Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Maud RobertTigran PoghosyanNicolas Romain-ScelleSebastien CzernichowDominique DelaunayAdrien SterkersLitavan KhamphommalaAndrea LazzatiClaire BlanchardRobert CaiazzoFrançois PattouEmmanuel DisseCaroline GronnierFabian RechePhilippe TopartJean-Louis LorinPhilippe RaffaitinNelson TrellesIole SicilianoLaurent BrunaudDaniel KrawczykowskiGéraud TuyerasAdriana TorciviaElise PelasciniBérénice SégrestinCarole Langlois-Jacques
• Organismes : Hospices Civils de Lyon Centre de recherche sur l'Inflammation Hospices Civils de Lyon Université Claude Bernard Lyon 1 Département biostatistiques et modélisation pour la santé et l'environnement [LBBE] Biostatistiques santé [LBBE] Service de Biostatistiques [Lyon] Hôpital Européen Georges Pompidou [APHP] Hospices Civils de Lyon Centre Hospitalier Privé Saint-Grégoire [Saint-Gregoire] Centre Hospitalier Privé Saint-Grégoire [Saint-Gregoire] Sciences de l’information au service de la médecine personnalisée Sciences de l’information au service de la médecine personnalisée Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Régional Universitaire [CHU Lille] Centre Hospitalier Lyon Sud [CHU - HCL] Cardiovasculaire, métabolisme, diabétologie et nutrition French-Clinical Research Infrastructure Network / F-CRIN [Lyon] Université de Bordeaux Centre Hospitalier Alpes Isère [Grenoble, France] Centre Hospitalier René Dubos [Pontoise] Centre Hospitalier Régional Universitaire de Nancy Centre Hospitalier Universitaire de Toulouse Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon
• Publié dans The Lancet le 02/11/2020

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Résumé : Abstract Background hPG 80 (circulating progastrin), initially recognized for its oncogenic properties due to its direct link to the Wnt signaling pathway, is secreted by cancer cells and detectable in the blood of cancer patients. The ONCOPRO centralized case-control study (NCT03787056) was designed to prospectively evaluate the diagnostic utility of hPG 80 in patients with 16 different types of cancer. Methods hPG 80 levels were measured in 421 patients with 16 newly diagnosed cancers (median age 65.6 years old) using the DxPG80.Lab kit (Biodena Care). The diagnostic performance of hPG 80 (the primary endpoint) was assessed by comparing baseline hPG 80 levels in cancer patients with those of 330 asymptomatic aged-matched healthy subjects from the general population. Results Between 2018 and 2022, a total of 506 cancer patients were enrolled in the study, with 421 assessable across 16 distinct cancer cohorts. hPG 80 concentrations were significantly higher in cancer patients compared to the healthy population (median 3.8 [IQR: 1.0-11.1] vs. 1.9 [IQR: 0.6–4.2] pM, P < 0.0001). hPG80 levels were not impacted by renal failure, liver dysfunction, or cancer-associated inflammation. The diagnostic accuracy in cancer patients was ROC AUC 0.63, 95% CI = [0.59–0.67]. The highest diagnostic accuracy was seen in patients with lung cancer (AUC 0.75, 95% CI [0.68–0.82]; specificity = 88% for hPG 80 > 7.73 pM in patients aged > 58 years old) and hepatocellular carcinoma HCC (ROC AUC 0.75, 95% CI [0.66-083]; specificity = 88% for hPG 80 > 7.73 pM in patients aged > 58 years old). Conclusions This large prospective study confirms that cancer patients have significantly higher hPG 80 blood concentration compared to the healthy population. Incorporating this straightforward ELISA assay into screening programs is warranted. Trial registration NCT03787056.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Patrick RossignolFaiez ZannadZiad MassyMichel AziziFatima ChorfaJulien CoadicJoão Pedro FerreiraFrancisca SaraivaDominique MottierF. GuilleminWilly Ngueyon SimeSanae BoualiBénédicte RossignolJoëlle NortierIsabelle SimonChristophe RobinoManuela DavinPierre BatailleFrançois ChantrelNelly CastinVincent EsnaultIsabelle KazesThierry HannedoucheNassim KamarJean-Michel AchardCaroline FenerolCarine Achard-HottelartYves DimitrovNicolas GirerdDelphine Maucort-BoulchLuc FrimatJean-Michel AchardCarine Achard HottelartDidier AguileraAsma AllaVincent AllotMahmoud AllouacheWalid ArkoucheMichel AziziDaniela BabiciNolwenn Bacle-RabotJean-Louis BacriAurore BarthelemyGrégoire BassePierre BatailleStanislas BatailleDorothée Bazin-KaraClémence BechadeStefanie BeierLarbi BencheikhJean-Christophe BendiniValérie BetzPascal BindiBéatrice BirmeleVincent BisacciaLaurène BlacherFrédérique BocquentinClaire Borni DuvalAlexandra BotteSanae BoualiJulien BouetRehouni BoulahrouzFranck BourdonAntoine BraconnierPhilippe BrunetFlora BrunnerThanh Cao-HuuClaire CarteryNelly CastinEtienne CellotJean-Marc ChalopinJacques ChanliauFrançois ChantrelMarion ChapalChristophe CharasseEmmanuelle CharlinVianney CharpyFatima ChorfaGabriel ChoukrounPierre ClavelJulien CoadicJean-Marie CoulibalyGrégoire Couvrat-DesvergnesJoëlle CridligRomain CrochetteGéraldine d'YthurbideMaite DarouxManuela DavinGéraldine de Geyer d'OrthLouis de LaforcadeMelanie DecambronVincent DelattreArnaud DelbelloCatherine DelcroixCarole DepreleJonathan DesprezNadège DevillardMohamed Diab MahoumoudZara DicksonYves DimitrovThibault Dolley-HitzePatrick DonnadieuAriane Duval-SabatierNajeh El EsperRocsana Maria EnacheLaure EprinchardVincent EsnaultMarie EssigFadi FakhouriCaroline FenerolInès FerrandizHafedh FessiMaxence FicheuxDominique FleuryNans FlorensDenis FouqueJacques FourcadeCaroline FreguinMarie FrimatAntoine GarstkaJulien GayonEtienne GedSandrine GenestierLora GeorgievaLila Ghouti TerkiPhilippe GiaimeBrigitte GilsonFrançois GlowackiBertrand GondouinMorgane GosselinClément GossetMarlène GoubetAnne GrallMary-Jane GuerryThomas GuincestreAtman Haddj ElmrabetThierry HannedoucheAbraham HaskourDelphine HebmannPatrick HenriNathalie Housieux-MaisonneuveAurélie HummelManfred IsmerJean-Paul JaulinMaité JaureguyAnne JolivotLaurent JuillardEmilie KalbacherNassim KamarIoannis KaterinisIsabelle KazesAlexandre KleinEmmanuelle KohlerLaetitia KoppeGeorges KosmadakisMarc KribsMarie-Jeanne Krier-CoudertThierry KrummelKristian KunzManon LaforetAntoine LanotEric LaruelleFrédéric LavainneOlivier LavelleMaurice LavilleAwena Le FurMathilde Le JeuneOphelie Le Maner-JolibertYannick Le MeurCéline LebasMathieu LegendreEric LegrandCécile LemoineEmilie LeonCelia LessoreBénédicte LevyMarie Lino-DanielMehadji MaazJean-Michel MarcFranck MarechalZiad MassyDelphine Maucourt BoulchFrancois MaudDelia MayBruno Constant MbanLucile MercadalRafik MesbahQuentin MeuldersPierre-Antoine MichelDavid MilongoNadége MingatPhilippe MirgaineThibault MolesMatthieu MongeDominique MottierClément MottolaIgnace MpioSonia MzoughiWilly Ngueyon SimeJoëlle NortierMathilde NouvierTimothée NussbaumerAchille OkambaAdriana Opris-SaveanuJulien OttJean-Noel OttavioliSophie ParahyMyriam PasturalCaroline PelletierSolenne PelletierFranck PerrinNicolas PetersAndreea PetrachePierre PeyronnetJacky PotierCoralie PoulainLise-Marie PouteauEric PrinzFrançois ProvotGuillaume QueffeulouAnne-Hélène QuerardCéline Quintard-LacourJean-Michel RebibouEric RenaudineauMarianne RenouChristine RicherChristophe RidelPhilippe RieuChristophe RobinoLionel RostaingHaiat Salloum-BittarJérôme SampolFrancisca SaraivaViolaine ScarfogliereElise ScheidtAdeline SchendelPascale SebahounIsabelle SegalenAude ServaisIsabelle SimonAmélie SimonHenriette SissokoAlexandra StancuJean-Christophe SzelagAline TalaszkaTugdual TanquerelNatalia TargetAngelo TestaClaire TinelJérémi TitusElisabeth TomkiewiczMaxime TouzotPierre TrollietZead TubailHenri-Bernard Vacher-CoponatSophie VallanceAnne-Sophie VasseurCaroline VercelDavid VerhelstGuillaume VerninNicolas VialletSando VidoCécile VigneauEmmanuel VillarClarissa von KotzePhilippe Zaoui
• Organismes : Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] Centre Hospitalier Princesse Grace Monaco Private Hemodialysis Centre M-CRIN (Monaco Clinical Research Infrastructure Network) Association Lorraine pour le Traitement de l'Insuffisance Rénale Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations AURA [Paris] CIC - HEGP Hôpital Européen Georges Pompidou [APHP] Service de Biostatistiques [Lyon] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Groupe d'Etude de la Thrombose de Bretagne Occidentale Clinique d'Investigation Clinique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Défaillance Cardiovasculaire Aiguë et Chronique Universidade do Porto = University of Porto RISE-Health Universidade do Porto = University of Porto RISE-Health Groupe d'Etude de la Thrombose de Bretagne Occidentale Clinique d'Investigation Clinique Centre Hospitalier Régional Universitaire de Brest INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique - Epidémiologie clinique [Nancy] Centre d'investigation clinique [Nancy] Centre Hospitalier Régional Universitaire de Nancy Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] French COVID cohort study group Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Faculté de Pharmacie [Bruxelles] Hôpital Erasme = Erasmus Hospital = Erasmus Ziekenhuis Centre Hospitalier Universitaire Brugmann [Bruxelles] Laboratoire Microorganismes : Génome et Environnement Centre Hospitalier Universitaire Brugmann [Bruxelles] Hôpital Princesse Grace [Monaco] Monaco Private Hemodialysis Centre M-CRIN (Monaco Clinical Research Infrastructure Network) Hôpital Princesse Grace [Monaco] Monaco Private Hemodialysis Centre M-CRIN (Monaco Clinical Research Infrastructure Network) Centre Hospitalier Boulogne-sur-mer Association pour l'Utilisation du Rein Artificiel Région Lyonnaise Université de Lorraine Association Lorraine pour le Traitement de l'Insuffisance Rénale Département de Néphrologie - Hôpital Pasteur [Nice] Centre Hospitalier Universitaire de Nice Hôpital universitaire Robert Debré [Reims] Association pour l'Utilisation du Rein Artificiel Région Lyonnaise Centre Hospitalier Universitaire de Toulouse Institut Toulousain des Maladies Infectieuses et Inflammatoires Pharmacologie des Immunosuppresseurs et de la Transplantation Service de Néphrologie, Dialyse, Transplantations [CHU Limoges] Centre d'Investigation Clinique de Limoges ALURAD Centre Hospitalier de Haguenau Association pour l'Utilisation du Rein Artificiel Région Lyonnaise Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Défaillance Cardiovasculaire Aiguë et Chronique Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon Service de Biostatistiques [Lyon] Service de Néphrologie [CHRU Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Pharmacologie des Immunosuppresseurs et de la Transplantation Centre Hospitalier Jacques Lacarin Service de Néphrologie [CHRU Nancy] CHU Limoges Association pour l'Utilisation du Rein Artificiel Région Lyonnaise CIC - HEGP Hôpital Européen Georges Pompidou [APHP] Université Grenoble Alpes Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Université de Lorraine Association pour l'Utilisation du Rein Artificiel Région Lyonnaise Service de Biostatistiques [Lyon] Hôpital Ambroise Paré [AP-HP] Centre de recherche en épidémiologie et santé des populations AURA [Paris] Groupe d'Etude de la Thrombose de Bretagne Occidentale Clinique d'Investigation Clinique Centre Hospitalier Régional Universitaire de Brest Centre d'investigation clinique [Nancy] Centre Hospitalier Régional Universitaire de Nancy Faculté de Pharmacie [Bruxelles] Department of Nephrology - Dialysis and Renal Transplantation Histoire et Sources des Mondes antiques Universidade do Porto = University of Porto Laboratoire Microorganismes : Génome et Environnement
