Philippe JEAN-PIERRE

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 20/11/2023
• Auteurs : Aleksandar BlagojevicPatricia BaldrichMarlene SchiaffiniEsther LechnerNicolas BaumbergerPhilippe HammannTaline ElmayanDamien GarciaHervé VaucheretBlake MeyersPascal Genschik
• Organismes : Institut de Biologie Moléculaire des Plantes Donald Danforth Plant Science Center Institut de Biologie Moléculaire des Plantes Institut de Biologie Moléculaire des Plantes Institut de Biologie Moléculaire des Plantes Plateforme Protéomique Strasbourg – Esplanade Institut Jean-Pierre Bourgin - Sciences du végétal Institut de Biologie Moléculaire des Plantes Institut Jean-Pierre Bourgin - Sciences du végétal Donald Danforth Plant Science Center Institut de Biologie Moléculaire des Plantes

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Résumé : SUMMARY In Arabidopsis thaliana , ARGONAUTE1 (AGO1) plays a central role in microRNA (miRNA) and small interfering RNA (siRNA)-mediated silencing. Nuclear AGO1 is loaded with miRNAs and exported to the cytosol where it associates to the rough ER to conduct miRNA-mediated translational repression, mRNA cleavage and biogenesis of phased siRNAs. These latter, as well as other cytosolic siRNAs, are loaded into cytosolic AGO1, but in which compartment this happens is not known. Moreover, the effect of stress on AGO1 localization is still unclear. Here, we show that a 37°C heat stress (HS) promotes AGO1 protein accumulation in cytosolic condensates where it co-localizes with components of siRNA bodies and of stress granules (SGs). AGO1 contains a prion-like domain in its poorly characterized N-terminal Poly-Q domain, which, is sufficient to undergo phase separation, independent of the presence or absence of SGS3. HS only moderately affects the small RNA repertoire, the loading of AGO1 by miRNAs and the signatures of target cleavage, suggesting that its localization in condensates protects AGO1 rather than promotes or impairs its activity in reprograming gene expressing during stress. Collectively, our work shed new light on the impact of high temperature on a main effector of RNA silencing in plants.

