Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Jean-François David CadranelIsabelle Ollivier-HourmandJacques CadranelThierry ThevenotHonoré ZougmoreEric Nguyen-KhacChristophe BureauManon AllaireJean-Baptiste NousbaumVéronique Loustaud-RattiXavier CaussePhilippe SogniBertrand HanslikMarc BourliereJean-Marie PeronNathalie Ganne-CarrieThong DaoDominique ThabutBernard. MaitreNabil DebziRyad SmadhiRoger SombieRaimi KpossouOlivier NouelJulien BissonnetteIsaac RuizMourad MedmounSergio Negrin DastisPierre DeltenreFlorent ArtruChantal RaherisonLaure ElkriefTristan Lemagoarou
• Organismes : CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Service d'Hépatologie [CHRU Besançon] CHU Amiens-Picardie Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 UPJV Centre Hospitalier Universitaire de Toulouse Centre de recherche sur l'Inflammation CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire de Brest Ciblage individuel et prévention des risques de traitements immunosupresseurs et de la transplantation Institut Cochin Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale Hôpital Saint-Joseph [Marseille] Centre Hospitalier Universitaire de Toulouse Hôpital Avicenne [AP-HP] Centre de Recherche des Cordeliers CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Pitié-Salpêtrière [AP-HP] Centre de recherche en épidémiologie et santé des populations Service Addictologie [CHU Nîmes] Sorbonne Université Centre Hospitalo-Universitaire Mustapha Bacha
• Publié dans BMC Gastroenterology le 01/11/2020

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Résumé : Background The Hepatic hydrothorax is a pleural effusion related to portal hypertension; its diagnosis and therapeutic management may be difficult. The aims of this article are which follows: To gather the practices of hepatogastroenterologists or pulmonologists practitioners regarding the diagnosis and management of the hepatic hydrothorax. Methods Practitioners from 13 French- speaking countries were invited to answer an online questionnaire on the hepatic hydrothorax diagnosis and its management. Results Five hundred twenty-eight practitioners (80% from France) responded to this survey. 75% were hepatogastroenterologists, 20% pulmonologists and the remaining 5% belonged to other specialities. The Hepatic hydrothorax can be located on the left lung for 64% of the responders (66% hepatogastroenterologists vs 57% pulmonologists; p = 0.25); The Hepatic hydrothorax can exist in the absence of clinical ascites for 91% of the responders (93% hepatogastroenterologists vs 88% pulmonologists; p = 0.27). An Ultrasound pleural scanning was systematically performed before a puncture for 43% of the responders (36% hepatogastroenterologists vs 70% pulmonologists; p < 0.001). A chest X-ray was performed before a puncture for 73% of the respondeurs (79% hepatogastroenterologists vs 54% pulmonologists; p < 0.001). In case of a spontaneous bacterial empyema, an albumin infusion was used by 73% hepatogastroenterologists and 20% pulmonologists ( p < 0.001). A drain was used by 37% of the responders (37% hepatogastroenterologists vs 31% pulmonologists; p = 0.26).An Indwelling pleural catheter was used by 50% pulmonologists and 22% hepatogastroenterologists ( p < 0.01). TIPS was recommended by 78% of the responders (85% hepatogastroenterologists vs 52% pulmonologists; p < 0.001) and a liver transplantation, by 76% of the responders (86% hepatogastroenterologists vs 44% pulmonologists; p < 0.001). Conclusions The results of this large study provide important data on practices of French speaking hepatogastroenterologists and pulmonologists; it appears that recommendations are warranted.

