Philippe JEAN-PIERRE

---

• Type de publi. :
• Date de publi. : 05/06/2023
• Auteurs : Maha KooliHenri-Pierre CharlesThaddée BricoutJean-Philippe NoelMaria Ramirez-CorralesBastien Giraud
• Organismes : Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes Laboratoire Fonctions Innovantes pour circuits Mixtes

---

Résumé : Computational SRAM (C-SRAM) is a new computing solution for Near-Memory Computing. It allows to perform operations inside or next to the memory without transferring data over the system bus, leading to significantly reducing energy consuption. Operations are realized on large vectors of data occupying the entire physical row of C-SRAM array, leading to high performance gains. This paper presents the C-SRAM solution as an integrated vector-processing unit to be used by a RISC-V processor as an energy-efficient and high performing co-processor. The proposed programming model of the C-SRAM is based on the system bus of a RISC-V processor.

---

Fichiers liés : Kooli82.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 05/06/2023
• Auteurs : Raphaël GarinPierre-Jean BouvetPhilippe ForjonelBeatrice Tomasi
• Organismes : Systèmes Embarqués, Acoustique et Télécommunications Systèmes Embarqués, Acoustique et Télécommunications Systèmes Embarqués, Acoustique et Télécommunications Norwegian Research Center

---

Résumé : Autonomous underwater vehicles localization is a challenging task due to the harsh environment of the underwater propagation channel. To reach accurate positioning, it is often required to use either a complex architecture or costly sensors. In this paper we provide the experimental results of a cost-effective technique combining underwater acoustic communication and localization through Doppler shift estimation that provides information on receiver relative speed. We consider a fixed anchor with known position transmitting regularly to a moving boat in water at a constant depth of 2 meters in a range up to 800 meters. Using an Extended Kalman filter, we compare standalone range measurements estimation with speed and range combined in the estimation filter. Experimental results demonstrate a consequent gain using speed computation associated with range measurement and a good accuracy on positioning results.

---

Fichiers liés : 2023101704-1.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 04/06/2023
• Auteurs : Constance DouwesGiovanni BindiAntoine CaillonPhilippe EslingJean-Pierre Briot
• Organismes : Sciences et Technologies de la Musique et du Son Sciences et Technologies de la Musique et du Son Sciences et Technologies de la Musique et du Son Sciences et Technologies de la Musique et du Son Institut de Recherche et Coordination Acoustique/Musique Universidade Federal do Estado do Rio de Janeiro Systèmes Multi-Agents

---

Résumé : In most scientific domains, the deep learning community has largely focused on the quality of deep generative models, resulting in highly accurate and successful solutions. However, this race for quality comes at a tremendous computational cost, which incurs vast energy consumption and greenhouse gas emissions. At the heart of this problem are the measures that we use as a scientific community to evaluate our work. In this paper, we suggest relying on a multi-objective measure based on Pareto optimality, which takes into account both the quality of the model and its energy consumption. By applying our measure on the current state-of-the-art in generative audio models, we show that it can drastically change the significance of the results. We believe that this type of metric can be widely used by the community to evaluate their work, while putting computational cost – and in fine energy consumption – in the spotlight of deep learning research.

---

Fichiers liés : _ICASSP_23__Is_Quality_Enough__Integrating_Energy_Consumption_in_a_Large_Scale_Evaluation_of_Neural_Audio_Synthesis_Models.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 04/06/2023
• Auteurs : Louise TarradeJean-Pierre ChevrotJean-Philippe Magué
• Organismes : Interactions, Corpus, Apprentissages, Représentations LInguistique et DIdactique des Langues Étrangères et Maternelles Institut universitaire de France Institut Rhône-Alpin des systèmes complexes Interactions, Corpus, Apprentissages, Représentations

---

Résumé : The study examines the diffusion of lexical innovations (new words) on Twitter between 2012 and 2019, seeking to determine whether the position of users within the social network influences the success or failure of the spread of these innovations. We identify lexical innovations that emerged during 2012-2014 and categorize them into "changes" that become widely adopted versus "buzz" words that fade out after a spike in usage. By comparing the network characteristics of users employing these innovations at each diffusion phase (innovation, propagation, stabilization/decline), the results show that: - The initial users (innovators) have a similar profile regardless of whether the innovation succeeds. -However, during the propagation phase, successful "changes" reach more central, prestigious users, unlike "buzz" words. - An innovation's fate can be predicted as early as the propagation phase based on the network profiles of its users. In conclusion, the position of speakers within the Twitter social network impacts the success of lexical innovation diffusion. Central, influential users are necessary for an innovation to take hold.