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• Type de publi. : Article dans une revue
• Date de publi. : 19/11/2023
• Auteurs : Richard Sousa da SilvaEva BreuerSadhana ShankarShoji KawakatsuWacław HołówkoJoão Santos CoelhoHeithem JeddouTeiichi SugiuraMohammed GhallabDoris da SilvaGenki WatanabeFlorin BoteaNozomu SakaiPietro AddeoStylianos TzedakisFabian BartschKaja BalcerChetana LimFabien WereyVictor Lopez-LopezLuciana Peralta MonteroRodrigo Sanchez ClariaJennifer LeitingNeeta VachharajaniEve HoppingOrlando TorresSatoshi HiranoDaan AndelJeroen HagendoornAlicja PsicaMatteo RavaioliKeun Soon AhnTim ReeseLeonardo MontesGanesh GunasekaranCándido AlcázarJin Hong LimMuhammad HaroonQian LuAntonio CastaldiTatsuya OrimoBeat MoeckliTeresa AbadíaLuis RuffoloJosefina Dib HasanFrancesca RattiEmmanuele KauffmannRoeland de WildeWojciech PolakUgo BoggiLuca AldrighettiLucas MccormackRoberto Hernandez-AlejandroAlejandro SerrabloChristian TosoAkinobu TaketomiJean GugenheimJiahong DongFaisal HanifJoon Seong ParkJosé RamiaMyron SchwartzDiego RamischMichelle de OliveiraKarl OldhaferKoo Jeong KangMatteo CesconPeter LodgeInne RinkesTakehiro NojiJohn-Edwin ThomsonSu Kah GohWilliam ChapmanSean ClearyJuan PekoljJean-Marc RégimbeauOlivier ScattonStéphanie TruantHauke LangDavid FuksPhilippe BachellierMasayuki OhtsukaIrinel PopescuKiyoshi HasegawaMickaël LesurtelRené AdamDaniel CherquiKatsuhiko UesakaKarim BoudjemaHugo Pinto-MarquesMichał GrątHenrik PetrowskyTomoki EbataAndreas PrachaliasRicardo Robles-CamposPierre-Alain Clavien
• Organismes : University hospital of Zurich [Zurich] University hospital of Zurich [Zurich] King's College Hospital Nagoya City University [Nagoya, Japan] Warszawski Uniwersytet Medyczny [Polska] = Medical University of Warsaw [Poland] = Université de Médecine de Varsovie [Pologne] Centro Hospitalar Universitário Lisboa Central Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Shizuoka Cancer Center Hospital Centre Hépato-Biliaire [Hôpital Paul Brousse] Hôpital Beaujon [AP-HP] The University of Tokyo Fundeni Clinical Institute = Institutul Clinic Fundeni [Bucarest, Roumanie] Chiba University Hospital Pôle des Pathologies Digestives Hépatiques et Transplantation [Hôpital Hautepierre-Strasbourg] The University of Tokyo Centre de Recherche des Cordeliers Health data- and model- driven Knowledge Acquisition Hôpital Cochin [AP-HP] Lille économie management - UMR 9221 Centre Hospitalier Régional Universitaire [CHU Lille] CHU Pitié-Salpêtrière [AP-HP] Chirurgie digestive [CHU Amiens] Instituto Tecnológico de Tijuana = Tijuana Institute of Technology [Tijuana] Hospital Italiano de Buenos Aires Hospital Italiano de Buenos Aires Mayo Clinic Washington University School of Medicine [Saint Louis, MO] Royal Adelaide Hospital [Adelaide Australia] Presidente Dutra Hospital [São Luís] Hokkaido University Hospital [Sapporo] University Medical Center [Utrecht] University Medical Center [Utrecht] St James's University Hospital Istituti di Ricovero e Cura a Carattere Scientifico Keimyung University Semmelweis University of Medicine [Budapest] University Hospital [Buenos Aires] Icahn School of Medicine at Mount Sinai [New York] General University Hospital of Alicante Yonsei University Bahria International Hospital Orchard [Lahore] Qing hua da xue = Tsinghua University = Université Tsinghoua [Beijing] CHU Nice [Cimiez] Hokkaido University Hospital [Sapporo] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Hospital Universitario Miguel Servet University of Rochester [USA] Hospital Alemán [Buenos Aires] IRCCS Ospedale San Raffaele [Milan, Italy] University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie] Erasmus University Medical Center [Rotterdam] Erasmus University Medical Center [Rotterdam] University of Pisa [Italy] = Università di Pisa [Italia] = Université de Pise [Italie] IRCCS Ospedale San Raffaele [Milan, Italy] Hospital Alemán [Buenos Aires] University of Rochester [USA] Hospital Universitario Miguel Servet Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Hokkaido University Hospital [Sapporo] Hôpital Cimiez [Nice] Qing hua da xue = Tsinghua University = Université Tsinghoua [Beijing] Bahria International Hospital Orchard [Lahore] Yonsei University General University Hospital of Alicante Icahn School of Medicine at Mount Sinai [New York] Favaloro Foundation [Buenos Aires] University hospital of Zurich [Zurich] Semmelweis University of Medicine [Budapest] Keimyung University IRCCS Azienda Ospedaliero-Universitaria di Bologna Leeds Teaching Hospitals NHS Trust University Medical Center [Utrecht] Hokkaido University of Science Royal Adelaide Hospital [Adelaide Australia] Royal Adelaide Hospital [Adelaide Australia] Washington University in Saint Louis Mayo Clinic [Rochester] Hospital Italiano de Buenos Aires CHU Amiens-Picardie Cytométrie Pitié-Salpêtrière Centre Hospitalier Régional Universitaire [CHU Lille] University Medical Center [Mainz] Hôpital Cochin [AP-HP] Université de Strasbourg Chiba University Hospital Fundeni Clinical Institute = Institutul Clinic Fundeni [Bucarest, Roumanie] The University of Tokyo Hôpital Beaujon [AP-HP] Hôpital Paul Brousse Hôpital Paul Brousse Shizuoka Cancer Center Hospital Hôpital Sud [CHU Rennes] Centro Hospitalar Universitário Lisboa Central Warszawski Uniwersytet Medyczny [Polska] = Medical University of Warsaw [Poland] = Université de Médecine de Varsovie [Pologne] University hospital of Zurich [Zurich] Nagoya University King's College Hospital Instituto Murciano de Investigación Biosanitaria Pascual Parrilla University hospital of Zurich [Zurich]
• Publié dans Annals of Surgery le 26/10/2020

