Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Hiddo HeerspinkJai RadhakrishnanCharles AlpersJonathan BarrattStewart BielerUlysses DivaJula InrigRadko KomersAlex MercerIrene NoronhaMichelle RheaultWilliam RoteBrad RovinHoward TrachtmanHernán TrimarchiMuh Geot WongVlado PerkovicEric AlarmartineJonathan BarrattDong Wan ChaeLucia del VecchioJurgen FloegeShang-Jyh HwangBojan JelakovicBart MaesRobert MaleckiMarius MiglinasFernando Eduardo Barbosa NolascoManual PragaKannaiyan RabindranathMai RosenbergBrad RovinSydney Chi Wai TangVladmir TesarMuh Geot WongBhadran BoseMuralikrishna GangadharanStephen McdonaldChen PehSadia JahanChii YeapPhilip ClaytonGeorgina IrishNikhil ThyagarajanPeter HollettRathika KrishnasamyRobert CarrollShilpanjali JesudasonSusan CrailToby CoatesJane WaughEuan NobleKumaradevan MahadevanVictoria CampbellTania SalehiWai LimNeil BoudvilleAron ChakeraDoris ChanAnoushka KrishnanYusuf EqbalAlastair GilliesEswari VilayurThida Maung Maung MyintNicholas GrayJane WaughEuan NobleMelissa CheethamYusuf EqbalPeter HollettRathika KrishnasamyKumaradevan MahadevanVictoria CampbellCarol PollockBruce CooperAmanda MatherSarah RoxburghYvonne ShenStefanie StangenbergAmanda SiriwardanaEmma O'LoneSusan WanBrendon NeuenJeffrey Tsun Kit HaDana KimLauren HeathArunima JainElaine PhuaYan LiMartin GallagherMeg JardineAngus RitchieMona RazavianCeline FooteRoger WyndhamShaundeep SenZoltan EndreJonathan ErlichMangalee FernandoKenneth YongGrant LuxtonSradha KotwalSimon RogerVidu WijeratneDavid PackhamIan FraserBert VandewieleMargo LauteWim LemahieuSofie JamarSara OmbeletGert MeeusMarc DecupereOlivier SchockaertPeter DoubelLiesbeth ViaeneLuc RadermacherCatherine MassetMartial MoonenEric FirreMartina MilicevicXavier WarlingAn VanackerThomas MalfaitIvan DurlenIvica HorvaticAna SavukLana GellineoSandra KaranovicZivka DikaDjuro PlavljanicIvana MikacicDubravka Trajbar KentricDunja BarisicMarija StankovicKarolina Majstorovic BaracIvan KruljacDrasko PavlovicMartin DrinkovicIngrid PrkacinJerko BarbicZvonimir SitasDunja VujcicIvan RychlikAnna BenesovaKlara DrinovskaKarolina KratkaDita MaixnerovaMadis IlmojaKristin UntKadri LilienthalAsta AuerbachLiisi LeisJulia PielAnnika AdobergKulli KolvaldKristi VeermaeKadri TellingElviira SeppetJana UhlinovaPhilippe ZaouiPierre-Louis CarronIngrid MassonMiriana DinicDamien ThibaudinChristian BroyetNicolas MaillardHesham MoheyChristophe MariatGuillaume ClaisseEric AlamartineBertrand DussolStephane BurteyNoemie Chiche-JourdeJean-Emmanuel SerreGuillaume JeantetLeila ChenineAnne BlanchardStephane RoueffÉric ThervetDavid FouassierAlexandre BuffetMarine LivrozetRoxane GaissetAlexandre KarrasAnne-Elisabeth HengCyril GarrousteCarole PhilipponnetClementine NicoloAlba AtenzaCamille LanaretClarisse GrezeValentin MayetClement DumondYahsou DelmasChristian CombeClaire RigothierLaure BurguetAurore LabatSimon MuchaValérie de PrécigoutThomas WeinreichHelmut ReichelDiliana DraganovaLothar WolfBernd HohensteinSven HeinrichsSimone KulkaSebahat SatLea WeilandThilo KruegerGunter WolfChristiane KettnerMandy SchlosserJohann Konstantin HerfurthAnnegret KochMartin BuschStephan Christian WerthMartin NitschkeFigen CakirogluFranziska SarnowLisa SchulzStefan WeinerNikolaus WirtzEric KoesterMarcus MoellerEleni StamellouSilja SandenHans Schmidt-GuertlerWanja BernhardtMargret PateckiGeorg SchlieperKevin SchulteAnnette GirardetUlrich KunzendorfLorraine Pui Yuen KwanMaggie Ming Yee MokGary Chi Wang ChanMingyao MaDavina Ngoi Wah LieAnthony Ting Pong ChanCheuk Chun SzetoKit Chung Jack NgSiu Fai CheungTak Tai Andrew YueKa Shun Samuel FungHon TangKa Fai YimWai Ping LawYick Hei WongChi Kwan Darwin LamSze Ho Sunny WongCarmelita MarcantoniRoberta AliottaFrancesca DeodatoGemma PatellaNicolino ComiCaterina VitaNazareno CarulloDavide BolignanoMichela MusolinoMatias TrilliniNorberto PericoGiuseppe RemuzziErica DainaLuigi BianconeLoredana CollaManuel BurdeseChiara CognoElena BoaglioIsabella AbbascianoCarlotta Federica ZizziPaolo RandonePietro NapodanoAnna RicchiutoMatthias CassiaSimone AccarinoMario CozzolinoRocco BaccaroStefano CostanziFederica Di MaioMaria ArenaFederica UrciuoloSara ViganoAndrea CavalliMonica LimardoMonica BordoliSerena PontiSelena LonghiAndrea SolazzoFrancesco GiaroniGabriele DonatiMassimo TorreggianiDavide CatucciMarco ColucciVittoria EspositoCiro EspositoLoreto GesualdoFlavia CapaccioEmma Diletta SteaCarmen SivoFrancesca AnneseFederica PapadiaPiergiorgio MessaMirco BelingheriPatrizia PasseriniSilvia MalvicaAlvita VickieneUrte ZakauskieneEgle AsakieneInga Arune BumblyteAsta StankuvieneLina SantockieneAshik HayatAllister WilliamsPeter SizelandEddie TanGerald WatersLai Wan ChanAndrew HendersonAngus TurnbullAndrew McnallyAnnie ReynoldsHelen PilmoreIan DittmerPaul ManleyElizabeth StallworthyTze GohDavid SempleMichael CollinsElizabeth CurryJafar AhmedThu NguyenAgata WiniarskaJustyna ZbrzezniakTomasz StomporMagdalena KrajewskaHanna Augustyniak-BartosikDorota ZielinskaAnna JanderMalgorzata StanczykMarcin TkaczykPrzemyslaw MiarkaDariusz AksamitPiotr JaskowskiWladyslaw SulowiczDominik CieniawskiJulita Gontarek-KacprzakElzbieta FelicjanczukNorbert KwellaBogna KwellaEwa SatoraJoão Carlos FernandesAna Marta GomesMarina ReisDaniela LopesCatarina AlmeidaHelena SáAna Carolina FigueiredoClara PardinhasEdgar AlmeidaMario RaimundoAna Cortesão CostaLuis Pedro Falcao GoncalvesSara FernandesSónia SilvaCatarina TeixeiraAdriana FernandesFernando NolascoPatricia AlvesMario GoisNuno FonsecaAna MessiasMaria MenezesFilipa CardosoHelena SousaJoana MarquesRui BarataJose Antonio LopesSofia JorgeJoana GameiroJose Nuno de Almeida Agapito FonsecaSara GoncalvesAna FarinhaPatricia Valerio SantosAna NatarioJose Carlos de Jesus BarretoCatarina AbrantesElsa Sofia Quadrado SoaresJoana de Sousa Soares FelgueirasLiliana CunhaLucia ParreiraTeresa FurtadoAlvaro VazKook-Hwan OhHajeong LeeSe Joong KimJong Cheol JeongYeong Hoon KimYunmi KimHyeong Cheon ParkHoon Young ChoiHyung Wook KimMoon Hyoung LeeSonguk YoonKyu-Beck LeeYoungyoul HyunTae-Hyun YooSeung Hyeok HanJung Tak ParkSunggyun KimYoung Rim SongJwa-Kyung KimHyung-Seok LeeNarae JooJungeun LeeHye Ryoun JangJunseok JeonWookyung ChungHyunhee LeeJae Hyun ChangKa Yeong ChunJi Yong JungHan RoAejin KimSang-Kyung JoJihyun YangMyung-Gyu KimSewon OhCaridad Martinez VillanuevaAna Vilar GimenoGustavo Andres Useche BonillaEsther TamaritAntonio Galan SerranoEduardo Verde MorenoJose Luño FernandezMaria Angeles Goicoechea DiezhandinoUrsula Verdalles GuzmanAna Perez de JoseAlberto Ortiz ArduanMaría Vanessa Pérez GómezCatalina Martín ClearyRaul Fernandez PradoElena GomaJose BallarinMontserrat Diaz EncarnacionIara da Silva SantosHelena Marco RusinolMonica FurlanoCarlos AriasClara BarriosEva Rodriguez GarciaAdriana Sierra OchoaBelen Vizcaino CastilloJonay Pantoja PerezMercedes Gonzalez MoyaMari SargsyanEmma Calatayud AristoyAna Avila BernabeuLeticia Perez LlunaTamara Malek MarinMaria Antonia Munar VilaIvon Maritza Bobadilla RicoNatalia Allende BurgosEduardo Gutierrez MartinezElena Gutierrez SolisAngel SevillanoEvangelina Merida HerreroJosep Miquel Blasco PelicanoLida Maria Rodas MarinLuis QuintanaMaria Antonieta Azancot RiveroNatalia Ramos TerradesClara Garcia CarroIrene Agraz PamplonaMercedes Salgueira LazoFrancisco de la Prada AlvarezFabiola Alonso GarciaWenceslao Adrian Aguilera MoralesSalia Virxinia Pol HeresAngel ForcenEduardo Parra MoncasiCristina Medrano VillarroyaAlejandro Soria VillenOlga Gracia GarciaMercedes Velo PlazaMaria Dolores Sánchez de la NietaMarta Calvo ArevaloAntolina MorenoSecundino Cigarran GuldrisManuel Pereira de VicenteMaria Antonia Munar VilaIvon Maritza Bobadilla RicoNatalia Allende BurgosBang-Gee HsuChih-Hsien WangCheng-Hsu ChenTung-Min YuMing-Ju WuShang-Feng TsaiChia-Tien HsuHsien-Fu ChiuKang-Ju ChouHua-Chang FangPo-Tsang LeeHsin-Yu ChenChien-Liang ChenChien-Wei HuangShih-Hsiang OuTzung-Yo HoChih-Yang HsuMing-Shan ChangYen-Ling ChiuYu-Sen PengKai-Hsiang ShuSzu-Yu PanShih-Ping HsuJu-Yeh YangMei-Fen PaiPo-Yu TsengHon-Yen WuWan-Chuan TsaiKuei-Ting TungHung-Yuan ChenHung-Chun ChenMei-Chuan KuoDaw-Yang HwangYi-Wen ChiuChi-Chih HungHung-Tien KuoJer-Chia TsaiKieran MccaffertySuzanne ForbesIndranil DasguptaMark ThomasAmar MahdiBamidele AjayiParamit ChowdhuryTheodoros KasimatisDimitrios MoutzourisCaroline DudreuilhRishi PruthiNick MansfieldGabriel DoctorSapna ShahSui KonPriscilla SmithPatrick HamiltonDurga KanigicherlaOmar Sherin Ibrahim RagyBassam AlchiOliver FlossmannFarid GhalliSarah LawmanSmeeta SinhaConstantina ChrysochouChukwuma ChukwuAine Maire de BhailisSaif Al ChalabiAmy HudsonArun GopuOlivia WickensJoshua StorrarMona WahbaNathan LordeMohammad RonySian GriffinFarah LatifMohammad AliLouise DasilvaJonathan Ayling-SmithEamon MahdiLisa WillcocksRachel JonesChee Kay CheungHaresh SelvaskandanDan PughMatthew SayerNeeraj DhaunFiona ChapmanPatrick MarkColin GeddesEmily McquarrieRajan PatelLaurence SolomonArvind PonnusamyAdam MorrisPedro OkohLauren FloydAjay DhaygudeJanson LeungChristopher GoldsmithBhavna PandyaDidem TezAshraf MikhailKaren BrownThomas BucknallMark LambieRoderick ComunaleDonald BrandonStacy MartinezAmanda HallAmy HendersonAaron FeardayNicole DouthitBrian SnowArnold SilvaCathylee SlyChristopher KellerRobert DavidsonJerry MengRobert HawsSiddhartha KattamanchiJavad MojarrabUnnikrishnan PillaiRichard LafayetteMichelle O'ShaughnessyFahameedah KamalKshama MehtaBruce BakerMario RuizPraveena JyothinagaramUsha PeriWilliam PaxtonJames TumlinKerri McgrealEllen MccarthyCassandra KimberArchana GautamKassem KhalilViet NguyenViet NguyenRaffi MinasianDariush ArfaaniaSam DaneshvariMichel ZakariArtashes PatrikyanRouzbeh AfsariChristine AyvazyanFaisal FakihMark LagattaFaisal FakihAlfred RodriguezJorge Enrique Monroy AvellaRamachandra PatakJigar KadakiaJai RadhakrishnanGerald AppelWooin AhnBradley NelsonAllyson MedinaSyeda AhmadYonatan PelegNisha ClementIan ChiuElizabeth HendrenAndrew BombackPietro CanettaBruce SpinowitzChaim CharytanNishita ParikhSheng KuoRitesh RaichoudhuryMirela DobreLavinia NegreaAparna PadiyarArksarapuk JittiratNishigandha PradhanRanjit DhelariaSaravanan BalamuthusamyMachaiah MadhriraThomas PowellHoward LiflandAsha BaileySarah Ashley Ford SightlerMeera Patel SutharHeather GreenSamir ParikhIsabelle AyoubSalem AlmaaniGabriel ContrerasAlessia FornoniYelena DrexlerAbdallah GearaBrittany SheridanGaia CoppockJonathan HoganCarlos GonzalezShamik BhadraPradip ChowdhuryKay KyawMay TanLathika RaakeshElder MendozaVeronica ViramontesAsghar ChaudhryJuan CarbonellRajdeep GadhVictor FernandezMohamad KassemRadu JacobKaren WilderBritt NewsomeKathryn KlammIrina SuyumovaLaura Ann KooiengaCatherine JankoDana RizkBruce JulianDawn CasterErika PerezGunjan GargNayan GowdaSuneel UdaniSreedhar MandayamBiruh WorkenehRoderick ComunaleDonald BrandonUnnikrishnan PillaiAli AssefiBarbara GrecoMichael GermainJusmin PatelSarah QuinnJames SullivanJeffrey GlazePhillip MadoniaKellyn McmahonHarold GilesSharon AdlerTiane Dai
• Organismes : University of Groningen [Groningen] University of New South Wales [Sydney] KI Editorial Board Columbia University Medical Center University of Leicester University of Minnesota Medical School The Ohio State University [Columbus] New York University Langone Medical Center University of New South Wales [Sydney] University of Leicester Role of intra-Clonal Heterogeneity and Leukemic environment in ThErapy Resistance of chronic leukemias Service Néphrologie, Hémodialyses [CHU Clermont-Ferrand]
• Publié dans The Lancet le 02/11/2020

