Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 30/03/2023
• Auteurs : Daniel R. van RossumJanik KarolyKate PattleAnthony WhitworthJason KirkDavid BerryPierre BastienTao-Chung ChingSimon CoudéJihye HwangWoojin KwonArchana SoamJia-Wei WangTetsuo HasegawaShih-Ping LaiKeping QiuDoris ArzoumanianTyler BourkeDo-Young ByunHuei-Ru Vivien ChenWen Ping ChenMike ChenZhiwei ChenJungyeon ChoMinho ChoiYoungwoo ChoiYunhee ChoiA. ChrysostomouEun Jung ChungY. Sophia DaiVictor DebattistaJames Di FrancescoP. DiepYasuo DoiHao-Yuan DuanYan DuanChakali EswaraiahLapo FanciulloJason FiegeLaura FisselErica FranzmannPer FribergRachel FriesenGary FullerRay FuruyaTim GledhillSarah GravesJane GreavesMatt GriffinQi-Lao 琦烙 Gu 顾Ilseung HanSaeko HayashiThiem HoangMartin HoudeCharles L H HullTsuyoshi InoueShu-Ichiro InutsukaKazunari IwasakiIl-Gyo JeongDoug JohnstoneVera KönyvesJi-Hyun KangMiju KangAkimasa KataokaKoji S KawabataFrancisca KemperJongsoo KimShinyoung KimGwanjeong KimKyoung Hee KimMi-Ryang KimKee-Tae KimHyosung KimFlorian KirchschlagerMasato KobayashiPatrick M KochTakayoshi KusuneJungmi KwonKevin LacailleChi-Yan LawC.-W. LeeHyeseung LeeYong-Hee LeeChin-Fei LeeJeong-Eun LeeSang-Sung LeeDalei LiDi LiGuangxing LiHua-Bai LiSheng-Jun 聖鈞 Lin 林Hong-Li LiuTie 铁 Liu 刘Sheng-Yuan LiuJunhao LiuS. LongmoreXing LuA.-Ran LyoSteve MairsMasafumi 雅文 Matsumura 松村Brenda MatthewsGerald Moriarty-SchievenTetsuya NagataSandhyarani PanigrahyHiroyuki NakanishiNguyen Bich NgocNagayoshi OhashiTakashi OnakaGeumsook ParkHarriet ParsonsNicolas PerettoFelix PriestleyTae-Soo PyoLei QianRamprasad RaoJonathan RawlingsMark RawlingsBrendan RetterJohn RicherAndrew RigbySarah SadavoyHiro SaitoGiorgio SaviniMasumichi SetaYoshito ShimajiriHiroko ShinnagaMehrnoosh TahaniMotohide TamuraYa-Wen TangXindi TangKohji TomisakaLe Ngoc TramYusuke TsukamotoSerena VitiHongchi WangJintai WuJinjin XieMeng-Zhe YangHsi-Wei YenHyunju YooJinghua YuanHyeong-Sik YunTetsuya ZenkoGuoyin ZhangYapeng ZhangChuan-Peng ZhangJianjun ZhouLei ZhuIlse de LoozePh. AndréC. Darren DowellD. EdenStewart EyresSam FalleValentin Le GouellecF PoidevinJean-François RobitailleSven van Loo
• Organismes : University of Central Lancashire [Preston]
• Publié dans The Astrophysical Journal le 22/10/2020

