Philippe JEAN-PIERRE

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• Type de publi. : Article dans une revue
• Date de publi. : 21/12/2022
• Auteurs : Tao-Chung ChingKeping QiuDi LiZhiyuan 致远 Ren 任Shih-Ping LaiDavid BerryKate PattleRay FuruyaDaniel R. van RossumDoug JohnstonePatrick M KochC.-W. LeeThiem HoangTetsuo HasegawaWoojin KwonPierre BastienChakali EswaraiahJia-Wei WangKyoung Hee KimJihye HwangArchana SoamA.-Ran LyoJunhao LiuValentin Le GouellecDoris ArzoumanianAnthony WhitworthJames Di FrancescoF PoidevinTie 铁 Liu 刘Simon CoudéMehrnoosh TahaniHong-Li LiuTakashi OnakaDalei LiMotohide TamuraZhiwei ChenXindi TangFlorian KirchschlagerTyler BourkeDo-Young ByunMike ChenHuei-Ru Vivien ChenWen Ping ChenJungyeon ChoYunhee ChoiYoungwoo ChoiMinho ChoiA. ChrysostomouEun Jung ChungY. Sophia DaiP. DiepYasuo DoiYan DuanHao-Yuan DuanD. EdenLapo FanciulloJason FiegeLaura FisselErica FranzmannPer FribergRachel FriesenGary FullerTim GledhillSarah GravesJane GreavesMatt GriffinQi-Lao 琦烙 Gu 顾Ilseung HanSaeko HayashiMartin HoudeCharles L H HullTsuyoshi InoueShu-Ichiro InutsukaKazunari IwasakiIl-Gyo JeongVera KönyvesJi-Hyun KangMiju KangJanik KarolyAkimasa KataokaKoji S KawabataFrancisca KemperJongsoo KimMi-Ryang KimShinyoung KimHyosung KimKee-Tae KimGwanjeong KimJason KirkMasato KobayashiTakayoshi KusuneJungmi KwonKevin LacailleChi-Yan LawSang-Sung LeeHyeseung LeeJeong-Eun LeeChin-Fei LeeYong-Hee LeeGuangxing LiHua-Bai LiSheng-Jun 聖鈞 Lin 林Sheng-Yuan LiuXing LuSteve MairsMasafumi 雅文 Matsumura 松村Brenda MatthewsGerald Moriarty-SchievenTetsuya NagataSandhyarani PanigrahyHiroyuki NakanishiNguyen Bich NgocNagayoshi OhashiGeumsook ParkHarriet ParsonsNicolas PerettoFelix PriestleyTae-Soo PyoLei QianRamprasad RaoMark RawlingsJonathan RawlingsBrendan RetterJohn RicherAndrew RigbySarah SadavoyHiro SaitoGiorgio SaviniMasumichi SetaYoshito ShimajiriHiroko ShinnagaYa-Wen TangKohji TomisakaLe Ngoc TramYusuke TsukamotoSerena VitiHongchi WangJintai WuJinjin XieMeng-Zhe YangHsi-Wei YenHyunju YooJinghua YuanHyeong-Sik YunTetsuya ZenkoChuan-Peng ZhangYapeng ZhangGuoyin ZhangJianjun ZhouLei ZhuIlse de LoozePh. AndréC. Darren DowellStewart EyresSam FalleJean-François RobitailleSven van Loo
• Organismes : Max Planck Institute for Radio Astronomy
• Publié dans The Astrophysical Journal le 22/10/2020

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Résumé : Abstract We present 850 μ m dust polarization observations of the massive DR21 filament from the B -fields In STar-forming Region Observations (BISTRO) survey, using the POL-2 polarimeter and the SCUBA-2 camera on the James Clerk Maxwell Telescope. We detect ordered magnetic fields perpendicular to the parsec-scale ridge of the DR21 main filament. In the subfilaments, the magnetic fields are mainly parallel to the filamentary structures and smoothly connect to the magnetic fields of the main filament. We compare the POL-2 and Planck dust polarization observations to study the magnetic field structures of the DR21 filament on 0.1–10 pc scales. The magnetic fields revealed in the Planck data are well-aligned with those of the POL-2 data, indicating a smooth variation of magnetic fields from large to small scales. The plane-of-sky magnetic field strengths derived from angular dispersion functions of dust polarization are 0.6–1.0 mG in the DR21 filament and ∼0.1 mG in the surrounding ambient gas. The mass-to-flux ratios are found to be magnetically supercritical in the filament and slightly subcritical to nearly critical in the ambient gas. The alignment between column density structures and magnetic fields changes from random alignment in the low-density ambient gas probed by Planck to mostly perpendicular in the high-density main filament probed by James Clerk Maxwell Telescope. The magnetic field structures of the DR21 filament are in agreement with MHD simulations of a strongly magnetized medium, suggesting that magnetic fields play an important role in shaping the DR21 main filament and subfilaments.

