Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Luis Felipe ReyesSrinivas MurthyEsteban Garcia-GalloLaura MersonElsa Ibáñez-PradaJordi RelloYuli FuentesIgnacio Martin-LoechesFernando BozzaSara DuqueFabio TacconeRobert FowlerChristiana KartsonakiBronner GonçalvesBarbara Wanjiru CitarellaDiptesh AryalErlina BurhanMatthew CummingsChristelle DelmasRodrigo DiazClaudia Figueiredo-MelloMadiha HashmiPrasan Kumar PandaMiguel Pedrera JiménezDiego Fernando Bautista RinconDavid ThomsonAlistair NicholJohn MarshallPiero OlliaroAli AbbasSheryl Ann AbdukahilRyuzo AbeLaurent AbelLara AbsilSubhash AcharyaAndrew AckerDiana AdriãoSaleh Al AgeelShakeel AhmedKate AinscoughTharwat AisaAli Ait HssainYounes Ait TamlihatTakako AkimotoErnita AkmalEman Al QasimRazi AlalqamTala Al-DabbousSenthilkumar AlegesanCynthia AlegreMarta AlessiBeatrice AlexKévin AlexandreAbdulrahman Al-FaresHuda AlfoudriImran AliNaseem Ali ShahKazali Enagnon AlidjnouJeffrey AliudinQabas AlkhafajeeClotilde AllavenaNathalie AllouAneela AltafJoão AlvesJoão Melo AlvesRita AlvesJoana Alves CabritaMaria AmaralPhoebe AmpawRoberto AndiniClaire AndréjakAndrea AnghebenFrançois AngoulvantSéverine AnsartMassimo AntonelliCarlos Alexandre Antunes de BritoArdiyan ApriyanaYaseen ArabiIrene AragaoCarolline AraujoAntonio ArcadipanePatrick ArchambaultLukas ArenzJean-Benoît ArletChristel Arnold-DayLovkesh AroraRakesh AroraElise Artaud-MacariDiptesh AryalAngel AsensioNamra AsifMohammad AsimJean Baptiste AssieAnika AtiqueA. AttanyakeJohann AuchabieHugues AumaitreAdrien AuvetLaurène AzemarCecile AzoulayBenjamin BachDelphine BacheletClaudine BadrNadia BaigJ. 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UdayangaAndrew UdyRoman UllrichAlberto UribeAsad UsmanTimothy UyekiCristinava VajdovicsLuís Val-FloresAmélie ValranStijn van de VeldeMarcel van den BergeJob van der PalenPaul van der ValkNicky van der VekensPeter van der VoortSylvie van der WerfLaura van GulikJarne van HattemCarolien van NettenIlonka van VeenNoémie VanelHenk VanoverscheldePooja VargheseCharline VauchyAurélie VeislingerSebastian VenckenSara VenturaAnnelies VerbonJames VickersJosé Ernesto VidalCésar VieiraDeepak VijayanJoy Ann VillanuevaJudit VillarPierre-Marc VilleneuveAndrea VilloldoBenoit VisseauxHannah VisserChiara VitielloHarald VonkemanFanny VuottoWan Fadzlina Wan Muhd ShukeriChih-Hsien WangSteve WebbJia WeiKatharina WeilSanne WesseliusT. Eoin WestMurray WhamBryan WhelanNicole WhitePaul Henri WickyAurélie WiedemannSurya Otto WijayaKeith WilleSuzette WillemsVirginie WilliamsEvert-Jan WilsNg Wing YiuCalvin WongIoannis XynogalasMasaki YamazakiYazdan YazdanpanahCécile YelnikStephanie YerkovichToshiki YokoyamaHodane YonisObada YousifSaptadi YuliartoAkram ZaaqoqMarion ZabbeMaram ZahranMaria ZambonAlberto ZanellaHiba ZayyadAlexander ZoufalyDavid Zucman
• Organismes : Pandemic Sciences Institute, University of Oxford, Oxford Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou] Institut de recherche en santé, environnement et travail
• Publié dans Critical Care le 31/10/2020

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Résumé : Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs).Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support.Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83-7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97-2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14-1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25-1.30]).Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable.

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Fichiers liés : s13054-022-04155-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : David MalkaNicolas GirardDavid M SmadjaChristine ChevreauStéphane CulineAnne LesurRoman RouzierFrançois RozetJean-Philippe SpanoJean-Yves Blay
• Organismes : Dynamique des cellules tumorales Epidémiologie, Systèmes d'Information, Modélisation
• Publié dans Bulletin du Cancer le 01/11/2020

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Fichiers liés : [Prophylaxis and management of cancer-associated thrombosis Practical issues about anticoagulant use]..pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Kim GénuitePierre VoinchetJean-Jacques DelannoyJean-Jacques BahainJulien MonneyJudicaël ArnaudLaurent BruxellesMarie-Hélène MoncelAnne PhilippeEdwige Pons-BranchuAndré RevilMaïlys RichardStéphane Jaillet
• Organismes : Environnements, Dynamiques et Territoires de Montagne Histoire naturelle de l'Homme préhistorique Environnements, Dynamiques et Territoires de Montagne Histoire naturelle de l'Homme préhistorique Muséum national d'Histoire naturelle Environnements, Dynamiques et Territoires de Montagne Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés School of Geography, Archaeology and Environmental Studies [Johannesburg] Histoire naturelle de l'Homme préhistorique Laboratoire de Mathématiques Jean Leray Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Institut des Sciences de la Terre Environnements, Dynamiques et Territoires de Montagne Centro Nacional de Investigación sobre la Evolución Humana Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Géochrononologie Traceurs Archéométrie Eberhard Karls Universität Tübingen = University of Tübingen Centre de recherche francais de Jérusalem Environnements, Dynamiques et Territoires de Montagne
• Publié dans Quaternary Science Reviews le 27/10/2020

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Résumé : Most archaeological and palaeo-environmental archives are preserved in specific environments (buried sediments, rock shelters, cave environments). Hence, the information we can obtain is usually incomplete, and lacking spatial and morphological significance. Studying landscape evolution can help us to understand the location and distribution of past societies and their relation to Quaternary environments. In the Ardèche Valley, most Middle and Late Palaeolithic sites are preserved in caves and rock-shelters and in rare cases in fluvial sediments. Here we apply an integrated geomorphological approach to the study of the evolution of the Ardèche Valley combining multi-method dating, geomorphological mapping and surveys of cave and fluvial formations. We review chronological results obtained through multi-method dating (electron spin resonance (ESR), infrared stimulated luminescence (IRSL), uranium-series (U-series), combined electron spin resonance/uranium-series (ESR/U-series)) on cave and riverine objects and combine them with topographic and stratigraphic observations in an integrated Bayesian hierarchical model. The results are in agreement with those obtained from other rivers in mountainous environment around the Mediterranean Sea and show sedimentation/incision phases that match the 100 ka glacial/interglacial cycles. The mean rate of river incision deduced from the established chronology for the Middle and Late Pleistocene period, 76 ± 7 m.Ma−1, shows adjustments to a moderate uplifting dynamic that shaped the main topographical features seen today in the landscape of the Ardèche Gorge. The spatially reconstructed alluvial features provide a palaeogeographic framework that can be used directly as a chronological and topographical constraint for archaeological research in the Ardèche catchment.

