Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Pierre-Régis BurgelJennifer da SilvaEmmanuelle GirodonIsabelle DurieuMartine Reynaud-GaubertMarlene Murris-EspinRaphael ChironDominique GrenetSophie RamelLaurent MelyRebecca HamidfarBenoit DouvryVéronique HoudouinCamille AudoussetJulie MaceyMarie MittaineLaurence WeissLaure CossonIsabelle Danner-BoucherPhilippe ReixMélisande BaravalleEspérie BurnetIsabelle Sermet-GaudelusClémence MartinJean-Louis PaillasseurClaire AndréjakClaire PouletCinthia RamesPascaline PriouFrançoise TroussierBénédicte Richaud-ThiriezMarie-Laure DalphinAlice LadauradeJulie MaceyClaire BonStephanie BuiMickael FayonKarine CampbellMuriel LauransSylvie MontcouquiolGuillaume LabbeBenoit DouvryRalph EpaudNatascha RemusAnnlyse FantonFrédéric HuetAmale Boldron-GhaddarManuela ScalbertCélia TillardLaurent MelyRébecca HamidfarSébastien QuetantCatherine LlerenaSophie ValoisCamille AudoussetThierry PerezNathalie Wizla-DerambureCaroline ThumerelleMagali Dupuy-GrassetJeanne LanguepinAlexandra Masson-RouchaudIsabelle DurieuRaphaële Nove-JosserandQuitterie ReynaudMaël RichardPhilippe ReixCamille OhlmannThomas PerrinTom ToinMarie-Christine Werck-GalloisMartine Reynaud-GaubertBérengère ColteyNadine Desmazes-DufeuJean-Christophe DubusMélisande BaravalleNathalie StremlerRaphaël ChironFloriane SocchiAnne GuillaumotAurélie TatopoulosSébastien KieferIsabelle Danner-BoucherAdrien TissotTiphaine Roussey-BihoueeMyriam BenhamidaSylvie LeroyWael AlkoussaSarah MarchalPierre-Régis BurgelNicolas CarlierJohanna FesenbeckhIsabelle HonoréReem KanaanClémence MartinIsabelle Sermet-GaudelusFrédérique ChedevergneVéronique HoudouinLaurence Le ClaincheSophie MayerHarriet CorvolSophie DenamurJessica TaytardGuillaume ThouveninKatia Bessaci-KabouyaSandra DuryChantal BelleguicEric DeneuvilleMarie JaminSophie RamelJean Le BihanChristophe MarguetStéphane DominiqueHélène Morisse-PradierStéphanie PramilLaure CoudercElsa GachelinJuliette VerhilleCaroline PerissonRomain KesslerLoïc KassegneMichele PorzioLaurence WeissDominique GrenetSylvie Colin-De-VerdiereSandra de MirandaMarlène Murris-EspinMarion DupuisMarie MittaineLéa RoditisJulie MankikianThomas FlamentLaure CossonCharlotte GirautBaptiste ArnouatAsma GabsiDelphine PouradierAnne-Sophie Bonnel
• Organismes : Institut Cochin Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Research on Healthcare Performance Assistance Publique - Hôpitaux de Marseille Service Pneumologie-Allergologie [CHU Toulouse] Centre de Ressources et de Compétences en Mucoviscidose [CHU Toulouse] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Foch [Suresnes] Service de pneumologie [Hôpital Foch] Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) Hôpital Renée Sabran [CHU - HCL] Centre Hospitalier Universitaire [CHU Grenoble] Centre Hospitalier Intercommunal de Créteil Département de pneumologie pédiatrique [CHU Créteil] AP-HP Hôpital universitaire Robert-Debré [Paris] Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Universitaire de Bordeaux Service Gastroentérologie, hépatologie nutrition, diabétologie et maladies héréditaires du métabolisme pédiatrique [CHU Toulouse] Université Paris Cité Centre Hospitalier Régional Universitaire de Tours Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hospices Civils de Lyon Hôpital Femme Mère Enfant [CHU - HCL] Centre National de la Recherche Scientifique Université Claude Bernard Lyon 1 Université Paris Cité Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 CHU Amiens-Picardie Research on Healthcare Performance Génétique, génomique fonctionnelle et biotechnologies (UMR 1078)
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Liem Binh Luong NguyenLyvia MagloireAlexis FrançoisDavid BillardFrank PriouJennifer ArrondeauClaude LinassierInes Ben GhezalaMarine Gross-GoupilJulie CharlesNadine DohollouPhilippe VanhemsClaire CracowskiAnne Marie LeroiFabrice LainéFlorence GaltierKarine BarthelemyStéphane PrietMariam GharibMathieu ChalouniAude BarquinPaul LoubetXavier de LamballerieOdile LaunayLinda WittkopJean-Yves BlayJean-Philippe Spano
