Philippe JEAN-PIERRE

---

• Type de publi. : Article dans une revue
• Date de publi. : 25/04/2023
• Auteurs : Amandine BeryOlivier EtienneLaura MoutonSofiane MokraniChristine Granotier-BeckersLaurent GauthierJustyne Feat-VetelThierry KortulewskiElodie PérèsChantal DesmazePhilippe LestaevelVilma BarrocaAntony LaugerayFawzi BoumezbeurVincent AbramovskiStéphane MortaudArnaud MenuetDenis Le BihanJean-Pierre De VillartayFrançois D Boussin
• Organismes : Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Stabilité génétique, cellules souches et radiations Bureau d'analyse et de suivi des expositions professionnelles Stabilité génétique, cellules souches et radiations Immunologie et Neurogénétique Expérimentales et Moléculaires Service NEUROSPIN Imagine - Institut des maladies génétiques (IHU) Immunologie et Neurogénétique Expérimentales et Moléculaires Immunologie et Neurogénétique Expérimentales et Moléculaires Service NEUROSPIN Imagine - Institut des maladies génétiques (IHU) Stabilité génétique, cellules souches et radiations
• Publié dans Cell Reports le 30/10/2020

---

Résumé : XLF/Cernunnos is a component of the ligation complex used in classical non-homologous end-joining (cNHEJ), a major DNA double-strand break (DSB) repair pathway. We report neurodevelopmental delays and significant behavioral alterations associated with microcephaly in Xlf−/− mice. This phenotype, reminiscent of clinical and neuropathologic features in humans deficient in cNHEJ, is associated with a low level of apoptosis of neural cells and premature neurogenesis, which consists of an early shift of neural progenitors from proliferative to neurogenic divisions during brain development. We show that premature neurogenesis is related to an increase in chromatid breaks affecting mitotic spindle orientation, highlighting a direct link between asymmetric chromosome segregation and asymmetric neurogenic divisions. This study reveals thus that XLF is required for maintaining symmetric proliferative divisions of neural progenitors during brain development and shows that premature neurogenesis may play a major role in neurodevelopmental pathologies caused by NHEJ deficiency and/or genotoxic stress.

---

Fichiers liés : XLF_Cernunnos loss impairs mouse brain development by altering symmetric proliferative divisions of neural progenitors - PIIS2211124723003534.pdf

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 24/04/2023
• Auteurs : Olivier AumontTamara Ben-AriJérôme J. MarietteLaurent JeanneauAymeric SpigaGaëlle LefortPhilippe-E. RocheAlexandre SanterneAndré Estevez-Torres
• Organismes : Nucleus for European Modeling of the Ocean Université de Montpellier Unité de Mathématiques et Informatique Appliquées de Toulouse Géosciences Rennes Laboratoire de Météorologie Dynamique (UMR 8539) Université de Tours Hélium : du fondamental aux applications Aix Marseille Université Laboratoire Jean Perrin

---

Résumé : In the midst of climate change, academic travels - one salient aspect of the carbon footprint of research activities - are at the center of a growing concern. Mitigation options often focus on two dimensions : (i) decreasing the frequency of attendance to conferences and (ii) modal shift in transport. Here, we analyze professional travel in academia from a unique database compiling about 100 000 travels from about 150 research labs across a large array of disciplines and localities in France to detail the structure, patterns and heterogeneity of national and international research travels for research purposes. We estimate the mitigation potential of a series of options encompassing but not limited to institutional options. We show that, if short distance traveling (typically below 1000 km) are largely dominant in number, their relative mitigation potential via modal shift is small (i.e., below 15%). On the other hand, long distance traveling, which is often associated with international collaborations or field work hold a much larger mitigation potential but question the very nature of research activities. We propose ambitious sobriety options to robustly decrease travel-induced GHG emissions in academia and discuss their acceptability in the context of the French public research system.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 24/04/2023
• Auteurs : Fabien ArnaudPierre SabatierJérôme PoulenardCharline Giguet-CovexJean-Philippe JennyErwan MessagerJean-Jacques DelannoyEmmanuel MaletCécile PignolFrançoise AllignolBruno Wilhelm
• Organismes : Environnements, Dynamiques et Territoires de Montagne Institut Ecologie et Environnement - CNRS Ecologie et Environnement Institut national des sciences de l'Univers Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Centre Alpin de Recherche sur les Réseaux Trophiques et Ecosystèmes Limniques Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne Environnements, Dynamiques et Territoires de Montagne