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Fichiers liés : GENUITE ET AL 2022 QSR.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Jean-Philippe GalanaudCéline Genty-VermorelMarie-Thérèse BarrellierFrançois BeckerViolaine JabbourSophie BlaiseAlessandra Bura-RivièreAlexa ComteClaire GrangeHerve GuenneguezMario MaufusPierre OuvryCécile RichaudCarole RollandJeannot SchmidtMarie-Antoinette Pietri-SevestreFrançois VerrièreJean-Luc BossonOlivier PichotMario MaufusHervé GuenneguezPierre OuvryAnna Di MaioJeannot SchmidtJean-Philippe GalanaudAlessandra Bura-RivièreFrancis CouturaudMarc Danguy Des DesertsClaire GrangePatrick MismettiMarie-Thérèse BarrellierDamien LaneelleBéatrice TerriatAudrey StansalMyriam MartinConstant QuashieMickaël BonaldiPatrick LanoyeFrancine Ponchaux-CrépinToufek BerremiliSanthi Samy-ModeliarAzeddine AddalaLuc ToffinBruno RouquetMaïlys Michot-CasbasGuillaume LacazePierre-Marie RoyCécile DurantAnne-Laure Baldassini-EsquisAlain CazanaveDamien RouvièreHélène SkolkaTewfik SalemJean-Michel MonsallierBenoit RogerThien-Quang TraMutendi KalolwaAntoine DiardMarc LambertMebarka TaiarCéline GaudoutSylvain AnceyChristine Jurus
• Organismes : University of Toronto Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Département de Médécine Vasculaire [CHU Caen] Faculté de médecine [Genève] INNOTHERA Centre Hospitalier Universitaire [CHU Grenoble] Service de Médecine Vasculaire [CHU Toulouse] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Centre Hospitalier Lyon Sud [CHU - HCL] Clinique Mégival Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Clinique Mégival Centre Hospitalier Universitaire [CHU Grenoble] Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 Pôle Urgences [CHU Clermont-Ferrand] CHU Amiens-Picardie CHirurgie, IMagerie et REgénération tissulaire de l’extrémité céphalique - Caractérisation morphologique et fonctionnelle - UR UPJV 7516 INNOTHERA Modélisation et Évaluation des données complexes en Santé Publique Clinique de Médecine Vasculaire Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] Clinique Mégival Laboratoire de Psychologie Sociale et Cognitive University of Toronto Service de Médecine Vasculaire [CHU Toulouse] Centre Hospitalier Régional Universitaire de Brest Hôpital d'Instruction des Armées Clermont Tonnerre Centre Hospitalier Lyon Sud [CHU - HCL] Santé Ingénierie Biologie Saint-Etienne Département de Médécine Vasculaire [CHU Caen] CHU Caen Normandie – Centre Hospitalier Universitaire de Caen Normandie CHU Dijon
• Publié dans The Lancet Haematology le 16/05/2017

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Résumé : Background: The optimal strength of compression needed to prevent post-thrombotic syndrome (PTS) after a proximal deep vein thrombosis (DVT) is debated. We aimed to assess whether 25 mm Hg elastic compression stockings (ECS) are non-inferior to 35 mm Hg ECS in preventing PTS after a DVT. Methods: In this multicentre, double-blind, non-inferiority, randomised controlled trial, we enrolled adults (≥18 years) with a first ipsilateral proximal DVT attending 46 French vascular medicine hospital departments or private practices. Participants were randomly allocated (1:1, stratified by centre, age, and sex; with varying block sizes of two and four) to wear 25 mm Hg or 35 mm Hg ECS for 2 years. The primary outcome was the cumulative rate of PTS 2 years after inclusion, defined by a Villalta scale (≥5). Efficacy was assessed by intention-to-treat and in eligible participants who had complete primary outcome data. A per-protocol analysis was also conducted among compliant patients as a secondary outcome measure. Safety was assessed in all participants who used ECS at least once, and for which we have at least some tolerance information during follow-up. The margin for non-inferiority was 12·5%. This study is registered with ClinicalTrials.gov, NCT01578122, and has been completed. Findings: Between June 28, 2012, and July 21, 2017, we enrolled 341 eligible participants who consented to randomisation. 233 (68%) were men and median age was 59 years (IQR 45-70). Collection of ethnicity and race as a routine research variable is not authorised in France. Median follow-up was 735 days (IQR 721-760). 249 (73%) had complete data at 2 years. For the primary analysis, 40 (31%) of 129 participants with complete data in the 25 mm Hg ECS group and 40 (33%) of 120 in the 35 mm Hg group had PTS (absolute difference -2·3% [90% CI -12·1 to 7·4], pnon-inferiority=0·0062; relative risk 0·93, 95% CI 0·65 to 1·33). Results remained similar after imputation of missing data in patients we were authorised to do so: the cumulative proportion of PTS was 45 (29%) of 154 in the 25 mm Hg ECS group versus 52 (35%) of 148 in the 35 mm Hg ECS group (relative risk 0·83, 95% CI 0·60 to 1·16). Absolute difference was -5·9%, (90% CI -14·7 to 2·9), p=0·0003 for non-inferiority. Adherence was optimal (>80% and modified GIRERD score of 0-2) for 75 (51%) of 146 patients assigned to 25 mm Hg ECS and for 56 (42%) of 134 patients assigned to 35 mm Hg ECS (p=0·11). Regarding major adverse events related to ECS, there were no between-group differences in rates of deep vein thrombosis (0 vs 1 [0·6%]), ipsilateral leg ulcer (0 vs 1 [0·6%]), infection (0 vs 0), or death (0 vs 0) between the 169 patients evaluated in the 25 mm Hg ECS group and the 159 patients in the 35 mm Hg ECS group. Two (1%) of 328 patients who ever wore ESC developed ECS-related serious adverse events, one distal DVT and one leg ulcer (both in the 35 mm Hg ECS group). In the 25 mm Hg group, 6 patients died, 14 had a venous thromboembolic recurrence (proximal DVT or pulmonary embolism), and 7 had a major bleed. In the 35 mm Hg group, 5 patients died, 10 had a venous thromboembolic recurrence (proximal DVT or pulmonary embolism), and 6 had a major bleed. Interpretation: Although we did not reach the prespecified sample size, our results suggest that 25 mm Hg ECS are non-inferior to 35 mm Hg ECS in preventing PTS. Larger more powerful studies are needed.