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• Type de publi. : Article dans une revue
• Date de publi. : 21/12/2022
• Auteurs : Lévi-Dan AzoulayMarine BravettiFleur Cohen-AubartJean-François EmileDanielle SeilheanIsabelle PluFrédéric CharlotteXavier WaintraubFabrice CarratZahir AmouraPhilippe CluzelJulien Haroche
• Organismes : CHU Pitié-Salpêtrière [AP-HP] Sorbonne Université CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Hôpital Ambroise Paré [AP-HP] Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut de cardiologie [CHU Pitié-Salpêtrière] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Saint-Antoine [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP]
• Publié dans European Heart Journal le 30/10/2020

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Résumé : Abstract Aims Cardiac involvement of Erdheim–Chester disease (ECD), a rare L group histiocytosis, has been reported to be associated with poor outcomes, but systematic studies are lacking. The present study aimed to investigate the prevalence, clinical features, imaging features, and prognosis of cardiac involvement in ECD in a large series. Methods and results All patients with ECD who underwent cardiac magnetic resonance (CMR) imaging between 2003 and 2019 at a French tertiary center were retrospectively included. Primary outcome was all-cause mortality. Secondary outcomes were pericarditis, cardiac tamponade, conduction disorders, device implantation and coronary artery disease (CAD). A total of 200 patients were included [63 (54–71) years, 30% female, 58% BRAFV600E mutated]. Median follow-up was 5.5 years (3.3–9 years). On CMR, right atrioventricular sulcus infiltration was observed in 37% of patients, and pericardial effusion was seen in 24% of patients. In total, 8 patients (4%) had pericarditis (7 acute, 1 constrictive), 10 patients (5%) had cardiac tamponade, 5 patients (2.5%) had ECD-related high-degree conduction disorders, and 45 patients (23%) had CAD. Overall, cardiac involvement was present in 96 patients (48%) and was associated with BRAFV600E mutation [Odds ratio (OR) = 7.4, 95% confidence interval (CI) (3.5–16.8), P < 0.001] and ECD-related clinical events [OR = 5, 95%CI (1.5–21.2), P = 0.004] but not with lower survival in multivariate analysis [adjusted hazard ratio (HR) = 1.4, 95% CI (0.8–2.5), P = 0.2]. Conclusion Cardiac involvement is present in nearly half of ECD patients and is associated with BRAFV600E mutation and complications (pericarditis, cardiac tamponade, and conduction disorders) but not with lower survival.

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Fichiers liés : Manuscript_ECD_HEART_EHJ_R4_PL.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 20/12/2022
• Auteurs : Marianne GazzanoChristophe ParizotDimitri PsimarasAurore VozyMarine BaronBaptiste AbbarVincent FalletElena LitvinovaAnthony CanellasCristina BirzuValérie PourcherMehdi TouatNicolas WeissSophie DemeretDamien Roos-WeilJean-Philippe SpanoCeleste LebbeJoe‐elie SalemJacques CadranelBaptiste HervierGuy GorochovAmélie Guihot
• Organismes : CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Tenon [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Institut Pierre Louis d'Epidémiologie et de Santé Publique CHU Pitié-Salpêtrière [AP-HP] Institut du Cerveau = Paris Brain Institute CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Epidémiologie, Systèmes d'Information, Modélisation CHU Pitié-Salpêtrière [AP-HP] Hopital Saint-Louis [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases CHU Tenon [AP-HP] Hopital Saint-Louis [AP-HP] CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Centre d'Immunologie et des Maladies Infectieuses
• Publié dans Frontiers in Immunology le 25/10/2020