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Fichiers liés : s12876-023-02931-z.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2023
• Auteurs : Daniela MatuozzoEstelle TalouarnAstrid MarchalPeng ZhangJeremy ManryYoann SeeleuthnerYu ZhangAlexandre BolzeMatthieu ChaldebasBaptiste MilisavljevicAdrian GervaisPaul BastardTakaki AsanoLucy BizienFederica BarzaghiHassan AbolhassaniAhmad Abou TayounAlessandro AiutiIlad Alavi DarazamLuis AllendeRebeca Alonso-AriasAndrés Augusto AriasGokhan AytekinPeter BergmanSimone BondesanYenan BrycesonIngrid BustosOscar Cabrera-MaranteSheila CarcelPaola CarreraGiorgio CasariKhalil ChaïbiRoger ColobranAntonio Condino-NetoLaura CovillOttavia DelmonteLoubna El ZeinCarlos FloresPeter GregersenMarta GutFilomeen HaerynckRabih HalwaniSelda HancerliLennart HammarströmNevin HatipoğluAdem KarbuzSevgi KelesChristèle KyhengRafael Leon-LopezJose Luis FrancoDavood MansouriJavier Martinez-PicadoOzge Metin AkcanIsabelle MigeottePierre-Emmanuel MorangeGuillaume MorelleAndrea Martin-NaldaGiuseppe NovelliAntonio NovelliTayfun OzcelikFigen PalabiyikQiang Pan-HammarströmRebeca Pérez de DiegoLaura Planas-SerraDaniel PleguezueloCarolina PrandoAurora PujolLuis Felipe ReyesJacques RivièreCarlos Rodriguez-GallegoJulian RojasPatrizia Rovere-QueriniAgatha SchlüterMohammad ShahrooeiAli SobhPere Soler-PalacinYacine Tandjaoui-LambiotteImran TipuCristina TresoldiJesus TroyaDiederik van de BeekMayana ZatzPawel ZawadzkiSaleh Zaid Al-MuhsenMohammed Faraj AlosaimiFahad AlsohimeHagit Baris-FeldmanManish ButteStefan ConstantinescuMegan CooperClifton DalgardJacques FellayJames HeathYu-Lung LauRichard LiftonTom ManiatisTrine MogensenHorst von BernuthAlban LermineMichel VidaudAnne BolandJean-François DeleuzeRobert NussbaumAmanda Kahn-KirbyFrance MentreSarah TubianaGuy GorochovFlorence TubachPierre HausfaterLaurent AbelSaleh Al-MuhsenFahd Al-MullaMark AndersonEvangelos AndreakosAndrés AriasHagit Baris FeldmanAlexandre BelotCatherine BiggsDusan BogunovicAnastasiia BondarenkoAhmed BousfihaPetter BrodinYenan BrycesonCarlos BustamanteSamya ChakravortyJohn ChristodoulouMurkesh DesaiBeth DroletJamila El 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BuenoHuda BukhariJacinta BustamanteJuan José Cáceres AgraRuggero CapraRaphaël CarapitoMaria CarrabbaCarlos CasasnovasMarion CaserisIrene CassanitiMartin CastelleFrancesco CastelliMartín Castillo de VeraMateus CastroEmilie CatherinotJale Bengi CelikAlessandro CeschiMartin ChalumeauBruno CharbitMatthew ChengPère ClavéBonaventura ClotetAnna CodinaYves CohenCloé ComarmondAlain CombesPatrizia ComoliAngelo CorsicoBetul SozeriTaner CoşkunerAleksandar CvetkovskiCyril CyrusDavid DalmauFrançois DanionDavid Ross DarleyVincent DasNicolas DaubyStéphane DaugerPaul de MunterLoic de PontualAmin DehbanGeoffroy DelplancqAlexandre DemouleIsabelle DesguerreAntonio Di SabatinoJean-Luc DiehlStephanie DobbelaereElena Domínguez-GarridoClément DubostOlov EkwallŞefika Elmas BozdemirMarwa ElnagdyMelike EmirogluAkifumi EndoEmine Hafize ErdenizSelma Erol AytekinMaria Pilar Etxart LasaRomain EuvrardGiovanna FabioLaurence FaivreAntonin FalckMuriel FartoukhMorgane FaureMiguel Fernandez ArqueroRicard FerrerJose FerreresBruno FrancoisVictoria FumadóKitty FungFrancesca FuscoAlenka GagroBlanca Garcia SolisPierre GarçonPascale GaussemZeynep GayretliJuana Gil-HerreraLaurent GilardinAudrey Giraud GatineauMònica Girona-AlarcónKaren Alejandra Cifuentes GodínezJean-Christophe GoffardNacho GonzalesLuis Gonzalez-GranadoRafaela González-MontelongoAntoine GuerderBelgin GülhanVictor Daniel GumucioLeif Gunnar HanitschJan GunstJérome HadjadjTetyana HariyanNevin HatipogluDeniz HeppekcanElisa Hernandez-BritoPo-Ki HoMaría Soledad Holanda-PeñaJuan HorcajadaSami HraiechLinda HumbertIvan HungAlejandro IglesiasAntonio Íñigo-CamposMatthieu JammeMaría Jesús ArranzMarie-Thérèse JimenoIolanda JordanSaliha Kanik-YüksekYalcin Burak KaraAydın KarahanKadriye Kart YasarOzgur KasapcopurKenichi KashimadaYasemin Kendir DemirkolYasutoshi KidoCan KizilAhmet Osman KılıçAdam KlocperkAntonia KoutsoukouZbigniew KrólHatem KsouriPaul KuentzArthur KwanYat Wah M. KwanJanette KwokJean-Christophe LagierDavid LamVicky LampropoulouFanny LanternierFleur Le BourgeoisYee-Sin LeoRafael Leon LopezDaniel LeungMichael LevinMichael LevyRomain LévyZhi LiDaniele LilleriEdson Jose Adrian Bolanos LimaAgnès LinglartEduardo López-CollazoJosé Lorenzo-SalazarCéline LouapreCatherine LubetzkiKwok-Cheung LungCharles-Edouard LuytDavid LyeCinthia MagnoneEnrico MarchioniCarola MarioliMajid MarjaniLaura MarquesJesus Marquez PereiraAndrea Martín-NaldaDavid Martínez PueyoIciar MarzanaCarmen Mata-MartínezAlexis MathianLarissa MatosGail MatthewsJulien MayauxRaquel Mclaughlin-GarciaPhilippe MeerssemanJean-Louis MègeArmand Mekontso-DessapIsabelle MelkiFederica MeloniJean-François MeritetPaolo MerlaniÖzge Metin AkcanIsabelle MeytsMehdi MezidiMaude MillereuxMatthieu MillionTristan MiraultClotilde MircherMehdi MirsaeidiYoko MizoguchiBhavi ModiFrancesco MojoliElsa MoncombleAbián Montesdeoca MeliánAntonio Morales MartinezFrancisco MorandeiraCléemence MordacqStéphane MoulyAdrián Muñoz-BarreraCyril NafatiShintaro NagashimaYu NakagamaBénédicte NevenJoão Farela NevesLisa NgYuk-Yung NgHubert NiellyYeray Novoa MedinaEsmeralda Nuñez CuadrosJ. Gonzalo Ocejo-VinyalsKeisuke OkamotoMehdi OualhaAmani OuedraniTayfun ÖzçelikAslinur Ozkaya-ParlakayMichele PaganiMaria PapadakiChristophe ParizotPhilippe ParolaTiffany PascreauStéphane PaulEstela Paz-ArtalSigifredo PedrazaNancy Carolina González PellecerSilvia PellegriniXosé Luis Pérez-FernándezAurélien PhilippeQuentin PhilippotAdrien PicodMarc Pineton de ChambrunAntonio PirallaDominique PloinJulien PoissyGéraldine PonceletGaryphallia PoulakouMarie PoulettyPersia PourshahnazariJia Li Qiu-ChenPaul QuentricThomas RambaudDidier RaoultViolette RaoultAnne-Sophie RebillatClaire RedinLéa ResminiPilar RicartJean-Christophe RichardRaúl Rigo-BonninNadia RivetGemma Rocamora-BlanchMathieu RoderoCarlos RodrigoLuis Antonio RodriguezAgustí Rodriguez-PalmeroCarolina Soledad RomeroAnya RothenbuhlerDamien RouxNikoletta RovinaFlore RozenbergYvon RuchMontse RuizMaria Yolanda Ruiz del PradoJuan Carlos Ruiz-RodriguezJoan Sabater-RieraKai SaksMaria SalagianniOliver SanchezAdrián Sánchez-MontalváSilvia Sánchez-RamónLaire SchidlowskiAgatha SchluterJulien SchmidtMatthieu SchmidtCatharina SchuetzCyril SchweitzerFrancesco ScolariAnna SedivaLuis SeijoAnalia Gisela SeminarioDamien SenePiseth SengSevtap SenogluMikko SeppänenAlex Serra LlovichAnna ShcherbinaVirginie SiguretEleni SioutiDavid SmadjaNikaia SmithXavier SolanichJordi Solé-ViolánCatherine SolerPere Soler-PalacínBetül SözeriGiulia Maria StellaYuriy StepanovskiyAnnabelle StoclinFabio Silvio TacconeJean-Luc TaupinSimon TavernierLoreto Vidaur TelloBenjamin TerrierGuillaume ThieryChristian ThorballKarolina ThornCaroline ThumerelleMartin TolstrupGabriele TomasoniJulie ToubianaJosep Trenado AlvarezVasiliki TriantafylliaSophie Trouillet-AssantJesús TroyaOwen TsangLiina TserelEugene TsoAlessandra TucciŞadiye Kübra Tüter ÖzMatilde Valeria UrsiniTakanori UtsumiYurdagul UzunhanPierre VabresJuan Valencia-RamosAna Maria van den RymIsabelle VandernootValentina Velez-SantamariaSilvia Patricia Zuniga VelizMateus VidigalViel SCédric VillainMarie Vilaire-MeunierJudit Villar-GarcíaAudrey VincentGuillaume VoiriotAlla VolokhaFanny VuottoEls WautersJoost WautersAlan WuTak-Chiu WuAysun YahşiOsman YesilbasMehmet YildizBarnaby YoungUfuk YükselmişMayana ZatzMarco ZeccaValentina ZuccaroJens van PraetBart LambrechtEva van BraeckelCédric BosteelsLevi HosteEric HosteFré BautersJozefien de ClercqCatherine HeijmansHans SlabbynckLeslie NaesensBenoit FlorkinCécile BoulangerDimitri