Philippe JEAN-PIERRE

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• Type de publi. : Communication dans un congrès
• Date de publi. : 11/10/2022
• Auteurs : Philippe CarerMouna RifiAurelie DehouckEric SuignardDamien BortolottiJean-Pierre DucreuxSalhab ElieGougeon StéphaneMedhi KanounMarie- Laure Parussolo-PaupardinDominique Hadbi TalbourdetMohamed ZoutiEric Ortega
• Organismes : EDF R&D SYSTEME Laboratoire d'Informatique de Paris-Nord EDF R&D SYSTEME EDF R&D SYSTEME EDF R&D SYSTEME ElectRotechnique et MEcanique des Structures Saclay Industrial Lab for Artificial Intelligence Research Ecole Supérieure d'Electricité - SUPELEC (FRANCE) PERformance et prévention des Risques Industriels du parC par la simuLation et les EtudeS Laboratoire des Matériels Électriques Laboratoire des Matériels Électriques Laboratoire des Matériels Électriques Enedis Enedis

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Résumé : La gestion des actifs des réseaux électriques comme les transformateurs HTB/HTA, les câbles HTA, ou les onduleurs DC/AC, est très importante pour les gestionnaires de réseau électrique. Cet article a pour objectif de comparer deux méthodes pour les arbitrages maintenance/renouvellement des composants électriques, la méthode « Health Index (ou indicateur de santé) », et la méthode utilisée en fiabilité. La première méthode « Health Index » est plutôt utilisée par les constructeurs et/ou les exploitants de composants électriques. La seconde correspond à l'état de l'art en fiabilité pour la gestion des actifs selon une approche probabiliste. On prend en compte pour chacun des composants, transformateur, câble, ou onduleur, leurs spécificités techniques. On décrit le fait que depuis quelques années ces différents composants font l'objet d'instrumentation avec des capteurs permettant à termes de suivre en temps réel l'état de ces composants.

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Fichiers liés : 3B - Comparaison méthode Health Index versus méthode de fiabilité et données terrain pour la gestion des actifs transformateur HTBHTA, câble HTA, et onduleur DCAC.pdf

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Source

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• Type de publi. : Autre publication
• Date de publi. : 10/10/2022
• Auteurs : Nicolas AragonPaulo BarretoSlim BettaiebLoïc BidouxOlivier BlazyJean-Christophe DeneuvillePhilippe GaboritSantosh GhoshShay GueronTim GüneysuCarlos Aguilar MelchorRafael MisoczkiEdoardo PersichettiJan Richter-BrockmannNicolas SendrierJean-Pierre TillichValentin VasseurGilles Zémor
• Organismes : Mathématiques & Sécurité de l'information University of Washington [Tacoma] Technology Innovation Institute [Abu Dhabi] Technology Innovation Institute [Abu Dhabi] École polytechnique Ecole Nationale de l'Aviation Civile Mathématiques & Sécurité de l'information Intel Corporation [Hillsboro] Department of Mathematics [Haïfa] Amazon Web Services [Seattle] Deutsches Forschungszentrum für Künstliche Intelligenz GmbH = German Research Center for Artificial Intelligence Ruhr University Bochum = Ruhr-Universität Bochum [Bochum] Quarkslab Google Inc Florida Atlantic University [Boca Raton] Ruhr University Bochum = Ruhr-Universität Bochum [Bochum] Cryptologie symétrique, cryptologie fondée sur les codes et information quantique Cryptologie symétrique, cryptologie fondée sur les codes et information quantique Université Paris Cité Cryptologie symétrique, cryptologie fondée sur les codes et information quantique THALES [France] Institut de Mathématiques de Bordeaux

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Fichiers liés : BIKE_Spec.2022.10.10.1.pdf

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Source

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• Type de publi. : Communication dans un congrès
• Date de publi. : 10/10/2022
• Auteurs : François HermetPhilippe Jean-PierreSébastien Bourdin
• Organismes : Centre d'Économie et de Management de l'Océan Indien Centre d'Économie et de Management de l'Océan Indien Métis Lab EM Normandie

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 10/10/2022
• Auteurs : Emeric MerourHatem HmidanCorentine MariePierre-Henri HelouHaiyang LuAntoine PotelJean-Baptiste HureAdrien ClavairolyYi Ping ShihSalman GoudarziSébastien DussaudRavassard P.Sassan HafiziSu Hao LoBassem A. HassanCarlos Parras
• Organismes : Institut du Cerveau = Paris Brain Institute
• Publié dans eLife le 23/10/2020

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Résumé : The differentiation of oligodendroglia from oligodendrocyte precursor cells (OPCs) to complex and extensive myelinating oligodendrocytes (OLs) is a multistep process that involves large-scale morphological changes with significant strain on the cytoskeleton. While key chromatin and transcriptional regulators of differentiation have been identified, their target genes responsible for the morphological changes occurring during OL myelination are still largely unknown. Here, we show that the regulator of focal adhesion, Tensin3 (Tns3), is a direct target gene of Olig2, Chd7, and Chd8, transcriptional regulators of OL differentiation. Tns3 is transiently upregulated and localized to cell processes of immature OLs, together with integrin-β1, a key mediator of survival at this transient stage. Constitutive Tns3 loss of function leads to reduced viability in mouse and humans, with surviving knockout mice still expressing Tns3 in oligodendroglia. Acute deletion of Tns3 in vivo, either in postnatal neural stem cells (NSCs) or in OPCs, leads to a twofold reduction in OL numbers. We find that the transient upregulation of Tns3 is required to protect differentiating OPCs and immature OLs from cell death by preventing the upregulation of p53, a key regulator of apoptosis. Altogether, our findings reveal a specific time window during which transcriptional upregulation of Tns3 in immature OLs is required for OL differentiation likely by mediating integrin-β1 survival signaling to the actin cytoskeleton as OL undergo the large morphological changes required for their terminal differentiation.