• Organismes : CIC Cochin Pasteur F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Université de Bordeaux Université de Bordeaux Hôpital Foch [Suresnes] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Cancer Research and Personalized Medicine - CARPEM [Paris] Centre Hospitalier Régional Universitaire de Tours Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques CHU Dijon Hôpital Saint-André [Bordeaux] F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Centre Hospitalier Universitaire [CHU Grenoble] Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Polyclinique Bordeaux Nord Aquitaine Hôpital Edouard Herriot [CHU - HCL] Université Claude Bernard Lyon 1 Centre d'Investigation Clinique [Grenoble] Centre d'Investigation Clinique [CHU Rouen] Service de Physiologie Digestive, Urinaire, Respiratoire et de l'Exercice [CHU Rouen] Centre d'Investigation Clinique [Rennes] Hôpital Sud [CHU Rennes] CIC Montpellier Hôpital Saint Eloi [CHU Montpellier] Unité des Virus Emergents Unité des Virus Emergents ANRS - Maladies infectieuses émergentes Université de Bordeaux Université de Bordeaux Centre Hospitalier Universitaire de Nîmes Virulence Bactérienne et Infections Chroniques F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) Unité des Virus Emergents F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC) CIC Cochin Pasteur Centre Hospitalier Universitaire de Bordeaux Institut Bergonié [Bordeaux] CIC Bordeaux Statistics In System biology and Translational Medicine Centre Léon Bérard [Lyon] Université Claude Bernard Lyon 1 Environnement, Mobilité et Santé [iPLesp] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Vaccine le 26/10/2020

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Résumé : Background: Patients with cancer, whose immune responses to vaccines are commonly weaker than those of the general population, are recommended a booster dose after two initial doses of Covid-19 vaccine. Our objective was to compare the humoral immunogenicity of Covid-19 vaccines in patients with cancer compared to healthy adults (control group) after primary vaccine series and after a booster dose. Methods: We included participants aged ≤75 and vaccinated with two doses in the primary vaccine series and a booster, from the French national prospective Covid-19 vaccine cohort study (ANRS0001S COV-POPART) and excluded those with SARS-CoV-2 infection. Percentage of responders, geometric mean titers (GMT) of anti-SARS-CoV-2 IgG antibodies (ELISA) and specific neutralizing antibodies against original strain, Delta and Omicron variants of concern, were estimated one month after the primary vaccine series, then one month and six months after a booster dose. Results: We included 183 patients with cancer and 1173 controls. The most frequent cancers were breast (37.2 %) and lung cancer (17.5 %). Patients with cancer were older and had lower anti-Spike IgG levels after the primary vaccine series (GMT = 132.4 vs 332.7 BAU/mL, P < 0.0001), but they developed similar response at one month (GMT = 2146.1 vs 1841.3 BAU/mL], P = 0.16) and six months after booster (602.0 vs 574.4 BAU/mL, P = 0.80). Neutralizing antibodies levels confirmed these results. Conclusion: Patients with cancer have comparable response rates to controls one month and six months after a booster dose. Our results support the benefit of a booster dose in patients with cancer.

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Fichiers liés : 1-s2.0-S0264410X25009302-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Clément DesjardinsStéphan GrimaldiSheng LuoLuowen YuChristopher GoetzGlenn StebbinsPablo Martinez-MartinMonica KurtisTiago MestreAlvaro Sanchez-FerroMichelle H.S. TosinRoberta BalestrinoChi‐ying LinCarmen Gasca-SalasTatiana WitjasOlivier ColinDavid MalteteLuc DefebvreCaroline GiordanaMahmoud CharifClaire ThiriezChloé LaurencinFazia Mélissa TirGwendoline DupontPhilippe RemyChristine TranchantSophie DrapierAlexandra SamierIsabelle BenatruSara SambinJean-Christophe CorvolFatma KhelifiMargherita FabbriOlivier J. Rascol
• Organismes : Hôpital Avicenne [AP-HP] Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] Centre de résonance magnétique biologique et médicale Beijing Key Lab of Digital Plant Duke University [Durham] Institute of Health Carlos III Centro de Investigacion Biomédica en Red sobre Enfermedades Neurodegenerativas Hospital Ruber Internacional [Madrid, Spain] Institut de Neurosciences de la Timone CHU Rouen Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Centre Hospitalier Universitaire de Nice Centre Hospitalier Régional Universitaire [Montpellier] Institut des Neurosciences de Montpellier Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Pathophysiologie de la maladie de Parkinson et des troubles associés CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Institut Mondor de Recherche Biomédicale Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Centre d’Excellence en Maladies Neurodégénératives Centre d’Excellence en Maladies Neurodégénératives