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Résumé : Immune checkpoint inhibitors (ICI) widely improved the treatment of solid and hematologic malignancies. Yet, a remarkable proportion of patients receiving ICI develop immune related adverse events (irAEs) which are difficult to define as treatment-related. This underlines the need to develop a biomarker to guide irAE diagnosis. We developed a novel flow cytometry assay combining measurement of anti-PD-1 (programmed cell death protein-1) occupancy and evaluation of remaining PD-1 receptor availability with anti-IgG4 PE and anti-PD-1 BV421. We prospectively collected blood and biological fluids samples from patients treated by IgG4 anti-PD-1 therapy (nivolumab or pembrolizumab), with (n=18) or without (n=12) current irAE. We analyzed PD-1+ and IgG4+ staining pattern and MFI values of these parameters on CD4 and CD8 T cells, and IgG4+/PD-1+ MFI ratios are calculated. A higher mean fluorescence intensity IgG4+/PD-1+ ratio was measured on peripheral CD4+ T cells of irAE cases, when compared to controls (p=0.003). ICI-related toxicity is therefore associated with increased therapeutic antibody occupancy of PD-1 receptors on CD4+ T cells. Furthermore, in one case of ICI-related pneumonitis, binding of therapeutic antibody was stronger on lung CD4+ T cell than in blood. In another case of ICI-related encephalitis, the PD-1 receptor occupancy was total on CSF CD4 T cells, but only partial on peripherical CD4 T cells. Our results suggest that flow cytometry monitoring of ICI occupancy can be used in patients treated with monoclonal ICI to guide irAE diagnosis.

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Fichiers liés : Anti-PD-1 immune-related adverse events are associated with high therapeutic antibody fixation on T cells.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2022
• Auteurs : Olivier MousisAlexis BouquetYves LangevinNicolas AndréHélène BoithiasGeorges DurryF. FayePaul HartoghJ. HelbertLuciano IessS KempfAdam MastersF PostbergJean-Baptiste RenardPierre VernazzaA VorburgerP. WurzD. H. AtkinsonS BarabashMatthieu BerthomierJohn Robert BrucatoM CableJohn CarterS CazauxAthena CoustenisGrégoire DangerVéronique DehantTeresa FornaroPhilippe GarnierThomas GautierOlivier GroussinL. Z. HadidJ-C IzeI. KolmasovaJ-P LebretonS Le MaistreEmmanuel LellouchJonathan LunineKathleen MandtZita MartinsDavid MimounQuentin NénonGuillermo M Muñoz CaroPascal RannouH RauerPhilippe Schmitt-KopplinAntoine SchneebergerM. SimonsK StephanT. van HoolstJ. VaverkaM. WieserL Wörner
• Organismes : Laboratoire d'Astrophysique de Marseille Institut universitaire de France Laboratoire d'Astrophysique de Marseille Physique des interactions ioniques et moléculaires Institut d'astrophysique spatiale Institut de recherche en astrophysique et planétologie Airbus Defence and Space [Les Mureaux] Groupe de spectrométrie moléculaire et atmosphérique Airbus Defence and Space [Les Mureaux] Max-Planck-Institut für Sonnensystemforschung = Max Planck Institute for Solar System Research DLR Institut für Planetenforschung Dipartimento di Ingegneria Meccanica e Aerospaziale [Roma La Sapienza] Laboratory for Atmospheric and Space Physics [Boulder] Imperial College London Institute of Geological Sciences [Berlin] Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Laboratoire d'Astrophysique de Marseille Physics Institute [Bern] Physics Institute [Bern] Jet Propulsion Laboratory Swedish Institute of Space Physics [Kiruna] Laboratoire de Physique des Plasmas INAF- Osservatorio Astrofisico di Arcetri Jet Propulsion Laboratory Laboratoire d'Astrophysique de Marseille Faculty of Aerospace Engineering [Delft] Leiden Observatory [Leiden] Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Physique des interactions ioniques et moléculaires Institut universitaire de France Royal Observatory of Belgium = Observatoire Royal de Belgique INAF- Osservatorio Astrofisico di Arcetri Institut de recherche en astrophysique et planétologie Institut Universitaire de Technologie - Paul Sabatier PLANETO - LATMOS Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Laboratoire d'Astrophysique de Marseille Laboratoire de Physique des Plasmas Laboratoire d'Astrophysique de Marseille Institute of Atmospheric Physics of the Czech Academy of Sciences Faculty of Mathematics and Physics [Praha/Prague] Laboratoire de Physique et Chimie de l'Environnement et de l'Espace Royal Observatory of Belgium = Observatoire Royal de Belgique Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Department of Astronomy [Ithaca] Johns Hopkins University Applied Physics Laboratory [Laurel, MD] Centro de Quimica Estrutural Institut Supérieur de l'Aéronautique et de l'Espace Institut de recherche en astrophysique et planétologie Centro de Astrobiologia [Madrid] Groupe de spectrométrie moléculaire et atmosphérique DLR Institut für Planetenforschung Max-Planck-Institut für Extraterrestrische Physik Laboratoire d'Astrophysique de Marseille Seismological Laboratory, California Institute of Technology DLR Institut für Planetenforschung Laboratoire d'études spatiales et d'instrumentation en astrophysique = Laboratory of Space Studies and Instrumentation in Astrophysics Faculty of Mathematics and Physics [Praha/Prague] Swedish Institute of Space Physics [Kiruna] DLR In­sti­tute of Quan­tum Tech­nolo­gies
• Publié dans The Planetary Science Journal le 01/11/2020