VanderlindenLaurent AbelMatilda BerkellValerio CarelliAlessia FiorentinoSurbi MalhotraAlessandro MattiaccioTommaso PippucciMarco SeriEvelina TacconelliMichiel van AgtmaelAnne Geke AlgeraBrent AppelmanFrank van BaarleDiane BaxMartijn BeudelHarm Jan BogaardMarije BomersPeter BontaLieuwe BosMichela BottaJustin de BrabanderGodelieve de BreeSanne de BruinDavid BuisMarianna BugianiEsther BulleOsoul Chouchane Alex ClohertyMirjam DijkstraDave DongelmansRomein DujardinPaul ElbersLucas FleurenSuzanne Geerlings Theo GeijtenbeekArmand GirbesBram GoorhuisMartin GrobuschFlorianne HafkampLaura HagensJorg HamannVanessa HarrisRobert HemkeSabine HeunksMarkus HollmannJanneke HornJoppe HoviusMenno de JongRutger KoningEndry LimNiels van MourikJeaninne NellenEsther NossentFrederique PaulusEdgar PetersDan Pina-FuentesTom van der PollBennedikt PreckelJan PrinsJorinde RaasveldTom ReijndersMaurits de RotteMichiel SchinkelMarcus SchultzFemke SchrauwenAlex SchuurmansJaap SchuurmansKim SigaloffMarleen SlimPatrick SmeeleMarry SmitCornelis StijnisWillemke StilmaCharlotte TeunissenPatrick ThoralAnissa TsonasPieter TuinmanMarc van der ValkDenise VeeloCarolien VollemanHeder de VriesLonneke VughtMichèle van VugtDorien WoutersA. ZwindermanMatthijs BrouwerW. Joost WiersingaAlexander VlaarDiederik van de BeekMiranda TompkinsCamille AlbaAndrew SnowDaniel HupaloJohn RosenbergerGauthaman SukumarMatthew WilkersonXijun ZhangJustin LackAndrew OlerKerry DobbsJeffrey DanielsonAndrea BiondiLaura Rachele BettiniMariella D’angio’Ilaria BerettaLuisa ImbertiAlessandra SottiniVirginia QuaresimaEugenia Quiros-RoldanCamillo RossiIsabelle MeytsShen-Ying ZhangAnne PuelLuigi NotarangeloStéphanie Boisson-DupuisHelen SuBertrand BoissonEmmanuelle JouanguyJean-Laurent CasanovaQian ZhangLaurent AbelAurélie CobatPierre-Emmanuel Morange
• Organismes : Human genetics of infectious diseases : Mendelian predisposition Génétique Physiologie et Systèmes d'Elevage Imagine - Institut des maladies génétiques (IHU) Xi'an Jiaotong University Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Département de Pédiatrie et maladies infectieuses [CHU Necker] University of Cincinnati Helix [San Mateo, CA] Rockefeller University [New York] Rockefeller University [New York] Imagine - Institut des maladies génétiques (IHU) Human genetics of infectious diseases : Mendelian predisposition Hôpital Necker - Enfants Malades [AP-HP] Rockefeller University [New York] St. Giles Laboratory of Human Genetics of Infectious Diseases Imagine - Institut des maladies génétiques (IHU) IRCCS San Raffaele Scientific Institute [Milan, Italie] Tehran University of Medical Sciences Karolinska Institutet = Karolinska Institute [Stockholm] Al Jalila Genomics Center of Excellence, Al Jalila Children’s Specialty Hospital IRCCS Ospedale San Raffaele [Milan, Italy] Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] Shahid Beheshti University of Medical Sciences [Tehran] Rockefeller University [New York] Universidad de Antioquia = University of Antioquia [Medellín, Colombia] Karolinska University Hospital [Stockholm] Karolinska Institutet = Karolinska Institute [Stockholm] IRCCS San Raffaele Scientific Institute [Milan, Italie] Karolinska Institutet = Karolinska Institute [Stockholm] University of Bergen IRCCS San Raffaele Scientific Institute [Milan, Italie] IRCCS Ospedale San Raffaele [Milan, Italy] Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] Hôpital Avicenne [AP-HP] CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Vall d'Hebron Research Institute - Institut de Recerca Vall d’Hebron Vall d'Hebron University Hospital [Barcelona] Institute of Biomedical Sciences - Department of Immunology [Sao Paulo] National Institutes of Health [Bethesda, MD, USA] Faculty of Sciences [Lebanese University] | Faculté des Sciences [Université Libanaise] Instituto Tecnologico y de Energias Renovables [Tenerife, Spain] Hospital Universitario Nuestra Señora de Candelaria - University Hospital of the Nuestra Señora de Candelaria [Santa Cruz de Tenerife, Spain] Instituto de Salud Carlos III [Madrid] Universidad Fernando Pessoa Canarias [Las Palmas de Gran Canaria, Spain] Centro Nacional de Analisis Genomico [Barcelona] Ghent University Hospital = Hôpital Universitaire de Gand = Universitair Ziekenhuis Gent [Gent] University of Sharjah Department of Biosciences and Nutrition [Karolinska Insitutet, Sueden] Necmettin Erbakan University [Konya, Turquie] Universidad de Antioquia = University of Antioquia [Medellín, Colombia] Shahid Beheshti University of Medical Sciences [Tehran] IrsiCaixa (Institut de Recerca de la Sida) Institute of Health Carlos III Universitat de VIC, Universitat Central de Catalunyo = University of Vic-Central University of Catalonia Institut de Recherche Interdisciplinaire en Biologie Humaine et moléculaire = Insitute of Interdisciplinary Research [Bruxelles, Belgique] Université libre de Bruxelles = Free University of Brussels Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research Infection et inflammation Vall d'Hebron Research Institute - Institut de Recerca Vall d’Hebron Vall d'Hebron University Hospital [Barcelona] Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie] IRCCS Ospedale Pediatrico Bambino Gesù = Bambino Gesù Children’s Hospital Bilkent University [Ankara] Department of Biosciences and Nutrition [Karolinska Insitutet, Sueden] Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute Hospitalet de Llobregat Centre for Biomedical Research on Rare Diseases [Barcelona, Spain] Instituto de Salud Carlos III [Madrid] nstituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Hospital Pequeno Príncipe , Curitiba Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute CIBER de Enfermedades Raras (CIBERER) Institució Catalana de Recerca i Estudis Avançats = Catalan Institution for Research and Advanced Studies Pandemic Sciences Institute, University of Oxford, Oxford Vall d'Hebron Research Institute - Institut de Recerca Vall d’Hebron Vall d'Hebron University Hospital [Barcelona] Dept. of Clinical Sciences, University Fernando Pessoa Canarias , Las Palmas de Gran Canaria Universidad de Antioquia = University of Antioquia [Medellín, Colombia] IRCCS San Raffaele Scientific Institute [Milan, Italie] Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute CIBER de Enfermedades Raras (CIBERER) Specialized Immunology Laboratory of Dr Shahrooei, [Ahvaz, Iran] Catholic University of Leuven = Katholieke Universiteit Leuven Mansoura University [Egypt] Vall d'Hebron University Hospital [Barcelona] Vall d'Hebron Research Institute - Institut de Recerca Vall d’Hebron Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona Service de maladies infectieuses et tropicales [CHU Avicenne] Ospedale San Raffaele Hospital Universitario Infanta Leonor [Madrid] Universiteit van Amsterdam = University of Amsterdam Universidade de São Paulo = University of São Paulo Uniwersytet im. Adama Mickiewicza w Poznaniu = Adam Mickiewicz University in Poznań Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Fondation Jean Dausset - Centre d’Études du Polymorphisme Humain Centre de référence, d’innovation, d’expertise et de transfert Génétique Evolutive Humaine - Human Evolutionary Genetics Immunologie intégrative des tumeurs et immunothérapie des cancers Agents infectieux, résistance et chimiothérapie - UR UPJV 4294 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Immuno-Rhumatologie Moléculaire Immuno-Rhumatologie Moléculaire Immuno-Rhumatologie Moléculaire Centre International de Recherche en Infectiologie Virology and human respiratory Pathologies - Virology and human respiratory Pathologies [CIRI]
• Publié dans Genome Medicine le 24/10/2020