• Publié dans Movement Disorders Clinical Practice le 01/02/2019

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Lucie CrosAntoine GusdorfPhilippe SaloméSergiy StepkinPhilippe ZarkaPedro SalasAlan LohPierre LesaffreJonathan FreundlichMarta AlvesFrancois BoulangerAndrea BraccoStéphane CorbelMaryvonne GerinJavier R. GoicoecheaIsabelle GrenierJean-Mathias GriessmeierMartin HoudeOleksandr KonovalenkoAntoine MarchalAlexandre MarcowithFlorent MertensFrédérique MotteMichel TaggerAlexander TielensG TheureauPeter TokarskyOleg UlyanovVyacheslav Zakharenko
• Organismes : Astrophysique Laboratoire de physique de l'ENS - ENS Paris Laboratoire d’étude de l’Univers et des phénomènes eXtrèmes Laboratoire de physique de l'ENS - ENS Paris Laboratoire d’Instrumentation et de Recherche en Astrophysique National Radio Astronomy Observatory [Green Bank] Laboratoire d’Instrumentation et de Recherche en Astrophysique Laboratoire de physique de l'ENS - ENS Paris Observatoire astronomique de Strasbourg Laboratoire de physique de l'ENS - ENS Paris Astrophysique Astrophysique Astrophysique Interprétation Modélisation Laboratoire d’étude de l’Univers et des phénomènes eXtrèmes Instituto de Fisica Fundamental, CSIC Astrophysique Interprétation Modélisation Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Department of Physics and Astronomy [London, ON] Institute of Radio Astronomy of NAS of Ukraine Research School of Astronomy and Astrophysics [Canberra] Laboratoire Univers et Particules de Montpellier Laboratoire d’étude de l’Univers et des phénomènes eXtrèmes Institut de Planétologie et d'Astrophysique de Grenoble Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Leiden Observatory [Leiden] Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Institute of Radio Astronomy of NAS of Ukraine Institute of Radio Astronomy of NAS of Ukraine Institute of Radio Astronomy of NAS of Ukraine Laboratoire de Physique et Chimie de l'Environnement et de l'Espace
• Publié dans Astronomy & Astrophysics - A&A le 28/10/2020

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Résumé : Context. Carbon radio recombination lines (CRRLs) at decametre wavelengths trace the diffuse phase of the interstellar medium (ISM) of the Galaxy. Observations of these lines allow for physical parameters of this phase to be measured.Aims. We observed CRRLs with the recently commissioned New Extension in Nançay Upgrading LOFAR (NenuFAR) telescope towards two of the brightest sources at low-frequency (10–85 MHz): Cassiopeia A and Cygnus A (hereafter, Cas A and Cyg A, respectively). We then measured the density, ne, and temperature, Te, of the electrons in line-of-sight clouds.Methods. We used NenuFAR’s beam-forming mode and integrated several tens of hours on each source. The nominal spectral resolution was 95.4 Hz. We developed a reduction pipeline primarily aimed at removing the radio frequency interference (RFI) contamination and correcting the baselines. We then performed a first fitting of the spectral lines observed in absorption associated with the line-of-sight clouds.Results. Cas A is the brightest source in the sky at low frequencies and represents an appropriate test bench for this new telescope. On this source, we detected 398 Cα lines between the principal quantum numbers n = 426 and n = 826. Cyg A is also a bright source, however, the Cα lines were observed to be fainter. We stacked the signal by groups of a few tens of lines to improve the quality of our fitting process. For both sources, we reached a significantly higher signal-to-noise ratio (S/N) and spectral resolution than the most recent detections by the LOw Frequency ARray (LOFAR). The variation of the spectral line widths with the electronic quantum number provides constraints on the physical properties of the clouds: Te, ne, and the temperature, T0, of the radiation field, the mean turbulent velocity, νt, and the typical size of the cloud.Conclusions. Our final constraints differ from those inferred from LOFAR results, with ∼50% lower Te, ∼35% lower ne, and from 10 to 80% higher νt, on average. The NenuFAR observations sample a larger space volume than LOFAR’s towards the same sources due to the differences in instrumental beam sizes. These discrepancies highlight the sensitivity of low-frequency CRRLs as probes of the diffuse ISM, paving the way towards large area surveys of CRRLs in our Galaxy.