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Résumé : Enceladus, an icy moon of Saturn, possesses an internal water ocean and jets expelling ocean material into space. Cassini investigations indicated that the subsurface ocean could be a habitable environment having a complex interaction with the rocky core. Further investigation of the composition of the plume formed by the jets is necessary to fully understand the ocean, its potential habitability, and what it tells us about Enceladus's origin. Moonraker has been proposed as an ESA M-class mission designed to orbit Saturn and perform multiple flybys of Enceladus, focusing on traversals of the plume. The proposed Moonraker mission consists of an ESA-provided platform with strong heritage from JUICE and Mars Sample Return and carrying a suite of instruments dedicated to plume and surface analysis. The nominal Moonraker mission has a duration of ∼13.5 yr. It includes a 23-flyby segment with 189 days allocated for the science phase and can be expanded with additional segments if resources allow. The mission concept consists of investigating (i) the habitability conditions of present-day Enceladus and its

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Fichiers liés : Mousis_2022_Planet._Sci._J._3_268.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2022
• Auteurs : Sassan S SaatchiWigneron J.-P.Philippe CiaisJérôme ChaveMartin BrandtStephen SitchChao YueAna BastosAndre F FeldmanYuanwei QinWenping YuanDmitry SchepaschenkoLiudmila MukhortovaXiaojun LiXiangzhuo LiuMengjia WangFrédéric FrappartXiangming XiaoJingming ChenMingguo MaJianguang WenXiuzhi ChenHui YangDave van WeesRasmus Fensholt
• Organismes : Southwest University [Chongqing] Interactions Sol Plante Atmosphère Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Evolution et Diversité Biologique Department of Geosciences and Natural Resource Management [Copenhagen] College of Life and Environmental Sciences [Exeter] Northwest A & F University Max Planck Institute for Biogeochemistry Institute of Tibetan Plateau Research Chinese Academy of Sciences [Beijing] Department of Microbiology and Plant Biology University of Oklahoma National Sun Yat-sen University Sun Yat-sen University [Guangzhou] V.N. Sukachev Institute of Forest Siberian Federal University V.N. Sukachev Institute of Forest Siberian Branch of the Russian Academy of Sciences Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère University of Oklahoma Interactions Sol Plante Atmosphère Interactions Sol Plante Atmosphère Department of Microbiology and Plant Biology National Sun Yat-sen University University of Toronto Southwest University [Chongqing] State Key Laboratory of Remote Sensing Science Chinese Academy of Sciences [Beijing] Sun Yat-sen University [Guangzhou] Max Planck Institute for Biogeochemistry Vrije Universiteit Brussel [Bruxelles] Department of Geosciences and Natural Resource Management [Copenhagen] IT University of Copenhagen
• Publié dans Nature Geoscience le 26/10/2020

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Résumé : Siberian forests are generally thought to have acted as an important carbon sink over recent decades, but exposure to severe droughts and fire disturbances may have impacted their carbon dynamics. Limited available forest inventories mean the carbon balance remains uncertain. Here we analyse annual live and dead above-ground carbon changes derived from low-frequency passive microwave observations from 2010 to 2019. We find that during this period, the carbon balance of Siberian forests was close to neutral, with the forests acting as a small carbon sink of +0.02+0.03+0.01 PgC yr−1. Carbon storage in dead wood increased, but this was largely offset by a decrease in live biomass. Substantial losses of live above-ground carbon are attributed to fire and drought, such as the widespread fires in northern Siberia in 2012 and extreme drought in eastern Siberia in 2015. These live above-ground carbon losses contrast with ‘greening’ trends seen in leaf area index over the same period, a decoupling explained by faster post-disturbance recovery of leaf area than live above-ground carbon. Our study highlights the vulnerability of large forest carbon stores in Siberia to climate-induced disturbances, challenging the persistence of the carbon sink in this region of the globe.