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Fichiers liés : Galanaud2022.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Luis Molinos-AlbertValerie LorinValérie MonceauxSylvie OrrAsma EssatJérémy DuflooOlivier SchwartzChristine RouziouxLaurence MeyerLaurent HocquelouxAsier Sáez-CiriónHugo MouquetAnrs Visconti Study GroupThierry PrazuckBarbara De DieuleveultFirouzé Bani-SadrMaxime HentzienJean-Luc BergerIsabelle KmiecGilles PichancourtSafa NasriGilles HittingerVéronique LambryAnne-Cécile BeaueyGilles PialouxChristia PalaciosMartin SiguierAnne AddaJane FoucoinLaurence WeissMarina KarmochkineMohamed MeghadechaMagali PtakDominique Salmon-CéronPhilippe BlancheMarie-Pierre PiétriJean-Michel MolinaOlivier TauleraCaroline Lascoux-CombeDiane PonscarmeJeannine Delgado BertautDjamila MakhloufiMatthieu GodinotValérie ArtizzuYazdan YazdanpanahSophie MatheronCindy GodardZélie JuliaLouis BernardFrédéric BastidesOlivier BourgaultChristine JacometEmilie GoncalvesAgnès MeybeckThomas HuleuxPauline CornavinYasmine DebabDavid ThéronPatrick MiailhesLaurent CotteSophie PailhesStanislas OgoudjobiJean Paul ViardMarie-Josée DulucqLoïc BodardFrancoise ChuraquiThomas GuimardLaetitia Laine
• Organismes : Immunologie humorale - Humoral Immunology Immunologie humorale - Humoral Immunology HIV, Inflammation et persistances virales - HIV, Inflammation and viral Persistences Centre de recherche en épidémiologie et santé des populations Centre de recherche en épidémiologie et santé des populations Virus et Immunité - Virus and immunity Virus et Immunité - Virus and immunity Service de Microbiologie Clinique [Paris] Centre de recherche en épidémiologie et santé des populations La Source Hospital-CHR HIV, Inflammation et persistances virales - HIV, Inflammation and viral Persistences Immunologie humorale - Humoral Immunology Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Hôpital universitaire Robert Debré [Reims] Centre Hospitalier Henri Duffaut (Avignon) Centre Hospitalier Henri Duffaut (Avignon) CHI de Toulon CHI de Toulon CHI de Toulon CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] CHU Tenon [AP-HP] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Hôpital Européen Georges Pompidou [APHP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hôpital Cochin [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hopital Saint-Louis [AP-HP] Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] Hôpital Edouard Herriot [CHU - HCL] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] AP-HP - Hôpital Bichat - Claude Bernard [Paris] Hôpital Bretonneau Hôpital Bretonneau CHU Gabriel Montpied [Clermont-Ferrand] CHU Gabriel Montpied [Clermont-Ferrand] Centre Hospitalier Gustave Dron [Tourcoing] Centre Hospitalier Gustave Dron [Tourcoing] Centre Hospitalier Gustave Dron [Tourcoing] Hôpital Charles Nicolle [Rouen] Hôpital Charles Nicolle [Rouen] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital de la Croix-Rousse [CHU - HCL] Hôpital Hôtel-Dieu [Paris] Hôpital Hôtel-Dieu [Paris] Institut mutualiste Monsouris Institut mutualiste Monsouris Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon
• Publié dans Nature Communications le 23/10/2020

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Résumé : HIV-1 post-treatment controllers are rare individuals controlling HIV-1 infection for years after antiretroviral therapy interruption. Identification of immune correlates of control in post-treatment controllers could aid in designing effective HIV-1 vaccine and remission strategies. Here, we perform comprehensive immunoprofiling of the humoral response to HIV-1 in long-term post-treatment controllers. Global multivariate analyses combining clinico-virological and humoral immune data reveal distinct profiles in post-treatment controllers experiencing transient viremic episodes off therapy compared to those stably aviremic. Virally-exposed post-treatment controllers display stronger HIV-1 humoral responses, and develop more frequently Env-specific memory B cells and cross-neutralizing antibodies. Both are linked to short viremic exposures, which are also accompanied by an increase in blood atypical memory B cells and activated subsets of circulating follicular helper T cells. Still, most humoral immune variables only correlate with Th2-like circulating follicular helper T cells. Thus, post-treatment controllers form a heterogeneous group with two distinct viral behaviours and associated immune signatures. Post-treatment controllers stably aviremic present “silent” humoral profiles, while those virally-exposed develop functionally robust HIV-specific B-cell and antibody responses, which may participate in controlling infection.

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Fichiers liés : s41467-022-29511-1.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Xiaojun LiWigneron J.-P.Frédéric FrappartGabrielle De LannoyLei FanTianjie ZhaoLun GaoShengli TaoHongliang MaZhiqing PengXiangzhuo LiuHuan WangMengjia WangChristophe MoisyPhilippe Ciais
• Organismes : Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Department of Earth and Environmental Sciences [Leuven] Southwest University [Chongqing] Chinese Academy of Sciences [Beijing] University of Illinois at Urbana-Champaign [Urbana] Peking University [Beijing] Wuhan University [China] Chinese Academy of Sciences [Beijing] Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Beijing Normal University Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette]
• Publié dans Remote Sensing of Environment le 28/10/2020

