Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 05/09/2023
• Auteurs : Yann Le GuenGuo LuoAditya AmbatiVincent DamotteIris JansenEric YuAude NicolasItziar de RojasThiago Peixoto LealAkinori MiyashitaCéline BellenguezMichelle Mulan LianKayenat ParveenTakashi MorizonoHyeonseul ParkBenjamin Grenier-BoleyTatsuhiko NaitoFahri KüçükaliSeth TalyanskySelina Maria YogeshwarVicente SempereWataru SatakeVictoria AlvarezBeatrice ArosioMichael BelloyLuisa BenussiAnne BolandBarbara BorroniMaría BullidoPaolo CaffarraJordi ClarimonAntonio DanieleDaniel DarlingStéphanie DebetteJean-François DeleuzeMartin DichgansCarole DufouilEmmanuel DuringEmrah DüzelDaniela GalimbertiGuillermo Garcia-RibasJosé María García-AlbercaPablo García-GonzálezVilmantas GiedraitisOliver GoldhardtCaroline GraffEdna GrünblattOlivier HanonLucrezia HausnerStefanie Heilmann-HeimbachHenne HolstegeJakub HortYoo Jin JungDeckert JürgenSilke KernTeemu KuulasmaaKun Ho LeeLing LinCarlo MasulloPatrizia MecocciShima MehrabianAlexandre de MendonçaMercè BoadaPablo MirSusanne MoebusFermin MorenoBenedetta NacmiasGael NicolasShumpei NiidaBørge NordestgaardGoran PapenbergJanne PapmaLucilla ParnettiFlorence PasquierPau PastorOliver PetersYolande PijnenburgGerard Piñol-RipollJulius PoppLaura Molina PorcelRaquel PuertaJordi Pérez-TurInnocenzo RaineroInez RamakersLuis RealSteffi Riedel-HellerEloy Rodriguez-RodriguezOwen RossJose Luís RoyoDan RujescuNikolaos ScarmeasPhilip ScheltensNorbert ScherbaumAnja SchneiderDavide SeripaIngmar SkoogVincenzo SolfrizziGianfranco SpallettaAlessio SquassinaJohn van SwietenRaquel Sánchez-ValleEng-King TanThomas TegosCharlotte TeunissenJesper Qvist ThomassenLucio TremolizzoMartin VyhnalekFrans VerheyMargda WaernJens WiltfangJing ZhangHenrik ZetterbergKaj BlennowZihuai HeJulie WilliamsPhilippe AmouyelFrank JessenPatrick KehoeOle AndreassenCornelia van DuinMagda TsolakiPascual Sánchez-JuanRuth Frikke-SchmidtKristel SleegersTatsushi TodaAnna ZettergrenMartin IngelssonYukinori OkadaGiacomina RossiMikko HiltunenJungsoo GimKouichi OzakiRebecca SimsJia Nee FooWiesje van der FlierTakeshi IkeuchiAlfredo RamirezIgnacio MataAgustín RuizZiv Gan-OrJean-Charles LambertMichael GreiciusEmmanuel MignotCéline BellenguezFahri KüçükaliIris JansenVictor AndradeSonia Moreno-GrauNajaf AminBenjamin Grenier-BoleyRafael Campos-MartinPeter HolmansAnne BolandLuca KleineidamVincent DamotteSven van der LeeTeemu KuulasmaaItziar de RojasAmber YaqubIvana ProkicMarcos CostaJulien ChapuisShahzad AhmadVilmantas GiedraitisDag AarslandPablo Garcia-GonzalezCarla AbdelnourEmilio Alarcón-MartínDaniel AlcoleaMontserrat AlegretIgnacio AlvarezVictoria ÁlvarezNicola ArmstrongTsolaki AnthoulaIldebrando AppollonioMarina ArcaroSilvana ArchettiAlfonso Arias PastorBeatrice ArosioLavinia AthanasiuHenri BaillyNerisa BanajMiquel BaqueroAna Belén PastorLuisa BenussiClaudine BerrCéline BesseValentina BessiGiuliano BinettiAlessandra BizarroRafael BlesaMercè BoadaBarbara BorroniSilvia BoschiPaola BossùGeir BråthenCatherine BresnerHenry BrodatyKeeley BrookesLuis Ignacio BruscoDolores Buiza-RuedaKatharina BûrgerVanessa BurholtMiguel CaleroGeneviève ChêneÁngel CarracedoRoberta CecchettiLaura Cervera-CarlesCamille CharbonnierCaterina ChillottiSimona CicconeJurgen A.H.R. ClaassenJordi ClarimonChristopher ClarkElisa ContiAnaïs Corma-GómezEmanuele CostantiniCarlo CustoderoDelphine