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Résumé : Background: Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety. Methods: PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 years) with biopsy-proven IgA nephropathy and proteinuria of 1·0 g/day or higher despite maximised renin-angiotensin system inhibitor treatment for at least 12 weeks. Participants were randomly assigned in a 1:1 ratio to receive sparsentan 400 mg once daily or irbesartan 300 mg once daily, stratified by estimated glomerular filtration rate at screening (30 to <60 mL/min per 1·73 m2 and ≥60 mL/min per 1·73 m2) and urine protein excretion at screening (≤1·75 g/day and >1·75 g/day). The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. All endpoints were examined in all participants who received at least one dose of randomised treatment. The study is ongoing and is registered with ClinicalTrials.gov, NCT03762850. Findings: Between Dec 20, 2018, and May 26, 2021, 404 participants were randomly assigned to sparsentan (n=202) or irbesartan (n=202) and received treatment. At week 36, the geometric least squares mean percent change from baseline in urine protein-creatinine ratio was statistically significantly greater in the sparsentan group (-49·8%) than the irbesartan group (-15·1%), resulting in a between-group relative reduction of 41% (least squares mean ratio=0·59; 95% CI 0·51-0·69; p<0·0001). TEAEs with sparsentan were similar to irbesartan. There were no cases of severe oedema, heart failure, hepatotoxicity, or oedema-related discontinuations. Bodyweight changes from baseline were not different between the sparsentan and irbesartan groups. Interpretation: Once-daily treatment with sparsentan produced meaningful reduction in proteinuria compared with irbesartan in adults with IgA nephropathy. Safety of sparsentan was similar to irbesartan. Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Alexandra BaekelandtVandasue L R SaltenisPhilippe NacryAleksandra MalyskaMarc CornelissenAmrit Kaur NandaAbhishek NairPeter RogowskyLaurens PauwelsBertrand MullerJonas CollénJonas BlommeMathias PribilLars B ScharffJessica DaviesRalf WilhelmNorbert RollandJeremy HarbinsonWout BoerjanErik H MurchieAlexandra J BurgessJean‐pierre CohanPhilippe DebaekeSebastien ThomineDirk InzéRené Klein LankhorstMartin a J Parry
• Organismes : Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics Universiteit Gent = Ghent University = Université de Gand Københavns Universitet = University of Copenhagen = Université de Copenhague Institut des Sciences des Plantes de Montpellier European Commission - DG Research and Innovation BASF Agricultural Solutions Belgium NV Plants for the Future European Technology Platform Wageningen University and Research [Wageningen] Reproduction et développement des plantes Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics Écophysiologie des Plantes sous Stress environnementaux Laboratoire de Biologie Intégrative des Modèles Marins Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics Department of Plant and Environmental Sciences [Copenhagen] Department of Plant and Environmental Sciences [Copenhagen] Department of Plant and Environmental Sciences [Copenhagen] Julius Kühn-Institut - Federal Research Centre for Cultivated Plants Dynamique du protéome et biogenèse du chloroplaste Wageningen University and Research [Wageningen] Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics University of Nottingham, UK University of Nottingham, UK ARVALIS - Institut du Végétal [Ouzouer le Marché] AGroécologie, Innovations, teRritoires Institut de Biologie Intégrative de la Cellule Department of Plant Systems Biology, VIB, and Department of Plant Biotechnology and Bioinformatics Wageningen University and Research [Wageningen] Lancaster Environment Centre
• Publié dans Food and Energy Security le 29/10/2020