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Résumé : Abstract We present BISTRO Survey 850 μ m dust emission polarization observations of the L1495A-B10 region of the Taurus molecular cloud, taken at the James Clerk Maxwell Telescope (JCMT). We observe a roughly triangular network of dense filaments. We detect nine of the dense starless cores embedded within these filaments in polarization, finding that the plane-of-sky orientation of the core-scale magnetic field lies roughly perpendicular to the filaments in almost all cases. We also find that the large-scale magnetic field orientation measured by Planck is not correlated with any of the core or filament structures, except in the case of the lowest-density core. We propose a scenario for early prestellar evolution that is both an extension to, and consistent with, previous models, introducing an additional evolutionary transitional stage between field-dominated and matter-dominated evolution, observed here for the first time. In this scenario, the cloud collapses first to a sheet-like structure. Uniquely, we appear to be seeing this sheet almost face on. The sheet fragments into filaments, which in turn form cores. However, the material must reach a certain critical density before the evolution changes from being field dominated to being matter dominated. We measure the sheet surface density and the magnetic field strength at that transition for the first time and show consistency with an analytical prediction that had previously gone untested for over 50 yr.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 29/03/2023
• Auteurs : Anu MishraBin ZhouAndrea Rodriguez-MartinezHonor BixbyRosie SingletonRodrigo Carrillo-LarcoKate ShefferChristopher PaciorekJames BennettVictor LhosteMaria IurilliMariachiara Di CesareJames BenthamNowell PhelpsMarisa SophieaGretchen StevensGoodarz DanaeiMelanie CowanStefan SavinLeanne RileyEdward GreggWichai AekplakornNoor Ani AhmadJennifer BakerAdela Chirita-EmandiFarshad FarzadfarGünther FinkMirjam HeinenNayu IkedaAndre KengneYoung-Ho KhangTiina LaatikainenAvula LaxmaiahJun MaMichele Monroy-ValleMalay MridhaCristina PadezAndrew ReynoldsMaroje SorićGregor StarcJames WirthLeandra Abarca-GómezZiad AbdeenShynar AbdrakhmanovaSuhaila Abdul GhaffarHanan Abdul RahimZulfiya AbdurrahmonovaNiveen Abu-RmeilehJamila Abubakar GarbaBenjamin Acosta-CazaresIshag AdamMarzena AdamczykRobert AdamsSeth Adu-AfarwuahKaosar AfsanaShoaib AfzalValirie AgborImelda AgdeppaJavad Aghazadeh-AttariHassan AguenaouCarlos Aguilar-SalinasCharles AgyemangMohamad Hasnan AhmadAli AhmadiNaser AhmadiNastaran AhmadiImran AhmedSoheir AhmedWolfgang AhrensGulmira AitmurzaevaKamel AjlouniHazzaa Al-HazzaaBadreya Al-LahouRajaa Al-RaddadiHuda Al HouraniNawal Al QaoudMonira AlaroujFadia AlbuhairanShahla AldhukairMaryam AldwairjiSylvia AlexiusMohamed AliAbdullah AlkandariAla’a AlkerwiButhaina AlkhatibKristine AllinMar Alvarez-PedrerolEman AlyDeepak AmarapurkarPilar Amiano EtxezarretaJohn AmoahNorbert AmougouPhilippe AmouyelLars Bo AndersenSigmund AnderssenOdysseas AndroutsosLars ÄngquistRanjit Mohan AnjanaAlireza Ansari-MoghaddamElena AnufrievaHajer Aounallah-SkhiriJoana AraújoInger AriansenTahir ArisRaphael ArkuNimmathota ArlappaKrishna AryalNega AseffaThor AspelundFelix AssahBatyrbek AssembekovMaria Cecília F. 