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Résumé : Background - We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods - We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results - No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P = 1.1 × 10) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3-8.2], P = 2.1 × 10). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1-2635.4], P = 3.4 × 10), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3-8.4], P = 7.7 × 10). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10). Conclusions - Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

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Fichiers liés : s13073-023-01173-8.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 30/11/2023
• Auteurs : Stephan EhrmannFrançois BarbierJulien DemiselleJean-Pierre QuenotJean-Etienne HerbrechtDamien RouxJean-Claude LacheradeMickaël LandaisPhilippe SeguinDavid SchnellAnne VeinsteinPhilippe GouinSigismond LasockiQin LuGaëtan BeduneauMartine FerrandiereGaëtan PlantefèveClaire Dahyot-FizelierNader ChebibEmmanuelle MercierNathalie Heuzé-Vourc’hRenaud RespaudNicolas GrégoireDenis GarotMai-Anh NayFerhat MezianiPascal AndreuRaphaël Clere-JehlNoémie ZucmanMarie-Ange AzaïsMarjorie Saint-MartinCharlotte Salmon GandonnièreDalila BenzekriHamid MerdjiElsa Tavernier
• Organismes : Centre d’Etude des Pathologies Respiratoires [Tours] Centre d’Investigation Clinique [CHRU Tours] Centre Hospitalier Régional d'Orléans Nanomédecine Régénérative Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand Hôpital de Hautepierre [Strasbourg] Hôpital Louis Mourier - AP-HP [Colombes] Institut Necker Enfants-Malades Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier Le Mans (CH Le Mans) Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre Hospitalier d'Angoulême Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Archéologies et Sciences de l'Antiquité Centre Hospitalier Universitaire d'Angers CHU Pitié-Salpêtrière [AP-HP] Groupe de Recherche sur le Handicap Ventilatoire CHU Rouen Centre Hospitalier Régional Universitaire de Tours Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Hôpital de la Croix-Rousse [CHU - HCL] Université Claude Bernard Lyon 1 Centre Hospitalier Régional Universitaire de Tours Centre d’Etude des Pathologies Respiratoires [Tours] Pharmacologie des anti-infectieux et antibiorésistance [U 1070] Centre hospitalier universitaire de Poitiers = Poitiers University Hospital Université de Poitiers – UFR Santé [Faculté de Médecine et de Pharmacie] Centre d’Investigation Clinique [CHRU Tours] methodS in Patients-centered outcomes and HEalth ResEarch
• Publié dans New England Journal of Medicine le 29/10/2020