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Résumé : Objective: This study aims at establishing benchmark values for best achievable outcomes following open major anatomic hepatectomy for liver tumors of all dignities. Background: Outcomes after open major hepatectomies vary widely lacking reference values for comparisons among centers, indications, types of resections, and minimally invasive procedures. Methods: A standard benchmark methodology was used covering consecutive patients, who underwent open major anatomic hepatectomy from 44 high-volume liver centers from 5 continents over a 5-year period (2016–2020). Benchmark cases were low-risk non-cirrhotic patients without significant comorbidities treated in high-volume centers (≥30 major liver resections/year). Benchmark values were set at the 75th percentile of median values of all centers. Minimum follow-up period was 1 year in each patient. Results: Of 8044 patients, 2908 (36%) qualified as benchmark (low-risk) cases. Benchmark cutoffs for all indications include R0 resection ≥78%; liver failure (grade B/C) ≤10%; bile leak (grade B/C) ≤18%; complications ≥grade 3 and CCI ® ≤46% and ≤9 at 3 months, respectively. Benchmark values differed significantly between malignant and benign conditions so that reference values must be adjusted accordingly. Extended right hepatectomy (H1, 4-8 or H4-8) disclosed a higher cutoff for liver failure, while extended left (H1-5,8 or H2-5,8) were associated with higher cutoffs for bile leaks, but had superior oncologic outcomes, when compared to formal left hepatectomy (H1-4 or H2-4). The minimal follow-up for a conclusive outcome evaluation following open anatomic major resection must be 3 months. Conclusion: These new benchmark cutoffs for open major hepatectomy provide a powerful tool to convincingly evaluate other approaches including parenchymal-sparing procedures, laparoscopic/robotic approaches, and alternative treatments, such as ablation therapy, irradiation, or novel chemotherapy regimens.

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• Type de publi. : Pré-publication, Document de travail
• Date de publi. : 17/11/2023
• Auteurs : Pascale AmansAnne-Charlotte BaudequinPhilippe BerthetThomas BerthelierCorinne BonnetFlorent ChampyCamille DumatAurélie DupriezArthur FloquetPierre FrequelinClara Le DuffQian LIUChristel LutzMatthieu MambriniIsabelle MalfantMarie-Christine MiquelFranck PlourabouéGiorgia RicciNicolas RouxSaloum SakhoTitouan Tyack
• Organismes : Laboratoire de Gestion et des Transitions Organisationnelles Communauté d'universités et établissements de Toulouse Institut de Mathématiques de Toulouse UMR5219 Communauté d'universités et établissements de Toulouse Patrimoine, Littérature, Histoire Laboratoire Interdisciplinaire Solidarités, Sociétés, Territoires Dynamiques et écologie des paysages agriforestiers Communauté d'universités et établissements de Toulouse CoMputational imagINg anD viSion Institut Clément Ader Communauté d'universités et établissements de Toulouse Communauté d'universités et établissements de Toulouse Institut de pharmacologie et de biologie structurale Laboratoire de Physique Théorique Fermions Fortement Corrélés (LPT) Laboratoire de chimie de coordination Centre de Recherches sur la Cognition Animale - UMR5169 Institut de mécanique des fluides de Toulouse Communauté d'universités et établissements de Toulouse Institut National des Postes et Télécommunications [Rabat] Communauté d'universités et établissements de Toulouse Communauté d'universités et établissements de Toulouse

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Résumé : Relever les défis actuels, qu’ils soient climatiques, sanitaires, énergétiques, numériques ou encore alimentaires, nécessite de mobiliser tous les champs de la connaissance. La complexité des problèmes auxquels nous sommes confrontés se prête mal à l’expertise mono-disciplinaire : c’est seulement par le développement d’une approche plus globale et intégrée, nommée « intersciences », que des réflexions et solutions innovantes pourront émerger. Pour s'y préparer, de nouveaux instruments sont à inventer au carrefour de l'enseignement supérieur, de la recherche et des enjeux sociétaux. Ces premières Journées Intersciences de Toulouse (JIT 2023) ont consisté en une articulation entre des conférences de référence et des tables rondes regroupant des spécialistes de la pratique de l’intersciences en termes de recherche, enseignement et fabrique des métiers de demain.

