Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 25/12/2022
• Auteurs : Laura Amado-RodríguezRaquel Rodríguez-GarciaGiacomo BellaniTài PhamEddy FanFabiana MadottoJohn G LaffeyGuillermo M AlbaicetaAntonio PesentiLaurent BrochardAndres EstebanLuciano GattinoniFrank van HarenAnders LarssonDaniel F McauleyMarco RanieriGordon RubenfeldB Taylor ThompsonHermann WriggeArthur S SlutskyFernando RiosFrank van HarenThierry SottiauxPieter DepuydtFredy S LoraLuciano Cesar AzevedoGuillermo BugedoHaibo QiuMarcos GonzalezJuan SileskyVladimir CernyJonas NielsenManuel JibajaHermann WriggeDimitrios MatamisJorge Luis RaneroPravin AminS M HashemianKevin ClarksonKiyoyasu KurahashiAsisclo VillagomezAmine Ali ZeggwaghLeo M HeunksJon Henrik LaakeJose Emmanuel PaloAntero Do Vale FernandesDorel SandescYaasen ArabiVesna BumbasierevicNicolas NinJose A LorenteAnders LarssonLise PiquilloudFekri AbrougDaniel F McauleyLia McnameeJavier HurtadoEd BajwaGabriel DémpaireHektor SulaLordian NunciAlma CaniAlan ZazuChristian DelleraCarolina S InsaurraldeSanatorio Las LomasSan IsidroRisso V AlejandroJulio DaldinMauricio VinzioRuben O FernandezLuis P CardonnetLisandro R BettiniMariano Carboni BissoEmilio M OsmanMariano G SettenPablo LovazzanoJavier AlvarezVeronica VillarNorberto C PozoNicolas GrubissichGustavo A PlotnikowDaniela N VasquezSantiago IlutovichNorberto TiribelliAriel ChenaCarlos A PellegriniMaría G SaenzElisa EstenssoroMatias BrizuelaHernan GianinettoPablo E GomezValeria I CerratoMarco G BezziSilvina A BorelloFlavia A LoiaconoAdriana M FernandezSerena KnowlesClaire ReynoldsDeborah M InskipJennene J MillerJing KongChristina WhiteheadShailesh BihariAylin SevenAmanda KrstevskiHelen J RodgersRebecca T MillarToni E MckennaIrene M BaileyGabrielle C HanlonAnders AnemanJoan M LynchRaman AzadJohn NealPaul W WoodsBrigit L RobertsMark R KolHelen S WongKatharina C RissThomas StaudingerXavier WitteboleCaroline BerghePierre A BulpaAlain M DiveRik VerstraeteHerve LebbinckPieter DepuydtJoris VermassenPhilippe MeerssemanHelga CeunenJonas I RosaDaniel O BeraldoClaudio PirasAdenilton M RampinelliAntonio P Nassar JrSergio MatalounMarcelo MoockMarlus M ThompsonClaudio H GonçalvesAna Carolina P AntônioAline AscoliRodrigo S BiondiDanielle C FonteneleDanielle NobregaVanessa M SalesAhmad Yazid Binhjabul WahabMaizatul IsmailSuresh ShindheJohn G LaffeyFrancois BeloncleKyle G DaviesRob CironeVenika ManoharanMehvish IsmailEwan C GoligherMandeep JassalErin NishikawaAreej JaveedGerard CurleyNuttapol RittayamaiMatteo ParottoNiall D FergusonSangeeta MehtaJenny KnollAntoine PronovostSergio CanestriniAlejandro R BruhnPatricio H GarciaFelipe A AliagaPamela A FaríasJacob S YumhaClaudia A OrtizJavier E SalasAlejandro A SaezLuis D VegaEduardo F LabarcaFelipe T MartinezNicolás G CarreñoPilar LoraHaitao LiuHaibo QiuLing LiuRui TangXiaoming LuoYouzhong AnHuiying ZhaoYan GaoZhe ZhaiZheng L YeWei WangWenwen LiQingdong LiRuiqiang ZhengWenkui YuJuanhong ShenXinyu LiTao YuWeihua LuYa Q WuXiao B HuangZhenyang HeYuanhua LuHui HanFan ZhangRenhua SunHua X WangShu H QinBao H ZhuJun ZhaoJian LiuBin LiJing L LiuFa C ZhouQiong J LiXing Y ZhangZhou Li-XinQiang Xin-HuaLiangyan JiangYuan N GaoXian Y ZhaoYuan Y LiXiao L LiChunting WangQingchun YaoRongguo YuKai ChenHuanzhang ShaoBingyu QinQing Q HuangWei H ZhuAi Y HangMa X HuaYimin LiYonghao XuYu D DiLong L LingTie H QinShou H WangJunping QinYi HanSuming ZhouMonica P VargasJuan I Silesky JimenezManuel a González RojasJaime E SolisquesadaChristian M Ramirez-AlfaroJan MácaPeter SklienkaJakob GjedstedAage ChristiansenJonas NielsenBoris G VillamaguaIguel LlanoPhilippe BurtinGautier BuzancaisPascal BeuretNicolas PelletierSatar MortazaAlain MercatJonathan ChellySébastien JochmansNicolas TerziCédric DaubinGuillaume CarteauxNicolas de ProstJean-Daniel ChicheFabrice DaviaudMuriel FartoukhGuillaume BarberetJerome BiehlerJean DellamonicaDenis DoyenJean-Michel ArnalAnais BriquetSami HraiechLaurent PapazianArnaud FollinDamien RouxJonathan MessikaEvangelos KalaitzisLaurence DangersAlain CombesGaetan BéduneauDorothée CarpentierElie ZogheibHervé DupontSylvie RicomeFrancesco L SantoliSebastien L BessetPhilippe MichelBruno GeléePierre-Eric DaninBernard GoubauxPhilippe J CrovaNga T PhanFrantz BerkelmansJulio C BadieRomain TapponnierJosette GallySamy KhebbebJean-Etienne HerbrechtFrancis SchneiderPierrelouis M DeclercqJean-Philippe RigaudJacques DuranteauAnatole HarroisRussell ChabanneJulien MarinCharlene BigotSandrine ThibaultMohammed GhaziMessabi BoukhaznaSalem Ould ZeinJack R RichecoeurDaniele M CombauxFabien GrelonCharlene Le MoalElise P SauvadetAdrien RobineVirginie LemialeDanielle ReuterMartin DresAlexandre DemouleDany Goldgran-ToledanoLoredana BaboiClaude GuérinRalph LohnerJens KraßlerSusanne SchäferKai D ZacharowskiPatrick MeybohmAndreas W ReskePhilipp SimonHansbernd F HopfMichael SchuetzThomas BaltusMetaxia N PapanikolaouTheonymfi G PapavasilopoulouGiannis A ZacharasVasilis OurailogloyEleni K MouloudiEleni V MassaEva O NagyElectra E StamouEllada V KiourtzievaMarina A OikonomouLuis E AvilaCesar A CortezJohanna E CitalánSameer A JogSafal D SableBhagyesh ShahMohan GurjarArvind K BaroniaMohammedfaruk MemonRadhakrishnan MuthuchellappanVenkatapura J RameshAnitha ShenoyRamesh UnnikrishnanSubhal B DixitRachana V RhayakarNagarajan RamakrishnanVallish K BhardwajHeera L MahtoSudha V SagarVijayanand PalaniswamyDeeban GanesanSeyed Mohammadreza HashemianHamidreza JamaatiFarshad HeidariEdel A MeaneyAlistair NicholKarl M KnapmanDonall O’croininEimhin S DunneDorothy M BreenKevin P ClarksonRola F JaafarRory DwyerFahd AmirOlaitan O AjetunmobiAogan C O’muircheartaighColin S BlackNuala TreanorDaniel V CollinsWahid AltafGianluca ZaniMaurizio FusariSavino SpadaroCarlo A VoltaRomano GrazianiBarbara BrunettiniSalvatore PalmesePaolo FormentiMichele UmbrelloAndrea LombardoElisabetta PecciMarco BotteriMonica SavioliAlessandro ProttiAlessia MatteiLorenzo SchiavoniAndrea TinnirelloManuel TodeschiniAntonino GiarratanoAndrea CortegianiSara SherAnna RossiMassimo M AntonelliLuca M MontiniPaolo CasalenaSergio ScafettiGiovanna PanarelloGiovanna OcchipintiNicolò PatronitiMatteo PozziRoberto R BiscioneMichela M PoliFerdinando RaimondiDaniela AlbieroGiulia CrapelliEduardo BeckVincenzo PotaVincenzo SchiavoneAlexandre MolinFabio TarantinoGiacomo MontiElena FratiLucia MirabellaGilda CinnellaTommaso FossaliRiccardo ColomboPierpaolo TerragniIlaria PattarinoFrancesco MojoliAntonio BraschiErika E BorottoAndrea N CracchioloDaniela M PalmaFrancesco RaponiGiuseppe FotiEttore R VascottoAndrea CoppadoroLuca BrazziLeda FlorisGiorgio A IottiAaron VentiOsamu YamaguchiShunsuke TakagiHiroki N MaeyamaEizo WatanabeYoshihiro YamajiKazuyoshi ShimizuKyoko ShiozakiSatoru FutamiSekine RyosukeKoji SaitoYoshinobu KameyamaKeiko UenoMasayo IzawaNao OkudaHiroyuki SuzukiTomofumi HarasawaMichitaka