• Publié dans The Lancet le 02/11/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Marta CimadevilaJunke LiuDamien MaurelIsabelle BrabetMarine HoscarJulia DrubeCarsten HoffmannAsuka InouePhilippe RondardPierre-André LafonLaurent PrézeauJean-Philippe Pin
• Organismes : Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Friedrich-Schiller-Universität Jena = Friedrich Schiller University Jena = Université de Iéna [Jena, Germany] Friedrich-Schiller-Universität Jena = Friedrich Schiller University Jena = Université de Iéna [Jena, Germany] Tohoku University [Sendai] Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle Institut de Génomique Fonctionnelle
• Publié dans Cell Reports le 30/10/2020

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Résumé : Cell surface G protein-coupled receptors (GPCRs) are tightly regulated through constitutive and agonist-induced internalization. While the mechanisms of constitutive internalization remain elusive, agonist-induced internalization very often involves receptor phosphorylation by GPCR kinases (GRKs) and β-arrestin recruitment. Dimeric class C metabotropic glutamate (mGlu1-mGlu8) receptors regulate synaptic transmission, but their internalization process remains ambiguous. Here, using diffusion-enhanced energy transfer (DERET), we show that mGlu receptors undergo constitutive internalization that mostly relies on β-arrestins. However, only mGlu1, mGlu5, and mGlu3 homodimers and mGlu2-3 heterodimers undergo agonist-induced internalization. This process depends on protein adaptor complex 2 (AP2) but still occurs in the absence of GRKs or β-arrestins, with the latter acting as fine-tuners. This systematic study further highlights how class C receptors differ from other GPCRs, revealing non-canonical internalization mechanisms that remain to be characterized. These insights into mGlu receptor dynamics will contribute to the development of therapeutic strategies targeting mGlu receptors.

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Fichiers liés : Cimadevila et al 2025.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Antoine GavoilleEmmanuelle LerayRomain MarignierFabien RollotRomain CaseyGuillaume MatheyLaure MichelJérôme de SèzeJonathan CironAurélie RuetElisabeth MaillartPierre M LabaugeHélène ZéphirDavid-Axel LaplaudCaroline PapeixGilles-Louis DeferThibault MoreauEric BergerAnne-Laure DubessyPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierAbdullatif Al KhedrOlivier CasezBertrand BourreAbir WahabLaurent MagyJean-Philippe CamdessanchéInès DoghriSolène MoulinCéline LabeyrieKarolina HankiewiczAmélie dos SantosCorinne PottierÉric ManchonMaya TchikviladzeChristine Lebrun-FrénaySandra VukusicLucie Bellon-TabartDelphine CortialFrançois CottonF. GuilleminJavier OlaizBruno StankoffEmmanuelle Le PageNicolas CollonguesArnaud KwiatkowskiSandrine WiertlewskiClaire GiannesiniBertrand AudoinPhilippe CabrePierre DurozardBertrand LapergueChantal NifleJérôme Grimaud
• Organismes : Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Hospices Civils de Lyon École des Hautes Études en Santé Publique Recherche sur les services et le management en santé Arènes: politique, santé publique, environnement, médias Département Méthodes quantitatives en santé publique Université de Rennes Hospices Civils de Lyon Université Claude Bernard Lyon 1 Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Service de neurologie [CHRU Nancy] INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Centre d'investigation clinique - Epidémiologie clinique [Nancy] Service de Neurologie [Rennes] = Neurology [Rennes] Centre d'Investigation Clinique [Rennes] CIC Strasbourg Service de Neurologie [Strasbourg] Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Institut Toulousain des Maladies Infectieuses et Inflammatoires Service de neurologie [Bordeaux] Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale CHU Pitié-Salpêtrière [AP-HP] CHU Montpellier = Montpellier University Hospital Université de Montpellier Lille Neurosciences & Cognition - U 1172 Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology CIC Plurithématique de Nantes Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université de Caen Normandie Service de Neurologie [CHU Caen] Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Service de Neurologie [CHRU Besançon] CHU Pitié-Salpêtrière [AP-HP] Neuro-Dol Service Neurologie [CHU Clermont-Ferrand] Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Service de neurologie [Amiens] Pôle Psychiatrie et Neurologie [Grenoble] Translational Research in Autoimmunity and Inflammation Group Service de neurologie [Rouen] Hôpital Henri Mondor Service de Neurologie [CHU Limoges] Service de Neurologie [CHU de Saint-Étienne] Hôpital Bretonneau Service de neurologie [Reims] Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre] Centre Hospitalier de Saint-Denis [Ile-de-France] Service de neurologie [CHU de Poitiers] Centre Hospitalier René Dubos [Pontoise] Centre Hospitalier de Gonesse Hôpital Foch [Suresnes] Hôpital Pasteur [Nice] UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Hospices Civils de Lyon Université Claude Bernard Lyon 1 Observatoire Français de la Sclérose En Plaques [Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation Eugène Devic EDMUS
• Publié dans Neurology le 01/11/2020

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Résumé : Background and objectives: In women with multiple sclerosis (MS), the therapeutic strategy may be influenced by the anticipation of future pregnancies, leading to underexposure to disease-modifying therapies (DMTs) and highly effective DMTs (HEDMTs) compared with men. We aimed to evaluate potential therapeutic inertia in women with MS and explore its causes. Methods: We performed a retrospective cohort study based on data extracted on June 2023 from the Observatoire Français de la Sclérose en Plaques for all patients with a relapsing-remitting MS onset between 18 and 40 years. The primary outcome was the annual probability of receiving a DMT, accounting for sex, disease severity, and pregnancy/postpartum periods. Secondary outcomes were the annual probability of receiving a HEDMT, each DMT separately, and interaction of the effect of sex with calendar year, patient age, and disease duration. We used a longitudinal logistic model with generalized estimating equations and an inverse-probability-of-censoring weighting. Results: We included 22,657 patients with MS; 16,857 (74.4%) were female, mean (SD) age at onset was 29.0 (6.0) years, and median (interquartile range) follow-up duration was 11.6 (6.6-17.3) years. Women were significantly less likely to receive a DMT (odds ratio [OR] 0.92, 95% CI 0.87-0.97) or a HEDMT (OR 0.80, 95% CI 0.74-0.86). This difference appeared 2 years after disease onset for DMTs and 1 year for HEDMTs, and did not differ significantly according to patient's age. Teriflunomide, sphingosine-1-phosphate receptor modulators, and anti-CD20s were significantly underused in women throughout their entire period of availability; interferons β (IFN-β) and natalizumab were initially less used and then equally after some time; glatiramer acetate and fumarates were first used equally, then more frequently in women. The proportion of treated women, analyzed from the first childbirth of 5,268 women, began to decline 18 months before childbirth, from 42.6% to 27.9% at the estimated time of conception. Discussion: Women with MS were significantly less exposed to DMTs compared with men. Anticipation of pregnancy was probably an important factor underlying this difference, but also sex-specific therapeutic inertia. Neurologists and patients should be educated on the most recent recommendations on the use of DMTs in the context of pregnancy to avoid deleterious therapeutic inertia.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Nicolas BourgonTina LüdeckeJennifer N LeichliterChris BaumannSven BrömmeMarissa VinkAnne-Marie BaconJeremy MccormackThi Mai Huong NguyenAnh Tuan NguyenPierre-Olivier AntoineJean-Luc PonchePhilippe DuringerFabrice DemeterSouliphane BoualaphaneThonglith LuangkhothElise DufourJean-Jacques HublinKlervia JaouenThomas TütkenAlfredo Martínez-GarcíaPatrick Roberts
• Organismes : Max Planck Institute for Geoanthropology = Max-Planck-Institut für Geoanthropologie Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Max Planck Institute for Chemistry Max Planck Institute for Chemistry Max Planck Institute for Chemistry Eberhard Karls Universität Tübingen = University of Tübingen Max Planck Institute for Chemistry Max Planck Institute for Chemistry Biologie, anthropologie, biométrie, épigénétique, lignées : De la diversité des populations à l'individu, de l'identification à l'identité Goethe University Frankfurt = Goethe-Universität Frankfurt am Main Institut des Sciences de l'Evolution de Montpellier Université de Montpellier Laboratoire Image, Ville, Environnement Institut de physique du globe de Strasbourg Ecole et Observatoire des sciences de la terre University of Copenhagen = Københavns Universitet Université Paris Cité Archéozoologie - Archéobotanique. Sociétés, pratiques et environnements Collège de France - Chaire Paléoanthropologie Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Géosciences Environnement Toulouse Max-Planck-Institut für evolutionäre Anthropologie = Max Planck Institute for Evolutionary Anthropology Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University Max Planck Institute for Chemistry Max Planck Institute of Geoanthropology
• Publié dans Science Advances le 21/10/2020

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Résumé : Southeast Asia boasts some of the world's most diverse ecosystems, yet it has experienced a dramatic decline in biodiversity due to extensive deforestation in recent decades. Understanding how species adapted to past habitat loss could provide valuable insights for developing effective conservation strategies to address current threats. We apply state-of-the-art isotope measurements of enamel-bound zinc (δ⁶⁶Zn) and nitrogen (δ¹⁵N enamel ) analyses to fossil mammal teeth from Coc Muoi [148 to 117 thousand years (ka) and Duoi U'Oi (70 to 60 ka)], Vietnam. Alongside published regional data (δ⁶⁶Zn, δ¹³C, and δ¹⁸O), we explore how different taxa adapt their diets and behaviors in the face of climatic and environmental changes. We show that foraging in diverse habitats and diversifying food consumed is associated with extant species, while extinct or locally extirpated taxa show these traits to a lesser extent. We underscore the precariousness of certain species and the pressing need for robust conservation policies to safeguard Southeast Asia's biodiversity.

