Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Stéphane GaudryFrançois GrolleauSaber BarbarLaurent Martin-LefevreBertrand PonsÉric BouletAlexandre BoyerGuillaume ChevrelFlorent MontiniJulien BoheJulio BadieJean-Philippe RigaudChristophe VinsonneauRaphaël PorcherJean-Pierre QuenotDidier Dreyfuss
• Organismes : CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Methods of therapeutic evaluation of chronic diseases | Méthodes de l’évaluation thérapeutique des maladies chroniques Centre d'épidémiologie Clinique [Hôtel-Dieu] Hôpital Universitaire Carémeau [Nîmes] Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon CHU Pointe-à-Pitre / Abymes [Guadeloupe] Groupe hospitalier Carnelle Portes de l'Oise Centre Hospitalier Universitaire de Bordeaux Centre Hospitalier Sud Francilien Centre Hospitalier Henri Duffaut (Avignon) Centre Hospitalier Lyon Sud [CHU - HCL] Hôpital Nord Franche-Comté [Hôpital de Trévenans] Centre hospitalier de Dieppe Centre Hospitalier de Béthune Beuvry Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques Methods of therapeutic evaluation of chronic diseases | Méthodes de l’évaluation thérapeutique des maladies chroniques Centre d'épidémiologie Clinique [Hôtel-Dieu] Equipe LIPNESS (LNC - U1231) CoRaKiD - Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: Intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) are the two main RRT modalities in patients with severe acute kidney injury (AKI). Meta-analyses conducted more than 10 years ago did not show survival difference between these two modalities. As the quality of RRT delivery has improved since then, we aimed to reassess whether the choice of IHD or CRRT as the first modality affects survival of patients with severe AKI. Methods: This is a secondary analysis of two multicenter randomized controlled trials (AKIKI and IDEAL-ICU) that compared an early RRT initiation strategy with a delayed one. We included patients allocated to the early strategy in order to emulate a trial where patients would have been randomized to receive either IHD or CRRT within twelve hours after the documentation of severe AKI. We determined each patient’s modality group as the first RRT modality they received. The primary outcome was 60-day overall survival. We used two propensity score methods to balance the differences in baseline characteristics between groups and the primary analysis relied on inverse probability of treatment weighting. Results: A total of 543 patients were included. Continuous RRT was the first modality in 269 patients and IHD in 274. Patients receiving CRRT had higher cardiovascular and total-SOFA scores. Inverse probability weighting allowed to adequately balance groups on all predefined confounders. The weighted Kaplan–Meier death rate at day 60 was 54·4% in the CRRT group and 46·5% in the IHD group (weighted HR 1·26, 95% CI 1·01–1·60). In a complementary analysis of less severely ill patients (SOFA score: 3–10), receiving IHD was associated with better day 60 survival compared to CRRT (weighted HR 1.82, 95% CI 1·01–3·28; p < 0.01). We found no evidence of a survival difference between the two RRT modalities in more severe patients. Conclusion: Compared to IHD, CRRT as the first modality seemed to convey no benefit in terms of survival or of kidney recovery and might even have been associated with less favorable outcome in patients with lesser severity of disease. A prospective randomized non-inferiority trial should be implemented to solve the persistent conundrum of the optimal RRT technique.

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Fichiers liés : s13054-022-03955-9.pdf

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Luis Felipe ReyesSrinivas MurthyEsteban Garcia-GalloLaura MersonElsa Ibáñez-PradaJordi RelloYuli FuentesIgnacio Martin-LoechesFernando BozzaSara DuqueFabio TacconeRobert FowlerChristiana KartsonakiBronner GonçalvesBarbara Wanjiru CitarellaDiptesh AryalErlina BurhanMatthew CummingsChristelle DelmasRodrigo DiazClaudia Figueiredo-MelloMadiha HashmiPrasan Kumar PandaMiguel Pedrera JiménezDiego Fernando Bautista RinconDavid ThomsonAlistair NicholJohn MarshallPiero OlliaroAli AbbasSheryl Ann AbdukahilRyuzo AbeLaurent AbelLara AbsilSubhash AcharyaAndrew AckerDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimRazi AlalqamTala Al-DabbousSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliNaseem Ali ShahKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouAneela AltafJoão AlvesJoão Melo AlvesRita AlvesJoana Alves CabritaMaria AmaralPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalAngel AsensioNamra AsifMohammad AsimJean Baptiste AssieAnika AtiqueA. 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DarshanaShiranee SriskandanSarah StablerThomas StaudingerStephanie-Susanne StecherYmkje StienstraBirgitte StiksrudEva StolzAmy StoneAdrian Streinu-CercelAnca Streinu-CercelAmi StuartDavid StuartGabriel SuenJacky SuenAsfia SultanaCharlotte SummersDubravka SupicMagdalena SurovcováAndrey SvistunovKonstantinos SyrigosJaques SztajnbokKonstanty SzuldrzynskiShirin TabriziLysa TaghersetSara TalebJelmer TalsmaMaria Lawrensia TampubolonHiroyuki TanakaHuda TaqdeesArshad TaqiCoralie TardivonPierre TattevinM. Azhari TaufikHassan TawfikRichard TedderJoão TeixeiraSofia TejadaMarie-Capucine TellierFrançois TéouléPleun TerpstraOlivier TerrierNicolas TerziHubert Tessier-GrenierAdrian TeyAnand ThakurV. ThibaultSimon-Djamel ThibervilleBenoît ThillShaun ThompsonEmma ThomsonRyan ThwaitesPaul TierneyVadim TieroshynPeter TimashevJean-François TimsitBharath Kumar Tirupakuzhi VijayaraghavanNoémie TissotMaria TokiKristian TonbyMarta TorreAntoni TorresMargarida TorresHernando Torres-ZevallosMichael TowersTony TrapaniThéo TreouxCécile TromeurIoannis TrontzasTiffany TrouillonJeanne TruongChristelle TualSarah TubianaHelen TuiteJean-Marie TurmelLance TurtlePawel TwardowskiMakoto UchiyamaP. UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsLuís Val-FloresAmélie ValranStijn van de VeldeMarcel van den BergeJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van Der WerfLaura van GulikJarne van HattemCarolien van NettenIlonka van VeenNoémie VanelHenk VanoverscheldePooja VargheseCharline VauchyAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJames VickersJosé Ernesto VidalCésar VieiraDeepak VijayanJoy Ann VillanuevaJudit VillarPierre-Marc VilleneuveAndrea VilloldoBenoit VisseauxHannah VisserChiara VitielloHarald VonkemanFanny VuottoWan Fadzlina Wan Muhd ShukeriChih-Hsien WangSteve WebbJia WeiKatharina WeilSanne WesseliusT. Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSuzette WillemsVirginie WilliamsEvert-Jan WilsNg Wing YiuCalvin WongIoannis XynogalasMasaki YamazakiYazdan YazdanpanahCécile YelnikStephanie YerkovichToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeMaram ZahranMaria ZambonAlberto ZanellaHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : University of Oxford Universidad de La Sabana [Chía, Cundinamarca, Colombia] = La Sabana University [Chía, Cundinamarca, Colombia] Infection, Anti-microbiens, Modélisation, Evolution University of Oxford ARN régulateurs bactériens et médecine Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut Pasteur [Paris] Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.