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Fichiers liés : aa55085-25.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Romain StammlerAlexandre ValléeJulien RohmerNathalie GrardelNoémie AbisrorWadih Abou ChahlaFélix AckermannAntoine BaudetNabil BelfekiRaouf Ben AbdelaliAudrey BidetJean-Sébastien BladéSéverine BleuseBernard BonnotteMohammed Azzedine BouderbalaJean-Michel CayuelaSafia ChebrekJérémie DionAntoine DossierNicolas DuployezStanislas FaguerPascale Flandrin-GrestaLionel GalicierCatherine GodonMaximilien GrallVincent JachietMathieu JouvrayIrina LatuEmmanuel LedoultEtienne LenglineAmélie LeursLudovic LhermitteFrançois LifermannNicolas LimalBertrand LiogerMaxime LugosiIrène MachelartMickaël MartinNihal MartisLaurent MauvieuxSara Melboucy-BelkhirCatherine MohrGuillaume MoulisMarie Joelle MozicconacciDina NaguibAntoine NéelFranck NicoliniRoderau OuthKewin PanelClaude PreudhommeMathieu PuyadeThomas QuemeneurViviane Queyrel MoranneJérôme ReyPhilippe RousselotNicolas SchleinitzBorhane SlamaDelphine Staumont-SalléCamille TailléLouis TerriouLudovic TrefondJean François ViallardJean-Emmanuel KahnGuillaume LefèvreMatthieu GrohSébastien AbadHenri Abi RachedAmir AdedjoumaDidier AdikoChristian AgardKais AhmadNuri AhwijJean-Christophe AlloZineb AmraniAchille AoubaHélène AubertNathalie BaizeAndré BaruchelCaroline BealIssam BelhajMaxime BembaAlice BerezneClément BeuvonMarie Beylot BarryOdile Beyne RauryPhilip BielefeldConstance BlandinMario BoisseauCaroline BonmatiCécile BorelDaoud BouredjiHélène BoutrouxAnne BrignierBenoit BrihayeMarc BrouillardThomas BrunetClaude-Eric BulaboisFrance CamposMartin CarreEmilie ChalayerCécile ChenivesseJean Claude ChomelValérie CoiteuxThibaut ComontAdrien ContejeanVincent CottinAmélie Couteau ChardonPriscille CoutureYoann CrabolGwenvael DanicAdrien DanielStéphane DarreSebastien de AlmeidaAdèle de MassonEric DelabesseThomas DelayeFréderic DezoteuxViviane DubruilleClairelyne DupinMylène DuplanCécile Audrey DurelMikaël EbboJaphete Darline Elenga KoengaAberrazak El YamaniAlexandra EspitiaPascaline EtancelinGabriel EtienneNicolas EtienneMarine EustachePhilippe EvonOlivier FainSophie Georgin LavialleBertrand GodeauCécile GoldenTiphaine GoulenokClément GourguechonCarine GreibAurélien GuffroyPhilippe GuilpainEmmanuel GyanEric HachullaMarion HermetFrançoise HuguetLucas InchiappaIbrahim JdidElisa JolyKatayoun JondeauMorgane JoubertAnne JourdainMathieu JouvrayGalith KalmiBrigitte LagrangeNoémie Le GouellecCaroline LejeuneSarah Le NaourMathilde LeclercqPaul LegendreClaire Le PenduFaustine LhommeOlivier LidoveElena LopinetPierre LozachAurélie MadelonLéa MairotFréderic MaloiselAnne MarfaingVictor MargelidonIbrahim MarrounAgathe MasseauFrançois MaurierArsène MekinianMathieu MeunierMarc MichelChafika Morati-HafsaouiThierry MuronAlexandre NguyenHubert NiellyMario OjedaThomas PapoRomain PauleArnaud PetitJean Michel PignonSabine RevuzSophie RigaudeauEtienne RiviereCédric RossiManon RoucoulesJean-Philippe RougierMathilde RoumierArnaud Saint LezerLaurent SaillerGaetan SauvetreLéa SaveyQuentin ScanvionLaurent SchwarbDamien SèneLaurence SimonBohrane SlamaMicha SrourFelipe SuarezBenjamin SubranSuzanne TavitianColas TcherakianNathalie TieulieJose Miguel TorregrosaElise ToussaintJulie TrichereauRémi VatanGael VaudourAlexandre VlakosSorin VisanicaLaurent VoilatFanny VuottoStéphanie WaninHacène ZerazhiJean Marc ZiniStéphane Zographos
• Organismes : Centre Hospitalier Régional Universitaire [CHU Lille] Institute for Translational Research in Inflammation - U 1286 Centre de Référence National des Syndromes Hyperéosinophiliques Infection et inflammation
• Publié dans Journal of Allergy and Clinical Immunology: In Practice le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Patrick Moretto-CapelleAnthony ScemamaStéphane FaureEszter DudásPierre CafarelliJean-Philippe Champeaux
• Organismes : Interactions Ions-Matière (LCAR) Groupe THEO (LCPQ) Laboratoire Collisions Agrégats Réactivité Interactions Ions-Matière (LCAR) Interactions Ions-Matière (LCAR) Interactions Ions-Matière (LCAR)
• Publié dans Physical Chemistry Chemical Physics le 02/11/2020

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Résumé :

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Fichiers liés : Dicationic hydantoin HAL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Olivier GrimaudEmmanuelle LeraySahar BayatChristophe FermanianSylvie MartinMyriam Maumy-BertrandJean-Marc PhilippeEric MauryAgnès Ricard-HibonPierre TattevinMarc NoizetFrançois BraunManuel DolzMarc-Antoine SanchezHélène Coignard-BiehlerNathalie PrietoHugues DelamareVirginie CayréPierre CarliAlbert VuagnatJulien PottecherAsaël BergerLaure Abensur VuillaumeGuillaume LouisHélène BeringuerSebastien GetteThierry CapsKhaldoun KuteifanChristian FuchsLionel NaceBruno MourvillierStéphane GennaiSonia FoalemClaudia CiurelCosimo BriganteLionel PopoffFarid ArezkiAnne WeissFerhat MezianiFrancis SchneiderPaul-Michel MertesPascal LexaBetty FleuryElisabeth GaertnerGaëtan PlantefeveHenri FaureGuillaume Gelé DecaudinYves CohenFréderic AdnetElie