---

Résumé : On April 7th 2022 we learnt the devastating news: our friend and colleague, Bruno Wilhelm, had passed in the mountain while ascending a steep slope in the aim of skiing it. One year after, our group, within which he came and grow to science up to the defence of his PhD thesis in 2012, is still graving. In that context, we are grateful to the organisers of this session for offering us the opportunity of reminding our scientific community the multiple advancements it owes to Bruno.Bruno Wilhelm indeed did a hard and innovative work in the aim of reading the geological record of lakes. He focused himself on the recording of extreme events in lake sediments. In this keynote, we will emphasize how Bruno proposed original ways of characterising what we call “instant deposits”, mostly in the early stages of his too short career. He then particularly worked the question of distinguishing among triggering factors of those “alien” layers that often interbed within lake sediment calm sedimentation. Bruno also proposed a detailed reflexion aiming at quantifying or, at least, ranking the intensity of those triggering events. He hence proposed several ways of assessing past floods intensity. In the same spirit, he explicitly proposed a procedure to assess the “recordability” of past earthquake events within a given lake system, based on historical chronicles. He also led a common reflexion about the ability of lake sediment to record a regional flood signal. After his PhD he committed himself in the scientific animation of the PAGES’ “Floods” working group which led him to coordinate the establishment of a comprehensive database and to participate in the redefinition of a collaborative work to better understand past flood patterns in the iam of anticipating future changes due to global warming.It is undeniable that Bruno Wilhelm had a brilliant and far too short career. However, with this speech we hope that the community will be even more aware about the important legacy he left us.

---

Fichiers liés : Arnaudetal.pdf

---

Source

---

• Type de publi. :
• Date de publi. : 24/04/2023
• Auteurs : Clément MathieuJérôme WassermannM. Adler PierreSébastien PéraltaJean-Louis GalliasL. Hébert RonanPhilippe Bromblet
• Organismes : Laboratoire de mécanique et matériaux du génie civil Laboratoire de mécanique et matériaux du génie civil Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols Laboratoire de Physico-chimie des Polymères et des Interfaces Laboratoire de mécanique et matériaux du génie civil Laboratoire Géosciences et Environnement Cergy Centre Interdisciplinaire de Conservation et Restauration du Patrimoine

---

Résumé : Salt weathering is a main cause of damage in building heritage materials. Despite the large amount of research on this topic, the mechanism of damaging processes remains not fully understood in particular at the pore scale where the salt crystallization and dissolution occur. For this reason, we propose an innovative approach combining damage proxy measurements at pore-scale using Atomic Force Microscopy (AFM), Raman spectrometry and multi-scale numerical modelling, performed during weathering cycles. Imbibition-evaporation cycles are performed on carbonate stones (Savonnières and Saint Maximin limestones) with a 0.1 mol/L sodium sulfate solution at controlled room temperature and relative humidity. The stone samples are especially designed for the measurements at the pore-scale. Cylinder of 1.6 cm diameter and 1.5 cm thickness have been coated with very viscous epoxy resin. Then the two sides of the cylinder have been polished to obtained two free surfaces that allow the fluid circulation in the sample and the measurements. After each weathering cycle, nanoindentation experiments are performed on representative areas of several hundreds of square micrometers in order to monitor the mechanical properties evolution. A force of the µN order is applied in order to stay in the elastic deformation regime. Young modulus values can be then deduced from the slope of the force curves that occurs during the cantilever deflection. With this method, the effect of salt weathering on the mechanical properties of stone minerals is investigated at the pore scale and with no impact of the measurement on the phases structure (reversible indentations). The AFM results are then coupled with chemical Raman mapping to identify the present phases and assign them their mechanical properties. The obtained experimental data are then used in numerical modeling, to generate a numerical Young modulus field with the same properties than the experimental field. Finally, a new medium with higher dimensions will be generated to compare the results with the macro-scale observations on building heritage stones. AFM characterization shows that changes occurred on the topography of the samples between the first and the third alteration cycles. They are of the order of several tens of nanometers and correspond either to salt crystals deposits or in some cases to the loss of material that took place between the second and the third cycle. A decrease of the Young modulus is observed after each cycle that is of the order of 2 GPa between the first and the second cycles. More significant changes are observed after the third cycle especially in some areas where a decrease up to 3 to 4 GPa is estimated.