DaianMaria Carolina DalmassoAntonio DanieleEfthimios DardiotisJean-François DartiguesPeter Paul de DeynStéphanie DebetteJürgen DeckertTeodoro del SerNicola DenningMartin DichgansJanine Diehl-SchmidMónica Diez-FairenPaolo Dionigi RossiSrdjan DjurovicEmmanuelle DuronEmrah DüzelCarole DufouilValentina Escott-PriceAna EspinosaMichael EwersMarta Fernández-FuertesCatarina FerreiraEvelyn FerriBertrand FinPeter FischerTormod FladbyKlaus FließbachJuan ForteaSilvia FostinelliNick FoxEmlio Franco-MacíasMaría BullidoAna Frank-GarcíaLutz FroelichDaniela GalimbertiJose Maria García-AlbercaPablo García-GonzálezSebastian Garcia-MadronaGuillermo Garcia-RibasRoberta GhidoniIna GieglingGiaccone GiorgioOliver GoldhardtAntonio González-PérezCaroline GraffGiulia GrandeEmma GreenTimo GrimmerEdna GrünblattTamar Guetta-BaranesAnnakaisa HaapasaloGeorgios HadjigeorgiouHarald HampelOlivier HanonJohn HardyAnnette HartmannLucrezia HausnerJanet HarwoodStefanie Heilmann-HeimbachSeppo HelisalmiMichael HenekaIsabel HernándezMartin HerrmannPer HoffmannClive HolmesHenne HolstegeRaquel Huerto VilasMarc HulsmanCharlotte JohanssonLena KilanderAnne Kinhult StåhlbomMiia KivipeltoAnne KoivistoJohannes KornhuberMary KosmidisCarmen LageErika LaukkaAlessandra LauriaJenni LehtisaloOndrej LerchAlberto LleóAdolfo Lopez de MunainMalin LöwemarkLauren LuckcuckJuan MacíasCatherine MacleodWolfgang MaierFrancesca MangialascheSpallazzi MarcoMarta MarquiéRachel MarshallAngel Martín MontesCarmen Martínez RodríguezCarlo MasulloSimon MeadPatrizia MecocciMiguel MedinaAlun MeggyShima MehrabianSilvia MendozaManuel Menéndez-GonzálezPablo MirSusanne MoebusMerel MolLaura Molina-PorcelLaura MontrrealLaura MorelliFermin MorenoKevin MorganMarkus MöthenCarolina MuchnikBenedetta NacmiasTiia NganduGael NicolasBørge NordestgaardRobert OlasoAdelina OrellanaMichela OrsiniGemma OrtegaAlessandro PadovaniCaffarra PaoloGoran PapenbergLucilla ParnettiPau PastorAlba Pérez-CordónJordi Pérez-TurPierre PericardOliver PetersYolande A.L. PijnenburgJuan PinedaGerard Piñol-RipollClaudia PisanuThomas PolakJulius PoppDanielle PosthumaJosef PrillerRaquel PuertaOlivier QuenezInés QuintelaJesper Qvist ThomassenAlberto RábanoInnocenzo RaineroInez RamakersLuis RealMarcel J.T. ReindersSteffi Riedel-HellerPeter RiedererNatalia RobertoEloy Rodriguez-RodriguezArvid RongveIrene Rosas AllendeMaitée Rosende-RocaJose Luis RoyoElisa RubinoDan RujescuMaría Eugenia SáezParaskevi SakkaIngvild SaltvedtÁngela SanabriaMaría Bernal Sánchez-ArjonaFlorentino Sanchez-GarciaPascual Sánchez JuanRaquel Sánchez-ValleSigrid SandoMichela ScamosciNikolaos ScarmeasElio ScarpiniPhilip ScheltensNorbert ScherbaumMartin SchererMatthias SchmidAnja SchneiderJonathan SchottGeir SelbækDavide SeripaAlexey ShadrinOlivia SkrobotHilkka SoininenVincenzo SolfrizziAlina SolomonSandro SorbiOscar Sotolongo-GrauGianfranco SpallettaAnnika SpottkeAlessio SquassinaEystein StordalJuan Pablo TartanLluís TárragaNiccolo TesíAnbupalam ThalamuthuTegos ThomasLatchezar TraykovLucio TremolizzoAnne Tybjærg-HansenAndre UitterlindenAbbe UllgrenIngun UlsteinSergi ValeroAad van der LugtJasper van DongenJeroen van RooijJohn van SwietenRik VandenbergheFrans VerheyJean-Sébastien VidalJonathan VogelgsangMartin VyhnalekMichael WagnerDavid WallonLeonie WeinholdJens WiltfangGill WindleBob WoodsMary YannakouliaMiren ZulaicaJan LaczoVaclav MatoskaMaria