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Résumé : Background: Whether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear. Methods: In this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive inhaled amikacin at a dose of 20 mg per kilogram of ideal body weight once daily or to receive placebo for 3 days. The primary outcome was a first episode of ventilator-associated pneumonia during 28 days of follow-up. Safety was assessed. Results: A total of 850 patients underwent randomization, and 847 were included in the analyses (417 assigned to the amikacin group and 430 to the placebo group). All three daily nebulizations were received by 337 patients (81%) in the amikacin group and 355 patients (83%) in the placebo group. At 28 days, ventilator-associated pneumonia had developed in 62 patients (15%) in the amikacin group and in 95 patients (22%) in the placebo group (difference in restricted mean survival time to ventilator-associated pneumonia, 1.5 days; 95% confidence interval [CI], 0.6 to 2.5; P = 0.004). An infection-related ventilator-associated complication occurred in 74 patients (18%) in the amikacin group and in 111 patients (26%) in the placebo group (hazard ratio, 0.66; 95% CI, 0.50 to 0.89). Trial-related serious adverse effects were seen in 7 patients (1.7%) in the amikacin group and in 4 patients (0.9%) in the placebo group. Conclusions: Among patients who had undergone mechanical ventilation for at least 3 days, a subsequent 3-day course of inhaled amikacin reduced the burden of ventilator-associated pneumonia during 28 days of follow-up. (Funded by the French Ministry of Health; AMIKINHAL ClinicalTrials.gov number, NCT03149640; EUDRA Clinical Trials number, 2016-001054-17.).

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• Type de publi. : Communication dans un congrès
• Date de publi. : 28/11/2023
• Auteurs : Mohamed Said OughouEric BiotNicolas ArnaudAude Maugarny-CalèsPatrick LaufsPhilippe AndreyJasmine Burguet
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal

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Résumé : Morphogenesis is a process that spans several orders of magnitude in both time and space. Because it is generally impossible to follow developing organs all along growth, analyses typically rely on static data sampled at different developmental stages. We propose a model-based approach for the accurate dating of organs, allowing spatio-temporal reconstruction of organ morphogenesis over unlimited time windows, based on static data collected from different individuals. Although considered leaves in wild-type and mutant plants displayed contrasted final shapes and sizes, we revealed invariant, iterated developmental schemes, and identical critical time points, suggesting conserved morphogenetic modules. We provided evidence that modules determining local features may act independently of global leaf growth. In particular, we showed that serrations developing at different times and/or in different leaves grow in a remarkably synchronized way. In addition, graded differences in growth dynamics and final shapes of successive leaves suggest continuous variations in module expression. Altogether, we illustrated that our strategy is powerful to finely dissect multi-scale morphogenetic processes.

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• Type de publi. : Article dans une revue
• Date de publi. : 27/11/2023
• Auteurs : Odile FeysPierre CorvilainEtienne LabytMahdi MahmoudzadehLaura RoutierClaudine SculierNiall HolmesMatthew BrookesSerge GoldmanRudy RomainSergey MitryukovskiyAgustin Palacios-LaloyDenis SchwartzNacim BetrouniPhilippe DerambureFabrice WalloisVincent WensXavier de Tiège
• Organismes : Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis ULB Neuroscience Institute [Brussels] Mag4Health Euratechnologies Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 UPJV Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis School of Physics and Astronomy [Nottingham] School of Physics and Astronomy [Nottingham] ULB Neuroscience Institute [Brussels] Mag4Health Mag4Health Mag4Health Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant Lille Neurosciences & Cognition - U 1172 Lille Neurosciences & Cognition - U 1172 Groupe de Recherche sur l'Analyse Multimodale de la Fonction Cérébrale - UMR INSERM_S 1105 UPJV Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis ULB Neuroscience Institute [Brussels] Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis ULB Neuroscience Institute [Brussels]
• Publié dans Frontiers in Neuroscience le 24/10/2020

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Résumé : Cryogenic magnetoencephalography (MEG) enhances the presurgical assessment of refractory focal epilepsy (RFE). Optically pumped magnetometers (OPMs) are cryogen-free sensors that enable on-scalp MEG recordings. Here, we investigate the application of tri-axial OPMs [ 87 Rb (Rb-OPM) and 4 He gas (He-OPM)] for the detection of interictal epileptiform discharges (IEDs). IEDs were recorded simultaneously with 4 tri-axial Rb- and 4 tri-axial He-OPMs in a child with RFE. IEDs were identified visually, isolated from magnetic background noise using independent component analysis (ICA) and were studied following their optimal magnetic field orientation thanks to virtual sensors. Most IEDs (>1,000) were detectable by both He- and Rb-OPM recordings. IEDs were isolated by ICA and the resulting magnetic field oriented mostly tangential to the scalp in Rb-OPMs and radial in He-OPMs. Likely due to differences in sensor locations, the IED amplitude was higher with Rb-OPMs. This case study shows comparable ability of Rb-OPMs and He-OPMs to detect IEDs and the substantial benefits of triaxial OPMs to detect IEDs from different sensor locations. Tri-axial OPMs allow to maximize spatial brain sampling for IEDs detection with a limited number of sensors.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 27/11/2023
• Auteurs : Lea ProchassonMakram Mghezzi-HabellahArmelle RoisinMartine PalmaJean-Philippe RobinSteve de BossoreilleDavid CluetMaleke MouehliDidier DecimoAlexandra DesramesThibault ChazeMariette MatondoHélène DutartreMarie-Isabelle ThoulouzeFabrice LejeunePierre JalinotS. RétyVincent Mocquet
• Organismes : Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Centre International de Recherche en Infectiologie Virologie Structurale - Structural Virology Plateforme de Protéomique / Proteomics platform Plateforme de Protéomique / Proteomics platform Centre International de Recherche en Infectiologie Virologie Structurale - Structural Virology Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule Laboratoire de biologie et modélisation de la cellule

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Résumé : Abstract The hijacking of CRM1 export is an important step of the retroviral replication cycle. Here, we investigated the consequences of this hijacking for the host. During HTLV-1 infection, we identified the formation of a complex composed of Rex, CRM1 and the RNA helicase UPF1, leading to the nuclear retention of UPF1. We further showed how this leads to the inhibition of the nonsense mediated mRNA decay (NMD), known to have an antiviral function. Corroborating these results, we described a similar process with Rev, the functional homolog of Rex from HIV-1. Unexpectedly, we also found that, for HTLV-1, this process is coupled with the specific loading of UPF1 onto vRNA, independently of NMD. In this latter context, UPF1 positively regulates several steps of the viral replication cycle, from the nuclear export of vRNA to the production of mature viral particles.