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Fichiers liés : s13054-022-04155-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Kamil PolokJakub FronczekAntonio ArtigasHans FlaattenBertrand GuidetDylan de LangeJesper FjølnerSusannah LeaverMichael BeilSigal SviriRaphael Romano BrunoBernhard WernlyBernardo Bollen PintoJoerg SchefoldDorota StudzińskaMichael JoannidisSandra OeyenBrian MarshFinn AndersenRui MorenoMaurizio CecconiChristian JungWojciech SzczeklikPhilipp EllerMichael JoannidisDieter MesottenPascal ReperSandra OeyenWalter SwinnenHelene BrixJens BrushoejMaja VillefranceHelene Korvenius NedergaardAnders Thais BjerregaardIda Riise BallebyKasper AndersenMaria Aagaard HansenStine UhrenholtHelle BundgaardJesper FjølnerAliae HusseinRehab SalahYasmin Khairy Nasreldin Mohamed AliKyrillos WassimYumna ElgazzarSamar TharwatAhmed AzzamAyman Abdelmawgoad HabibHazem Maarouf AbosheaishaaMohammed AzabSusannah LeaverArnaud GalboisBertrand GuidetCyril CharronEmmanuel GuerotGuillaume BeschJean-Philippe RigaudJulien MaizelMichel DjibréPhilippe BurtinPierre GarconSaad NseirXavier ValetteNica AlexandruNathalie MarinMarie VaissiereGaëtan PlantefeveThierry VanderlindenIgor JurcisinBuno MegarbaneAnais CaillardArnaud ValentMarc GarnierSebastien BessetJohanna OzielJean-Herlé RaphalenStéphane DaugerGuillaume DumasBruno GoncalvesGaël PitonEberhard BarthUlrich GoebelEberhard BarthAnselm KunsteinMichael SchusterMartin WelteMatthias LutzPatrick MeybohmStephan SteinerTudor PoernerHendrik HaakeStefan SchallerStefan SchallerStefan SchallerDetlef Kindgen-MillesChristian MeyerMuhammed KurtKarl Friedrich KuhnWinfried RanderathJakob WollbornZouhir DindaneHans-Joachim KabitzIngo VoigtGonxhe ShalaAndreas FaltlhauserNikoletta RovinaZoi AidoniEvangelia ChrisanthopoulouAntonios PapadogoulasMohan GurjarAta MahmoodpoorAbdullah Khudhur AhmedBrian MarshAhmed ElsakaSigal SviriVittoria ComelliniAhmed RabhaHazem AhmedSilvio Namendys-SilvaAbdelilah GhannamMartijn GroenendijkMarieke ZegersDylan de LangeAlex CornetMirjam EversLenneke HaasTom DormansWillem DieperinkLuis RomundstadBritt SjøbøFinn AndersenHans Frank StrietzelTheresa OlasveengenMichael HahnMiroslaw CzuczwarRyszard GawdaJakub KlimkiewiczMaria de Lurdes Campos SantosAndré GordinhoHenrique SantosRui AssisAna Isabel Pinho OliveiraMohamed Raafat BadawyDavid Perez-TorresGemma GomàMercedes Ibarz VillamayorAngela Prado MiraPatricia Jimeno CuberoSusana Arias RiveraTeresa TomasaDavid IglesiasEric Mayor VázquezCesar AldecoaAida Fernández FerreiraBegoña Zalba-EtayoIsabel Canas-PerezLuis Tamayo-LomasCristina Diaz-RodriguezSusana SanchoJesús PriegoEnas AbualqumbozMomin Majed Yousuf HillesMahmoud SalehNawfel Ben-HamoudaAndrea RobertiAlexander DullenkopfYvan FleuryBernardo Bollen PintoJoerg SchefoldMohammed Al-Sadawi
• Organismes : Institut Pierre Louis d'Epidémiologie et de Santé Publique Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Noninvasive ventilation (NIV) is a promising alternative to invasive mechanical ventilation (IMV) with a particular importance amidst the shortage of intensive care unit (ICU) beds during the COVID-19 pandemic. We aimed to evaluate the use of NIV in Europe and factors associated with outcomes of patients treated with NIV. Methods This is a substudy of COVIP study—an international prospective observational study enrolling patients aged ≥ 70 years with confirmed COVID-19 treated in ICU. We enrolled patients in 156 ICUs across 15 European countries between March 2020 and April 2021.The primary endpoint was 30-day mortality. Results Cohort included 3074 patients, most of whom were male (2197/3074, 71.4%) at the mean age of 75.7 years (SD 4.6). NIV frequency was 25.7% and varied from 1.1 to 62.0% between participating countries. Primary NIV failure, defined as need for endotracheal intubation or death within 30 days since ICU admission, occurred in 470/629 (74.7%) of patients. Factors associated with increased NIV failure risk were higher Sequential Organ Failure Assessment (SOFA) score (OR 3.73, 95% CI 2.36–5.90) and Clinical Frailty Scale (CFS) on admission (OR 1.46, 95% CI 1.06–2.00). Patients initially treated with NIV (n = 630) lived for 1.36 fewer days (95% CI − 2.27 to − 0.46 days) compared to primary IMV group (n = 1876). Conclusions Frequency of NIV use varies across European countries. Higher severity of illness and more severe frailty were associated with a risk of NIV failure among critically ill older adults with COVID-19. Primary IMV was associated with better outcomes than primary NIV. Clinical Trial Registration NCT04321265 , registered 19 March 2020, https://clinicaltrials.gov .