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Source

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• Type de publi. : Article dans une revue
• Date de publi. : 07/10/2022
• Auteurs : Houriiyah TegallyJames E. SanMatthew CottenMonika MoirBryan TegomohGerald MboowaDarren MartinCheryl BaxterArnold LambisiaAmadou DialloDaniel AmoakoMoussa DiagneAbay SisayAbdel-Rahman ZekriAbdou Salam GueyeAbdoul SangareAbdoul-Salam OuedraogoAbdourahmane SowAbdualmoniem MusaAbdul SesayAbe AbiasAdam ElzagheidAdamou LagareAdedotun-Sulaiman KemiAden Elmi AbarAdeniji JohnsonAdeola FowotadeAdeyemi OluwapelumiAdrienne AmuriAgnes JuruAhmed KandeilAhmed MostafaAhmed RebaiAhmed SayedAkano KazeemAladje BaldeAlan ChristoffelsAlexander TrotterAllan CampbellAlpha KeitaAmadou KoneAmal BouzidAmal SouissiAmbrose AgweyuAmel NaguibAna GutierrezAnatole NkeshimanaAndrew PageAnges YadouletonAnika VinzeAnise HappiAnissa ChouikhaArash IranzadehArisha MaharajArmel Batchi-BouyouArshad IsmailAugustina SylverkenAugustine GobaAyoade FemiAyotunde SijuwolaBaba MarycelinBabatunde SalakoBamidele OderindeBankole BolajokoDiarra BassirouBelinda HerringBenjamin TsofaBernard Lekana-DoukiBernard MvulaBerthe-Marie Njanpop-LafourcadeBlessing MaronderaBouh Abdi KhairehBourema KouribaBright AduBrigitte PoolBronwyn KleinhansCara E. BrookCarolyn WilliamsonCassien NduwimanaCatherine AnscombeCatherine PrattCathrine ScheepersChantal Akoua-KoffiCharles AgotiChastel MapanguyCheikh LoucoubarChika OnwuamahChikwe IhekweazuChristian MalakaChristophe PeyrefitteChukwa GraceChukwuma OmoruyiClotaire RafaïCollins Morang’aCyril EramehDaniel BugembeDaniel BridgesDaniel Mukadi-BamulekaDanny ParkDavid A. RasmussenDavid BakerD. James NokesDeogratius SsemwangaDerek TshiabuilaDominic AmuzuDominique GoedhalsDonald GrantDonwilliams OmuoyoDorcas MaruapulaDorcas WanjohiEbenezer Foster-NyarkoEddy LusamakiEdgar SimulunduEdidah Ong’eraEdith NgabanaEdward AbworoEdward OtienoEdwin ShumbaEdwine BarasaEl Bara AhmedElhadi AhmedEmmanuel LokiloEnatha MukantwariEromon PhilomenaEssia BelarbiEtienne Simon-LoriereEtilé AnohEusebio ManuelFabian LeendertzFahn TawehWasfi FaresFatma AbdelmoulaFaustinos TakawiraFawzi DerrarFehintola AjogbasileFlorette TreurnichtFolarin OnikepeFrancine NtoumiFrancisca MuyembeFrank RagomzingbaFred DratibiFred-Akintunwa IyanuGabriel MbunsuGaetan ThilliezGemma KayGeorge AkpedeGert van ZylGordon AwandareGrace KpeliGrit SchubertGugu MaphalalaHafaliana RanaivosonHannah OmunakweHarris OnyweraHaruka AbeHela KarrayHellen NansumbaHenda TrikiHerve Albéric Adje KadjoHesham ElgahzalyHlanai GumboHota MathieuHugo Kavunga-MemboIbtihel SmetiIdowu OlawoyeIfedayo AdetifaIkponmwosa OdiaIlhem Boutiba Ben BoubakerIluoreh Ahmed MuhammadIsaac SsewanyanaIsatta WurieIyaloo KonstantinusJacqueline Wemboo Afiwa HalatokoJames AyeiJanaki SonooJean-Claude MakangaraJean-Jacques TamfumJean-Michel HéraudJeffrey ShafferJennifer GiandhariJennifer MusyokiJerome NkurunzizaJessica UwanibeJinal BhimanJiro YasudaJoana de MoraisJocelyn KiconcoJohn SandiJohn HuddlestonJohn OdoomJohn MorobeJohn GyapongJohn KayiwaJohnson OkolieJoicymara XavierJones GyamfiJoseph WamalaJoseph BonneyJoseph NyandwiJosie EverattJoweria NakaseeguJoyce NgoiJoyce NamulondoOguzie JudithJulia AndekoJulius LutwamaJuma MoggaJustin O’gradyKatherine SiddleKathleen VictoirKayode AdeyemiKefentse TumediKevin CarvalhoKhadija SaidKoussay DellagiKunda MusondaKwabena DueduLamia Fki-BerrajahLavanya SinghLenora KeplerLeon BiscornetLeonardo de Oliveira MartinsLucious ChabukaLuicer OlubayoLul Deng OjokLul Lojok DengLynette Ochola-OyierLynn TyersMadisa MineMagalutcheemee RamuthMaha MastouriMahmoud El HefnawiMaimouna MbanneMaitshwarelo MatshekaMalebogo KebabonyeMamadou DiopMambu MomohMaria da Luz Lima MendonçaMarietjie VenterMarietou PayeMartin FayeMartin NyagaMathabo MarekaMatoke-Muhia DamarisMaureen MburuMaximillian MpinaMichael OwusuMichael WileyMirabeau TatfengMitoha Ondo’o AyekabaMohamed AbouelhodaMohamed Amine BeloufaMohamed SeadawyMohamed KhalifaMooko Marethabile MatoboMouhamed KaneMounerou SalouMphaphi MbulawaMulenga MwendaMushal AllamMy PhanNabil AbidNadine RujeniNadir AbuzaidNalia IsmaelNancy ElguindyNdeye Marieme TopNdongo DiaNédio MabundaNei-Yuan HsiaoNelson SilochiNgiambudulu FranciscoNgonda SaasaNicholas BbosaNickson MurungaNicksy GumedeNicole WolterNikita SitharamNnaemeka NdodoNnennaya AjayiNoël TordoNokuzola MbheleNorosoa RazanajatovoNosamiefan IguosadoloNwando MbaOjide KingsleyOkogbenin SylvanusOladiji FemiAdewunmi OlubusuyiOlumade TestimonyOlusola OgunsanyaOluwatosin FakayodeOnwe OgahOpe-Ewe OludayoOusmane FayePamela Smith-LawrencePascale OndoaPatrice CombePatricia NabisubiPatrick SemandaPaul OluniyiPaulo ArnaldoPeter QuashiePeter OkokherePhilip BejonPhilippe DussartPhillip BesterPlacide MbalaPontiano KaleebuPriscilla AbechiRabeh El-SheshenyRageema JosephRamy Karam AzizRené EssombaReuben Ayivor-DjanieRichard NjouomRichard PhillipsRichmond GormanRobert KingsleyRosa Maria D. E. S. A. 