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• Type de publi. :
• Date de publi. : 23/11/2023
• Auteurs : Pierre MorettoFrédéric GuittardPhilippe SouèresAnthony HerrelJosé de Jesus Castillo-ZamoraFranck RuffierThomas EngelsMatthieu VerdoucqChristophe GoupilMichaël GauthierBertrand TonduJulien SerresBruno Watier
• Organismes : Centre de Recherches sur la Cognition Animale - UMR5169 Centre de Biologie Intégrative NATURE INSPIRES CREATIVITY ENGINEERS LAB Équipe Mouvement des Systèmes Anthropomorphes Muséum national d'Histoire naturelle Institut des Sciences du Mouvement Etienne Jules Marey Institut des Sciences du Mouvement Etienne Jules Marey Centre National de la Recherche Scientifique Institut des Sciences du Mouvement Etienne Jules Marey Centre National de la Recherche Scientifique ENAC - Programme transverse Drones Laboratoire Interdisciplinaire des Energies de Demain Institut universitaire de France Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) Institut National des Sciences Appliquées Équipe Mouvement des Systèmes Anthropomorphes Aix Marseille Université Institut des Sciences du Mouvement Etienne Jules Marey Institut universitaire de France Équipe Mouvement des Systèmes Anthropomorphes

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Résumé : L'axe "Mouvement, Déplacement, Biomécanique Biorobotique" du GDR Biomim 2088 est centré sur l’étude du déplacement et du mouvement, observables du comportement organisé depuis la perception et traduisant l’action voire l’intention. Les recherches s’intéressent ici à la compréhension de ces mécanismes qui permettent de migrer, de fuir et de se dissimuler ou de poursuivre et attraper, enfin de se déplacer seul ou en groupe d’individus parfaitement coordonnés. Ces habiletés ont assuré à qui les a acquises une capacité de survie et l’efficacité des modèles biologiques peut être démontrée à différentes échelles, dans différents contextes et environnements. Ils inspirent des modélisations et prototypes de capteurs, d’actionneurs, de systèmes poly-articulés et de robots « durs ou mous », qui, en plus de suppléer l’homme dans ses tâches, permettent d’avancer sur la compréhension du vivant en testant des hypothèses issues de la biologie, des neurosciences, de la physique et de la mécanique.

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Fichiers liés : A - Intro MAH 2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 21/11/2023
• Auteurs : Sybren de HoogThomas WalshSarah AhmedAna Alastruey-IzquierdoBarbara AlexanderMaiken Cavling ArendrupEsther BabadyFeng-Yan BaiJoan-Miquel Balada-LlasatAndrew BormanAnuradha ChowdharyAndrew ClarkRobert ColgroveOliver CornelyTanis DinglePhilippe DufresneJeff FullerJean-Pierre GangneuxConnie GibasHeather GlasgowYvonne GräserJacques GuillotAndreas H. GrollGerhard HaaseKimberly HansonAmanda HarringtonDavid HawksworthRandall T HaydenMartin HoeniglVit HubkaKristie JohnsonJulianne V KusRuoyu LiJacques MeisMichaela LacknerFanny LanternierSixto Leal Jr.Francesca LeeShawn LockhartPaul LuethyIsabella MartinKyung J Kwon-ChungWieland MeyerM. Hong NguyenLuis Ostrosky-ZeichnerElizabeth PalavecinoPreeti PancholiPeter PappasGary ProcopScott RedheadDaniel D RhoadsStefan RiedelBryan StevensKaede Ota SullivanPaschalis VergidisEmmanuel RoilidesAmir SeyedmousaviLili TaoVania VicenteRoxana VitaleQi-Ming WangNancy L WengenackLars WestbladeNathan WiederholdP. Lewis WhiteChristina M WojewodaSean X Zhang
• Organismes : École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques
• Publié dans Journal of Clinical Microbiology le 01/11/2020

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Résumé : ABSTRACT The rapid pace of name changes of medically important fungi is creating challenges for clinical laboratories and clinicians involved in patient care. We describe two sources of name change which have different drivers, at the species versus the genus level. Some suggestions are made here to reduce the number of name changes. We urge taxonomists to provide diagnostic markers of taxonomic novelties. Given the instability of phylogenetic trees due to variable taxon sampling, we advocate to maintain genera at the largest possible size. Reporting of identified species in complexes or series should where possible comprise both the name of the overarching species and that of the molecular sibling, often cryptic species. Because the use of different names for the same species will be unavoidable for many years to come, an open access online database of the names of all medically important fungi, with proper nomenclatural designation and synonymy, is essential. We further recommend that while taxonomic discovery continues, the adaptation of new name changes by clinical laboratories and clinicians be reviewed routinely by a standing committee for validation and stability over time, with reference to an open access database, wherein reasons for changes are listed in a transparent way.