ZogheibCharles DamoiselMathieu BoutonnetEmmanuel WeissJean-Damien RicardGeorges-Antoine CapitaniMarie BaronFrédérique SchortgenArmand Mekontso DessapEric LecarpentierEvelina OchinArmelle SeverinThomas LoebNicholas HemingPierre MoineDjillali AnnaneFabrice BertrandPhilippe DurandLucille WildenbergAnatole HarroisJean-Louis TeboulMartial ThyraultSabrine NakaaSophie Guilmin-CreponStéphane DaugerMarie BorelMatthieu LangloisAnne-Charlotte GianinazziFranck VerdonkBruno MégarbaneMuriel FartoukhLionel LamhautCédric BruelEmmanuel GuérotAlexy Tran DinhNathalie ZappellaTiphaine GirardPhilippe MontraversJean-Louis DubostMarie GrangeonGaël PitonSébastien Pili-FlouryThibault DesmettreToufiq El CadiBérengère VivetMarie ClavierDavid CoregeJean-François CicalaPaul-Simon PugliesiJean-Paul DenisEléonore TimsitSébastien MirekMohamed DyaniRené-Gilles PatrigeonBernard LecomteLaura FedericiLaurent SerpinPierre CalligeClément DubostOlivier RichardVirginie LaurentPhilippe IchaiJulio BadieMorlaye SanoBenoît PlaudMichael DarmonElie AzoulayDaniel da SilvaMourad LakhdariAlexandre BoyerDavid Tran VanCamille FoucaultThierry MayetQuentin LevratCédric DarreauPierre-Yves CordierRaphaël ParisMarie SouryMaxime GarnierPatrick LafforgueRomaric GrenotArnaud ThillePierre KergoatPhilippe GoutorbeFanny Bounes-VardonAntoine GalyOlivier de SoyresTahar SaghiHubert GrandLaurent MullerHélène CharbonneauKevin QuesnelJérôme PillotFrançois-Michel BelonclePierre AsfarSigismond LasockiDavid SchnellAnne RenaultOlivier HuetClaude CohenMarion CostecaldeElodie BrunelPhilippe PetuaAudrey DestizonsCaroline PoupletAntoine RoquillyJean ReignierBertrand SouweineJean-Etienne BazinJennifer BrunetJean-Baptiste MichotAurélien SeemannFabienne TamionFrancis RemerandPierre-François DequinAdel MaamarYoann LauneyPierre-Thierry PiechaudAurélien FrerouGuillaume SchnellPierre FillatreChloé ThillGuillaume GrilletPierre-Yves EgreteauJohann AuchabiePierre-Louis DeclercqBenoît RozeMarc-Olivier FischerLoïc DopeuxRamin RavanLuc JarrigeChristophe FaisyBertrand SauneufNicolas PichonFabrice PrevostAgathe DelboveMaud JonasSandrine Bedon CarteGaël PradelAntoine Vieillard-BaronSalah BoussenMarc GainnierSamuel LehingueMarie-Christine HeraultMichel DurandPhilippe DeswardtPhilippe CamarasaCarole IchaiJean-Emmanuel AlphonsineBruno MarquerVincent WillemsAlexandre RobertPierre-Marie BertrandNadiejda AntierToufic FingeLucie MoutonTouraj RastegarTobias GrafJean ReuterClaude BraunStephan WatremezUwe SpetzgerAndré MichelMarc Bodenstein
• Organismes : Recherche en Pharmaco-épidémiologie et Recours aux Soins Département Méthodes quantitatives en santé publique École des Hautes Études en Santé Publique Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé Université de Rennes Centre d'Investigation Clinique [Rennes] Recherche en Pharmaco-épidémiologie et Recours aux Soins Département Méthodes quantitatives en santé publique École des Hautes Études en Santé Publique Arènes: politique, santé publique, environnement, médias Recherche sur les services et le management en santé Université de Rennes Arènes: politique, santé publique, environnement, médias École des Hautes Études en Santé Publique Département Méthodes quantitatives en santé publique Recherche sur les services et le management en santé Université de Rennes Arènes: politique, santé publique, environnement, médias École des Hautes Études en Santé Publique Département Méthodes quantitatives en santé publique Recherche sur les services et le management en santé Université de Rennes Arènes: politique, santé publique, environnement, médias École des Hautes Études en Santé Publique Département Méthodes quantitatives en santé publique Recherche sur les services et le management en santé Université de Rennes Arènes: politique, santé publique, environnement, médias École des Hautes Études en Santé Publique Département Méthodes quantitatives en santé publique Recherche sur les services et le management en santé Ministère des Affaires sociales et de la Santé Direction Générale de la Santé Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie Département Urgences SAMU-SMUR 95, CHG Pontoise-Beaumont/Oise, Pontoise, France Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Groupe hospitalier de la région de Mulhouse et Sud-Alsace Centre hospitalier régional de Metz-Thionville Direction centrale du service de santé des armées Direction des Systèmes d’Information et du Numérique (DSIN), Service de Santé des Armées Françaises, Saint-Mandé-, France Service de Santé des Armées Service médical d’urgence, CHU de Lyon Hôpital Edouard Herriot [CHU - HCL] Santé publique France Antilles Agence Régionale de Santé Grand-Est SAMU 75 [Paris] Hôpital Necker - Enfants Malades [AP-HP] Drees, Ministère des affaires sociales et de la santé Hôpitaux Universitaires de Strasbourg TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group TRANSCOV-study group
• Publié dans Chest le 29/10/2020

