Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Elodie DarboGaëlle PérotLucie DarmuseySophie Le GuellecLaura LeroyLaëtitia GastonNelly DesplatNoémie ThébaultCandice MerlePhilippe RochaixThibaud ValentinGwenaël FerronChristine ChevreauBinh BuiEberhard StoeckleDominique Ranchere-VincePierre MéeusPhilippe TerrierSophie Piperno-NeumannFrançoise CollinGonzague de PinieuxFlorence DuffaudJean-Michel CoindreJean-Yves BlayFrédéric Chibon
• Organismes : Institut Bergonié [Bordeaux] Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Institut Bergonié [Bordeaux] Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Centre de Recherches en Cancérologie de Toulouse Institut Bergonié [Bordeaux] Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre de Recherches en Cancérologie de Toulouse
• Publié dans Cancers le 21/10/2020

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Résumé : In leiomyosarcoma (LMS), a very aggressive disease, a relatively transcriptionally uniform subgroup of well-differentiated tumors has been described and is associated with poor survival. The question raised how differentiation and tumor progression, two apparently antagonist processes, coexist and allow tumor malignancy. We first identified the most transcriptionally homogeneous LMS subgroup in three independent cohorts, which we named ‘hLMS’. The integration of multi-omics data and functional analysis suggests that hLMS originate from vascular smooth muscle cells and show that hLMS transcriptional program reflects both modulations of smooth muscle contraction activity controlled by MYOCD/SRF regulatory network and activation of the cell cycle activity controlled by E2F/RB1 pathway. We propose that the phenotypic plasticity of vascular smooth muscle cells coupled with MYOCD/SRF pathway amplification, essential for hLMS survival, concomitant with PTEN absence and RB1 alteration, could explain how hLMS balance this uncommon interplay between differentiation and aggressiveness.

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : C. DariePierre BordetMélanie ViaudCatherine Guillot-DeudonPhilippe DeniardÉric GautronClaire V. ColinFlorence PorcherGuido BerlandaFabrice BertPhilippe MendelsChristophe Payen
• Organismes : Matériaux, Rayonnements, Structure Matériaux, Rayonnements, Structure Institut des Matériaux de Nantes Jean Rouxel Institut des Matériaux de Nantes Jean Rouxel Institut des Matériaux de Nantes Jean Rouxel Institut des Matériaux de Nantes Jean Rouxel Matériaux, Rayonnements, Structure Laboratoire Léon Brillouin Laboratoire de Physique des Solides Laboratoire de Physique des Solides - SQM Laboratoire de Physique des Solides Institut des Matériaux de Nantes Jean Rouxel
• Publié dans Journal of Solid State Chemistry le 26/10/2020

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Résumé : Two new cubic perovskite oxides Ba3CoSb2O9 and Ba2SrCoSb2O9 were prepared and characterized. Ba3CoSb2O9 was prepared in polycrystalline form by high-pressure (HP) high-temperature treatment of the hexagonal 6H polytype of Ba3CoSb2O9. Polycrystalline samples of Ba2SrCoSb2O9 were obtained at ambient pressure by a solidstate reaction method. Combined Rietveld refinements of X-ray and neutron diffraction patterns indicated that HP Ba3CoSb2O9 and Ba2SrCoSb2O9 both crystallize in a Fm (3) over barm cubic double perovskite A(2)BB'O-6 structure with formulae Ba-2(Sb0.83Co0.17)(Co0.5Sb0.5)O-6 and (Ba1.33Sr0.67)Sb(Co0.7Sb0.3)O-6, respectively. Electron diffraction results obtained for Ba2SrCoSb2O9 showed no sign of additional periodicity. Weiss temperatures extracted from high-temperature magnetic susceptibility data were. theta approximate to -113 K and -118 K for HP Ba3CoSb2O9 and Ba2SrCoSb2O9, respectively. HP Ba3CoSb2O9 displays a weak ZFC-FC magnetic irreversibilty below 8 K. Ba2SrCoSb2O9 exhibits a spin freezing at T-f approximate to 6 K, and mu SR and Sb-121 NMR data revealed a magnetic transition towards a disordered ground state.

