigned to sparsentan (n=202) or irbesartan (n=202) and received treatment. At week 36, the geometric least squares mean percent change from baseline in urine protein-creatinine ratio was statistically significantly greater in the sparsentan group (-49·8%) than the irbesartan group (-15·1%), resulting in a between-group relative reduction of 41% (least squares mean ratio=0·59; 95% CI 0·51-0·69; p<0·0001). TEAEs with sparsentan were similar to irbesartan. There were no cases of severe oedema, heart failure, hepatotoxicity, or oedema-related discontinuations. Bodyweight changes from baseline were not different between the sparsentan and irbesartan groups. Interpretation: Once-daily treatment with sparsentan produced meaningful reduction in proteinuria compared with irbesartan in adults with IgA nephropathy. Safety of sparsentan was similar to irbesartan. Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Jean-Philippe ChampeauxPatrick Moretto-CapelleJulie RenoudLaurent PolizziStéphane FaureDaniel CastexMichel GianesinEric PanaderPhilippe PaquierWilliam VolondatThibaud SalbaingJonathan RiffaudRobinson PointPierre CafarelliMartine Sence
• Organismes : Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Hospices Civils de Lyon CEA/DAM [Arpajon] Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Laboratoire Collisions Agrégats Réactivité
• Publié dans Physical Chemistry Chemical Physics le 02/11/2020

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Résumé : In this work, ionization and fragmentation of the prebiotic molecule Hydantoin by electron impact was investigated in our new experimental set-up. Scanning of the incident electron energy make possible the determination of appearance thresholds of the parent molecule i.e. vertical ionization potential found in good agreement with previous data but also dissociation thresholds for the main fragmentation patterns. In parallel, thanks to quantum chemistry calculations, reaction schemes compatible with experimental results are given

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Fichiers liés : hydantoine-2023-hal.pdf

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