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ReganitValéria RegecováJane RennerJudit RepasyCézane ReuterLuis RevillaAbbas RezaianzadehYeunsook RhoLourdes Ribas-BarbaRobespierre RibeiroElio RiboliAdrian RichterFernando RigoAttilio RigottiNatascia RinaldoTobias Rinke de WitAna RitoRaphael Ritti-DiasJuan RiveraReina RoaLouise RobinsonCynthia RobitailleRomana RoccaldoDaniela RodriguesFernando Rodríguez-ArtalejoMaría del Cristo Rodriguez-PerezLaura Rodríguez-VillamizarAndrea RodríguezUlla RoggenbuckPeter RohloffFabian RohnerRosalba Rojas-MartinezNipa RojroongwasinkulDora RomagueraElisabetta RomeoRafaela RosarioAnnika RosengrenIan RouseVanessa RouzierJoel RoyMaira RuanoAdolfo RubinsteinFrank RühliJean-Bernard RuidavetsBlanca Sandra Ruiz-BetancourtMaria Ruiz-CastellEmma Ruiz MorenoIuliia RusakovaKenisha Russell JonssonPaola RussoPetra RustMarcin RutkowskiMarge SaamelCharumathi SabanayagamHamideh SabbaghiElena SacchiniHarshpal SachdevAlireza SadjadiAli Reza SafarpourSare SafiSaeid SafiriMohammad Hossien SaghiOlfa SaidiNader SakiSanja ŠalajBenoit SalanaveEduardo Salazar MartinezCalogero SalevaDiego SalmerónVeikko SalomaaJukka SalonenMassimo SalvettiMargarita SamoutianJose Sánchez-AbantoInés Sánchez RodríguezSusana SansLoreto Santa MarinaEthel SantacruzDiana SantosIna SantosLèlita SantosMaria Paula SantosOsvaldo SantosRute SantosTamara SantosJouko SaramiesLuis SardinhaNizal SarrafzadeganThirunavukkarasu SathishKai-Uwe SaumSavvas SavvaMathilde SavyNorie SawadaMariana SbarainiMarcia ScazufcaBeatriz SchaanAngelika Schaffrath RosarioHerman SchargrodskyAnja SchienkiewitzKarin SchindlerSabine SchipfCarsten SchmidtIda Maria SchmidtAndrea SchneiderPeter SchnohrBen SchöttkerSara SchrammStine SchrammHelmut SchröderConstance SchultszMatthias SchulzeAletta SchutteSylvain SebertMoslem SedaghattalabRusidah SelamatVedrana SemberAbhijit SenIdowu SenbanjoSadaf SepanlouGuillermo SequeraLuis Serra-MajemJennifer ServaisĽudmila ŠevčíkováSvetlana ShalnovaTeresa Shamah-LevySeyed Morteza ShamshirgaranCoimbatore Subramaniam ShanthiraniMaryam SharafkhahSanjib SharmaJonathan ShawAmaneh ShayanradAli Akbar ShayestehLela ShengeliaZumin ShiKenji ShibuyaHana Shimizu-FurusawaTal ShimonyRahman ShiriNamuna ShresthaKhairil Si-RamleeAlfonso SianiRosalynn SiantarAbla SibaiLabros SidossisNatalia SilitrariAntonio SilvaCaroline Ramos de Moura SilvaDiego Augusto Santos SilvaKelly SilvaXueling SimMary SimonJudith SimonsLeon SimonsAgneta SjöbergMichael SjöströmNatalia SkoblinaGry SkodjeTatyana SlazhnyovaJolanta Slowikowska-HilczerPrzemysław SlusarczykLiam SmeethHung-Kwan SoFernanda Cunha SoaresGrzegorz SobekEugène SobngwiMorten SodemannStefan SöderbergMoesijanti SoekatriAgustinus SoemantriReecha SofatVincenzo SolfrizziMohammad Hossein SomiEmily SonestedtYi SongSajid SoofiThorkild SørensenElin SørgjerdCharles Sossa JéromeVictoria Soto-RojasAïcha SoumaréAlfonso Sousa-PozaSlavica SovicBente Sparboe-NilsenKaren SparrenbergerPhoebe SpencerAngela SpinelliIgor SpiroskiJan StaessenHanspeter StammKaspar StaubBill StavreskiJostein Steene-JohannessenPeter StehleAryeh SteinGeorge StergiouJochanan StessmanRanko StevanovićJutta StieberDoris StöcklJakub StokwiszewskiEkaterina StoyanovaGareth StrattonKarien StronksMaria Wany StrufaldiLela SturuaRamón Suárez-MedinaMachi SukaChien-An SunLiang SunJohan SundströmYn-Tz SungJordi SunyerPaibul SuriyawongpaisalNabil William G. SweisBoyd SwinburnRody SyRené Charles SylvaMoyses SzkloLucjan SzponarLorraine TaboneE. Shyong TaiKonstantinos TambalisMari-Liis TammesooAbdonas TamosiunasEng Joo TanXun TangMaya TanrygulyyevaFrank TanserYong TaoMohammed Rasoul TarawnehJakob TarpCarolina Tarqui-MamaniRadka Taxová BraunerováAnne TaylorJulie