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Résumé : To meet the increasing global demand for food, feed, fibre and other plant- derived products, a steep increase in crop productivity is a scientifically and technically challenging imperative. The CropBooster- P project, a response to the H2020 call ‘Future proofing our plants’, is developing a roadmap for plant research to improve crops critical for the future of European agriculture by increasing crop yield, nutritional quality, value for non- food applications and sustainability. However, if we want to efficiently improve crop production in Europe and pri- oritize methods for crop trait improvement in the coming years, we need to take into account future socio- economic, technological and global developments, in- cluding numerous policy and socio- economic challenges and constraints. Based on a wide range of possible global trends and key uncertainties, we developed four extreme future learning scenarios that depict complementary future devel- opments. Here, we elaborate on how the scenarios could inform and direct fu- ture plant research, and we aim to highlight the crop improvement approaches that could be the most promising or appropriate within each of these four future world scenarios. Moreover, we discuss some key plant technology options that would need to be developed further to meet the needs of multiple future learning scenarios, such as improving methods for breeding and genetic engineering. In addition, other diverse platforms of food production may offer unrealized poten- tial, such as underutilized terrestrial and aquatic species as alternative sources of nutrition and biomass production. We demonstrate that although several meth- ods or traits could facilitate a more efficient crop production system in some of the scenarios, others may offer great potential in all four of the future learning scenarios. Altogether, this indicates that depending on which future we are head- ing toward, distinct plant research fields should be given priority if we are to meet our food, feed and non- food biomass production needs in the coming decades.

