Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Mathilde BanjanChristian CrouzetPierre SabatierHervé JomardManon BajardFrançois DemoryAnne-Lise DevelleJean-Philippe JennyErwan MessagerBernard FangetEmmanuel MaletNathaniel FindlingPhilippe AlainJulien DidierVincent BichetSylvain Clapot
• Organismes : Université Gustave Eiffel Laboratoire de Recherche commun IRSN-CNRS-Lille1 "Cinétique Chimique, Combustion, Réactivité" Université Gustave Eiffel Environnements, Dynamiques et Territoires de Montagne Bureau d'évaluation des risques sismiques pour la sûreté des installations University of Oslo Aix Marseille Université Environnements, Dynamiques et Territoires de Montagne Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Université Gustave Eiffel Université Savoie Mont Blanc iXBlue [Bonneuil - FR] Laboratoire Chrono-environnement (UMR 6249) Laboratoire Chrono-environnement (UMR 6249)
• Publié dans Sedimentology le 29/10/2020

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Résumé : In the French north-western Alps, several lakes of glacial origin, such as Aiguebelette and La Thuile, present some mass-transport deposits within their sedimentary sequences. These event layers can result from lake sediment destabilization eventually triggered by earthquakes. On Lake Aiguebelette, based on sedimentological, geochemical and magnetic analyses, and high-resolution seismic and bathymetric surveys a ca 1 m thick event layer was identified in the deepest lake basin and a synchronous ca 2 cm thick deposit in the shallow basin. Age-depth models based on radiocarbon ages reveal that both mass-transport deposits in Lake Aiguebelette occurred around the Younger Dryas - Early Holocene climatic transition (i.e. 11 700 cal bp) time range. In Lake La Thuile, located 30 km away, unique mass-transport deposits (translational slide type) were recorded at the same time range in sedimentary records. Additionally, high-resolution seismic profiles previously acquired in Lake Annecy and Lake Bourget support the hypothesis of significant mass-transport deposits occurring at the Younger Dryas - Early Holocene time range. These outcomes on four north-western peri-Alpine and Alpine lakes highlight the regional occurrence of mass-transport deposits in the Younger Dryas - Early Holocene time range. Seismic and rockfall events are discussed as potential sources of these significant and similarly aged mass-transport deposits. Based on this study and a literature review, the authors suggest that mechanisms induced by rapid climate change and glacial retreat, such as crustal rebound and erosional unloading, could favour the triggering of earthquakes and rockfall events. In the case of mass-transport deposits archived in north-western Alpine lakes during this time period, this study favours the hypothesis of increased seismicity as the primary source driving process involved.

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Fichiers liés : 2023_Banjan_Sedimentology.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Jean-Philippe SalaünAudrey ChagnotArnaud CachiaNicolas PoirelValérie Datin-DorrièreCléo DujarrierEloïse LemarchandMarine RollandLisa DelalandePierre GressensBernard GuilloisOlivier HoudéDamien LevardClément GakubaMarine MoyonMikael NaveauFrançois OrliacGilles OrliaguetJean-Luc HanouzVéronique AginGrégoire BorstDenis Vivien
• Organismes : Hôpital Côte de Nacre [CHU Caen] Physiopathologie et imagerie des troubles neurologiques Université de Caen Normandie Laboratoire de psychologie du développement et de l'éducation de l'enfant Institut de psychiatrie et neurosciences de Paris Laboratoire de psychologie du développement et de l'éducation de l'enfant CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Physiopathologie et imagerie des troubles neurologiques University of Manchester [Manchester] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Laboratoire de psychologie du développement et de l'éducation de l'enfant Maladies neurodéveloppementales et neurovasculaires Laboratoire de psychologie de Caen Normandie CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie Laboratoire de psychologie du développement et de l'éducation de l'enfant Physiopathologie et imagerie des troubles neurologiques Service de Soins Intensifs [CHU Caen] Laboratoire de psychologie du développement et de l'éducation de l'enfant Unité Support CYCERON Laboratoire de psychologie du développement et de l'éducation de l'enfant GIP Cyceron Service d'anesthésie-réanimation pédiatrique et obstétricale [Hôpital Necker – Enfants malades] Université de Caen Normandie Physiopathologie et imagerie des troubles neurologiques Établissement Français du Sang Normandie [Rouen] GIP Cyceron Institut Blood and Brain @ Caen-Normandie [Caen] Université de Caen Normandie Laboratoire de psychologie du développement et de l'éducation de l'enfant CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie
• Publié dans Anesthesia & Analgesia le 26/10/2020