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Fichiers liés : JSSC-22-2145-REV.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/01/2023
• Auteurs : Nicolas SuberbielleJean AlesandriJean-Michel BellangerThierry FenouilDidier BorgarinoPierre-Arthur MoreauPhilippe AubelMarie-Rose d'AngeloJoseph Puccini
• Organismes : Centre d’Ecologie Fonctionnelle et Evolutive Institut National de la Santé et de la Recherche Médicale Laboratoire de Génie Civil et Géo-Environnement (LGCgE) - ULR 4515

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Résumé : En raison d’une exploitation intensive du sapin par le passé, les sapinières pures sont rares en Corse. Les inventaires réalisés dans cinq d’entre elles (Caralba, Marmano, Puntaniella, Samulaghja et Ovace) nous ont permis d’étudier le cortège fongique, jusque-là méconnu, de ce milieu particulier. Plus de 370 taxons ont été observés, dont 88 sont inédits pour la Corse. Un grand nombre d’espèces caractéristiques des vieilles forêts ont également été découvertes mettant en évidence leur richesse exceptionnelle et la nécessité de préserver la continuité écologique de ces écosystèmes.

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Fichiers liés : Suberbielle 2023 CBNC.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Lucas GuilloBenoit FlachaireJérôme AvouacCatherine DongMaria NachuryGuillaume BouguenAnthony BuissonLudovic CailloMathurin FumeryCyrielle GillettaXavier HébuternePierre LafforgueDavid LaharieEmmanuel MahéHubert MarotteStéphane NanceySébastien OttavianiJean-Hugues SalmonGuillaume SavoyeMélanie SerreroMathieu UzzanManuelle ViguierChristophe RichezLaurent Peyrin‐BirouletPhilipe SeksikThao PhamPhilippe Ah-SouneNadia ArabLaurent BeaugerieLoïs BolkoJoelle BonnetYoram BouhnikAnne BourrierFranck BrazierFranck CarbonnelMaeva CharkaouiIsabelle Charlot-LambrechtAntoine ChupinAlice CombierMarion CoudercFabienne CouryAriadne DesjeuxNicolas DuveauAnne GraslandJean-Charles GrimaudXavier GuennocCécilia LandmanIsabelle Nion-LarmurierCatherien LeberreRomain LeenhardtAude Le GofficHenri MontaudieJacques MorelThierry PasseronJeanne-Marie Perotin CollardElodie PoisnelVincent PradelMartin SoubrierHarry SokolEric ToussirotCaroline TrangMy-Linh Trans MinhSophie TrijauFrank VerhoevenStéphanie ViennotDaniel Wendling
• Organismes : Hôpital Nord [CHU - APHM] Assistance Publique - Hôpitaux de Marseille Hôpital Nord [CHU - APHM] Assistance Publique - Hôpitaux de Marseille Service de rhumatologie [CHU Cochin] Service d'Hépato-gastro-entérologie [APHP Kremlin-Bicêtre] Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Nutrition, Métabolismes et Cancer Infection Inflammation et Interaction Hôtes Pathogènes [CHU Clermont-Ferrand] Centre Hospitalier Universitaire de Nîmes CHU Amiens-Picardie Périnatalité et Risques Toxiques - UMR INERIS_I 1 UPJV Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Nice Hôpital Nord [CHU - APHM] Assistance Publique - Hôpitaux de Marseille Hôpital Haut-Lévêque [CHU Bordeaux] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Biologie Intégrative du Tissu Osseux Centre International de Recherche en Infectiologie AP-HP - Hôpital Bichat - Claude Bernard [Paris] Vieillissement, Fragilité Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau Institute for Research and Innovation in Biomedicine Université de Rouen Normandie Service d'Hépato-Gastroentérologie [CHU Rouen] Hôpital Nord [CHU - APHM] Service de Gastroentérologie [Hôpital Beaujon] Hôpital universitaire Robert Debré [Reims] Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle Nutrition-Génétique et Exposition aux Risques Environnementaux Service d'Hépato-gastro-entérologie [CHRU Nancy] Centre de Recherche Saint-Antoine Hôpital Nord [CHU - APHM] Assistance Publique - Hôpitaux de Marseille CHU Amiens-Picardie
• Publié dans Digestive and Liver Disease le 01/11/2020