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Fichiers liés : HAL CR JIT nov2023 version12 2024oct15_defi.pdf

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• Type de publi. : Rapport
• Date de publi. : 17/11/2023
• Auteurs : Jean-Claude GrégoireMartin GodefroidHervé JactelRaphaëlle MouttetCecile RobinAlain RoquesThomas Le BourgeoisPhilippe Castagnone-SerenoThierry CandresseNicolas DesneuxSandrine EveillardFlorence FontainePascal GentitLucia GuerinBruno HostachyEleni KazakouChristophe Le MayEric LombaertDavid MakowskiCharles ManceauArnaud MontyMaria Navajas NavarroAurélien SalleFrédéric SuffertStéphan SteyerPierre-Yves TeycheneyEric VerdinFrançois VerheggenEmmanuel GachetXavier Tassus
• Organismes : Université libre de Bruxelles = Free University of Brussels Centre de Biologie pour la Gestion des Populations Biodiversité, Gènes & Communautés Unité entomologie et plantes invasives Biodiversité, Gènes & Communautés Zoologie forestière Botanique et Modélisation de l'Architecture des Plantes et des Végétations Département Systèmes Biologiques Institut Sophia Agrobiotech Biologie du fruit et pathologie Institut Sophia Agrobiotech Biologie du fruit et pathologie Résistance Induite et Bioprotection des Plantes UMR INRAE 1488 RIBP Laboratoire de santé des végétaux Ecole Nationale Supérieure des Sciences Agronomiques de Bordeaux-Aquitaine ANSES-LSV Institut Agro - Montpellier SupAgro Institut de Génétique, Environnement et Protection des Plantes Institut Sophia Agrobiotech Mathématiques et Informatique Appliquées Laboratoire de santé des végétaux Gembloux Agro-Bio Tech [Faculté universitaire des sciences agronomiques de Gembloux] Centre de Biologie pour la Gestion des Populations Université d'Orléans BIOlogie et GEstion des Risques en agriculture Centre wallon de Recherches Agronomiques [Belgique] = Walloon Agricultural Research Centre [Belgium] Peuplements végétaux et bioagresseurs en milieu tropical Département Systèmes Biologiques Unité de Pathologie Végétale Université de Liège = University of Liège = Universiteit van Luik = Universität Lüttich Direction de l'Evaluation des Risques Direction de l'Evaluation des Risques

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Résumé : Dans le cadre de la surveillance des organismes réglementés ou émergents (SORE), un dispositif de piégeage a été déployé par la DGAL en 2021 avec l’appui de l’INRAE et de l’ONF. L’objectif de ce dispositif est d’effectuer une surveillance passive dans les sites d’entrée potentiels (ports, aéroports, marchés d’intérêt national (MIN) des organismes réglementés ou émergents (SORE). Ce piégeage est qualifié de « large spectre » car il peut concerner plusieurs filières de production suivies dans le cadre de la SORE (forêts, jardins et espaces verts et infrastructures (JEVI), arboriculture fruitière) en ciblant cependant majoritairement les insectes coléoptères des ligneux. Les principes de la surveillance mise en œuvre s’appuient sur les résultats précédemment acquis dans le cadre du projet PORTRAP, utilisant des pièges génériques multi-composés pour la détection précoce d’insectes exotiques xylophages dans les sites potentiels d’entrée sur le territoire national. Les pièges ont été disposés sur 13 sites (7 ports maritimes, 1 port fluvial, 4 aéroports et 1 marché national) dispersés sur le territoire (France continentale). Au total 9279 individus appartenant à 110 espèces différentes ont été capturés. Aucune espèce d’insecte de quarantaine prioritaire n’a été piégée. En revanche, la présence d’individus appartenant à 8 espèces de coléoptères exotiques, a priori non répandues sur notre territoire, des familles Cerambycidae et Curculionidae (sous-familles des Scolytinae et Platypodinae) a été relevée. Les 8 espèces d’insectes exotiques sont les suivantes : Cerambycidae : Cordylomera spinicornis (Fabricius, 1775), Trichoferus campestris (Faldermann, 1835), Xylotrechus chinensis (Chevrolat, 1852), Xylotrechus stebbingi (Gahan, 1906) ; Curculionidae : Amasa sp. near truncata, Euplatypus hintzii (Schaufuss, 1897), Euplatypus parallelus (Fabricius, 1801), Xyleborus affinis Eichhoff, 1868. Ainsi, il est demandé la réalisation d’une catégorisation des 8 espèces d’insectes exotiques en utilisant les critères de risque listés ci-dessous, afin de déterminer leur nuisibilité et de prioriser sur cette base la réalisation d’analyses de risque portant sur ces insectes.