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Résumé : Background: One in 7 children will need general anesthesia (GA) before the age of 3. Brain toxicity of anesthetics is controversial. Our objective was to clarify whether exposure of GA to the developing brain could lead to lasting behavioral and structural brain changes. Methods: A first study was performed in mice. The behaviors (fear conditioning, Y-maze, and actimetry) and brain anatomy (high-resolution magnetic resonance imaging) of 6- to 8-week-old Swiss mice exposed or not exposed to GA from 4 to 10 days old were evaluated. A second study was a complementary analysis from the preexisting APprentissages EXécutifs et cerveau chez les enfants d'âge scolaire (APEX) cohort to assess the replicability of our data in humans. The behaviors (behavior rating inventory of executive function, emotional control, and working memory score, Backward Digit Span, and Raven 36) and brain anatomy (high-resolution magnetic resonance imaging) were compared in 102 children 9 to 10 years of age exposed or not exposed to a single GA (surgery) during infancy. Results: The animal study revealed chronic exacerbated fear behavior in the adult mice (95% confidence interval [CI], 4-80; P = .03) exposed to postnatal GA; this was associated with an 11% (95% CI, 7.5-14.5) reduction of the periaqueductal gray matter (P = .046). The study in humans suggested lower emotional control (95% CI, 0.33-9.10; P = .06) and a 6.1% (95% CI, 4.3-7.8) reduction in the posterior part of the right inferior frontal gyrus (P = .019) in the children who had been exposed to a single GA procedure. Conclusions: The preclinical and clinical findings of these independent studies suggest lasting effects of early life exposure to anesthetics on later emotional control behaviors and brain structures.