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Chiara RobbaRafael BadenesDenise BattagliniLorenzo BallFilippo SanfilippoIole BrunettiJanus Christian JakobsenGisela LiljaHans FribergPedro David Wendel-GarciaPaul YoungGlenn EastwoodMichelle ChewJohan UndenMatthew ThomasMichael JoannidisAlistair NicholAndreas LundinJacob HollenbergNaomi HammondManoj SaxenaAnnborn MartinMiroslav SolarFabio Silvio TacconeJosef DankiewiczNiklas NielsenAnders Morten GrejsFlorian EbnerPaolo PelosiJan BělohlávekClifton CallawayAlain CariouTobias CronbergDavid ErlingeJan HovdenesHans KirkegaardHelena LevinMatt MorganPer NordbergMauro OddoChristian RylanderChristian StormSusann UllénMatt WiseKathy RowanDavid HarrisonPaul MounceyManu Shankar-HariDuncan YoungTheis LangeKarolina PalmérUlla-Britt KarlssonSimon HeisslerFrances BassJohn MyburghColman TaylorAdele BellinoMarwa Abel-AllBen FinferCarolyn KochYang LiAnne O’connorJulia PilowskyTina SchneiderAnna TippettBridget AdyTessa BroadleyAmanda BrownLiz MelgaardMimi MorganVanessa SinghRebecca SymonsKathrin BeckerNathalie SanteVendula SaleovaSilvie ZerzanovaSamia Sefir-KribelUte LübeckMartina CarraraKathryn FernandoDiane MackleLeanlove NavarraJudith RileyElin WesterheimMarianne FlatebøAmeldina CericZana HaxhijaLovisa TerlingLena BossmarLiz JergleHelén Holm MånssonSamia Abed MaillardAndreja Vujicic ZagarChristina JodlaukJennifer ScrivensKate AinscoughCiara FaheyRinaldo BellomoLeah PeckHelen YoungWinston CheungRosalba CrossMichael HayesNitin JainMark KolAsim ShahAtul WaghHelen WongF. Eduardo MartinezGail BrinkerhoffDustin BushAntony StewartAnders AnemanLien LombardoPeter MccannyJames PenkethIan SeppeltRebecca GreshamJulie LowreyKristy MastersChristina WhiteheadJames WalshamMeg HarwardJosephine MackayJason MeyerEmma SaylorEllen VenzKrista WetzigWade StedmanAngela AshelfordSharon MarMiyuki TokumitsuElizabeth YaradHergen BuscherClaire ReynoldsAndrew UdyAidan BurrellJasmin CollinsDashiell GantnerVictoria Emma-Leah MartinPhoebe MccrackenVinodh NanjayyaAlexander Sacha RichardsonMeredith YoungAngaj GhoshSimone SaidRonny BeerFrank HartigRaimund HelbokSebastian KleinAndreas PeerJacques CreteurDominique DurandMatthias DupontSigrid ChristiaensCarola ClaesSebastiaan DeckxBert FerdinandeSanne LenaertsWilifred MullensSarah StroobantsEvi TheunissenDavid VerhaertOndřej ŠmídMarek FlaksaDavid KemlinkJan MalíkMichal OtáhalJan RulíšekMichal ŠíranecZdeněk StachAnna ValeriánováPetra ZavadilovaMiroslav SolařRóber BánszkyJana ČervenáRenata Černá PařízkováLibor ŠimůnekFilip VarhaníkJiří KarásekMatěj StrýčekAnders GrejsSteffen ChristensenPeter Juhl-OlsenIda Katrine ThomsenLisa Gregersen ØstergaardAlbert CaoPierre DuplandAriane GavaudPaul JaubertMathieu JozwiakNathalie MarinGuillaume SavaryNicolas DeyeBruno MégarbanePierre MoraLaetitia SutterlinStephane LegrielHugo BellutAlexis FerreGuillaume LacaveMarine PaulJean-Baptiste LascarrouEmmanuel CanetCharlotte GarretArnaud Felix MiaihleJean ReignierPhilippe VignonThomas DaixArnaud DesachyBruno EvrardBruno FrancoisAnne-Laure FedouMarine GoudelinChristoph LeithnerJens NeeKaspar Josche StreitbergerGiulia BonattiIacopo FirpoPaolo FrisoniArianna IachiSimona MaianiMaura MandelliFabio TarantinoAlberto BarbieriElisabetta BertelliniEnrico GiulianiGabriele MelegariErik Roman-PognuzGiorgio BerlotUmberto LucangeloElisabetta MacchiniVibeke AuneTomas DrægniSimon JacobsenSøren PieschkeÅse RasmussenGro Ringstad AkselsenHalvor LangelandDaniel BergumTherese ErbePål KlepstadHelle NæssRoy Bjørkholt OlsenLena Eriksen SkjelnesMarius HolenJoakim Iver PostRune FanebustLinda Hårteig SørensenKen Åge KårstadCarstenfredrik WickmanColin BarnesBen BarryNina BeehreDick DinsdaleSam EdneyAnna HuntHarriet JuddCharlotte Latimer-BellCassie LawrenceJames MooreShaanti OlatunjiAlex PsiridesChelsea RobinsonKate TietjensJason WrightDavid KnightBrandon BirkerDavid BowieTara BurkeDavid CloseyRosalind CrombieNeil DavidsonSeton HendersonLouise HitchingsJames MckayJan MehrtensEmmeline MintoStacey MorganAnna MorrisJay Ritzemar-CarterJessica RobertsGeoffrey ShawKatherine TownendKymbalee Vander HeydenMarita AhlqvistRoman Desta LindgrenIngrid EivingPatrik MartnerElisabeth MyhrmanBirgitta RydingJoachim DüringMattias BergströmMattias BohmIngrid DidrikssonPetrea FridKatarina HeimburgMarina LarssonOscar LundbergStefan Olsson HauSimon SchmidbauerOla BorgquistAnne AdolfssonAnna BjärnroosErik Blennow-NordströmIrina DraganceaThomas KanderAnna LybeckGustav MattiassonOlof PerssonMalin RundgrenSusann SchreyErik WesthallMartin AnnbornSara AndertunNerida GustavssonLisa HasselJesper JohnssonMarie NelderupHeléne PeterssonJörgen PeterssonFrideriki StafilidouJohan UndénFrida AntonssonGit BergmanJörgen GamrothMaria MeirikKatarina RudolfssonHelena SandbergMartin ThorssonKristin SavolainenMaria HansboMalin HellikssonBjörne NödtveidtJohan SannerVictoria SemCamilla Sund LindquistAkil AwadAnna-Sofia BörjessonMalin HedbergMia HenningPer PetersenEmelia DahlbergJohan ForshammarVeronica SvenssonMichael WanecekHåkan EskilssonDaniel Rodriguez-SantosÅsa AppelqvistHenrietta JidbrattElisabeth JohanssonLars KiszakiewiczÅsa NilssonSinnika OlssonAnders PaulssonUrszula StempelAndreas ThorenStefan PerssonIda BerglundEric BergströmCathrine TörnqvistIngela ÖstmanSten RubertssonIng-Marie LarssonElin SödermanEwa WallinJoanna WessberghThomas HallidayFilippa EngvallNawfel Ben-HamoudaAdriano BerniniPierre-Nicolas CarronPhilippe EckertEva FavreJohn-Paul MirozPaola MorelliOlivier MullerJan NoviAndrea RossetiMadeleine SchnorfMatthias HaenggiAnja LevisSandra NansozNicole SöllClaudia SchragMensur AlicajicPhilipp BaierJoel DütschlerDominique FlügelEdith FässlerRuth Gamio-VeisMarc GüpfertYvonne HilpertshauserStefan Hägele-LinkGian-Reto KlegerPeter KrähenmannMaria Elisabeth MairNadja SchaiChristoph StrohmaierPeter TanglDominik ZieglgänsbergerMarco MaggioriniGabriele ClausGabi Consani-VogelLukas ImbachSamira KaiserEva-Maria KleinertPedro David Wendel GarciaTiziano CassinaPamela AgazziBruno CapelliGabriele CassoMartino RegazziHervé SchlotterbeckGabriele ViaMichele VillaJenny BrooksEve CocksJade ColeJacqueline CurtinMichelle DaviesRhys DaviesStephen FernandezJulie HighfieldHelen HillLydia PennantSofia RoseEmma ThomasAngharad WilliamsPeter McguiganStephen HaffeyAisling O’neillKathryn