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Résumé : ESA's Soil Moisture Ocean Salinity (SMOS, since 2009) and NASA's Soil Moisture Active Passive (SMAP, since 2015) are the only two space-borne L-band radiometer missions currently in orbit, which provide key information on global surface soil moisture (SM) and vegetation water content (via the vegetation optical depth, VOD). However, to date very few studies considered merging SMOS and SMAP for both SM and VOD retrievals simultaneously. This study presents the first global long-term and continuous SM and L-band VOD (L-VOD) dataset retrieved after merging the SMOS and SMAP brightness temperature (TB) observations, called the SMOS-SMAP-INRAE-BORDEAUX or SMOSMAP-IB product. We first developed a fitted SMOS TB dataset at a fixed incidence angle of 40°, and next applied a monthly linear rescaling of SMAP TB to SMOS TB for each polarization to produce a merged SMOS/SMAP TB (θ = 40°) dataset. The retrievals were then based on a mono-angular retrieval algorithm sharing a similar forward model with the SMOS-IC and the official SMOS retrieval algorithms. Results showed that the inter-calibration approach we used here could effectively remove the bias between the SMAP TB and fitted SMOS TB, with bias values reduced to 0.01 K (−0.02 K) compared to 3.45 K (1.65 K) for V (H) polarization before inter-calibration. The SMOSMAP-IB SM and L-VOD retrievals based on this new inter-calibrated SMOS/SMAP TB led to metrics that were equally good or better than those of other products (i.e., ESA CCI, SMOS-IC and the official SMAP products). When considering only long duration products, SMOSMAP-IB SM retrievals exhibited (i) the highest overall median R value of 0.72 with in-situ data from ISMN (International Soil Moisture Network) during 2013–2018, followed by SMOS-IC (R = 0.68) and CCI (R = 0.67), and (ii) the same smallest ubRMSD values as CCI (ubRMSD = 0.057 m3/m3 vs 0.061 m3/m3 for SMOS-IC). L-VOD retrievals from SMOSMAP-IB were found to have comparable spatial and temporal skills to SMOS-IC. Spatially, they both correlated well with aboveground biomass (R = 0.87), and temporally, they both showed a good representation of the short vegetation NDVI signal and of the forest area loss in the Brazilian Amazon from 2011 to 2019. Developing SMOSMAP-IB is a step forward towards building a time-continuous L-band SM and VOD products in response to the possible failure of one of the SMOS or SMAP sensors in the future.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Jean‐philippe EmpanaIvan LernerMarie-Cécile PerierCatherine GuiboutPatricia JabreKarine BaillyMuriel AndrieuRachel ClimieThomas T van SlotenBenoit VedieDaniela GerominEloi MarijonFrederique ThomasNicolas DanchinPierre BoutouyrieXavier Jouven
• Organismes : Paris-Centre de Recherche Cardiovasculaire
• Publié dans Arteriosclerosis, Thrombosis, and Vascular Biology le 27/10/2020

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Résumé : Background: To examine the association of ultrasensitive cTnI (cardiac troponin I) with incident cardiovascular disease events (CVDs) in the primary prevention setting. Methods: cTnI was analyzed in the baseline plasma (2008–2012) of CVD-free volunteers from the Paris Prospective Study III using a novel ultrasensitive immunoassay (Simoa Troponin-I 2.0 Kit, Quanterix, Lexington) with a limit of detection of 0.013 pg/mL. Incident CVD hospitalizations (coronary heart disease, stroke, cardiac arrhythmias, deep venous thrombosis or pulmonary embolism, heart failure, or arterial aneurysm) were validated by critical review of the hospital records. Hazard ratios were estimated per log-transformed SD increase of cTnI in Cox models using age as the time scale. Results: The study population includes 9503 participants (40% women) aged 59.6 (6.3) years. cTnI was detected in 99.6% of the participants (median value=0.63 pg/mL, interquartile range, 0.39–1.09). After a median follow-up of 8.34 years (interquartile range, 8.0–10.07), 516 participants suffered 612 events. In fully adjusted analysis, higher cTnI (per 1 SD increase of log cTnI) was significantly associated with CVD events combined (hazard ratio, 1.18 [1.08–1.30]). Among all single risk factors, cTnI had the highest discrimination capacity for incident CVD events (C index=0.6349). Adding log cTnI to the SCORE 2 (Systematic Coronary Risk Evaluation) risk improved moderately discriminatory capacity (C index 0.698 versus 0.685; bootstrapped C index difference: 0.0135 [95% CI, 0.0131–0.0138]), and reclassification of the participants (categorical net reclassification index, 0.0628 [95% CI, 0.023–0.102]). Findings were consistent using the US pooled cohort risk equation. Conclusions: Ultrasensitive cTnI is an independent marker of CVD events in the primary prevention setting.

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Edith Le FlochTeresa CosentinoCasper K LarsenFelix BeuschleinMartin ReinckeLaurence AmarGian-Paolo RossiKelly de SousaStéphanie BaronSophie ChantalatBenjamin SaintpierreLivia LenziniArthur FrouinIsabelle Giscos-DouriezMatthis FereyAlaa B AbdellatifTchao MeatchiJean-Philippe EmpanaXavier JouvenChristian GiegerMelanie WaldenbergerAnnette PetersDaniele CusiErika SalviPierre MenetonMathilde TouvierMélanie DeschasauxNathalie Druesne-PecolloSheerazed BoulkrounFabio L Fernandes-RosaJean‐françois DeleuzeXavier JeunemaitreMaria-Christina Zennaro
• Organismes : Centre National de Recherche en Génomique Humaine Institut de Biologie François JACOB Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Ludwig-Maximilians University [Munich] Universität Zürich [Zürich] = University of Zurich Ludwig-Maximilians University [Munich] Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Università degli Studi di Padova = University of Padua Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Université Paris Cité Centre National de Recherche en Génomique Humaine Institut de Biologie François JACOB Institut Cochin Plateforme de genomique Università degli Studi di Padova = University of Padua Centre National de Recherche en Génomique Humaine Institut de Biologie François JACOB Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Helmholtz Zentrum München = German Research Center for Environmental Health German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] Helmholtz Zentrum München = German Research Center for Environmental Health German Center for Cardiovascular Research Helmholtz Zentrum München = German Research Center for Environmental Health German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] German Center for Cardiovascular Research Consiglio Nazionale delle Ricerche [Milano] Fondazione IRCCS Istituto Neurologico "Carlo Besta" Laboratoire d'Informatique Médicale et Ingénierie des Connaissances en e-Santé Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle Nutritional Epidemiology Research Team | Equipe de Recherche en Epidémiologie Nutritionnelle Paris-Centre de Recherche Cardiovasculaire Paris-Centre de Recherche Cardiovasculaire Centre National de Recherche en Génomique Humaine Institut de Biologie François JACOB Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP] Paris-Centre de Recherche Cardiovasculaire Hôpital Européen Georges Pompidou [APHP]
• Publié dans Nature Communications le 23/10/2020

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Résumé : Abstract Primary aldosteronism affects up to 10% of hypertensive patients and is responsible for treatment resistance and increased cardiovascular risk. Here we perform a genome-wide association study in a discovery cohort of 562 cases and 950 controls and identify three main loci on chromosomes 1, 13 and X; associations on chromosome 1 and 13 are replicated in a second cohort and confirmed by a meta-analysis involving 1162 cases and 3296 controls. The association on chromosome 13 is specific to men and stronger in bilateral adrenal hyperplasia than aldosterone producing adenoma. Candidate genes located within the two loci, CASZ1 and RXFP2 , are expressed in human and mouse adrenals in different cell clusters. Their overexpression in adrenocortical cells suppresses mineralocorticoid output under basal and stimulated conditions, without affecting cortisol biosynthesis. Our study identifies the first risk loci for primary aldosteronism and highlights new mechanisms for the development of aldosterone excess.