NasuTadaaki TakadaFumihito ItoShin NunomiyaKansuke KoyamaToshikazu AbeKohkichi AndohKohei KusumotoAkira HirataAkihiro TakabaHiroyasu KimuraShuhei MatsumotoUshio HigashijimaHiroyuki HondaNobumasa AokiHiroshi ImaiYasuaki OginoIchiko MizuguchiKazuya IchikadoKenichi NittaKatsunori MochizukiTomoaki HashidaHiroyuki TanakaTomoyuki NakamuraDaisuke NiimiTakeshi UedaYozo KashiwaAkinori UchiyamaOlegs SabelnikovsPeteris OssYoussef HaddadKong Y LiewSilvio A Ñamendys-SilvaYves D Jarquin-BadiolaLuis A Sanchez-HurtadoSaira S Gomez-FloresMaria C MarinAsisclo J VillagomezJordana S LemusJonathan M FierroMavy Ramirez CervantesFrancisco Javier Flores MejiaDulce DectorAlejandro RojasDaniel R GonzalezClaudia R EstrellaJorge R Sanchez-MedinaAlvaro Ramirez-GutierrezFernando G GeorgeJanet S AguirreJuan A BuensusesoManuel PoblanoTarek DendaneAmine Ali ZeggwaghHicham BalkhiMina ElkhayariNacer SamkaouiHanane EzzouineAbdellatif BenslamaMourad AmorWajdi MaazouziNedim CimicOliver BeckMonique M BrunsJeroen A SchoutenMyra RiniaMonique RaaijmakersLeo M HeunksHellen M van WezelSerge J HeinesUlrich StrauchMarc P BuiseFabienne D SimonisMarcus J SchultzJennifer C GoodsonTroy S BrowneLeanlove NavarraAnna HuntRobyn A HutchisonMathew B BaileyLynette NewbyColin McarthurMichael KalkoffAlex McleodJonathan CasementDanielle J HackingFinn H AndersenMerete S DolvaJon H LaakeAndreas Barratt-DueKim Andre L NoremarkEldar SøreideBrit Å SjøbøAnne B GuttormsenHector H LeonyoshidoRonald Zumaran AguilarFredy a Montes OscanoaAlain U AlisasisJoanne B RoblesRossini Abbie B Pasanting-LimBeatriz C TanPawel AndruszkiewiczKarina JakubowskaCristina M CoxoAntónio M AlvarezBruno S OliveiraGustavo M MontanhaNelson C BarrosCarlos S PereiraAntónio M MessiasJorge M MonteiroAna M AraujoNuno T CatorzeSusan M MarumMaria J BouwRui M GomesVania A BritoSilvia CastroJoana M EstilitaFilipa M BarrosIsabel M SerraAurelia M MartinhoDana R TomescuAlexandra MarcuOvidiu H BedreagMarius PapuricaDan E CorneciSilvius Ioan NegoitaEvgeny GrigorievAlexey I GritsanAndrey A GazenkampfGhaleb AlmekhlafiMohamad M AlbarrakGhanem M MustafaKhalid A MaghrabiNawal SalahuddinTharwat M AisaAhmed S AljabbaryEdgardo TabhanYaseen M ArabiYaseen M ArabiOlivia A TrinidadHasan M Al DorziEdgardo E TabhanVesna BumbasirevicBojan JovanovicStefan BolonOliver SmithJordi ManceboHernan Aguirre-BermeoJuan C Lopez-DelgadoFrancisco EsteveGemma RialpCatalina FortezaCandelaria de HaroAntonio ArtigasGuillermo M AlbaicetaSara de Cima-IglesiasLeticia Seoane-QuirogaAlexandra Ceniceros-BarrosAntonio L RuizaguilarLuis M Claraco-VegaJuan Alfonso SolerMaria del CarmenlorenteCecilia HermosaFederico GordoMiryam PrietogonzálezJuan B López-MessaManuel P PerezCesar P PerezRaquel Montoiro AllueFerran RochecampoMarcos Ibañez-SantacruzSusana TempranoMaria C PintadoRaul de PabloPilar Ricart Aroa GómezSilvia Rodriguez RuizSilvia Iglesias MolesM Teresa JuradoAlfons ArizmendiEnrique A PiacentiniNieves FrancoTeresa HonrubiaMeisy Perez ChengElena Perez LosadaJavier BlancoLuis J YusteCecilia Carbayo-GorrizFrancisca G Cazorla-BarranqueroJavier G AlonsoRosa S AldaÁngela AlgabaGonzalo NavarroEnrique CereijoEsther Diaz-RodriguezDiego Pastor MarcosLaura Alvarez MonteroLuis Herrera ParaRoberto Jimenez SanchezMiguel Angel Blasco NavalpotroRicardo Diaz AbadRaquel Montiel GonzálezDácil Parrilla ToribioAlejandro G CastroMaria Jose D ArtigaOscar PenuelasTomas P RoserMoreno F OlgaElena Gallego CurtoRocío Manzano SánchezVallverdu P ImmaGarcia M ElisabetLaura ClaveriasMonica MagretAna M PellicerLucia L RodriguezJesús Sánchez-BallesterosÁngela González-SalamancaAntonio G JimenezFrancisco P HuertaJuan Carlos J Sotillo DiazEsther Bermejo LopezDavid D Llinares MoyaAlec a Tallet AlfonsoPalazon Sanchez Eugenio LuisPalazon Sanchez CesarSánchez I RafaelCorcoles G VirgilioNoelia N RecioRichard O AdamssonChristian C RylanderBernhard HolzgraefeLars M BromanJoanna WessberghLinnea PerssonFredrik SchiölerHans KedelvAnna Oscarsson TibblinHenrik AppelbergLars HedlundJohan HellebergKarin E ErikssonRita GlietschNiklas LarssonIngela NygrenSilvia L NunesAnna-Karin MorinThomas KanderAnne AdolfssonHervé O ZenderCorinne Leemann-RefondiniSouheil ElatrousSlaheddine BouchouchaImed ChoucheneIslem OuanesAsma Ben SouissiSalma KamounOktay DemirkiranMustafa AkerEmre ErbabacanIlkay CeylanNermin Kelebek GirginMenekse OzcelikNecmettin ÜnalBasak Ceyda MecoOnat O AkyolSuleyman S DermanBarry KennedyKen ParharLatha SrinivasaLia McnameeDanny McauleyPhil HopkinsClare MellisVivek KakarDan HadfieldAndre VercueilKaushik BhowmickSally K HumphreysAndrew FergusonRaymond MckeeAshok S RajDanielle A FawkesPhilip WattLinda TwoheyRajeev R JhaMatthew ThomasAlex MortonVarsha KadabaMark J SmithAnil P HormisSanthana G KannanMiriam NamihHenrik ReschreiterJulie CamsooksaiAlek KumarSzabolcs RugonfalviChristopher NuttOrla OneillColette SeasmanGed DempseyChristopher J ScottHelen E EllisStuart MckechniePaula J HuttonNora N Di TomassoMichela N VitaleRuth O GriffinMichael N DeanJulius H CranshawEmma L WillettNicholas IoannouSarah GillisPeter CsabiRosaleen MacfadyenHeidi DawsonPieter D PreezAlexandra J WilliamsOwen BoydLaura Ortiz-Ruiz de GordoaJon BramallSophie SymmondsSimon K ChauTim WenhamTamas SzakmanyPiroska Toth-TarsolyKatie H MccalmanPeter AlexanderLorraine StephensonThomas CollyerRhiannon ChapmanRaphael CooperRussell M AllanMalcolm SimDavid W WrathallDonald A IrvineCharing Kim S ZantuaJohn C AdamsAndrew J BurtenshawGareth P SellorsIngeborg D WeltersKaren E WilliamsRobert J HessellMatthew G OldroydCeri E BattleSuresh PillaiIstvan KajtorMageswaran SivashanmugavelSinead C OkaneAdrian DonnellyAniko D FrigyikJon P CarelessMartin M MayRichard StewartT John TrinderSamantha J HaganJade M ColeCaroline C MacfieAnna T DowlingJavier HurtadoNicolás NinJavier HurtadoEdgardo NuñezGustavo PittiniRuben RodriguezMaría C ImperioCristina SantosAna G FrançaAlejandro EbeidAlberto DeicasCarolina SerraAditya UppalapatiGhassan KamelValerie M BannergoodspeedJeremy R BeitlerSatyanarayana Reddy MukkeraShreedhar KulkarniJohn O Shinn IiiDina GomaaChristopher TainterJarone LeeTomaz MesarDale J YeattsJessica WarrenMichael J LanspaRussel R MillerColin K GrissomSamuel M BrownPhilippe R BauerRyan J GosselinBarrett T KitchJason E CohenScott H BeegleShazia ChoudryRenaud M GueretAiman TulaimatWilliam StiglerHitesh BatraNidhi G HuffKeith D LambTrevor W OettingNicholas M MohrClaine JudyShigeki SaitoFayez M KheirFayez KheirAdam B SchlichtingAngela DelsingDaniel R CrouchMary ElmasriDaniel R CrouchDina IsmailKyle R DreyerThomas C BlakemanDina GomaaRebecca M BaroPeter C HouRaghu SeethalaImo AisikuGalen HendersonGyorgy FrendlSen-Kuang HouRobert L OwensAshley Schomer
• Organismes : Centre de recherche en épidémiologie et santé des populations Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
• Publié dans Journal of Intensive Care le 24/10/2020