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BitrouBlaise Mboringong AkenjiBode ShobayoBoitumelo ZuzeBonifacio Manguire NlavoBouchra BelfquihBouchra BoujemlaBouna YatassayeBouzidi AymaneBrian AndikaBright YemiBronwyn KleinhansBruna GalvaoBubacar Delgado Pinto EmbalóBulelani ManeneButoyi PascalCamille CapelCampbell AnuCarine TchibozoCarla MadeiraCarlos CortesCarniel ElisabethCarol KifudeCarolle Yanique TayimethaCatherine ArnoldCatherine OkoiCecilia WaruhiuCelestin GodweCelestina ObiekeaCeline NkenfouL. ChabukaChakib NejjariH. ChambaroD. ChandaK. ChangulaCharifa Drissi TouzaniCharles KayukiCharles NyagupeCharles SsuunaCharoute HichamChaselynn WattersH. ChawechCheikh SokhnaChenaoui MohamedChiamaka NwubaC. ChilufyaChimaobi ChukwuChinyere AnyikaP.J. ChipimoS. ChitangaM. ChitenjeM. ChiwaulaChouati TahaChris MansellChristelle ButelChristian DevauxChristian DrostenChristian RanaivosonChristian UtpatelChristophe MalabatA. ChtourouG. ChukwuClaudia DaubenbergerClement KakaiClement MasakweClotaire Donatien RafaiCollins ChenwiCollins MisitaCollins MuliCorine GeurtsvankesselCorinne MaufraisCoulibaly MbegnanM. CrawfordCristina TatoCyrus YiabaN. d'AmoreDabiri DamilariDalia RamadanD. DamenaDaniel OusoDaniela PisanelliDanilo LicastroDavid HammerDavid NieuwenhuijseDavid Patrick KateeteDavid WilkinsonDavy Leger MouangalaDawit Hailu AlemayehuR.M. DawoodR. de SanctisDeborah MettleDemba KoitaDennis Kenyi LodiongoDennis LaryeaDennis WanderaDereje LetaDersi NoureddineDesire TakouDessalegn Abeje TeferaDhwani BatraDia NdongoA. DiabDiabou DiagneDiane MabikaDiané BamourouDianke SamatéB. DiarraDidier RaoultDieudonne MutanganaDineo Emang Tshiamo. Gape NyepetsiDiosdado Odjama Nseng AdaDjimabi SalahDonatella CedolaDoris HardingDorothy Yeboah-ManuDossou AngeDowbiss Meta DjomsiDragana DrinkovicC. DraperDumbuya Foday SahrEbenezer OdewaleEclou SedjroEdang-Minko ArmandEdgar KigoziEdith KoskeiEdith NkwembeEdmilson de Oliveira FilhoEdmira Maria da CostaEdward KirituEfrem LimEgon OzerB. EgyirEhab Abdelkader AbueleneinEitel Mpoudi NgoleEl Aliani AissamEl Ansari Fatima ZahraEl Hamouchi AdilEl Oualid AbdelmjidH. El-ShaqnqeryM. El-ZayatElamin AbualasElannaz HichamA. ElargoubiEleni KidaneElham RizgallaM.M. ElhosenyF.W. ElhosienyElisabeth CarnielElizabeth NyakarunguS.M. ElkhateebElmostafa BenaissaElmostafa El FahimeM. ElouanassM.H. ElsissyElvyre Mbongo-NkamaElwaleed LatifEmame EduEmanuele OrsiniEmilio SkarwanEmily StefanovEmmanuel NasingheEmmanuel NepoloEmmanuel OgunbayoEmmanuelle MungerEmmanuelle PermalEmna GaiesH. EnnibiEnnibi KhalidErasmus KoteyErasmus SmitEric LeloEric AduEric DelaporteEric KatagiryaEric KezakarayagwaEric MuthanjeErica Luis Maria MagalhãesErnest AsieduEsemu LivoEsperance UmumararunguEsther ChitechiEsther OmuseniEtoundi Mballa AlainEvelyn Bonney QuansahEvelyn BonneyM.H. EzzelarabFaatu CassamaFabien Roch NiamaFabio ArenaG. FaggioniE. FahsbenderFaith SigeiFaouzi AbdellahFarah JoualiH. FarawylaFarida HilaliFatima ChgouriFatima El FalakiFatima Zahra El AnsariFatma EbiedFatna BssaibisFattah Al OnifadeFaye OusmaneFayez Ahmed KhardineFayez KhardineA.V. FedorovFekadu AlemuFekkak JamalFengming SunFetouma DoudouA.E. FikryS. FilloFiorenza BracchittaFirmin KaboréL. Fki-BerrajahFlora DonatiFlorence FenollarFoday Sahr Samuel SorieO. FolarinoFrancine FolorunshoFrancisca KabatesiFrancisco Muyembe-MaweteFrançois MalagonFranklin KiemdéFranklyn Egbe Asiedu-BekoeFrédéric NkonghoFrederick LemoineR. FreitasT. Fuh-NebaI. GaaloulGabriel KabambaGadissa GutemaGaies EmnaGaladima GadzamaGalal MahmoudGarba OuangoleS. GargouriR. GarryGary McauliffeGathii KimitaGédéon Prince ManouanaGelanew TesfayeGeorge AwindaGeorge KyeiGeorge MichukiGeorgelin Nguema OndoGerhard van RooyenGert MaraisGetachew AbichuGetachew Tesfaye BeyeneGetachew TolleraGetnet HailuGhamaz HamzaGhazi KayaliGhizlane El AminGibson MhlangaGilbert KibetGildas HounkanrinF. GiordaniGizaw TekaGodfrey MaseteR. GoldstoneC. GomaaGomaa MokhtarGora LoB. GosnellA. GottbergGrace Angong BelournouGrace OniGrace VincentGregory WaniGuedi Ali BarrehGuillermo GarciaGuohong DengN. GusevaGuy Paterne Malonga MbemboGuy Stéphane PadzysS. GwayiHabiba Ben RomdhaneHabiba NaijaHaby DialloA. HadadM.M. HafezHafsia LadhariHagar ElshoraHailu DadiHajjaji MohammedHakima KabbajHala HafezA. HalafawyHalidou TintoHalimatou Diop NdiayeHamadi AssaneT.N. HamdaniM.S. HamdyHamidah NamagembeM. HammadA. HammamiHamza GharmazHana Sofia AnderssonHanae DakkaHanen El JebariHany SolimanHarmak HoudaR. HarveyHasnae