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• Type de publi. : Article dans une revue
• Date de publi. : 17/11/2023
• Auteurs : Raphaël DegraveJuliette MurrisAnaïs Charles-NelsonOlivier HermineRaphaël PorcherPhilippe RavaudXavier MariettePierre-Louis TharauxMatthieu Resche-RigonOlivier SanchezSandrine KatsahianJean-Benoît Arlet
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche des Cordeliers Health data- and model- driven Knowledge Acquisition Hôpital Européen Georges Pompidou [APHP] Hôpital Necker - Enfants Malades [AP-HP] Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre] Immunologie des maladies virales, auto-immunes, hématologiques et bactériennes Paris-Centre de Recherche Cardiovasculaire Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Hôpital Européen Georges Pompidou [APHP] Health data- and model- driven Knowledge Acquisition CIC - HEGP Hôpital Européen Georges Pompidou [APHP] Centre de Recherche des Cordeliers Hôpital Européen Georges Pompidou [APHP]
• Publié dans Postgraduate Medical Journal le 02/11/2020

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Résumé : Abstract Purpose To assess risk factors for arterial and venous thromboses (AVT) in patients hospitalized in general wards for COVID-19 pneumonia and requiring oxygen therapy. Methods Our study was based on three randomized studies conducted as part of the CORIMUNO-19 platform in France between 27 March and 26 April 2020. Adult inpatients with COVID-19 pneumonia requiring at least 3 l/min of oxygen but not ventilation were randomized to receive standard care alone or standard care plus biologics. Patients were followed up for 3 months, and adverse events were documented. Risk factor for AVT and bleeding was identified by analyzing clinical, laboratory, and treatment data at baseline among the 315 patients with complete datasets. A Fine and Gray model was used to take account of competing events. Results During the 3-month follow-up period, 39 AVT occurred in 38 (10%) of the 388 patients: 26 deep vein thromboses and/or pulmonary embolisms in 25 (6%) patients, and 14 arterial thrombotic events in 13 (3%) patients. A history of diabetes at inclusion [sHR (95% CI) = 2.65 (1.19–5.91), P = .017] and the C-reactive protein (CRP) level (sHR = 1 [1–1.01], P = .049) were significantly associated with an elevated risk of thrombosis. Obesity was not associated with a higher risk of thrombosis (sHR = 1.01 [0.4–2.57], P = .98). The CRP level and diabetes were not risk factors for hemorrhage. Conclusion Among patients hospitalized in general wards for COVID-19 pneumonia during the first wave of the epidemic, diabetes (but not obesity) and a high CRP level were risk factors for AVT. The use of higher doses of anticoagulant in these high-risk patients could be considered.

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• Type de publi. : Article dans une revue
• Date de publi. : 16/11/2023
• Auteurs : Quynh Bach Thi NhuLinh Le Thi ThuyHong Thi NguyenBinh Nguyen ThanhDelphine RapoudCatherine QuilletHong Thi TranR. ValloThanh Nham Thi TuyetLaurent MichelLaurence WeissPhilippe Van de PerreVinh Vu HaiNicolas NagotOanh Khuat Thi HaiDon Des JarlaisHuong Duong ThiPham Minh KhueDidier LaureillardJean-Pierre Moles
• Organismes : Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Immunologie humaine, physiopathologie & immunothérapie Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections Pathogenesis and Control of Chronic and Emerging Infections
• Publié dans Diagnostics le 01/11/2020

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Résumé : The desired performance of nucleic acid testing (NAT) may vary if used for disease diagnosis or for the evaluation of the therapeutic efficacy of a treatment, although in most cases, the same assay is used. However, these tests may not be affordable in many situations including in low/middle income countries that in response have developed domestic assays. Given the example of HCV NAT among people who inject drugs in Vietnam, we aimed at evaluating a domestic assay versus an FDA-and CE-approved assay. This cross-evaluation revealed that (i) the domestic assay had a poorer sensitivity with a threshold of detection above 10 4 IU/mL, and (ii) the FDA-approved assay had a percentage of false negative results close to 1%. Together, in the present study, the domestic assay had a performance compatible with diagnosis purposes (given that this population was 70% HCV seropositive) but not compatible with HCV treatment monitoring (given that treatment failures are rare and the observed viremia frequently below the threshold of detection). This study highlights the need for a proper evaluation of HCV RNA domestic assays in order to efficiently contribute to the WHO HCV elimination target by 2030.