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Fichiers liés : Bourgon2025SciAdv.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Faiez ZannadChristopher M O'ConnorJaved ButlerCiaran J McmullanKevin J AnstromIrina BarashMarc P BonacaMaria BorentainStefano CordaDavis GatesJustin A EzekowitzAdrian F HernandezCarolyn S P LamEldrin F LewisJoann LindenfeldRobert J MentzPiotr PonikowskiYogesh N V ReddyGiuseppe M C RosanoClara SaldarriagaMichele SenniPedro P TeixeiraJames UdelsonAlessia UrbinatiVanja VlajnicAdriaan A VoorsAiwen XingMahesh J PatelPaul W ArmstrongBurkert PieskeJoerg KoglinLothar RoessigKris ReayLisa SoulardTracy TempleCynthia WesterhoutConstance HamlinRhonda LovettNicholas RyanRobert BlausteinGregory GolmGang JiaChristi KentJaco de KlerkChristina SalernoSabine Broeker-ZweeringRichard NkulikiyinkaElaine WuKatharina MuellerElisabeth Pieske-KraigherMartin KropfRaymond J KimMichele ParkerSebastian KelleJeanette Schulz-MengerChristopher DefilippiRachel BellPalak ShahPeter ShawMichael LassmanFrank KramerRobert ChristensonDaniel MarkLinda Davidson-RayM. Cecilia BahitDavid M KayeDiana BondermanAnne-Catherine PouleurEdimar A BocchiFernando LanasJian ZhangVojtěch MelenovskýJens RefsgaardJohan LassusAlain Cohen-SolalFrank EdelmannDimitrios N TziakasJuan Luis Arango BeneckeDavid SiuEbrahim NooriKenneth McdonaldBasil S LewisMichele EmdinHiroyuki TsutsuiImran Zainal AbidinJorge EscobedoArend MosterdRichard W TroughtonDan AtarArmando Lionel Godoy PalominoEugenio B ReyesJose B Vazquez-TanusMyeong-Chan ChoYury LopatinDavid SimKaren Sliwa-HähnleJosé López-SendónLars H LundChern-En ChiangM. Ali OtoMartin CowieMichael M GivertzIleana L PiñaNancy K. SweitzerJohn J.V. McMurrayChristopher B GrangerThomas D CookGary S FrancisKarl SwedbergHaley HedlinG. Michael FelkerW. Schuyler JonesKaren P AlexanderSana M Al-KhatibKeith E DombrowskiRobert W HarrisonRenato D LopesRobin MathewsThomas J PovsicMatthew T RoeSreekanth VemulapalliEduardo Roque PernaMaria Galarza SalazanIgnacio MackinnonFlorencia EdenLuis CartasegnaViviana NovasHugo A LuquezAna CenciMiguel Angel HominalMaria Veronica BianchiniRodolfo Andres Ahuad GuerreroAndrea Alvarez D AmelioCarlos Alberto PoyMaria PoyClaudio R MajulCecilia CurraoEzequiel Hector VotteroMariana PerrinCesar Javier ZaidmanMaria Vanesa EspinosaGerardo ZapataLuciana AriasSonia Angelica SassoneLucas TonelliDaniel Agustin Chirino NavartaMaria ManginiJesus CuadradoPaula BordoniDavid M KayeKaye CarterJohn AmerenaToni ShanahanScott MckenzieKathryn StibijlCarmine de PasqualeFiona WollastonDavid Martin ColquhounAntonio Ferreira-JardimAlicia ChanGreer DymmottBrendan McquillanKatayun MohammadiDavid CrossJudy JeffreyAndrew SindoneMagdalena GebranAmit ShahGill TullochMaged WilliamBets ConwayJames WongDonna NorthDirk von LewinskiKarin BrandnerUta HoppeKristen KoppRegina Steringer MascherbauerClaudia SteinkellnerChristina BinderChristopher AdlbrechtMaria LeitgebFlorence SinnaeveMatthias DupontCarola ClaesMichel de CeuninckEls VancayseelePhilippe TimmermansGregory van GenechtenPierre TroisfontainesMireille MassozThao Thanh HuynhCaroline BoudreaultEric SabbahIsabelle ChausseRonald Leonard BourgeoisKaren BoydMichael HeffernanMarie BirchMarie-Claude ParentHelene BrownA. Shekhar PandeyTatiana BallivianNadia GiannettiReza SahebjameiSaul VizelBeverley FoxDennis Wayne RupkaSandi ThiessenChristian ConstanceMarie-France GauthierQuentin KushnerikAllan SchafferWendy JanzMichael ChanJennifer KnightSerge LepageDaniel SoucyJohn D ParkerElaine HsuLisa MielniczukErmina MogaBenoit CoutuJulie FleuryPaul MacdonaldKathleen HinesDiego DelgadoNatalia NugaevaYing SiaIsabelle RoyDavid LaflammeChristel SimardGilbert GosselinKatia DrouinBrian ClarkeKimberley RonakDenis SaulnierMelissa CoteBruce Alexander SussexBernadette DrukenMiroslaw RajdaJayne FalkenhamAshok MukherjeeBeverly BozekGordon Willy Pak Ling MoeCarlos FernandoSebastien BergeronHugo TremblayMarcelo Coelho ShibataBonnie WoloschukDante ManyariTracy ClevelandFrank NigroCrystal ForsythAnnie RoyHelene BolducDanielle DionNancy GilbertJames Y ChaJudy OtisMelinda BarabasMarie-Josee ChartrandVictor AssefAndrea EikhofManuel Novajas BalboaCarla Belen Aravena VasquezJuan Carlos Prieto DominguezViviana NoriegaPatricio YovaninizMarcela GrandonJessica HidalgoYuhui ZhangJing DongHaiying DaiYing XiaoTingbo JiangLin ShiJiyan ChenPeiyu HeDaoquan PengFangmei QingBiao XuRuihong WangXiang GuMin WangZhuhua YaoYing ChenPeizhi MiaoZhenfei ChenHui LiDongyan HuangQing YangXuefang YuAidong ShenXin ZhangXiaohui LiuQiang LvYugang DongDan LiuJingfeng WangHuijun OuyangChengchun TangYong ChenHui GongDandan TengJing YanLinying XuWeihong JiangXiaowei ZhouGuosheng FuYing ZhengShuyang ZhangLihong XuZhenyu YangChenying WuXiumin HanYuxia WangJing YuQiongying WangLihong WangLili ZhengWei JinNan ZhangChuanhuan ZhangXiaojian SunYali YaoPeng LeiZhaofen ZhengJunkui WangFengling MaMingzhi LongSulan WangHong ZhangMingmei GuoManhua ChenYayun WangZhanquan LiRuili DuanZuyi YuanTiaotiao LiYibin MeiLinyan YeZhouqing HuangXingyuan ZhangWenling LiuLei LiRuiping ZhaoJie GongDongqing ZhangJiahui ZhuChengjian YangChunxia WangZheng JiGao XinpeiXia MeiMingyun LiuPaula Garcia AmayaWilder Castano OsorioMaria DussanFranklin Roberto Quiroz DiazYuleth PradaCarlos Francisco Jaramillo MunozAna ZapataMonica JaramilloSolmara BelloRodrigo BoteroSandra SalazarMonica Lopez ParejaClaudia MoraNicolas Ignacio Jaramillo GomezJuan Camilo GarciaFabian TorresMiguel Alfredo MoncadaLaura Velez GilJaime Andres TorresYolanda LievanoVojtěch MelenovskýMiroslava KrausovaJan MalikMartin HajslKaterina MalaJan F VojacekJana FridrichovaFilip MalekDana RihovaVladimir CechLenka MasarikovaVilma MachovaJindrich SpinarJan MachaLibor NechvatalKenneth EgstrupLene MoltrupBenedikte HaastrupCamilla JespersenOle NyvadLene TanggaardLars FogPauline JohansenHenrik WiggersKristine Serup-HansenJens Due LomholdtKari NiemannOlav Wendelboe NielsenElisa StokholmMustafa TaskiranLotte Ring PedersenKai NymanTiina SankariHeikki UkkonenTuija VasankariSari KaresvuoriMiguel Vazquez IbarraKarim GalloujAngelique LombartThibaud DamyMounira KarhoubiMichel GalinierNathalie RosoliGuillaume TaldirMaelle VomscheidJean-Michel TartiereCharline GeninMuriel SalvatDelphine PolletBernard CitronOuarda LamallemNicolas GirerdLydie PoinsignonFrancois JourdaEmmanuelle MougenotHatem BoughanmiHanane FodilLionel BenhamouGhania HarziStefan StörkAnja KnoppeKarl-Friedrich AppelPetra BeckerJohann BauersachsManuela GeyerEkkehard SchmidtKristina SchmidtSophia StrempelDaniel BeugMichael BruderMichael JeserichMariana RupprechtHendrik HaakeBianca Krug-HoerenAndreas HagenowAnja KuntzschMirjana Vojvodic-MayerRonny LuxThomas HoracekManuela Pluemer-SchmidtMarkus KnappEdith Suepple-PochVeselin MitrovicAnnerose PeilStephan RosenkranzSusanne Roelle-HoehneRaffi BekeredjianIna ProbstIzabela TuletaMarjo LauterbornBernhard WinkelmannLinda TenbuschWolfgang ZehSandra EbleMirjam KesslerUta DichristinLars MaierEsther KellnerDimitrios N TziakasGeorgios ChalikiasFilippos