---

Fichiers liés : proposition_JLC_finale.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 04/06/2023
• Auteurs : Pierre DevelterJonathan BosseOlivier RabastePhilippe ForsterJean-Philippe Ovarlez
• Organismes : DEMR, ONERA, Université Paris Saclay [Palaiseau] Sondra, CentraleSupélec, Université Paris-Saclay DEMR, ONERA, Université Paris Saclay [Palaiseau] DEMR, ONERA, Université Paris Saclay [Palaiseau] Systèmes et Applications des Technologies de l'Information et de l'Energie DEMR, ONERA, Université Paris Saclay [Palaiseau] Sondra, CentraleSupélec, Université Paris-Saclay

---

Résumé : In the state-of-the-art, the Probability of False Alarm (P F A)threshold relationship for the popular Matched Filter (MF) is often derived assuming that unknown non-linear parameters lie on a grid. However, these parameters vary continuously in practice. This is known as the off-grid case. In this article, an asymptotic P F A-threshold relationship for the popular Matched Filter is derived in the off-grid case under complex white Gaussian noise hypothesis using expected Euler characteristics. This asymptotic relationship fits very well with corresponding Monte-Carlo trials in the moderate to low P F A regime.

---

Fichiers liés : ICASSP2023.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2023
• Auteurs : Tania MarxLuc-Marie JolyAnne-Laure ParmentierJean-Baptiste PretalliMarc PuyraveauJean-Claude MeuriceJeannot SchmidtOlivier TiffetGilbert FerrettiDominique LauqueDidier HonnartFaraj Al FreijatAlain Eric DubartRomain Genre GrandpierreAlain ViallonDominique PerduPierre Marie RoyToufiq El CadiNathalie BronetGrégory DuncanGilles CardotPhilippe LestavelFrédéric MaunyThibaut Desmettre
• Organismes : Laboratoire de Psychologie Sociale et Cognitive CHU Clermont-Ferrand
• Publié dans American Journal of Respiratory and Critical Care Medicine le 26/10/2020

---

Résumé : Rationale: Management of first episodes of primary spontaneous pneumothorax remains the subject of debate. Objectives: To determine whether first-line simple aspiration is noninferior to first-line chest tube drainage for lung expansion in patients with complete primary spontaneous pneumothorax. Methods: We conducted a prospective, open-label, randomized noninferiority trial. Adults aged 18–50 years with complete primary spontaneous pneumothorax (total separation of the lung from the chest wall), recruited at 31 French hospitals from 2009 to 2015, received simple aspiration (n = 200) or chest tube drainage (n = 202) as first-line treatment. The primary outcome was pulmonary expansion 24 hours after the procedure. Secondary outcomes were tolerance of treatment, occurrence of adverse events, and recurrence of pneumothorax within 1 year. Substantial discordance in the numerical inputs used for trial planning and the actual trial rates of the primary outcome resulted in a reevaluation of the trial analysis plan. Measurement and Main Results: Treatment failure occurred in 29% in the aspiration group and 18% in the chest tube drainage group (difference in failure rate, 0.113; 95% confidence interval [CI], 0.026–0.200). The aspiration group experienced less pain overall (mean difference, −1.4; 95% CI, −1.89, −0.91), less pain limiting breathing (frequency difference, −0.18; 95% CI, −0.27, −0.09), and less kinking of the device (frequency difference, −0.05; 95% CI, −0.09, −0.01). Recurrence of pneumothorax was 20% in this group versus 27% in the drainage group (frequency difference, −0.07; 95% CI, −0.16, +0.02). Conclusions: First-line management of complete primary spontaneous pneumothorax with simple aspiration had a higher failure rate than chest tube drainage but was better tolerated with fewer adverse events.