SerpenteFrancesca AssognaFabrizio PirasFederica PirasValentina CiulloJacob ShofanyCarlo FerrareseSimona AndreoniGessica SalaChiara Paola ZoiaMaria del ZompoAlberto BenussiPatrizia BastianiMari TakaloTeemu NatunenTiina LaatikainenJaakko TuomilehtoRiitta AntikainenTimo StrandbergJaana LindströmMarkku PeltonenRichard AbrahamAmmar Al-ChalabiNicholas BassCarol BrayneKristelle BrownJohn CollingeDavid CraigPangiotis DeloukasNick FoxAmy GerrishMichael GillRhian GwilliamJohn HardyDenise HaroldPaul HollingworthJarret JohnstonLesley JonesBrian LawlorGill LivingstonSimon LovestoneMichelle LuptonAoibhinn LynchDavid MannBernadette McguinnessAndrew McquillinMichael O’donovanMichael OwenPeter PassmoreJohn PowellPetra ProitsiMartin RossorChristopher ShawA. David SmithHugh GurlingStephen ToddCatherine MummeryNathalie RyanGiordano LacidognaAd Adarmes-GómezAna MauleónAna PanchoAnna GailhajenetAsunción LafuenteD Macias-GarcíaElvira MartínEsther PelejàF CarrilloIsabel Sastre MerlínL Garrote-EspinaLiliana VargasM Carrion-ClaroM MarínMa LabradorMar BuendiaMaría Dolores AlonsoMarina GuitartMariona MorenoMarta IbarriaMt PeriñánNuria AguileraP Gómez-GarrePilar CañabateR EscuelaR Pineda-SánchezR Vigo-OrtegaS JesúsSilvia PrecklerSilvia Rodrigo-HerreroSusana DiegoAlessandro VaccaFausto RovetaNicola SalvadoriElena ChipiHenning BoeckerChristoph LaskeRobert PerneczkyCostas AnastasiouDaniel JanowitzRainer MalikAnna AnastasiouKayenat ParveenCarmen LageSara López-GarcíaAnna AntonellKalina Yonkova MihovaDiyana BelezhanskaHeike WeberSilvia KochenPatricia SolisNancy MedelJulieta LissoZulma SevillanoDaniel PolitisValeria CoresCarolina CuestaCecilia OrtizJuan Ignacio BachaMario RiosAldo SaenzMariana Sanchez AbalosEduardo KohlerDana Lis PalacioIgnacio EtcheparebordaMatias KohlerGisela NovackFederico Ariel PrestiaPablo GaleanoEduardo CastañoSandra GermaniCarlos Reyes TosoMatias RojoCarlos InginoCarlos MangoneSebastiaan EngelborghsTagliavini FabrizioSune Fallgaard NielsenLucia FarottiChiara FenoglioGeert Jan BiesselsSeth LovePatrick KehoeChristine van BroeckhovenDavid RubinszteinStefan TeipelNathalie FievetVincent DeramecourtCharlotte ForsellHåkan ThonbergMaria BjerkeEllen de RoeckMaría Teresa Martínez-LarradNatividad OlivarMohsen GhanbariPerminder SachdevKaren MatherFrank JessenM. Arfan IkramAlexandre de MendonçaJakub HortTsolaki MagdaPhilippe AmouyelJulie WilliamsRuth Frikke-SchmidtJordi ClarimonJean-François DeleuzeGiacomina RossiOle AndreassenMartin IngelssonMikko HiltunenKristel SleegersCornelia van DuijnRebecca SimsWiesje van der FlierAgustín RuizAlfredo RamirezJean-Charles LambertN AguileraE AlarconM AlegretM BoadaM BuendiaA CanoP CañabateA CarracedoA Corbatón-AnchueloI de RojasS DiegoA EspinosaA GailhajenetP García-GonzálezM GuitartA González-PéerezM IbarriaA LafuenteJ MaciasO MaroñasE MartínMt MartínezM MarquiéL MontrrealS Moreno-GrauM MorenoR. Nuñez-LlavesC OlivéA OrellanaG OrtegaA PanchoE PelejàA Pérez-CordonJa PinedaR PuertaS PrecklerI QuintelaLm RealM Rosende-RocaA RuizMe SáezA SanabriaM Serrano-RiosO Sotolongo-GrauL TáarragaS ValeroL VargasAd Adarmes-GómezE Alarcón-MartínMd AlonsoI ÁlvarezV ÁlvarezG Amer-FerrerM AntequeraC AntúnezM BaqueroM BernalR BlesaM BoadaD Buiza-RuedaMj BullidoJa BurgueraM CaleroF CarrilloM Carrión-ClaroMj CasajerosJ ClarimónJm Cruz-GameroMm de PancorboI de RojasT del SerM Diez-FairenR EscuelaL Garrote-EspinaJ ForteaE FrancoA Frank-GarcíaJm García-AlbercaS Garcia MadronaG Garcia-RibasP Gómez-GarreS HevillaS JesúsMa Labrador EspinosaC LageA LegazA LleóoA Lóopez de MunáinS López-GarcíaD Macias-GarcíaS ManzanaresM MarínJ Marín-MuñozT MarínM MarquiéA Martín MontesB MartínezC MartínezV MartínezA Martínez-Lage ÁlvarezM MedinaM Mendioroz IriarteM Menéndez-GonzálezP MirL MontrrealA OrellanaP PastorJ Péerez TurT Periñán-TocinoR Pineda-SánchezG Piñol RipollA RáabanoD Real de AsúaS RodrigoE Rodríguez-RodríguezJl RoyoA RuizR Sanchez del Valle DíazP Sánchez-JuanI SastreO Sotolongo-GrauS ValeroMp VicenteR Vigo-OrtegaL VivancosAlexey ShadrinShahram BahramiArvid RongveGeir BråthenIngunn BosnesEystein StordalLavinia AthanasiuPer SelnesIngvild SaltvedtSigrid SandoSverre BerghIngun UlsteinSrdjan DjurovicTormod FladbyDag AarslandGeir SelbækOle AndreassenCéline BellenguezBenjamin Grenier-BoleyJacques EpelbaumDavid WallonDidier HannequinClaudine BerrDominique CampionChristophe TzourioVincent DermecourtNathalie FievetOlivier HanonCarole DufouilAlexis BriceBruno DuboisKaren RitchiePhillippe AmouyelJean-Charles LambertDenise HaroldPaul HollingworthRebecca SimsAmy GerrishNicola DenningAmy WilliamsCharlene ThomasAlun MeggyRachel MarshallChloe DaviesLauren LuckcuckWilliam NashKimberley DowzellAtahualpa Castillo MoralesMateus Bernardo-HarringtonPatrick KehoePer HoffmannSeth LoveJames TurtonJenny LordKristelle BrownKevin MorganEmma VardyElizabeth FisherJason WarrenJonathan SchottMartin RossorNatalie RyanNick FoxRita GuerreiroSimon MeadJames UphillJohn CollingeMichelle LuptonAmmar Al-ChalabiChristopher ShawNick BassRichard AbrahamReinhard HeunHeike KölschBritta SchürmannFrank JessenWolfgang MaierNdré LacourChristine HeroldSimon LovestoneBernadette McguinnessDavid CraigJanet JohnstonMichael GillPeter PassmoreStephen ToddJohn PowellPetra ProitsiYogen PatelAngela HodgesTim BeckerA. David SmithDonald WardenGordon WilcockRobert ClarkeAoibhinn LynchBrian LawlorMichael GillAndrew McquillinGill LivingstonJohn HardyDavid RubinszteinCarol BrayneRhian GwilliamPanagiotis DeloukasYoav Ben-ShlomoDavid MannNigel HooperStuart Pickering-BrownClive HolmesRebecca SussamsNick WarnerAnthony BayerAndrew SingletonAnnette HartmannDan RujescuIna GieglingHarald HampelMartin DichgansIsabella HeuserDmitriy DrichelNorman KloppMarkus NöthenManuel MayhausMatthias RiemenschneiderSabrina PinchlerThomas FeulnerWei GuHendrik den BusscheMartin SchererJens WiltfangJohannes KornhuberMichael HüllLutz FrölichH-Erich WichmannKarl-Heinz JöckelSusanne MoebusSteffi Riedel-HellerJohn KauweJohn MorrisKevin MayoMagda TsolakiMichael O’donovanLesley JonesMichael OwenValentina Escott-PriceAlfredo RamirezPeter HolmansJulie WilliamsJia Nee FooElaine Guo Yan ChewSun Ju ChungRong PengYinxia ChaoLouis Cs TanMoses TandionoMichelle LianEbonne NgKumar-M. PrakashWing-Lok AuWee-Yang MeahShi Qi MokAzlina Ahmad AnnuarAnne Yy ChanLing ChenYongping ChenBeom JeonLulu JiangJia Lun LimJuei-Jueng LinChunfeng LiuChengjie MaoVincent MokZhong PeiHui-Fang ShangChang-He ShiKyuyoung SongAi Huey TanYih-Ru WuYu-Ming XuRenshi XuYaping YanJing YangBao Rong ZhangWoon-Puay KohShen-Yang LimChiea Chuen KhorJianjun LiuEng-King Tan
• Organismes : Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
• Publié dans Proceedings of the National Academy of Sciences of the United States of America le 31/10/2020