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Fichiers liés : Salaun et al-2023.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Célina DucrouxLaurent DerexMikaïl NourredineJulie HaesebaertMarielle BuissonWalid AlesefirW. BoisseauNicole DaneaultYan DeschaintreJose Danilo B. DiestroOmer EkerJohanna EnelingLaura GioiaDaniella IancuGrégory JacquinCéline OdierChristian StapfJean RaymondD. RoyA. WeillBertrand LapergueAlexandre PoppeMichel PiotinRaphael BlancHocine Redjem Simon EscalardJean-Philippe DesillesFrançois DelvoyeStanislas SmajdaBenjamin MaierSolène HebertMikael MazighiMikael ObadiaCandice SabbenPierre SenersIgor RaynouardOvide CorabianuThomas de BrouckerEric ManchonGuillaume TaylorMalek Ben MaachaLaurie-Anne ThionAugustin LeclerJulien SavatovskyAdrien WangSerge EvrardMaya TchikviladzeNadia AjiliBertrand LapergueDavid Weisenburger-LileLucas GorzaGéraldine BuardOguzhan CoskunArturo ConsoliFederico Di MariaGeorges RodeshSergio ZimatoreMorgan LeguenJulie GratieuxFernando PicoHaja RakotoharinandrasanaPhilippe TassanRoxanna PollSylvie MarinierNorbert NighoghossianRoberto RivaOmer EkerFrancis TurjmanLaurent DerexTae-Hee ChoLaura MechtouffAnne-Claire LukaszewiczFrédéric PhilippeauSerkan CakmakKarine Blanc-LasserreAnne-Evelyne ValletGaultier MarnatFlorent GarielXavier BarreauJérôme BergePatrice MenegonIgor SibonLudovic LucasStéphane OlindoPauline RenouSharmila SagnierMathilde PoliSabrina DebruxellesFrançois RouanetThomas TourdiasJean-Sebastien LiegeyPierre BriauNicolas PangonRomain BourcierLili DétrazBenjamin Daumas-DuportPierre-Louis AlexandreMonica RoyCédric LenobleHubert DesalBenoît GuillonSolène de GaalonCécile PreterreBenjamin GorySerge BracardRené AnxionnatMarc BraunAnne-Laure DerelleRomain TonneletLiang LiaoFrançois ZhuEmmanuelle SchmittSophie PlanelSébastien RichardLisa HumbertjeanGioia MioneJean-Christophe LacourNolwenn Riou-ComteGérard AudibertMarcela VoicuIonel AlbMarie ReitterMadalina BrezeanuAgnès MassonAdriana TabarnaIona PodarFrancisco Macian-MontoroSuzanna SalemeCharbel MounayerAymeric RouchaudVincent CostalatCaroline ArquizanCyril DargazanliGrégory GascouPierre-Henri LefèvreImad DerrazCarlos RiquelmeNicolas GaillardIsabelle MourandLucas CortiFederico CagnazzoAdrien ter SchiphorstEugene FrancoisStéphane VannierJean-Christophe FerreHelene RaoultThomas RonziereMaria LassaleChristophe PayaJean-Yves GauvritClément TracolSophie Langnier-LemercierYves SamsonCharlotte RossoAnne LegerSandrine DeltourFrédéric ClarençonEimad ShotarLaurent SpelleChristian DenierOlivier ChassinVanessa ChalumeauJildaz CaroffOlivier ChassinLaura VendittiOlivier NaggaraWagih Ben HassenGrégoire BoulouisChristine Rodriguez-RégentDenis TrystramBasile KerlerouxGuillaume TurcValérie DomigoCatherine LamyJulia BirchenallClothilde IsabelFrançois LunAlain ViguierChristophe CognardAnne Christine JanuelJean-Marc OlivotNicolas RaposoFabrice BonnevilleJean François AlbucherLionel CalviereJean DarcourtPhilippe TallGuillaume BellangerLouis FontaineEmmanuel TouzeCharlotte BarbierRomain SchneckenburgerMarion BoulangerJulien CogezSophie GuettierSerge TimsitJean-Christophe GentricJulien OgnardFrancois Mathias MerrienOzlem Ozkul WermesterEvelyne MassardierChrysanthi PapagiannakiFrédéric BourdainPatricia BernadyLaurent Lagoarde-SegotHélène CailliezLouis VeunacDavid HigueValérie WolffRaoul PopRémi BeaujeuxMihoc Dan-SorinMonica ManisorAnthony Le BrasSarah EvainArnaud Le GuenSebastian RichterRegis HubrechtStéphanie DemaslesBruno BarrosoDenis SablotGeoffroy FarouilMaxime TardieuPhilippe SmadjaSabine AptelIan Seiler
• Organismes : Université de Montréal Research on Healthcare Performance Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Service Hospitalo-Universitaire de Pharmaco-Toxicologie [Bron] Service Hospitalo-Universitaire de Pharmaco-Toxicologie [Bron] Centre d’Investigation Clinique de Lyon Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé Modeling & analysis for medical imaging and Diagnosis Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Centre Hospitalier de l'Université de Montréal Hôpital Foch [Suresnes]
• Publié dans Journal de Neuroradiologie / Journal of Neuroradiology le 26/10/2020

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Résumé : Background: Patients with pre-stroke disability, defined as a modified Rankin Scale (mRS) ≥3, were excluded from most trials of endovascular thrombectomy (EVT) for acute stroke. We sought to evaluate the prognostic factors associated with favorable outcome in stroke patients with known disability undergoing EVT, and the impact of successful reperfusion. Methods: Consecutive acute stroke patients with pre-stroke disability, undergoing EVT, were retrospectively collected between 2016 to 2019 from a Canadian cohort and a multicenter French cohort (Endovascular Treatment in Ischemic Stroke registry-ETIS). Favorable outcome was defined as an mRS equal to pre-stroke mRS. Patients achieving successful reperfusion (defined as a modified Thrombolysis in Cerebral Infarction score of 2b/3) were compared with patients without successful reperfusion to determine if successful EVT was associated with better functional outcomes. Results: Among 6220 patients treated with EVT, 280 (4.5%) patients with a pre-stroke mRS ≥3 were included. Sixty-one patients (21.8%) had a favorable outcome and 146 (52.1%) died at 3 months. Patients with successful reperfusion had a higher proportion of favorable 90-day mRS (27.6% versus 19.6%, p = 0.025) and a lower mortality (48.3% versus 69.6%, p = 0.008) than patients without successful reperfusion. After adjusting for baseline prognostic factors, successful reperfusion defined by TICI ≥2b was associated with favorable functional outcome (OR 3.16 CI95% [1.11-11.5]; p 0.048). Conclusion: In patients with pre-stroke disability, successful reperfusion is associated with a greater proportion of favorable outcome and lower mortality.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : David MalkaNicolas GirardDavid M SmadjaChristine ChevreauStéphane CulineAnne LesurRoman RouzierFrançois RozetJean-Philippe SpanoJean-Yves Blay
• Organismes : Dynamique des cellules tumorales Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans Bulletin du Cancer le 01/11/2020