WardJeremy BewleyAnna ChillingworthJulie CloakeLibby ColeHilary GalvinZoe GarlandLisa GrimmerBethany GumbrillLucy HowieRebekah JohnsonChloe SearlesAgnieszka SkorkoKatie SweetVictoria TaylorDenise WebsterThomas KeebleGill AdamsRajesh AggarwalJo-Anne CartwrightSteven ChurchGerald CleshamJohn DaviesKelly FarrellReto GammaJane HardingRohan JagathesanAlamgir KabirPaul KellyLauren KittridgeMaria MaccaroniGracie MaloneyMarco MionNaveen NainRaghunath NalgirkarGyanesh NamjoshiStacey PepperEmily RedmanJeremy SayerAmanda SolesburyKare TangSali UroviKunal WaghmareNoel WatsonTeresa WebberPeter IsherwoodConor BentleyColin BerginRonald CarreraAmy ClarkLauren CooperLiesl DespyNatalie DooleyKaren EllisEmma FellowsStephanie GoundrySamantha HarkettChristopher McgheeAoife NealHazel SmithCatherine SnelsonElaine SpruceTony WhitehouseKamal YakoubAndrew WaldenShauna BartleyParminder BhuieMatthew FriseNicola JacquesLiza KeatingDavid PogsonZoe DalySteve RoseJonathan Bannard-SmithRachael QuayleNigel CheeNina BarrattKatie BowmanDebbie BranneyElizabeth HoweMaria LettsSally PittsLuke VamplewClifton CallawaySara Difiore SprouseAnkur DoshiJennifer FugateAmy HeadleeEelco Wijdicks
• Organismes : Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO 2 ) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO 2 with patients’ outcome. Methods Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO 2 < 60 mmHg and severe hyperoxemia as PaO 2 > 300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO 2 -AUC), for hyperoxemia was significantly associated with mortality ( p = 0.003). Conclusions In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration : clinicaltrials.gov NCT02908308 , Registered September 20, 2016.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Fernando ZampieriBruno da CostaSuvi VaaraFrançois LamontagneBram RochwergAlistair NicholShay McguinnessDanny McauleyMarlies OstermannRon WaldSean BagshawSean BagshawRon WaldNeill AdhikariRinaldo BellomoDidier DreyfussBin DuMartin GallagherStéphane GaudryFrançois LamontagneMichael JoannidisKathleen LiuDaniel McauleyShay McguinnessAlistair NicholMarlies OstermannPaul PalevskyHaibo QiuVille PettiläAntoine SchneiderOrla SmithSuvi VaaraMatthew WeirRinaldo BellomoGlenn EastwoodLeah PeckHelen YoungPeter KrugerGordon LaurieEmma SaylorJason MeyerEllen VenzKrista WetzigCraig FrenchForbes McgainJohn MulderGerard FennessySathyajith KoottayiSamantha BatesMiriam TownsRebecca MorganAnna TippettAndrew UdyChris MasonElisa LicariDashiell GantnerJason McclureAlistair NicholPhoebe MccrackenJasmin BoardEmma MartinShirley VallanceMeredith YoungChelsey VladicSteve McgloughlinDavid GattasHeidi BuhrJennifer ColesDebra HutchJames WunLouise ColeChristina WhiteheadJulie LowreyKristy MastersRebecca GreshamVictoria CampbellDavid GutierrezJane BrailsfordLoretta ForbesLauren MurrayTeena MaguireMartina NichonghaileNeil OrfordAllison BoneTania ElderkinTania SalernoTim ChimundaJason FletcherEmma BroadfieldSanjay PorwalCameron KnottCatherine BoschertJulie SmithAngus RichardsonDianne HillGraeme DukePeter OziemskiSantiago CegarraPeter ChanDeborah WelshStephanie HunterOwen RoodenburgJohn DyettNicos KokotsisMax MoserYang YangLaven PadayacheeJoseph VetroHimangsu GangopadhyayMelissa KaufmanAngaj GhoshSimone SaidAlpesh PatelShailesh BihariElisha MathesonXia JinTapaswi ShresthaKate SchwartzMartin GallagherRosalba CrossWinston CheungHelen WongMark KolAsim ShahAmanda WangZoltan EndreCelia BradfordPierre JaninSimon FinferNaomi DielJonathan GatwardNaomi HammondAnthony DelaneyFrances BassElizabeth YaradHergen BuscherClaire ReynoldsNerilee BakerMichael JoannidisRomuald BellmannAndreas PeerJulia HasslacherPaul KoglbergerSebastian KleinKlemens ZotterAnna BrandtnerArmin FinkenstedtAdelheid DitlbacherFrank HartigDietmar FriesMirjam BachlerBettina SchenkMartin WagnerPhilipp EllerThomas StaudingerEsther TillerPeter SchellongowskiAndja BojicEric HosteStephanie BrackeLuc de CropDaisy VermeirenFernando ThomeBianca ChiellaLucia FendtVeronica AntunesJean-Philippe LafranceFrançois LamontagneFrédérick D’aragonCharles St-ArnaudMichael MayetteÉlaine CarbonnaeuJoannie MarchandMarie-Hélène MasseMarilène LadouceurAlexis TurgeonFrançois LauzierDavid BellemareCharles Langis FrancoeurGuillaume LeblancGabrielle GuilbaultStéphanie GrenierEve CloutierAnnick BoivinCharles Delisle-ThibaultPanagiota GiannakourosOlivier CosterousseJean-François CailhierFrançois-Martin CarrierAli GhamraouiMartine LebrasseurFatna BenettaibMaya SalaméDounia BoumahniYing Tung SiaJean-François NaudIsabelle RoyHenry StelfoxStacey RuddellBraden MannsShelley DugganDominic CarneyJennifer BarchardRichard WhitlockEmilie Belley-CoteNevena SavijaAlexandra SabevTroy CampbellThais CrearyKelson DevereauxShira BrodutchClaudio RigattoBojan PaunovicOwen MooneyAnna GlybinaOksana HarasemiwMichelle Di NellaJohn HarmonNavdeep MehtaLouis LakatosNicole HaslamFrancois LelloucheMathieu SimonYing TungPatricia LizottePierre-Alexandre BourchardBram RochwergTim KarachiTina MillenJohn MuscedereDavid MasloveJ. Gordon BoydStephanie SibleyJohn DroverMiranda HuntIlinca GeorgescuRandy WaxIlan LengaKavita SridharAndrew SteeleKelly FuscoTaneera GhateMichael TolibasHolly RobinsonMatthew WeirRavi TanejaIan BallAmit GargEileen CampbellAthena OvsenekSean BagshawSean van DiepenNadia BaigSheldon MagderHan YaoAhsan AlamJosie CampisiErika MacintyreElla RokoshKimberly ScherrStephen LapinskySangeeta MehtaSumesh ShahDaniel NivenHenry StelfoxStacey RuddellMichael RussellKym JimGillian BrownKerry OxtobyAdam HallLuc BenoitColleen SokolowskiBhanu PrasadJag RaoShelley GiebelDemetrios KutsogiannisPatricia ThompsonTayne ThompsonRobert CironeKanthi KavikondalaMark SothFrance ClarkeAlyson TakaokaRon WaldDavid MazerKaren BurnsJan FriedrichDavid KleinGyan SandhuMarlene SantosImrana KhalidJennifer HodderPeter DodekNajib AyasVictoria AlcuazGabriel SuenOleksa RewaGurmeet SinghSean NorrisNeil GibsonCastro AriasAysha ShamiCeline PelletierNeill AdhikariAlireza ZahiriehAndre AmaralNicole MarinoffNavjot KaurAdic PerezJane WangGregory HaljanChristopher CondinLauralyn McintyreBrigette GomesRebecca PorteousIrene WatpoolSwapnil HiremathEdward ClarkMargaret HerridgeFelicity BackhouseM. Elizabeth WilcoxKarolina WalczakVincent KiAsheer SharmanMartin RomanoSean BagshawR. Noel