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Fichiers liés : Food and Energy Security - 2023 - Baekelandt -.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Kyoka KuroiwaBenoit DaniloLaura PerrotChristina ThenaultFlorian VeilletFabien DelacotePhilippe DuchateauFabien NoguéMarianne MazierJean-Luc Gallois
• Organismes : Génétique et Amélioration des Fruits et Légumes Génétique et Amélioration des Fruits et Légumes Toulouse Biotechnology Institute Génétique et Amélioration des Fruits et Légumes Institut de Génétique, Environnement et Protection des Plantes Institut Jean-Pierre Bourgin - Sciences du végétal Génétique et Amélioration des Fruits et Légumes Génétique et Amélioration des Fruits et Légumes
• Publié dans Plant Biotechnology Journal le 02/11/2020

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Résumé : Resistance to potyviruses in plants has been largely provided by the selection of natural variant alleles of eukaryotic translation initiation factors (eIF) 4E in many crops. However, the sources of such variability for breeding can be limited for certain crop species, while new virus isolates continue to emerge. Different methods of mutagenesis have been applied to inactivate the eIF4E genes to generate virus resistance, but with limited success due to the physiological importance of translation factors and their redundancy. Here, we employed genome editing approaches at the base level to induce non-synonymous mutations in the eIF4E1 gene and create genetic diversity in cherry tomato (Solanum lycopersicum var. cerasiforme). We sequentially edited the genomic sequences coding for two regions of eIF4E1 protein, located around the cap-binding pocket and known to be important for susceptibility to potyviruses. We show that the editing of only one of the two regions, by gene knock-in and base editing, respectively, is not sufficient to provide resistance. However, combining amino acid mutations in both regions resulted in resistance to multiple potyviruses without affecting the functionality in translation initiation. Meanwhile, we report that extensive base editing in exonic region can alter RNA splicing pattern, resulting in gene knockout. Altogether our work demonstrates that precision editing allows to design plant factors based on the knowledge on evolutionarily selected alleles and enlarge the gene pool to potentially provide advantageous phenotypes such as pathogen resistance.

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Fichiers liés : Plant Biotechnology Journal - 2023 - Kuroiwa - An iterative gene‐editing strategy broadens eIF4E1 genetic diversity in.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Étienne CrickxMikael EbboEtienne RivièreOdile Souchaud-DebouverieLouis TerriouSylvain AudiaMarc RuivardBouchra AsliJean-Pierre MarolleauNadine Méaux-RuaultMathieu Gerfaud-ValentinPhilippe AudeguyMohamed HamidouSelim CormXavier DelbrelJean FontanDelphine LebonChristelle MausserveyGuillaume MoulisNicolas LimalMarc MichelBertrand GodeauMatthieu Mahévas
• Organismes : Institut Necker Enfants-Malades Institut Mondor de Recherche Biomédicale Centre d'Immunologie de Marseille - Luminy Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases Institute for Translational Research in Inflammation - U 1286 Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand CHU Estaing [Clermont-Ferrand] Centre Hospitalier Edouard Herriot-Lyon CHU Amiens-Picardie HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Service de médecine interne Hospices Civils de Lyon Hôpital de la Croix-Rousse [CHU - HCL] Université Claude Bernard Lyon 1 Médipôle De Savoie Service de Médecine Interne [Pau] Service d'hématologie CHU Amiens-Picardie HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666 Centre Hospitalier Universitaire de Toulouse
• Publié dans British Journal of Haematology le 29/10/2020

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Résumé : Combining drugs could be an effective option for treating multirefractory ITP, that is, patients not responding to rituximab, thrombopoietin receptor agonists (TPO-RA) and splenectomy. We conducted a retrospective, multicenter, observational study including multirefractory ITP patients who received a combination of a TPO-RA and an immunosuppressive drug. We included 39 patients (67% women, median age 59 years [range 21-96]), with a median ITP duration of 57 months [3-393] and a median platelet count at initiation of 10 × 109 /L [1-35]. The combination regimen was given for a median duration of 12 months [1-103] and included eltrombopag (51%) or romiplostim (49%), associated with mycophenolate mofetil (54%), azathioprine (36%), cyclophosphamide (5%), cyclosporin (3%) or everolimus (3%). Overall, 30 patients (77%) achieved at least a response (platelet count ≥30 × 109 /L and at least doubling baseline during at least 3 months), including 24 complete responses (platelet count >100 × 109 /L during at least 3 months) with a median time to response of 30 days [7-270] and a median duration of response of 15 months [4-63]. Severe adverse event related to ITP treatment was observed in 31%. In conclusion, this study confirms that some patients with multirefractory ITP can achieve long lasting response with this combination.

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• Type de publi. : Rapport
• Date de publi. : 01/05/2023
• Auteurs : Rodolphe LeméeJean-François HumbertÉric AbadieZouher AmzilElisa BerdaletRonel BiréMarie-Yasmine Dechraoui BotteinLuc de HaroNicolas DelcourtValérie FessardJean-Philippe JaegCésar MatteiAnne OppligerAnne-Sophie PavauxEva TernonGilles BornertJean-François HumbertAnne TogolaJean BaronJean-Luc BoudenneNicolas CimetiereBruno CoulombChristophe DagotSabine DenoozIsabelle DublineauFrédéric FederMatthieu FournierStéphane Garnaud-CorbelNathalie GarrecJohnny GasperiJulio GonçalvèsJean-Louis GonzalezOlivier HornerMichel JoyeuxJérôme LabanowskiSophie Lardy-FontanFrançoise LucasChristophe MechoukLaurent MoulinDamien MoulyFabienne PetitCatherine QuiblierPauline Rousseau-GueutinMarie-Pierre Sauvant-RochatMichèle TremblayBruno Le BizecMarie-Louise ScippoClaude AtgiePierre-Marie BadotMarie-Yasmine BotteinRachida ChekriChristine DemeilliersNicolas DelcourtVirginie DesvignesErwan EngelGautier EppeAnne-Sophie FicheuxEric HoudeauEmilie LanceOlivier LaprevoteMichel LaurentieLudovic Le HegaratJean-Charles LeblancNicolas LoiseauDavid MakowskiFrancesca ManciniEric MarchioniJean-Francois MasfaraudMathilde MunierIsabelle OswaldAnne PlatelYann SivryPaule VasseurCarole CatastiniNathalie ArnichEstelle Checlair-WesterbergEleonore Ney
• Organismes : Sorbonne Université Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Institut Français de Recherche pour l'Exploitation de la Mer Institut Français de Recherche pour l'Exploitation de la Mer Institut national des sciences et techniques de la mer Laboratoire de sécurité des aliments de Maisons-Alfort Université Côte d'Azur Centre antipoison et de toxicovigilance (Marseille) Centre Régional de PharmacoVigilance [CHU Toulouse] Laboratoire de Fougères - ANSES École nationale vétérinaire de Toulouse Université d'Angers Centre universitaire de médecine générale et santé publique CentraleSupélec Laboratoire d'océanographie de Villefranche Service de Santé des Armées Institut d'écologie et des sciences de l'environnement de Paris Bureau de Recherches Géologiques et Minières Eau de Paris Laboratoire Chimie de l'environnement Institut des Sciences Chimiques de Rennes Laboratoire Chimie de l'environnement Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Société wallonne des eaux Unité d'expertise des sites et des déchets radioactifs Recyclage et risque Département Performances des systèmes de production et de transformation tropicaux Morphodynamique Continentale et Côtière Office français de la biodiversité Centre Scientifique et Technique du Bâtiment Eau et Environnement Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement Laboratoire Environnement Ressources Provence Azur Corse Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] Laboratoire d'hydrologie de Nancy Laboratoire Eau Environnement et Systèmes Urbains Eau de Paris Direction santé environnement travail - Santé Publique France Morphodynamique Continentale et Côtière Molécules de Communication et Adaptation des Micro-organismes École des Hautes Études en Santé Publique Département des sciences en santé environnementale Université de Rennes Université Clermont Auvergne Laboratoire Chrono-environnement (UMR 6249) Environnement et Prévention en Santé des Populations Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Direction de l'Evaluation des Risques Direction de l'Evaluation des Risques Direction de l'Evaluation des Risques Direction de l'Evaluation des Risques