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Résumé : Background: Patients with acute respiratory failure caused by cardiogenic pulmonary edema (CPE) may require mechanical ventilation that can cause further lung damage. Our aim was to determine the impact of ventilatory settings on CPE mortality. Methods: Patients from the LUNG SAFE cohort, a multicenter prospective cohort study of patients undergoing mechanical ventilation, were studied. Relationships between ventilatory parameters and outcomes (ICU discharge/ hospital mortality) were assessed using latent mixture analysis and a marginal structural model. Results: From 4499 patients, 391 meeting CPE criteria (median age 70 [interquartile range 59-78], 40% female) were included. ICU and hospital mortality were 34% and 40%, respectively. ICU survivors were younger (67 [57-77] vs 74 [64-80] years, p < 0.001) and had lower driving (12 [8-16] vs 15 [11-17] cmH 2 O, p < 0.001), plateau (20 [15-23] vs 22 [19-26] cmH 2 O, p < 0.001) and peak (21 [17-27] vs 26 [20-32] cmH 2 O, p < 0.001) pressures. Latent mixture analysis of patients receiving invasive mechanical ventilation on ICU day 1 revealed a subgroup ventilated with high pressures with lower probability of being discharged alive from the ICU (hazard ratio [HR] 0.79 [95% confidence interval 0.60-1.05], p = 0.103) and increased hospital mortality (HR 1.65 [1.16-2.36], p = 0.005). In a marginal structural model, driving pressures in the first week (HR 1.12 [1.06-1.18], p < 0.001) and tidal volume after day 7 (HR 0.69 [0.52-0.93], p = 0.015) were related to survival. Conclusions: Higher airway pressures in invasively ventilated patients with CPE are related to mortality. These patients may be exposed to an increased risk of ventilator-induced lung injury.