GibneyAdam RomanovskyOleksa RewaLorena MccoshenNadia BaigGordon WoodDaniel OvakimFiona AuldGayle CarneyMeili DuanXiaojun JiDongchen GuoZhili QiJin LinMeng ZhangLei DongJingfeng LiuPei LiuDeyuan ZhiGuoqiang BaiYu QiuZiqi YangJing BaiZhuang LiuHaizhou ZhuangHaiman WangJian LiMengya ZhaoXiao ZhouXianqing ShiBaning YeManli LiuJing WuYongjian FuDali LongYu PanJinlong WangHuaxian MeiSongsong ZhangMingxiang WenEnyu YangSijie MuJianquan LiTingting HuBingyu QinMin LiCunzhen WangXin DongKaiwu WangHaibo WangJianxu YangBin DuChuanyao WangDongxin WangNan LiZhui YuSong XuLan YaoGuo HouZhou LiuLiping LuYingtao LianChunting WangJichen ZhangRuiqi DingGuoqing QiQizhi WangPeng WangZhaoli MengMan ChenXiaobo HuXiandi HeShibing ZhaoLele HangRui LiSuhui QinKun LuShijuan DunCheng LiuQi ZhouZhenzhen ChenJing MeiMinwei ZhangHao XuJincan LinQindong ShiLijuan FuQinjing ZengHongye MaJinqi YanLan GaoHongjuan LiuLei ZhangHao LiXiaona HeJingqun FanLitao GuoYu LiuXue WangJingjing SunZhongmin LiuJuan YangLili DingLulu ShengXingang LiuJie YanQuihui WangYifeng WangDan ZhaoShuangping ZhaoChenghuan HuJing LiFuxing DengHaibo QuiYi YangMin MoChun PanChangde WuYingzi HuangLili HuangAiran LiuVille PettiläSuvi VaaraAnna-Maija KorhonenSanna TörnblomSari SutinenLeena PettiläJonna HeinonenEliria LappiTaria SuhonenSari KarlssonSanna HoppuVille JalkanenAnne KuitunenMarkus LevorantaJaakko LångsjöSanna RistimäkiKaisa MalilaAnna WoottenSimo VarilaMikko JärvisaloOuti InkinenSatu KentalaKeijo LeivoPaivi HaltiaDidier DreyfussJean-Damien RicardJonathan MessikaAbirami TiagarajahMalo EmeryAline DechanetCoralie GernezDamien RouxLaurent Martin-LefevreMaud FiancetteIsabelle VinatierJean Claude LacheradeGwenhaël ColinChristine LebertMarie-Ange AzaisAihem YehiaCaroline PoupletMatthieu Henry- LagarrigueAmélie SeguinLaura CrosbyJulien MaizelDimitri Titeca-BeauportAlain CombesAnia NieszkowskaPaul MasiAlexandre DemouleJulien MayauxMartin DresElise MorawiecMaxens DecalveleSuela DemiriMorgane FaureClémence MariosMaxime MalletMarie Amélie OrdonLaura MorizotMarie CantienFrançois PoussetStéphane GaudryFlorent PoirsonYves CohenLaurent ArgaudMartin CourLaurent BitkerMarie SimonRomain HernuThomas BaudrySylvie de la SalleAdrien RobineNicholas SedillotXavier TchenioCamille BouisseSylvie RouchSaber Davide BarbarRémi TrussonFabienne TamionSteven GrangéDorothée CarpentierGuillaume ChevrelLuis Ensenyat-MartinSophie MarqueJean-Pierre QuenotPascal AndreuAuguste DargentAudrey LargeNicolas ChudeauMickael LandaisBenoit DerrienJean Christophe CallahanChristophe GuittonCharlène Le MoalAlain RobertKarim AsehnouneRaphael CinottiNicolas GrillotDominique DemeureChristophe VinsonneauImen RahmaniMehdi MarzoukThibault DekeyserCaroline SejourneMélanie VerlayFabienne TheveninLucie DelecolleDidier TheveninBertrand SouweineElisabeth CoupezMireille AddaJean-Pierre EraldiAntoine MarchalotNicolas de ProstArmand Mekontso DessapKeyvan RazaziFerhat MezianiJulie Boisrame-HelmsRaphaël Clere-JehlXavier DelabrancheChristine KummerlenHamid MerdjiAlexandra MonnierYannick RabouelHassene RahmaniHayat AllamSamir ChenafVincenta FranjaBertrand PonsMichel CarlesFrédéric MartinoRégine RichardBenjamin ZuberGuillaume LacaveKarim LakhalBertrand RozecHoa Dang VanÉric BouletFouad FadelCedric CleophaxNicolas DufourCaroline GrantMarie ThuongJean ReignierEmmanuel CanetLaurent NicoletThierry BoulainMai-Anh NayDalila BenzekriFrançois BarbierAnne BretagnolToufik KamelArmelle MathonnetGrégoire MullerMarie SkarzynskiJulie RossiAmandine PradetSandra dos SantosAurore GueryLucie MullerLuis FelixJulien BohéGuillaume ThiéryNadia AissaouiDamien VimpereMorgane CommeureucJean-Luc DiehlEmmanuel GuerotOrfeas LiangosMonika WittigAlexander ZarbockMira KüllmarThomas van WaegeninghNadine RosenowAlistair NicholKathy BrickellPeter DoranPatrick MurrayGiovanni LandoniRosalba LemboAlberto ZangrilloGiacomo MontiMargherita TozziMatteo MarzaroliGaetano LombardiGianluca PaternosterMichelangelo VitielloShay McguinnessRachael ParkeMagdalena ButlerEileen GilderKeri-Anne CowdreySamantha WallaceJane HallionMelissa WoolettPhilippa NealKarina DuffyStephanie LongColin McarthurCatherine SimmondsYan ChenRachael McconnochieLynette NewbyDavid KnightSeton HendersonJan MehrtensStacey MorganAnna MorrisKymbalee Vander HaydenTara BurkeMatthew BaileyRoss FreebairnLesley ChadwickPenelope ParkChristine RollsLiz ThomasUlrike BuehnerErin WilliamsJonathan AlbrettSimon KirkhamCarolyn JacksonTroy BrowneJennifer GoodsonDavid JacksonJames HoughtonOwen CallenderVicki HigsonOwen KeetClive DominyPaul YoungAnna HuntHarriet JuddCassie LawrenceShaanti OlatunjiYvonne RobertsonCharlotte Latimer-BellDeborah HendryAgnes Mckay-VucagoNina BeehreEden LesonaLeanlove NavarraChelsea RobinsonRyan JangAndrea JungeBridget LambertAntoine SchneiderMichel ThibaultPhilippe EckertSébastien KisslingErietta PolychronopoulosElettra PoliMarco AltarelliMadeleine SchnorfSamia Abed MallairdClaudia HeideggerAurelie PerretPhilippe MontillierFrederic SanglaSeigenthaller NeilsAude de WattevilleMandeep-Kaur PhullAparna GeorgeNauman HussainTatiana PogrebanSteve LobazAlison DanielsMishell CunninghamDeborah KerrAlice NicholsonPradeep ShanmugasundaramJudith AbramsKatarina MansoGeraldine HambrookElizabeth MckerrowJuvy SalvaStephen FoulkesMatthew WiseMatt MorganJenny BrooksJade ColeTracy Michelle DaviesHelen HillEmma ThomasMarcela VizcaychipiBehrad BaharloJaime CarungcongPatricia CostaLaura MartinsRitoo KapoorTracy HazeltonAngela MoonJanine MusselwhiteBen ShelleyPhilip MccallMarlies OstermannGill ArbaneAneta BociekMartina MarottiRosario LimSara CamposNeus Grau NovellasArmando CennamoAndrew SlackDuncan WyncollLuigi CamporotaSimon SparkesRosalinde TilleyAustin RattrayGayle MorelandJane DuffyElizabeth McgonigalPhilip HopkinsClare FinneyJohn SmithHarriet NobleHayley WatsonClaire-Louise HarrisEmma ClareyEleanor CorcoranJames BeckClare HowcroftNora YoungsElizabeth WilbyBethan OggAdam WolversonSandra LeeSusie ButlerMaryanne OkubanjoJulia HindleIngeborg WeltersKaren WilliamsEmily JohnsonJulie Patrick-HeseltonDavid ShawVictoria WaughRichard StewartEsther MwauraLynn WrenLouise MewSara-Beth SutherlandJane AdderleyJim RuddyMargaret HarkinsCallum KayeTeresa ScottWendy MitchellFelicity AndersonFiona WilloxVijay JagannathanMichele ClarkSarah PurvAndrew