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Fichiers liés : 41467_2022_Article_32896.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Nicolas MassartVirginie MaximePierre FillatreKeyvan RazaziAlexis FerréPierre MoineFrancois LegayGuillaume VoiriotMarlene AmaraFrancesca SantiSaad NseirStephanie Marque-JuilletRania BounabNicolas BarbarotFabrice BruneelCharles-Edouard LuytTài PhamArthur PavotXavier MonnetChristian RichardAlexandre DemouleMartin DresJulien MayauxAlexandra BeurtonCédric DaubinRichard DescampsAurélie JoretDamien Du CheyronFrédéric PeneJean-Daniel ChicheMathieu JozwiakPaul JaubertGuillaume VoiriotMuriel FartoukhMarion TeulierClarisse BlayauLaetitia BodenesNicolas FerriereJohann AuchabieAnthony Le MeurSylvain PignalThierry MazzoniJean-Pierre QuenotPascal AndreuJean-Baptiste RoudauMarie LabruyèreSaad NseirSébastien PréauJulien PoissyDaniel MathieuSarah BenhamidaRémi PauletNicolas RoucaudMartial ThyraultFlorence DavietSami HraiechGabriel ParzyAude SylvestreSébastien JochmansAnne-Laure BouillandMehran MonchiMarc Danguy Des DésertsQuentin MathaisGwendoline RagerPierre PasquierJean ReignierAmélie SeguinCharlotte GarretEmmanuel CanetJean DellamonicaClément SaccheriRomain LombardiYanis KouchitSophie JacquierArmelle MathonnetMai-Ahn NayIsabelle RungeFrédéric MartinoLaure FlurinAmélie RolleMichel CarlesRémi CoudroyArnaud W. ThilleJean-Pierre FratMaeva RodriguezPascal BeuretAudrey TientcheuArthur VincentFlorian MichelinFabienne TamionDorothée CarpentierDéborah BoyerChristophe GiraultValérie GissotStéphan EhrmannCharlotte Salmon GandonniereDjlali ElaroussiAgathe DelboveYannick FedunJulien HuntzingerEddy LebasGrâce KisokaCéline GrégoireStella MarchettaBernard LambermontLaurent ArgaudThomas BaudryPierre-Jean BertrandAuguste DargentChristophe GuittonNicolas ChudeauMickaël LandaisCédric DarreauAlexis FerreAntoine GrosGuillaume LacaveFabrice BruneelMathilde NeuvilleGuillaume TachonRichard GalloRiad ChelhaArnaud GalboisAnne JallotLudivine Chalumeau LemoineKhaldoun KuteifanValentin PointurierLouise-Marie JandeauxJoy MootienCharles DamoiselBenjamin SztrymfMatthieu SchmidtAlain CombesJuliette ChommelouxCharles Edouard LuytFrédérique SchortgenLeon RuselCamille JungFlorent GobertDamien VimpereLionel LamhautBertrand SauneufLiliane CharrrierJulien CalusIsabelle DesmeulesBenoît PainvinJean-Marc TadieVincent CastelainBaptiste MichardJean-Etienne HerbrechtMathieu BaldaciniNicolas WeissSophie DemeretClémence MaroisBenjamin RohautPierre-Henri MouryAnne-Charlotte SavidaEmmanuel CouadauMathieu SérieNica AlexandruCédric BruelCandice FontaineSonia GarrigouJuliette Courtiade MahlerMaxime LeclercMichel RamakersPierre GarçonNicole MassouLy van VongJuliane SenNolwenn LucasFranck ChemouniAnnabelle StoclinAlexandre AvenelHenri FaureAngélie GentilhommeSylvie RicomePaul AbrahamCéline MonardJulien TextorisThomas RimmeleFlorent MontiniGabriel LejourThierry LazardIsabelle EtienneyYounes KerroumiClaire DupuisMarine BereiziatElisabeth CoupezFrançois ThouyClément HoffmannNicolas DonatAnne ChrismentRose-Marie BlotAntoine KimmounAudrey JacquotMatthieu MatteiBruno LevyRamin RavanLoïc DopeuxJean-Mathias LiteaudonDelphine RouxBrice ReyRadu AnghelDeborah SchenesseVincent GevreyJermy CastaneraPhilippe PetuaBenjamin MadeuxOtto HartmanMichael PiagnerelliAnne JoostenCinderella NoelPatrick BistonThibaut NoelGurvan 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HamadaDiane ZlotnikHélène NougueArmand Mekontso-DessapGuillaume CarteauxKeyvan RazaziNicolas de ProstNicolas MongardonMeriam LamraouiClaire AlessandriQuentin de RouxCharles de RoquetailladeBenjamin ChoustermanAlexandre MebazaaEtienne GayatMarc GarnierEmmanuel PardoChristophe GuttonElise YvinClémence MarcaultÉlie AzoulayMichaël DarmonHafid Ait OufellaGeoffroy HaririTomas UrbinaSandie MazerandNicholas HemingFrancesca SantiPierre MoineDjillali AnnaneAdrien BougléEdris