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Fichiers liés : diagnostics-13-03456.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 16/11/2023
• Auteurs : Elise LaruelleJean-Christophe PalauquiPhilippe AndreyAlain Trubuil
• Organismes : Institut Jean-Pierre Bourgin - Sciences du végétal Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] Sainsbury Laboratory Cambridge University Institut Jean-Pierre Bourgin - Sciences du végétal Institut Jean-Pierre Bourgin - Sciences du végétal Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas]
• Publié dans Plant Methods le 27/10/2020

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Résumé : Background With the emergence of deep-learning methods, tools are needed to capture and standardize image annotations made by experimentalists. In developmental biology, cell lineages are generally reconstructed from timelapse data. However, some tissues need to be fixed to be accessible or to improve the staining. In this case, classical software do not offer the possibility of generating any lineage. Because of their rigid cell walls, plants present the advantage of keeping traces of the cell division history over successive generations in the cell patterns. To record this information despite having only a static image, dedicated tools are required. Results We developed an interface to assist users in the building and editing of a lineage tree from a 3D labeled image. Each cell within the tree can be tagged. From the created tree, cells of a sub-tree or cells sharing the same tag can be extracted. The tree can be exported in a format compatible with dedicated software for advanced graph visualization and manipulation.

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Fichiers liés : laruelle2023-TreeJ.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 15/11/2023
• Auteurs : Philippe Saint-PierreNicolas Savy
• Organismes : Institut de Mathématiques de Toulouse UMR5219 Institut de Mathématiques de Toulouse UMR5219
• Publié dans The international journal of biostatistics le 27/10/2020

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Résumé : Abstract Simulation studies are promising in medical research in particular to improve drug development. For instance, one can aim to develop In Silico Clinical Trial in order to challenge trial’s design parameters in terms of feasibility and probability of success of the trial. Approaches based on agent-based models draw on a particularly useful framework to simulate patients evolution. In this paper, an approach based on agent-based modeling is described and discussed in the context of medical research. An R-vine copula model is used to represent the multivariate distribution of the data. A baseline data cohort can then be simulated and execution models can be developed to simulate the evolution of patients. R-vine copula models are very flexible tools which allow researchers to consider different marginal distributions than the ones observed in the data. It is then possible to perform data augmentation to explore a new population by simulating baseline data which are slightly different than those of the original population. A simulation study illustrates the efficiency of copula modeling to generate data according to specific marginal distributions but also highlights difficulties inherent to data augmentation.

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• Type de publi. : Article dans une revue
• Date de publi. : 15/11/2023
• Auteurs : Romain DemeulemeesterNicolas SavyPascale GrosclaudeNadège CostaPhilippe Saint-Pierre
• Organismes : Centre Hospitalier Universitaire de Toulouse Institut de Mathématiques de Toulouse UMR5219 Oncopole Claudius Regaud Institut Universitaire du Cancer de Toulouse - Oncopole Equipe EQUITY (CERPOP) Centre d'Epidémiologie et de Recherche en santé des POPulations Institut de Mathématiques de Toulouse UMR5219 Institut Universitaire de Technologie - Paul Sabatier
• Publié dans The international journal of biostatistics le 27/10/2020

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Résumé : Although they remain little used in the field of Health Care Economics, Agent Based Models (ABM) are potentially powerful decision-making tools that open up great prospects. The reasons for this lack of popularity are essentially to be found in a methodology that should be further clarified. This article hence aims to illustrate the methodology by means of two applications to medical examples. The first example of ABM illustrates the construction of a Baseline Data Cohort by means of a Virtual Baseline Generator. The aim is to describe the prevalence of thyroid cancer in the French population over the long term according to different scenarios of evolution of this population. The second study considers a setting where the Baseline Data Cohort is an established cohort of (real) patients: the EVATHYR cohort. The aim of the ABM is to describe the long-term costs associated with different scenarios of thyroid cancer management. The results are evaluated using several simulation runs in order to observe the variability of simulations and to derive prediction intervals. The ABM approach is very flexible since several sources of data can be involved and a large variety of simulation models can be calibrated to generate observations according to different evolution scenarios.