BenkiraneHassan AguenaouHassan IhazmadR. HassanW. HassanHatem AhmedHeitzer SogodogoHelena Seth-SmithHelisoa RazafimanjatoHellen KokaHemlali MouhssineHenry MwebesaHermes PerezHerve Christian Paho TchoudjinHicham ElannazHicham OumzilHilda Opoku FrempongHinson FideliaHoda Ezz ElarabHong XieHouda BenrahmaHousna ArrouchiHoussem GuedouarHu LuoHubert BassèneHuiqing SiIan GoodfellowIbrahima GuindoIbrahima HalilouIdil Salah AbdillahiIdriss-Amine LahlouIdrissa DiawaraIfunanya EgohF.A. IgeA.A. IknaneIkram BnouyahiaIkram Omar OsmanIlhem Boutiba Ben BoubakerIman Abdillahi HassanIman FodaImane SmyejImen KacemImen MdiniImen MkadaInacio MandomandoIñaki ComasInes MdiniL. InglêsInnocent MudauIreoluwa Yinka JoelIrina ChestakovaIrving CancinoIsaac PhiriIsmael Pierrick Mikelet BoussoukouA. IsmailIsrael Osei-WusuIssaka MamanIvan BarilarIvy AsanteIzuwayo GerardJaafar HeikelJacob SouopguiJacques MarxD. JalalJalal NourlilJalil El AtarJalila Ben KhelilJalila RahouiJamal FekkakJames MutisyaJames UssherJan Felix ExlerJane MacauleyJanet MajanjaN. JannooJarra MannehJasmin ScharnbergJasmin SchlotterbeckJasper ChimedzaJawad BouzidJean NiyibigiraJean Claude DjontuJean MaritzJean-Claude Makangara CigoloJean-Louis MonemouJeanne D’arc UmuringaJeremy DelerceJerome NdaruhutseJerome NkurunzizaJesse Addo AsamoahJill SherwoodJing WangJoan Marti-CarerrasJoe MutungiJoe MutungiJoel Fleury Djoba SiawayaJoel KoivoguiJoep de LigtJohn NjugunaJohn RumunuJohn TemboJohn WaitumbiJohnson AdenijiJonathan RigbyJorn HellemansJoseph FokamJoseph DerisiJoseph MakhemaJoseph MugishaJoseph Ojonugwa ShaibuJoseph Oliver-CommeyJosephine BwogiJosh FreemanJosiah Ayoola IsongJosphat NyatayaJoy AyoolaJoyce Appiah-KubiJudd HultquistJude GedeonJudith SokeiJulia HowardJulia SchneiderJulian CampbellJuliet ElvyA.B. JumaaJustin LeeJustin LesslerJustin O'GradyKaba KouroumaKais GhediraK. KalantarKamela MahlakwaneS. KamounKangwa MulongaP.C. KapataF. KapayaM. Kapin'AH. Karray HakimW. KasambaraKasmi YassineKassahun TesfayeKathleen SubramoneyA.D. KatyshevN. KayeyiKayla BarnesKayla DelaneyE.V. KazorinaKedumetse SeruS. KeitaKeith DurkinKeith JeromeKeke RenéKena SwansonKenneth MaekaKeren Okyerebea AttikuKevin SandersKevine Zang EllaKeyru TukiKhabab ElhagKhadim GueyeKhaled AmerKhalid Ennibi MostafaN. KharatZ. KhumaloKilian StoeckerL. KimKimberly Bishop-LillyJ. KimothoKitane Driss LahlouKofi BonneyKokou TegueniKolawole Wasiu WahabE.V. KolomoetsKomal JainKominist AsmamawKomlan KossiKondwani JamboKouadio YaoKouriba DürrKra OuffouéY.M. KrasnovKrishna Kumar KandaswamyKristian AndersenA.A. KritskyKumbelembe DavidKutlo MachekeV.V. KutyrevS. KwendaKwitaka MaluziKwok LeeKyle LongKyra GrantzLacy SimonsLaetitia SerranoLaila ElsawyLaila SbabouLallepak LamboniLarinda HollandLasata ShresthaLassana SangaréLatifa AngaLauren JellyLaurien HoornaertLe Thi Kieu LinhLegodile KooepileLeigh-Anne Mc IntyreLéon MutesaLeona OkoliLéopold OuedraogoKuate-Lere LesegoD. LetaA. LetaiefG. LiboroLilian KanjauL. LinLinda BoatemaaLinda HouhamdiLipkin IanF. ListaM.M. LiweweLloyd MulengaLogan VoegtlyLoide ShipinganaLoris MicelliLorreta KwasahLoubna AllamLouise LefrançoisLoukman SalmaLucas Amenga-EtegoLudivine BrecharLudovic MewonoLuis EstrellaLusia MhuuluLwanga NewtonM. UlrichM.T. MogotsiMaaroufi AbderrahmaneW. MadW.Y. MadiMadlen StangeS. MagdeldinMaher KharratB. MahlanguMahmoud ShehataN. MahrousA. MaidaMakhtar CamaraT. MakoriK. MalamaMalena Bestehorn-WillmannI. MaloloMamadou Beye Cheikh Ibrahima LoMamadou Bhoye KeitaMamadou Saliou BahMamadou Saliou SowMamoudou Harouna DjingareyMamoudou MaigaManal Hamdy ElsaidManal Hamdy ZahranMandiou DiakiteManel Ben SassiMangombi PambouN. ManickchundManoli Torres PuenteS. ManrajT. MansourMaowia MukhtarMarcel TongoMarchoudi NabilaMargaret MillsMaria ArtesiMaria Pia PatrizioMaria Rita GismondoMaria Rosaria LipsiMariam Kehinde SulaimanMariama KujabiMarie AmougouMarie Claire OkomoMarie Madeleine Chabert-ConsenMarie-Astrid VernetMarie-Pierre HayetteMariem GdouraMarijke ReyndersMarion BarbetMarion KoopmansMarjan BoterMark SiednerMarkos AbebeMarkus AntwerpenMarouane MelloulMartin Maidadi FoudiMartine PeetersMarvin HsiaoMary DealmeidaMary LalemiMary-Ann DaviesK. MasahiroMasse SambouM. MathaboMathew ParkerMathias WalterH. MathurMatt BlakistonMatt StoreyMatthew BatesMatthew RogersMatthias PauthnerMaud VanpeeneMaurizio MargaglioneMax BloomfieldMay AbdelfattahMay Sherif SolimanMbengué FallK. MdlaloseMeei-Li HuangS. MehtaMélanie AlbertMelchior AïssiMéline BizardMerabet MouadMeriem LaamartiMessanh DouffanS. MhallaMichael AddidleMichael MarksMichael NagelMichael DeschenesMicheala DavidsMichelle BalmMichelle LinMichelle TanA. MihreteMikhail Olayinka BuhariMilanca Agostinho CáMildred Adusei-PokuMilkah MwangiMina