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• Type de publi. : Article dans une revue
• Date de publi. : 21/11/2023
• Auteurs : Candie JolyDelphine DesjardinsRaphaël PorcherHélène PéréThomas BruneauQian ZhangPaul BastardAurélie CobatLéa ResminiOlivia LenoirLaurent SavaleCamille LécurouxCéline VerstuyftAnne-Marie Roque-AfonsoDavid VeyerGabriel BaronMatthieu Resche-RigonPhilippe RavaudJean-Laurent CasanovaRoger Le GrandOlivier HerminePierre-Louis TharauxXavier Mariette
• Organismes : Infectious Diseases Models for Innovative Therapies Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Infectious Diseases Models for Innovative Therapies Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Université Paris Cité Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP] Université Paris Cité Institute of Botany [Beijing] Human genetics of infectious diseases : Mendelian predisposition Hôpital Necker - Enfants Malades [AP-HP] Rockefeller University [New York] Imagine - Institut des maladies génétiques (IHU) Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre] Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Centre de recherche en épidémiologie et santé des populations Service de Génétique Moléculaire Pharmacogénétique et Hormonologie [CHU Bicêtre] Physiopathologie et traitement des maladies du foie Hôpital Paul Brousse Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Hôtel-Dieu [Paris] Epidemiology and Clinical Statistics for Tumor, Respiratory, and Resuscitation | Epidémiologie Clinique, STatistique, pour la Recherche en Santé Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Imagine - Institut des maladies génétiques (IHU) Hôpital Necker - Enfants Malades [AP-HP] Rockefeller University [New York] Howard Hughes Medical Institute Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Hôpital Necker - Enfants Malades [AP-HP] Paris-Centre de Recherche Cardiovasculaire Institut National de la Santé et de la Recherche Médicale UFR Médecine [Santé] - Université Paris Cité Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre]
• Publié dans Frontiers in Immunology le 25/10/2020

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Résumé : Background The clinical outcome of COVID-19 pneumonia is highly variable. Few biological predictive factors have been identified. Genetic and immunological studies suggest that type 1 interferons (IFN) are essential to control SARS-CoV-2 infection. Objective To study the link between change in blood IFN-α2 level and plasma SARS-Cov2 viral load over time and subsequent death in patients with severe and critical COVID-19. Methods One hundred and forty patients from the CORIMUNO-19 cohort hospitalized with severe or critical COVID-19 pneumonia, all requiring oxygen or ventilation, were prospectively studied. Blood IFN-α2 was evaluated using the Single Molecule Array technology. Anti-IFN-α2 auto-Abs were determined with a reporter luciferase activity. Plasma SARS-Cov2 viral load was measured using droplet digital PCR targeting the Nucleocapsid gene of the SARS-CoV-2 positive-strand RNA genome. Results Although the percentage of plasmacytoid dendritic cells was low, the blood IFN-α2 level was higher in patients than in healthy controls and was correlated to SARS-CoV-2 plasma viral load at entry. Neutralizing anti-IFN-α2 auto-antibodies were detected in 5% of patients, associated with a lower baseline level of blood IFN-α2. A longitudinal analysis found that a more rapid decline of blood IFN-α2 was observed in fatal versus surviving patients: mortality HR=3.15 (95% CI 1.14–8.66) in rapid versus slow decliners. Likewise, a high level of plasma SARS-CoV-2 RNA was associated with death risk in patients with severe COVID-19. Conclusion These findings could suggest an interest in evaluating type 1 IFN treatment in patients with severe COVID-19 and type 1 IFN decline, eventually combined with anti-inflammatory drugs. Clinical trial registration https://clinicaltrials.gov , identifiers NCT04324073, NCT04331808, NCT04341584.

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Fichiers liés : fimmu-14-1250214.pdf

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 20/11/2023
• Auteurs : Aleksandar BlagojevicPatricia BaldrichMarlene SchiaffiniEsther LechnerNicolas BaumbergerPhilippe HammannTaline ElmayanDamien GarciaHervé VaucheretBlake MeyersPascal Genschik
• Organismes : Institut de Biologie Moléculaire des Plantes Donald Danforth Plant Science Center Institut de Biologie Moléculaire des Plantes Institut de Biologie Moléculaire des Plantes Institut de Biologie Moléculaire des Plantes Plateforme Protéomique Strasbourg – Esplanade Institut Jean-Pierre Bourgin - Sciences du végétal Institut de Biologie Moléculaire des Plantes Institut Jean-Pierre Bourgin - Sciences du végétal Donald Danforth Plant Science Center Institut de Biologie Moléculaire des Plantes

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Résumé : SUMMARY In Arabidopsis thaliana , ARGONAUTE1 (AGO1) plays a central role in microRNA (miRNA) and small interfering RNA (siRNA)-mediated silencing. Nuclear AGO1 is loaded with miRNAs and exported to the cytosol where it associates to the rough ER to conduct miRNA-mediated translational repression, mRNA cleavage and biogenesis of phased siRNAs. These latter, as well as other cytosolic siRNAs, are loaded into cytosolic AGO1, but in which compartment this happens is not known. Moreover, the effect of stress on AGO1 localization is still unclear. Here, we show that a 37°C heat stress (HS) promotes AGO1 protein accumulation in cytosolic condensates where it co-localizes with components of siRNA bodies and of stress granules (SGs). AGO1 contains a prion-like domain in its poorly characterized N-terminal Poly-Q domain, which, is sufficient to undergo phase separation, independent of the presence or absence of SGS3. HS only moderately affects the small RNA repertoire, the loading of AGO1 by miRNAs and the signatures of target cleavage, suggesting that its localization in condensates protects AGO1 rather than promotes or impairs its activity in reprograming gene expressing during stress. Collectively, our work shed new light on the impact of high temperature on a main effector of RNA silencing in plants.

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