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Résumé : BACKGROUND: Use of a combination of targeted therapies (COMBIO) in patients with refractory/overlapping immune-mediated inflammatory diseases (IMIDs) has increased, but reported data remain scarce. We aimed to assess effectiveness and safety of COMBIO in patients with IMIDs. METHODS: We conducted a French ambispective multicenter cohort study from September 2020 to May 2021, including adults' patients with 1 or 2 IMIDs and treated at least 3-month with COMBIO. RESULTS: Overall, 143 patients were included. The most common IMIDs were Crohn's disease (63.6%), axial spondyloarthritis (37.7%), and ulcerative colitis (14%). Half of patients had only one IMID, of which 60% were Crohn's disease. Mean duration of COMBIO was 274.5±59.3 weeks, and COMBIO persistence at 104 weeks was estimated at 64.1%. The most frequent COMBIOs combined anti-TNF agents with vedolizumab (30%) or ustekinumab (28.7%). Overall, 50% of patients achieved significant and 27% mild-to-moderate improvement in patient-reported outcomes. Extended duration of COMBIO (aOR=1.09; 95% CI: 1.03-1.14; p=0.002) and diagnoses of two IMIDs (aOR=3.46; 95%CI: 1.29-9.26; p=0.013) were associated with significant improvement in patient-reported outcomes. Incidence of serious infection during COMBIO was 4.51 per 100 person-years (95% CI 2.20-8.27) and 5 COMBIOs were discontinued due to adverse events. CONCLUSIONS: COMBIO can be effective and safe in patients with refractory/overlapping IMIDs.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Audrey de JongAnne BignonFrançois StéphanThomas GodetJean-Michel ConstantinKarim AsehnouneAude SylvestreJuliette SautilletRaiko BlondonnetMartine FerrandierePhilippe SeguinSigismond LasockiAmélie RolléPierre-Marie FayolleLaurent MullerEmmanuel PardoNicolas TerziSeverin RaminBoris JungPaër-Sélim AbbackPhilippe GuerciBenjamine SartonHadrien RozéClaire DupuisJoel CoussonMarion FaucherVirginie LemialeBernard CholleyGerald ChanquesFouad BelafiaHelena HuguetEmmanuel FutierÉlie AzoulayNicolas MolinariSamir JaberRoman CalypsoAstrid Bouteau-DurandMichel CarlesHossen MehdaouiBertrand SouweineLaure CalvetMatthieu JabaudonBenjamin RieuClara CandilleFlorian SigaudBeatrice RiuLaurent PapazianSabine ValeraDjamel MokartLaurent Chow ChineMagali BisbalCamille PouliquenJean-Manuel de GuibertMaxime TourretDamien MalletMarc LeoneLaurent ZieleskiewiczJeanne CossicMona AssefiElodie BaronCyril QuemeneurAntoine MonselMatthieu BiaisAlexandre OuattaraEline BonnardelSimon MonziolsMartin MahulJean-Yves LefrantClaire RogerSaber BarbarFabien LambiottePiehr Saint-LegerCatherine PaugamJulien PottecherPierre-Olivier LudesLucie DarrivereMarc GarnierEric KipnisGilles LebuffeMatthias GarotJeremy FalconeBenjamin ChoustermanMagali ColletEtienne GayatJean DellamonicaWilly-Serge MfamEvelina OchinMohamed NebliNejla TiloucheBenjamin MadeuxDavid BougonYassir AarabFanny Garnier
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [CHU Lille] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Hôpital Marie-Lannelongue CHU Clermont-Ferrand CHU Pitié-Salpêtrière [AP-HP] Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre d'études et de recherche sur les services de santé et la qualité de vie Hôpital Nord [CHU - APHM] Centre Hospitalier de la Polynésie Française CHU Clermont-Ferrand Centre Hospitalier Régional Universitaire de Tours Université de Tours Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Nutrition, Métabolismes et Cancer Centre Hospitalier Universitaire d'Angers Université d'Angers CHU Pointe-à-Pitre / Abymes [Guadeloupe] Centre Hospitalier Universitaire de Martinique [Fort-de-France, Martinique] Centre Hospitalier Universitaire de Nîmes Groupe de Recherche Clinique en Anesthésie Réanimation médecine PEriopératoire CHU Saint-Antoine [AP-HP] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Beaujon [AP-HP] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Toulouse Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Centre Hospitalier Universitaire de Bordeaux CHU Clermont-Ferrand Hôpital universitaire Robert Debré [Reims] Institut Paoli-Calmettes Hopital Saint-Louis [AP-HP] Hôpital Européen Georges Pompidou [APHP] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Institut Montpelliérain Alexander Grothendieck Centre Hospitalier Régional Universitaire [Montpellier] CHU Clermont-Ferrand Hopital Saint-Louis [AP-HP] Institut Desbrest d'Epidémiologie et de Santé Publique Médecine de précision par intégration de données et inférence causale Institut Montpelliérain Alexander Grothendieck Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier]
• Publié dans The Lancet Respiratory Medicine le 23/10/2020