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Fichiers liés : s40560-022-00648-x.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/12/2022
• Auteurs : Damien CleretMarion GradwohlLucie DekerleAnne-Sophie DrucbertThierry IdziorekDavid PasquierNicolas BlanchemainJulien PayenPierre GuerreschiPhilippe Marchetti
• Organismes : Santé Ingénierie Biologie Saint-Etienne Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 Centre Hospitalier Régional Universitaire [CHU Lille] Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 Lattice Medical [Loos] Institut de Cancérologie de Lorraine - Alexis Vautrin [Nancy] Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 Lattice Medical [Loos] Centre Hospitalier Régional Universitaire [CHU Lille] Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277
• Publié dans Plastic and Reconstructive Surgery, Global Open le 25/10/2020

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Résumé : Background: Use of a tissue-engineering chamber (TEC) for growth of fat flap is a promising approach for breast reconstruction. Here, we evaluated in a preclinical model the effects of radiation on adipose tissue growth either before or after 3D-printed bioresorbable TEC implantation. Methods: Twenty-eight female Wistar rats were distributed into three groups: TEC implantation as nonirradiated controls (G1), TEC insertion followed by irradiation 3 weeks later (G2), and irradiation 6 weeks before TEC insertion (G3). G2 and G3 received 33.3 Gy in nine sessions of 3.7 Gy. Growth of the fat flap was monitored via magnetic resonance imaging. At 6 months after implantation, fat flaps and TECs were harvested for analysis. Results: Irradiation did not alter the physicochemical features of poly(lactic-co-glycolic acid)-based TECs. Compared with G1, fat flap growth was significantly reduced by 1.6 times in irradiated G2 and G3 conditions. In G2 and G3, fat flaps consisted of mature viable adipocytes sustained by CD31+ vascular cells. However, 37% (3 of 8) of the G2 irradiated adipose tissues presented a disorganized architecture invaded by connective tissues with inflammatory CD68 + cells, and the presence of fibrosis was observed. Conclusions: Overall, this preclinical study does not reveal any major obstacle to the use of TEC in a radiotherapy context. Although irradiation reduces the growth of fat flap under the TEC by reducing adipogenesis and inducing inconsistent fibrosis, it does not impact flap survival and vascularization. These elements must be taken into account if radiotherapy is proposed before or after TEC-based breast reconstruction.

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Fichiers liés : preclinical_study_of_radiation_on_fat_flap.31.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/12/2022
• Auteurs : Marion MasingueGorka Fernández-EulateRabab DebsCeline TardCeline LabeyrieSarah Leonard-LouisClaire-Marie DhaenensMary Amélie MassonPhilippe LatourTanya Stojkovic
• Organismes : CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Régional Universitaire [CHU Lille] Service de neurologie [Le Kremlin Bicêtre] CHU Pitié-Salpêtrière [AP-HP] Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 Institut du Cerveau = Paris Brain Institute Service de Biochimie et Biologie Moléculaire Grand Est [HCL, Lyon] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans Revue Neurologique le 31/10/2020

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Résumé : Inherited neuropathies are a heterogeneous group of slowly progressive disorders affecting either motor, sensory, and/or autonomic nerves. Peripheral neuropathy may be the major component of a disease such as Charcot-Marie-Tooth disease or a feature of a more complex multisystemic disease involving the central nervous system and other organs. The goal of this review is to provide the clinical clues orientating the genetic diagnosis in a patient with inherited peripheral neuropathy. This review focuses on primary inherited neuropathies, amyloidosis, inherited metabolic diseases, while detailing clinical, neurophysiological and potential treatment of these diseases.