OmarAymeric LancelotEmmanuelle BegotGaétan PlantefeveDamien ContouHervé MentecOlivier PajotStanislas FaguerOlivier CointaultLaurence LavayssiereMarie-Béatrice NogierMatthieu JammeClaire PichereauJan HayonHervé OutinFrançois DépretMaxime CoutrotMaité ChaussardLucie GuillemetPierre GoffinRomain ThounyJulien GuntzLaurent JadotRomain PersichiniVanessa Jean-MichelHugues GeorgesThomas CaulierGaël PradelMarie-Hélène HausermannThi My Hue Nguyen-ValatMichel BoudinaudEmmanuel VivierGaël BourdinChristian PommierMarc VinclairSimon PoignantSandrine MonsWulfran BougouinFranklin BrunaQuentin MaestraggiChristian RothLaurent BitkerFrançois DhelftJustine Bonnet-ChateauMathilde FilippelliTristan Morichau-BeauchantStéphane ThierryCharlotte Le RoyMélanie Saint JouanBruno GoncalvesAurélien MazeraudMatthieu DanielTarek SharsharCyril CadozSébastien GetteGuillaune LouisSophe-Caroline SacleuxMarie-Amélie OrdanAurélie CravoisyMarie ConradGuilhem CourteSébastien GibotYounès BenzidiClaudia CasellaLaurent SerpinJean-Lou SettiMarie-Catherine BesseAnna BourreauJérôme PillotCaroline RiveraCamille VinclairMarie-Aline RobauxChloé AchinoMarie-Charlotte DelignetteTessa MazardFrédéric AubrunBruno BouchetAurélien FrérouLaura MullerCharlotte QuentinSamuel DegoulXavier StihleClaude SumianNicoletta BergeroBernard LanaspreHervé QuintardEve Marie MaizierePierre-Yves EgreteauGuillaume LeloupFlorin BerteauMarjolaine CottrelMarie BouteloupMatthieu JeannotQuentin BlancJulien SaisonIsabelle GeneauRomaric GrenotAbdel OuchikePascal HazeraAnne-Lyse MasseSuela DemiriCorinne VezinetElodie BaronDeborah BenchetritAntoine MonselGrégoire TrebbiaEmmanuelle SchaackRaphaël LepecqMathieu BobetChristophe VinsonneauThibault DekeyserQuentin DelforgeImen RahmaniBérengère VivetJonathan PaillotLucie HierleClaire ChaignatSarah ValetteBenoït HerJennifier BrunetMathieu PageFabienne BoisteAnthony CollinFlorent BavozetAude GarinMohamed DlalaBassem BeilounyAlexandra LavalardSeverine PerezBenoit VeberPierre-Gildas GuitardPhilippe GouinAnna LamaczFabienne PlouvierBertrand DelabordeAïssa KherchacheAmina ChaalalJean-Damien RicardMarc AmourettiSantiago Freita-RamosDamien RouxJean-Michel ConstantinMona AssefiMarine LecoreAgathe SelvesFlorian PrevostChristian LamerRuiying ShiLyes KnaniSébastien Pili FlouryLucie VettorettiMichael LevyLucile MarsacStéphane DaugerSophie Guilmin-CréponHadrien WiniszewskiGaël PitonThibaud SoumagneGilles CapellierJean-Baptiste PutegnatFrédérique BayleMaya PerrouGhyslaine ThaoGuillaume GériCyril CharronXavier RepesséAntoine Vieillard-BaronMathieu GuilbartPierre-Alexandre RogerSébastien HinardPierre-Yves MacqKevin ChaulierSylvie GouttePatrick ChilletAnaïs PittaBarbara DarjentAmandine BruneauSigismond LasockiMaxime LegerSoizic GergaudPierre LemarieNicolas TerziCarole SchwebelAnaïs DartevelLouis-Marie GalerneauJean-Luc DiehlCaroline Hauw-BerlemontNicolas PéronEmmanuel GuérotAbolfazl Mohebbi AmoliMichel BenhamouJean-Pierre DeymeOlivier AndremontDiane LenaJulien CadyArnaud CauseretArnaud de la ChapelleChristophe CraccoStéphane RouleauDavid SchnellCamille FoucaultCécile LoryThibault ChapelleVincent BruckertJulie GarciaAbdlazize SahraouiNathalie AbboshCaroline BornstainPierre PernetFlorent PoirsonAhmed PasemPhilippe KaroubiVirginie PoupinelCaroline GauthierFrançois BouniolPhilippe FeuchereAnne HeronSerge CarreiraMalo EmeryAnne Sophie Le FlochLuana GiovannangeliNicolas HerzogChristophe GiacardiThibaut BaudicChloé ThillSaid LebbahJessica PalmyreFlorence TubachDavid HajageNicolas BonnetNathan EbsteinStéphane GaudryYves CohenJulie NoublancheOlivier LesieurArnaud SémentIsabel Roca-CerezoMichel PascalNesrine SmaGwenhaël ColinJean-Claude LacheradeGauthier BionzNatacha MaquigneauPierre BouzatMichel DurandMarie-Christine HéraultJean-Francois Payen
• Organismes : Optimisation thérapeutique en Neuropsychopharmacologie
• Publié dans Annals of Intensive Care le 23/10/2020