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Résumé : Background : Non-invasive ventilation (NIV) and oxygen therapy (high-flow nasal oxygen [HFNO] or standard oxygen) following extubation have never been compared in critically ill patients with obesity. We aimed to compare NIV (alternating with HFNO or standard oxygen) and oxygen therapy (HFNO or standard oxygen) following extubation of critically ill patients with obesity. Methods : In this multicentre, parallel group, pragmatic randomised controlled trial, conducted in 39 intensive care units in France, critically ill patients with obesity undergoing extubation were randomly assigned (1:1) to either the NIV group or the oxygen therapy group. Two randomisations were performed: first, randomisation to either NIV or oxygen therapy, and second, randomisation to either HFNO or standard oxygen (also 1:1), which was nested within the first randomisation. Blinding of the randomisation was not possible, but the statistician was masked to group assignment. The primary outcome was treatment failure within 3 days after extubation, a composite of reintubation for mechanical ventilation, switch to the other study treatment, or premature discontinuation of study treatment. The primary outcome was analysed by intention to treat. Effect of medical and surgical status was assessed. The reintubation within 3 days was analysed by intention to treat and after a post-hoc crossover analysis. This study is registered with ClinicalTrials.gov number NCT04014920. Findings : From Oct 2, 2019, to July 17, 2021, of the 1650 screened patients, 981 were enrolled. Treatment failure occurred in 66 (13·5%) of 490 patients in the NIV group and in 130 (26·5%) of 491 patients in the oxygen-therapy group (relative risk 0·43; 95% CI 0·31–0·60, p<0·0001). Medical or surgical status did not modify the effect of NIV group on the treatment-failure rate. Reintubation within 3 days after extubation was similar in the non-invasive ventilation group and in the oxygen therapy group in the intention-to-treat analysis (48 (10%) of 490 patients and 59 (12%) of 491 patients, p=0·26) and lower in the NIV group than in the oxygen-therapy group in the post-hoc cross-over (51 (9%) of 560 patients and 56 (13%) of 421 patients, p=0·037) analysis. No severe adverse events were reported. Interpretation : Among critically ill adults with obesity undergoing extubation, the use of NIV was effective to reduce treatment-failure within 3 days. Our results are relevant to clinical practice, supporting the use of NIV after extubation of critically ill patients with obesity. However, most of the difference in the primary outcome was due to patients in the oxygen therapy group switching to NIV, and more evidence is needed to conclude that an NIV strategy leads to improved patient-centred outcomes.

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Fichiers liés : 2023 De jong et al., Effect of non.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Philippe GaudardHélène DavidPatrice BideauxPierre SicardJean-Paul CristolGilles GuillonSylvain RichardPascal ColsonAnne Virsolvy
• Organismes : Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] Centre Hospitalier Régional Universitaire [Montpellier] Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046]
• Publié dans International Journal of Molecular Sciences le 03/05/2024

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Résumé : Acute heart failure (AHF) due to acute myocardial infarction (AMI) is likely to involve cardiogenic shock (CS), with neuro-hormonal activation. A relationship between AHF, CS and vasopressin response is suspected. This study aimed to investigate the implication of vasopressin on hemodynamic parameters and tissue perfusion at the early phase of CS complicating AMI. Experiments were performed on male Wistar rats submitted or not to left coronary artery ligation (AMI and Sham). Six groups were studied Sham and AMI treated or not with either a vasopressin antagonist SR-49059 (Sham-SR, AMI-SR) or agonist terlipressin (Sham-TLP, AMI-TLP). Animals were sacrificed one day after surgery (D1) and after hemodynamic parameters determination. Vascular responses to vasopressin were evaluated, ex vivo, on aorta. AHF was defined by a left ventricular ejection fraction below 40%. CS was defined by AHF plus tissue hypoperfusion evidenced by elevated serum lactate level or low mesenteric oxygen saturation (SmO2) at D1. Mortality rates were 40% in AMI, 0% in AMI-SR and 33% in AMI-TLP. Immediately after surgery, a sharp decrease in SmO2 was observed in all groups. At D1, SmO2 recovered in Sham and in SR-treated animals while it remained low in AMI and further decreased in TLP-treated groups. The incidence of CS among AHF animals was 72% in AMI or AMI-TLP while it was reduced to 25% in AMI-SR. Plasma copeptin level was increased by AMI. Maximal contractile response to vasopressin was decreased in AMI (32%) as in TLP- and SR- treated groups regardless of ligation. Increased vasopressin secretion occurring in the early phase of AMI may be responsible of mesenteric hypoperfusion resulting in tissue hypoxia. Treatment with a vasopressin antagonist enhanced mesenteric perfusion and improve survival. This could be an interesting therapeutic strategy to prevent progression to cardiogenic shock.