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Fichiers liés : S0035378722008463.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 22/12/2022
• Auteurs : Fleur DelvaPierre CarcassetPauline MoutonRivana Auguste-VirginieFanny LairezLoic SentilhesPatrick BrochardJean-Philippe Joseph
• Organismes : Bordeaux population health Bordeaux population health Bordeaux population health
• Publié dans International Journal of Environmental Research and Public Health le 01/11/2020

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Résumé : BACKGROUND: Female surgeons are exposed to physical and mental stressors that differ from those of other specialties. We aimed to assess whether female surgeons are more at risk of pregnancy complications than women in other medical specialties. METHODS: We used a cross-sectional electronic survey of female physicians working in the French Region Nouvelle-Aquitaine who were pregnant between 2013 and 2018. A pregnancy complication was defined as the occurrence of miscarriage, ectopic pregnancy, fetal growth restriction, prematurity, fetal congenital malformation, stillbirth, or medical termination of the pregnancy. Multivariate logistic regression models were used to evaluate the risk of pregnancy complications for female surgeons relative to women practicing in other medical specialties. RESULTS: Among the 270 women included, 52 (19.3%) experienced pregnancy complications and 28 (10.4%) were surgeons. In the multivariate analysis, female surgeons had a higher risk of pregnancy complications: adjusted odds ratio = 3.53, 95% confidence interval [1.27-9.84]. CONCLUSION: Further research is necessary to identify the hazards specifically involved in the practice of surgery to be able to propose preventive actions targeted to female surgeons during their pregnancy.

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Fichiers liés : BPH_IJERPH_2022_Delva.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 21/12/2022
• Auteurs : Tao-Chung ChingKeping QiuDi LiZhiyuan 致远 Ren 任Shih-Ping LaiDavid BerryKate PattleRay FuruyaDaniel R. van RossumDoug JohnstonePatrick M KochC.-W. LeeThiem HoangTetsuo HasegawaWoojin KwonPierre BastienChakali EswaraiahJia-Wei WangKyoung Hee KimJihye HwangArchana SoamA.-Ran LyoJunhao LiuValentin Le GouellecDoris ArzoumanianAnthony WhitworthJames Di FrancescoF PoidevinTie 铁 Liu 刘Simon CoudéMehrnoosh TahaniHong-Li LiuTakashi OnakaDalei LiMotohide TamuraZhiwei ChenXindi TangFlorian KirchschlagerTyler BourkeDo-Young ByunMike ChenHuei-Ru Vivien ChenWen Ping ChenJungyeon ChoYunhee ChoiYoungwoo ChoiMinho ChoiA. ChrysostomouEun Jung ChungY. Sophia DaiP. DiepYasuo DoiYan DuanHao-Yuan DuanD. EdenLapo FanciulloJason FiegeLaura FisselErica FranzmannPer FribergRachel FriesenGary FullerTim GledhillSarah GravesJane GreavesMatt GriffinQi-Lao 琦烙 Gu 顾Ilseung HanSaeko HayashiMartin HoudeCharles L H HullTsuyoshi InoueShu-Ichiro InutsukaKazunari IwasakiIl-Gyo JeongVera KönyvesJi-Hyun KangMiju KangJanik KarolyAkimasa KataokaKoji S KawabataFrancisca KemperJongsoo KimMi-Ryang KimShinyoung KimHyosung KimKee-Tae KimGwanjeong KimJason KirkMasato KobayashiTakayoshi KusuneJungmi KwonKevin LacailleChi-Yan LawSang-Sung LeeHyeseung LeeJeong-Eun LeeChin-Fei LeeYong-Hee LeeGuangxing LiHua-Bai LiSheng-Jun 聖鈞 Lin 林Sheng-Yuan LiuXing LuSteve MairsMasafumi 雅文 Matsumura 松村Brenda MatthewsGerald Moriarty-SchievenTetsuya NagataSandhyarani PanigrahyHiroyuki NakanishiNguyen Bich NgocNagayoshi OhashiGeumsook ParkHarriet ParsonsNicolas PerettoFelix PriestleyTae-Soo PyoLei QianRamprasad RaoMark RawlingsJonathan RawlingsBrendan RetterJohn RicherAndrew RigbySarah SadavoyHiro SaitoGiorgio SaviniMasumichi SetaYoshito ShimajiriHiroko ShinnagaYa-Wen TangKohji TomisakaLe Ngoc TramYusuke TsukamotoSerena VitiHongchi WangJintai WuJinjin XieMeng-Zhe YangHsi-Wei YenHyunju YooJinghua YuanHyeong-Sik YunTetsuya ZenkoChuan-Peng ZhangYapeng ZhangGuoyin ZhangJianjun ZhouLei ZhuIlse de LoozePh. AndréC. Darren DowellStewart EyresSam FalleJean-François RobitailleSven van Loo
• Organismes : Max Planck Institute for Radio Astronomy
• Publié dans The Astrophysical Journal le 22/10/2020

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Résumé : Abstract We present 850 μ m dust polarization observations of the massive DR21 filament from the B -fields In STar-forming Region Observations (BISTRO) survey, using the POL-2 polarimeter and the SCUBA-2 camera on the James Clerk Maxwell Telescope. We detect ordered magnetic fields perpendicular to the parsec-scale ridge of the DR21 main filament. In the subfilaments, the magnetic fields are mainly parallel to the filamentary structures and smoothly connect to the magnetic fields of the main filament. We compare the POL-2 and Planck dust polarization observations to study the magnetic field structures of the DR21 filament on 0.1–10 pc scales. The magnetic fields revealed in the Planck data are well-aligned with those of the POL-2 data, indicating a smooth variation of magnetic fields from large to small scales. The plane-of-sky magnetic field strengths derived from angular dispersion functions of dust polarization are 0.6–1.0 mG in the DR21 filament and ∼0.1 mG in the surrounding ambient gas. The mass-to-flux ratios are found to be magnetically supercritical in the filament and slightly subcritical to nearly critical in the ambient gas. The alignment between column density structures and magnetic fields changes from random alignment in the low-density ambient gas probed by Planck to mostly perpendicular in the high-density main filament probed by James Clerk Maxwell Telescope. The magnetic field structures of the DR21 filament are in agreement with MHD simulations of a strongly magnetized medium, suggesting that magnetic fields play an important role in shaping the DR21 main filament and subfilaments.