TriposkiadisMichalis PapamichalisJohn ParissisVasiliki BistolaHaralampos KarvounisGeorgios GiannakoulasDimitrios TousoulisChristina ChrysohoouKaterina NakaAnna KotsiaPablo Carlos Montenegro ValdovinosMayra AguilarRonaldo A Gonzalez OrellanaEster MeléndezLissette Garcia de KrumbachEdgar Rolando RodríguezKarla BarreraMynor Adolfo Aguilar VásquezChung Wah David SiuVenus San Lui HoPui-Wai Alex LeeXue Ting WangKatherine FanEva TamGyongyver Ibolya MihalyAkos KalinaAnita SzaboSandor KanczIstvanne HentzelFerenc LakatosKrisztina TothBela MerkelyLaura DzsidaAttila PalinkasSzilvia Rostasne TothMarianna SvabBalazs Bugarin-HorvathRobert J KirschnerRozsa Toth KarolyneJoanne MaherRoss MurphyMary HallNiall MahonElaine GilroyBrendan McadamDavid FarrellJames O NeillCiara BlaineShaul AtarRita NadafTony HayekMira HassanLena ZarachovskyMichael ShochatIlana AloniAbid AssaliElena TsirulnikovWadi KinanyJanna EtkinTuvia Ben GalHadas Even NirYaron ArbelAdi Katalan ShaniElias MazenGilat Ron AvrahamSorel GolandAnastasia SuzdalnizkiMajdi HalabiIlana PortnovTal HasinAstrid RojanskyRafat JabaraGalina LevinAmos KatzOrna TubulGil MoravskyIra LapidusMarilisa AmbrosioClaudio PassinoAlessandra GabuttiLaura ScelsiEleonora VulloPaolo MidiAnna FeliciAlessandro FuciliMaria SarconeSavina NodariLaura LupiVitaliano SpagnuoloMaurizio VolterraniValentina MorsellaSimona Sarzi BragaRaffaella VaninettiPiergiuseppe AgostoniElisabetta SalvioniStefano TaddeiRosa Maria BrunoGianfranco ParatiCarlotta MunfortiRosanna LaucielloStefano CoiroAndrea MortaraSimone MazzettiGianfranco SinagraFederica RamaniAlessandra GualcoSimona CattaneoGiuseppe ArgiolasWanda MasalaFranco CosmiBeatrice MariottoniAkihiro NakamuraKazumi FutonoTatsuya KomaruTomoko EndoShigeru FukuzawaYumi NakamuraYasuo OkumuraHaruka SatoHirotsugu TabataMizuki SainoTakanori IkedaReiko KaminishiMio EbatoAkiko FukatsuTakahiko AoyamaChihiro KitaniHiroki SakamotoKaori AmanoTomoaki SaekiKayo ShimanoKenji KadaYoko TsuzukiTetsuo HashimotoMadoka OkamotoKenshi FujiiMari TsujimotoTahei IchinoheSaori OkabeKeiji HirookaYuna SenshuTetsuro OhtaTomomi HayashiYusuke KawaiJuri HorioAtsushi TakaishiMikiko NakamuraHiroyuki TakatsuTomoko ShiotaKoji MaemuraMomoyo NishidaYoshisato ShibataKaori NagashimaTaro ShibasakiNobue TakahashiHarukazu IsekiKenichi OtsukiShunzo MatsuokaKentaro MotodaYoshiharu HiguchiHiromi HayasakiMamoru ManitaRiyo ItoMasahiro SuzukiKaori FumikuraHiroshi IwataKaori KinjoEiki TakimotoYuki OmoriKazuhiko YumotoJun YoshizawaChisato IzumiKanae HiraseShinichi HigashiueAyaka IshibabaYorihiko HigashinoTakuro MatsumuraHiroshi IidaKaya KowaTokushi KogaTomomi HatakedaNobuhiko AtsuchiKana MigitaYukihiko MomiyamaYusuke FukudaMasataka FukueKouji UchidaKatsumi SaitoSakiko IidaSeiji FukamizuJunko HaradaYasuyoshi TakeiSaori TakanoYoshiki HataArisa SatoYumi ShimuraShinko HirataAtsuo NamikiNoriko IshidaIchiro MichishitaTomomi IshimotoKazuo UsudaAkiko OomuraKoichiro KinugawaRumi SasakiTakao MatsubaraHiromi KidaniYoshifumi AwajiYoko KanenoKentaro YamashitaMasami SuzukiHiroshi FujitaAya MashidaTakahisa YamadaShintaro HiraiMinoru IchikawaTakae MuromakiTomohito OhtaniSachiyo YamaguchiYutaka FurukawaMika TakataMasato BadenFutoshi KawasakiHideki TashiroYuko KitaMizuri TakiKuniko SuzukiKenji NakamaChiaki OotaKiyoshi HibiMizuho ShionoSatoaki MatobaNatsuki KimuraAkihiko TakahashiMegumi FujinoTomomi IdeChiharu TanakaOsamu UedaRieko ShimojimaTakehiko KuramochiMichiko AndoHaruhiko OnakaAnri MaedaTetsuya HigamiIkumi NishibeMitsunori AbeMegumi MatsugiJunya AkoKimiko YamamuraTomoya UedaYuki ItokazuKotaro SumiiKano IchiiMasatoshi ShimizuMegumi IrikuraShigeo ShimizuMisa AyabeTaku MatsubaraSatoko KanekoTomomi KoizumiKeiko WatanabeSatoru SakagamiMariko KumakiAtsushi SuzukiTomoe KawanoYusuke KatayamaHiroko NakamuraIsao TaguchiYuko ArakiNobuyoshi HigaYasuka OshiroKumiko YahikozawaShiori AnzaiTatsuya NunohiroDaichi NishiShuichi OsakiYoshiaki TanakaMasayuki KanekoKimiko NoguchiNoriaki WatanabeToru OishiKoichi FuseYukari BabaGa-Eun KimJin-Ok JeongYoung-Eun ChoiHae-Young LeeEunjin HurSeok-Min KangWonmi LeeKye Hun KimJiyeon SongByung-Su YooSeonmi ShinMi Seung ShinHei Won OhEung Ju KimJinju ParkDong-Ju ChoiEun Ji YoonDong Heon YangJihyeong ChoiJung-Hyun ChoiHwayoung JeongJin-Oh ChoiSeo Jin HyunSang-Ho JoLee SujinDong Kyu JinJiwon JeonJoon-Han ShinJi Sung NaDong-Soo KimEunryul OhTiong Kiam OngJuriah SulehanHamat Hamdi Che HassanZati AmniSiti Khairani Zainal AbidinKanaga Lakshimi RavinttiranManuel Odin de los Rios IbarraCarlos Rodolfo Martinez SanchezDiestefano Ronquillo RamirezAbel Salazar GaytanCarmen Gonzalez SandovalMarco Antonio Alcocer GambaWendy Munoz RosalesRamon Miguel Esturau SantaloYazmin Sanchez MendozaGustavo Francisco Mendez MachadoHaydea Hirata AvilaRaul Reyes AraizaJaime Ruiz MoralesJorge Escobedo de la PenaBeatriz Villegas LaraEnrique Lopez RosasMichelle Meza HernandezJaime Chavez MichelElena Ruiz RubioAlberto VarelaCoriet Hobé-RapDirk LokRina DommerholtHenk SwartCatharina Terwisscha van ScheltingaRuud van de WalIlvy van LieshoutPeter van der MeerAnja BranderhorstHenri Albert WernerIvonne van Ruijven-MastenbroekMatthijs F.L. MeijsLinnea OldenhofFrank den HartogMargreeth SingerlingRichard William TroughtonStephanie RoseFraser HamiltonSharon JacquesKatherine FerrierJo-Anne KovacsMayanna LundLynette PearceRobert DoughtyMariska TerbalsNezar AmirCathy HulbertJames PembertonDeborah ScottDennis NilsenJorunn NilsenLars GullestadElisabeth BjorklundHege ClaussenHavard KeilegavlenNina FaalunVidar RuddoxAnnbjoerg PedersenAldo Edwin German Rodriguez EscuderoSonia RomeroBoris OrihuelaMonica del PortalVictor Elias RodriguezNurys Cabanillas GalloFelix Alvaro MedinaJeanneth RodriguezLibia Lu GalarretaJill EspejoMilagros MattaDavid Raymund K. SalvadorWendy Lynn CudiamatEugene ReyesSusan de GuzmanRody SyClaudette SilvaAmelita BrillantesAmy Alon-AlonGabriel Jocson IiiFrances Joyce CortezLouie S TiradorCharity Daine A. GamboaRamoncito S HabaluyasMary Jane IncognitoJoanna SzachniewiczSylwia Nawrocka-MillwardAleksander GochTomasz LugowskiJadwiga NesslerUrszula CzubekEwa Straburzynska MigajAgnieszka PrzepioraZbigniew PijanowskiMonika PijanowskaJaroslaw KasprzakEwa Mirek-BryniarskaWojciech ZarebaWlodzimierz MusialAgnieszka TycinskaPawel MiekusJustyna PrzydatekWaldemar KrysiakEdyta SkorekPrzemyslaw LeszekPaula PolaskaGrzegorz Krzysztof SkoniecznyMonika RoliardMarek WujkowskiMariusz StrupiechowskiMaria DiagoJulio BaezLusdian Casanova-JimenezCarlos R Zayas-TorresAleja DuranPedro J Colon-HernandezMerari CarrasquilloMaria L Rios BonillaMagaly MarcanoPedro Garcia-GordoJessenia Navedo-SantosSvetlana BolduevaNatalia ShvetsNatalia OrlovaMaria KlepikovaAlexander KastanayanLeily BabaevaImad MerayMarina TeterinaYury ShvartsLarisa KonshinaSergey YakushinEvgeniy FilippovSergey SayganovDmitry NikolaevAlexander VishnevskiyVladislas ZykovOleg SolovevDmitry NazarovOlga BolshakovaEkaterina PolunichevaTatiana TreshkurEdvard BerngardtVladimir NosovLubov KorolevaGadel KamalovLiliya UrazaevaOleg IlyukhinEvgeny MorozovKheng Leng David