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Résumé : Background: In a context of overwhelming demand, mass transfers between intensive care units (ICU) were organized in France during the first COVID-19 epidemic wave (spring 2020). According to early reports, transferred patients experienced a 3-to-4-fold lower ICU case fatality. It is not known whether this difference stems only from the selection of healthier patients for transfer. Research question: Is the 28-day ICU case fatality of transferred patients different from that of matched control (not transferred) patients? Study design and methods: Multicenter retrospective cohort study that included 285 transferred patients, and 667 control (not transferred) patients admitted simultaneously (± 2 days) to the same "origin" ICU and alive five days after the transfer date. The 28-day ICU case fatality and clinical events during ICU stay were compared in transferred and control patients. Results: At ICU admission, age, COVID-19 severity, comorbidities and Simplified Acute Physiology Score II (SAPS II) were similar, but transferred patients were lighter (81 versus 89 kg, p<0.0001) and more autonomous than the matched control patients (64.5 versus 55.0%, p=0.01). Case fatality was approximately 7-fold lower in transferred patients (adjusted incidence rate ratio = 0.14 [95% CI: 0.10-0.19]). ICU stay was longer and delirium, psychiatric disorders and neuromuscular blockade exposure were more frequent in transferred patients than controls. Conversely, acute kidney injury was more frequent in controls (51.5 versus 37.7%, p<0.0001). Interpretation: Although the selection of healthier patients likely contributed to better survival, removal from an overcrowded care environment probably also explains the large survival benefit associated with transfer. By reducing workload, mass transfers might have also benefited patients who remained in origin ICUs. Organizing mass transfers as early as possible may be an appropriate strategy for mitigating the impact of an overwhelming intensive care demand.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Martin FaureLouis Le BivicMarouane BoukhrisAndrea CianciJean-David BlossierDounia MeddadLucie ChastaingtPhilippe LacroixJérôme JouanPierre-Marie PreuxNicole DarodesVictor AboyansJulien Magne
• Organismes : CHU Limoges Epidémiologie des Maladies Chroniques en zone tropicale Service de cardiologie [CHU Limoges] Service de cardiologie [CHU Limoges] Service de cardiologie [CHU Limoges] Service de cardiologie [CHU Limoges] Epidémiologie des Maladies Chroniques en zone tropicale Epidémiologie des Maladies Chroniques en zone tropicale Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges] Epidémiologie des Maladies Chroniques en zone tropicale Hôpital Dupuytren [CHU Limoges] CHU Limoges Epidémiologie des Maladies Chroniques en zone tropicale Service de cardiologie [CHU Limoges] Epidémiologie des Maladies Chroniques en zone tropicale Service de cardiologie [CHU Limoges] Université de Limoges Epidémiologie des Maladies Chroniques en zone tropicale
• Publié dans Archives of cardiovascular diseases le 30/10/2020

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Résumé : Background Due to common pathophysiology and shared risk factors, peripheral artery disease (PAD) is frequently present in patients with calcific aortic stenosis (AS). However, the prevalence of PAD in calcific AS and its prognostic impact require further investigation. Aims To describe the prevalence of PAD in patients with advanced AS requiring intervention and assess the impact of PAD on overall long-term mortality among patients undergoing transcatheter aortic valve replacement (TAVR). Methods All patients who underwent TAVR between 2014 and 2023 in our tertiary care centre were enrolled in a retrospective cohort. PAD was defined by the mention of a clinical diagnosis in medical records, significant arterial stenosis observed on the pre-procedural angio-computed tomography scan or a history of lower-limb revascularization. Results Among the 904 included patients (median [interquartile range] age 84.2 (79.9–87.4) years, 54.4% male), 212 (23.5%) had PAD. Patients with PAD had a significantly higher risk of mortality compared to patients without PAD (mean 5-year survival 40.0%, 95% confidence interval [CI] 32.2–49.6 vs. 52.7%, 95% CI 47.8–58.1; P = 0.008; adjusted hazard ratio [aHR] 1.31, 95% confidence interval [CI] 1.03–1.66; P = 0.029). Among patients without coronary artery disease (CAD), those with PAD alone had an increased risk of mortality (aHR 1.50, 95% CI 1.03–2.21; P = 0.037). Importantly, patients with PAD alone had significantly reduced survival compared to those with CAD alone (i.e. without PAD) (aHR 1.49, 95% CI 1.02-2.19; P = 0.040). However, the survival of patients with both PAD and CAD did not significantly differ from those with CAD without PAD. Conclusion PAD was independently associated with increased mortality in severe calcific AS. Importantly, this excess mortality among patients with PAD was not affected by the simultaneous presence of CAD. Similarly to patients with CAD, patients with AS and concomitant PAD should be considered at high risk of mortality.