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Résumé : Au cours des dernières décennies, plusieurs espèces de dinoflagellés du genre Ostreopsis ont été identifiées dans les eaux marines de pays européens tels que l’Albanie, la Croatie, Chypre, l'Espagne, la France, la Grèce, l'Italie, Monaco et le Portugal. Ces microalgues peuvent causer des intoxications humaines lorsque les cellules ou les toxines qu’elles produisent sont présentes dans l’eau de mer, les aérosols ou dans certains produits de la mer. La voie principale d’exposition de l’Homme est l’inhalation d’aérosols sans que l’on sache actuellement si les agents à l’origine des intoxications sont les cellules d’Ostreopsis, les débris cellulaires, des toxines connues produites par Ostreopsis ou d’autres composés non encore identifiés. D’autres voies d’exposition (contact cutané, contact oculaire, ingestion d’eau ou de produits de la mer contaminés) sont possibles. Les intoxications se manifestent par divers signes et symptômes (survenant moins de 48h après l’exposition) : - neurosensoriels et neurologiques : paresthésies (sensation de fourmillements), dysesthésies (sensation de brûlure) et céphalées ; - respiratoires, de la sphère ORL et stomatologiques : dysgueusie à type de goût métallique, rhinorrhée, toux, gêne respiratoire ; - cutanés évoquant de l’urticaire ; - cardiaques : tachycardie, poussée hypertensive ; - digestifs : nausées, vomissements, diarrhée ; - systémiques : fièvre ; - locomoteurs : myalgies et arthralgies (douleurs musculaires et articulaires). Elles surviennent lors de diverses situations : - travail ou activités récréatives dans la mer (baigneurs, maîtres-nageurs, pêcheurs professionnels, surfeurs, etc.) ; - travail ou activités récréatives sur ou à proximité de la plage (estivants, secouristes, agents en charge du nettoyage des plages, restaurateurs, etc.) ; - séjour ou résidence à proximité immédiate du bord de mer ; - consommation de produits de la mer contaminés. En France, la présence d’Ostreopsis est identifiée de façon récurrente sur les côtes méditerranéennes depuis une quinzaine d’années alors qu’elle est beaucoup plus récente sur les côtes basques française et espagnole. Deux espèces ont été identifiées sur la côte basque : O. cf. siamensis et O. cf. ovata. Si la première, O. cf. siamensis, est observée sur cette côte depuis 2018, la seconde, O. cf. ovata, a été observée dans cette partie du golfe de Gascogne pour la première fois en 2021. Le bilan épidémiologique montre que près de 900 personnes ont développé des signes et des symptômes associés aux proliférations d’Ostreopsis sur la côte basque française depuis 2020. Ce bilan montre par ailleurs qu’il n’existe pas de différence clinique avec les effets observés lors des épisodes de prolifération d’Ostreopsis cf. ovata du pourtour méditerranéen. [Saisines liées n°2007-SA-0227 et 2007-SA-0303]

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• Type de publi. :
• Date de publi. : 01/05/2023
• Auteurs : Olivier Las VergnasPhilippe Carré
• Organismes : CREF: Équipe Apprenance et Formation des Adultes Trigone-CIREL Centre Interuniversitaire de Recherche en Education de Lille - ULR 4354 CREF: Équipe Apprenance et Formation des Adultes
• Publié dans Savoirs : Revue internationale de recherches en éducation et formation des adultes le 24/10/2020

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Résumé : Voici déjà 20 ans que Savoirs a vu le jour à l’initiative de l’équipe de formation des adultes de l’université Paris Nanterre animée par Jacky Beillerot, premier directeur de la publication qui malheureusement nous a quittés brusquement l’année suivante, dès le 3e numéro de la revue. Depuis 2003, ces vingt années ont donné lieu à la publication de 60 numéros, au rythme régulier de trois par année ; la plupart sont thématiques et centrés sur leur Note de synthèse faisant le point sur les recherches produites en France et à l’international autour d’une question marquant l’éducation ou la formation des adultes. Les autres sont, plus classiquement, dénommés Varia. [...] Quant à ce présent numéro 61-62 de la toute jeune vie adulte de notre revue, il est consacré dans ce qui suit à la formation des adultes comme champ de recherche caractéristique des vingt années écoulées. Il est organisé autour d’un dossier de 9 articles construits à partir d’une enquête bibliométrique du contenu des 119 articles de recherche publiés dans la revue entre 2003 et 2022. Cette enquête est présentée et commentée sur le double plan de ses résultats et de sa méthodologie par deux contributions des coordinateurs du numéro. Le dossier central est ensuite constitué de sept articles, correspondant chacun à l’une des « familles » de recherche identifiées par l’analyse lexicométrique initiale. Leurs contenus sont présentés dans l’introduction générale du dossier qui suit cet Éditorial. Ces sept articles sont suivis par deux derniers apports ; le premier s’essaie à une mise en ordre des articles de recherche publiés depuis vingt ans, en partant d’un double point de vue : d’une part celui des échelles d’observation utilisées, d’autre part celui des niveaux d’analyse retenus par leur auteur. Le second clôt le numéro par un bilan accompagné de prospective concernant les pratiques et recherches en éducation des adultes au Québec durant la période 2000-2020. Le lecteur trouvera opportunément dans cet article final des pistes pour aborder la distinction à faire entre éducation et formation des adultes, cette dernière étant ici entrevue comme un sous-ensemble de la première. Jean-Pierre Boutinet

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• Type de publi. : Article dans une revue
• Date de publi. : 01/05/2023
• Auteurs : Thierry BoulainMai-Anh NayPierre-François DequinJean-Baptiste LascarrouPhilippe VignonToufik KamelGrégoire MullerStephan EhrmannOlivier BaudinSylvie CalvatChristophe CraccoArnault DesachyCharles LafonEmmanuelle BoitrouArnaud FollinHervé MentecOlivier PajotGaëtan PlantefèveMarina ThirionRémi BruyèreJean-Pierre QuenotKonstantinos BachoumasMaud FiancetteJean Claude LacheradeChristine LebertLaurent Martin-LefèvreJean ReignierIsabelle VinatierAihem YehiaEmmanuelle BegotRemy BellierMarc ClavelBruno FrançoisAntoine GalyNicolas PichonPatrick BardouFrédéric BellecMichel BonnivardAnne MarcoJérôme RoustanSylvie VimeuxAnne BretagnolArmelle MathonnetNicolas BercaultToufik KamelGrégoire MullerFrançois RéminiacIsabelle RungeMarie SkarzynskiDelphine ChatellierRémi CoudroyJean-Pierre FratVéronique GoudetRené RobertAnne VeinsteinVlad BotocStéphanie ChevalierFrançois ColletJean-Paul GouelloJulie BadinAntoine GuillonAnnick LegrasElodie MasseretEmmanuelle MercierPatrice Talec
• Organismes : Centre Hospitalier Régional d'Orléans Centre Hospitalier Régional d'Orléans Centre d’Investigation Clinique [CHRU Tours] Centre d’Etude des Pathologies Respiratoires [Tours] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Hôtel-Dieu [CHU Nantes] Service de Réanimation Polyvalente [CHU Limoges] Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques Centre Hospitalier Régional d'Orléans Centre Hospitalier Régional d'Orléans Centre d’Etude des Pathologies Respiratoires [Tours] Centre d’Investigation Clinique [CHRU Tours]
• Publié dans Australian Critical Care le 02/11/2020

