Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Jean-Michel TorrentiOuali AmiriLaury Barnes-DavinFrédéric BougrainSandrine BraymandBogdan CazacliuJohan ColinAmaury CudevillePatrick DanglaAssia DjerbiMathilde DoutreleauAdélaïde FerailleMarielle GueguenXavier GuillotYunlu HouLaurent IzoretYvan-Pierre JacobJena JeongJean David Lau Hiu HoongPierre-Yves MahieuxJonathan Mai-NhuHeriberto MartinezVincent MeyerVincent MorinThomas PerninJean-Marc PotierLaurent PoulizacPatrick RougeauMyriam SaadéLucie SchmittThierry SedranMarie SerengAnthony SoiveGlaydson Symoes dos ReysPhilippe TurcryVincent Le Cam
• Organismes : Département Matériaux et Structures Institut de Recherche en Génie Civil et Mécanique Centre Scientifique et Technique du Bâtiment Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Granulats et Procédés d'Elaboration des Matériaux Laboratoire Navier UMR Matériaux pour une construction durable Centre Scientifique et Technique du Bâtiment Comportement Physico-chimique et Durabilité des Matériaux Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Comportement Physico-chimique et Durabilité des Matériaux Matériaux pour Infrastructure de Transport Formulation, Microstructure, Modélisation et Durabilité des Matériaux de Construction Granulats et Procédés d'Elaboration des Matériaux Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 Statistical Inference for Structural Health Monitoring Structure et Instrumentation Intégrée
• Publié dans Case Studies in Construction Materials le 30/11/2015

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Fichiers liés : The FastCarb project.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Catherine SchrammCamille CharbonnierAline ZaréaMorgane LacourDavid WallonDaniela AndriutaPierre AnthonySophie AuriacombeAnna-Chloé BalageasGuillaume BallanMélanie BarbayEmilie BeaufilsYannick BéjotSerge BelliardMarie BenaiteauKarim BennysFrédéric BlancStéphanie BomboisClaire Boutoleau-BretonnièrePierre BrangerJasmine CarlierLeslie Cartz-PiverPascaline CassagnaudGiovanni CastelnovoChristine ChampionAnnabelle ChaussenotMathieu CeccaldiValérie ChauviréYaohua ChenJulien CogezEmmanuel CognatFabienne Contegal-CallierLea CorneillePhilippe CouratierHélène CourtemancheBenjamin CretinCharlotte CrinquetteBernard CroisilleBenjamin DauriatSophie DautricourtVincent de la SayetteAstrid de LiègeMarie de VerdalDidier DeffondEmmanuelle GéninBenoit DelpontFlorence DemurgerVincent DeramecourtCéline DerollezMira DidicGiulia DiemertElsa DionetPhilippe DiraisonAude DoanMartine Doco-FenzyBoris DufournetJulien DumurgierHélène DurandAnaïs DutrayFrédérique Etcharry-BouyxMaïté FormaglioAudrey GabelleAnne Gainche-SalmonJean-Claude GetenetEmmanuelle GinglingerOlivier GodefroyMathilde GraberChloé GregoireStephan GrimaldiJulien GueniatClaude GueriotSophie HaffenLorraine HamelinDidier HannequinCezara HantaClémence HardyGeoffroy HautecloqueCamille HeitzClaire HourregueThérèse JonveauxSnejana JuriciCatia KhoumriLejla KoricPierre Krolak-SalmonPierre LabaugeMorgane LacourJulien LagardeHélène-Marie LanoiseléeBrice LaurensIsabelle Le BerGwenaël Le GuyaderAmélie LeblancThibaud LebouvierAnaïs LippiMarie-Anne MackowiakEloi MagninCecilia MarelliOlivier MartinaudAurélien MaureilleEmilie Milongo-RigalSophie MohrHélène MollionOlivier MoreaudAlexandre MorinGaël NicolasJulia NivelleCamille NoirayElisabeth Ollagnon-RomanClaire PaquetJérémie ParienteFlorence PasquierAlexandre PerronNathalie PhilippiVirginie PichonVincent PlancheCéline PoirsierMarie RafiqPauline Rod-OlivieriAdeline Rollin-SillaireCarole Roué-JagotDario SaracinoMarie SarazinMathilde SauvéeFrançois SellalLila Sirven VillarosChristel Thauvin-RobinetCamille TisserandChristophe TomasinoCédric TurpinatLaurène van DammeOlivier VercruysseAlice VoillyNathalie WagemannDavid WallonAline ZareaAnne BolandJean-François DeleuzeRobert OlasoShahzad AhmadPhilippe AmouyelClaudine BerrAnne BolandPaola BossuFemke BouwmanJose BrasDominique CampionCamille CharbonnierJordi ClarimonAntonio DanieleJean-François DartiguesStéphanie DebetteJean-François DeleuzeNicola DenningOriol Dols-IcardoNick FoxDaniela GalimbertiHans GilleBenjamin Grenier-BoleyDetelina GrozevaRita GuerreiroJohn HardyClive HolmesHenne HolstegeMarc HulsmanHolger HummerichM. Arfan IkramM. Kamran IkramIris JansenAmit KawaliaRobert KraaijJean-Charles LambertMarc LathropAfina LemstraAlberto LleoLauren LuckcuckMarcel MannensRachel MarshallCarlo MasulloSimon MeadPatrizia MecocciAlun MeggyMerel MolKevin MorganBenedetta NacmiasGaël NicolasPenny NorsworthyFlorence PasquierPau PastorOlivier QuenezAlfredo RamirezRachel RaybouldRichard RedonMarcel ReindersAnne-Claire RichardSteffi Riedel-HellerFernando RivadeneiraStéphane RousseauNatalie RyanSalha SaadPascual Sanchez-JuanPhilip ScheltensJonathan SchottDavide SeripaDaoud SieRebecca SimsErik SistermansSandro SorbiResie van SpaendonkGianfranco SpalletaNicćolo TesiBetty TijmsAndré UitterlindenWiesje van der FlierSven van der LeeCornelia van DuijnJeroen van RooijJohn van SwietenPieter de VisserMichael WagnerDavid WallonJulie WilliamsAline ZareaFlora AlarconDominique CampionG. NuelGaël Nicolas