SharmanMegan MeredithLucy RyanLouise ConnerCecilia PetersDan HarveyAshraf RoshdyAmy CollinsMalcolm SimSteven HendersonNigel CheeSally PittsKatie BowmanMaria DilawershahLuke VamplewElizabeth HowePaula RogersClara HernandezClara PrendergastJane BentonAlex RosenbergLui ForniAlice GrantPaula CarvelliAjay RaithathaSarah BirdMax RichardsonMatthew NeedhamClaire HirstJonathan BallSusannah LeaverLuisa HowlettCarlos Castro DelgadoSarah Farnell-WardHelen FarrahGeraldine GrayGipsy JosephFrancesca RobinsonAscanio TridenteClare HarropKaren ShukerDerek MclaughlanJudith RamseySharon MeehanBernd Oliver RoseRosie Reece-AnthonyBabita GurungTony WhitehouseCatherine SnelsonTonny VeenithAndy JohnstonLauren CooperRon CarreraKaren EllisEmma FellowsSamanth HarkettColin BerginElaine SpruceLiesl DespyStephanie GoundryNatalie DooleyTracy MasonAmy ClarkGemma DignamGeraldine WardBen AttwoodPenny ParsonsSophie MasonMichael MargarsonJenny LordPhilip McgloneLuke HodgsonIndra ChadbournRaquel GomezJordi MargalefRinus PretoriusAlexandra HamshereJoseph CarterHazel CahillLia GraingerKate HowardGreg ForshawZoe GuyKianoush KashaniRobert AlbrightAmy AmsbaughAnita StoltenbergAlexander NivenMatthew LynchAnnmarie O’maraSyed NaeemSairah SharifJoyce Mckenney GoulartMatthew LynchAnnmarie O’maraSyed NaeemSairah SharifJoyce Mckenney GoulartAshita TolwaniClaretha LyasLaura LattaAzra BihoracHaleh HashemighouchaniPhilip EfronMatthew RuppertJulie CupkaSean KileyJoshua CarsonPeggy WhiteGeorge OmalaySherry BrownLaura VelezAlina MarceronJavier NeyraJuan Carlos AycinenaMadona EliasVictor Ortiz-SorianoCaroline HauschildRobert Dorfman
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Critical Care le 31/10/2020

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Résumé : Abstract Background Timing of initiation of kidney-replacement therapy (KRT) in critically ill patients remains controversial. The Standard versus Accelerated Initiation of Renal-Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial compared two strategies of KRT initiation (accelerated versus standard) in critically ill patients with acute kidney injury and found neutral results for 90-day all-cause mortality. Probabilistic exploration of the trial endpoints may enable greater understanding of the trial findings. We aimed to perform a reanalysis using a Bayesian framework. Methods We performed a secondary analysis of all 2927 patients randomized in multi-national STARRT-AKI trial, performed at 168 centers in 15 countries. The primary endpoint, 90-day all-cause mortality, was evaluated using hierarchical Bayesian logistic regression. A spectrum of priors includes optimistic, neutral, and pessimistic priors, along with priors informed from earlier clinical trials. Secondary endpoints (KRT-free days and hospital-free days) were assessed using zero–one inflated beta regression. Results The posterior probability of benefit comparing an accelerated versus a standard KRT initiation strategy for the primary endpoint suggested no important difference, regardless of the prior used (absolute difference of 0.13% [95% credible interval [CrI] − 3.30%; 3.40%], − 0.39% [95% CrI − 3.46%; 3.00%], and 0.64% [95% CrI − 2.53%; 3.88%] for neutral, optimistic, and pessimistic priors, respectively). There was a very low probability that the effect size was equal or larger than a consensus-defined minimal clinically important difference. Patients allocated to the accelerated strategy had a lower number of KRT-free days (median absolute difference of − 3.55 days [95% CrI − 6.38; − 0.48]), with a probability that the accelerated strategy was associated with more KRT-free days of 0.008. Hospital-free days were similar between strategies, with the accelerated strategy having a median absolute difference of 0.48 more hospital-free days (95% CrI − 1.87; 2.72) compared with the standard strategy and the probability that the accelerated strategy had more hospital-free days was 0.66. Conclusions In a Bayesian reanalysis of the STARRT-AKI trial, we found very low probability that an accelerated strategy has clinically important benefits compared with the standard strategy. Patients receiving the accelerated strategy probably have fewer days alive and KRT-free. These findings do not support the adoption of an accelerated strategy of KRT initiation.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Nadim CassirFlorian CardonaHervé Tissot-DupontChristiane BruelBarbara DoudierSalima LahouelKarim BendamardjiCéline BoschiSarah AherfiSophie EdouardJean-Christophe LagierPhilippe ColsonPhilippe GautretPierre-Edouard FournierPhilippe ParolaPhilippe BrouquiBernard La-ScolaMatthieu Million
• Organismes : Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Agence Régionale de la Santé Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Vecteurs - Infections tropicales et méditerranéennes Vecteurs - Infections tropicales et méditerranéennes Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection Microbes Evolution Phylogénie et Infections Institut Hospitalier Universitaire Méditerranée Infection
• Publié dans Emerging Infectious Diseases le 27/10/2020

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Résumé : We enrolled 136 patients with laboratory-confirmed monkeypox during June 4–August 31, 2022, at the University Hospital Institute Méditerranée Infection in Marseille, France. The median patient age was 36 years (interquartile range 31–42 years). Of 136 patients, 125 (92%) were men who have sex with men, 15 (11%) reported previous smallpox vaccinations, and 21 (15.5%) were HIV-positive. The most frequent lesion locations were the genitals (68 patients, 53%), perianal region (65 patients, 49%), and oral/perioral area (22 patients, 17%). Lesion locations largely corresponded with the route of contamination. Most (68%) patients had isolated anal, genital, or oral lesions when they were first seen, including 56 (61%) who had >1 positive site without a visible lesion. Concurrent sexually transmitted infections were diagnosed in 19 (15%) patients, and 7 patients (5%) were asymptomatic. We recommend vaccination campaigns, intensified testing for sexually transmitted infections, and increased contact tracing to control the ongoing monkeypox outbreak.