KamelJ. MirandaMireille Prince-DavidMiriam EshunMisaki WayengeraMitali MishraMjid EloualidMly Abdelaziz ElalaouiA. MnguniF. MnyameniMogomotsi MatshabaT. MohaleMohamed Abdel-Salam ElgoharyMohamed Ahmed AliMohamed Ben MoussaMohamed ChenaouiMohamed El SayesMohamed ElhadidiMohamed Gomaa SeadawyMohamed Hassan AbdoelraheemMohamed HassanyMohamed Houmed AboubakerK.S. MohamedMohamed KamalMohamed RhajaouiMohamed SeadawyMohamed ShamelMohamed ShemisK.S. MohammedMohammed Walid Chemao ElfihriMohcine Bennani MechitaMokhtar GomaaMolalegne BitewM. MomohMona O.A. AlkarimMonemo PacomeMonilade AkinolaA. MonteG. MonuirM. MonzeM. MookoA.N. MoralesMoreira-Soto AndresMoriba PovoguiMosepele MosepeleMoses ChilufyaMoses JolobaMoses LuutuMostafa ElouennassMostfa ElhoseinyMostfa ElnakibMostfa YakoutMouhcine GardoulMouhssine HemlaliA. Mouity MatoumbaMouna Ben SassiMouna SaferMouneem EssabbarMoustapha MbowMoustapha Nzamba MaloumMoustapha SakhoMoyinoluwa OdugbemiP. MtshaliB. MubembaMuchaneta MugabeM. MufindaMuhammad FaisalMuinah Adenike FoworaMukantwari EnathaW. MuleyaMuntaser Eltayeb IbrahimF. MupetaMurebwayire ClarisseMushal AliMushal AllamMustapha MouallifS.N. MuuoW. MwangombaMyriam SeffarT. MzumaraN. N'DilimabakaNabila SoaraA. NabliNadia El MrimarNadia RodriguesNadia SitoeNafisatou LeyeA. NaguibK. NalubambaNancy El GuindyNandi SiegfriedNardjes HihiNarjis AmarE.A. NaryshkinaNathalia EndjalaNathalia Garus-OasNathan KapataNdack NdiayeNdahafa FransN.T. NdamNdéye Coumba Touré KaneNdiaye NdackNdine FainguemNdodo NnaemekaNdumbu PentikainenL. NdwigaNedio MabundaN. NeffA.A. NegashNejla StambouliZ. NetoA.M. Ngonga DikongoW. NgosaNgozi Mirabel OtuonyeF. Niatou-SingaNicaise NdamNicholas FeaseyNicholas MwikwabeJ. NicodNicole VidalNikki FreedNischay MishraNissaf Ben AlayaNitin SavaliyaNoah BakerNoé Patrick MbondoukweNokukhanya MdlaloseNonso NdukaNoura Abo ShamaNourlil JalalNsubuga GideonN. NtuliNuro AbilioNyam Itse YusufOby WayoroM. OchwotoOfonime EbongL. Ofori-BoaduOkomo Assoumou Marie ClaireOla ElrobyOlabisi OlabisiOlajumoke OjoL. OlfertOlin SilanderOlufemi ObafemiOlufemi Samuel AmooOlukunke OluwasemowoOlusola Anuoluwapo AkanbiOluwakemi Laguda-AkingbaOluwatimilehin AdewumiOmar AskanderOmar ElahmerS. OmarS. OmilabuOmnia KutkatOmoare AdesuyiOmondi Francis CareyOnalethata LesetediE. OngeraOntlametse BarengC.K. OnwuamahO. Ope-EweOsama MansourOscar KanjerwaF. OtengOtmane TouzaniOumaima Ait Si MohammedOumy DiopOuna OuadghiriOusseynou GueyeC. Owusu-NyantakyiA. OyefoluOyeronke AyansolaP NthigaS. PalombaL. PanjaPapa Alassane DiawD. ParkPasacaline MangaH. PatelPatience MotshosiM. PatooPatrick AmothPatrick DescheemaekerPatrick MavinguiPatrick TuyisengeM. PattooPaul DobiPaul LiberatorPaulin EssonePaulina Joãozinho da Costa Jarra MannehPauline Yacine SenePaulo PaixãoPavitra RoychoudhuryPeace UchePei ZhouPenda Malhado DialloA. PereiraPetas AkogbetoPeter BauerPeter SkidmorePetra RaimondPhasha-Muchemenye MmatshephoPhilip AshtonC. PhilipPhilip El-DuahPhilip SogloPhilip Wonder PhiriPhilipp WagnerPhilippe ColsonPhilippe DussartPhilippe Lavrard MeyerPhillip AshtonPhionah TushabePierre-Edouard FournierPiet MaesPopova YuPortia ManangaziraPraise AdewumiQi YangQuaneeta MohktarE.B. QuansahP. QuashieRabia QuedraogoRachel MaqsoodRachid GithiiRachid AbiRachid BenhidaRachid El JaoudiRahaman MentagRahma AhmedRaiva AlgherianiRajiha SimbiRamalia Chabi AbubekerRamon NariRamy Lorenzo-RedondoA. RaoufRaoul SaizonouRaphael LumembeRavena MubichiRegina CerReham DawoodReham KassabRehema LiyaiA. RehnRei José PereiraReina SikkemaRfaki AbderrazakRiad Mounir ArmaniousRiadh DaghfousRiadh GouiderRichard AdegbolaRichard Lino Loro LakoRichard MolenkampRichard WebbyRichmond YeboahS. RickRida TagajdidRine Zeh NforRivalyn Nakoune YandokoRobert NewtonRobert RutayisireRodney DanielsRodrigue BikanguiRodrigue KohounRodrigue KamgaRodrigue Mintsa NguemaRoger ShapiroJ. RogersRogers KamulegeyaRokaia LaamrtiRoméo Aimé Laclong LontchiRonald KiizaRonald GaliwangoRosella de NittisW.H. RoshdyRotimi Myrabelle Avome HouechenouRoua Ben OthmanRui InndiM.A. SaadSaaïd AmzaziSabin NsanzimanaSada DialloY.A. SadjiSafae El MazouriSafae ElkochriSafae GhoulameSafiatou KaridioulaSafietou SankheSahr GevaoP.F. SahrJ.O. SaibuSaïdou OuedraogoS. SaiidSainabou Laye NdureSakoba KeitaD. SalahSalah Eldin HusseinH. SalahA.A. SalehM. SalehSalifou SourakatouSally RobertsSalma AbidSalma SayedM. SalouO.B. SaluSam LissauerSam O'Neilla Oye BingonoSamba NdiourSameira FageerSamia Abdou GirgisM. SamirO. SamirSamira BenkeroumSamira IbrahimSamira FageerSamira Zoa AssoumouSamirah SaiidSamoel Ashimosi KhamadiSamson Konongoi LimbasoSamuel ArmooSamuel KirimundaSamuel SorieSamwel Lifumo SymekherSamwel OwakaSana FerjaniSanaa Alaoui-AmineSander Anna-LenaSankhe