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Résumé : La thrombose associée au cancer est une complication fréquente résultant de divers mécanismes vasculaires liés au cancer, au traitement antitumoral et au patient, et qui est associée à un mauvais pronostic. L’anticoagulation recommandée, en prévention ou en traitement curatif, repose essentiellement sur les héparines de bas poids moléculaire (HBPM) ou les anticoagulants oraux directs. L’enjeu de la thromboprophylaxie, pour laquelle les HBPM sont privilégiées en raison d’un moindre risque hémorragique notamment en cas de tumeur digestive endoluminale ou urothéliale en place, demeure l’identification des patients à risque. La question majeure concernant la prise en charge des thromboses avérées est le choix de l’anticoagulant. Du fait de la simplicité de leur administration, les anticoagulants oraux directs apparaissent comme attractifs, et les études randomisées les ayant évalués ont montré leur efficacité. Cependant, ces études sont limitées par le profil des patients inclus qui ne sont pas toujours représentatifs des situations en vraie vie, notamment concernant les cancers à risque hémorragique et certains traitements antitumoraux, inhibiteurs de tyrosine kinase notamment, qui peuvent interagir avec les anticoagulants oraux directs et en modifier potentiellement la biodisponibilité. Les recommandations disponibles soulignent ces précautions et renvoient in fine à des décisions au cas par cas. Cet article a pour but de guider l’oncologue dans son choix d’anticoagulation à travers une série de réponses documentées et pragmatiques aux questions qui se posent face à un patient pris en charge pour une tumeur solide et potentiellement à risque de thrombose ou avec une thrombose établie.

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Fichiers liés : [Prophylaxis and management of cancer-associated thrombosis Practical issues about anticoagulant use]..pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Aiste LengvenyteRobertas StrumilaRaoul BelzeauxBruno AouizerateCaroline DubertretEmmanuel HaffenPierre-Michel LlorcaPaul RouxMircea PolosanRaymund SchwanMichel WalterThierry A. d'AmatoDominique JanuelMarion LeboyerFrank BellivierBruno EtainAlvydas NavickasÉmilie OliéPhilippe Courtet
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Vilnius University [Vilnius] Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Vilnius University [Vilnius] Institut de Neurosciences de la Timone Fondation FondaMental [Créteil] Assistance Publique - Hôpitaux de Marseille Institut de Génomique Fonctionnelle Nutrition et Neurobiologie intégrée Centre hospitalier Charles Perrens [Bordeaux] Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Institut de psychiatrie et neurosciences de Paris Hôpital Louis Mourier - AP-HP [Colombes] Fondation FondaMental [Créteil] Centre d'Investigation Clinique de Besançon Université Bourgogne Franche-Comté [COMUE] Fondation FondaMental [Créteil] CHU Clermont-Ferrand Université Clermont Auvergne Fondation FondaMental [Créteil] Centre Hospitalier de Versailles André Mignot Centre de recherche en épidémiologie et santé des populations [GIN] Grenoble Institut des Neurosciences CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble Fondation FondaMental [Créteil] Imagerie Adaptative Diagnostique et Interventionnelle Fondation FondaMental [Créteil] Centre Psychothérapique de Nancy [Laxou] Fondation FondaMental [Créteil] Hopital de Bohars - CHRU Brest Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center Fondation FondaMental [Créteil] Etablissement public de santé de Ville-Evrard [Neuilly-sur-Marne] Fondation FondaMental [Créteil] Institut Mondor de Recherche Biomédicale Assistance publique - Hôpitaux de Paris (AP-HP) Fondation FondaMental [Créteil] CHU Henri Mondor [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Optimisation thérapeutique en Neuropsychopharmacologie Fondation FondaMental [Créteil] Fondation FondaMental [Créteil] Hôpital Lariboisière-Fernand-Widal [APHP] Optimisation thérapeutique en Neuropsychopharmacologie Vilnius University [Vilnius] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Fondation FondaMental [Créteil]
• Publié dans Brain, Behavior, and Immunity le 29/10/2020