• Organismes : Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques CHU Rouen Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques Service de neurologie [Rouen] UNIROUEN - UFR Santé Service de neurologie [Rouen] CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Centre national de référence pour les malades Alzheimer jeunes Institut des Maladies Neurodégénératives [Bordeaux] CHU Trousseau [Tours] Centre Hospitalier de la Côte Basque CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Centre national de référence pour les malades Alzheimer jeunes CHU Trousseau [Tours] Université de Bourgogne Université Lille Nord (France) AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité Santé publique France - French National Public Health Agency [Saint-Maurice, France] Obstetrical, Perinatal and Pediatric Epidemiology | Épidémiologie Obstétricale, Périnatale et Pédiatrique Université Paris Descartes, Sorbonne Paris Cité Service de Neurologie [CHU Rennes] Département Neurologie [CHU Toulouse] Département de neurologie [Montpellier] Centre Hospitalier Universitaire [Strasbourg] Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie Centre Mémoire Ressources et Recherche [Strasbourg] CHU Pitié-Salpêtrière [AP-HP] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital Hôpital Côte de Nacre [CHU Caen] UNIROUEN - UFR Santé Epidémiologie des Maladies Chroniques en zone tropicale Génétique, génomique fonctionnelle et biotechnologies (UMR 1078) CHU Amiens-Picardie Laboratoire de Neurosciences Fonctionnelles et Pathologies - UR UPJV 4559 Centre national de référence pour les malades Alzheimer jeunes Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Centre National de Recherche en Génomique Humaine Mathématiques Appliquées Paris 5
• Publié dans Genome Medicine le 24/10/2020

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Résumé : Abstract Background Alzheimer disease (AD) is a common complex disorder with a high genetic component. Loss-of-function (LoF) SORL1 variants are one of the strongest AD genetic risk factors. Estimating their age-related penetrance is essential before putative use for genetic counseling or preventive trials. However, relative rarity and co-occurrence with the main AD risk factor, APOE -ε4, make such estimations difficult. Methods We proposed to estimate the age-related penetrance of SORL1 -LoF variants through a survival framework by estimating the conditional instantaneous risk combining (i) a baseline for non-carriers of SORL1- LoF variants, stratified by APOE-ε4 , derived from the Rotterdam study ( N = 12,255), and (ii) an age-dependent proportional hazard effect for SORL1- LoF variants estimated from 27 extended pedigrees (including 307 relatives ≥ 40 years old, 45 of them having genotyping information) recruited from the French reference center for young Alzheimer patients. We embedded this model into an expectation-maximization algorithm to accommodate for missing genotypes. To correct for ascertainment bias, proband phenotypes were omitted. Then, we assessed if our penetrance curves were concordant with age distributions of APOE -ε4-stratified SORL1- LoF variant carriers detected among sequencing data of 13,007 cases and 10,182 controls from European and American case-control study consortia. Results SORL1- LoF variants penetrance curves reached 100% (95% confidence interval [99–100%]) by age 70 among APOE -ε4ε4 carriers only, compared with 56% [40–72%] and 37% [26–51%] in ε4 heterozygous carriers and ε4 non-carriers, respectively. These estimates were fully consistent with observed age distributions of SORL1- LoF variant carriers in case-control study data. Conclusions We conclude that SORL1- LoF variants should be interpreted in light of APOE genotypes for future clinical applications.

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Fichiers liés : Article-Schramm-Genome-Medicine-2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Sara ThietartAriane BoumendilDominique PateronBertrand GuidetH. ValletBertrand GuidetDominique PateronErwan DebucYouri YordanovAriane BoumendilCaroline ThomasDidier DreyfussJean-Damien RicardPatrick BrunChristophe LeroyYves CohenFrédéric AdnetMaguy WoimantJean-Paul MiraBenoît DoumencKhalil TkuThomas SimilowskiBruno RiouPierre HausfaterSamuel DelermeJean-Pierre QuenotDidier HonnartJean-François TimsitPierrick GuérinFrançoise CarpentierMaxime MaignanFoued MakhlouJean-François PousselYohann PicardFrançois BraunPauline TrognonFrançois FourrierPatrick GoldsteinMarie GirotPierre GosselinFrancesco SantoliPierre CharestanClaire PolyHervé MentecCatherine Le GallKarima SahraouiChristophe BaillardNicolas JavaudBenoît MissetMaité Garrouste-OrgeasOlivier GanansiaFrançois-Xavier RooryckJean Luc AimAbudlrazak El RifaiJean ReignierLaurent Martin-LefevrePhilippe FradinClaire MauriatEmelyne CwicklinskiMichel SlamaHervé DupontChristine AmmiratiJustine GallouMuriel FartoukhMichel DjibrePatrik RayEdwin RouffBertrand SouweineAli Ait HssainJeannot SchmidtDaniel PicFarès MoustafaAlain MercatNicolas LerollePierre-Marie RoyFrédéric BaudPatrick PlaisanceSophie MontagnonBertrand GalichonMichel WolffBruno MourvillierEnrique CasalinoChristophe ChoquetJulien BernardGaëlle JuillienJean-Yves FagonEmmanuel GuerotPhilippe JuvinAnabela PatzakBruno VerdièreVincent IoosMarie-Clément KoukaAudrey BerthoumieuChristian RichardRaphael MauriceSophie SarnelStéphane DiezAntoine Vieillard BaronSébastien BeauneJulie GrenetSylvie AzeradGuillaume LeblancTabassome Simon