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2023
• Auteurs : Walid KhroufDario SaracinoBenoit RuchetonMarion HouotFabienne ClotDaisy RinaldiJoana VitorMarie HuynhEvelyne HengDimitri SchlemmerFlorence PasquierVincent DeramecourtSophie AuriacombeCarole AzuarRichard LevyStephanie BomboisClaire Boutoleau-BretonnièreJérémie ParienteMira DidicDavid WallonFrederique FluchereStephane AuvinImen Ben YounesYann NadjarAlexis BriceBruno DuboisDominique Bonnefont-RousselotIsabelle Le BerFoudil LamariSerge BelliardFrederic BlancMathieu CeccaldiPhilippe CouratierFrederique Etcharry-BouyxMaïté FormaglioVeronique GolfierDidier HannequinLucette LacomblezJulien LagardeBernard-Francois MichelCarole Roue-JagotFrancois SellalChristel Thauvin-RobinetCatherine Thomas-AnterionMartine VercellettoNadine GirardEric GuedjMichele PuelIsabelle BerryPierre PayouxElisabeth Auffray-CalvierAmandine PallardyThibaud LebouvierAdeline RollinGregory KuchinskiOlivier MartinaudEmmanuel GerardinPierre VeraAgnes CamuzatMarie ChupinEric BardinetAurelie KasValerie-Causse LemercierMerry MasmanianHerve Oya
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Bordeaux population health Institut du Cerveau = Paris Brain Institute Département Neurologie [CHU Toulouse] Toulouse NeuroImaging Center Institut de Neurosciences des Systèmes CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute
• Publié dans Neurobiology of Disease le 23/10/2020

---

Résumé : GRN mutations are among the main genetic causes of frontotemporal dementia (FTD). Considering the progranulin involvement in lysosomal homeostasis, we aimed to evaluate if plasma lysosphingolipids (lysoSPL) are increased in GRN mutation carriers, and whether they might represent relevant fluid-based biomarkers in GRN-related diseases. We analyzed four lysoSPL levels in plasmas of 131 GRN carriers and 142 non-carriers, including healthy controls and patients with frontotemporal dementias (FTD) carrying a C9orf72 expansion or without any mutation. GRN carriers consisted of 102 heterozygous FTD patients (FTD-GRN), three homozygous patients with neuronal ceroid lipofuscinosis-11 (CLN-11) and 26 presymptomatic carriers (PS-GRN), the latter with longitudinal assessments. Glucosylsphingosin d18:1 (LGL1), lysosphingomyelins d18:1 and isoform 509 (LSM18:1, LSM509) and lysoglobotriaosylceramide (LGB3) were measured by electrospray ionization-tandem mass spectrometry coupled to ultraperformance liquid chromatography. Levels of LGL1, LSM18:1 and LSM509 were increased in GRN carriers compared to non-carriers (p < 0.0001). No lysoSPL increases were detected in FTD patients without GRN mutations. LGL1 and LSM18:1 progressively increased with age at sampling, and LGL1 with disease duration, in FTD-GRN. Among PS-GRN carriers, LSM18:1 and LGL1 significantly increased over 3.4-year follow-up. LGL1 levels were associated with increasing neurofilaments in presymptomatic carriers. This study evidences an age-dependent increase of β-glucocerebrosidase and acid sphingomyelinase substrates in GRN patients, with progressive changes as early as the presymptomatic phase. Among FTD patients, plasma lysoSPL appear to be uniquely elevated in GRN carriers, and thus might serve as suitable non-invasive disease-tracking biomarkers of progression, specific to the pathophysiological process. Finally, this study might add lysoSPL to the portfolio of fluid-based biomarkers, and pave the way to disease-modifying approaches based on lysosomal function rescue in GRN diseases.