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Fichiers liés : 22-1440.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Kim GénuitePierre VoinchetJean-Jacques DelannoyJean-Jacques BahainJulien MonneyJudicaël ArnaudLaurent BruxellesMarie-Hélène MoncelAnne PhilippeEdwige Pons-BranchuAndré RevilMaïlys RichardStéphane Jaillet
• Organismes : Environnements, Dynamiques et Territoires de Montagne Histoire naturelle de l'Homme préhistorique Environnements, Dynamiques et Territoires de Montagne Histoire naturelle de l'Homme préhistorique Muséum national d'Histoire naturelle Environnements, Dynamiques et Territoires de Montagne Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés School of Geography, Archaeology and Environmental Studies [Johannesburg] Histoire naturelle de l'Homme préhistorique Laboratoire de Mathématiques Jean Leray Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Institut des Sciences de la Terre Environnements, Dynamiques et Territoires de Montagne Centro Nacional de Investigación sobre la Evolución Humana Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Géochrononologie Traceurs Archéométrie Eberhard Karls Universität Tübingen = University of Tübingen Centre de recherche francais de Jérusalem Environnements, Dynamiques et Territoires de Montagne
• Publié dans Quaternary Science Reviews le 27/10/2020

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Résumé : Most archaeological and palaeo-environmental archives are preserved in specific environments (buried sediments, rock shelters, cave environments). Hence, the information we can obtain is usually incomplete, and lacking spatial and morphological significance. Studying landscape evolution can help us to understand the location and distribution of past societies and their relation to Quaternary environments. In the Ardèche Valley, most Middle and Late Palaeolithic sites are preserved in caves and rock-shelters and in rare cases in fluvial sediments. Here we apply an integrated geomorphological approach to the study of the evolution of the Ardèche Valley combining multi-method dating, geomorphological mapping and surveys of cave and fluvial formations. We review chronological results obtained through multi-method dating (electron spin resonance (ESR), infrared stimulated luminescence (IRSL), uranium-series (U-series), combined electron spin resonance/uranium-series (ESR/U-series)) on cave and riverine objects and combine them with topographic and stratigraphic observations in an integrated Bayesian hierarchical model. The results are in agreement with those obtained from other rivers in mountainous environment around the Mediterranean Sea and show sedimentation/incision phases that match the 100 ka glacial/interglacial cycles. The mean rate of river incision deduced from the established chronology for the Middle and Late Pleistocene period, 76 ± 7 m.Ma−1, shows adjustments to a moderate uplifting dynamic that shaped the main topographical features seen today in the landscape of the Ardèche Gorge. The spatially reconstructed alluvial features provide a palaeogeographic framework that can be used directly as a chronological and topographical constraint for archaeological research in the Ardèche catchment.

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Fichiers liés : GENUITE ET AL 2022 QSR.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Jean-Philippe GalanaudCéline Genty-VermorelMarie-Thérèse BarrellierFrançois BeckerViolaine JabbourSophie BlaiseAlessandra Bura-RivièreAlexa ComteClaire GrangeHerve GuenneguezMario MaufusPierre OuvryCécile RichaudCarole RollandJeannot SchmidtMarie-Antoinette Pietri-SevestreFrançois VerrièreJean-Luc BossonOlivier PichotMario MaufusHervé GuenneguezPierre OuvryAnna Di MaioJeannot SchmidtJean-Philippe GalanaudAlessandra Bura-RivièreFrancis CouturaudMarc Danguy Des DesertsClaire GrangePatrick MismettiMarie-Thérèse BarrellierDamien LaneelleBéatrice TerriatAudrey StansalMyriam MartinConstant QuashieMickaël BonaldiPatrick LanoyeFrancine Ponchaux-CrépinToufek BerremiliSanthi Samy-ModeliarAzeddine AddalaLuc ToffinBruno RouquetMaïlys Michot-CasbasGuillaume LacazePierre-Marie RoyCécile DurantAnne-Laure Baldassini-EsquisAlain CazanaveDamien RouvièreHélène SkolkaTewfik SalemJean-Michel MonsallierBenoit RogerThien-Quang TraMutendi KalolwaAntoine DiardMarc LambertMebarka TaiarCéline GaudoutSylvain AnceyChristine Jurus
• Organismes : University of Toronto Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Département de Médécine Vasculaire [CHU Caen] Faculté de médecine [Genève] INNOTHERA Centre Hospitalier Universitaire [CHU Grenoble] Service de Médecine Vasculaire [CHU Toulouse] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Centre Hospitalier Lyon Sud [CHU - HCL] Clinique Mégival Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Clinique Mégival Centre Hospitalier Universitaire [CHU Grenoble] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Pôle Urgences [CHU Clermont-Ferrand] CHU Amiens-Picardie CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 INNOTHERA Modélisation et Évaluation des données complexes en Santé Publique Clinique de Médecine Vasculaire Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Clinique Mégival Laboratoire de Psychologie Sociale et Cognitive University of Toronto Service de Médecine Vasculaire [CHU Toulouse] Centre Hospitalier Régional Universitaire de Brest Hôpital d'Instruction des Armées Clermont Tonnerre Centre Hospitalier Lyon Sud [CHU - HCL] Santé Ingénierie Biologie Saint-Etienne Département de Médécine Vasculaire [CHU Caen] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Dijon
• Publié dans The Lancet Haematology le 16/05/2017

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Résumé : Background: The optimal strength of compression needed to prevent post-thrombotic syndrome (PTS) after a proximal deep vein thrombosis (DVT) is debated. We aimed to assess whether 25 mm Hg elastic compression stockings (ECS) are non-inferior to 35 mm Hg ECS in preventing PTS after a DVT. Methods: In this multicentre, double-blind, non-inferiority, randomised controlled trial, we enrolled adults (≥18 years) with a first ipsilateral proximal DVT attending 46 French vascular medicine hospital departments or private practices. Participants were randomly allocated (1:1, stratified by centre, age, and sex; with varying block sizes of two and four) to wear 25 mm Hg or 35 mm Hg ECS for 2 years. The primary outcome was the cumulative rate of PTS 2 years after inclusion, defined by a Villalta scale (≥5). Efficacy was assessed by intention-to-treat and in eligible participants who had complete primary outcome data. A per-protocol analysis was also conducted among compliant patients as a secondary outcome measure. Safety was assessed in all participants who used ECS at least once, and for which we have at least some tolerance information during follow-up. The margin for non-inferiority was 12·5%. This study is registered with ClinicalTrials.gov, NCT01578122, and has been completed. Findings: Between June 28, 2012, and July 21, 2017, we enrolled 341 eligible participants who consented to randomisation. 233 (68%) were men and median age was 59 years (IQR 45-70). Collection of ethnicity and race as a routine research variable is not authorised in France. Median follow-up was 735 days (IQR 721-760). 249 (73%) had complete data at 2 years. For the primary analysis, 40 (31%) of 129 participants with complete data in the 25 mm Hg ECS group and 40 (33%) of 120 in the 35 mm Hg group had PTS (absolute difference -2·3% [90% CI -12·1 to 7·4], pnon-inferiority=0·0062; relative risk 0·93, 95% CI 0·65 to 1·33). Results remained similar after imputation of missing data in patients we were authorised to do so: the cumulative proportion of PTS was 45 (29%) of 154 in the 25 mm Hg ECS group versus 52 (35%) of 148 in the 35 mm Hg ECS group (relative risk 0·83, 95% CI 0·60 to 1·16). Absolute difference was -5·9%, (90% CI -14·7 to 2·9), p=0·0003 for non-inferiority. Adherence was optimal (>80% and modified GIRERD score of 0-2) for 75 (51%) of 146 patients assigned to 25 mm Hg ECS and for 56 (42%) of 134 patients assigned to 35 mm Hg ECS (p=0·11). Regarding major adverse events related to ECS, there were no between-group differences in rates of deep vein thrombosis (0 vs 1 [0·6%]), ipsilateral leg ulcer (0 vs 1 [0·6%]), infection (0 vs 0), or death (0 vs 0) between the 169 patients evaluated in the 25 mm Hg ECS group and the 159 patients in the 35 mm Hg ECS group. Two (1%) of 328 patients who ever wore ESC developed ECS-related serious adverse events, one distal DVT and one leg ulcer (both in the 35 mm Hg ECS group). In the 25 mm Hg group, 6 patients died, 14 had a venous thromboembolic recurrence (proximal DVT or pulmonary embolism), and 7 had a major bleed. In the 35 mm Hg group, 5 patients died, 10 had a venous thromboembolic recurrence (proximal DVT or pulmonary embolism), and 6 had a major bleed. Interpretation: Although we did not reach the prespecified sample size, our results suggest that 25 mm Hg ECS are non-inferior to 35 mm Hg ECS in preventing PTS. Larger more powerful studies are needed.