SafietouSantiago Jiménez-SerranoSantigie KamaraSara ChammamSara MahmoudSarah JefferiesSarah RubinSarah StanleySaraswathi SatheesSaro AbdellaSarra ChammanSavannah MwesigwaH. SawaM.G. SeadawySean EllisSébastien BontemsSefetogi RamaologaSekesai ZinyoweraSelassie KumordjieSen Claudine Henriette NgomtchoSena AwunyoSerge Alain Sadeuh-MbaSerigne Saliou NianeSeth OkeyoSettimia AltamuraSeyram Bless AgbenyoShah Mohamed BakhashShahin LockmanShahinaz.A. BedriShaimaa SolimanL. ShalabyShannon WilsonSharmini MuttaiyahSharon AbimbolaSharon HsuS.A. ShcherbakovaShebbar OsianyShereen ShawkySherine HelmyA.P. ShevtsovaShimaa MoustafaShirlee WohlShirley JohaneSidonie A.M. KagnissodeSilvanos Mukunzi OpandaSim MayaphiSimão Tchuda BiótéSimeone Dal MonegoSimon Peter RuhwezaSimone EcksteinSindayiheba ReubenN. SinyangeSivaramakrishna RachakondaSoa Fy AndriamSofia ViegasSokhna SogodogoSola NdongoSolomon AjibayeSombo LangatSomda Soro Georgina FwoloshiSonal CharleneSondes HensonSonia HaddadE.A. SosedovaSouad KarttiSouissi AmiraSouleymane MboupSoundélé MaïtéSounkalo DaoSourakatou SalifouSrinivas Reddy PallerlaStefan NiemannSteffen BorrmannStephen AsiimweStephen EgganStephen OcholaStephen WanokSteven ReynoldsSubomi OlorunnimbeSudhir BungaC. SujeewonSunday BabatundeSusan EngelbrechtSusan MorpethSusan TaylorSusann HandrickSwaibu GatareSylvie MelinguiS.L. SymekerSyntyche DevatchagniA.G. TahaTaha ChouatiTaha MaatougTahar BajjouA. TakadaK.A. TaloaTamrayehu SeyoumM. TanTania StanderTanja NiemannTarek AannizTarek Refaat Elnagdy Raafat ZaherTatenda TakawiraC. TatoD.A. TeferaTei-Maya FredTesfaye GelanewTesfaye RufaelThanh Le VietThela TefeloThérèse KagonéThibaut Armel Chérif GnimadiK. ThiongoThomas BrieseVan ThomasThongbotho MphoyakgosiThushan de SilvaTim RoloffTimothy BlackmoreTiziana RolloTom LutaloTomade A.M. IbrahimT. TombolomakoTomiwa AdepetunC. Tomkins-TinchTony Wawina-BokalangaTope SobajoTouil NadiaTouria EssayaghToy NwakoH. TrikiR. TsiryTsiry RandriambolamanantsoaTumisang MadisaM. TurkiC.A. UgwuUyi EmokpaeValeria Delli CarriValeria MicheliG. van RooyenM. VanaerschotVanessa MagnussenVanessa MohrVani SathyendranVeronica PlayleR. VianaU. VickosVictor Max CormanVictor MukonkaVictor OfulaVida AhyongVincent AppiahVincent BoursViolette M'CormackVirginia HopeVivi Hue-Trang LieuVololoniaina RaharinosyWadegu MeshackN. WadondaJ. WadulaWael AliWaidi SuleWallace BulimoWarren Cyrus YiabaC.N. WaruhiuR. WebbyA.G. WeldemariamWendy Karen JoR. WoelfelS. WolhI. WurieXavier CrespinXiaoyun RenXiuhua WangYa.M. KrasnovYacine Amet DiaYacine Dia Seni NdiayeYacob Mohamed YusufYacouba SawadogoYahya YadouletonYakob Gebregziabher MaidaneYao TsegayYasser LayiboYassine El HadyYassmin SekhsokhYawo MoatasimC. YeboahYoubi MohammedYousif Rabih MakkiYoussef AkhoudYuri UshijimaYusuf JimohYvette BadouJ. Matoke D. ZablonJ.O. ZablonZaineb HamzaouiZakia RegraguiZara WuduriZein SoumaZeinab Ali WaberiZeinab ImamZekiba TarnagdaZemmouri FaouziaJ. ZhangZhenghui LiZimmerman MaigaZohour KasmyMinko ZongAli ZorganiZouheir YassineZoukaneirii IssaP. ZuluZuzheng Xiang
• Organismes : Institut Pasteur de Dakar Institut Pasteur de Dakar Centre de Recherche Médicale et Sanitaire [Niamey, Niger] Université Gamal Abdel Nasser de Conakry Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Institut Pasteur de Tunis Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar) University of Chicago Institut Pasteur de Madagascar Institut Pasteur de Dakar Institut Pasteur de Bangui Institut Pasteur de Dakar Institut National de Recherche Biomédicale [Kinshasa] University of Kinshasa Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes Génomique évolutive des virus à ARN - Evolutionary genomics of RNA viruses Institut Pasteur de Tunis Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar) Institut Pasteur d'Algérie Institut Pasteur de Madagascar Institut Pasteur de Tunis Tunis El Manar University [University of Tunis El Manar] [Tunisia] = Université de Tunis El Manar [Tunisie] = جامعة تونس المنار (ar) Institut Pasteur de Côte d'Ivoire Institut Pasteur de Dakar Institut Pasteur de Madagascar Direction Internationale de l'Institut Pasteur Direction Internationale de l'Institut Pasteur Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur d'Algérie Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur de Dakar Institut Pasteur de Guinée Institut Pasteur de Madagascar Institut Pasteur de Dakar Centre hospitalier de Mayotte [Mamoudzou] Institut Pasteur de Madagascar Centre Pasteur du Cameroun Institut Pasteur de Dakar Institut Pasteur de Madagascar Institut Pasteur de Guinée Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses Institut Pasteur de Dakar Institut Pasteur de Madagascar
• Publié dans Science le 22/10/2020