---

Fichiers liés : BPH_ND_2023_Khrouf.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2023
• Auteurs : Charlotte BoussardLaure DelageTania GajardoAlexandre KauskotMaxime BatignesNicolas GoudinMarie-Claude StolzenbergCamille BrunaudPatricia PanikulamQuentin RillerMaryse Moya-NilgesJean SolarzChristelle RepérantBéatrice DurelJean-Claude BordetOlivier PelléCorinne LebretonAude MagérusVithura PirabakaranPablo VargasSébastien DupichaudMarie JeanpierreAngélique VinitMohammed ZarhrateCécile MassonNathalie AladjidiPeter D. ArkwrightBrigitte Bader-MeunierSandrine Baron JolyJoy BenadibaElise BernardDominique BerrebiChristine BodemerMartin CastelleFabienne Charbit-HenrionMarwa ChbihiAgathe DebrayPhilippe DrabentSylvie FraitagMiguel HiéJudith Landmann-ParkerLudovic LhermitteDespina MoshousPierre RohrlichFrank RuemmeleAnne Welfringer-MorinMaud TusseauAlexandre BelotNadine Cerf-BensussanMarie RoelensCapucine PicardBénédicte NevenAlain FischerIsabelle CallebautMickaël MénagerFernando E. SepulvedaFrédéric AdamFrédéric Rieux-Laucat
• Organismes : Imagine - Institut des maladies génétiques (IHU) Imagine - Institut des maladies génétiques (IHU) Cytométrie Pitié-Salpêtrière Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé CHU Trousseau [APHP] Centre d'Immunologie et des Maladies Infectieuses CHU Trousseau [APHP] Institut de minéralogie, de physique des matériaux et de cosmochimie Imagine - Institut des maladies génétiques (IHU)
• Publié dans Blood le 28/10/2020

---

Résumé : Dedicator of cytokinesis (DOCK) proteins play a central role in actin cytoskeleton regulation. This is highlighted by the DOCK2 and DOCK8 deficiencies leading to actinopathies and immune deficiencies. DOCK8 and DOCK11 activate CDC42, a RHO-GTPase involved in actin cytoskeleton dynamics, among many cellular functions. The role of DOCK11 in human immune disease has been long suspected but has never been described so far. We studied eight male patients, from seven unrelated families, with hemizygous DOCK11 missense variants leading to reduced DOCK11 expression. The patients were presenting with early-onset autoimmunity, including cytopenia, systemic lupus erythematosus, skin, and digestive manifestations. Patients’ platelets exhibited abnormal ultrastructural morphology and spreading as well as impaired CDC42 activity. In vitro activated T cells and B lymphoblastoid cell lines (B-LCL) of patients exhibited aberrant protrusions and abnormal migration speed in confined channels concomitant with altered actin polymerization during migration. A DOCK11 knock-down recapitulated these abnormal cellular phenotypes in monocytes-derived dendritic cells (MDDC) and primary activated T cells from healthy controls. Lastly, in line with the patients’ autoimmune manifestations, we also observed abnormal regulatory T cells (Tregs) phenotype with profoundly reduced FOXP3 and IKZF2 expression. Moreover, we found a reduced T cell proliferation and an impaired STAT5B phosphorylation upon IL2 stimulation of the patients’ lymphocytes. In conclusion, DOCK11 deficiency is a new X-linked immune-related actinopathy leading to impaired CDC42 activity and STAT5 activation, and associated with abnormal actin cytoskeleton remodeling as well as Tregs phenotype culminating in immune dysregulation and severe early-onset autoimmunity.

---

Fichiers liés : BLD-2022-018486R1_Merged_PDF (1).pdf

---

Source

---

• Type de publi. : Chapître d'ouvrage
• Date de publi. : 01/06/2023
• Auteurs : Philippe ZardJean GoldzinkGérard Gengembre
• Organismes : Littérature et poétique comparées

---

Fichiers liés : postface de Philippe Zard.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 01/06/2023
• Auteurs : Jérôme LuxJean David Lau Hiu HoongPierre-Yves MahieuxPhilippe Turcry
• Organismes : Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 La Rochelle Université
• Publié dans Computers in Industry le 30/10/2020

---

Fichiers liés : S0166361523000398.pdf

---

Source