• Organismes : CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique Centre d'Immunologie et des Maladies Infectieuses CHU Saint-Antoine [AP-HP] CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Assistance publique - Hôpitaux de Paris (AP-HP) Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] Musée du Louvre Hôpital Louis Mourier - AP-HP [Colombes] CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Hôpital d'instruction des Armées Percy Assistance publique - Hôpitaux de Paris (AP-HP) Hôpital Avicenne [AP-HP] Hôpital Avicenne [AP-HP] SAMU 93 [Bobigny] Marqueurs cardiovasculaires en situation de stress Hôpital Avicenne [AP-HP] Institut Cochin Hôpital Cochin [AP-HP] AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris] Neurophysiologie Respiratoire Expérimentale et Clinique CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe de recherche clinique Biomarqueurs d’urgence et de réanimation Centre d'Immunologie et des Maladies Infectieuses CHU Dijon Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques Département de Médecine d'Urgence - Centre Régional Universitaire des Urgences (CRUU) (CHU de Dijon) AP-HP - Hôpital Bichat - Claude Bernard [Paris] Infection, Anti-microbiens, Modélisation, Evolution Service d'accueil des urgences médicales Université Grenoble Alpes Service de Soins Intensifs [CHR Metz-Thionville] Centre hospitalier régional de Metz-Thionville Université Henri Poincaré - Nancy 1 Hôpital Roger Salengro [Lille] Samu du Nord–pôle de l’urgence [Lille] Department of Emergency [Lille] Hôpital Robert Ballanger [Aulnay-sous-Bois] Hôpital Robert Ballanger [Aulnay-sous-Bois] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Centre hospitalier Victor Dupouy [Centre hospitalier d'Argenteuil] Hôpital Cochin [AP-HP] Hôpital Louis Mourier - AP-HP [Colombes] Centre de référence national des angiœdèmes Université Paris Cité Centre Hospitalier Universitaire de Liège Institut hospitalier Franco-Britannique [Levallois-Perret] Centre hospitalier Saint-Joseph [Paris] Centre Hospitalier Universitaire de Nantes = Nantes University Hospital
• Publié dans Annals of Intensive Care le 23/10/2020

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Résumé : Abstract Background Little is known about the impact of hospital trajectory on survival and functional decline of older critically ill patients. We evaluate 6-month outcomes after admission to: intensive care units (ICU), intermediate care units (IMCU) or acute medical wards (AMW). Methods Data from the randomised prospective multicentre clinical trial ICE-CUB2 was secondarily analysed. Inclusion criteria were: presenting at emergency departments in critical condition; age ≥ 75 years; activity of daily living (ADL) ≥ 4; preserved nutritional status; and no active cancer. A Cox model was fitted to compare survival according to admission destination adjusting for patient characteristics. Sensitivity analysis using multiple imputation for missing data and propensity score matching were performed. Results Among 3036 patients, 1675 (55%) were women; median age was 85 [81–99] years; simplified acute physiology score (SAPS-3) 62 [55–69]; 1448 (47%) were hospitalised in an ICU, 504 in IMCU (17%), and 1084 (36%) in AMW. Six-month mortality was 629 (44%), 155 (31%) and 489 (45%) after admission in an ICU, IMCU and AMW ( p < 0.001), respectively. In multivariate analysis, AMW admission was associated with worse 6-month survival (HR 1.31, 95% CI 1.04–1.63) in comparison with IMCU admission, after adjusting for age, gender, comorbidities, ADL, SAPS-3 and diagnosis. Survival was not significantly different between patients admitted in an ICU and an IMCU (HR 1.17, 95% CI 0.95–1.46). Sensitivity analysis using multiple imputation for missing data and propensity score matching found similar results. Hospital destination was not significantly associated with the composite criterion loss of 1-point ADL or mortality. Physical and mental components of the 12-Item Short-Form Health Survey were significantly lower in the acute medical ward group (34.3 [27.5–41.7], p = 0.037 and 44.3 [38.6–48.6], p = 0.028, respectively) than in the ICU group (34.7 [28.4–45.3] and 45.5 [40.0–50.0], respectively) and IMCU group (35.7 [29.7–43.8] and 44.5 [39.7–48.4], respectively). Conclusions Admission in an AMW was associated with worse 6-month survival in older critically ill patients in comparison with IMCU admission, with no difference of survival between ICU and IMCU admission. There were no clinically relevant differences in quality of life in each group. These results should be confirmed in specific studies and raise the question of dedicated geriatric IMCUs.