TaylorFélicité TchibindatSaskia Te VeldeWilliam TebarGrethe TellTania TelloYih Chung ThamK. ThankappanHolger TheobaldXenophon TheodoridisNihal ThomasBarbara ThorandBetina ThuesenĽubica TicháErik TimmermansDwi TjandrariniAnne TjonnelandHanna TolonenJanne TolstrupMurat TopbasRoman Topór-MądryLiv Elin TorheimMaría José TormoMichael TornaritisMaties TorrentLaura Torres-ColladoStefania ToselliGiota TouloumiPierre TraissacThi Tuyet-Hanh TranMark TremblayAreti TriantafyllouDimitrios TrichopoulosAntonia TrichopoulouOanh TrinhAtul TrivediYu-Hsiang TsaoLechaba TshepoMaria TsiggaPanagiotis TsintavisShoichiro TsuganeJohn TuiteleAzaliia TuliakovaMarshall Tulloch-ReidFikru TulluTomi-Pekka TuomainenJaakko TuomilehtoMaria TurleyGilad TwigPer TyneliusEvangelia TzalaThemistoklis TzotzasChristophe TzourioPeter UedaEunice UgelFlora UkoliHanno UlmerBelgin UnalZhamyila UsupovaHannu UusitaloNalan UysalJustina VaitkeviciuteGonzalo ValdiviaSusana ValeDamaskini ValviRob van DamBert-Jan van den BornJohan van der HeydenYvonne van der SchouwKoen van HerckWendy van LippeveldeHoang van MinhNatasja van SchoorIrene van ValkengoedDirk VanderschuerenDiego VanuzzoAnette VarboGregorio Varela-MoreirasLuz Nayibe VargasPatricia Varona-PérezSenthil VasanDaniel VasquesTomas VegaToomas VeidebaumGustavo Velasquez-MelendezBiruta VelikaMaïté VerloigneGiovanni VeronesiW. VerschurenCesar VictoraGiovanni ViegiLucie VietFrøydis VikMonica VilarSalvador VillalpandoJesus VioqueJyrki VirtanenSophie Visvikis-SiestBharathi ViswanathanMihaela VladulescuTiina VlasoffDorja VocanecPeter VollenweiderHenry VölzkeAri VoutilainenMartine VrijheidTanja VrijkotteAlisha WadeThomas WaldhörJanette WaltonElvis WambiyaWan Mohamad Wan BebakarWan Nazaimoon Wan MohamudRildo de Souza Wanderley JúniorMing-Dong WangNingli WangQian WangXiangjun WangYa Xing WangYing-Wei WangS. Goya WannametheeNicholas WarehamAdelheid WeberKaren Webster-KerrNiels WedderkoppDaniel WeghuberWenbin WeiAneta WeresBo WernerLeo WestburyPeter WhincupKremlin WickramasingheKurt WidhalmIndah WidyaheningAndrzej WięcekPhilipp WildRainford WilksJohann WilleitPeter WilleitJulianne WilliamsTom WilsgaardRusek WojciechBogdan WojtyniakKathrin WolfRoy Wong-McclureAndrew WongEmily WongJyh Eiin WongTien Yin WongJean WooMark WoodwardFrederick WuHon-Yen WuJianfeng WuLi Juan WuShouling WuJustyna WyszyńskaHaiquan XuLiang XuNor Azwany YaacobUruwan YamborisutWeili YanLing YangXiaoguang YangYang YangNazan YardimTabara YasuharuMartha Yépez GarcíaPanayiotis YiallourosAgneta YngveMoein YoosefiAkihiro YoshiharaQi Sheng YouSan-Lin YouNovie Younger-ColemanYu-Ling YuYunjiang YuSafiah Md YusofAhmad Faudzi YusoffLuciana ZaccagniVassilis ZafiropulosAhmad ZainuddinSeyed Rasoul ZakaviFarhad ZamaniSabina ZambonAntonis ZampelasHana ZamrazilováMaria Elisa ZapataAbdul Hamid ZargarKo Ko ZawAyman ZayedTomasz ZdrojewskiMagdalena ŻegleńKristyna ZejglicovaTajana Zeljkovic VrkicYi ZengLuxia ZhangZhen-Yu ZhangDong ZhaoMing-Hui ZhaoWenhua ZhaoYanitsa ZhechevaShiqi ZhenWei ZhengYingfeng ZhengBekbolat ZholdinMaigeng ZhouDan ZhuMarie ZinsEmanuel ZittYanina ZocaloNada ZoghlamiJulio Zuñiga CisnerosMonika ZuziakZulfiqar BhuttaRobert BlackMajid Ezzati
• Organismes : Éco-Anthropologie Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Institut National de la Santé et de la Recherche Médicale Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences) Montpellier Interdisciplinary center on Sustainable Agri-food systems (Social and nutritional sciences)
• Publié dans Nature le 29/10/2020