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Fichiers liés : 2023 Gaudard et al., Involvement of Vasopressin in.pdf

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• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/01/2023
• Auteurs : Michael J O'DonohueMonique AxelosSarah-Louise FilleuxChavance YannLerayer Pierre-YvesAigue VéroniqueJohnny BeaugrandHelene FulcrandPhilippe GerardinJean-Denis MathiasVirginie Vandenbossche Maréchal
• Organismes : Toulouse Biotechnology Institute Département Aliments, produits biosourcés et déchets - INRAE Département Aliments, produits biosourcés et déchets - INRAE Direction de la communication Auteur indépendant Auteur indépendant Auteur indépendant Unité de recherche sur les Biopolymères, Interactions Assemblages Ingénierie des Agro-polymères et Technologies Émergentes Laboratoire d'Etudes et de Recherche sur le Matériau Bois Laboratoire d'ingénierie pour les systèmes complexes Laboratoire de Chimie Agro-Industrielle

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Résumé : La biomasse semble un remède miracle pour réduire nos émissions de gaz à effet de serre et atténuer le changement climatique, particulièrement pour le secteur du bâtiment, responsable de près d’un quart des émissions en France. Construire en bois, paille, tournesol, chanvre répond-il à toutes les questions ?

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Fichiers liés : 2023_O'Donohue_RESSOURCES#3_Chapitre Futurs _Le Biosourcé.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Hongliang MaXiaojun LiJiangyuan ZengXiang ZhangJianzhi DongNengcheng ChenLei FanMorteza SadeghiFrédéric FrappartXiangzhuo LiuMengjia WangHuan WangZheng FuZanpin XingPhilippe CiaisWigneron J.-P.
• Organismes : Interactions Sol Plante Atmosphère Wuhan University [China] Interactions Sol Plante Atmosphère Aerospace Information Research Institute Aerospace Information Research Institute China University of Geosciences [Wuhan] Massachusetts Institute of Technology Tianjin University Wuhan University [China] China University of Geosciences [Wuhan] Southwest University [Chongqing] California Department of Water Resources Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Chinese Academy of Sciences [Beijing] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Interactions Sol Plante Atmosphère
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : Recently, large efforts have been made to develop surface soil moisture (SSM) products based on observations from passive microwave L-band satellites at the global scale. Despite vast previous efforts to assess satellite SSM products based on in situ data, the performance of L-band SSM products remains still little known over the tropical areas including the rainforests. To close this knowledge gap, a comprehensive evaluation of five L-band SSM products from the Soil Moisture and Ocean Salinity (SMOS) and Soil Moisture Active Passive (SMAP) satellites, including SMOS-IC, SMAP SCA-V, DCA, and MTDCA, as well as the recently developed SMAP INRAE-BORDEAUX (SMAP-IB) was conducted in tropical areas from 2015 to 2020. The investigation was implemented by using in situ observations, and expanded by the Triple Collocation Analysis (TCA) and double instrumental variable (IVd) methods. The results revealed that all the five L-band SSM products show a good capacity to estimate SSM in most moderately vegetated areas of the tropical areas while they exhibit some uncertainties in dense vegetation (e.g., rainforests). The SSM climatology of the five L-band products in rainforests agreed generally well with that of in situ measurements especially for SMOS-IC (R = 0.75), followed by SMAP-IB (R = 0.72). Notably, the newly developed SMAP-IB shows satisfactory performance in the tropics with the highest R of 0.73 and the smallest unbiased root mean square difference (ubRMSD) of 0.041 m3/m3 from the study based on in situ SM data, and R of >0.81 from the combined TCA/IVd method in most vegetation conditions. SMAP-DCA SSM demonstrates comparable performance to SMAP-SCA-V (R = 0.66) from the in situ based analysis. This study is expected to deepen our understanding on the skill of L-band SSM products in tropical areas and further promote possible upgrades in algorithms and applications in these regions.