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Résumé : Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1 *04 subtypes best accounted for the association, strongest with HLA-DRB1 *04:04 and HLA-DRB1 *04:07, and intermediary with HLA-DRB1 *04:01 and HLA-DRB1 *04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1 *04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1 *04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues.

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Fichiers liés : 2023%20PNAS%20120-e2302720120.pdf

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• Type de publi. : Communication dans un congrès
• Date de publi. : 04/09/2023
• Auteurs : Philippe Andrey
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal

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• Type de publi. : Article dans une revue
• Date de publi. : 04/09/2023
• Auteurs : Pierre NivoitThomas MathivetJunxi WuYann SalemkourDevanarayanan Siva SankarVéronique BaudrieJennifer BourreauAnne-Laure GuihotEmilie VessieresMathilde LemitreCinzia BoccaJérémie TeillonMorgane Le GallAnna ChipontEstelle RobidelNeeraj DhaunEric CamererPascal ReynierEtienne RouxThierry CouffinhalPatrick W F HadokeJean-Sébastien SilvestreXavier GuillonneauPhilippe BonninDaniel HenrionJoern DengjelPierre-Louis TharauxOlivia Lenoir
• Organismes : Bordeaux Imaging Center Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
• Publié dans Cellular and Molecular Life Sciences le 29/10/2020

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Résumé : Correction: Cellular and Molecular Life Sciences (2023) 80:210 https://doi.org/10.1007/s00018-023-04859-9

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Fichiers liés : BMC_CellMolLifeSci_2023_Nivoit.pdf

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• Type de publi. :
• Date de publi. : 04/09/2023
• Auteurs : Alexandre DurrmeyerJean-Christophe PalauquiPhilippe Andrey
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay AgroParisTech Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay AgroParisTech Institut Jean-Pierre Bourgin - Sciences du végétal Université Paris-Saclay AgroParisTech

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Résumé : Plant embryo development is an intricate process whereby a complex organism arises from a single cell. At the cellular scale, this process hinges on the fundamental mechanisms of cell division and growth. Cell division, in particular, plays a pivotal role by reshaping tissue properties like mechanical constraints and topology, thereby influencing morphology. Predicting the positioning of a new cell wall during division is thus crucial for understanding morphogenesis. Early attempts to predict cell division positioning relied on geometric approaches based on the shape of the mother cell. While geometry contributes to division plane positioning, other factors like chemical signaling, mechanical constraints, and tissue-scale optimizations also exert influence. However, deciphering how each factor impacts division remains challenging. Current models, whether based on geometry, stresses, or other properties, are typically rule-based, incorporating manually defined rules that may contain human biases or overlook certain aspects. It is then difficult to define whether the data does not fit any rule or if the right rule was simply not identified. In A. thaliana embryos, a geometric division rule successfully fit the observed divisions from stage 1C to stage 32C, with the exception of the stage 16C basal intern cells (Moukhtar et al. 2019, Laruelle et al. 2022). Do these latter cells follow a different rule from the previous stages, or is there an alternative common rule? To ensure that the proposed division rule aligns as closely as possible with observations, we propose a method to automatically learn predicting cell division plane positioning in a supervised framework. Leveraging U-Net3D, a deep learning architecture tailored for biological image segmentation, we train a model to approximate division rules based on an image dataset of before/after division pairs. This formulation transforms the prediction of division plane positioning into a more accessible segmentation task. Additionally, representing mother cells by their 3D image masks enables the model to approximate a strict geometric division rule from fully preserved geometric information. We conducted multiple experiments to assess the potential and limitations of this novel approach. We first evaluated the network's ability to learn a simple division rule using synthetic shapes like cuboids and ellipsoids. Subsequently, we tested the model's generalization capability across different shapes and its performance in approximating complex division rules. Finally, we applied the approach to real A. thaliana embryo cells spanning developmental stages 1C to 32C. We trained the model to learn stage-specific division rules and subsequently a universal rule applicable across all stages.