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Résumé : PurposeThe purpose of this study was to assess the predictive performance of pulse oximetry (SpO2) to rule out hypoxaemia and hyperoxia in critically ill patients.MethodsSpO2, arterial oxygenation (SaO2), and arterial partial pressure of oxygen (PaO2) were prospectively and simultaneously measured every 6 h during the first 24 h of intensive care unit admission in a multicentre cohort of critically ill patients suffering acute circulatory failure. Likelihood ratios associated with different cutoff values of SpO2 to rule out hypoxaemia (SaO2 < 90% or PaO2 < 60 mmHg) or hyperoxia (SaO2 > 95% or PaO2 > 100 mmHg) and post-test probabilities were calculated. Mean bias between SpO2 and SaO2 and agreement interval were calculated. Area under the receiver operating characteristics associated with SpO2 to predict different threshold values of SaO2 and PaO2 were calculated.ResultsFive hundred seventy-one patients (mean [standard deviation] Simplified Acute Physiology Score II: 58.7 [20.1]; mechanically ventilated 75.6%) with 2643 available SaO2 and PaO2 samples and corresponding 2643 SpO2 values were analysed. Mean bias between SpO2 and SaO2 was 1.1%, and its agreement interval ranged from −8.2 to +11.1%. SpO2 cutoff values of 88%, 90%, and 92% left the possibility that 8%–13% of patients had hypoxaemia. SpO2 < 95% left the possibility that 31% of patients had hyperoxia. All calculated areas under the receiver operating characteristics showed a lower limit of their 95% confidence interval below 0.85ConclusionIn this cohort of patients with circulatory failure, SpO2 had poor discriminative ability to rule out hypoxaemia and hyperoxia. Overconfidence upon SpO2 monitoring may be dangerous.

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Fichiers liés : S103673142200042X.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 28/04/2023
• Auteurs : Jildaz CaroffLaurent AubertCécile Lavenu-BombledSamy FigueiredoKamelia HabchiJonathan CorteseFrançois EugèneJulien OgnardFlorence TahonGéraud ForestierHeloise IferganFrançois ZhuJean-François HakAnthony ReyreMorgane LaubacherAbdoulaye TraoreJean Philippe DesillesImad DerrazRicardo MorenoMarc BintnerGuillaume CharbonnierAnthony Le BrasLouis VeunacFlorent GarielHocine RedjemJacques SedatGuillaume TessierVictor DumasMaxime GaubertiCyril ChivotArturo ConsoliNicolas BricoutTitien TuilierAlexis GuedonRaoul PopPierre ThouantGuillaume BellangerRiccardo ZannoniSebastien SoizeJohann Sebastian RichterOlivier HeckCristian MihaleaJulien BurelJean-Baptiste GirotEimad ShotarSebastian GazzolaGrégoire BoulouisBasile Kerleroux
• Organismes : Service de Neuroradiologie [CHU de Bicêtre] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] AP-HP. Université Paris Saclay Hémostase, Inflammation, Thrombose Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Service de Neuroradiologie [CHU de Bicêtre] Laboratoire Traitement du Signal et de l'Image Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Laboratoire de Traitement de l'Information Medicale Centre Hospitalier Régional Universitaire de Brest CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Service de Neurologie [CHU Limoges] Service de neuroradiologie [CHRU Tours] Université de Lorraine Département de Neuroradiologie [CHRU Montpellier] Laboratoire d'Imagerie Interventionnelle Expérimentale Centre Européen de Recherche en Imagerie médicale Département de Radiologie [Hôpital de la Timone - APHM] Hospices Civils de Lyon Service de Neurologie [Hôpitaux Civils de Colmar] Fondation Ophtalmologique Adolphe de Rotschild Université Paris Cité Laboratoire de Recherche Vasculaire Translationnelle Département de Neuroradiologie [CHRU Montpellier] Service Neurologie [CHU Clermont-Ferrand] Centre Hospitalier Universitaire de La Réunion
• Publié dans Journal of Neurointerventional Surgery le 26/10/2020

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Résumé : Background Neurointerventionists lack guidelines for the use of antithrombotic therapies in their clinical practice; consequently, there is likely to be significant heterogeneity in antithrombotic use between centers. Through a nationwide survey, we aimed to obtain an exhaustive cross-sectional overview of antithrombotic use in neurointerventional procedures in France. Methods In April 2021, French neurointerventional surgery centers were invited to participate in a nationwide 51-question survey disseminated through an active trainee-led research collaborative network (the JENI-RC). Results All 40 centers answered the survey. Fifty-one percent of centers reported using ticagrelor and 43% used clopidogrel as premedication before intracranial stenting. For flow diversion treatment, dual antiplatelet therapy was maintained for 3 or 6 months in 39% and 53% of centers, respectively, and aspirin was prescribed for 12 months or more than 12 months in 63% and 26% of centers, respectively. For unruptured aneurysms, the most common heparin bolus dose was 50 IU/kg (59%), and only 35% of centers monitored heparin activity for dose adjustment. Tirofiban was used in 64% of centers to treat thromboembolic complications. Fifteen percent of these comprehensive stroke centers reported using tenecteplase to treat acute ischemic strokes. Cangrelor appeared as an emergent drug in specific indications. Conclusion This nationwide survey highlights the important heterogeneity in clinical practices across centers. There is a pressing need for trials and guidelines to further evaluate and harmonize antithrombotic regimens in the neurointerventional field.