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Fichiers liés : Siberian%20carbon%20sink%20reduced%20by%20forest%20disturbances_Preprint.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 12/12/2022
• Auteurs : Jihye HwangJongsoo KimKate PattleC.-W. LeePatrick M KochDoug JohnstoneKohji TomisakaAnthony WhitworthRay FuruyaJi-Hyun KangA.-Ran LyoEun Jung ChungDoris ArzoumanianGeumsook ParkWoojin KwonShinyoung KimMotohide TamuraJungmi KwonArchana SoamIlseung HanThiem HoangKyoung Hee KimTakashi OnakaChakali EswaraiahDaniel R. van RossumHong-Li LiuXindi TangWen Ping ChenMasafumi 雅文 Matsumura 松村Thuong Duc HoangZhiwei ChenValentin Le GouellecFlorian KirchschlagerF PoidevinPierre BastienKeping QiuTetsuo HasegawaShih-Ping LaiDo-Young ByunJungyeon ChoMinho ChoiYoungwoo ChoiYunhee ChoiIl-Gyo JeongMiju KangHyosung KimKee-Tae KimJeong-Eun LeeSang-Sung LeeYong-Hee LeeHyeseung LeeMi-Ryang KimHyunju YooHyeong-Sik YunMike ChenJames Di FrancescoJason FiegeLaura FisselErica FranzmannMartin HoudeKevin LacailleBrenda MatthewsSarah SadavoyGerald Moriarty-SchievenMehrnoosh TahaniTao-Chung ChingY. Sophia DaiYan DuanQi-Lao 琦烙 Gu 顾Chi-Yan LawDalei LiDi LiGuangxing LiHua-Bai LiTie 铁 Liu 刘Xing LuLei QianHongchi WangJintai WuJinjin XieJinghua YuanChuan-Peng ZhangGuoyin ZhangYapeng ZhangJianjun ZhouLei ZhuDavid BerryPer FribergSarah GravesJunhao LiuSteve MairsHarriet ParsonsMark RawlingsYasuo DoiSaeko HayashiCharles L H HullTsuyoshi InoueShu-Ichiro InutsukaKazunari IwasakiAkimasa KataokaKoji S KawabataGwanjeong KimMasato KobayashiTetsuya NagataSandhyarani PanigrahyHiroyuki NakanishiTae-Soo PyoHiro SaitoMasumichi SetaYoshito ShimajiriHiroko ShinnagaYusuke TsukamotoTetsuya ZenkoHuei-Ru Vivien ChenHao-Yuan DuanLapo FanciulloFrancisca KemperChin-Fei LeeSheng-Jun 聖鈞 Lin 林Sheng-Yuan LiuNagayoshi OhashiRamprasad RaoYa-Wen TangJia-Wei WangMeng-Zhe YangHsi-Wei YenTyler BourkeA. ChrysostomouVictor DebattistaD. EdenStewart EyresSam FalleGary FullerTim GledhillJane GreavesMatt GriffinJennifer HatchellJanik KarolyJason KirkVera KönyvesS. LongmoreSven van LooIlse De LoozeNicolas PerettoFelix PriestleyJonathan RawlingsBrendan RetterJohn RicherAndrew RigbyGiorgio SaviniAnna ScaifeSerena VitiP. DiepNguyen Bich NgocLe Ngoc TramPh. AndréSimon CoudéC. Darren DowellRachel FriesenJean-François Robitaille
• Organismes : Korea Astronomy and Space Science Institute Max Planck Institute for Radio Astronomy
• Publié dans The Astrophysical Journal le 22/10/2020