SimYuen Yet LeeShao Guang Sheldon LeeXuan TangDinna Kar Nee SoonBoon Khim LimRaymond Cc WongCher Yi WongSeet Yoong LohGeok ChengGeraldine TanMark Jonathan AbelsonAnnusca KingJunaid BayatKatija BadatNaresh RanjithShavina RamdasTheema NunkooHans Walter ProzeskyChristina NaudeMuhammed Ameen FulatMichelle PretoriusMpiko NtsekheNoloyiso MtanaEric Q KlugVaman NaidooLarisha Pillay-RamayaSharon PhillipsEllen Makoali MakotokoAndonia PageMoelo MalahlehaMosidi PitsoaneGuiomar Mediavilla GarciaJose Ramon Gonzalez JuanateyJose Seijas AmigoManuel Martínez-SellésOlga Sobrino GonzálezEduardo González-FerrerPaz GonzálezNicolas Manito LoriteSonia GuerreroNúria Farré LópezCristina Soler AyatJuan Jose Gomez DoblasMaría RoblesJulio NúñezAnna Mollar FernándezManuel Gómez BuenoAriadna González SegoviaLars H LundAnn Hultman-CadringTymon PolAnnika LangoeOle HansenElse NakeTamas DanyiAnna-Karin KruseChrister MagnussonNinve PaloMichael FuKim FahlenEntela BollanoAnn-Christin WestlundRoger HullinSandrine SalzmannTiziano MoccettiAnna SerraChristian MuellerDayana FloresI-Chen LinJuey-Jen HwangYi-Chun ChenWei-Ting ChangShu-Fen SuTing-Hsing ChaoWen-Hui TsengYen-Wen WuYung-Cheng ChenMing-En LiuVinny ChouYuksel CavusogluMehmet Birhan YilmazVedat SansoyTayfun SahinMurat SezerAhmet CelikMehmet Ali OtoIstemihan TengizOksana ReshotkoOleksandra DonetsYuliia RybachokOleg SychovOlena RomanovaOleksandr KulbachukYuliia KlitsunovaNatalia VelichkoNataliia TomakhIain SquireJudith FisherHugh BethellEmma HowardCraig Scott BarrJulie DeanAndrew ClarkJeanne BulemfuJustin CookeAmanda WhilemanCeri DaviesJane PhebyTheresa McdonaghJonathan BreezeKenneth WongCatherine FlemingJay AminTheresa CervoniShamaila AslamDawn BurnsAlan J BankNicole GernesNoel W BedwellMary CraigBruce J IteldBrandy OcmanRajinder BhallaTeresa HicksA. Alan S.P. ChuSusan NguyenJames FeldmanMadeline PeekFerris GeorgeChristine BakerWayne L GraySherry AdairPreetham JettyAlyssa KeyNavid KazemiSuzette HollisJoshua LarnedMara-Li OrtizJanet L SmithTina AbellLinda CadaretCynthia LarewRobert LongTheresa HickeySharan S MahalSivaradhika YandamuriDavid J WhellanDaniel SchweglerPeter McculloughRebecca BakerJohn McgintyNancy FryJamie M PelzelAshley DouvierJuan VilaroSarah LongRichard PerlmanDonna HoopesRamana PoduguKathleen SmithPeter RahkoKaren J OlsenAshwin RavichandranBonnita ReillyRenee SangrigoliLinda SchwarzTrevor O GreeneCathy JacksonTeleah DavisDennis SpillerSmelda FerrinDilip B ViswanathSue MangaZi Jian XuDeborah Holmes-ReesJon M BittrickEricka CalhounGregory Alan EwaldKaren BultMaryjane FarrAndrea KimLes ForgoshJoyce Riestenberg-SmithNaseem JaffraniRebecca ChildersDouglas Marshall BrinkleyAmanda CarrollDalton S McleanHugh PruittGreg LewisDiane Cocca-SpoffordHarvey A SnyderLouise PantuckEdward J TeufelBrenda GlasgowDaniel J DonovanMaria Magdalena Alvarado-GarciaIra DauberSusan DerbyshireSuhail ZavaroAolani MillerKevin SharkeyAlanza FergusonKirkwood AdamsJana GlotzerJose A PerezJodie AddingtonZulfiquar BhattiCarla BurtonMike B MelucciSusan MeierMichael HuberFujiko AnazawaJenica UpshawKatelyn CarrMark Jeffrey HolmbergLois S RasmussenVanessa J LucarellaKathleen MaloneyKenneth C SabatinoJohn EverettEmily KelleySandhya MurthyAngeline CamilloNancy SweitzerCindy SchragPeter E CarsonJacqueline GannuscioNeil Pendril LewisKrista ChafinAlan Bruce MillerErin RichardsonUsman QayyumPaige BrownDinesh SingalDanielle GiuntaArun KrishnamoorthyReema VallabhAndrew J KellerStephanie BurtonAlexander AdlerDean ThompsonJosef StehlikJennifer HongGary J LuckasenScott KaczkowskiWayne OldMelinda BullivantJohn BoehmerKevin GardnerDinesh K GuptaTammy DaveyHirsch MehtaGina CiezkowskiMichael HongElizabeth HejnaAshrith GuhaMarcos de OliveiraTariq HaddadDeanna OverbeckHamid TaheriAbbey ElieIoana DumitruRicardo GuedesAlain HerouxCarol KartjeMarcel E ZughaibCandice EdilloChad LinkJennifer BoakAndrew DarlingtonKathryn KaszonyiStephen B SloanDeborah WoodMayar JundiAnn OstranderSandeep KhoslaSudha LukkaMarcus L WilliamsKimberly MichelAndre ArtisKimberly ArmstrongNicholas KondoGretchen KostedtIsrael GaltesYasnhai DiazLuis MartinezBeatriz PenafielJose F CardonaAbril JuarezShuaib AbdullahAmy AtwellAlbert J SharfLeonardo CortesRavi BhagwatDonna WinterrowdElie Michael DonathMaria YcazaAlonzo JonesEve GillespiePat Keane-RichmondRichard BeckerRachel MardisPeter S FailVicky ParfaitSiby AyallooreTessie RideauxWade MayJulie ZanniniAtul R ChughStephanie AlfordMohsin AlhaddadLani HolmanRussell J StraderAlicia GneitingTerry WellsJessica SmithVernon YoungCynthia BuchananIsh K SinglaJustin RothHenry OoiLaura DiedrichHarry T ColferDenise AntonishenAngela Romero ZaranteYenisca ZambranoMiguel Angel HominalMartin SuarezEzequiel Hector VotteroMarcia LopezOscar MontañaGloria CendaliMarisa VicoErica GiozziDiego AizenbergSantiago CoussioDiego ArakakiMiriam GelerszteinScott MckenzieKathryn StibiljDavid Martin ColquhounGemma MacdonaldJohn AthertonLydia LilwallCarmine de PasqualeSimeoni ThomasAlicia ChanDenise HealyBrendan McquillanNatalya BeerDirk von LewinskiViktoria RauschAndreas SchoberMaria-Christine LeitgebChristopher AdlbrechtCordula KoehlerJohann AuerManuela RossmaierMoritz MirnaKristen KoppJose SaraivaCarla Cristina VicentePedro SchwartzmannGabriela IlanaAguinaldo FreitasSandra CostaLidia MouraFernanda de LizRicardo Mourilhe RochaRoberta CoelhoFabiana Marcondes-BragaTalita AntunesMarcus SimoesVeronica SilvaJoao SouzaGrazielle FreireFábio SilveiraTamyres GalvãoEuler ManentiCarollainy SilvaRonald Leonard BourgeoisKaren BoydThao Thanh HuynhCaroline BoudreaultMichael HartleibRebecca OtisJames Y ChaJudy OtisMichael HeffernanMarie BirchA. Shekhar PandeySamantha ArmstrongAshok MukherjeeLubna ZakriaMarie-Claude ParentHelene BrownDoug HayamiDeborah KellerStephen Allan SchafferWendy JanzYves PesantYanick Sardin-LaframboiseQuentin KushnerikAnnie RoyGilbert GosselinNathalie LeblancYaariv KhaykinDebbie NemteanGordon MoeCarlos FernandoYing SiaAmelie BujoldJonathan HowlettAnusha SasikumarElizabeth SwiggumNoreen LounsburySerge LepageCarl FortierSubodh VermaDebbie ChenFernando LanasPamela FigueroaGabriel MaluendaMaria VergaraJuan PrietoViviana NoriegaLuis MoralesJessica ZapataPatricio YovaninizMarcela GrandonFranco AppianiTatiana del RioSergio MelladoClaudia AlvarezGerman CruzSebastian MinoJuan Carlos Palma CarvajalVeronica OlguinPaz BourkeMaribel Toledo GrellHugo MarinSebastian RiosManuel NovajasMacarena Carcamo MedinaJingmin ZhouMingfeng LuJiyan ChenYihan JiangJunkui WangYuhong KangLuping JiangYuxin ZhongWei JinShanshan JinJianzeng DongJiajia WangJianqiang PengXiaomei PengAijie HouRuili DuanWeihong JiangXiaowei ZhouXiang GuWenjuan DaiYibin MeiMiaoxia LiuJing YuJinxia ChenZuyi YuanAidong ShenYutao WangRuiping ZhaoPeiyan RenZhuhua YaoXiying ZhangJingfeng WangHuijun OuyangMaohua ChenYu LuPeizhi MiaoZhenfei ChenZhouqing HuangXiaoli TengJiahong WangXuyao YanBiao XuYue GaoPing QiaoMizozhu HanMingya LiuShaorong WuRuihao LiQian LiangZhengzheng NiQilin MaTing LiHongliang CongChuangting ZhuGuangping LiLin LiuWeimin LiJunsheng