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Fichiers liés : s13613-022-01042-4.pdf

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• Type de publi. : Rapport
• Date de publi. : 01/12/2022
• Auteurs : Carole CarantaMathilde CausseFabien NoguéAnnabelle DéjardinEmilie GentiliniPhilippe DebaekeLaurent HazardSophie Le PerchecStéphane LemariéGuy RichardPeter RogowskyMarie-Violaine Tatry
• Organismes : Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement Génétique et Amélioration des Fruits et Légumes Institut Jean-Pierre Bourgin - Sciences du végétal Biologie intégrée pour la valorisation de la diversité des Arbres et de la Forêt Direction pour la Science Ouverte AGroécologie, Innovations, teRritoires AGroécologie, Innovations, teRritoires Direction pour la Science Ouverte Laboratoire d'Economie Appliquée de Grenoble Direction de l'Expertise scientifique collective, de la Prospective et des Etudes Reproduction et développement des plantes Direction pour la Science Ouverte

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Fichiers liés : ETUDE EDITION du GENOME et AGROECOLOGIE_VF.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Ali AbbasSheryl Ann AbdukahilNurul Najmee AbdulkadirRyuzo AbeLaurent AbelLara AbsilKamal Abu JabalHiba Abu ZayyadSubhash AcharyaAndrew AckerShingo AdachiElisabeth AdamEnrico AdrianoDiana AdriãoSaleh Al AgeelShakeel AhmedMarina AielloKate AinscoughEka AirlanggaTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimTala Al-DabbousAbdulrahman Al-FaresRazi AlalqamAngela AlbertiSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreHuda AlfoudriAdam AliImran AliNaseem Ali ShahNaseem Ali SheikhKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouAneela AltafJoão AlvesJoão Melo AlvesRita AlvesMaria AmaralNur AmiraHeidi AmmerlaanPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartSivanesen AnthonidassMassimo AntonelliCarlos Alexandre Antunes de BritoKazi Rubayet AnwarArdiyan ApriyanaYaseen ArabiIrene AragaoFrancisco ArancibiaCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayAna ArocaLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalMotohiro AsakiAngel AsensioElizabeth AshleyMuhammad AshrafNamra AsifMohammad AsimJean Baptiste AssieAmirul AsyrafAnika AtiqueA. AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetEyvind AxelsenLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrRoar Bævre-JensenNadia BaigJ. Kenneth BaillieJ Kevin BairdErica BakAgamemnon BakakosNazreen Abu BakarAndriy BalMohanaprasanth BalakrishnanValeria BalanFirouzé Bani-SadrRenata BarbalhoNicholas Yuri BarbosaWendy BarclaySaef Umar BarnettMichaela BarnikelHelena BarrasaAudrey BarreletCleide BarrigotoMarie BartoliCheryl BartoneJoaquín BaruchMustehan BashirRomain BasmaciMuhammad Fadhli Hassin BasriDenise BattagliniJules BauerDiego Fernando Bautista RinconDenisse Bazan DowAbigail BeaneAlexandra BedossaKer Hong BeeHusna BegumSylvie BehilillKarine BeirutiAlbertus BeishuizenAleksandr BeljantsevDavid BellemareAnna BeltrameBeatriz Amorim BeltrãoMarine BeluzeNicolas BenechLionel Eric BenjimanDehbia BenkerrouSuzanne BennettLuís BentoJan-Erik BerdalDelphine BergeaudHazel BerginJosé Luis Bernal SobrinoGiulia BertoliLorenzo BertolinoSimon BessisAdam BetzSybille BevilcaquaKarine BezulierAmar BhattKrishna BhavsarIsabella BianchiClaudia BiancoFarah Nadiah BidinMoirangthem Bikram SinghFelwa Bin HumaidMohd Nazlin Bin KamarudinFrançois BissuelPatrick BistonLaurent BitkerJonathan BittonPablo Blanco-SchweizerCatherine BlierFrank BloosMathieu BlotLucille BlumbergFilomena BocciaLaetitia BodenesAlice BogaartsDebby BogaertAnne-Hélène BoivinPierre-Adrien BolzeFrançois BompartPatrizia BonelliAurelius BonfasiusDiogo BorgesRaphaël BorieHans Martin BosseElisabeth Botelho-NeversLila BouadmaOlivier BouchaudSabelline BouchezDounia BouhmaniDamien BouhourKevin BouillerLaurence BouilletCamile BouisseThipsavanh BounphiengsyLatsaniphone BountthasavongAnne-Sophie BoureauJohn BourkeMaude BouscambertAurore BousquetJason BouziotisBianca BoxmaMarielle Boyer-BesseyreMaria BoylanFernando Augusto BozzaAxelle BraconnierCynthia BragaTimo BrandenburgerFilipa Brás MonteiroLuca BrazziDorothy BreenPatrick BreenKathy BrickellAlex BrowneShaunagh BrowneNicolas BrozziSonja Hjellegjerde BrunvollMarjolein Brusse-KeizerNina BuchteleChristian BuesaquilloPolina BugaevaMarielle BuissonDanilo BuonsensoErlina BurhanAidan BurrellIngrid BustosDenis ButnaruAndré CabieSusana CabralEder CaceresCyril CadozMia CallahanKate CalligyJose Andres CalvacheCaterina CaminitiJoão CamõesValentine CampanaPaul CampbellJosie CampisiCecilia CanepaMireia CanteroPauline Caraux-PazSheila CárcelChiara Simona CardellinoFilipa CardosoFilipe CardosoNelson CardosoSofia CardosoSimone CarelliFrancesca CarlacciNicolas CarlierThierry CarmoiGayle CarneyInês CarquejaMarie-Christine CarretFrançois Martin CarrierIda CarrollGail CarsonLeonor CarvalhoMaire-Laure CasanovaMariana CascãoSiobhan CaseyJosé CasimiroBailey CassandraSilvia CastañedaNidyanara CastanheiraGuylaine Castor-AlexandreHenry CastrillónIvo CastroAna CatarinoFrançois-Xavier CatherinePaolo CattaneoRoberta CavalinGiulio Giovanni CavalliAlexandros CavayasAdrian CeccatoMinerva Cervantes-GonzalezAnissa ChairCatherine ChakveatzeAdrienne ChanMeera ChandChristelle Chantalat AugerJean-Marc ChapplainJulie ChasAllegra ChatterjeeMobin ChaudryJonathan Samuel Chávez IñiguezAnjellica ChenYih-Sharng ChenMatthew Pellan ChengAntoine CheretAlfredo Antonio ChettaThibault ChiarabiniJulian ChicaSuresh Kumar ChidambaramLeong Chin ThoCatherine ChirouzeDavide ChiumelloHwa Jin ChoSung-Min ChoBernard CholleyDanoy ChommanamMarie-Charlotte ChopinTing Soo ChowYock Ping ChowNathaniel ChristyHiu Jian ChuaJonathan ChuaJose