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• Type de publi. : Article dans une revue
• Date de publi. : 21/12/2022
• Auteurs : Lévi-Dan AzoulayMarine BravettiFleur Cohen-AubartJean-François EmileDanielle SeilheanIsabelle PluFrédéric CharlotteXavier WaintraubFabrice CarratZahir AmouraPhilippe CluzelJulien Haroche
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Hôpital Ambroise Paré [AP-HP] Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut de cardiologie [CHU Pitié-Salpêtrière] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans European Heart Journal le 30/10/2020

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Résumé : Abstract Aims Cardiac involvement of Erdheim–Chester disease (ECD), a rare L group histiocytosis, has been reported to be associated with poor outcomes, but systematic studies are lacking. The present study aimed to investigate the prevalence, clinical features, imaging features, and prognosis of cardiac involvement in ECD in a large series. Methods and results All patients with ECD who underwent cardiac magnetic resonance (CMR) imaging between 2003 and 2019 at a French tertiary center were retrospectively included. Primary outcome was all-cause mortality. Secondary outcomes were pericarditis, cardiac tamponade, conduction disorders, device implantation and coronary artery disease (CAD). A total of 200 patients were included [63 (54–71) years, 30% female, 58% BRAFV600E mutated]. Median follow-up was 5.5 years (3.3–9 years). On CMR, right atrioventricular sulcus infiltration was observed in 37% of patients, and pericardial effusion was seen in 24% of patients. In total, 8 patients (4%) had pericarditis (7 acute, 1 constrictive), 10 patients (5%) had cardiac tamponade, 5 patients (2.5%) had ECD-related high-degree conduction disorders, and 45 patients (23%) had CAD. Overall, cardiac involvement was present in 96 patients (48%) and was associated with BRAFV600E mutation [Odds ratio (OR) = 7.4, 95% confidence interval (CI) (3.5–16.8), P < 0.001] and ECD-related clinical events [OR = 5, 95%CI (1.5–21.2), P = 0.004] but not with lower survival in multivariate analysis [adjusted hazard ratio (HR) = 1.4, 95% CI (0.8–2.5), P = 0.2]. Conclusion Cardiac involvement is present in nearly half of ECD patients and is associated with BRAFV600E mutation and complications (pericarditis, cardiac tamponade, and conduction disorders) but not with lower survival.

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Fichiers liés : Manuscript_ECD_HEART_EHJ_R4_PL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/12/2022
• Auteurs : Marianne GazzanoChristophe ParizotDimitri PsimarasAurore VozyMarine BaronBaptiste AbbarVincent FalletElena LitvinovaAnthony CanellasCristina BirzuValérie PourcherMehdi TouatNicolas WeissSophie DemeretDamien Roos-WeilJean-Philippe SpanoCeleste LebbeJoe‐elie SalemJacques CadranelBaptiste HervierGuy GorochovAmélie Guihot
• Organismes : CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Epidémiologie, Systèmes d'Information, Modélisation CHU Pitié-Salpêtrière [AP-HP] Hopital Saint-Louis [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Tenon [AP-HP] Hopital Saint-Louis [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses
• Publié dans Frontiers in Immunology le 25/10/2020

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Résumé : Immune checkpoint inhibitors (ICI) widely improved the treatment of solid and hematologic malignancies. Yet, a remarkable proportion of patients receiving ICI develop immune related adverse events (irAEs) which are difficult to define as treatment-related. This underlines the need to develop a biomarker to guide irAE diagnosis. We developed a novel flow cytometry assay combining measurement of anti-PD-1 (programmed cell death protein-1) occupancy and evaluation of remaining PD-1 receptor availability with anti-IgG4 PE and anti-PD-1 BV421. We prospectively collected blood and biological fluids samples from patients treated by IgG4 anti-PD-1 therapy (nivolumab or pembrolizumab), with (n=18) or without (n=12) current irAE. We analyzed PD-1+ and IgG4+ staining pattern and MFI values of these parameters on CD4 and CD8 T cells, and IgG4+/PD-1+ MFI ratios are calculated. A higher mean fluorescence intensity IgG4+/PD-1+ ratio was measured on peripheral CD4+ T cells of irAE cases, when compared to controls (p=0.003). ICI-related toxicity is therefore associated with increased therapeutic antibody occupancy of PD-1 receptors on CD4+ T cells. Furthermore, in one case of ICI-related pneumonitis, binding of therapeutic antibody was stronger on lung CD4+ T cell than in blood. In another case of ICI-related encephalitis, the PD-1 receptor occupancy was total on CSF CD4 T cells, but only partial on peripherical CD4 T cells. Our results suggest that flow cytometry monitoring of ICI occupancy can be used in patients treated with monoclonal ICI to guide irAE diagnosis.