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 24/04/2023
• Auteurs : Cécile VittoriGuillaume JouveGilles BrocardJean-Philippe GoiranQuentin VitaleLionel DarrasLaurent MattioAlessandro ConfortiChristine OberlinFranck PreusserPierre SabatierEdwige Pons-BranchuCamille GonçalvesBrahimsamba BomouAnne-Lise DevelleAmber GoyonStoil ChapkanskiKevin JacqMaxime Debret
• Organismes : ARCHEORIENT - Environnements et sociétés de l'Orient ancien Exail (iXblue) Histoire et Sources des Mondes antiques ARCHEORIENT - Environnements et sociétés de l'Orient ancien Milieux Environnementaux, Transferts et Interactions dans les hydrosystèmes et les Sols ARCHEORIENT - Environnements et sociétés de l'Orient ancien Exail (iXblue) Istituto per lo studio degli impatti Antropici e Sostenibilità in ambiente marino Archéologie et Archéométrie Albert-Ludwigs-Universität Freiburg = University of Freiburg Environnements, Dynamiques et Territoires de Montagne Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ARCHEORIENT - Environnements et sociétés de l'Orient ancien Université de Lausanne = University of Lausanne Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement ARCHEORIENT - Environnements et sociétés de l'Orient ancien Université Paris 1 Panthéon-Sorbonne - UFR Géographie Identité et Différenciation de l’Espace, de l’Environnement et des Sociétés Morphodynamique Continentale et Côtière Morphodynamique Continentale et Côtière

---

Source

---

• Type de publi. : Communication dans un congrès
• Date de publi. : 24/04/2023
• Auteurs : Guillaume CourtierPierre LaprayRonan AdamSébastien ChangeyJean-Philippe Lauffenburger
• Organismes : Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499 Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499 Institut franco-allemand de recherches de Saint-Louis = French-German Research Institute of Saint-Louis = Deutsch-Französisches Forschungsinstitut Saint-Louis Institut franco-allemand de recherches de Saint-Louis = French-German Research Institute of Saint-Louis = Deutsch-Französisches Forschungsinstitut Saint-Louis Institut de Recherche en Informatique Mathématiques Automatique Signal - IRIMAS - UR 7499

---

Fichiers liés : ieee2023.pdf

---

Source

---

• Type de publi. :
• Date de publi. : 23/04/2023
• Auteurs : Nicolas ChampollionSandrine AnquetinOlivier AumontChristophe BaehrNelly BardetMaialen BarretCédric-Stéphane BationoPascal BellemainCéline BerniOcéane BiabianyAnne BiarnèsNicolas BijonMarie-Paule BonnetMarie BonninMiriam CandelasAlexandre CaronMarceau ChalletMorgane Costes-ThireOlivier DanglesAnne DelaballeLaurence DelattreFrank DelbartA. DezetterVincent EchevinMarie-Alice FoujolsNicolas GratiotCathy GrevesseBertrand GoldmanDamien GuillaudBenoit HingrayFrançoise ImmelSerge JanicotJérémie KleinLaure LaffontAnne-Sophie LoisonFabien MalbetOdin MarcFlorence MichauIsabelle Michaud-SoretEmmanuel MignotLouise MimeauLois MonnierJulien MontillaudVirginie MournetasFlorence Nozay-MauriceG. PanthouElodie PetitdidierNathalie PhilipponSébastien PinelGuillaume PitonMariline PoupaudCharlotte RecapetVéronique RiffaultGeraldine SarretClaudia Teran-EscobarLiselotte TinelBernard TourancheauAurélie Verney-CarronJean-Philippe Vidal
• Organismes : Institut des Géosciences de l’Environnement Nucleus for European Modeling of the Ocean Centre d’Ecologie Fonctionnelle et Evolutive Processus et interactions de fine échelle océanique Institut Pierre-Simon-Laplace Océan et variabilité du climat Institut de Planétologie et d'Astrophysique de Grenoble RiverLy - Fonctionnement des hydrosystèmes Centre for Energy and Environment Centre for Energy and Environment RiverLy - Fonctionnement des hydrosystèmes

---

Résumé : A growing portion of scientists realized the need to not only alert about climate change, but also change their professional practices. A range of tools have emerged to promote more sustainable activities, yet many scientists struggle to go beyond simple awareness-raising to create concrete transition actions. This study proposed the use of a new game-based transition support system called " Ma Terre en 180 Minutes ", which is, to our knowledge, the first tool developed by and for the academic community. It has been designed to build scenarios of greenhouse gases (GHG) emissions reduction in the academic community, and present its deployment during the year 2021, including six hundred participants from 9 countries and 50 cities.