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Résumé : Abstract Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being 1–6 . Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m –2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified.

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Fichiers liés : NCD-RisC Growth in rural and urban children (revision).pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 27/03/2023
• Auteurs : Jean-Philippe EglingerPierre Journoud
• Organismes : Institut National des Langues et Civilisations Orientales Centre de Recherches Interdisciplinaires en Sciences humaines et Sociales de Montpellier

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Résumé : aught between the consequences of the stalemate of the Russian invasion of Ukraine and the aggravation of Sino-American tensions, particularly around Taiwan and in the South China Sea, Vietnam must gradually readjust its foreign and defence policy to maintain balanced relations with its main partners. This might allow for a window of opportunity for France and the EU. In 2022, Vietnam successfully and fairly comprehensively managed covid-19 prevention and started to promote socio-economic development. Economic recovery was strong, as Vietnam may have benefited from a relocation of production from China. However, the coming year 2023 is forecasted to be more difficult for Vietnam as the global economy declines and as the Vietnamese economy remains dependent on export markets such as China, its main partner, but also the USA, and the EU. This situation could offer a good opportunity to implement a consistent economic reorientation.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 27/03/2023
• Auteurs : Christophe MaurelZaigham ShahzadLouai RishmawiOlivier RodriguesVirginia ProttoFabrice BaugetColette Tournaire-RouxYann BoursiacVéronique SantoniPhilippe NacryErwin GrillOlivier Loudet
• Organismes : Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Institut des Sciences des Plantes de Montpellier Technische Universität Munchen = Technical University Munich = Université Technique de Munich Institut Jean-Pierre Bourgin - Sciences du végétal

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• Type de publi. : Communication dans un congrès
• Date de publi. : 25/03/2023
• Auteurs : J. ChabertRomain IcickJulien CabéM.-C. PatozXavier MoissetOphélia GodinS. GardJ. LoftusV. AubinRaoul BelzeauxCaroline DubertretY. LestratN. MazerAlix de PrémorelP. RouxMircea PolosanThomas SchwitzerBruno AouizerateB. IsabelleB EtainRomain MoirandÉmilie OliéEmmanuel HaffenMarion LeboyerPhilippe CourtetPierre-Michel LlorcaGeorges BrousseLudovic Samalin
• Organismes : Institut Pascal CHU Clermont-Ferrand Optimisation thérapeutique en Neuropsychopharmacologie Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal Institut Pascal CHU Clermont-Ferrand Institut Pascal CHU Clermont-Ferrand CHU Clermont-Ferrand Institut Pascal Fondation FondaMental [Créteil] Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Centre Hospitalier Princesse Grace Centre Hospitalier Princesse Grace Assistance Publique - Hôpitaux de Marseille Institut de Neurosciences de la Timone Institut de psychiatrie et neurosciences de Paris Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Hôpital Louis Mourier - AP-HP [Colombes] Centre de recherche en épidémiologie et santé des populations [GIN] Grenoble Institut des Neurosciences Centre Hospitalier Universitaire [CHU Grenoble] Imagerie Adaptative Diagnostique et Interventionnelle Centre Hospitalier Régional Universitaire de Nancy Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal Optimisation thérapeutique en Neuropsychopharmacologie Hôpital Lariboisière-Fernand-Widal [APHP] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Centre Hospitalier le Vinatier [Bron] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Centre d'Investigation Clinique de Besançon Centre Hospitalier Régional Universitaire de Besançon Hôpital Henri Mondor Institut Mondor de Recherche Biomédicale Centre Hospitalier Régional Universitaire [Montpellier] CHU Clermont-Ferrand Institut Pascal Institut Pascal CHU Clermont-Ferrand Institut Pascal CHU Clermont-Ferrand

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Résumé : Introduction : Bipolar Disorder (BD) is a common psychiatric disease. It has been demonstrated a long time ago that bipolar patients are more painful than the healthy subjects. Substance use disorder is a frequent comorbidity in BD, but also in painful patients. The aim of our study was to analyze if bipolar patients with a painful expression have more substance use disorder than bipolar patients without pain. Objectives : The aim of our study was to analyze if bipolar patients with a painful expression have more substance use disorder than bipolar patients without pain. Methods : We included all bipolar patients from the FACE-BD cohort which is a prospective cohort of French outpatients with BD enrolled at the 12 advanced Centers of Expertise in Bipolar Disorder (CEBD). Pain has been evaluated by the “pain item” of the EQ-5D scale and we divided subjects in four categories: “no pain”, “slight pain”, “moderate pain”, “severe or extreme pain”. A multivariate analysis was performed to identify differences between each pain’s groups according to the kind of substance use disorder, psychiatric comorbidities and clinicals data. Results : The cohort enrolled 1897 bipolar patients, 970 had no pain (51.1%), 507 had slight pain (26.7%), 298 had moderate pain (15.7%) and 122 had severe or extreme pain (6.4%). We found significant differences according to age, comorbidities and clinicals data with older, more anxious, and more severe patients more represented in the more painful groups. Painful bipolar patients had also more frequently lifetime substance use disorders (alcohol, opioid, sedative, marijuana) and we were able to characterize different profiles in bipolar patients. Conclusions : Bipolar patients with a painful expression had more risks to have a lifetime substance use disorder, an anxiety disorder, and a higher score on MADRS. Interestingly, subjects seemed to prefer substances with anxiolytic or antalgic effects during the acute intoxication as alcohol, marijuana, opioid and sedatives.