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• Type de publi. : Article dans une revue
• Date de publi. : 27/04/2023
• Auteurs : M. KhamaysaM. LefortM. Pélégrini-IssacA. Lackmy-ValléeA. PreuilhDavid DevosA.-S. RollandC. DesnuelleM. ChupinV. Marchand-PauvertG. QuerinPierre-François PradatLucette LacomblezJulie SochaFanny PineauTimothee LengletPatricia Doucelance Stéphanie FolhinhaAmandine BordetHugo RoyerNadia OsmanSabah Ait KhelifaPhilippe CorciaStephane BeltranDelphine CarmierLaurent BarantinHélène BlascoSalah Eddine BakkoucheMohad MouzouriJean-Christophe AntoineJean-Philippe CamdessanchéNathalie DimierAnne-Laure KaminskyIsabelle Court-FortuneClaire BoutetPhilippe GonzaloVincent VisneuxKarine FerraudGeorgette BerlierSteeve GenestetChristophe Gut-GobertDouraied Ben SalemPauline NicolasSabine LarvorKevin MoulyLiana Le RouxKevin PostecCamille BezeazuxSylvain RosecHélène Fortin-PrunierGaelle NovertElsa MenanteauKevin PostecMagali DenizotEmilien BernardChristophe VialEmmanuel BroussoleJuliette SvahnPierre Le CamYves BerthezenePhilippe CombetSophie JacquelineCamille NeuilletAdeline MansuyWilliam CamuSylvain LehmannSebastien AlphandryLaura LabarLeandra BaudessonSharam AttarianAude-Marie GrapperonJean PougetAnnie VerschuerenJaochim BasArmelle Finet-MonnierCarole BelingherSaran DialloNacime HeddadjiSebastien AlphanderyLeandra BaudessonPascale ReginensiClaude DesnuelleMarie-Hélene SorianiS. ChanaletLydiane MondotIsabelle PruvostCarole BarréPascal CintasMarie-Christine Arne BesBlandine AcketJérémie ParienteIsabelle GuilbaudFabrice BonnevilleE. CausseThierry LagardeJeremy GeffroyMagali CentellesVéronique Hermet-DouardSophie Pittion-VouyovitchMaud MichonMylène MeyerSandra LomazziGabriela HossuAnne ChatelainPhilippe CouratierGeraldine LautretteFrancois VincentLarie-Therese AntoniniFlorent FavardM. Boncoeur-MartelMarianne ChoulyJean-Claude DesportPierre JésusPhillipe FayemendyClémence LabetoulleJulie CatteauOlivier VilleneuveSelam MachatNathalie GuyPierre ClavelouAnick GreilMartine DuclosBetty JeanCarine ChassainCamille TsoutsosClaudine SpezialeAurélie CladiereC. BouteloupN. FarigonSophia Sickout ArgondoEmilie DumontSandrine RouvetFausto ViaderMathilde LefilliatrePhilippe MoutonA. MondouStéphane AlloucheRachida Bari-MakouriIvan KolevMorgane PihanHelene Le HoBertrand CatrouxMaela CastelMarine RigalCatherine BellotMaelle VomscheidMarie-Cécile HervéMarie-Pierre DubanAnne VieillartJulien CassereauPhilippe CodronVivien PautotNicole MeslierWojciech TrzepizurJ. TanguyPhilippe AllainCecile ThieryPascal ReynierTiphaine BarbeNathalie VienneAudrey OlivierJeanne MillerMarie BostDavid GayRobin BonicelFouzia El MountassirClara FischerJean-François ManginMarie ChupinYann CointepasBertrand AccartPatrick GeléFlorine FievetMatthieu ChabelVirginie DerenaucourtLoïc FaconYanick Tchantchou NjosseMichael HisberguesChristine TabuencaMarie-France CazalèrePhilippe CouratierWilliam CamuPhilippe CorciaClaude DesnuelleMaxime CaillierVéronique DanelCaroline MorerauVictor LaugeaisAmelie LecocqNathalie PotinMarie FrischMarie LéonDavid DevosFrançois SalachasPierre-Francois PradatLucette LacomblezJean-Philippe CamdessanchéSharam AttarianTimothée LangletHélène BlascoLuc DupuisMathilde BonEmilien BernardJulien CassereauMarie-Hélène SorianiCedric RaoulSylvain LehmanSabine TurgemanValérie Goutines
• Organismes : Plasticité cérébrale et adaptations des fonctions visuelles et motrices Centre de Référence Maladies Neuromusculaires et SLA Physiologie et physiopathologie de la motricité chez l'homme CHU Pitié-Salpêtrière [AP-HP] Laboratoire d'Imagerie Biomédicale [Paris] CHU Pitié-Salpêtrière [AP-HP] Laboratoire d'Imagerie Biomédicale [Paris] Lille Neurosciences & Cognition - U 1172
• Publié dans Journal of Neurology le 01/11/2020

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Résumé : Background Motor capacity is crucial in amyotrophic lateral sclerosis (ALS) clinical trial design and patient care. However, few studies have explored the potential of multimodal MRI to predict motor capacity in ALS. This study aims to evaluate the predictive value of cervical spinal cord MRI parameters for motor capacity in ALS compared to clinical prognostic factors. Methods Spinal multimodal MRI was performed shortly after diagnosis in 41 ALS patients and 12 healthy participants as part of a prospective multicenter cohort study, the PULSE study (NCT 2013-A00969-36). Motor capacity was assessed using ALSFRS-R scores. Multiple stepwise linear regression models were constructed to predict motor capacity at 3 and 6 months from diagnosis, based on clinical variables, structural MRI measurements, including spinal cord cross-sectional area (CSA), anterior–posterior, and left-to-right cross-section diameters at vertebral levels from C1 to T4, and diffusion parameters in the lateral corticospinal tracts (LCSTs) and dorsal columns. Results Structural MRI measurements were significantly correlated with the ALSFRS-R score and its sub-scores. And as early as 3 months from diagnosis, structural MRI measurements fit the best multiple linear regression model to predict the total ALSFRS-R (R2 = 0.70, p value = 0.0001) and arm sub-score (R2 = 0.69, p value = 0.0002), and combined with DTI metric in the LCST and clinical factors fit the best multiple linear regression model to predict leg sub-score (R2 = 0.73, p value = 0.0002). Conclusions Spinal multimodal MRI could be promising as a tool to enhance prognostic accuracy and serve as a motor function proxy in ALS.