JingQing ZhangJia TangCuimei ZhaoLiao TingXiaosheng HuYao FangYuehui YinXuejun LiuJun JiangMengqing ZhangYuanyuan LuoSiqi WangPing ZhangPeng ZhangYanqing WuWenting WeiXiaohua PangYanqiong XiaLihong WangChenyu LvZhihua FangQiaochu DuPing YangXuejiao LiuWei YuanMin WangKai HuangDanli XiangLikun MaJinxiu LiuClaudia Garcés RestrepoJose AcciniYineth Conrado OrtegaRodrigo BoteroAleydy CaceresAlberto CadenaJessica MartinezMiguel Moncada CorredorLeisa FlorezCamilo AranaLizzette Diaz VillegasDora Molina de SalazarMaria ValenciaJuan CarvajalPaola DelgadoLuis EcheverriaKaren Bueno DiazJuan Gomez-MesaLaura TrujilloEduardo EcheverryAdriana EscruceriaMelissa Reyes DiaAdriana Cervantes HurtadoLadislav BusakBlanka PokornaVojtěch MelenovskýAnna KuprovaMartin HajslJana BrindovaRoman MiklikVeronika MusilovaLibor NechvatalMartin RadvanRenata MachovaJan BelohlavekPetra ZavadilovaZdenek MonhartLenka BouzkovaTomas DrasnarMatej FaldNora BolvanskaHelena PackovaJan KrejciJana RocheJens HoveLotte RingMorten LindhardtTherese Bang-HansenJens Due LomholdtKari NiemannKristian MadsenJoan HummelshoejKenneth EgstrupLinda HindsgaulMorten SchouJette MadsenSøren NielsenEmilie JakobsenHenrik WiggersMarianne LethLars KoberElsebet EriksenNiels Eske BruunWinnie KraghJens Bronnum-SchouPia HadsundHenrik VadmannAnnette NielsenMichel GalinierNathalie RosolinJean-Michel TartierePauline ArmangauEmile FerrariNassima BelkacemCadi AludaatLine Balaya-GourayaEmmanuelle BerthelotAgnes PezziNicolas GirerdEmilie TachotTeodora DutoiuAnne-Sophie DerienEmmanuel BoiffardPhilippe PrunierFrancois PicardManel 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KimByung-Su YooBoram ParkSang-Ho JoGaeul ChaeWook-Jin ChungMiju YouHyun-Jai ChoDiego Rodriguez PenasKye Hun KimCatalina Carrasco OssorioAntonio Reyes DominguezRuben Martinez JaenJulio Nunez VillotaJudith ViaplanaIgnacio FerreiraIsabel Sicilia BravoJosep Comin-ColetPaz Gonzalez PortillaJosebe Goirigolzarri ArtazaCristina SolerJesus Alvarez GarciaPaloma GastelurrutiaGuiomar Mediavilla GarciaAntoni Bayes GenisZulaica Grille CancelaEsteban Lopez de Sa AresesKristina FromMaria Generosa Crespo LeiroPernilla HaglundNiklas BerghMalin BrobergBarna Szabo-SoderbergKristina ErikssonCarl-Johan LindholmCarina AnderssonNiclas SvedbergIsabel TronstadIngemar LonnbergHåkan SödergrenEmil NajjarBirgitta RangmanMarcus LindChiao-Wen ChangAke OlssonVinny ChouChern-En ChiangHuey-Pyng SuMing-En LiuPing-Ping ChouI-Chang HsiehHui-Ling HuangJin-Long HuangHsiao-Ting LeeTsung-Hsien LinAkin AydinChien-Hsun HsiaBurcu KaygusuzYuksel CavusogluSelin YildirimBahar TakÖzge DurhanSanem NalbantgilEmel SahinAhmet CelikEbru SahinHakan AltayFatma Nur ErtuncErsel OnratGizem Celik EminogluCihan AltinEsmanur MizrakTayfun SahinBulut AkbulutErgun Baris KayaEzgi AslanHasan BarmanBerna AkinVineet VenugopalIulia VolchykThomas Duythuc ToTaras ChendeyOleksandr KulbachukMishka PavelkoRoman StetsOlena BeregovaMykola RishkoOksana PysankoAndriy YagenskyYaroslav LutaiLeonid RudenkoGanna RudyaDmytro ReshotkoAndriy YurkivOleksandr ParkhomenkoOksana GliebovaLarysa MishchenkoDiana SchyhypakOlena LevchenkoHalyna HavryliukOleksandr ProkhorovOksana BilonkoOleksandra DonetsAlla DzybaHalyna MyshanychOlha RadchenkoSergii ShevchukAndrii DanyliukIvan VyshnyvetskyyTetiana DankoVira TseluykoTaras PetrovskyyAndrii KlantsaVolodymyra SovtusAnna KulykTetiana ShandraRoman PetrovskyyElena RomanovaIgor VakaliukDenys BabichevSvitlana ZhurbaGanna KrotenkoOleg SychovNataliia KumpanIurii RudykSvitlana TrubinaOzlem YildirimturkSandra ElphickAhmet GencAlexandra FlorouAhmet FuatRita AdregoCraig Scott BarrSinead LyonsTheresa McdonaghSarah BroadheadLisa AndersonJoanna BrownJustin CookeMichelle KinninChristopher CassidyFrancis GaleraAndrew MoriartyAbeesh PanickerIfy MordiLisa MellishManish SaxenaSusan CrawfordPrithwish BanerjeeRosemary HarperMatthew DewhurstDeborah JonesMadhusudhan VarmaBen JonesBassem IbrahimRebecca CuttsAaron WongAngela DoughtyRumi JaumdallySusan ReganPatrick MooreLani HolmanDavid WilsonCynthia LarewPatrick DonnellyHaydee GutierrezMohsin AlhaddadPhillippa Mccartney MoralesLinda CadaretJorge AllinaMehrdad ArianiSajad HamalRasha YoussefMaite RamirezDavid BernardMadeline PeekMatthew BudoffKelli CloppJose F CardonaJaime WyattJames FeldmanStephanie LambertFerris GeorgeBeatriz PenafielEve GillespieMarie RenoObinna IsiguzoLinda SchwarzLuis MartinezRose HroncichUsman QayyumDonna WinterrowdRenee SangrigoliSabrina ForbusMarcus L WilliamsKevin ThorntonRavi BhagwatCrystal DuboisBrian FoleyHeather MaschenikAshish GangasaniMoravia VasalloNaseem JaffraniAnne DirksFelix SogadeLauren StamschrorJavier VasalloLeigha HughesGregory Alan EwaldMohamed KhalilMajdi AshchiNancy FrySandeep KhoslaHeather BlubaughHahn BuiSmelda FerrinJohn McgintyRafael MuroJesse DoranAbeer Abu-SaifDennis SpillerJennifer BajornasHamid TaheriMarisol RamosImad HaririAlicia PhillipsAtaul QureshiJill SchulteNarendra SinghVicky ParfaitAndrea PhillipsMalcolm LustJuliane ViereckeMargie MckercherPeter S FailJacqueline KillianRobert LongVictoria SmithRamon LloretRema IskandaraniNabil DibBreanna CulverSiby AyallooreAli MuhammadKatherine MichelisStephanie AlfordFahed BitarAmy KingLokesh ChandraRichard JacksonVijay RaoHailey JenkinsDavid HotchkissYulia AbidovRichard JacksonAriel QuebedeauxMatthew JanikSharyce Hayes-JonesMarcel E ZughaibTeresa OsmulskiWade MayNatalie FialloDilip B ViswanathEmily GilderAlexander AdlerAmanda ReynoldsJoshua LarnedAshley WilliamsJoseph SurberApril HowarterMark NapoliRobert EdmondWayne OldAlison SolomonChristopher SparrowMihret AssefaDivya GuptaNicole ScottGlenn HamroffSirisha TirumanisettiChrisette DharmaShelli RobertsWilliam HerzogLynett ZacharyIyad IssehLoren MooreChristopher DanielsKimberly ArmstrongLars RunquistSvetlana StrugatskyGhiyath TabbalNehal VekariyaAndre ArtisRamona StevensFreny ModyIbraheem AlajlouniPankaj AroraPeter OsmondMahfouz El ShahawyYasmire EvansGhiath MikdadiNadine KallasJoseph IzzoIluyomade AdeusiAnu Lala-TrindadeLisa EnglishBrian BostickAnastasiia PiskunAlexandra CornellConstance HamlinKatie LamontMartina ZilliChristi KentJaco de KlerkChristina SalernoLydia ChristopherScott MckenzieFabiana MarcondesShelley ZierothAnique DucharmeJunbo GeJuan Esteban GómezStefan StoerkGerasimos FilippatosPablo MontenegroAlex LeeKen McdonaldMarco MetraImran AbidinFelix Alvaro MedinaDavid SimKaren SliwaMarisa LeiroYüksel CavusogluPalak ShahBarry GreenbergTom D CookAldo MaggioniKarl SwedbergJane E WilcoxMaria Rosa CostanzoHaley HedlinW. Schuyler JonesKaren P AlexanderSana M Al-KhatibJorge GutierrezRobert W HarrisonMark KittipibulBradley KollsDavid KongJoseph LermanRobert MatthewsRobert McgarrahRajendra MehtaThomas J PovsicJennifer RymerCina Sasannejad