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• Type de publi. : Article dans une revue
• Date de publi. : 01/12/2022
• Auteurs : Sean BagshawAry Serpa NetoOrla SmithMatthew WeirHaibo QiuBin DuAmanda WangMartin GallagherRinaldo BellomoRon WaldNeill AdhikariDidier DreyfussMartin GallagherStéphane GaudryFrançois LamontagneMichael JoannidisKathleen LiuDaniel McauleyShay McguinnessAlistair NicholMarlies OstermannPaul PalevskyVille PettiläAntoine SchneiderOrla SmithSuvi VaaraGlenn EastwoodLeah PeckHelen YoungPeter KrugerGordon LaurieEmma SaylorJason MeyerEllen VenzKrista WetzigCraig FrenchForbes McgainJohn MulderGerard FennessySathyajith KoottayiSamantha BatesMiriam TownsRebecca MorganAnna TippettAndrew UdyChris MasonElisa LicariDashiell GantnerJason McclureAlistair NicholPhoebe MccrackenJasmin BoardEmma MartinShirley VallanceMeredith YoungChelsey VladicSteve McgloughlinDavid GattasHeidi BuhrJennifer ColesDebra HutchJames WunLouise ColeChristina WhiteheadJulie LowreyKristy MastersRebecca GreshamVictoria CampbellDavid GutierrezJane BrailsfordLoretta ForbesLauren MurrayTeena MaguireMartina NichonghaileNeil OrfordAllison BoneTania ElderkinTania SalernoTim ChimundaJason FletcherEmma BroadfieldSanjay PorwalCameron KnottCatherine BoschertJulie SmithAngus RichardsonDianne HillGraeme DukePeter OziemskiSantiago CegarraPeter ChanDeborah WelshStephanie HunterOwen RoodenburgJohn DyettNicos KokotsisMax MoserYang YangLaven PadayacheeJoseph VetroHimangsu GangopadhyayMelissa KaufmanAngaj GhoshSimone SaidAlpesh PatelShailesh BihariElisha MathesonXia JinTapaswi ShresthaKate SchwartzMartin GallagherRosalba CrossWinston CheungHelen WongMark KolAsim ShahZoltan EndreCelia BradfordPierre JaninSimon FinferNaomi DielJonathan GatwardNaomi HammondAnthony DelaneyFrances BassElizabeth YaradHergen BuscherClaire ReynoldsNerilee BakerMichael JoannidisRomuald BellmannAndreas PeerJulia HasslacherPaul KoglbergerSebastian KleinKlemens ZotterAnna BrandtnerArmin FinkenstedtAdelheid DitlbacherFrank HartigDietmar FriesMirjam BachlerBettina SchenkMartin WagnerPhilipp EllerThomas StaudingerEsther TillerPeter SchellongowskiAndja BojicEric HosteStephanie BrackeLuc de CropDaisy VermeirenFernando ThomeBianca ChiellaLucia FendtVeronica AntunesJean-Philippe LafranceFrançois LamontagneFrédérick D’aragonCharles St-ArnaudMichael MayetteÉlaine CarbonnaeuJoannie MarchandMarie-Hélène MasseMarilène LadouceurAlexis TurgeonFrançois LauzierDavid BellemareCharles Langis FrancoeurGuillaume LeblancGabrielle GuilbaultStéphanie GrenierEve CloutierAnnick BoivinCharles Delisle-ThibaultPanagiota GiannakourosOlivier CosterousseJean-François CailhierFrançois-Martin CarrierAli GhamraouiMartine LebrasseurFatna BenettaibMaya SalaméDounia BoumahniYing Tung SiaJean-François NaudIsabelle RoyHenry StelfoxStacey RuddellBraden MannsShelley DugganDominic CarneyJennifer BarchardRichard WhitlockEmilie Belley-CoteNevena SavijaAlexandra SabevTroy CampbellThais CrearyKelson DevereauxShira BrodutchClaudio RigattoBojan PaunovicOwen MooneyAnna GlybinaOksana HarasemiwMichelle Di NellaJohn HarmonNavdeep MehtaLouis LakatosNicole HaslamFrancois LelloucheMathieu SimonYing TungPatricia LizottePierre-Alexandre BourchardBram RochwergTim KarachiTina MillenJohn MuscedereDavid MasloveJ. Gordon BoydStephanie SibleyJohn DroverMiranda HuntIlinca GeorgescuRandy WaxIlan LengaKavita SridharAndrew SteeleKelly FuscoTaneera GhateMichael TolibasHolly RobinsonMatthew WeirRavi TanejaIan BallAmit GargEileen CampbellAthena OvsenekSean van DiepenNadia BaigSheldon MagderHan YaoAhsan AlamJosie CampisiErika MacintyreElla RokoshKimberly ScherrStephen LapinskySangeeta MehtaSumesh ShahDaniel NivenHenry StelfoxStacey RuddellMichael RussellKym JimGillian BrownKerry OxtobyAdam HallLuc BenoitColleen SokolowskiBhanu PrasadJag RaoShelley GiebelDemetrios KutsogiannisPatricia ThompsonTayne ThompsonRobert CironeKanthi KavikondalaMark SothFrance ClarkeAlyson TakaokaDavid MazerKaren BurnsJan FriedrichDavid KleinGyan SandhuMarlene SantosImrana KhalidJennifer HodderPeter DodekNajib AyasVictoria AlcuazGabriel SuenOleksa RewaGurmeet SinghSean NorrisNeil GibsonCastro AriasAysha ShamiCeline PelletierNeill AdhikariAlireza ZahiriehAndre AmaralNicole MarinoffNavjot KaurAdic PerezJane WangGregory HaljanChristopher CondinLauralyn McintyreBrigette GomesRebecca PorteousIrene WatpoolSwapnil HiremathEdward ClarkMargaret HerridgeFelicity BackhouseM. Elizabeth WilcoxKarolina WalczakVincent KiAsheer SharmanMartin RomanoR. GibneyAdam RomanovskyOleksa RewaLorena MccoshenNadia BaigGordon WoodDaniel OvakimFiona AuldGayle CarneyMeili DuanXiaojun JiDongchen GuoZhili QiJin LinMeng ZhangLei DongJingfeng LiuPei LiuDeyuan ZhiGuoqiang BaiYu QiuZiqi YangJing BaiZhuang LiuHaizhou ZhuangHaiman WangJian LiMengya ZhaoXiao ZhouXianqing ShiBaning YeManli LiuJing WuYongjian FuDali LongYu PanJinlong WangHuaxian MeiSongsong ZhangMingxiang WenEnyu YangSijie MuJianquan LiTingting HuBingyu QinMin LiCunzhen WangXin DongKaiwu WangHaibo WangJianxu YangChuanyao WangDongxin WangNan LiZhui YuSong XuLan YaoGuo HouZhou LiuLiping LuYingtao LianChunting WangJichen ZhangRuiqi DingGuoqing QiQizhi WangPeng WangZhaoli MengMan ChenXiaobo HuXiandi HeShibing ZhaoLele HangRui LiSuhui QinKun LuShijuan DunCheng LiuQi ZhouZhenzhen ChenJing MeiMinwei ZhangHao XuJincan LinQindong ShiLijuan FuQinjing ZengHongye MaJinqi YanLan GaoHongjuan LiuLei ZhangHao LiXiaona HeJingqun FanLitao GuoYu LiuXue WangJingjing SunZhongmin LiuJuan YangLili DingLulu ShengXingang LiuJie YanQuihui WangYifeng WangDan ZhaoShuangping ZhaoChenghuan HuJing LiFuxing DengYi YangMin MoChun PanChangde WuYingzi HuangLili HuangAiran LiuVille PettiläSuvi VaaraAnna-Maija KorhonenSanna TörnblomSari SutinenLeena PettiläJonna