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Résumé : INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century.

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Fichiers liés : science.abq5358.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 07/10/2022
• Auteurs : Adrien Bertrand-ChapelCassandre CaligarisTanguy FenouilClara SavarySophie AiresSylvie MartelPaul HuchedéChristelle ChassotVéronique ChauvetVictoire Cardot-RuffinoAnne-Pierre MorelFabien SubtilKayvan MohkamJean-Yves MabrutLaurie TononAlain ViariPhilippe Alexandre CassierValérie HervieuMarie CastetsAlain MauvielStéphanie SentisLaurent Bartholin
• Organismes : Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Hospices Civils de Lyon Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Hospices Civils de Lyon Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 Service de Biostatistiques [Lyon] Hospices Civils de Lyon Hospices Civils de Lyon Synergie Lyon Cancer-Platform of Bioinformatics-Gilles Thomas Hospices Civils de Lyon Equipe de recherche européenne en algorithmique et biologie formelle et expérimentale Synergie Lyon Cancer-Platform of Bioinformatics-Gilles Thomas Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Hospices Civils de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Institut Curie [Paris] Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon Centre Léon Bérard [Lyon] Centre de Recherche en Cancérologie de Lyon
• Publié dans Communications Biology le 26/10/2020

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Résumé : TGF-β signaling is involved in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis, representing one of the four major pathways genetically altered in 100% of PDAC cases. TGF-β exerts complex and pleiotropic effects in cancers, notably via the activation of SMAD pathways, predominantly SMAD2/3/4. Though SMAD2 and 3 are rarely mutated in cancers, SMAD4 is lost in about 50% of PDAC, and the role of SMAD2/3 in a SMAD4-null context remains understudied. We herein provide evidence of a SMAD2/3 oncogenic effect in response to TGF-β1 in SMAD4-null human PDAC cancer cells. We report that inactivation of SMAD2/3 in SMAD4-negative PDAC cells compromises TGF-β-driven collective migration mediated by FAK and Rho/Rac signaling. Moreover, RNA-sequencing analyses highlight a TGF-β gene signature related to aggressiveness mediated by SMAD2/3 in the absence of SMAD4. Using a PDAC patient cohort, we reveal that SMAD4-negative tumors with high levels of phospho-SMAD2 are more aggressive and have a poorer prognosis. Thus, loss of SMAD4 tumor suppressive activity in PDAC leads to an oncogenic gain-of-function of SMAD2/3, and to the onset of associated deleterious effects.

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Fichiers liés : s42003-022-03994-6.pdf

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• Type de publi. : Article dans une revue
• Date de publi. : 05/10/2022
• Auteurs : Michaela I HegglinAna BastosHeinrich BovensmannMichael BuchwitzDominic FawcettDarren GhentGemma KulkShubha SathyendranathTheodore G ShepherdShaun QueganRegine RöthlisbergerStephen BriggsCarlo BuontempoAnny CazenaveEmilio ChuviecoPhilippe CiaisDavid CrispRichard EngelenSuvarna FadnavisMartin HeroldMartin HorwathOskar JonssonGabriel KpakaChristopher J MerchantChristian MielkeThomas NaglerFrank PaulThomas PoppTristan QuaifeNick A RaynerColas RobertMarc SchröderStephen SitchSara VenturiniRobin van der SchalieMendy van der VlietJean-Pierre WigneronR. Iestyn Woolway
• Organismes : Department of Meteorology [Reading] Max Planck Institute for Biogeochemistry Institute of Environmental Physics [Bremen] Institute of Environmental Physics [Bremen] College of Life and Environmental Sciences [Exeter] NERC National Centre for Earth Observation NERC National Centre for Earth Observation NERC National Centre for Earth Observation Jülich Supercomputing Centre School of Mathematics and Statistics [Sheffield] Federal Office for the Environment Department of Meteorology [Reading] European Centre for Medium-Range Weather Forecasts Laboratoire d'études en Géophysique et océanographie spatiales Universidad de Alcalá [Alcalá de Henares, España] = University of Alcalá [Alcalá de Henares, Spain] = Université d'Alcalá [Alcalá de Henares, Espagne] Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] Jet Propulsion Laboratory European Centre for Medium-Range Weather Forecasts Indian Institute of Tropical Meteorology German Research Centre for Geosciences - Helmholtz-Centre Potsdam Technische Universität Dresden = Dresden University of Technology Swedish Environmental Protection Agency Sierra Leone Meteorological Agency, Freetown Department of Meteorology [Reading] German Federal Environmental Agency / Umweltbundesamt Environmental Earth Observation IT GmbH Department of Geography [Zürich] Deutsches Zentrum für Luft- und Raumfahrt [Köln] Department of Meteorology [Reading] Met Office Hadley Centre Centre interprofessionnel technique d'études de la pollution atmosphérique German Weather Service College of Life and Environmental Sciences [Exeter] Group on Earth Observations Planet, Harlem Interactions Sol Plante Atmosphère School of Ocean Sciences, College of Environmental Sciences and Engineering, Bangor University,
• Publié dans Frontiers in Environmental Science le 01/11/2020