• Organismes : Défaillance Cardiovasculaire Aiguë et Chronique Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] French-Clinical Research Infrastructure Network - F-CRIN [Paris] Inova Heart and Vascular Institute [Falls Church, VA, USA] Baylor Scott and White Research Institute [Dallas, TX, USA] University of Southern Mississippi Merck Sharp and Dohme Université de Caroline du Nord à Chapel Hill = University of North Carolina [Chapel Hill] Merck Sharp and Dohme University of Colorado [Colorado Springs] Bayer, Research & Development, Pharmaceuticals Bayer HealthCare Pharmaceuticals, Inc. [Basel, Switzerland] Pharmaceutical Sciences, Merck & Co. Inc. University of Alberta Duke Clinical Research Institute National Heart Centre Singapore Duke-National University of Singapore Graduate Medical School Stanford School of Medicine [Stanford] Vanderbilt University Medical Center [Nashville] Duke University Medical Center Wrocław Medical University Mayo Clinic [Rochester] Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele [Roma] San Raffaele Open University of Rome Universidad Pontificia Bolivariana Universidad de Antioquia = University of Antioquia [Medellín, Colombia] Hospital Papa Giovanni XXIII Università degli Studi di Milano-Bicocca = University of Milano-Bicocca Technische Universität Munchen - Technical University Munich - Université Technique de Munich Bayer AG [Germany] Tufts Medical Center [Boston] Merck Sharp and Dohme Bayer U.S., LLC, Whippany, NJ. University Medical Center Groningen [Groningen] Pharmaceutical Sciences, Merck & Co. Inc. BAIF Institute for Sustainable Livelihoods and Development, Gujarat, India. Merck Sharp and Dohme University of Alberta Charité - UniversitätsMedizin = Berlin University Medicine German Center for Cardiovascular Research German Heart Center Berlin Merck Research Laboratories Bayer AG [Germany] Institut photonique d'analyse non-destructive européen des matériaux anciens Excelia Group | La Rochelle Business School Transitions Energétiques et Environnementales Centre National de la Recherche Scientifique
• Publié dans The Lancet le 02/11/2020

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Résumé :

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Fichiers liés : 1-s2.0-S0140673625016824-main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Jason RosadoAbebe FolaSandrine CojeanVéronique SarrasinRomain CoppéeJustine BaillyRizwana ZaffaroulahAzza BouzayeneLiliane CicéronLudivine HouzéRebecca CrudaleLise MussetMarc ThellierBruno PradinesJérôme ClainJeffrey BaileySandrine HouzéAhmed AboubacarPatrice AgnameyAbou-Bacar AhmedDaniel AjzenbergAdela AngoulvantFrédéric ArieyBenjamin AubryFirouze BanisadrSorya BelazGhania BelkadiGhania Belkacem BelkadiAnne Pauline BellangerDieudonné BembaFarida BenaoudiaMartine BlochFrancoise BotterelVincent BoudenMarie-Elisabeth BougnouxCaren BrumpSophie BrunJulie BrunetBernadette BuretPauline Caraux-PazNourrisson CelineSylvain ClauserElody CollinNaima DahaneCéline DamianiEric DannaouiCéline DardMarie-Laure DardeAnne DebourgogneThierry DelacourJean-Marie DelarbreAnne DelavalVeronique DelceyAnne-Sophie DeleplancqueGuillaume DesoubeauxNathalie DesuremainGisele DewulfRémy DurandMarie-Fleur DurieuxEmmanuel DutoitOdile EloyJean-François FaucherLoïc FavennecAlbert FayeOdile FenneteauCécile FickoEmilie FrealleGilles GargalaCéline GarnaudLudovic De GentileNadine GodineauJudith GorlickiYohann Le GovicAlain GravetNadia GuennouniSamia HamaneThomas HanslikAntoine HugueninJean-Pierre HurstFakhri JeddiLeroy JordanLuce LandraudHélène LapillonneSébastien LarréchéRose-Anne LavergneJean Philippe LemoineCécile LeprinceElodie LestevenAngèle LiCaroline LohmannBasmaciyan LouiseMarie-Claire MachouartCéline MalassigneAnthony MarteauDanièle MaubonEdith MazarsBruno MégarbaneAna Mendes-MoreiraSylvain MermondGwénaël Le MoalAlicia MorenoPierre MornandJean-Benjamin MuratRené NabiasJerome NaudinGilles NevezCéline NourrissonMouri OussamaNathalie ParezOlivier PateyPierre PatozGauthier Pean-De-PonfillyJean Yves PeltierPascale PennAlice PerignonEstelle CateauAlexander PfaffSorya BelazMarc PihetJean-Etienne PiloIsabelle PoilanePhilippe PoirierDidier PoissonDenis PonsLauren PullDorothée QuinioDidier RaffenotMatthieu RevestGladys RobertOlivier RogeauxGabrielle RoosenMilène SassoFrançoise SchmittBoualem SendidYaye SenghorMuriel SilvaJean-Yves SiriezEmilie SitterléFrédéric SorgeMaurellet Evrard SylvieIlhame TantaouiDominique ToubasAli Cherif TouilCéline TournusHélène Yera
• Organismes : Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique Brown University Biologie moléculaire et immunologie parasitaires et fongiques Université Paris-Saclay Centre National de Référence Paludisme [AP-HP Hôpital Bichat-Claude Bernard] Centre National de Référence Paludisme [AP-HP Hôpital Bichat-Claude Bernard] Risques Infectieux Tropicaux et Microorganismes Emergents Institut Hospitalier Universitaire Méditerranée Infection Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest] Microorganismes, Hôtes, Environnements [Équipe du laboratoire EBI Poitiers] Laboratoire de Parasitologie et Mycologie Médicales [CHU de Poitiers] SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie-Mycologie, CHU d'Angers, Angers, SFR UA 4208 Interactions Cellulaires et Applications Thérapeutiques Infections Respiratoires Fongiques Laboratoire de Parasitologie et Mycologiede [CHRU Brest]
• Publié dans EBioMedicine le 28/10/2020

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Résumé : Background: Given the altered responses to both artemisinins and lumefantrine in Eastern Africa, monitoring antimalarial drug resistance in all African countries is paramount. Methods: We measured the susceptibility to six antimalarials using ex vivo growth inhibition assays (IC50) for a total of 805 Plasmodium falciparum isolates obtained from travellers returning to France (2016-2023), mainly from West and Central Africa. Isolates were sequenced using molecular inversion probes (MIPs) targeting forty-three genes across the parasite genome, of which nineteen are drug resistance genes. Findings: Ex vivo susceptibility of all assessed antimalarial compounds was consistent with their potent activity. The median IC50 values for the six drugs were 1.1 nM [IQR: 0.8-1.7] for DHA, 16.7 nM [9.9-27.4] for LMF, 29.5 nM [19.1-45.5] for MFQ, 23.4 nM [17.1-39.0] for MDAQ, 26.7 nM [18.0-41.2] for CQ, and 18.5 nM [15.1-24.3] for PPQ. Only four isolates carried a validated pfkelch13 mutation. Multiple mutations in pfcrt and one in pfmdr1 (Asn86Tyr) were significantly associated with altered susceptibility to multiple drugs, and their frequencies decreased over time. Pfcrt and pfmdr1 mutations altered susceptibility to lumefantrine and mefloquine in an additive manner, with the wild-type haplotype (pfcrt K76-pfmdr1 N86) exhibiting the lowest susceptibility. Interpretation: Our study on P. falciparum isolates from West and Central Africa indicates a low frequency of molecular markers associated with artemisinin resistance and a modest but significant decrease (1.6-2.3X) in the frequency of multidrug resistance markers. These genotypic changes likely mark parasite adaptation to sustained drug pressure and call for intensifying the monitoring of antimalarial drug resistance in Africa.