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Fichiers liés : Aortic stenosis.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Nicolas BonfantiP. CholerJean-Christophe ClementPierre BarréFrançois BaudinLauric CecillonAmélie SaillardWilfried ThuillerJérôme PoulenardNorine KhedimRomain Goury
• Organismes : Environnements, Dynamiques et Territoires de Montagne Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Laboratoire d'Ecologie Alpine Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Laboratoire de géologie de l'ENS Institut des Sciences de la Terre de Paris Laboratoire de géologie de l'ENS Ambassade de France au Kénya Laboratoire d'Ecologie Alpine Laboratoire d'Ecologie Alpine Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Laboratoire d'Ecologie Alpine
• Publié dans Geoderma le 25/10/2020

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Résumé : Estimating SOC stocks and stability, as well as modeling their response to rising temperatures, is crucial for predicting climate change impacts. This is particularly true in mountainous regions, where low temperatures slow down SOC decomposition, resulting in higher SOC stocks compared to soils at lower elevations. However, these stocks are also more vulnerable to warming, increasing the risk of SOC depletion. Such conditions create the potential for a positive feedback loop in which warming accelerates SOC losses, further amplifying climate change impacts on these sensitive ecosystems. To better understand the factors controlling SOC stocks and stability in mountain soils, we sampled 170 soil profiles along 29 elevation gradients in the western Alps from 280 to 3160 m a.s.l. We assessed SOC stocks and chemical composition using mid-infrared spectroscopy method and SOC stability with Rock-Eval® thermal analysis. Our findings, based on an unprecedented dataset, reveal a clear elevational pattern in SOC properties. SOC stocks increase with elevation up to the montane belt (1200–1500 m a.s.l.), remain relatively stable through the subalpine zone, and then decline beyond the subalpine/alpine boundary (2200–2400 m a.s.l.). Notably, this transition is also marked by a significant drop in SOC stability, suggesting a shift in the dominant stabilization processes at higher elevations. Our results also indicate that SOC stocks and stability are influenced by a complex interplay of factors. At higher elevations, climate emerges to be the dominant factor, whereas lithology and weathering play a more significant role at lower elevations. These results suggest that at high-elevations, harsh climatic conditions favor stabilization of SOC, while less developed soils limit organo-mineral interactions. In contrast, at warmer, lower elevations with higher carbon fluxes, more developed soils facilitate organo-mineral interactions, thereby enhancing SOC stability in the long term. Consequently, alpine grasslands, which contain substantial stocks of labile carbon stabilized by climatic conditions, appear to be particularly vulnerable to the effects of climate warming.