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Fichiers liés : Anti-PD-1 immune-related adverse events are associated with high therapeutic antibody fixation on T cells.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2022
• Auteurs : Olivier MousisAlexis BouquetYves LangevinNicolas AndréHélène BoithiasGeorges DurryF. FayePaul HartoghJ. HelbertLuciano IessS KempfAdam MastersF PostbergJean-Baptiste RenardPierre VernazzaA VorburgerP. WurzD. H. AtkinsonS BarabashMatthieu BerthomierJohn Robert BrucatoM CableJohn CarterS CazauxAthena CoustenisGrégoire DangerVéronique DehantTeresa FornaroPhilippe GarnierThomas GautierOlivier GroussinL. Z. HadidJ-C IzeI. KolmasovaJ-P LebretonS Le MaistreEmmanuel LellouchJonathan LunineKathleen MandtZita MartinsDavid MimounQuentin NénonGuillermo M Muñoz CaroPascal RannouH RauerPhilippe Schmitt-KopplinAntoine SchneebergerM. SimonsK StephanT. van HoolstJ. VaverkaM. WieserL Wörner
• Organismes : Laboratoire d'Astrophysique de Marseille Institut universitaire de France Laboratoire d'Astrophysique de Marseille Physique des interactions ioniques et moléculaires Institut d'astrophysique spatiale Institut de recherche en astrophysique et planétologie Airbus Defence and Space [Les Mureaux] Groupe de spectrométrie moléculaire et atmosphérique Airbus Defence and Space [Les Mureaux] Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research DLR Institut für Planetenforschung Dipartimento di Ingegneria Meccanica e Aerospaziale [Roma La Sapienza] Laboratory for Atmospheric and Space Physics [Boulder] Imperial College London Institute of Geological Sciences [Berlin] Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Laboratoire d'Astrophysique de Marseille Physics Institute [Bern] Physics Institute [Bern] Jet Propulsion Laboratory Swedish Institute of Space Physics [Kiruna] Laboratoire de Physique des Plasmas INAF- Osservatorio Astrofisico di Arcetri Jet Propulsion Laboratory Laboratoire d'Astrophysique de Marseille Faculty of Aerospace Engineering [Delft] Leiden Observatory [Leiden] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Physique des interactions ioniques et moléculaires Institut universitaire de France Royal Observatory of Belgium = Observatoire Royal de Belgique INAF- Osservatorio Astrofisico di Arcetri Institut de recherche en astrophysique et planétologie Institut Universitaire de Technologie - Paul Sabatier PLANETO - LATMOS Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Laboratoire d'Astrophysique de Marseille Laboratoire de Physique des Plasmas Laboratoire d'Astrophysique de Marseille Institute of Atmospheric Physics of the Czech Academy of Sciences Faculty of Mathematics and Physics [Praha/Prague] Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Royal Observatory of Belgium = Observatoire Royal de Belgique Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Department of Astronomy [Ithaca] Johns Hopkins University Applied Physics Laboratory [Laurel, MD] Centro de Quimica Estrutural Institut Supérieur de l'Aéronautique et de l'Espace Institut de recherche en astrophysique et planétologie Centro de Astrobiologia [Madrid] Groupe de spectrométrie moléculaire et atmosphérique DLR Institut für Planetenforschung Max-Planck-Institut für Extraterrestrische Physik Laboratoire d'Astrophysique de Marseille Seismological Laboratory, California Institute of Technology DLR Institut für Planetenforschung Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Faculty of Mathematics and Physics [Praha/Prague] Swedish Institute of Space Physics [Kiruna] DLR In­sti­tute of Quan­tum Tech­nolo­gies
• Publié dans The Planetary Science Journal le 01/11/2020

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Résumé : Enceladus, an icy moon of Saturn, possesses an internal water ocean and jets expelling ocean material into space. Cassini investigations indicated that the subsurface ocean could be a habitable environment having a complex interaction with the rocky core. Further investigation of the composition of the plume formed by the jets is necessary to fully understand the ocean, its potential habitability, and what it tells us about Enceladus's origin. Moonraker has been proposed as an ESA M-class mission designed to orbit Saturn and perform multiple flybys of Enceladus, focusing on traversals of the plume. The proposed Moonraker mission consists of an ESA-provided platform with strong heritage from JUICE and Mars Sample Return and carrying a suite of instruments dedicated to plume and surface analysis. The nominal Moonraker mission has a duration of ∼13.5 yr. It includes a 23-flyby segment with 189 days allocated for the science phase and can be expanded with additional segments if resources allow. The mission concept consists of investigating (i) the habitability conditions of present-day Enceladus and its

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Fichiers liés : Mousis_2022_Planet._Sci._J._3_268.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2022
• Auteurs : Sassan S SaatchiWigneron J.-P.Philippe CiaisJérôme ChaveMartin BrandtStephen SitchChao YueAna BastosAndre F FeldmanYuanwei QinWenping YuanDmitry SchepaschenkoLiudmila MukhortovaXiaojun LiXiangzhuo LiuMengjia WangFrédéric FrappartXiangming XiaoJingming ChenMingguo MaJianguang WenXiuzhi ChenHui YangDave van WeesRasmus Fensholt
• Organismes : Southwest University [Chongqing] Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Evolution et Diversité Biologique Department of Geosciences and Natural Resource Management [Copenhagen] College of Life and Environmental Sciences [Exeter] Northwest A & F University Max Planck Institute for Biogeochemistry Institute of Tibetan Plateau Research Chinese Academy of Sciences [Beijing] Department of Microbiology and Plant Biology University of Oklahoma National Sun Yat-sen University Sun Yat-sen University [Guangzhou] V.N. Sukachev Institute of Forest Siberian Federal University V.N. Sukachev Institute of Forest Siberian Branch of the Russian Academy of Sciences Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère University of Oklahoma Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Department of Microbiology and Plant Biology National Sun Yat-sen University University of Toronto Southwest University [Chongqing] State Key Laboratory of Remote Sensing Science Chinese Academy of Sciences [Beijing] Sun Yat-sen University [Guangzhou] Max Planck Institute for Biogeochemistry Vrije Universiteit Brussel [Bruxelles] Department of Geosciences and Natural Resource Management [Copenhagen] IT University of Copenhagen
• Publié dans Nature Geoscience le 26/10/2020