Pedro CidadeJosé Miguel Cisneros HerrerosBarbara Wanjiru CitarellaAnna CiulloEmma ClarkeJennifer ClarkeRolando Claure-Del GranadoSara ClohiseyPerren CobbCassidy CodanCaitriona CodyAlexandra CoelhoMegan ColesGwenhaël ColinMichael CollinsSebastiano Maria ColomboPamela CombsMarie ConnorAnne ConradSofía ContrerasElaine ConwayGraham CookeMary CoplandHugues CordelAmanda CorleySabine CornelisAlexander Daniel CornetArianne Joy CorpuzAndrea CortegianiGrégory CorvaisierEmma CostiganCamille CouffignalSandrine Couffin-CadierguesRoxane CourtoisStéphanie CousseRachel CreganCharles Crepy D’orleansSabine CroonenGloria CrowlJonathan CrumpClaudina CruzJuan Luis Cruz BermJaime Cruz RojoMarc CseteAlberto CucinoAilbhe CullenMatthew CummingsGer CurleyGerard CurleyElodie CurlierColleen CurranPaula CustodioFederico D’amicoFrédérick D’aragonEric D’ortenzioAna da Silva FilipeCharlene da SilveiraAl-Awwab DabalizAndrew DagensJohn Arne DahlDarren DahlyHeidi DaltonJo DaltonSeamus DalyNick DanemanCorinne DanielEmmanuelle DankwaJorge DantasMark de BoerGillian de LoughryDiego de MendozaEtienne de MontmollinRafael Freitas de Oliveira FrançaAna Isabel de Pinho OliveiraRosanna de RosaCristina de RoseThushan de SilvaPeter de VriesJillian DeaconDavid DeanAlexa DebardBianca DebenedictisMarie-Pierre DebrayNathalie DecastroWilliam DechertLauren DeconninckRomain DecoursEve DefousIsabelle DelacroixEric DelaveuveKaren DelavigneNathalie DelfosIonna DeligiannisAndrea Dell’amoreChristelle DelmasPierre DelobelCorine DelsingElisa DemonchyEmmanuelle DenisDominique DeplanquePieter DepuydtMehul DesaiDiane DescampsMathilde DesvalléesSanti DewayantiPathik DhangerAlpha DialloSylvain DiamantisAndré DiasAndrea DiasJuan Jose 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• Organismes : Imagine - Institut des maladies génétiques (IHU) Centre Hospitalier Universitaire de Toulouse Institut Universitaire du Cancer de Toulouse - Oncopole Service Maladies infectieuses et tropicales [CHU Toulouse] Service Pneumologie-Allergologie [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Pôle Clinique des Voies respiratoires [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] ARN régulateurs bactériens et médecine Service Maladies infectieuses et tropicales [CHU Toulouse] Centre Hospitalier Universitaire de Toulouse Centre Hospitalier Universitaire de Toulouse Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses Centre National de Référence des virus des infections respiratoires (dont la grippe) - National Reference Center Virus Influenzae [Paris] Universidad de La Sabana [Chía, Cundinamarca, Colombia] = La Sabana University [Chía, Cundinamarca, Colombia] The University of Queensland University of British Columbia [Canada] Universidad de La Sabana [Chía, Cundinamarca, Colombia] = La Sabana University [Chía, Cundinamarca, Colombia] University of Oxford
• Publié dans Scientific Data le 29/10/2020

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Résumé : The International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 dataset is one of the largest international databases of prospectively collected clinical data on people hospitalized with COVID-19. This dataset was compiled during the COVID-19 pandemic by a network of hospitals that collect data using the ISARIC-World Health Organization Clinical Characterization Protocol and data tools. The database includes data from more than 705,000 patients, collected in more than 60 countries and 1,500 centres worldwide. Patient data are available from acute hospital admissions with COVID-19 and outpatient follow-ups. The data include signs and symptoms, pre-existing comorbidities, vital signs, chronic and acute treatments, complications, dates of hospitalization and discharge, mortality, viral strains, vaccination status, and other data. Here, we present the dataset characteristics, explain its architecture and how to gain access, and provide tools to facilitate its use.

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Fichiers liés : s41597-022-01534-9.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Nadim CassirFlorian CardonaHervé Tissot-DupontChristiane BruelBarbara DoudierSalima LahouelKarim BendamardjiCéline BoschiSarah AherfiSophie EdouardJean-Christophe LagierPhilippe ColsonPhilippe GautretPierre-Edouard FournierPhilippe ParolaPhilippe BrouquiBernard La-ScolaMatthieu Million
• Organismes : Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Agence Régionale de la Santé Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection
• Publié dans Emerging Infectious Diseases le 27/10/2020

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Résumé : We enrolled 136 patients with laboratory-confirmed monkeypox during June 4–August 31, 2022, at the University Hospital Institute Méditerranée Infection in Marseille, France. The median patient age was 36 years (interquartile range 31–42 years). Of 136 patients, 125 (92%) were men who have sex with men, 15 (11%) reported previous smallpox vaccinations, and 21 (15.5%) were HIV-positive. The most frequent lesion locations were the genitals (68 patients, 53%), perianal region (65 patients, 49%), and oral/perioral area (22 patients, 17%). Lesion locations largely corresponded with the route of contamination. Most (68%) patients had isolated anal, genital, or oral lesions when they were first seen, including 56 (61%) who had >1 positive site without a visible lesion. Concurrent sexually transmitted infections were diagnosed in 19 (15%) patients, and 7 patients (5%) were asymptomatic. We recommend vaccination campaigns, intensified testing for sexually transmitted infections, and increased contact tracing to control the ongoing monkeypox outbreak.