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• Type de publi. : Article dans une revue
• Date de publi. : 14/11/2023
• Auteurs : Philipp KlossMaximilian LindholzAnnette MilnikÉlie AzoulayMaurizio CecconiGiuseppe CiterioThomas de CorteFrantisek DuskaLaura GalarzaMassimiliano GrecoArmand GirbesJozef KeseciogluJohannes MellinghoffMarlies OstermannMariangela PellegriniJean-Louis TeboulJan de WaeleAdrian WongStefan SchallerBuenos AiresAlicia GiraPhilipp EllerTarikul HamidInjamam Ull HaqueWim de BuyserAntonella CudiaDaniel de BackerPierre FoulonVincent CollinJolien van HeckeElisabeth de WaeleClaire van MalderenJean-Baptiste MeslandPatrick BistonMichael PiagnerelliLionel HaentjensNicolas de SchryverJan van LeemputPhilippe VanhovePierre BulpaViktoria IlievaDavid KatzAlexandra BinnieAnna GeageaFernando TirapeguiGustavo LagoJerónimo GrafRodrigo Perez-AraosPatricio VargasFelipe MartinezEduardo LabarcaDaniel Molano FrancoDaniela Parra-TanouxDavid YepesAhmed HammoudaOmar ElmandouhAhmed AzzamAliae Mohamed HusseinIslam GalalAhmed AwadMohammed AzabMaged AbdallaHebatallah AssalMostafa AlfishawySherief GhozySamar TharwatAbdullah EldalyAnneli EllerveeVeronika ReinhardAnne ChrismentChrystelle PoyatJulio BadieFernando Berdaguer FerrariBjörn WeissClara SchellenbergJulius GrunowMarco LorenzStefan SchallerPeter SpiethMarc BotaFalk FichtnerKristina FuestTobias LahmerJohannes HerrmannPatrick MeybohmNikolaos MarkouGeorgia VasileiadouEvangelia ChrysanthopoulouPanagiotis PapamichalisIoanna SoultatiSameer JogKushal KalvitSheila Nainan MyatraIvan KrupaAisa TharwatAlistair NicholAine MccarthyAta MahmoodpoorTommaso TonettiPaolo IsoniSavino SpadaroCarlo Alberto VoltaLucia MirabellaAlberto NotoGaetano FlorioAmedeo GuzzardellaChiara PaleariFederica BaccanelliMarzia SaviMassimo AntonelliGennaro de PascaleBarbara VaccariniGiorgia MontrucchioGabriele SalesKatia DonadelloLeonardo GottinMarta NizzeroEnrico PolatiSilvia de RosaDemet SulemanjiAbdurraouf AbusalamaMuhammed ElhadiMontelongo Felipe De JesusDaniel Rodriguez GonzalezVictor Hugo Madrigal RoblesNancy CanedoAlejandro Esquivel ChavezTarek DendaneBart GradyBen de JongEveline van der HeidenPatrick ThoralBas van den BogaardPeter SpronkSefanja AchterbergMelanie GroeneveldRalph SoCalvin de WijsHarm ScholtenAlbertus BeishuizenAlexander CornetAuke ReidingaHetty KranenRoos MensinkSylvia den BoerMarcel de GrootOliver BeckCarina BethlehemBas van BusselTim FrenzelCelestine de JongRob WiltingJannet Mehagnoul-SchipperDatonye AlasiaAshok KumarAhad QayyumMuhammad RanaMustafa Abu JayyabRosario Quispe SierraAaron Mark HernandezLúcia TabordaMónica AnselmoTiago RamiresCatarina SilvaCarolina RorizRui MoraisPedro PóvoaPatricia PatricioAndré PintoMaria Lurdes SantosVasco CostaPedro CunhaCelina GonçalvesSandra NunesJoão CamõesDiana AdriãoAna OliveiraAli OmraniMuna Al MaslamaniAbdurrahmaan Suei ElbuzidiBara Mahmoud Al QudahAbdel Rauof AkkariMohamed AlkhattebAnas BaiouAhmed HusainMohamed AlwraidatIbrahim Abdulsalam SaifDana BakdachAmna AhmedMohamed AleefAwadh BintaherCristina PetrisorEvgeniy PopovKsenia PopovaMariia DementienkoBoris TeplykhAlexey PyregovLiubov DavydovaBelskii VladislavElena NeporadaIvan ZverevSvetlana MeshchaninovaDmitry SokolovElena GavrilovaIrina ShlykIgor PoliakovMarina VlasovaOhoud AljuhaniAmina AlkhalafFelwa Bin HumaidYaseen ArabiAhmed KuhailOmar