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Fichiers liés : substance-use-disorders-in-bipolar-patients-with-a-painful-expression.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 23/03/2023
• Auteurs : Daniel T CassidyJean-Pierre LandesmanMerwan MokhtariPhilippe Pagnod-RossiauxMarc FouchierChristian Monachon
• Organismes : McMaster University [Hamilton, Ontario] Institut des Fonctions Optiques pour les Technologies de l'informatiON 3SP Technologies 3SP Technologies Attolight AG Attolight AG
• Publié dans Optics le 18/02/2021

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Résumé : Measurements of the cathodoluminescence (CL) and the degree of polarization (DOP) of (CL) from the facet of a GaAs substrate and in the vicinity of a SiN stripe are reported and analyzed. The deformation induced by the SiN stripe is estimated by fitting the measured DOP to 3D finite element method (FEM) simulations. The deformation is found to be more complex than an initial condition of biaxial stress in the SiN. A ratio of fit coefficients suggests that the dependence of DOP on strain is described by equations presented in Appl. Opt. 59, 5506-5520 (2020). These equations give a DOP that is either proportional to a weighted difference of the principal components of strain in the measurement plane, or proportional to the shear strain in the measurement plane, depending on the chosen orientation of the measurement axes.

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Fichiers liés : optics-04-00019.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 23/03/2023
• Auteurs : Philippe CouvertPhilippe GiralPierre -Yves BoelleValérie CarreauSophie BéliardJean -Marc LacortePhilippe LesnikFrancois PaillardRené ValéroAnnelies RotthierÉric BruckertAlain Carrié
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases

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• Type de publi. : Article dans une revue
• Date de publi. : 23/03/2023
• Auteurs : Charlotte BoussardLaure DelageTania GajardoAlexandre KauskotMaxime BatignesNicolas GoudinMarie-Claude StolzenbergCamille BrunaudPatricia PanikulamQuentin RillerMaryse Moya-NilgesJean SolarzChristelle ReperantBéatrice DurelJean-Claude BordetOlivier PelléCorinne LebretonAude MagérusVithura PirabakaranPablo VargasSébastien DupichaudMarie JeanpierreAngélique VinitMohammed ZarhrateCécile MassonNathalie AladjidiPeter ArkwrightBrigitte Bader-MeunierSandrine Baron JolyJoy BenadibaElise BernardDominique BerrebiChristine BodemerMartin CastelleFabienne Charbit-HenrionMarwa ChbihiAgathe DebrayPhilippe DrabentSylvie FraitagMiguel HiéJudith Landman-ParkerLudovic LhermitteDespina MoshousPierre RohrlichFrank RuemmeleAnne Welfringer-MorinMaud TusseauAlexandre BelotNadine N. Cerf-BensussanMarie RoelensCapucine PicardBénédicte NevenAlain FischerIsabelle CallebautMickaël MénagerFernando Sepulveda GarridoFrédéric AdamFrédéric Rieux-Laucat
• Organismes : Hémostase, Inflammation, Thrombose Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling [CIRI] Hospices Civils de Lyon Activation et transduction du signal dans les lymphocytes - Lymphocyte activation and signaling [CIRI] Hospices Civils de Lyon Hémostase, Inflammation, Thrombose
• Publié dans Blood le 28/10/2020