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Résumé : Abstract We present and analyze observations of polarized dust emission at 850 μ m toward the central 1 × 1 pc hub-filament structure of Monoceros R2 (Mon R2). The data are obtained with SCUBA-2/POL-2 on the James Clerk Maxwell Telescope (JCMT) as part of the B-fields in Star-forming Region Observations survey. The orientations of the magnetic field follow the spiral structure of Mon R2, which are well described by an axisymmetric magnetic field model. We estimate the turbulent component of the magnetic field using the angle difference between our observations and the best-fit model of the underlying large-scale mean magnetic field. This estimate is used to calculate the magnetic field strength using the Davis–Chandrasekhar–Fermi method, for which we also obtain the distribution of volume density and velocity dispersion using a column density map derived from Herschel data and the C 18 O ( J = 3 − 2) data taken with HARP on the JCMT, respectively. We make maps of magnetic field strengths and mass-to-flux ratios, finding that magnetic field strengths vary from 0.02 to 3.64 mG with a mean value of 1.0 ± 0.06 mG, and the mean critical mass-to-flux ratio is 0.47 ± 0.02. Additionally, the mean Alfvén Mach number is 0.35 ± 0.01. This suggests that, in Mon R2, the magnetic fields provide resistance against large-scale gravitational collapse, and the magnetic pressure exceeds the turbulent pressure. We also investigate the properties of each filament in Mon R2. Most of the filaments are aligned along the magnetic field direction and are magnetically subcritical.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 08/12/2022
• Auteurs : Véronique SuissaSerge GuérinPhilippe Denormandie
• Organismes : Agence des Médecines Complémentaires Adaptées (A-MCA) Le Journal de l'Hypnose et de la santé intégrative (DUNOD) ESG Research Lab Institut du Bien Vieillir [Paris]

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Résumé : La prévention a été élevée au rang de priorité gouvernementale, jusque dans l’intitulé du nouveau ministère de la Santé et de la prévention. Les débats initiés autour des questions de santé, de culture de la prévention et de complémentarité entre les soins ont pris une place encore plus importante depuis la crise de la covid. C’est dans ce cadre que l’A-MCA a souhaité porter les premières rencontres de la prévention. Dans un moment où les Français recherchent une meilleure qualité de vie, l’enjeu est de pouvoir réfléchir collectivement aux leviers permettant d’introduire une véritable culture de la prévention en santé, de pouvoir s’intéresser à la prévention de manière transverse en abordant différents contextes (écoles, entreprise, habitat) et différents publics (jeunes, adultes, personnes âgées). Au programme : Une diversité d'intervenants (médecins, chercheurs, haut-dirigeants, soignants, praticiens...) pour évoquer de façon transverse la prévention à tous les âges de la vie (bien grandir, bien vivre, bien vieillir). Modérée Par Véronique Suissa, Serge Guérin et sous le Haut Patronage de Madame la Députée Anie VIDAL Intervenants : Dr Alain Ducardonet, Dr Adrian Chaboche, Benoit Péricart, Pascal Brunelet, Pr Jean-Pierre Klein, Mario Bastone, etc.

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• Type de publi. : Communication dans un congrès
• Date de publi. : 07/12/2022
• Auteurs : Jean SeegersOlivier DupirePhilippe DimonVincent BelletNicole BossisEmmanuel MorinPierre Lemeunier
• Organismes : Institut de l'élevage

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Résumé : Autonomie en paille et poids économique des achats de litières dans les exploitations d'élevage : analyse rétrospective des données INOSYS Réseaux d'élevage 2001-2020

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Fichiers liés : 3R_2022_396264_Seegers_J_v2_deposee_sans_numeros_de_lignes.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 06/12/2022
• Auteurs : Andy KarabajakianThibaut GarrivierCarole CrozesNicolas GadotJean-Yves BlayFrédéric BérardPhilippe CérusePhilippe ZrounbaPierre SaintignyCharles MastierJérôme Fayette
• Organismes : Hospices Civils de Lyon Immunité de l’épiderme & allergie - Epidermal Immunity and Allergy [CIRI]
• Publié dans Oncotarget le 22/10/2020