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Fichiers liés : main.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Etienne BrainOlivier MirEmmanuelle BourboulouxOlivier RigalJean-Marc FerreroSylvie KirscherDjelila AllouacheVéronique d'HondtAude-Marie SavoyeXavier DurandoFrançois DuhouxLaurence Venat-BouvetEmmanuel BlotEmmanuel BlotJean-Luc CanonFlorence Rollot-TradHervé BonnefoiTelma RoqueJérôme LemonnierAurélien LatoucheJulie HenriquesMagali Lacroix-TrikiDewi VernereyVéronique D’hondtSophie Abadie-LacourtoisiePaul CottuGilles RomieuEmmanuelle MalaurieSylvain LadoireCatherine TerretVéronique ServentLoic MoureyClaudia LefeuvreElisabeth CarolaLionel UwerVéronique GirrePierre GuilletMarc DebledLucie Monceau-BarouxJean-Claude DarmonFrancesco del PianoLaetitia JolyHugues BourgeoisValérie DelecroixFrédérique RousseauJean-Philippe JacquinThierry PetitLaetitia StefaniClaire FalandryOana CojocarasuAnne Mercier-BlasCarol AlliotHeba DawoodEric RaymondBénédicte PetitChristophe TournigandDenis HeitzJean-François BerdahMarc BaronPeter VuylstekeMarie-Pascale GraasPhilippe HouyauPhilippe GlorieuxAnnelore BarbeauxVictor SimmetJérôme DaubaFrederic ForgetJean-Emmanuel KurtzLionel DuckGuillermo Reyes OrtegaSophie BarthierLionel d'HondtEtienne SucChantal Bernard-MartyLaurent CanyNadia RabanGaëtan Des GuetzJorge AyllonVincent Richard
• Organismes : Imagerie Moléculaire et Stratégies Théranostiques Centre Jean Perrin [Clermont-Ferrand]
• Publié dans The Lancet le 02/11/2020

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Résumé : For women aged 70 years or older with oestrogen receptor-positive HER2-negative invasive breast cancer, hormonotherapy is a standard adjuvant treatment, while the role of chemotherapy is debated. We aimed to assess the effect of adjuvant chemotherapy on overall survival in these older patients with high-risk tumours according to a prognostic genomic signature.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Kaori SaitohMohamed LajnefWahid BoukouaciMyrtille AndreChristelle AndrieuBruno AouizerateCaroline BarauJihène BouassidaDelphine CapdevielleIsabelle ChereauJulie Clauss-KobayashiNathalie CoulonJean-Michel DoreyCaroline DubertretEric FakraGuillaume FondTudi GozéP. Le CorvoisierSylvain LeignierPierre-Michel LlorcaJasmina MalletDavid MisdrahiNicolas OriolBaptiste PignonRomain ReyPaul RouxFranck SchürhoffBenoit SchorrMathieu UrbachEtienne VeryChing-Lien WuMarion LeboyerOphélia GodinRyad Tamouza
• Organismes : IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Pôle de Psychiatrie [Hôpital Henri Mondor] Fondation FondaMental [Créteil] Département de Psychiatrie adulte [Hôpital de la Colombière - CHU Montpellier] Fondation FondaMental [Créteil] Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] Centre hospitalier Charles Perrens [Bordeaux] Nutrition et Neurobiologie intégrée Fondation FondaMental [Créteil] Plateforme de Ressources Biologiques [Henri Mondor AP-HP, Créteil] Fondation FondaMental [Créteil] IMRB - "Neuropsychiatrie translationnelle" [Créteil] Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie = Addiction And Psychiatry Transformation with Precision Medicine [Créteil, France] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Institut Pascal Fondation FondaMental [Créteil] Centre Hospitalier Universitaire [Strasbourg] Sociétés, acteurs, gouvernement en Europe Institut d'Électronique et des Technologies du numéRique Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Hôpital Louis Mourier - AP-HP [Colombes] Institut de psychiatrie et neurosciences de Paris Fondation FondaMental [Créteil] Université Sorbonne Paris Cité Psychiatric Disorders, Neuroscience Research and Clinical Research Université Jean Monnet - Saint-Étienne Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre d'études et de recherche sur les services de santé et la qualité de vie Equipe de Recherche sur les Rationalités Philosophiques et les Savoirs Service Psychiatrie, Psychothérapies et Art-thérapie [CHU Toulouse] Fondation FondaMental [Créteil] Institut National de la Santé et de la Recherche Médicale Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Institut Pascal CHU Clermont-Ferrand Fondation FondaMental [Créteil] Association française de psychiatrie biologique et neuropsychopharmacologie = French Society for Biological Psychiatry and Neuropsychopharmacology Fondation FondaMental [Créteil] Institut de psychiatrie et neurosciences de Paris Hôpital Louis Mourier - AP-HP [Colombes] Université de Bordeaux Centre National de la Recherche Scientifique Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre de recherche en épidémiologie et santé des populations Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Centre de recherche en épidémiologie et santé des populations Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil]
• Publié dans Psychiatry Research le 25/10/2020

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Résumé : Schizophrenia (SZ) is characterized by a variable clinical expression and course peppered/hampered by severe complications. In particular, resistance to treatment (overall-TRS, treatment resistant SZ including UTRS, ultra-TRS) and metabolic syndrome (MetS) are highly prevalent, and both demonstrated to be underpinned, at least partly, by pro-inflammatory processes. Given that such processes also underlie SZ per se , we hypothesized that potential inter-twinning between SZ-and MetS-related inflammatory processes may exert a combined effect on the risk of having overall-TRS/UTRS. A total of 419 outpatients with SZ underwent clinical assessments and blood sample collection. Using the values of circulating levels of eleven cytokines, we built a ratio between pro-and anti-inflammatory components respectively corresponding to the immunoinflammatory response system (IRS) and the compensatory immunoregulatory reflex system (CIRS) which overall reflect the underlying in-flammatory status. Such ratios allowed to categorize the patients according to Inflammation and MetS on four categories as follow: symbolscript symbolscript symbolscript and Inflam-mation(-)MetS(-). Multivariate logistic regression analysis showed that the combination of inflammation and MetS modulate the risk of having the overall-TRS symbolscript symbolscript 95 %CI [1.04-5.00], p symbolscript 0.039 and symbolscript symbolscript 95 % CI [1.76-11.97], p symbolscript 0.002 overall in comparison to Inflammation(-)MetS(-)]. Moreover, we observed that individuals with UTRS are those associated with both inflammation and/or MetS. Our results demonstrated the potential combined effect of MetS and inflammation towards resistance to treatment. Given that overall-TRS/UTRS are unpredictable while both inflammation and MetS can be early detected and managed, our findings shed new light on the possibility to better prevent treatment resistance in SZ.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/08/2025
• Auteurs : Camille RobinFabien RollotMathilde LefortRomain CaseySandra VukusicGuillaume MatheyJonathan CironJérôme de SèzeBruno StankoffElisabeth MaillartAurélie RuetPierre M. LabaugeArnaud KwiatkowskiHélène ZéphirCaroline PapeixGilles-Louis DeferChristine Lebrun-FrénayThibault MoreauDavid-Axel LaplaudEric BergerPierre ClavelouEric ThouvenotOlivier HeinzlefJean PelletierOlivier CasezBertrand BourreAbir WahabLaurent MagySolène MoulinJean-Philippe CamdessanchéInès DoghriMariana SarovKarolina HankiewiczCorinne PottierAmélie dos SantosÉric ManchonMaya TchikviladzeChantal NifleAnne KerbratGilles EdanEmmanuelle Le PageLaure Michel
• Organismes : Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Université Claude Bernard Lyon 1 Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Université Claude Bernard Lyon 1 Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS Université Claude Bernard Lyon 1 Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Observatoire Français de la Sclérose En Plaques [Lyon] Fondation Eugène Devic EDMUS INterdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes Service de neurologie [CHRU Nancy] Institut Toulousain des Maladies Infectieuses et Inflammatoires Centre Ressources et Compétences sclérose en plaques (CRC-SEP) [CHU Toulouse] Centre Hospitalier Universitaire [Strasbourg] CIC Strasbourg Institut du Cerveau = Paris Brain Institute Centre de Ressources et de Compétences Sclérose en Plaques (CRC-SEP) Paris CHU Pitié-Salpêtrière [AP-HP] Centre de Ressources et de Compétences Sclérose en Plaques (CRC-SEP) Paris Centre Hospitalier Universitaire de Bordeaux Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale Centre Hospitalier Régional Universitaire [Montpellier] Université de Montpellier Université catholique de Lille - Faculté de théologie Groupement des Hôpitaux de l'Institut Catholique de Lille Centre Hospitalier Régional Universitaire [CHU Lille] Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Lille] Hôpital Fondation Adolphe de Rothschild = Adolphe de Rothschild Foundation Hospital Université Paris Cité CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Centre Hospitalier Universitaire de Nice UR2CA - URRIS - Unité de Recherche sur le syndrome Radiologique ISolé et maladies apparentées Service de Neurologie générale, vasculaire et dégénérative (CHU de Dijon) Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology Centre d'investigation clinique (CIC) de Nantes -CIC Plurithématique Centre Hospitalier Régional Universitaire de Besançon CHU Louise Michel [Clermont-Ferrand] Neuro-Dol Centre de Ressources et de Compétences sur la Sclérose en Plaques (CRC-SEP) [Clermont-Ferrand] Service de Neurologie [CHU Nimes] Institut de Génomique Fonctionnelle Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS [Poissy] Centre de Ressources et de Compétences Sclérose en Plaques (CRC-SEP) Paris Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Pôle Psychiatrie et Neurologie [Grenoble] Université Grenoble Alpes CHU Rouen Hôpital Henri Mondor CHU Limoges Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] Hôpital Bretonneau Service de neurologie [Le Kremlin Bicêtre] Centre Hospitalier Universitaire de La Réunion hôpital NOVO Centre hospitalier universitaire de Poitiers = Poitiers University Hospital CIC Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Centre Hospitalier de Gonesse Hôpital Foch [Suresnes] Centre Hospitalier de Versailles André Mignot Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Centre d'Investigation Clinique [Rennes] Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer Centre d'Investigation Clinique [Rennes]
• Publié dans Neurology le 01/11/2020

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Résumé : Background and objectives: The therapeutic strategy in patients with late-onset MS (LOMS) remains poorly defined. In this study, we aimed to evaluate both clinical and MRI outcomes between 2 cohorts of patients with relapsing-remitting LOMS treated or not yet treated. Methods: Patients with relapsing-remitting MS were included for the analysis if disease onset occurred after 55 years and if they had at least one follow-up visit. The primary outcome was time to first relapse between 2 matched groups of patients with LOMS (treated and not yet treated). Secondary outcomes were as follows: (1) time to first confirmed disability progression (CDP), (2) time to first progression independent of relapse activity (PIRA) event, (3) time to secondary progression (SPMS), (4) time to first MRI activity, and (5) serious infection incidence rates (IIRs). For the comparative analyses, we adopted a time-dependent propensity score matching approach. Results: A total of 881 patients fulfilled the inclusion criteria. The mean (SD) age at onset was 59.9 (4.43) years. After applying propensity score matching, 436 patients were matched. The mean (SD) follow-up duration was 5.2 (4.27) years in the treated group and 5.0 (3.86) years in the not-yet-treated group. Mean (SD) time to first relapse was significantly longer in the treated group compared with the not-yet-treated group (7.0 years [0.33] vs 5.4 years [0.33]; p = 0.001). Mean (SD) time to first MRI activity was significantly longer in the treated group (5.9 years [0.33] vs 5.0 years [0.33]; p = 0.049). However, the mean time to CDP, PIRA, or SPMS was not different between the 2 groups (difference = 0.32 years; p = 0.585 for CDP; difference = 0.40 years; p = 0.442 for PIRA; difference = -0.02 years; p = 0.952 for SPMS). No increase in serious IIRs was observed with an incidence rate ratio of 0.38 (95% CI 0.07-2.10, p = 0.265) in the never-treated group compared with the treated one. Discussion: This study demonstrates a beneficial effect of disease-modifying therapy (DMT) on disease activity in patients with LOMS but without significant impact on disability progression. Main limitations are linked to the challenge of data collection and to the baseline imbalances between the 2 groups. Classification of evidence: This study provides Class III evidence that in patients with LOMS, treatment with DMTs is associated with a longer time to first relapse compared with those not treated with DMTs.

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