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Résumé : Space-based Earth observation (EO), in the form of long-term climate data records, has been crucial in the monitoring and quantification of slow changes in the climate system-from accumulating greenhouse gases (GHGs) in the atmosphere, increasing surface temperatures, and melting sea-ice, glaciers and ice sheets, to rising sea-level. In addition to documenting a changing climate, EO is needed for effective policy making, implementation and monitoring, and ultimately to measure progress and achievements towards the overarching goals of the United Nations Framework Convention on Climate Change (UNFCCC) Paris Agreement to combat climate change. The best approach for translating EO into actionable information for policymakers and other stakeholders is, however, far from clear. For example, climate change is now self-evident through increasingly intense and frequent extreme events-heatwaves, droughts, wildfires, and flooding-costing human lives and significant economic damage, even though single events do not constitute "climate". EO can capture and visualize the impacts of such events in single images, and thus help quantify and ultimately manage them within the framework of the UNFCCC Paris Agreement, both at the national level (via the Enhanced Transparency Framework) and global level (via the Global Stocktake). We present a transdisciplinary perspective, across policy and science, and also theory and practice, that sheds light on the potential of EO to inform mitigation, including sinks and reservoirs of greenhouse gases, and adaptation, including loss and damage. Yet to be successful with this new mandate, EO science must undergo a radical overhaul: it must become more user-oriented, collaborative, and transdisciplinary; span the range from fiducial to contextual data; and embrace new technologies for data analysis (e.g., artificial intelligence). Only this will allow the creation of the knowledge base and actionable climate information needed to guide the UNFCCC Paris Agreement to a just and equitable success.

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Fichiers liés : fenvs-10-941490.pdf

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• Type de publi. :
• Date de publi. : 05/10/2022
• Auteurs : Pierre-Michel MengerJean-Philippe Denis
• Organismes : Centre de sociologie du travail et des arts Collège de France Université Paris-Saclay Réseaux Innovation Territoires et Mondialisation

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Résumé : Xerfi Canal a reçu Pierre-Michel Menger, Sociologue et professeur au Collège de France, pour parler du travail créateur et de la subordination hiérarchique. Une interview menée par Jean-Philippe Denis.

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Fichiers liés : Travail_createur_et_subordination_mission_impossible_Pierre_Michel_Menger_.mp4

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• Type de publi. :
• Date de publi. : 04/10/2022
• Auteurs : Nathalie KorboulewskyPhilippe BalandierYves BoscardinOlivier ChaintreuilCamille CouteauAdélie ChevalierYann DumasMarion GosselinJean-Pierre HamardAviva KaraAnders MårellThomas PerotSandrine Perret
• Organismes : Ecosystèmes forestiers Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers Ecosystèmes forestiers

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Résumé : Présentation du dispositif

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• Type de publi. : Article dans une revue
• Date de publi. : 03/10/2022
• Auteurs : David SulmanMichel ZeitouniJohanne SilvainMathieu KerneïsPaul GuedeneyOlivier BarthélémyDelphine BrugierPierre SabouretBenoît LattucaEmilie MertensJulianne PossonNiki ProcopiTomy SalloumJean-Philippe ColletGilles Montalescot
• Organismes : Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases Groupe Action CHU Pitié-Salpêtrière [AP-HP] CHU Pitié-Salpêtrière [AP-HP] Groupe Action Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases
• Publié dans European Heart Journal - Cardiovascular Pharmacotherapy le 31/10/2019

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Résumé : Aims: The European Society of Cardiology (ESC) has released three consecutive guidelines within 5 years addressing cardiovascular prevention, risk scores, and cholesterol treatment. This study aims to evaluate whether the 2021 ESC guidelines improved the eligibility of individuals for primary prevention statin therapy before their first ST-segment elevation myocardial infarction (STEMI), and for intensive lipid-lowering treatments in secondary prevention. Methods and results: The cardiovascular risk category of 2757 consecutive individuals admitted for a first STEMI was evaluated to assess whether they would have been eligible for primary prevention statins according to 2021 vs. 2019 and 2016 ESC guidelines. Eligibility for intensive lipid-lowering therapy in secondary prevention was assessed according to the real-life follow-up low-density lipoprotein cholesterol (LDL-C) and the expected follow-up LDL-C. More individuals would have been eligible for primary prevention statins according to 2021 and 2019 vs. 2016 guidelines (61.8% vs. 38.7% vs. 23.6%, P < 0.01), a finding observed in both men (62.3% vs. 35.0% vs. 24.9%, P < 0.01) and women (60.2% vs. 50.7% vs. 19.3%, P = 0.18). Only 27% of individuals reached the LDL-C objective of 55 mg/L in secondary prevention: using the ESC stepwise approach, 61.7% were eligible for higher doses of statins, 26.2% for ezetimibe, and 12.1% for a proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor (PCSK9i). Based on expected LDL-C reductions, eligibility for a PCSK9i in secondary prevention was greater with 2021 vs. 2016 guidelines (44.5% vs. 22.5%, P < 0.01). Conclusion: The 2021 ESC guidelines improved the detection and treatment of individuals at risk for a first myocardial infarction. In secondary prevention, 70% of patients kept LDL-C levels above 55 mg/dL: increasing the statin dose and adding ezetimibe were the most frequently recommended therapeutic actions.

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