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Fichiers liés : Poster.pdf

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• Type de publi. :
• Date de publi. : 03/09/2023
• Auteurs : Annia Alba MenéndezR. ScholsAntonio VazquezJ. SánchezPhilippe DouchetM. SanchezD. FaugèreJean-Pierre PointierSylvie Hurtrez-BoussèsT. HuyseOlivier ReyBenjamin Gourbal
• Organismes : Pedro Kouri Institute of Tropical Medicine Interactions Hôtes-Pathogènes-Environnements Interactions Hôtes-Pathogènes-Environnements Interactions Hôtes-Pathogènes-Environnements CISDEM-CSIC Centre de recherches insulaires et observatoire de l'environnement Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle Interactions Hôtes-Pathogènes-Environnements Interactions Hôtes-Pathogènes-Environnements

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• Type de publi. : Article dans une revue
• Date de publi. : 02/09/2023
• Auteurs : Julien VaidieEdwige PejuLouise-Marie JandeauxMathieu LesouhaitierJean-Claude LacheradeAntoine GuillonXavier WittebolePierre AsfarBruno EvrardThomas DaixPhilippe VignonBruno François
• Organismes : Service de Réanimation Polyvalente [CHU Limoges] Hôpital Cochin [AP-HP] Nouvel Hôpital Civil de Strasbourg Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre d’Etude des Pathologies Respiratoires [Tours] Université de Tours Centre Hospitalier Régional Universitaire de Tours Cliniques universitaires St Luc [Bruxelles] Centre Hospitalier Universitaire d'Angers Centre d'Investigation Clinique de Limoges Centre Hospitalier Universitaire Dupuytren 1 et 2 Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Centre d'Investigation Clinique de Limoges Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Centre Hospitalier Universitaire Dupuytren 1 et 2 Centre d'Investigation Clinique de Limoges Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Centre Hospitalier Universitaire Dupuytren 1 et 2
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Except in a few retrospective studies mainly including patients under chemotherapy, information regarding the impact of immunosuppressive therapy on the prognosis of patients admitted to the intensive care unit (ICU) for septic shock is scarce. Accordingly, the PACIFIC study aimed to asses if immunosuppressive therapy is associated with an increased mortality in patients admitted to the ICU for septic shock. Methods This was a retrospective epidemiological multicentre study. Eight high enroller centres in septic shock randomised controlled trials (RCTs) participated in the study. Patients in the “exposed” group were selected from the screen failure logs of seven recent RCTs and excluded because of immunosuppressive treatment. The “non-exposed” patients were those included in the placebo arm of the same RCTs. A multivariate logistic regression model was used to estimate the risk of death. Results Among the 433 patients enrolled, 103 were included in the “exposed” group and 330 in the “non-exposed” group. Reason for immunosuppressive therapy included organ transplantation (n = 45 [44%]) or systemic disease (n = 58 [56%]). ICU mortality rate was 24% in the “exposed” group and 25% in the “non-exposed” group ( p = 0.9). Neither in univariate nor in multivariate analysis immunosuppressive therapy was associated with a higher ICU mortality (OR: 0.95; [95% CI 0.56–1.58]: p = 0.86 and 1.13 [95% CI 0.61–2.05]: p = 0.69, respectively) or 3-month mortality (OR: 1.13; [95% CI 0.69–1.82]: p = 0.62 and OR: 1.36 [95% CI 0.78–2.37]: p = 0.28, respectively). Conclusions In this study, long-term immunosuppressive therapy excluding chemotherapy was not associated with significantly higher or lower ICU and 3-month mortality in patients admitted to the ICU for septic shock.

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Fichiers liés : s13054-023-04626-z.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2023
• Auteurs : Alexia BodinLogan GreibillJulien GoujuFranck LetournelSilvia PozziJean-Pierre JulienLaurence RenaudDelphine BohlStéphanie MillecampsChristophe VernyJulien CassereauGuy LenaersArnaud ChevrollierAnne-Marie TassinPhilippe Codron
• Organismes : MitoVasc - Équipe MitoLab (Mitochondrial Pathophysiology) Institut de Biologie Intégrative de la Cellule Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers Département de Psychiatrie et Neurosciences [Université Laval] = Department of Psychiatry and Neuroscience [University of Laval] Centre de recherche de l’Institut universitaire en santé mentale de Québec [Canada] Département de Psychiatrie et Neurosciences [Université Laval] = Department of Psychiatry and Neuroscience [University of Laval] Centre de recherche de l’Institut universitaire en santé mentale de Québec [Canada] Département de Psychiatrie et Neurosciences [Université Laval] = Department of Psychiatry and Neuroscience [University of Laval] Groupe de recherche sur le système nerveux central [Montréal] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute Centre Hospitalier Universitaire d'Angers MitoVasc - Équipe MitoLab (Mitochondrial Pathophysiology) Centre Hospitalier Universitaire d'Angers MitoVasc - Équipe MitoLab (Mitochondrial Pathophysiology) MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire d'Angers MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Institut de Biologie Intégrative de la Cellule MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale Centre Hospitalier Universitaire d'Angers Centre Hospitalier Universitaire d'Angers
• Publié dans Brain - A Journal of Neurology le 29/10/2020