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Fichiers liés : 1-s2.0-S0016706125002939-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2025
• Auteurs : Pierre NahonClovis Lusivika-NzingaPhilippe MerleFabien ZoulimThomas DecaensNathalie Ganne-CarriéGeorges-Philippe PageauxVincent LeroyLaurent AlricJean-Pierre BronowickiMarc BourlièreJérôme GournayAlbert TranStanislas PolPhilippe MathurinVéronique Loustaud-RattiSophie MétivierVictor de LedinghenArmand AbergelDominique ThabutLouis d'AlterocheMohammed BouattourTarik AsselahDenis OuzanPaul CalesOlivier ChazouillèresMoana Gelu-SimeonDominique RoulotJérôme BoursierCarole CagnotSonia TamazirtAlina PascaleSamuel NilusmasMaïté LewinMarianne ZiolFabrice CarratJean-Charles Duclos-Vallée
• Organismes : Centre de Recherche des Cordeliers Institut Pierre Louis d'Epidémiologie et de Santé Publique Centre de Recherche en Cancérologie de Lyon Centre de Recherche en Cancérologie de Lyon Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) Hôpital Avicenne [AP-HP] Centre de Recherche des Cordeliers Centre Hospitalier Régional Universitaire [Montpellier] Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB) Hôpital Henri Mondor Pharmacochimie et Biologie pour le Développement Nutrition-Génétique et Exposition aux Risques Environnementaux Service d'Hépato-gastro-entérologie [CHRU Nancy] Hôpital Saint-Joseph [Marseille] Institut des Maladies de l'Appareil Digestif Centre Hospitalier Régional Universitaire [CHU Lille] Université Côte d'Azur Hôpital Archet 2 [Nice] Centre méditerranéen de médecine moléculaire Service d'hépatologie médicale [CHU Cochin] Université Paris Descartes - Paris 5 Institute for Translational Research in Inflammation - U 1286 Biologie moléculaire et cellulaire des microorganismes Service de Bactériologie, Virologie, Hygiène [CHU Limoges] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Bordeaux Université de Bordeaux CHU Clermont-Ferrand CHU Pitié-Salpêtrière [AP-HP] Centre de recherche en épidémiologie et santé des populations Sorbonne Université CHU Trousseau [Tours] Hôpital Beaujon [AP-HP] Centre de recherche sur l'Inflammation Hôpital Beaujon [AP-HP] Centre de recherche sur l'Inflammation Institut Arnault Tzanck Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques Centre Hospitalier Universitaire d'Angers CHU Saint-Antoine [AP-HP] Institut de recherche en santé, environnement et travail CHU Pointe-à-Pitre / Abymes [Guadeloupe] Centre de Recherche des Cordeliers AP-HP - Hôpitaux Universitaires Paris Seine-Saint-Denis Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire [CHU Grenoble] ANRS - Maladies infectieuses émergentes Physiopathologie et traitement des maladies du foie Physiopathologie et traitement des maladies du foie Institut Pierre Louis d'Epidémiologie et de Santé Publique Centre Hépato-Biliaire [Hôpital Paul Brousse] Assistance publique - Hôpitaux de Paris (AP-HP) Centre de Recherche des Cordeliers Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Centre hépato-biliaire Physiopathologie et traitement des maladies du foie
• Publié dans Journal of Hepatology le 23/10/2020

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Résumé : Background & aims: Whether the dynamics of non-invasive tests (NITs) correlate with hepatocellular carcinoma (HCC) risk in patients with cirrhosis following sustained virological response (SVR) remains unknown. Thus, we aimed to describe NIT dynamics and assess their correlation with HCC risk. Methods: The dynamics of NITs (fibrosis-4 index [FIB-4], aspartate aminotransferase-to-platelet ratio index [APRI] and liver stiffness measurement) were described in patients with cirrhosis after SVR included in two prospective French multicenter cohorts (ANRS CO22 Hepather and CO12 CirVir) between 2006 and 2015. To assess their relationship with the risk of HCC, a joint modeling approach was employed using both standard and flexible models adjusted for age and sex. The impacts of NIT current value and slope during follow-up on HCC risk were assessed, considering competing risks of death. Results: A total of 3,067 patients with cirrhosis who achieved SVR were analyzed, among whom 228 (7.4%) developed HCC and 210 (6.9%) died during a 26-month follow-up. All NITs were increased at baseline in patients who ultimately developed HCC, whereas platelet counts were lower. All NITs improved in patients who did not develop HCC. More varied changes were observed during the follow-up of patients who ultimately developed HCC. Joint model analyses showed that current values of FIB-4, APRI and platelet count at any time impacted HCC risk. Only FIB-4 and APRI slopes influenced the same outcome. When considering NIT current value and slope simultaneously, only the current value of NITs impacted HCC risk while the slopes were not informative. Conclusions: The dynamics of NITs following SVR do not identify patients with cirrhosis who could be safely excluded from surveillance programs. NIT current value is more informative than slope, which will necessitate regularly re-assessment of HCC risk to design individualized surveillance strategies. Impact and implications: It has been postulated that monitoring non-invasive test (NIT) dynamics following HCV cure may provide information on the residual risk of hepatocellular carcinoma (HCC) in patients with cirrhosis and may allow for the discontinuation of surveillance in certain patient subsets. We analyzed data from over 3,000 patients and found that while all NITs improved in patients with cirrhosis who did not develop HCC, those who eventually developed liver cancer showed more varied changes in these tests. Specifically, the current values of tests like FIB-4 (fibrosis-4 index) and APRI (aspartate aminotransferase-to-platelet ratio index) were linked to an increased risk of HCC, while their slopes did not provide additional useful information, suggesting that dedicated prospective studies are warranted to define how repeated measurement of NITs could be combined with other variables into HCC risk stratification algorithms. Until then, HCC surveillance should be maintained in all patients with cirrhosis following HCV eradication, even in case of decreased NIT values.

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