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• Type de publi. : Article dans une revue
• Date de publi. : 26/04/2023
• Auteurs : Stephanie DramburgC. HilgerAlexandra SantosLeticia de Las VecillasRob AalberseNathalie AcevedoLorenz AglasFriedrich AltmannLuisa Karla ArrudaRiccardo AseroBarbara Ballmer-WeberDomingo BarberKirsten BeyerTilo BiedermannMaria Beatrice BiloSimon BlankPhilipp P. BosshardHeimo BreitenederHelen Annaruth BroughMerima BublinDianne CampbellL. CaraballoJean‐christoph CaubetGiorgio CeliMartin ChapmanMaksymilian ChruszczAdnan CustovicRebecca CzolkJanet DaviesNikolaos DouladirisBernadette EberleinMotohiro EbisawaAnna EhlersPhilippe EigenmannGabriele GadermaierMattia GiovanniniFrancisca GomezRebecca GrohmanCarole GuilletChristine HafnerRobert G. HamiltonMichael HauserThomas HawranekHans HoffmannThomas HolzhauserTomona IizukaAlain JacquetThilo JakobBente Janssen-WeetsUta JappeMarek JutelTanja KalicSandip KamathSabine KespohlJörg Kleine-TebbeEdward KnolAndré KnulstJon KonradsenPeter KorošecAnnette KuehnGideon LackThuy‐my LeAndreas LopataOlga LuengoMika MäkeläAlessandro Maria MarraE N Clare MillsMartine MorissetAntonella MuraroAnna Nowak-WegrzynRoni NugrahaMarkus W. OllertK. PalosuoElide Anna PastorelloSarita U PatilThomas Platts-MillsAnna PomésPascal PoncetEkaterina PotapovaLars PoulsenChristian RadauerSuzana RadulovicMonika RaulfPierre RougéJoaquin SastreSakura SatoEnrico ScalaJohannes Martin SchmidPeter Schmid‐grendelmeierDenise SchramaHélène SénéchalClaudia Traidl‐hoffmannMarcela Valverde-MongeM. van HageRonald van ReeKitty VerhoeckxStefan ViethsM. WickmanJosefina ZakzukPaolo Maria MatricardiKarin Hoffmann-Sommergruber
• Organismes : Charité - UniversitätsMedizin = Berlin University Medicine Luxembourg Institute of Health King‘s College London Guy's and St Thomas' Hospital [London] La Paz University Hospital Universiteit van Amsterdam = University of Amsterdam University of Cartagena Paris-Lodron-Universität Salzburg = Paris-Lodron-University of Salzburg Universität für Bodenkultur Wien = University of Natural Resources and Life Sciences [Vienne, Autriche] Universidade de São Paulo = University of São Paulo Clinica San Carlo [Milan, Italy] Brustzentrum Kantonsspital St.Gallen Universidad San Pablo CEU Red Temática de Investigación Cooperativa en Salud : Asma, Reacciones Adversas a Fármacos y Alérgicas [Spain] Red de enfermedades inflamatorias [Spain] Charité - UniversitätsMedizin = Berlin University Medicine Technische Universität Munchen = Technical University Munich = Université Technique de Munich Polytechnic University of Marche / Università Politecnica delle Marche University Hospital Ospedali Riuniti [Ancona, Italy] Technische Universität Munchen = Technical University Munich = Université Technique de Munich Helmholtz Zentrum München = German Research Center for Environmental Health University hospital of Zurich [Zurich] Medical University of Vienna = Medizinische Universität Wien King‘s College London Guy's and St Thomas' Hospital [London] Medical University of Vienna = Medizinische Universität Wien Sydney Children's hospital The University of Sydney University of Cartagena Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Azienda Socio Sanitaria Territoriale di Mantova [Mantova, Italy] InBio [Charlottesville, VA, USA] University of South Carolina [Columbia] Imperial College London Luxembourg Institute of Health Université du Luxembourg = University of Luxembourg = Universität Luxemburg Queensland University of Technology [Brisbane] Metro North Hospital and Health Service [Herston, Australia] National and Kapodistrian University of Athens Technische Universität Munchen = Technical University Munich = Université Technique de Munich Sagamihara National Hospital [Kanagawa, Japan] Universiteit Utrecht / Utrecht University [Utrecht] Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève] Paris-Lodron-Universität Salzburg = Paris-Lodron-University of Salzburg Azienda Ospedaliero Universitaria Meyer [Firenze] = Meyer Children's University Hospital [Florence] Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain] Red Temática de Investigación Cooperativa en Salud : Asma, Reacciones Adversas a Fármacos y Alérgicas [Spain] NYU Langone Health [New York] University hospital of Zurich [Zurich] Universität Zürich [Zürich] = University of Zurich Karl Landsteiner University of Health Sciences - Karl Landsteiner Privatuniversität für Gesundheitswissenschaften [Krems an der Donau, Austria] Johns Hopkins University School of Medicine [Baltimore] Paris-Lodron-Universität Salzburg = Paris-Lodron-University of Salzburg Paracelsus Medizinische Privatuniversität = Paracelsus Medical University Aarhus University [Aarhus] Aarhus University Hospital Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines Hokkaido University [Sapporo, Japan] Chulalongkorn University [Bangkok] Justus-Liebig-Universität Gießen = Justus Liebig University Luxembourg Institute of Health University of Southern Denmark = Syddansk Universitet Forschungszentrum Borstel, Leibniz Lungenzentrum - Research Center Borstel, Leibniz Lung Center [Sülfeld, Germany] German Center for Lung Research Universität zu Lübeck = University of Luebeck [Lübeck] Wrocław Medical University Medical University of Vienna = Medizinische Universität Wien Karl Landsteiner University of Health Sciences - Karl Landsteiner Privatuniversität für Gesundheitswissenschaften [Krems an der Donau, Austria] James Cook University Ruhr University Bochum = Ruhr-Universität Bochum [Bochum] Allergie- und Asthma-Zentrum Westend = Allergy and Asthma Center Westend [Berlin, Germany] Universiteit Utrecht / Utrecht University [Utrecht] Universiteit Utrecht / Utrecht University [Utrecht] Karolinska Institutet = Karolinska Institute [Stockholm] Karolinska University Hospital [Stockholm] University Clinic of Respiratory and Allergic Diseases Golnik [Golnik, Slovenia] Luxembourg Institute of Health King‘s College London Guy's and St Thomas' Hospital [London] Universiteit Utrecht / Utrecht University [Utrecht] James Cook University Red Temática de Investigación Cooperativa en Salud : Asma, Reacciones Adversas a Fármacos y Alérgicas [Spain] Red de enfermedades inflamatorias [Spain] Vall d'Hebron University Hospital [Barcelona] Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona Helsinki University Hospital [Finland] Helsingin yliopisto = Helsingfors universitet = University of Helsinki Azienda Socio Sanitaria Territoriale Rhodense [Milano, Italy] University of Manchester [Manchester] Centre Hospitalier Universitaire d'Angers Azienda Ospedale Università di Padova = Hospital-University of Padua New York University School of Medicine University of Warmia and Mazury [Olsztyn] James Cook University Bogor Agricultural University Luxembourg Institute of Health University of Southern Denmark = Syddansk Universitet Helsinki University Hospital [Finland] Helsingin yliopisto = Helsingfors universitet = University of Helsinki Casa di cura Ambrosiana = Ambrosiana Nursing Home [Milano, Italy] Harvard Medical School [Boston] Massachusetts General Hospital [Boston] University of Virginia InBio [Charlottesville, VA, USA] Département d'Immunologie - Department of Immunology CHU Trousseau [APHP] Charité - UniversitätsMedizin = Berlin University Medicine Copenhagen University Hospital [Denmark] = Københavns Universitetshospital [Danmark] Medical University of Vienna = Medizinische Universität Wien King‘s College London Guy's and St Thomas' Hospital [London] Ruhr University Bochum = Ruhr-Universität Bochum [Bochum] Pharmacochimie et Biologie pour le Développement Universidad Autónoma de Madrid National and Kapodistrian University of Athens Istituto di Ricovero e Cura a Carattere Scientifico Istituto Dermopatico dell’Immacolata Fondazione Monti [Roma, Italy] Aarhus University Hospital University hospital of Zurich [Zurich] Christine Kuhne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland Universidade do Algarve - University of Algarve CHU Trousseau [APHP] Christine Kuhne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland Universität Augsburg [Deutschland] = University of Augsburg [Germany] = Université d'Augsbourg [Allemagne] Hospital Universitario Fundación Jiménez Díaz [Madrid] Karolinska Institutet = Karolinska Institute [Stockholm] Karolinska University Hospital [Stockholm] Universiteit van Amsterdam = University of Amsterdam Universiteit Utrecht / Utrecht University [Utrecht] Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines Karolinska Institutet = Karolinska Institute [Stockholm] University of Cartagena Charité - UniversitätsMedizin = Berlin University Medicine Medical University of Vienna = Medizinische Universität Wien
• Publié dans Pediatric Allergy and Immunology le 02/11/2020

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Résumé : Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

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Fichiers liés : DRAMBURG_2022.pdf

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