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Résumé : Abstract The centrosome, as the main microtubule organizing centre, plays key roles in cell polarity, genome stability and ciliogenesis. The recent identification of ribosomes, RNA-binding proteins and transcripts at the centrosome suggests local protein synthesis. In this context, we hypothesized that TDP-43, a highly conserved RNA binding protein involved in the pathophysiology of amyotrophic lateral sclerosis and frontotemporal lobar degeneration, could be enriched at this organelle. Using dedicated high magnification sub-diffraction microscopy on human cells, we discovered a novel localization of TDP-43 at the centrosome during all phases of the cell cycle. These results were confirmed on purified centrosomes by western blot and immunofluorescence microscopy. In addition, the co-localization of TDP-43 and pericentrin suggested a pericentriolar enrichment of the protein, leading us to hypothesize that TDP-43 might interact with local mRNAs and proteins. Supporting this hypothesis, we found four conserved centrosomal mRNAs and 16 centrosomal proteins identified as direct TDP-43 interactors. More strikingly, all the 16 proteins are implicated in the pathophysiology of TDP-43 proteinopathies, suggesting that TDP-43 dysfunction in this organelle contributes to neurodegeneration. This first description of TDP-43 centrosomal enrichment paves the way for a more comprehensive understanding of TDP-43 physiology and pathology.

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/09/2023
• Auteurs : Muriel GandelinPhilippe GouézinIvy Thomson
• Organismes : Institut national de recherches archéologiques préventives Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés Centre de Recherche en Archéologie, Archéosciences, Histoire Institut national de recherches archéologiques préventives

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• Type de publi. : Article dans une revue
• Date de publi. : 01/09/2023
• Auteurs : Amedeo AnselmiAlexandre MansourMarylou ParaNicolas MongardonAlizée PortoJulien GuihaireMarie-Catherine MorgantMatteo PozziBernard CholleyPierre Emmanuel FalcozPhilippe GaudardGuillaume LebretonFrançois LabasteClaudio BarbantiOlivier FouquetSidney ChocronNicolas MottardMaxime EsvanClaire Fougerou-LeurentErwan FlecherAndré VincentelliNicolas NesselerMarc PierrotGuillaume FlicoteauxPhilippe MauriatAlexandre OuattaraHadrien RozeOlivier HuetMarc-Olivier FischerClaire AlessandriRaphel BellaïcheOphélie ConstantQuentin de RouxAndré LyArnaud MeffertJean-Claude MerleLucile PicardElena SkripkinaThierry FolliguetAntonio FioreNicolas D’ostrevyMarie-Catherine MorganPierre-Grégoire GuinotMaxime NguyenLucie Gaide-ChevronnayNicolas TerziGwenhaël ColinOlivier FabreArash AstanehJustin IssardElie FadelDominique FabreAntoine GiraultIolande IonJean Baptiste MenagerDelphine MitilianOlaf MercierFrançois StephanJacques ThesJerôme JouanThibault DuburcqValentin LoobuyckMouhammed MoussaAgnes MugnierNatacha RousseSabrina ManganielloOlivier DesebbeJean-Luc FellahiRoland HénaineMatteo PozziJean-Christophe RichardZakaria RiadChristophe GuervillyMuriel FartoukhLaurent PapazianMatthias CastanierCharles ChanavazCyril CadozSebastien GetteGuillaume LouisErick PortocarreroKais BriniNicolas BischoffBruno LevyAntoine KimmounMathieu MatteiPierre PerezAlexandre BourdiolYannick HourmantPierre-Joachim MahéBertrand RozecMickaël Vourc'HStéphane AubertFlorian BazalgetteClaire Penetrat-RogerPierre JaquetBrice Lortat-JacobPierre MordantPatrick NatafJuliette PatrierSophie ProvenchereMorgan RouéRomain SonnevilleAlexy Tran-DinhPaul-Henri WickyCharles Al ZreibiYannis GuyonvarchSophie HamadaAstrid BertierAnatole HarroisJordi MatielloT KerforneCorentin LacroixNicolas BrechotAlain CombesMatthieu SchmidtJuliette ChommelouxJean Michel ConstantinCosimo d'AlessandroPierre DemondionAlexandre DemouleMartin DresGuillaume FadelMuriel FartoukhGuillaume HekimianCharles JuvinPascal LeprinceDavid LevyCharles Edouard LuytMarc Pineton de ChambrunThibaut SchoellPierre FillâtreNicolas MassartRoxane NicolasMaud JonasCharles VidalNicolas AllouSalvatore MuccioDario Di PernaVito-Giovanni RuggieriBruno MourvillierKarl BounaderYoann LauneyThomas LebouvierAlessandro ParasidoFlorian ReizinePhilippe SeguinEmmanuel BesnierDorothée CarpentierThomas ClavierAnne OllandMarion VillardFanny BounesVincent MinvilleAntoine GuillonYannick FedunJames Ross
• Organismes : Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire de Recherche Vasculaire Translationnelle After ROSC research network [Paris, France] Hôpital Henri Mondor Département de Chirurgie Cardique Timone Assistance Publique - Hôpitaux de Marseille Hypertension pulmonaire : physiopathologie et innovation thérapeutique Service de chirurgie cardio-vasculaire et thoracique (CHU Dijon) Hôpital Louis Pradel [CHU - HCL] Hôpital Européen Georges Pompidou [APHP] Innovations thérapeutiques en hémostase = Innovative Therapies in Haemostasis Service de Chirurgie Thoracique Nanomédecine Régénérative Faculté de médecine, maïeutique et sciences de la santé [Strasbourg] Fédération de Médecine Translationnelle de Strasbourg Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] CHU Pitié-Salpêtrière [AP-HP] Pôle Anesthésie Réanimation [CHU de Toulouse] Hôpital Necker - Enfants Malades [AP-HP] Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( UR 3920) Centre Hospitalier Lyon Sud [CHU - HCL] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut Coeur Poumon [CHU Lille]
• Publié dans European Journal of Cardio-Thoracic Surgery le 22/10/2020