---

Fichiers liés : EGU23-6356-print.pdf

---

Source

---

• Type de publi. :
• Date de publi. : 23/04/2023
• Auteurs : Daniela Rodrigues-BrazLinxin ZhuEmmanuelle GélizéJean-Pierre ClarinXavier ChatagnonPhilippe RampignonJean-Louis BourgesFrancine Behar-CohenMin Zhao
• Organismes : Centre de Recherche des Cordeliers

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 22/04/2023
• Auteurs : T. NovaisSoraya QassemiPhilippe CestacCécile MccambridgeHélène VillarsAudrey ZuerasBertrand DécaudinM. DambrineD. Huvent-GrelleJ. RocheS. SchoenenburgD. FedericoA. C. NierPierre Krolak-SalmonChristelle Mouchoux
• Organismes : Research on Healthcare Performance Hôpital des Charpennes [CHU - HCL] Institut du Viellissement [HCL Lyon] Réseau d’Enseignement et d’innovation pour la Pharmacie d’Officine Equipe AGING (CERPOP) Pôle pharmacie [CHU Toulouse] Pôle pharmacie [CHU Toulouse] Equipe AGING (CERPOP) Pôle Gériatrie [CHU Toulouse] Pôle Gériatrie [CHU Toulouse] Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 Département de Pharmacologie Médicale [Lille] Pôle de gérontologie [CHRU de Lille] Pôle de gérontologie [CHRU de Lille] Pôle de gérontologie [CHRU de Lille] Centre Mémoire Ressources et Recherche [Lyon] Institut du Viellissement [HCL Lyon] Institut du Viellissement [HCL Lyon] Centre Mémoire Ressources et Recherche [Lyon] Institut du Viellissement [HCL Lyon] Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
• Publié dans Contemporary Clinical Trials Communications le 31/10/2020

---

Résumé : Background: Psychosocial interventions for caregivers of patients with Alzheimer disease and relative dementias (ADRD) reported a caregiver burden improvement. Multicomponent intervention integrating pharmaceutical care has not yet been evaluated while ADRD patients and their caregivers are exposed to high risk of drug-related problems. The PHARMAID study aimed to assess the impact of personalized pharmaceutical care integrated to a psychosocial program on the burden of ADRD caregivers at 18 months. Methods: The PHARMAID RCT was conducted between September 2016 and June 2020 [ClinicalTrials.gov: NCT02802371]. PHARMAID study planned to enroll 240 dyads, i.e. ADRD patients and caregivers, whose inclusion criteria were: outpatient with mild or major neurocognitive disorders due to ADRD, living at home, receiving support from a family caregiver. Three parallel groups compared a control group with two interventional groups: psychosocial intervention and integrated pharmaceutical care at a psychosocial intervention. The main outcome was the caregiver burden assessed by the Zarit Burden Index (ZBI, score range 0–88) at 18 months. Results: Overall, 77 dyads were included (32% of the expected sample size). At 18 months, the mean ZBI scores were 36.7 ± 16.8 in the control group, 30.3 ± 16.3 for the group with psychosocial intervention, and 28.8 ± 14.1 in group with integrated pharmaceutical care at psychosocial intervention. No significant difference was demonstrated between the three groups (p = 0.326). Conclusions: The findings suggest that PHARMAID program had no significant impact on caregiver burden at 18 months. Several limitations have been highlighted and discussed by the authors in order to formulate recommendations for further research.

---

Fichiers liés : 1-s2.0-S2451865423000923-main.pdf

---

Source

---

• Type de publi. : Article dans une revue
• Date de publi. : 20/04/2023
• Auteurs : Angelica LauritaLiang ZhuPierre-Etienne CabelguenJérémie AuvergniotDominique GuyomardP. MoreauNicolas Dupré
• Organismes : Institut des Matériaux de Nantes Jean Rouxel Umicore Rechargeable Battery Materials Umicore Rechargeable Battery Materials Umicore Rechargeable Battery Materials Institut des Matériaux de Nantes Jean Rouxel Institut des Matériaux de Nantes Jean Rouxel Institut des Matériaux de Nantes Jean Rouxel
• Publié dans Chemical Communications le 29/10/2020

---

Résumé : Li-7 MAS NMR quantification of lithiated species at the surface of aged NMC811 industrial powders and slurries shows that the electrode preparation process exacerbates Li extraction. A combination of Li-7 MAS NMR and XPS suggest a new reaction for the PVdF binder degradation, involving in fact Li2O as the reagent and the formation of LiF.

---

Fichiers liés : Residual Li2O -no template.pdf

---

Source