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Résumé : Siberian forests are generally thought to have acted as an important carbon sink over recent decades, but exposure to severe droughts and fire disturbances may have impacted their carbon dynamics. Limited available forest inventories mean the carbon balance remains uncertain. Here we analyse annual live and dead above-ground carbon changes derived from low-frequency passive microwave observations from 2010 to 2019. We find that during this period, the carbon balance of Siberian forests was close to neutral, with the forests acting as a small carbon sink of +0.02+0.03+0.01 PgC yr−1. Carbon storage in dead wood increased, but this was largely offset by a decrease in live biomass. Substantial losses of live above-ground carbon are attributed to fire and drought, such as the widespread fires in northern Siberia in 2012 and extreme drought in eastern Siberia in 2015. These live above-ground carbon losses contrast with ‘greening’ trends seen in leaf area index over the same period, a decoupling explained by faster post-disturbance recovery of leaf area than live above-ground carbon. Our study highlights the vulnerability of large forest carbon stores in Siberia to climate-induced disturbances, challenging the persistence of the carbon sink in this region of the globe.

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Fichiers liés : Siberian%20carbon%20sink%20reduced%20by%20forest%20disturbances_Preprint.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2022
• Auteurs : Jihye HwangJongsoo KimKate PattleC.-W. LeePatrick M KochDoug JohnstoneKohji TomisakaAnthony WhitworthRay FuruyaJi-Hyun KangA.-Ran LyoEun Jung ChungDoris ArzoumanianGeumsook ParkWoojin KwonShinyoung KimMotohide TamuraJungmi KwonArchana SoamIlseung HanThiem HoangKyoung Hee KimTakashi OnakaChakali EswaraiahDaniel R. van RossumHong-Li LiuXindi TangWen Ping ChenMasafumi 雅文 Matsumura 松村Thuong Duc HoangZhiwei ChenValentin Le GouellecFlorian KirchschlagerF PoidevinPierre BastienKeping QiuTetsuo HasegawaShih-Ping LaiDo-Young ByunJungyeon ChoMinho ChoiYoungwoo ChoiYunhee ChoiIl-Gyo JeongMiju KangHyosung KimKee-Tae KimJeong-Eun LeeSang-Sung LeeYong-Hee LeeHyeseung LeeMi-Ryang KimHyunju YooHyeong-Sik YunMike ChenJames Di FrancescoJason FiegeLaura FisselErica FranzmannMartin HoudeKevin LacailleBrenda MatthewsSarah SadavoyGerald Moriarty-SchievenMehrnoosh TahaniTao-Chung ChingY. Sophia DaiYan DuanQi-Lao 琦烙 Gu 顾Chi-Yan LawDalei LiDi LiGuangxing LiHua-Bai LiTie 铁 Liu 刘Xing LuLei QianHongchi WangJintai WuJinjin XieJinghua YuanChuan-Peng ZhangGuoyin ZhangYapeng ZhangJianjun ZhouLei ZhuDavid BerryPer FribergSarah GravesJunhao LiuSteve MairsHarriet ParsonsMark RawlingsYasuo DoiSaeko HayashiCharles L H HullTsuyoshi InoueShu-Ichiro InutsukaKazunari IwasakiAkimasa KataokaKoji S KawabataGwanjeong KimMasato KobayashiTetsuya NagataSandhyarani PanigrahyHiroyuki NakanishiTae-Soo PyoHiro SaitoMasumichi SetaYoshito ShimajiriHiroko ShinnagaYusuke TsukamotoTetsuya ZenkoHuei-Ru Vivien ChenHao-Yuan DuanLapo FanciulloFrancisca KemperChin-Fei LeeSheng-Jun 聖鈞 Lin 林Sheng-Yuan LiuNagayoshi OhashiRamprasad RaoYa-Wen TangJia-Wei WangMeng-Zhe YangHsi-Wei YenTyler BourkeA. ChrysostomouVictor DebattistaD. EdenStewart EyresSam FalleGary FullerTim GledhillJane GreavesMatt GriffinJennifer HatchellJanik KarolyJason KirkVera KönyvesS. LongmoreSven van LooIlse De LoozeNicolas PerettoFelix PriestleyJonathan RawlingsBrendan RetterJohn RicherAndrew RigbyGiorgio SaviniAnna ScaifeSerena VitiP. DiepNguyen Bich NgocLe Ngoc TramPh. AndréSimon CoudéC. Darren DowellRachel FriesenJean-François Robitaille
• Organismes : Korea Astronomy and Space Science Institute Max Planck Institute for Radio Astronomy
• Publié dans The Astrophysical Journal le 22/10/2020

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Résumé : Abstract We present and analyze observations of polarized dust emission at 850 μ m toward the central 1 × 1 pc hub-filament structure of Monoceros R2 (Mon R2). The data are obtained with SCUBA-2/POL-2 on the James Clerk Maxwell Telescope (JCMT) as part of the B-fields in Star-forming Region Observations survey. The orientations of the magnetic field follow the spiral structure of Mon R2, which are well described by an axisymmetric magnetic field model. We estimate the turbulent component of the magnetic field using the angle difference between our observations and the best-fit model of the underlying large-scale mean magnetic field. This estimate is used to calculate the magnetic field strength using the Davis–Chandrasekhar–Fermi method, for which we also obtain the distribution of volume density and velocity dispersion using a column density map derived from Herschel data and the C 18 O ( J = 3 − 2) data taken with HARP on the JCMT, respectively. We make maps of magnetic field strengths and mass-to-flux ratios, finding that magnetic field strengths vary from 0.02 to 3.64 mG with a mean value of 1.0 ± 0.06 mG, and the mean critical mass-to-flux ratio is 0.47 ± 0.02. Additionally, the mean Alfvén Mach number is 0.35 ± 0.01. This suggests that, in Mon R2, the magnetic fields provide resistance against large-scale gravitational collapse, and the magnetic pressure exceeds the turbulent pressure. We also investigate the properties of each filament in Mon R2. Most of the filaments are aligned along the magnetic field direction and are magnetically subcritical.

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