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Fichiers liés : 1-s2.0-S0034425722004503-am.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Maxence ButtardGuilhem MartinXavier BataillonGilles RenouPierre LhuissierJulie VillanovaBéchir ChehabPhilippe JarryJean-Jacques BlandinPatricia Donnadieu
• Organismes : Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés European Synchrotron Radiation Facility [Grenoble] Constellium Technology Center Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés Science et Ingénierie des Matériaux et Procédés
• Publié dans Additive Manufacturing le 25/10/2020

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Résumé : High-strength aluminium alloys from the 2XXX, 6XXX, and 7XXX series suffer from severe hot cracking issues during 3D printing. Thus, there is a need to design new alloys with an improved hot cracking resistance while taking advantage of the non-equilibrium processing conditions of laser powder bed fusion to achieve optimized properties. Here, we report the successful fabrication of a new Al-Mn-Ni-Cu-Zr alloy designed for L-PBF. The asbuilt microstructure was characterized at different scales using synchrotron X-ray nano-tomography and microscopy with a special focus on automated crystallographic orientation mapping (ACOM) in transmission electron microscopy. Based on this multiscale microstructural investigation, we identify various mechanisms involving the presence of a locally ordered liquid during solidification under conditions typical of additive manufacturing. This local liquid ordering is often defined as Icosahedral Short Range Order (ISRO). The multiple consequences of ISRO in the liquid on the hierarchical microstructure inherited from additive manufacturing are discussed. ISRO enables refinement of the grain size thus improving the processability via an increase of the hot cracking resistance, producing equiaxed grains and twinned dendrites contributing to randomizing the crystallographic texture, and possibly extending supersaturated solid solutions through a cage effect. It is concluded that promoting ISRO should be considered a promising pathway to design alloys for additive manufacturing with good processability and optimized properties.

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Fichiers liés : Final_version.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/01/2023
• Auteurs : Lena DelpechStefano AlbertiKonstantinos AvramidisAline AyreaultTristan BatalJean-Michel BernardFrancis BouqueyIoannis ChelisFrederic ClairetElodie CorbelLouis DoceulFrederic DurandRemi DumontTheo FonghettiGerd GantenbeinPascal GaribaldiGerardo GiruzziTim GoodmanJean-Philippe HoggeStefan IllyJohn JelonnekJianbo JinHeinrich LaquaFrancois LegrandChristophe LievinPhilippe MagaudPatrick MagetPierre ManasStefan MarsenXavier Regal-MezinPatrick MollardDavid MouyonLaurent NicolasAdam OuerfelliIoannis PagonakisBenjamin RobinetTobias RuessBenjamin SantraineManfred ThummZisis Ioannidis
• Organismes : Institut de Recherche sur la Fusion par confinement Magnétique Swiss Plasma Center National and Kapodistrian University of Athens THALES [France] Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique National and Kapodistrian University of Athens Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Swiss Plasma Center Swiss Plasma Center Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Max Planck Institute for Plasma physics THALES [France] THALES [France] Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Max Planck Institute for Plasma physics Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Institut de Recherche sur la Fusion par confinement Magnétique Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Institut de Recherche sur la Fusion par confinement Magnétique Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Institut de Recherche sur la Fusion par confinement Magnétique Karlsruhe Institute of Technology = Karlsruher Institut für Technologie Karlsruhe Institute of Technology = Karlsruher Institut für Technologie
• Publié dans Fusion Engineering and Design le 24/10/2020

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Résumé : Abstract The mission of WEST (tungsten-W Environment in Steady-state Tokamak) is to explore long pulse operation in a full tungsten (W) environment for preparing next-step fusion devices (ITER and DEMO) with a focus on testing the ITER actively cooled W divertor in tokamak conditions. Following the successful completion of phase 1 (2016-2021), phase 2 started in December 2022 with the lower divertor made entirely of actively cooled ITER-grade tungsten mono-blocks. A boronization prior the first plasma attempt allowed for a smooth startup with the new divertor. Despite the reduced operating window due to tungsten, rapid progress has been made in long pulse operation, resulting in discharges with a pulse length of 100 s and an injected energy of around 300 MJ per discharge. Plasma startup studies were carried out with equatorial boron nitride limiters to compare them with tungsten limiters, while Ion Cyclotron Resonance Heating assisted startup was attempted. High fluence operation in attached regime, which was the main thrust of the first campaigns, already showed the progressive build up of deposits and appearance of dust, impacting the plasma operation as the plasma fluence increased. In total, the cumulated injected energy during the first campaigns reached 43 GJ and the cumulated plasma time exceeded 5 h. Demonstration of controlled X-Point Radiator regime is also reported, opening a promising route for investigating plasma exhaust and plasma-wall interaction issues in more detached regime. This paper summarises the lessons learned from the manufacturing and the first operation of the ITER-grade divertor, describing the progress achieved in optimising operation in a full W environment with a focus on long pulse operation and plasma wall interaction.

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