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Résumé : Evidences suggest that inflammation is increased in a subgroup of patients with depression. Moreover, increased peripheral inflammatory markers (cells and proteins) are associated with some, but not all depressive symptoms. On the other hand, similar studies on bipolar disorders mainly focused on blood cytokines. Here, we analysed data from a large (N = 3440), well-characterized cohort of individuals with bipolar disorder using Kendall partial rank correlation, multivariate linear regression, and network analyses to determine whether peripheral blood cell counts are associated with depression severity, its symptoms, and dimensions. Based on the self-reported 16-Item Quick Inventory of Depressive Symptomatology questionnaire scores, we preselected symptom dimensions based on literature and data-driven principal component analysis. We found that the counts of all blood cell types were only marginally associated with depression severity. Conversely, white blood cell count was significantly associated with the sickness dimension and its four components (anhedonia, slowing down, fatigue, and appetite loss). Platelet count was associated with the insomnia/restlessness dimension and its components (initial, middle, late insomnia and restlessness). Principal component analyses corroborated these results. Platelet count was also associated with suicidal ideation. In analyses stratified by sex, the white blood cell count-sickness dimension association remained significant only in men, and the platelet count-insomnia/restlessness dimension association only in women. Without implying causation, these results suggest that peripheral blood cell counts might be associated with different depressive symptoms in individuals with bipolar disorder, and that white blood cells might be implicated in sickness symptoms and platelets in insomnia/agitation and suicidal ideation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Léa MerioJohan ChanalMarie JachietValérie PourcherJean Philippe ArnaultChristelle JouhetBrigitte Milpied-HomsiIsabelle Bourgault-VilladaFrancois AubinFrédéric CauxSébastien FouéréÉric VicautMarie Beylot-BarryOlivier Chosidow
• Organismes : Institut Cochin Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Service de dermatologie [CHU d'Amiens-Picardie] Centre Hospitalier Universitaire de Bordeaux Institut Cochin Department of Dermatology Service de dermatologie [Avicenne] Hopital Saint-Louis [AP-HP] Paris-Centre de Recherche Cardiovasculaire Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal Centre d'Investigation Clinique Henri Mondor
• Publié dans Journal of the European Academy of Dermatology and Venereology le 27/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Pinto SergeAdelheid NebelJörn RauRobert EspesserPauline MaillochonOliver NiebuhrPaul KrackTatiana WitjasAlain GhioMarie‐charlotte CuarteroLars TimmermannAlfons SchnitzlerHelke HesekampNiklaus MeierJulia MüllnerThomas HälbigBettina MöllerSteffen PaschenLaura PaschenJens VolkmannMichael BarbeGereon FinkJohannes BeckerPaul RekerAndrea KühnGerd‐helge SchneiderValérie FraixEric SeigneuretAndrea KistnerOlivier J. RascolChristine Brefel-CourbonFabienne Ory MagneChristian HartmannLars WojteckiAnne FradetDavid MaltêtePhilippe DamierSéverine Le DilyFriederike Sixel-DöringPetra BeneckeDaniel WeissTobias WächterMarcus PinskerJean RégisStéphane ThoboisGustavo PoloJean‐luc HouetoAndreas HartmannKarina KnudsenMarie VidailhetMichael SchüpbachGünther Deuschl
• Organismes : Laboratoire Parole et Langage University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein Philipps Universität Marburg = Philipps University of Marburg Laboratoire Parole et Langage Laboratoire Parole et Langage Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel [GIN] Grenoble Institut des Neurosciences Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Laboratoire Parole et Langage Laboratoire Parole et Langage University Hospital of Cologne [Cologne] Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein University Hospital of Cologne [Cologne] University Hospital of Cologne [Cologne] University Hospital of Cologne [Cologne] University Hospital of Cologne [Cologne] Freie Universität Berlin = Free University of Berlin Freie Universität Berlin = Free University of Berlin [GIN] Grenoble Institut des Neurosciences [GIN] Grenoble Institut des Neurosciences [GIN] Grenoble Institut des Neurosciences Toulouse NeuroImaging Center Département Neurologie [CHU Toulouse] Département Neurologie [CHU Toulouse] Toulouse NeuroImaging Center Toulouse NeuroImaging Center Département Neurologie [CHU Toulouse] Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Service de neurologie [Rouen] Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau Centre d’Investigation Clinique de Nantes Centre d’Investigation Clinique de Nantes Paracelsus-Elena-Klinik, Kassel, Germany. Paracelsus-Elena-Klinik, Kassel, Germany. Universitätsklinikum Tübingen = University Hospital of Tuebingen Universitätsklinikum Tübingen = University Hospital of Tuebingen Universitäts Klinikum Freiburg = University Medical Center Freiburg Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] Hôpital neurologique et neurochirurgical Pierre Wertheimer [CHU - HCL] CIC de Poitiers – Centre d'investigation clinique de Poitiers (CIC 1402) Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] University Medical Center of Schleswig–Holstein = Universitätsklinikum Schleswig-Holstein
• Publié dans Movement Disorders le 31/10/2020