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Résumé : OBJECTIVES The clinical profile and outcomes of patients with Coronavirus Disease 2019 (COVID-19) who require veno-arterial extracorporeal membrane oxygenation (VA-ECMO) or veno-arterial-venous extracorporeal membrane oxygenation (VAV-ECMO) are poorly understood. We aimed to describe the characteristics and outcomes of these patients and to identify predictors of both favourable and unfavourable outcomes. METHODS ECMOSARS is a multicentre, prospective, nationwide French registry enrolling patients who require veno-venous extracorporeal membrane oxygenation (ECMO)/VA-ECMO in the context of COVID-19 infection (652 patients at 41 centres). We focused on 47 patients supported with VA- or VAV-ECMO for refractory cardiogenic shock. RESULTS The median age was 49. Fourteen percent of patients had a prior diagnosis of heart failure. The most common aetiologies of cardiogenic shock were acute pulmonary embolism (30%), myocarditis (28%) and acute coronary syndrome (4%). Extracorporeal cardiopulmonary resuscitation (E-CPR) occurred in 38%. In-hospital survival was 28% in the whole cohort, and 43% when E-CPR patients were excluded. ECMO cannulation was associated with significant improvements in pH and FiO2 on day 1, but non-survivors showed significantly more severe acidosis and higher FiO2 than survivors at this point (P = 0.030 and P = 0.006). Other factors associated with death were greater age (P = 0.02), higher body mass index (P = 0.03), E-CPR (P = 0.001), non-myocarditis aetiology (P = 0.02), higher serum lactates (P = 0.004), epinephrine (but not noradrenaline) use before initiation of ECMO (P = 0.003), haemorrhagic complications (P = 0.001), greater transfusion requirements (P = 0.001) and more severe Survival after Veno-Arterial ECMO (SAVE) and Sonographic Assessment of Intravascular Fluid Estimate (SAFE) scores (P = 0.01 and P = 0.03). CONCLUSIONS We report the largest focused analysis of VA- and VAV-ECMO recipients in COVID-19. Although relatively rare, the need for temporary mechanical circulatory support in these patients is associated with poor prognosis. However, VA-ECMO remains a viable solution to rescue carefully selected patients. We identified factors associated with poor prognosis and suggest that E-CPR is not a reasonable indication for VA-ECMO in this population.

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• Type de publi. :
• Date de publi. : 01/09/2023
• Auteurs : Bru PPhilippe PointereauChavre ATondusson JIsabelle LegrandJean-François HocquetteMarie-Pierre Ellies-Oury
• Organismes : Unité Mixte de Recherche sur les Herbivores - UMR 1213 Unité Mixte de Recherche sur les Herbivores - UMR 1213 Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine

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