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Résumé : Abstract Introduction/Background Manifestations of psoriasis in special areas are difficult to treat and are associated with a high disease burden and significant quality of life (QoL) impairment. Topical therapies may be inadequate for these patients, necessitating systemic treatment. Objective The objective of EMBRACE was to evaluate the impact on QoL, efficacy and safety of apremilast 30 mg BID in patients with limited skin involvement with plaque psoriasis manifestations in special areas and impaired QoL. Methods EMBRACE (NCT03774875) was a phase 4, randomized, placebo‐controlled, multinational study. Patients had plaque psoriasis not controlled by topical therapy; lack of response, contraindication or intolerance to conventional first‐line systemic therapy; psoriasis in ≥1 special area (including visible locations, scalp, nails, genital areas or palmoplantar areas); Psoriasis Area and Severity Index (PASI) ≥3 to ≤10; and Dermatology Life Quality Index (DLQI) >10. The primary endpoint was DLQI response (≥4‐point reduction) at Week 16. Results Of 277 randomized patients (apremilast: n = 185; placebo: n = 92), 221 completed Week 16 (apremilast: n = 152; placebo: n = 69). The primary endpoint (≥4‐point reduction in DLQI at Week 16) was met by significantly more patients receiving apremilast (73.3%) versus placebo (41.3%; p < 0.0001). Significantly greater improvement in affected body surface area (BSA) and PASI was observed with apremilast versus placebo at Week 16. There were also significantly greater improvements with apremilast versus placebo in itch numeric rating scale (−2.5 vs. −0.9, p < 0.0001) and skin discomfort/pain visual analog scale (−21.5 vs. −5.4, p = 0.0003) and greater achievement of Patient Benefit Index ≥1 (77% vs. 40%, p < 0.0001) at Week 16. No new safety signals were observed. Conclusions Apremilast significantly improved skin‐related QoL in patients with limited skin involvement with plaque psoriasis in special areas and highly impaired QoL. The safety profile was consistent with prior apremilast studies.

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• Type de publi. : Article dans une revue
• Date de publi. : 05/12/2022
• Auteurs : Marie LabatJ P Couperus CabadağAmin GhaithArie IrmanAnthony BerliouxPhilippe BerteaudFrédéric BlacheStefan BockFrançois BouvetFabien BriquezYen-Yu ChangSébastien CordeAlexander DebusCarlos de OliveiraJean-Pierre DuvalYannick DietrichMoussa El AjjouriChristoph EisenmannJulien GautierRené GebhardtSimon GramsUwe HelbigChristian HerbeauxNicolas HubertCharles KitegiOlena KononenkoMichael KuntzschMaxwell LabergeStéphane LêBruno LeluanAlexandre LoulergueVictor MalkaFabrice MarteauManh Huy N. GuyenDriss Oumbarek-EspinosRichard PauschDamien PereiraThomas PüschelJean-Paul RicaudPatrick RommeluereEléonore RousselPascal RousseauSusanne SchöbelMourad SebdaouiKlaus SteinigerKeihan TavakoliCedric ThauryPatrick UferMathieu ValléauMarc VandenbergheJosé VétéranUlrich SchrammMarie-Emmanuelle Couprie
• Organismes : Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Helmholtz-Zentrum Dresden-Rossendorf Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Helmholtz-Zentrum Dresden-Rossendorf University of Texas at Austin [Austin] Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Laboratoire d'Optique Appliquée Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Laboratoire d'Optique Appliquée Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL Synchrotron SOLEIL Synchrotron SOLEIL Helmholtz-Zentrum Dresden-Rossendorf Synchrotron SOLEIL
• Publié dans Nature Photonics le 01/11/2020

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Résumé : Abstract Free-electron lasers generate high-brilliance coherent radiation at wavelengths spanning from the infrared to the X-ray domains. The recent development of short-wavelength seeded free-electron lasers now allows for unprecedented levels of control on longitudinal coherence, opening new scientific avenues such as ultra-fast dynamics on complex systems and X-ray nonlinear optics. Although those devices rely on state-of-the-art large-scale accelerators, advancements on laser-plasma accelerators, which harness gigavolt-per-centimetre accelerating fields, showcase a promising technology as compact drivers for free-electron lasers. Using such footprint-reduced accelerators, exponential amplification of a shot-noise type of radiation in a self-amplified spontaneous emission configuration was recently achieved. However, employing this compact approach for the delivery of temporally coherent pulses in a controlled manner has remained a major challenge. Here we present the experimental demonstration of a laser-plasma accelerator-driven free-electron laser in a seeded configuration, where control over the radiation wavelength is accomplished. Furthermore, the appearance of interference fringes, resulting from the interaction between the phase-locked emitted radiation and the seed, confirms longitudinal coherence. Building on our scientific achievements, we anticipate a navigable pathway to extreme-ultraviolet wavelengths, paving the way towards smaller-scale free-electron lasers, unique tools for a multitude of applications in industry, laboratories and universities.

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Fichiers liés : Seeded_free-electron_laser_driven_by_a_compact_las.pdf

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