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Résumé : Background: The EARLYSTIM trial demonstrated for Parkinson ’ s disease patients with early motor complications that deep brain stimulation of the subthalamic nucleus (STN-DBS) and best medical treatment (BMT) was superior to BMT alone. Objective: This prospective, ancillary study on EARLYSTIM compared changes in blinded speech intelligibility assessment between STN-DBS and BMT over 2 years, and secondary outcomes included non-speech oral movements (maximum phonation time [MPT], oral diadochokinesis), physician- and patient-reported assessments. Methods: STN-DBS (n = 102) and BMT (n = 99) groups underwent assessments on/off medication at baseline and 24 months (in four conditions: on/off medication, ON/OFF stimulation — for STN-DBS). Words and sentences were randomly presented to blinded listeners, and speech intelligibility rate was measured. Statistical analyses compared changes between the STN-DBS and BMT groups from baseline to 24 months. Results: Over the 2-year period, changes in speech intelligibility and MPT, as well as patient-reported outcomes, were not different between groups, either off or on medication or OFF or ON stimulation, but most outcomes showed a nonsignificant trend toward worsening in both groups. Change in oral diadochokinesis was significantly different between STN-DBS and BMT groups, on medi- cation and OFF STN-DBS, with patients in the STN-DBS group performing slightly worse than patients under BMT only. A signal for clinical worsening with STN-DBS was found for the individual speech item of the Unified Parkinson’ s Disease Rating Scale, Part III. Conclusion: At this early stage of the patients ’ disease, STN-DBS did not result in a consistent deterioration in blinded speech intelligibility assessment and patient-reported communication, as observed in studies of advanced Parkinson’ s Disease.

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Fichiers liés : Movement Disorders - 2023 Pinto.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Aurelie LeboyanFlorence EsselinAnne‐laure BascouClaire DuflosIoana IonMahmoud CharifGiovanni CastelnovoClarisse Carra DallièreXavier AyrignacPhilippe KerschenMohamed ChbichebLudovic NguyenAlexandre MariaPhilippe GuilpainMathilde CarriereNicolas Menjot de ChampfleurThierry VincentAlexandre JentzerPierre LabaugeJérôme J. DevauxGuillaume Taieb
• Organismes : Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier de Luxembourg [Luxembourg] Centre Hospitalier de Narbonne Centre Hospitalier Saint Jean de Perpignan Hôpital Saint Eloi [CHU Montpellier] Hôpital Saint Eloi [CHU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Hôpital Saint Eloi [CHU Montpellier] Hôpital Saint Eloi [CHU Montpellier] Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle Centre Hospitalier Régional Universitaire [Montpellier] Institut de Génomique Fonctionnelle
• Publié dans European Journal of Neurology le 22/10/2020