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Résumé : Dedicator of cytokinesis (DOCK) proteins play a central role in actin cytoskeleton regulation. This is highlighted by the DOCK2 and DOCK8 deficiencies leading to actinopathies and immune deficiencies. DOCK8 and DOCK11 activate CDC42, a RHO-GTPase involved in actin cytoskeleton dynamics, among many cellular functions. The role of DOCK11 in human immune disease has been long suspected but has never been described so far. We studied eight male patients, from seven unrelated families, with hemizygous DOCK11 missense variants leading to reduced DOCK11 expression. The patients were presenting with early-onset autoimmunity, including cytopenia, systemic lupus erythematosus, skin, and digestive manifestations. Patients' platelets exhibited abnormal ultrastructural morphology and spreading as well as impaired CDC42 activity. In vitro activated T cells and B lymphoblastoid cell lines (B-LCL) of patients exhibited aberrant protrusions and abnormal migration speed in confined channels concomitant with altered actin polymerization during migration. A DOCK11 knock-down recapitulated these abnormal cellular phenotypes in monocytes-derived dendritic cells (MDDC) and primary activated T cells from healthy controls. Lastly, in line with the patients' autoimmune manifestations, we also observed abnormal regulatory T cells (Tregs) phenotype with profoundly reduced FOXP3 and IKZF2 expression. Moreover, we found a reduced T cell proliferation and an impaired STAT5B phosphorylation upon IL2 stimulation of the patients' lymphocytes. In conclusion, DOCK11 deficiency is a new X-linked immune-related actinopathy leading to impaired CDC42 activity and STAT5 activation, and associated with abnormal actin cytoskeleton remodeling as well as Tregs phenotype culminating in immune dysregulation and severe early-onset autoimmunity.

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Fichiers liés : S0006497123007139.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/03/2023
• Auteurs : Clara de GrooteOlivier CottencinPhilippe TisonClaire TriquetJean-Louis Nandrino
• Organismes : Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193
• Publié dans Memory le 28/10/2020

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Résumé : The study examined the personal sense of identity in alcohol use disorder (AUD) through the relation between autobiographical memories and individuals’ self-conception. The AUD detoxified patients and control participants were asked to create a list of self-statements to which they associated for the three main autobiographical memories illustrating them. The group variable was not associated with the number of positive self-statements, but it was associated with the number of negative self-statements. Furthermore, for the autobiographical memories cued by a positive self-statement, the group was related to the number of positive memories and general memories, while no relation was observed for the memories cued by a negative self-statement. Our results also support that AUD patients’ memories cued by self-statements are older and more alcohol-related. Hierarchical regression analyses in the AUD patients demonstrated that the use of adaptive emotional regulation strategies was the only significant predictor of the use of positive or negative self-statements.

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• Type de publi. : Article dans une revue
• Date de publi. : 21/03/2023
• Auteurs : Ana Maria Roxana PetrescuChunjing QiuMatthew J McgrathPhilippe PeylinGlen PetersPhilippe CiaisRona L ThompsonAki TsurutaDominik BrunnerMatthias KuhnertBradley MatthewsPaul PalmerOksana TarasovaPierre RegnierRonny LauerwaldDavid BastvikenLena Höglund-IsakssonW. WiniwarterGiuseppe EtiopeTuula AaltoGianpaolo BalsamoVladislav BastrikovAntoine BerchetPatrick BrockmannGiancarlo CiotoliGiulia ConcheddaMonica CrippaFrank DentenerChristine D Groot ZwaaftinkDiego GuizzardiDirk GüntherJean-Matthieu HaussaireSander HouwelingGreet Janssens-MaenhoutMassaer KouyateAdrian LeipAntti LeppänenEmanuele LugatoManon MaisonnierA. ManningTiina MarkkanenJoe McnortonMarilena MunteanGabriel D OreggioniPrabir K. PatraLucia PeruginiIsabelle PisonMaarit T RaivonenMarielle SaunoisArjo SegersPete SmithEfisio SolazzoHanqin TianFrancesco TubielloTimo VesalaGuido R van der WerfChristopher WilsonS. Zaehle
• Organismes : Vrije Universiteit Amsterdam [Amsterdam] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Modélisation des Surfaces et Interfaces Continentales Norsk Institutt for Luftforskning Finnish Meteorological Institute School of Geosciences [Edinburgh] Centre for Exoplanet Science Ecologie fonctionnelle et écotoxicologie des agroécosystèmes Department of Thematic Studies – Technology and Social Change International Institute for Applied Systems Analysis [Laxenburg] University of Zielona G ́ora, Institute of Environmental Engineering, Licealna Str. 9, PL-65-417, Zielona G ́ora, Poland International Institute for Applied Systems Analysis [Laxenburg] University of Zielona G ́ora, Institute of Environmental Engineering, Licealna Str. 9, PL-65-417, Zielona G ́ora, Poland Istituto Nazionale di Geofisica e Vulcanologia - Sezione di Roma Finnish Meteorological Institute
• Publié dans Earth System Science Data le 23/10/2020