HeinonenEliria LappiTaria SuhonenSari KarlssonSanna HoppuVille JalkanenAnne KuitunenMarkus LevorantaJaakko LångsjöSanna RistimäkiKaisa MalilaAnna WoottenSimo VarilaMikko JärvisaloOuti InkinenSatu KentalaKeijo LeivoPaivi HaltiaDidier DreyfussJean-Damien RicardJonathan MessikaAbirami TiagarajahMalo EmeryAline DechanetCoralie GernezDamien RouxLaurent Martin-LefevreMaud FiancetteIsabelle VinatierJean Claude LacheradeGwenhaël ColinChristine LebertMarie-Ange AzaisAihem YehiaCaroline PoupletMatthieu Henry-LagarrigueAmélie SeguinLaura CrosbyJulien MaizelDimitri Titeca-BeauportAlain CombesAnia NieszkowskaPaul MasiAlexandre DemouleJulien MayauxMartin DresElise MorawiecMaxens DecalveleSuela DemiriMorgane FaureClémence MariosMaxime MalletMarie Amélie 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MonnierYannick RabouelHassene RahmaniHayat AllamSamir ChenafVincenta FranjaBertrand PonsMichel CarlesFrédéric MartinoRégine RichardBenjamin ZuberGuillaume LacaveKarim LakhalBertrand RozecHoa Dang VanÉric BouletFouad FadelCedric CleophaxNicolas DufourCaroline GrantMarie ThuongJean ReignierEmmanuel CanetLaurent NicoletThierry BoulainMai-Anh NayDalila BenzekriFrançois BarbierAnne BretagnolToufik KamelArmelle MathonnetGrégoire MullerMarie SkarzynskiJulie RossiAmandine PradetSandra dos SantosAurore GueryLucie MullerLuis FelixJulien BohéGuillaume ThiéryNadia AissaouiDamien VimpereMorgane CommeureucJean-Luc DiehlEmmanuel GuerotOrfeas LiangosMonika WittigAlexander ZarbockMira KüllmarThomas van WaegeninghNadine RosenowAlistair NicholKathy BrickellPeter DoranPatrick MurrayGiovanni LandoniRosalba LemboAlberto ZangrilloGiacomo MontiMargherita TozziMatteo MarzaroliGaetano LombardiGianluca PaternosterMichelangelo VitielloShay McguinnessRachael ParkeMagdalena ButlerEileen GilderKeri-Anne CowdreySamantha WallaceJane HallionMelissa WoolettPhilippa NealKarina DuffyStephanie LongColin McarthurCatherine SimmondsYan ChenRachael McconnochieLynette NewbyDavid KnightSeton HendersonJan MehrtensStacey MorganAnna MorrisKymbalee Vander HaydenTara BurkeMatthew BaileyRoss FreebairnLesley ChadwickPenelope ParkChristine RollsLiz ThomasUlrike BuehnerErin WilliamsJonathan AlbrettSimon KirkhamCarolyn JacksonTroy BrowneJennifer GoodsonDavid JacksonJames HoughtonOwen CallenderVicki HigsonOwen KeetClive DominyPaul YoungAnna HuntHarriet JuddCassie LawrenceShaanti OlatunjiYvonne RobertsonCharlotte Latimer-BellDeborah HendryAgnes Mckay-VucagoNina BeehreEden LesonaLeanlove NavarraChelsea RobinsonRyan JangAndrea JungeBridget LambertAntoine SchneiderMichel ThibaultPhilippe EckertSébastien KisslingErietta PolychronopoulosElettra PoliMarco AltarelliMadeleine SchnorfSamia Abed MallairdClaudia HeideggerAurelie PerretPhilippe MontillierFrederic SanglaSeigenthaller NeilsAude de WattevilleMandeep-Kaur PhullAparna GeorgeNauman HussainTatiana PogrebanSteve LobazAlison DanielsMishell CunninghamDeborah KerrAlice NicholsonPradeep ShanmugasundaramJudith AbramsKatarina MansoGeraldine HambrookElizabeth MckerrowJuvy SalvaStephen FoulkesMatthew WiseMatt MorganJenny BrooksJade ColeTracy Michelle DaviesHelen HillEmma ThomasMarcela VizcaychipiBehrad BaharloJaime CarungcongPatricia CostaLaura MartinsRitoo KapoorTracy HazeltonAngela MoonJanine MusselwhiteBen ShelleyPhilip MccallMarlies OstermannGill ArbaneAneta BociekMartina MarottiRosario LimSara CamposNeus Grau NovellasArmando CennamoAndrew SlackDuncan WyncollLuigi CamporotaSimon SparkesRosalinde TilleyAustin RattrayGayle MorelandJane DuffyElizabeth McgonigalPhilip HopkinsClare FinneyJohn SmithHarriet NobleHayley WatsonClaire-Louise HarrisEmma ClareyEleanor CorcoranJames BeckClare HowcroftNora YoungsElizabeth WilbyBethan OggAdam WolversonSandra LeeSusie ButlerMaryanne OkubanjoJulia HindleIngeborg WeltersKaren WilliamsEmily JohnsonJulie Patrick-HeseltonDavid ShawVictoria WaughRichard StewartEsther MwauraLynn WrenLouise MewSara-Beth SutherlandJane AdderleyJim RuddyMargaret HarkinsCallum KayeTeresa ScottWendy MitchellFelicity AndersonFiona WilloxVijay JagannathanMichele ClarkSarah PurvAndrew SharmanMegan MeredithLucy RyanLouise ConnerCecilia PetersDan HarveyAshraf RoshdyAmy CollinsMalcolm SimSteven HendersonNigel CheeSally PittsKatie BowmanMaria DilawershahLuke VamplewElizabeth HowePaula RogersClara HernandezClara PrendergastJane BentonAlex RosenbergLui ForniAlice GrantPaula CarvelliAjay RaithathaSarah BirdMax RichardsonMatthew NeedhamClaire HirstJonathan BallSusannah LeaverLuisa HowlettCarlos Castro DelgadoSarah Farnell-WardHelen FarrahGeraldine GrayGipsy JosephFrancesca RobinsonAscanio TridenteClare HarropKaren ShukerDerek MclaughlanJudith RamseySharon MeehanBernd Oliver RoseRosie Reece-AnthonyBabita GurungTony WhitehouseCatherine SnelsonTonny VeenithAndy JohnstonLauren CooperRon CarreraKaren EllisEmma FellowsSamanth HarkettColin BerginElaine SpruceLiesl DespyStephanie GoundryNatalie DooleyTracy MasonAmy ClarkGemma DignamGeraldine WardBen AttwoodPenny ParsonsSophie MasonMichael MargarsonJenny LordPhilip McgloneLuke HodgsonIndra ChadbournRaquel GomezJordi MargalefRinus PretoriusAlexandra HamshereJoseph CarterHazel CahillLia GraingerKate HowardGreg ForshawZoe GuyKianoush KashaniRobert AlbrightAmy AmsbaughAnita StoltenbergAlexander NivenMatthew LynchAnnmarie O’maraSyed NaeemSairah SharifJoyce Mckenney GoulartAshita TolwaniClaretha LyasLaura LattaAzra BihoracHaleh HashemighouchaniPhilip EfronMatthew RuppertJulie CupkaSean KileyJoshua CarsonPeggy WhiteGeorge OmalaySherry BrownLaura VelezAlina MarceronJavier NeyraJuan Carlos AycinenaMadona EliasVictor Ortiz-SorianoCaroline HauschildRobert Dorfman
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans Intensive Care Medicine le 27/10/2020

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