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Fichiers liés : 22-1440.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Fernando ZampieriBruno da CostaSuvi VaaraFrançois LamontagneBram RochwergAlistair NicholShay McguinnessDanny McauleyMarlies OstermannRon WaldSean BagshawSean BagshawRon WaldNeill AdhikariRinaldo BellomoDidier DreyfussBin DuMartin GallagherStéphane GaudryFrançois LamontagneMichael JoannidisKathleen LiuDaniel McauleyShay McguinnessAlistair NicholMarlies OstermannPaul PalevskyHaibo QiuVille PettiläAntoine SchneiderOrla SmithSuvi VaaraMatthew WeirRinaldo BellomoGlenn EastwoodLeah PeckHelen YoungPeter KrugerGordon LaurieEmma SaylorJason MeyerEllen VenzKrista WetzigCraig FrenchForbes McgainJohn MulderGerard FennessySathyajith KoottayiSamantha BatesMiriam TownsRebecca MorganAnna TippettAndrew UdyChris MasonElisa LicariDashiell GantnerJason McclureAlistair NicholPhoebe MccrackenJasmin BoardEmma MartinShirley VallanceMeredith YoungChelsey VladicSteve McgloughlinDavid GattasHeidi BuhrJennifer ColesDebra HutchJames WunLouise ColeChristina WhiteheadJulie LowreyKristy MastersRebecca GreshamVictoria CampbellDavid GutierrezJane BrailsfordLoretta ForbesLauren MurrayTeena MaguireMartina NichonghaileNeil OrfordAllison BoneTania ElderkinTania SalernoTim ChimundaJason FletcherEmma BroadfieldSanjay PorwalCameron KnottCatherine BoschertJulie SmithAngus RichardsonDianne HillGraeme DukePeter OziemskiSantiago CegarraPeter ChanDeborah WelshStephanie HunterOwen RoodenburgJohn DyettNicos KokotsisMax MoserYang YangLaven PadayacheeJoseph VetroHimangsu GangopadhyayMelissa KaufmanAngaj GhoshSimone SaidAlpesh PatelShailesh BihariElisha MathesonXia JinTapaswi ShresthaKate SchwartzMartin GallagherRosalba CrossWinston CheungHelen WongMark KolAsim ShahAmanda WangZoltan EndreCelia BradfordPierre JaninSimon FinferNaomi DielJonathan GatwardNaomi HammondAnthony DelaneyFrances BassElizabeth YaradHergen BuscherClaire ReynoldsNerilee BakerMichael JoannidisRomuald BellmannAndreas PeerJulia HasslacherPaul KoglbergerSebastian KleinKlemens ZotterAnna BrandtnerArmin FinkenstedtAdelheid DitlbacherFrank HartigDietmar FriesMirjam BachlerBettina SchenkMartin WagnerPhilipp EllerThomas StaudingerEsther TillerPeter SchellongowskiAndja BojicEric HosteStephanie BrackeLuc de CropDaisy VermeirenFernando ThomeBianca ChiellaLucia FendtVeronica AntunesJean-Philippe LafranceFrançois LamontagneFrédérick D’aragonCharles St-ArnaudMichael MayetteÉlaine CarbonnaeuJoannie MarchandMarie-Hélène MasseMarilène LadouceurAlexis TurgeonFrançois LauzierDavid BellemareCharles Langis FrancoeurGuillaume LeblancGabrielle GuilbaultStéphanie GrenierEve CloutierAnnick BoivinCharles Delisle-ThibaultPanagiota GiannakourosOlivier CosterousseJean-François CailhierFrançois-Martin CarrierAli GhamraouiMartine LebrasseurFatna BenettaibMaya SalaméDounia BoumahniYing Tung SiaJean-François NaudIsabelle RoyHenry StelfoxStacey RuddellBraden MannsShelley DugganDominic CarneyJennifer BarchardRichard WhitlockEmilie Belley-CoteNevena SavijaAlexandra SabevTroy CampbellThais CrearyKelson DevereauxShira BrodutchClaudio RigattoBojan PaunovicOwen MooneyAnna GlybinaOksana HarasemiwMichelle Di NellaJohn HarmonNavdeep MehtaLouis LakatosNicole HaslamFrancois LelloucheMathieu SimonYing TungPatricia LizottePierre-Alexandre BourchardBram RochwergTim KarachiTina MillenJohn MuscedereDavid MasloveJ. Gordon BoydStephanie SibleyJohn DroverMiranda HuntIlinca GeorgescuRandy WaxIlan LengaKavita SridharAndrew SteeleKelly FuscoTaneera GhateMichael TolibasHolly RobinsonMatthew WeirRavi TanejaIan BallAmit GargEileen CampbellAthena OvsenekSean BagshawSean van DiepenNadia BaigSheldon MagderHan YaoAhsan AlamJosie CampisiErika MacintyreElla RokoshKimberly ScherrStephen LapinskySangeeta MehtaSumesh ShahDaniel NivenHenry StelfoxStacey RuddellMichael RussellKym JimGillian BrownKerry OxtobyAdam HallLuc BenoitColleen SokolowskiBhanu PrasadJag RaoShelley GiebelDemetrios KutsogiannisPatricia ThompsonTayne ThompsonRobert CironeKanthi KavikondalaMark SothFrance ClarkeAlyson TakaokaRon WaldDavid MazerKaren BurnsJan FriedrichDavid KleinGyan SandhuMarlene SantosImrana KhalidJennifer HodderPeter DodekNajib AyasVictoria AlcuazGabriel SuenOleksa RewaGurmeet SinghSean NorrisNeil GibsonCastro AriasAysha ShamiCeline PelletierNeill AdhikariAlireza ZahiriehAndre AmaralNicole MarinoffNavjot KaurAdic PerezJane WangGregory HaljanChristopher CondinLauralyn McintyreBrigette GomesRebecca PorteousIrene WatpoolSwapnil HiremathEdward ClarkMargaret HerridgeFelicity