ElrabiMadihah GhannamAmit KansalVui Kian HoJensen NgRaquel Rodrígez GarcíaXiana Taboada FragaMª del Pilar García-BonilloAntonio Padilla-SerranoMarta Martin CuadradoCarlos FerrandoIgnacio Catalan-MonzonFernando Frutos-VivarJorge JimenezCarmen Rodríguez-SolisEnric Franquesa-GonzalezGuillermo Pérez AcostaLuciano Santana CabreraJuan Pablo Aviles ParraFrancisco Muñoyerro GonzalezMaria Lorente del Carmen ConesaIgnacio Yago Martinez VarelaOrville Victoriano Baez PraviaMaria Cruz Martin DelgadoCarlos Munoz de CaboAna-Maria IoanCesar Perez-CalvoArnoldo SantosAne Abad-MotosJavier Ripolles-MelchorBelén Civantos MartinSantiago Yus TeruelJuan Higuera LucasAaron Blandino OrtizRaúl de Pablo SánchezJesús Emilio Barrueco-FrancioniLorena Forcelledo EspinaJosé Bonell-GoytisoloIñigo SalaverriaAntonia Socias MirEmilio Rodriguez-RuizVirginia Hidalgo ValverdePatricia Jimeno CuberoFrancisca Arbol LindeNieves Cruza LeganesJuan Maria RomeuPablo ConchaJosé Angel Berezo-GarciaVirginia FraileCristina Cuenca-RubioDavid Pérez-TorresAinhoa SerranoClara Martínez ValeroAndrea Ortiz SunerLeire LarrañagaNoemi LegaristiGerardo FerrignoSafa KhlafallaRosita Bihariesingh-SanchitFrank ZoernerJonathan GripKristina KilsandJohan MårtenssonJonas ÖsterlindMagnus von SethJohan BerkiusSamuele CerutiAndrea GlottaSeval IzdesIşıl Özkoçak TuranAhmet CosarBurcin HalacliNecla DereliMehmet YilmazTürkay AkbasGülseren ElaySelin EyüpoğluYelíz BílírKemal Tolga SaraçoğluEbru KayaAyca Sultan SahinPervin Korkmaz EkrenTuğçe MengiKezban Ozmen SunerYakup TomakAhmet ErogluAsad AlsabbahKatie HanlonKevin GervinSean McmahonSamantha HaganCaroline HigenbottamRandeep MullhiLottie PoultonTomasz TorlinskiAllen GarethNick TrumanGopal VijayakumarChris HallAlasdair JubbLenka CagovaNicola JonesSam GrahamNicole RobinAmanda CowtonAdrian DonnellyNatalia SingatullinaMelanie KentCarole BoulangerZoë CampbellElizabeth PotterNatalie DuricTamas SzakmanyOrinta KviatkovskeNandor MarczinCaroline EllisRajnish SahaChunda Sri-ChandanaJohn AllanLana MumeljHarish VenkateshVera Nina GotzAnthony CochraneBarbara FicialShruthi KambleNuttha LumlertgulChristopher OddySusan JainGiulia Beatrice CrapelliAikaterini VlachouDavid GoldenSweyn GarriochJeremy HenningGupta LoveleenaMiriam DaveyLina GrauslyteErika Salciute-SimeneMartin CookDanny BarlingPhil BroadhurstSarah PurvisMichael SpiveyBenjamin ShukerIrina GrecuDaniel HardingNatalia SingatullinaJames DeanNathan NielsenSama Al-BayatiMohammed Al-SadawiMariane CharronPeter StubenrauchJairo SantanillaCatherine WentowskiDorothea RosenbergerPolikseni EksarkoRandeep Jawa
• Organismes : Hopital Saint-Louis [AP-HP] Istituto Clinico Humanitas [Milan] Università degli Studi di Milano-Bicocca = University of Milano-Bicocca VU University Medical Center [Amsterdam] Guy's and St Thomas' Hospital [London] SMARRT Study ANZICS Clinical Trials Group Hedenstierna Laboratory, Department of Surgical Sciences Hôpital Bicêtre [GHU AP-HP. Université Paris-Saclay, Le Kremlin-Bicêtre] Hypertension pulmonaire : physiopathologie et innovation thérapeutique Groupe de recherche clinique CARMAS (Cardiovascular and Respiratory Manifestations of Acute lung injury and Sepsis) Hypertension pulmonaire : physiopathologie et innovation thérapeutique
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021).

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