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Résumé : Background and purpose: In addition to combined central and peripheral demyelination, other immune diseases could involve both the central nervous system (CNS) and peripheral nervous system (PNS). Methods: To identify immune-mediated diseases responsible for symptomatic combined central/peripheral nervous system involvement (ICCPs), we conducted a multicentric retrospective study and assessed clinical, electrophysiological, and radiological features of patients fulfilling our ICCP criteria. Results: Thirty patients (20 males) were included and followed during a median of 79.5 months (interquartile range [IQR] = 43-145). The median age at onset was 51.5 years (IQR = 39-58). Patients were assigned to one of four groups: (i) monophasic disease with concomitant CNS/PNS involvement including anti-GQ1b syndrome (acute polyradiculoneuropathy + rhombencephalitis, n = 2), checkpoint inhibitor-related toxicities (acute polyradiculoneuropathy + encephalitis, n = 3), and anti-glial fibrillary acidic protein astrocytopathy (subacute polyradiculoneuropathy and meningoencephalomyelitis with linear gadolinium enhancements, n = 2); (ii) chronic course with concomitant CNS/PNS involvement including paraneoplastic syndromes (ganglionopathy/peripheral hyperexcitability + limbic encephalitis, n = 4); (iii) chronic course with sequential CNS/PNS involvement including POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) syndrome (polyradiculoneuropathy + strokes, n = 2), histiocytosis (polyradiculoneuropathy + lepto-/pachymeningitis, n = 1), and systemic vasculitis (multineuropathy + CNS vasculitis/pachymeningitis, n = 2); and (iv) chronic course with concomitant or sequential CNS/PNS involvement including combined central and peripheral demyelination (polyradiculoneuropathy + CNS demyelinating lesions, n = 10) and connective tissue diseases (ganglionopathy/radiculopathy/multineuropathy + limbic encephalitis/transverse myelitis/stroke, n = 4). Conclusions: We diagnosed nine ICCPs. The timing of central and peripheral manifestations and the disease course help determine the underlying immune disease. When antibody against neuroglial antigen is identified, CNS and PNS involvement is systematically concomitant, suggesting a common CNS/PNS antigen and a simultaneous disruption of blood-nerve and blood-brain barriers.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Josefina LingM. ScardiaJean-Louis PrieurL. PansecchiR. ArgyleEric AristidiA. ZanuttaLouis AbbePhilippe BendjoyaJean-Pierre RivetDavid VernetLuca Maccarini
• Organismes : Universidade de Santiago de Compostela [España] = University of Santiago de Compostela [Spain] = Université de Saint-Jacques-de-Compostelle [Espagne] INAF - Osservatorio Astronomico di Brera Institut de recherche en astrophysique et planétologie INAF - Osservatorio Astronomico di Brera Laboratoire Hippolyte Fizeau Université Nice Sophia Antipolis (1965 - 2019) Observatoire de la Côte d'Azur
• Publié dans Information Circular - IAU Commission G1 Double Stars le 09/11/2019

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Fichiers liés : cir209.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/02/2023
• Auteurs : Abigail PickardJean-Pierre ThibautKaat PhilippeJérémie Lafraire
• Organismes : Institut Lyfe Research & Innovation Centre (ex-Institut Paul Bocuse Research Centre) Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] Centre des Sciences du Goût et de l'Alimentation [Dijon] Université Bourgogne Franche-Comté [COMUE] Institut Lyfe Research & Innovation Centre (ex-Institut Paul Bocuse Research Centre)
• Publié dans Journal of Experimental Child Psychology le 25/10/2020

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Résumé : Previous research established that children with poorer taxonomic knowledge in the food domain display increased levels of food rejection. However, the food domain heavily lends itself to script and thematic conceptual knowledge (e.g., pancakes at breakfast), to which young children already attend. This series of studies investigated the development of conceptual knowledge, specifically in the food domain, and the link with food rejection. Study 1 used a nonconflicting triad task testing children’s knowledge of four subtypes of script and thematic associations (food–food pairs, food–utensil pairs, event scripts, and meal scripts) with children aged 3–6 years living in the United States (18 males and 14 females). Study 2 employed the same design along with a measure of food rejection in 3- to 6-year-olds living in France (67 males and 62 females). There was significant conceptual development in both groups, but thematic food concepts are acquired earlier than meal script concepts. Study 3 investigated the link between thematic and script cross-classification and food rejection in 39 females and 33 males living in France (4- to 7-year-olds). Results demonstrate that children as young as 3 years old are already attending to thematic and script structures to inform food-based decision making. Even more critically, Study 3 showed that increased food rejection tendencies are negatively related to script and thematic understanding in the food domain. Such seminal studies illustrate the importance of conceptual knowledge in children’s interpretation and acceptance of food, highlighting promising avenues for knowledge-based interventions to foster dietary variety.

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Fichiers liés : pickard_2023_vol226_105546_j_exp_child_psychol.pdf

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