BackhouseM. Elizabeth WilcoxKarolina WalczakVincent KiAsheer SharmanMartin RomanoSean BagshawR. Noel GibneyAdam RomanovskyOleksa RewaLorena MccoshenNadia BaigGordon WoodDaniel OvakimFiona AuldGayle CarneyMeili DuanXiaojun JiDongchen GuoZhili QiJin LinMeng ZhangLei DongJingfeng LiuPei LiuDeyuan ZhiGuoqiang BaiYu QiuZiqi YangJing BaiZhuang LiuHaizhou ZhuangHaiman WangJian LiMengya ZhaoXiao ZhouXianqing ShiBaning YeManli LiuJing WuYongjian FuDali LongYu PanJinlong WangHuaxian MeiSongsong ZhangMingxiang WenEnyu YangSijie MuJianquan LiTingting HuBingyu QinMin LiCunzhen WangXin DongKaiwu WangHaibo WangJianxu YangBin DuChuanyao WangDongxin WangNan LiZhui YuSong XuLan YaoGuo HouZhou LiuLiping LuYingtao LianChunting WangJichen ZhangRuiqi DingGuoqing QiQizhi WangPeng WangZhaoli MengMan ChenXiaobo HuXiandi HeShibing ZhaoLele HangRui LiSuhui QinKun LuShijuan DunCheng LiuQi ZhouZhenzhen ChenJing MeiMinwei ZhangHao XuJincan LinQindong ShiLijuan FuQinjing ZengHongye MaJinqi YanLan GaoHongjuan LiuLei ZhangHao LiXiaona HeJingqun FanLitao GuoYu LiuXue WangJingjing SunZhongmin LiuJuan YangLili DingLulu ShengXingang LiuJie YanQuihui WangYifeng WangDan ZhaoShuangping ZhaoChenghuan HuJing LiFuxing DengHaibo QuiYi YangMin MoChun PanChangde WuYingzi HuangLili HuangAiran LiuVille PettiläSuvi VaaraAnna-Maija KorhonenSanna TörnblomSari SutinenLeena PettiläJonna HeinonenEliria LappiTaria SuhonenSari KarlssonSanna HoppuVille JalkanenAnne KuitunenMarkus LevorantaJaakko LångsjöSanna RistimäkiKaisa MalilaAnna WoottenSimo VarilaMikko JärvisaloOuti InkinenSatu KentalaKeijo LeivoPaivi HaltiaDidier DreyfussJean-Damien RicardJonathan MessikaAbirami TiagarajahMalo EmeryAline DechanetCoralie GernezDamien RouxLaurent Martin-LefevreMaud FiancetteIsabelle VinatierJean Claude LacheradeGwenhaël ColinChristine LebertMarie-Ange AzaisAihem YehiaCaroline PoupletMatthieu Henry- LagarrigueAmélie SeguinLaura CrosbyJulien MaizelDimitri Titeca-BeauportAlain CombesAnia NieszkowskaPaul MasiAlexandre DemouleJulien MayauxMartin DresElise MorawiecMaxens DecalveleSuela DemiriMorgane FaureClémence MariosMaxime MalletMarie Amélie OrdonLaura MorizotMarie CantienFrançois PoussetStéphane GaudryFlorent PoirsonYves CohenLaurent ArgaudMartin CourLaurent BitkerMarie SimonRomain HernuThomas BaudrySylvie de la SalleAdrien RobineNicholas SedillotXavier TchenioCamille BouisseSylvie RouchSaber Davide BarbarRémi TrussonFabienne TamionSteven GrangéDorothée CarpentierGuillaume ChevrelLuis Ensenyat-MartinSophie MarqueJean-Pierre QuenotPascal AndreuAuguste DargentAudrey LargeNicolas ChudeauMickael LandaisBenoit DerrienJean Christophe CallahanChristophe GuittonCharlène Le MoalAlain RobertKarim AsehnouneRaphael CinottiNicolas GrillotDominique DemeureChristophe VinsonneauImen RahmaniMehdi MarzoukThibault DekeyserCaroline SejourneMélanie VerlayFabienne TheveninLucie DelecolleDidier TheveninBertrand SouweineElisabeth CoupezMireille AddaJean-Pierre EraldiAntoine MarchalotNicolas de ProstArmand Mekontso DessapKeyvan RazaziFerhat MezianiJulie Boisrame-HelmsRaphaël Clere-JehlXavier DelabrancheChristine KummerlenHamid MerdjiAlexandra MonnierYannick RabouelHassene RahmaniHayat AllamSamir ChenafVincenta FranjaBertrand PonsMichel CarlesFrédéric MartinoRégine RichardBenjamin ZuberGuillaume LacaveKarim LakhalBertrand RozecHoa Dang VanÉric BouletFouad FadelCedric CleophaxNicolas DufourCaroline GrantMarie ThuongJean ReignierEmmanuel CanetLaurent NicoletThierry BoulainMai-Anh NayDalila BenzekriFrançois BarbierAnne BretagnolToufik KamelArmelle MathonnetGrégoire MullerMarie SkarzynskiJulie RossiAmandine PradetSandra dos SantosAurore GueryLucie MullerLuis FelixJulien BohéGuillaume ThiéryNadia AissaouiDamien VimpereMorgane CommeureucJean-Luc DiehlEmmanuel GuerotOrfeas LiangosMonika WittigAlexander ZarbockMira KüllmarThomas van WaegeninghNadine RosenowAlistair NicholKathy BrickellPeter DoranPatrick MurrayGiovanni LandoniRosalba LemboAlberto ZangrilloGiacomo MontiMargherita TozziMatteo MarzaroliGaetano LombardiGianluca PaternosterMichelangelo VitielloShay McguinnessRachael ParkeMagdalena ButlerEileen GilderKeri-Anne CowdreySamantha WallaceJane HallionMelissa WoolettPhilippa NealKarina DuffyStephanie LongColin McarthurCatherine SimmondsYan ChenRachael McconnochieLynette NewbyDavid KnightSeton HendersonJan MehrtensStacey MorganAnna MorrisKymbalee Vander HaydenTara BurkeMatthew BaileyRoss FreebairnLesley ChadwickPenelope ParkChristine RollsLiz ThomasUlrike BuehnerErin WilliamsJonathan AlbrettSimon KirkhamCarolyn JacksonTroy BrowneJennifer