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Fichiers liés : Galanaud2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Luis Molinos-AlbertValerie LorinValérie MonceauxSylvie OrrAsma EssatJérémy DuflooOlivier SchwartzChristine RouziouxLaurence MeyerLaurent HocquelouxAsier Sáez-CiriónHugo MouquetAnrs Visconti Study GroupThierry PrazuckBarbara De DieuleveultFirouzé Bani-SadrMaxime HentzienJean-Luc BergerIsabelle KmiecGilles PichancourtSafa NasriGilles HittingerVéronique LambryAnne-Cécile BeaueyGilles PialouxChristia PalaciosMartin SiguierAnne AddaJane FoucoinLaurence WeissMarina KarmochkineMohamed MeghadechaMagali PtakDominique Salmon-CéronPhilippe BlancheMarie-Pierre PiétriJean-Michel MolinaOlivier TauleraCaroline Lascoux-CombeDiane PonscarmeJeannine Delgado BertautDjamila MakhloufiMatthieu GodinotValérie ArtizzuYazdan YazdanpanahSophie MatheronCindy GodardZélie JuliaLouis BernardFrédéric BastidesOlivier BourgaultChristine JacometEmilie GoncalvesAgnès MeybeckThomas HuleuxPauline CornavinYasmine DebabDavid ThéronPatrick MiailhesLaurent CotteSophie PailhesStanislas OgoudjobiJean Paul ViardMarie-Josée DulucqLoïc BodardFrancoise ChuraquiThomas GuimardLaetitia Laine
• Organismes : Immunologie humorale - Humoral Immunology Immunologie humorale - Humoral Immunology HIV, Inflammation et persistances virales - HIV, Inflammation and viral Persistences Centre de recherche en épidémiologie et santé des populations Centre de recherche en épidémiologie et santé des populations Virus et Immunité - Virus and immunity Virus et Immunité - Virus and immunity Service de Microbiologie Clinique [Paris] Centre de recherche en épidémiologie et santé des populations La Source Hospital-CHR HIV, Inflammation et persistances virales - HIV, Inflammation and viral Persistences Immunologie humorale - Humoral Immunology Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Henri Duffaut (Avignon) Centre Hospitalier Henri Duffaut (Avignon) CHI de Toulon CHI de Toulon CHI de Toulon CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Hôpital Bretonneau Hôpital Bretonneau CHU Gabriel Montpied [Clermont-Ferrand] CHU Gabriel Montpied [Clermont-Ferrand] Centre Hospitalier Gustave Dron [Tourcoing] Centre Hospitalier Gustave Dron [Tourcoing] Centre Hospitalier Gustave Dron [Tourcoing] Hôpital Charles Nicolle [Rouen] Hôpital Charles Nicolle [Rouen] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital Hôtel-Dieu [Paris] Hôpital Hôtel-Dieu [Paris] Institut mutualiste Monsouris Institut mutualiste Monsouris Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon
• Publié dans Nature Communications le 23/10/2020

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Résumé : HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers. Global multivariate analyses combining clinico-virological and humoral immune data reveal distinct profiles in post-treatment controllers experiencing transient viremic episodes off therapy compared to those stably aviremic. Virally-exposed post-treatment controllers display stronger HIV-1 humoral responses, and develop more frequently Env-specific memory B cells and cross-neutralizing antibodies. Both are linked to short viremic exposures, which are also accompanied by an increase in blood atypical memory B cells and activated subsets of circulating follicular helper T cells. Still, most humoral immune variables only correlate with Th2-like circulating follicular helper T cells. Thus, post-treatment controllers form a heterogeneous group with two distinct viral behaviours and associated immune signatures. Post-treatment controllers stably aviremic present “silent” humoral profiles, while those virally-exposed develop functionally robust HIV-specific B-cell and antibody responses, which may participate in controlling infection.

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Fichiers liés : s41467-022-29511-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Xiaojun LiWigneron J.-P.Frédéric FrappartGabrielle De LannoyLei FanTianjie ZhaoLun GaoShengli TaoHongliang MaZhiqing PengXiangzhuo LiuHuan WangMengjia WangChristophe MoisyPhilippe Ciais
• Organismes : Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Department of Earth and Environmental Sciences [Leuven] Southwest University [Chongqing] Chinese Academy of Sciences [Beijing] University of Illinois at Urbana-Champaign [Urbana] Peking University [Beijing] Wuhan University [China] Chinese Academy of Sciences [Beijing] Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Beijing Normal University Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette]
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : ESA's Soil Moisture Ocean Salinity (SMOS, since 2009) and NASA's Soil Moisture Active Passive (SMAP, since 2015) are the only two space-borne L-band radiometer missions currently in orbit, which provide key information on global surface soil moisture (SM) and vegetation water content (via the vegetation optical depth, VOD). However, to date very few studies considered merging SMOS and SMAP for both SM and VOD retrievals simultaneously. This study presents the first global long-term and continuous SM and L-band VOD (L-VOD) dataset retrieved after merging the SMOS and SMAP brightness temperature (TB) observations, called the SMOS-SMAP-INRAE-BORDEAUX or SMOSMAP-IB product. We first developed a fitted SMOS TB dataset at a fixed incidence angle of 40°, and next applied a monthly linear rescaling of SMAP TB to SMOS TB for each polarization to produce a merged SMOS/SMAP TB (θ = 40°) dataset. The retrievals were then based on a mono-angular retrieval algorithm sharing a similar forward model with the SMOS-IC and the official SMOS retrieval algorithms. Results showed that the inter-calibration approach we used here could effectively remove the bias between the SMAP TB and fitted SMOS TB, with bias values reduced to 0.01 K (−0.02 K) compared to 3.45 K (1.65 K) for V (H) polarization before inter-calibration. The SMOSMAP-IB SM and L-VOD retrievals based on this new inter-calibrated SMOS/SMAP TB led to metrics that were equally good or better than those of other products (i.e., ESA CCI, SMOS-IC and the official SMAP products). When considering only long duration products, SMOSMAP-IB SM retrievals exhibited (i) the highest overall median R value of 0.72 with in-situ data from ISMN (International Soil Moisture Network) during 2013–2018, followed by SMOS-IC (R = 0.68) and CCI (R = 0.67), and (ii) the same smallest ubRMSD values as CCI (ubRMSD = 0.057 m3/m3 vs 0.061 m3/m3 for SMOS-IC). L-VOD retrievals from SMOSMAP-IB were found to have comparable spatial and temporal skills to SMOS-IC. Spatially, they both correlated well with aboveground biomass (R = 0.87), and temporally, they both showed a good representation of the short vegetation NDVI signal and of the forest area loss in the Brazilian Amazon from 2011 to 2019. Developing SMOSMAP-IB is a step forward towards building a time-continuous L-band SM and VOD products in response to the possible failure of one of the SMOS or SMAP sensors in the future.

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