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Résumé : Knowledge of the spatial distribution of the fluxes of greenhouse gases (GHGs) and their temporal variability as well as flux attribution to natural and anthropogenic processes is essential to monitoring the progress in mitigating anthropogenic emissions under the Paris Agreement and to inform its global stocktake. This study provides a consolidated synthesis of CH4 and N2O emissions using bottom-up (BU) and top-down (TD) approaches for the European Union and UK (EU27 + UK) and updates earlier syntheses (Petrescu et al., 2020, 2021). The work integrates updated emission inventory data, process-based model results, data-driven sector model results and inverse modeling estimates, and it extends the previous period of 1990-2017 to 2019. BU and TD products are compared with European national greenhouse gas inventories (NGHGIs) reported by parties under the United Nations Framework Convention on Climate Change (UNFCCC) in 2021. Uncertainties in NGHGIs, as reported to the UNFCCC by the EU and its member states, are also included in the synthesis. Variations in estimates produced with other methods, such as atmospheric inversion models (TD) or spatially disaggregated inventory datasets (BU), arise from diverse sources including within-model uncertainty related to parameterization as well as structural differences between models. By comparing NGHGIs with other approaches, the activities included are a key source of bias between estimates, e.g., anthropogenic and natural fluxes, which in atmospheric inversions are sensitive to the prior geospatial distribution of emissions. For CH4 emissions, over the updated 2015-2019 period, which covers a sufficiently robust number of overlapping estimates, and most importantly the NGHGIs, the anthropogenic BU approaches are directly comparable, accounting for mean emissions of 20.5 TgCH(4) yr(-1) (EDGARv6.0, last year 2018) and 18.4 TgCH(4) yr(-1) (GAINS, last year 2015), close to the NGHGI estimates of 17 :5 +/- 2 :1 TgCH(4) yr(-1). TD inversion estimates give higher emission estimates, as they also detect natural emissions. Over the same period, high-resolution regional TD inversions report a mean emission of 34 TgCH(4) yr(-1). Coarser-resolution global-scale TD inversions result in emission estimates of 23 and 24 TgCH(4) yr(-1) inferred from GOSAT and surface (SURF) network atmospheric measurements, respectively. The magnitude of natural peatland and mineral soil emissions from the JSBACH-HIMMELI model, natural rivers, lake and reservoir emissions, geological sources, and biomass burning together could account for the gap between NGHGI and inversions and account for 8 TgCH(4) yr(-1). For N2O emissions, over the 2015-2019 period, both BU products (EDGARv6.0 and GAINS) report a mean value of anthropogenic emissions of 0.9 TgN(2)Oyr(-1), close to the NGHGI data (0 :8 +/- 55% TgN(2)Oyr(-1)). Over the same period, the mean of TD global and regional inversions was 1.4 TgN(2)Oyr(-1) (excluding TOMCAT, which reported no data). The TD and BU comparison method defined in this study can be operationalized for future annual updates for the calculation of CH4 and N2O budgets at the national and EU27 C UK scales. Future comparability will be enhanced with further steps involving analysis at finer temporal resolutions and estimation of emissions over intra-annual timescales, which is of great importance for CH4 and N2O, and may help identify sector contributions to divergence between prior and posterior estimates at the annual and/or inter-annual scale. Even if currently comparison between CH4 and N2O inversion estimates and NGHGIs is highly uncertain because of the large spread in the inversion results, TD inversions inferred from atmospheric observations represent the most independent data against which inventory totals can be compared. With anticipated improvements in atmospheric modeling and observations, as well as modeling of natural fluxes, TD inversions may arguably emerge as the most powerful tool for verifying emission inventories for CH4, N2O and other GHGs. The referenced dataset srelated to figures are visualized at https://doi.org/10.5281/zenodo.7553800 (Petrescu et al., 2023).

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Fichiers liés : Petrescu-ESSD-2023-CC-BY.pdf

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