GoodsonDavid JacksonJames HoughtonOwen CallenderVicki HigsonOwen KeetClive DominyPaul YoungAnna HuntHarriet JuddCassie LawrenceShaanti OlatunjiYvonne RobertsonCharlotte Latimer-BellDeborah HendryAgnes Mckay-VucagoNina BeehreEden LesonaLeanlove NavarraChelsea RobinsonRyan JangAndrea JungeBridget LambertAntoine SchneiderMichel ThibaultPhilippe EckertSébastien KisslingErietta PolychronopoulosElettra PoliMarco AltarelliMadeleine SchnorfSamia Abed MallairdClaudia HeideggerAurelie PerretPhilippe MontillierFrederic SanglaSeigenthaller NeilsAude de WattevilleMandeep-Kaur PhullAparna GeorgeNauman HussainTatiana PogrebanSteve LobazAlison DanielsMishell CunninghamDeborah KerrAlice NicholsonPradeep ShanmugasundaramJudith AbramsKatarina MansoGeraldine HambrookElizabeth MckerrowJuvy SalvaStephen FoulkesMatthew WiseMatt MorganJenny BrooksJade ColeTracy Michelle DaviesHelen HillEmma ThomasMarcela VizcaychipiBehrad BaharloJaime CarungcongPatricia CostaLaura MartinsRitoo KapoorTracy HazeltonAngela MoonJanine MusselwhiteBen ShelleyPhilip MccallMarlies OstermannGill ArbaneAneta BociekMartina MarottiRosario LimSara CamposNeus Grau NovellasArmando CennamoAndrew SlackDuncan WyncollLuigi CamporotaSimon SparkesRosalinde TilleyAustin RattrayGayle MorelandJane DuffyElizabeth McgonigalPhilip HopkinsClare FinneyJohn SmithHarriet NobleHayley WatsonClaire-Louise HarrisEmma ClareyEleanor CorcoranJames BeckClare HowcroftNora YoungsElizabeth WilbyBethan OggAdam WolversonSandra LeeSusie ButlerMaryanne OkubanjoJulia HindleIngeborg WeltersKaren WilliamsEmily JohnsonJulie Patrick-HeseltonDavid ShawVictoria WaughRichard StewartEsther MwauraLynn WrenLouise MewSara-Beth SutherlandJane AdderleyJim RuddyMargaret HarkinsCallum KayeTeresa ScottWendy MitchellFelicity AndersonFiona WilloxVijay JagannathanMichele ClarkSarah PurvAndrew SharmanMegan MeredithLucy RyanLouise ConnerCecilia PetersDan HarveyAshraf RoshdyAmy CollinsMalcolm SimSteven HendersonNigel CheeSally PittsKatie BowmanMaria DilawershahLuke VamplewElizabeth HowePaula RogersClara HernandezClara PrendergastJane BentonAlex RosenbergLui ForniAlice GrantPaula CarvelliAjay RaithathaSarah BirdMax RichardsonMatthew NeedhamClaire HirstJonathan BallSusannah LeaverLuisa HowlettCarlos Castro DelgadoSarah Farnell-WardHelen FarrahGeraldine GrayGipsy JosephFrancesca RobinsonAscanio TridenteClare HarropKaren ShukerDerek MclaughlanJudith RamseySharon MeehanBernd Oliver RoseRosie Reece-AnthonyBabita GurungTony WhitehouseCatherine SnelsonTonny VeenithAndy JohnstonLauren CooperRon CarreraKaren EllisEmma FellowsSamanth HarkettColin BerginElaine SpruceLiesl DespyStephanie GoundryNatalie DooleyTracy MasonAmy ClarkGemma DignamGeraldine WardBen AttwoodPenny ParsonsSophie MasonMichael MargarsonJenny LordPhilip McgloneLuke HodgsonIndra ChadbournRaquel GomezJordi MargalefRinus PretoriusAlexandra HamshereJoseph CarterHazel CahillLia GraingerKate HowardGreg ForshawZoe GuyKianoush KashaniRobert AlbrightAmy AmsbaughAnita StoltenbergAlexander NivenMatthew LynchAnnmarie O’maraSyed NaeemSairah SharifJoyce Mckenney GoulartMatthew LynchAnnmarie O’maraSyed NaeemSairah SharifJoyce Mckenney GoulartAshita TolwaniClaretha LyasLaura LattaAzra BihoracHaleh HashemighouchaniPhilip EfronMatthew RuppertJulie CupkaSean KileyJoshua CarsonPeggy WhiteGeorge OmalaySherry BrownLaura VelezAlina MarceronJavier NeyraJuan Carlos AycinenaMadona EliasVictor Ortiz-SorianoCaroline HauschildRobert Dorfman
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework. Methods We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zero–one inflated beta regression. Results The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI] − 3.30%; 3.40%], − 0.39% [95% CrI − 3.46%; 3.00%], and 0.64% [95% CrI − 2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference of − 3.55 days [95% CrI − 6.38; − 0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrI − 1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66. Conclusions In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : David MalkaNicolas GirardDavid M SmadjaChristine ChevreauStéphane CulineAnne LesurRoman RouzierFrançois RozetJean-Philippe SpanoJean-Yves Blay
• Organismes : Dynamique des cellules tumorales Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans Bulletin du Cancer le 01/11/2020

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Fichiers liés : [Prophylaxis and management of cancer-associated thrombosis Practical issues about anticoagulant use]..pdf

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